GALR2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Galanin is an important neuromodulator present in the brain, gastrointestinal system, and hypothalamopituitary axis. It is a 30-amino acid non-C-terminally amidated peptide that potently stimulates growth hormone secretion, inhibits cardiac vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility. The actions of galanin are mediated through interaction with specific membrane receptors that are members of the 7-transmembrane family of G protein-coupled receptors. GALR2 interacts with the N-terminal residues of the galanin peptide. The primary signaling mechanism for GALR2 is through the phospholipase C/protein kinase C pathway (via Gq), in contrast to GALR1, which communicates its intracellular signal by inhibition of adenylyl cyclase through Gi. However, it has been demonstrated that GALR2 couples efficiently to both the Gq and Gi proteins to simultaneously activate 2 independent signal transduction pathways. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit biogenesis (GO:0042274)6.44733588
2pyrimidine deoxyribonucleotide catabolic process (GO:0009223)6.13315475
3viral transcription (GO:0019083)5.57312035
4Golgi transport vesicle coating (GO:0048200)5.34770998
5COPI coating of Golgi vesicle (GO:0048205)5.34770998
6translational termination (GO:0006415)5.29964541
7pyrimidine nucleotide catabolic process (GO:0006244)5.29524866
8amyloid precursor protein catabolic process (GO:0042987)5.07621063
9folic acid-containing compound biosynthetic process (GO:0009396)5.06054388
10deoxyribonucleoside monophosphate metabolic process (GO:0009162)5.02901135
11L-alpha-amino acid transmembrane transport (GO:1902475)4.88759750
12L-serine metabolic process (GO:0006563)4.86124537
13translational elongation (GO:0006414)4.68807265
14ribonucleoprotein complex biogenesis (GO:0022613)4.68009186
15tooth mineralization (GO:0034505)4.65657731
16pyrimidine deoxyribonucleotide metabolic process (GO:0009219)4.51011734
17ribosomal small subunit assembly (GO:0000028)4.49636812
18peptidyl-histidine modification (GO:0018202)4.49354917
19ribosome biogenesis (GO:0042254)4.46883035
20SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.46610734
21cotranslational protein targeting to membrane (GO:0006613)4.36104282
22negative regulation of cell size (GO:0045792)4.35170015
23GDP-mannose metabolic process (GO:0019673)4.34964946
24protein targeting to ER (GO:0045047)4.31405803
25deoxyribonucleotide catabolic process (GO:0009264)4.25605049
26regulation of posttranscriptional gene silencing (GO:0060147)4.24389044
27regulation of gene silencing by miRNA (GO:0060964)4.24389044
28regulation of gene silencing by RNA (GO:0060966)4.24389044
29regulation of translational termination (GO:0006449)4.22792674
30viral life cycle (GO:0019058)4.12833634
31regulation of translational fidelity (GO:0006450)4.12787940
32establishment of protein localization to endoplasmic reticulum (GO:0072599)4.12306393
33activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.10365377
34deoxyribose phosphate catabolic process (GO:0046386)4.08589252
35regulation of mammary gland epithelial cell proliferation (GO:0033599)4.02977485
36muscle organ morphogenesis (GO:0048644)4.02701828
37protein localization to endoplasmic reticulum (GO:0070972)4.02634287
38positive regulation of nuclease activity (GO:0032075)4.02550012
39IMP biosynthetic process (GO:0006188)3.98421185
40ribosomal large subunit biogenesis (GO:0042273)3.97932631
41cellular protein complex disassembly (GO:0043624)3.95498215
42nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.95434311
43DNA strand renaturation (GO:0000733)3.93241328
44UTP biosynthetic process (GO:0006228)3.85023790
45DNA replication initiation (GO:0006270)3.81988135
46nodal signaling pathway (GO:0038092)3.78309062
47translational initiation (GO:0006413)3.78301002
48base-excision repair, AP site formation (GO:0006285)3.74484839
49purine nucleobase biosynthetic process (GO:0009113)3.74291288
50regulation of tight junction assembly (GO:2000810)3.73881767
51heterochromatin organization (GO:0070828)3.73104513
52cellular component biogenesis (GO:0044085)3.69652290
53DNA strand elongation involved in DNA replication (GO:0006271)3.67086535
54DNA strand elongation (GO:0022616)3.66435326
55serine family amino acid biosynthetic process (GO:0009070)3.66102001
56pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.65575637
57cell migration involved in gastrulation (GO:0042074)3.65093042
58regulation of nuclease activity (GO:0032069)3.64806929
59regulation of NFAT protein import into nucleus (GO:0051532)3.64711911
60pre-miRNA processing (GO:0031054)3.63854935
61GTP biosynthetic process (GO:0006183)3.62900565
62regulation of protein heterodimerization activity (GO:0043497)3.61491544
63maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.59074791
64endoplasmic reticulum unfolded protein response (GO:0030968)3.58338794
65termination of RNA polymerase III transcription (GO:0006386)3.57916412
66transcription elongation from RNA polymerase III promoter (GO:0006385)3.57916412
67coenzyme A biosynthetic process (GO:0015937)3.57707163
68peptidyl-arginine omega-N-methylation (GO:0035247)3.56982882
69muscle cell fate commitment (GO:0042693)3.52410812
70pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.51709451
71nuclear envelope disassembly (GO:0051081)3.51014452
72membrane disassembly (GO:0030397)3.51014452
73guanosine-containing compound biosynthetic process (GO:1901070)3.49797198
74regulation of mitochondrial translation (GO:0070129)3.49071000
75pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.48051550
76regulation of protein homodimerization activity (GO:0043496)3.47575318
77positive regulation of SMAD protein import into nucleus (GO:0060391)3.46464718
78cellular response to unfolded protein (GO:0034620)3.45865760
79mitotic nuclear envelope disassembly (GO:0007077)3.45361379
80protein complex disassembly (GO:0043241)3.43766842
81nucleobase-containing small molecule interconversion (GO:0015949)3.41985132
82peptidyl-arginine methylation (GO:0018216)3.41658951
83peptidyl-arginine N-methylation (GO:0035246)3.41658951
84telomere maintenance via semi-conservative replication (GO:0032201)3.41122438
85amyloid precursor protein metabolic process (GO:0042982)3.40878062
86UTP metabolic process (GO:0046051)3.40474746
87ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043163.38031703
88translation (GO:0006412)3.37909211
89positive regulation of T cell apoptotic process (GO:0070234)3.37043550
90formation of translation preinitiation complex (GO:0001731)3.36597491
91positive regulation of protein homodimerization activity (GO:0090073)3.34851972
92CTP biosynthetic process (GO:0006241)3.34133390
93CTP metabolic process (GO:0046036)3.34133390
94maternal placenta development (GO:0001893)3.31211147
95rRNA transcription (GO:0009303)3.30903123
96regulation of chromatin binding (GO:0035561)3.29602877
97cellular response to topologically incorrect protein (GO:0035967)3.29425128
98positive regulation of lymphocyte apoptotic process (GO:0070230)3.27948677
99pyrimidine nucleotide metabolic process (GO:0006220)3.27943968
100T cell apoptotic process (GO:0070231)3.27615318
101outer ear morphogenesis (GO:0042473)3.27352911
102post-embryonic morphogenesis (GO:0009886)3.26458622
103folic acid metabolic process (GO:0046655)3.26161257
104apoptotic process involved in morphogenesis (GO:0060561)3.25926549
105DNA replication-dependent nucleosome organization (GO:0034723)3.25578610
106DNA replication-dependent nucleosome assembly (GO:0006335)3.25578610
107purine nucleotide salvage (GO:0032261)3.25144133
108ER-nucleus signaling pathway (GO:0006984)3.24991021
109pyrimidine nucleotide biosynthetic process (GO:0006221)3.23247461
110regulation of hippo signaling (GO:0035330)3.21838502
111negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.20764259
112pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.20637226
113establishment of integrated proviral latency (GO:0075713)3.20323133
114purine deoxyribonucleotide catabolic process (GO:0009155)3.18210728
115cytoskeletal anchoring at plasma membrane (GO:0007016)3.16204724
116DNA unwinding involved in DNA replication (GO:0006268)3.13165722
117kinetochore assembly (GO:0051382)3.12618331
118nucleotide salvage (GO:0043173)3.12550296
119plasma membrane repair (GO:0001778)3.09934469
120regulation of fatty acid beta-oxidation (GO:0031998)3.09367240
121macromolecular complex disassembly (GO:0032984)3.08756741
122chaperone-mediated protein transport (GO:0072321)3.08158955
123retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.06566204
124IMP metabolic process (GO:0046040)3.05364131
125lymphocyte apoptotic process (GO:0070227)3.02970875
126pentose metabolic process (GO:0019321)3.02798804
127glucocorticoid receptor signaling pathway (GO:0042921)2.99963883
128regulation of SMAD protein import into nucleus (GO:0060390)2.99636558
129positive regulation of histone deacetylation (GO:0031065)2.99008972
130protein targeting to membrane (GO:0006612)2.98044959
131DNA replication checkpoint (GO:0000076)2.97929269
132maturation of SSU-rRNA (GO:0030490)2.97226977
133intracellular estrogen receptor signaling pathway (GO:0030520)2.95323159
134nucleoside transmembrane transport (GO:1901642)2.92853733
135nuclear envelope organization (GO:0006998)2.92493056
136positive regulation of protein oligomerization (GO:0032461)2.92422822
1372-deoxyribonucleotide metabolic process (GO:0009394)2.88696904
138positive regulation of protein homooligomerization (GO:0032464)2.88384050
139histone arginine methylation (GO:0034969)2.88266804
140protein retention in ER lumen (GO:0006621)2.86745233
141adenosine receptor signaling pathway (GO:0001973)2.84205308
142negative regulation of fatty acid transport (GO:2000192)2.84024556
143pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.83646031
144vesicle coating (GO:0006901)2.83397354
145polyamine biosynthetic process (GO:0006596)2.83157538
146rRNA processing (GO:0006364)2.79383867
147adherens junction assembly (GO:0034333)2.79356017
148activation of NF-kappaB-inducing kinase activity (GO:0007250)2.78921282
149protein maturation by protein folding (GO:0022417)2.78196889
150tricarboxylic acid metabolic process (GO:0072350)2.77492428
151response to endoplasmic reticulum stress (GO:0034976)2.77128556
152nuclear pore organization (GO:0006999)2.75141348
153protein insertion into membrane (GO:0051205)2.75013593
154polarized epithelial cell differentiation (GO:0030859)2.73635337
155pteridine-containing compound biosynthetic process (GO:0042559)2.73087850
156cellular response to glucose starvation (GO:0042149)2.72117576
157mesoderm formation (GO:0001707)2.71560848
158response to unfolded protein (GO:0006986)2.71206964
159collecting duct development (GO:0072044)2.69720567
160peptidyl-lysine dimethylation (GO:0018027)2.61727846
161intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.60970842
162corticosteroid receptor signaling pathway (GO:0031958)2.60482682
163regulation of translational elongation (GO:0006448)2.60186289
164response to topologically incorrect protein (GO:0035966)2.57311654
165alternative mRNA splicing, via spliceosome (GO:0000380)2.56774925
166tetrahydrofolate metabolic process (GO:0046653)2.56103977
167apoptotic process involved in development (GO:1902742)2.55601195
168regulation of early endosome to late endosome transport (GO:2000641)2.55524943
169nuclear pore complex assembly (GO:0051292)2.54513105
170cerebellar Purkinje cell layer development (GO:0021680)2.53602579
171hippo signaling (GO:0035329)2.52410368
172epithelial cell-cell adhesion (GO:0090136)2.52011886
173chaperone-mediated protein complex assembly (GO:0051131)2.48700263
174cellular response to epidermal growth factor stimulus (GO:0071364)2.47153545
175regulation of polysaccharide biosynthetic process (GO:0032885)2.46080231
176negative regulation of histone methylation (GO:0031061)2.46016624
177negative regulation of gene silencing (GO:0060969)2.45747426
1784-hydroxyproline metabolic process (GO:0019471)2.44736550
179epithelial cell fate commitment (GO:0072148)2.43111974
180membrane budding (GO:0006900)2.42549915
181apoptotic cell clearance (GO:0043277)2.41594379
182cellular hyperosmotic response (GO:0071474)2.41083399
183positive regulation of glycogen biosynthetic process (GO:0045725)2.39096965
184nucleobase biosynthetic process (GO:0046112)2.37361356
185pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.34453173
186UMP biosynthetic process (GO:0006222)2.34453173
187UMP metabolic process (GO:0046049)2.34453173

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human3.83358368
2HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.24532938
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.12282033
4MYC_22102868_ChIP-Seq_BL_Human3.06632139
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.06263957
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.98206339
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.88280093
8DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.65424378
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.59818575
10TP63_17297297_ChIP-ChIP_HaCaT_Human2.57530553
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.55971526
12RARG_19884340_ChIP-ChIP_MEFs_Mouse2.51033249
13ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.42575198
14POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.34882142
15FOXM1_23109430_ChIP-Seq_U2OS_Human2.31479338
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.30879308
17THAP11_20581084_ChIP-Seq_MESCs_Mouse2.25332957
18NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.17384149
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.08196834
20STAT6_21828071_ChIP-Seq_BEAS2B_Human2.05443986
21ZFP281_18757296_ChIP-ChIP_E14_Mouse1.97440920
22TET1_21451524_ChIP-Seq_MESCs_Mouse1.96622801
23ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.96108110
24CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.94575676
25TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.92943548
26ELK3_25401928_ChIP-Seq_HUVEC_Human1.85746618
27TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.85162081
28GABP_19822575_ChIP-Seq_HepG2_Human1.82283878
29SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.80864029
30CLOCK_20551151_ChIP-Seq_293T_Human1.78574249
31ATF3_27146783_Chip-Seq_COLON_Human1.78371784
32VDR_21846776_ChIP-Seq_THP-1_Human1.78364797
33EST1_17652178_ChIP-ChIP_JURKAT_Human1.76772563
34P68_20966046_ChIP-Seq_HELA_Human1.75952010
35CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.74977298
36TRIM28_21343339_ChIP-Seq_HEK293_Human1.71998427
37GABP_17652178_ChIP-ChIP_JURKAT_Human1.71153838
38CREB1_15753290_ChIP-ChIP_HEK293T_Human1.69865774
39MAF_26560356_Chip-Seq_TH2_Human1.66314355
40KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.66267198
41KDM2B_26808549_Chip-Seq_DND41_Human1.64167399
42PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.64002490
43DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.63715571
44DCP1A_22483619_ChIP-Seq_HELA_Human1.63197480
45KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.62150838
46XRN2_22483619_ChIP-Seq_HELA_Human1.60838731
47LXR_22292898_ChIP-Seq_THP-1_Human1.60591716
48RACK7_27058665_Chip-Seq_MCF-7_Human1.59001237
49SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.58491745
50* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.57484442
51ZNF263_19887448_ChIP-Seq_K562_Human1.57298887
52TCF3_18692474_ChIP-Seq_MEFs_Mouse1.56160936
53KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.55577871
54YY1_21170310_ChIP-Seq_MESCs_Mouse1.54557450
55KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.54233775
56KDM2B_26808549_Chip-Seq_SUP-B15_Human1.54058995
57KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.51281529
58MYC_19030024_ChIP-ChIP_MESCs_Mouse1.51112945
59NELFA_20434984_ChIP-Seq_ESCs_Mouse1.48633134
60KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.48213277
61SA1_27219007_Chip-Seq_ERYTHROID_Human1.47661382
62TFEB_21752829_ChIP-Seq_HELA_Human1.47610674
63CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.46379076
64PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.45604888
65TCF7_22412390_ChIP-Seq_EML_Mouse1.43936753
66KLF4_18555785_ChIP-Seq_MESCs_Mouse1.43095278
67NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.42775828
68SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.42534154
69HIF1A_21447827_ChIP-Seq_MCF-7_Human1.42321443
70CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.41484280
71ZFP281_27345836_Chip-Seq_ESCs_Mouse1.41237600
72ELF1_17652178_ChIP-ChIP_JURKAT_Human1.40040018
73TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.38671806
74CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.37508642
75TTF2_22483619_ChIP-Seq_HELA_Human1.37340577
76FOXP3_21729870_ChIP-Seq_TREG_Human1.37097285
77AR_21909140_ChIP-Seq_LNCAP_Human1.35514008
78NANOG_18555785_ChIP-Seq_MESCs_Mouse1.35312984
79STAT3_1855785_ChIP-Seq_MESCs_Mouse1.34900060
80CTCF_21964334_Chip-Seq_Bcells_Human1.33302009
81SRY_22984422_ChIP-ChIP_TESTIS_Rat1.31844641
82P300_27058665_Chip-Seq_ZR-75-30cells_Human1.31673926
83MYC_18358816_ChIP-ChIP_MESCs_Mouse1.31608224
84SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.30985087
85ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.30698194
86NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.30660896
87YY1_22570637_ChIP-Seq_MALME-3M_Human1.30544113
88RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.30051150
89FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.30007840
90SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.29611762
91CREB1_26743006_Chip-Seq_LNCaP_Human1.28526480
92BCL6_27268052_Chip-Seq_Bcells_Human1.28219637
93CIITA_25753668_ChIP-Seq_RAJI_Human1.28006132
94* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.27661095
95E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.24917646
96TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23079203
97TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.22609965
98CTCF_26484167_Chip-Seq_Bcells_Mouse1.22582495
99MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.22554423
100SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.22438452
101RARA_24833708_ChIP-Seq_LIVER_Mouse1.22198003
102SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.22043635
103* ERG_21242973_ChIP-ChIP_JURKAT_Human1.21721775
104ZFX_18555785_ChIP-Seq_MESCs_Mouse1.21420254
105BCOR_27268052_Chip-Seq_Bcells_Human1.21114729
106NOTCH1_21737748_ChIP-Seq_TLL_Human1.20912180
107CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.20232642
108POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.20190220
109FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.20117009
110SRF_21415370_ChIP-Seq_HL-1_Mouse1.19870716
111MYCN_18555785_ChIP-Seq_MESCs_Mouse1.19258687
112WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.18445989
113SA1_27219007_Chip-Seq_Bcells_Human1.18204014
114ELF1_20517297_ChIP-Seq_JURKAT_Human1.17649410
115SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.17523538
116KDM2B_26808549_Chip-Seq_JURKAT_Human1.16631382
117HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.16542201
118* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.15424814
119RARB_24833708_ChIP-Seq_LIVER_Mouse1.14773562
120CTCF_18555785_ChIP-Seq_MESCs_Mouse1.14268551
121CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.13847800
122CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.13091586
123TP53_22127205_ChIP-Seq_IMR90_Human1.12628303
124SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.12436006
125PU.1_20513432_ChIP-Seq_Bcells_Mouse1.12321625
126CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.12298804
127CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.12282255
128VDR_23849224_ChIP-Seq_CD4+_Human1.12175005
129MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.11828295
130GATA6_25053715_ChIP-Seq_YYC3_Human1.11737248
131KDM5A_27292631_Chip-Seq_BREAST_Human1.10442272
132CHD1_26751641_Chip-Seq_LNCaP_Human1.10373206
133ESR1_15608294_ChIP-ChIP_MCF-7_Human1.09776204
134KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.09738092
135CTCF_27219007_Chip-Seq_Bcells_Human1.09654262
136DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.09467367
137E2F1_18555785_ChIP-Seq_MESCs_Mouse1.08044598
138SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.08029899
139KDM2B_26808549_Chip-Seq_K562_Human1.06875322
140FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.06791375
141* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.05155532
142ETS1_20019798_ChIP-Seq_JURKAT_Human1.04584889
143E2F1_21310950_ChIP-Seq_MCF-7_Human1.03058767
144NANOG_21062744_ChIP-ChIP_HESCs_Human1.02329528
145NCOR1_26117541_ChIP-Seq_K562_Human1.02090744
146FOXP1_21924763_ChIP-Seq_HESCs_Human1.01739133
147TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01052908
148TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.99649937
149UTX_26944678_Chip-Seq_JUKART_Human0.99369404
150* NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.98881516
151KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.98400337
152* SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.97971277
153* POU5F1_16518401_ChIP-PET_MESCs_Mouse0.97886246
154E2F4_17652178_ChIP-ChIP_JURKAT_Human0.97781588
155MAF_26560356_Chip-Seq_TH1_Human0.97239401
156ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.96516372

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat5.18527120
2MP0010352_gastrointestinal_tract_polyps3.99146477
3MP0002877_abnormal_melanocyte_morpholog3.73269091
4MP0003283_abnormal_digestive_organ3.71287669
5MP0009333_abnormal_splenocyte_physiolog3.29508707
6MP0003705_abnormal_hypodermis_morpholog3.28882490
7MP0005076_abnormal_cell_differentiation3.18302013
8MP0002277_abnormal_respiratory_mucosa3.03588723
9MP0002163_abnormal_gland_morphology2.97893995
10MP0005451_abnormal_body_composition2.85925006
11MP0004233_abnormal_muscle_weight2.73585263
12MP0000013_abnormal_adipose_tissue2.71422518
13MP0003300_gastrointestinal_ulcer2.60697365
14MP0001849_ear_inflammation2.48975607
15MP0001873_stomach_inflammation2.28263306
16MP0008961_abnormal_basal_metabolism2.21176729
17MP0003763_abnormal_thymus_physiology2.16381905
18MP0003123_paternal_imprinting2.08496900
19MP0001919_abnormal_reproductive_system2.05449858
20MP0010094_abnormal_chromosome_stability2.04391783
21MP0000003_abnormal_adipose_tissue1.97686401
22MP0004957_abnormal_blastocyst_morpholog1.96594978
23MP0005501_abnormal_skin_physiology1.89772503
24MP0003941_abnormal_skin_development1.88512399
25MP0009780_abnormal_chondrocyte_physiolo1.88068525
26MP0002249_abnormal_larynx_morphology1.82665601
27MP0001730_embryonic_growth_arrest1.81982403
28MP0003566_abnormal_cell_adhesion1.81331708
29MP0004185_abnormal_adipocyte_glucose1.81207976
30MP0003453_abnormal_keratinocyte_physiol1.80763253
31MP0003693_abnormal_embryo_hatching1.78105353
32MP0002896_abnormal_bone_mineralization1.77356668
33MP0002132_abnormal_respiratory_system1.76372277
34MP0008058_abnormal_DNA_repair1.75772935
35MP0010307_abnormal_tumor_latency1.69407361
36MP0000678_abnormal_parathyroid_gland1.62915277
37MP0003806_abnormal_nucleotide_metabolis1.62648177
38MP0004043_abnormal_pH_regulation1.62089883
39MP0000049_abnormal_middle_ear1.59860162
40MP0004133_heterotaxia1.59146015
41MP0010234_abnormal_vibrissa_follicle1.58725842
42MP0000733_abnormal_muscle_development1.57766387
43MP0001346_abnormal_lacrimal_gland1.54447640
44MP0000537_abnormal_urethra_morphology1.54060841
45MP0004197_abnormal_fetal_growth/weight/1.49309842
46MP0004742_abnormal_vestibular_system1.45803743
47MP0002736_abnormal_nociception_after1.44442884
48MP0002234_abnormal_pharynx_morphology1.44134820
49MP0002909_abnormal_adrenal_gland1.43026797
50MP0009672_abnormal_birth_weight1.42740435
51MP0002084_abnormal_developmental_patter1.42605180
52MP0002089_abnormal_postnatal_growth/wei1.42347180
53MP0005375_adipose_tissue_phenotype1.41600528
54MP0000750_abnormal_muscle_regeneration1.40285432
55MP0005257_abnormal_intraocular_pressure1.40250211
56MP0000313_abnormal_cell_death1.39839422
57MP0002269_muscular_atrophy1.39672765
58MP0000747_muscle_weakness1.39046497
59MP0004858_abnormal_nervous_system1.35436830
60MP0005666_abnormal_adipose_tissue1.34390222
61MP0000372_irregular_coat_pigmentation1.33049200
62MP0000350_abnormal_cell_proliferation1.32400263
63MP0003186_abnormal_redox_activity1.31461594
64MP0005623_abnormal_meninges_morphology1.31101627
65MP0001188_hyperpigmentation1.30650207
66MP0005332_abnormal_amino_acid1.27280741
67MP0008004_abnormal_stomach_pH1.24155343
68MP0003183_abnormal_peptide_metabolism1.24117741
69MP0008438_abnormal_cutaneous_collagen1.23937158
70MP0005058_abnormal_lysosome_morphology1.23709425
71MP0001348_abnormal_lacrimal_gland1.23293697
72MP0001697_abnormal_embryo_size1.23183063
73MP0003786_premature_aging1.23113065
74MP0002080_prenatal_lethality1.22537066
75MP0002796_impaired_skin_barrier1.22241065
76MP0003890_abnormal_embryonic-extraembry1.22168387
77MP0002085_abnormal_embryonic_tissue1.21878703
78MP0001672_abnormal_embryogenesis/_devel1.21243276
79MP0005380_embryogenesis_phenotype1.21243276
80MP0002088_abnormal_embryonic_growth/wei1.20801600
81MP0003984_embryonic_growth_retardation1.20618886
82MP0001661_extended_life_span1.20176472
83MP0003119_abnormal_digestive_system1.20065358
84MP0005171_absent_coat_pigmentation1.18921221
85MP0005023_abnormal_wound_healing1.16818911
86MP0001944_abnormal_pancreas_morphology1.15040669
87MP0009703_decreased_birth_body1.13856379
88MP0004264_abnormal_extraembryonic_tissu1.12935669
89MP0003077_abnormal_cell_cycle1.12254998
90MP0005379_endocrine/exocrine_gland_phen1.11674424
91MP0000428_abnormal_craniofacial_morphol1.11542092
92MP0000858_altered_metastatic_potential1.09095482
93MP0008932_abnormal_embryonic_tissue1.06958631
94MP0001756_abnormal_urination1.06655403
95MP0009278_abnormal_bone_marrow1.06425798
96MP0002168_other_aberrant_phenotype1.05911257
97MP0006036_abnormal_mitochondrial_physio1.05425295
98MP0005408_hypopigmentation1.04561495
99MP0003172_abnormal_lysosome_physiology1.03248112
100MP0003787_abnormal_imprinting1.02581075
101MP0002086_abnormal_extraembryonic_tissu1.02225701
102MP0002693_abnormal_pancreas_physiology1.00580769
103MP0001542_abnormal_bone_strength1.00400945
104MP0004947_skin_inflammation1.00215573
105MP0002210_abnormal_sex_determination0.99933850
106MP0003111_abnormal_nucleus_morphology0.97669425
107MP0000534_abnormal_ureter_morphology0.97179440
108MP0005310_abnormal_salivary_gland0.96430990
109MP0001986_abnormal_taste_sensitivity0.96178660
110MP0010030_abnormal_orbit_morphology0.95232004
111MP0010386_abnormal_urinary_bladder0.95197601
112MP0000516_abnormal_urinary_system0.94794547
113MP0005367_renal/urinary_system_phenotyp0.94794547
114MP0001299_abnormal_eye_distance/0.93587231
115MP0000681_abnormal_thyroid_gland0.92853357
116MP0000538_abnormal_urinary_bladder0.92523080
117MP0002722_abnormal_immune_system0.90906248
118MP0009643_abnormal_urine_homeostasis0.89599934
119MP0002160_abnormal_reproductive_system0.89577576
120MP0002078_abnormal_glucose_homeostasis0.89323573
121MP0002697_abnormal_eye_size0.89025283
122MP0005670_abnormal_white_adipose0.88679130
123MP0000759_abnormal_skeletal_muscle0.88391368
124MP0003091_abnormal_cell_migration0.87013551
125MP0008057_abnormal_DNA_replication0.86951617
126MP0002111_abnormal_tail_morphology0.86936341
127MP0001216_abnormal_epidermal_layer0.86114267
128MP0006035_abnormal_mitochondrial_morpho0.85486896
129MP0001191_abnormal_skin_condition0.85296889
130MP0005275_abnormal_skin_tensile0.84948764
131MP0008770_decreased_survivor_rate0.83782664
132MP0000490_abnormal_crypts_of0.82225757
133MP0005389_reproductive_system_phenotype0.82147255
134MP0003942_abnormal_urinary_system0.81594450
135MP0003315_abnormal_perineum_morphology0.81209716
136MP0005423_abnormal_somatic_nervous0.81142098
137MP0001764_abnormal_homeostasis0.80958770
138MP0000762_abnormal_tongue_morphology0.80892865
139MP0005508_abnormal_skeleton_morphology0.80458101
140MP0002019_abnormal_tumor_incidence0.80393464
141MP0004270_analgesia0.79466636
142MP0008875_abnormal_xenobiotic_pharmacok0.78613549
143MP0000751_myopathy0.78586629
144MP0002398_abnormal_bone_marrow0.78411695
145MP0009379_abnormal_foot_pigmentation0.77237203
146MP0000569_abnormal_digit_pigmentation0.76228807
147MP0005220_abnormal_exocrine_pancreas0.75564038
148MP0001145_abnormal_male_reproductive0.75319161
149MP0006054_spinal_hemorrhage0.75092905
150MP0002138_abnormal_hepatobiliary_system0.74727793
151* MP0002429_abnormal_blood_cell0.74551064
152MP0005330_cardiomyopathy0.74283746
153MP0003935_abnormal_craniofacial_develop0.74247216
154MP0003121_genomic_imprinting0.72889683
155MP0005410_abnormal_fertilization0.72463077
156MP0004087_abnormal_muscle_fiber0.72447174
157MP0000367_abnormal_coat/_hair0.72444314
158MP0002177_abnormal_outer_ear0.72225661
159MP0009053_abnormal_anal_canal0.71288942
160MP0003136_yellow_coat_color0.71013860
161MP0008007_abnormal_cellular_replicative0.70716231
162MP0002938_white_spotting0.70643329
163MP0000703_abnormal_thymus_morphology0.70073835
164MP0005319_abnormal_enzyme/_coenzyme0.69956804
165MP0002396_abnormal_hematopoietic_system0.67488668
166MP0005621_abnormal_cell_physiology0.67386348
167MP0005377_hearing/vestibular/ear_phenot0.67028599
168MP0003878_abnormal_ear_physiology0.67028599
169MP0000358_abnormal_cell_content/0.66930131
170MP0008469_abnormal_protein_level0.64737601

Predicted human phenotypes

RankGene SetZ-score
1Progressive muscle weakness (HP:0003323)5.25474247
2Poikiloderma (HP:0001029)4.74021741
3Sensory axonal neuropathy (HP:0003390)4.51766610
4Squamous cell carcinoma (HP:0002860)4.29680392
5Double outlet right ventricle (HP:0001719)4.04123364
6Congenital malformation of the right heart (HP:0011723)4.04123364
7Breast hypoplasia (HP:0003187)3.94323197
8Testicular atrophy (HP:0000029)3.94291498
9Increased intramyocellular lipid droplets (HP:0012240)3.85927903
10Ragged-red muscle fibers (HP:0003200)3.71127400
11Increased neuronal autofluorescent lipopigment (HP:0002074)3.64865727
12Increased muscle lipid content (HP:0009058)3.60485434
13Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.58395902
14Fragile nails (HP:0001808)3.34454117
15Reticulocytopenia (HP:0001896)3.26874475
16Macrocytic anemia (HP:0001972)3.23270152
17Birth length less than 3rd percentile (HP:0003561)3.20129852
18Abnormality of cells of the erythroid lineage (HP:0012130)3.18612610
19Spinal muscular atrophy (HP:0007269)3.17875173
20Back pain (HP:0003418)3.11311233
21Increased cerebral lipofuscin (HP:0011813)3.04251727
22Gout (HP:0001997)3.02713179
23Decreased electroretinogram (ERG) amplitude (HP:0000654)3.01727090
24Renal Fanconi syndrome (HP:0001994)2.99959701
25Abnormal number of erythroid precursors (HP:0012131)2.95180807
26Abnormality of the costochondral junction (HP:0000919)2.93103234
27Aplasia of the musculature (HP:0100854)2.91599702
28Multiple enchondromatosis (HP:0005701)2.90274676
29Visual hallucinations (HP:0002367)2.89348212
30Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.88601240
31Abnormality of the aortic arch (HP:0012303)2.88436621
32Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.88237485
33Entropion (HP:0000621)2.87736237
34Decreased activity of mitochondrial respiratory chain (HP:0008972)2.87516712
35Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.87516712
36Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.87041037
37Transposition of the great arteries (HP:0001669)2.85102615
38Abnormal connection of the cardiac segments (HP:0011545)2.85102615
39Abnormal ventriculo-arterial connection (HP:0011563)2.85102615
40Progressive external ophthalmoplegia (HP:0000590)2.82143022
41Prolonged neonatal jaundice (HP:0006579)2.79628283
42Protrusio acetabuli (HP:0003179)2.76346748
43Ankle contracture (HP:0006466)2.74992909
44Abnormality of DNA repair (HP:0003254)2.70086520
45Hypoplastic heart (HP:0001961)2.68936745
46Abnormal trabecular bone morphology (HP:0100671)2.67516937
47Sclerocornea (HP:0000647)2.66186246
48Abnormality of the lower motor neuron (HP:0002366)2.65594089
49Distal upper limb amyotrophy (HP:0007149)2.64696994
50Upper limb amyotrophy (HP:0009129)2.64696994
51Trismus (HP:0000211)2.63443504
52Cutaneous melanoma (HP:0012056)2.61760810
53Abnormality of placental membranes (HP:0011409)2.60100652
54Amniotic constriction ring (HP:0009775)2.60100652
55Hypoplastic left heart (HP:0004383)2.59967497
56Hand muscle atrophy (HP:0009130)2.59890329
57Dysphonia (HP:0001618)2.57731855
58Recurrent bacterial skin infections (HP:0005406)2.55320875
59Impulsivity (HP:0100710)2.53600492
60Truncus arteriosus (HP:0001660)2.53397070
61Increased hepatocellular lipid droplets (HP:0006565)2.49381101
62Rough bone trabeculation (HP:0100670)2.48246613
63Hypergonadotropic hypogonadism (HP:0000815)2.44505072
64Difficulty climbing stairs (HP:0003551)2.43739894
65Cerebral aneurysm (HP:0004944)2.43157039
66Angiofibromas (HP:0010615)2.41478588
67Adenoma sebaceum (HP:0009720)2.41478588
68Lipid accumulation in hepatocytes (HP:0006561)2.41314888
69Mesangial abnormality (HP:0001966)2.40395173
70Abnormality of the intrinsic pathway (HP:0010989)2.38511330
71Degeneration of anterior horn cells (HP:0002398)2.36694431
72Abnormality of the anterior horn cell (HP:0006802)2.36694431
73Increased density of long bones (HP:0006392)2.31711990
74Hypercortisolism (HP:0001578)2.29949166
75Colon cancer (HP:0003003)2.29259771
76Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.27929545
77Pallor (HP:0000980)2.27777991
78Ependymoma (HP:0002888)2.27369678
79Chromosomal breakage induced by crosslinking agents (HP:0003221)2.26597117
80Metaphyseal cupping (HP:0003021)2.24380055
81EMG: neuropathic changes (HP:0003445)2.23366581
82Ulnar bowing (HP:0003031)2.22886015
83Shallow orbits (HP:0000586)2.22027795
84Pelvic girdle muscle weakness (HP:0003749)2.20762034
85Abnormal mitochondria in muscle tissue (HP:0008316)2.19454418
86Cervical subluxation (HP:0003308)2.19413168
87Vertebral arch anomaly (HP:0008438)2.19398209
88Spastic diplegia (HP:0001264)2.19098198
89Respiratory difficulties (HP:0002880)2.18343975
90Frequent falls (HP:0002359)2.16658768
91Exercise intolerance (HP:0003546)2.16472081
92Unilateral renal agenesis (HP:0000122)2.15589096
93Chromsome breakage (HP:0040012)2.14293488
94Progressive visual loss (HP:0000529)2.13467721
95Widely patent fontanelles and sutures (HP:0004492)2.12376738
96Congenital ichthyosiform erythroderma (HP:0007431)2.11930194
97Missing ribs (HP:0000921)2.08621257
98Aplasia/Hypoplasia of the sacrum (HP:0008517)2.08148874
99Slender build (HP:0001533)2.08106855
100Ankyloglossia (HP:0010296)2.08106557
101Cerebral hypomyelination (HP:0006808)2.08050883
102Neoplasm of the heart (HP:0100544)2.07829157
103Macroorchidism (HP:0000053)2.07138497
104Abnormality of the astrocytes (HP:0100707)2.06420863
105Astrocytoma (HP:0009592)2.06420863
106Stridor (HP:0010307)2.06419998
107Genu recurvatum (HP:0002816)2.05184948
108Hyperthyroidism (HP:0000836)2.04668724
109Ulnar deviation of the wrist (HP:0003049)2.04261526
110Hypoplasia of the pons (HP:0012110)2.04169443
111Hyperinsulinemic hypoglycemia (HP:0000825)2.03353321
112Thin bony cortex (HP:0002753)2.03239583
113Abnormality of liposaccharide metabolism (HP:0010968)2.02923987
114Abnormality of glycosphingolipid metabolism (HP:0004343)2.02923987
115Abnormality of glycolipid metabolism (HP:0010969)2.02923987
116Hyperacusis (HP:0010780)2.02492126
117Hyperparathyroidism (HP:0000843)2.02317539
118Prolonged partial thromboplastin time (HP:0003645)2.01708107
119Absent thumb (HP:0009777)2.01441626
120Abnormality of the calcaneus (HP:0008364)2.01251625
121Long toe (HP:0010511)2.00441124
122Basal cell carcinoma (HP:0002671)1.99229204
123Preauricular pit (HP:0004467)1.98772905
124Periauricular skin pits (HP:0100277)1.98772905
125Atrophy/Degeneration involving motor neurons (HP:0007373)1.98593780
126Aplasia/Hypoplasia involving the musculature (HP:0001460)1.97679671
127Bowel diverticulosis (HP:0005222)1.97186537
128Abnormality of abdominal situs (HP:0011620)1.95386692
129Abdominal situs inversus (HP:0003363)1.95386692
130Abnormality of oral frenula (HP:0000190)1.95196055
131Turricephaly (HP:0000262)1.95189051
132Ketoacidosis (HP:0001993)1.94386085
133Poor eye contact (HP:0000817)1.94097011
134Microvesicular hepatic steatosis (HP:0001414)1.93964225
135Increased connective tissue (HP:0009025)1.90129262
136Enlarged penis (HP:0000040)1.88586731
137Pterygium (HP:0001059)1.87584545
138Abnormality of the hip-girdle musculature (HP:0001445)1.87446494
139Abnormality of the musculature of the pelvis (HP:0001469)1.87446494
140Amblyopia (HP:0000646)1.87213998
141Cortical dysplasia (HP:0002539)1.86325308
142Scapular winging (HP:0003691)1.85489276
143Intestinal polyp (HP:0005266)1.84796500
144Seborrheic dermatitis (HP:0001051)1.84464501
145Hypoplastic pelvis (HP:0008839)1.83724262
146Aneurysm (HP:0002617)1.83654905
147Intestinal polyposis (HP:0200008)1.82409670
148Type 1 muscle fiber predominance (HP:0003803)1.82214535
149Asymmetric septal hypertrophy (HP:0001670)1.81767284
150Increased serum lactate (HP:0002151)1.79962376
151Abnormalities of placenta or umbilical cord (HP:0001194)1.79370734
152Elevated erythrocyte sedimentation rate (HP:0003565)1.79323059
153Severe short stature (HP:0003510)1.78730819
154Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.78637403
155Short 4th metacarpal (HP:0010044)1.78637403
156Mucopolysacchariduria (HP:0008155)1.78273279
157Urinary glycosaminoglycan excretion (HP:0003541)1.78273279
158Delayed epiphyseal ossification (HP:0002663)1.76809536
159Vertebral fusion (HP:0002948)1.76693962
160Wrist flexion contracture (HP:0001239)1.76618687
161Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.76288182
162Spastic paraparesis (HP:0002313)1.76176288
163Selective tooth agenesis (HP:0001592)1.76165429
164Microretrognathia (HP:0000308)1.74813000
165Palmoplantar hyperkeratosis (HP:0000972)1.74380253
166Abnormality of the pons (HP:0007361)1.73789020
167Mitochondrial inheritance (HP:0001427)1.73427304
168Hyporeflexia of lower limbs (HP:0002600)1.73237442
169Aplasia/hypoplasia of the humerus (HP:0006507)1.72695261
170Fibroma (HP:0010614)1.72676930
171Skin tags (HP:0010609)1.72170520
172Resting tremor (HP:0002322)1.71623964
173Shoulder girdle muscle weakness (HP:0003547)1.70978299
174Exostoses (HP:0100777)1.70778594
175Premature rupture of membranes (HP:0001788)1.70143416
176Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.68120196
177Vertebral hypoplasia (HP:0008417)1.68120196
178Hypoglycemic coma (HP:0001325)1.68052975
179Preauricular skin tag (HP:0000384)1.67365081
180Mildly elevated creatine phosphokinase (HP:0008180)1.66531200
181Muscle fiber splitting (HP:0003555)1.65894039
182Limb-girdle muscle atrophy (HP:0003797)1.65792036
183Agitation (HP:0000713)1.65629931
184Late onset (HP:0003584)1.65380177
185Long palpebral fissure (HP:0000637)1.64840176
186Glossoptosis (HP:0000162)1.62444175
187Palmar hyperkeratosis (HP:0010765)1.62132023
188Mitral valve prolapse (HP:0001634)1.62043240
189Overlapping toe (HP:0001845)1.60917925
190Rib fusion (HP:0000902)1.60865854
191Broad thumb (HP:0011304)1.60836960
192Dilatation of the ascending aorta (HP:0005111)1.60716039
193Peritonitis (HP:0002586)1.59281049
194Lymphangioma (HP:0100764)1.58131929

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME25.65317422
2SMG14.73116088
3TAF13.90646837
4TAOK13.69024156
5SCYL23.47276912
6TRIB33.46203930
7PKN23.36515360
8EEF2K3.33863772
9MAP3K103.20686936
10VRK23.00357689
11PRKD32.93707035
12STK162.85936475
13IRAK32.63068683
14ERN12.52010457
15STK242.48798105
16PTK62.46417239
17PASK2.40892924
18CDK122.39361093
19TESK22.22358404
20MST42.17746715
21TTN2.14819689
22LATS22.07906483
23EPHA22.02376987
24MAPKAPK31.99406851
25BRAF1.96766262
26MAPK151.68967730
27TESK11.66327598
28IRAK21.65356248
29SIK11.64739616
30MAP2K31.62932529
31MAP4K11.60555843
32PRPF4B1.58907115
33ABL21.58346928
34PAK41.54608982
35PIM21.51299460
36ZAK1.50469456
37CHEK21.49974687
38RPS6KB21.49637167
39MAP3K111.44565399
40TAOK21.43567377
41ALK1.42397041
42EIF2AK11.40155286
43MTOR1.35306801
44MAPK111.34571689
45CAMK1D1.29633818
46LRRK21.26287104
47PDGFRA1.24651560
48MAP3K21.24103972
49MAP3K91.12216941
50LIMK11.09817162
51KSR21.06032642
52NME10.99092768
53WNK40.98836013
54DAPK20.95596255
55TTK0.95143096
56DYRK20.95127551
57PTK20.94833066
58CDK190.94705162
59DYRK1B0.92925647
60NEK20.92142498
61MAP3K80.91944717
62WNK30.91152764
63NEK10.90813754
64CAMK1G0.90583061
65MAP2K20.88485014
66BMX0.87634085
67IKBKB0.87468788
68DYRK30.87263371
69BRSK10.86259430
70CSNK1G30.85870333
71BUB10.85767184
72TLK10.84258985
73MARK10.83468323
74FGFR10.83438860
75STK100.83016415
76CSNK1A1L0.82801172
77CDK60.81131060
78PRKCI0.80756100
79RIPK10.79220654
80BRD40.77975785
81STK40.77937626
82ATR0.77717079
83ARAF0.76923693
84TSSK60.73838205
85TYK20.73224466
86CDC70.72771331
87PDGFRB0.71988020
88PAK30.70699845
89ICK0.70132897
90GRK60.69695628
91PAK20.68914133
92MAP3K10.68140086
93RET0.67971343
94NTRK10.67427721
95VRK10.64268937
96CSNK1G10.62493667
97DAPK10.61730429
98MARK20.61061994
99MAP2K10.60451095
100AURKB0.60388432
101MAP3K30.60067894
102CDK80.59294511
103HIPK20.58137290
104PBK0.57758456
105BLK0.57426848
106PRKCH0.56671725
107FRK0.56306609
108IRAK40.54960556
109CDC42BPA0.54431205
110NUAK10.53822612
111PLK10.53325319
112RPS6KA20.53152248
113MAPKAPK50.52746003
114RPS6KA10.52293270
115ITK0.52061019
116RPS6KC10.51744993
117RPS6KL10.51744993
118FER0.50024577
119CHEK10.48351537
120TBK10.48186735
121LATS10.47911461
122TGFBR10.47641507
123RPS6KA50.47398422
124CSNK1E0.46675414
125CDK40.45954254
126CDK70.45674812
127CSNK1G20.45634803
128PAK60.45314307
129AURKA0.44494119
130PDK20.44363258
131DDR20.43837749
132IRAK10.43535973
133ERBB40.43283138
134TYRO30.43259120
135PRKD10.43000061
136RPS6KA60.42447544
137DAPK30.42081504
138DMPK0.41804939
139CDK90.41762514
140CSNK2A20.41575004
141IKBKE0.41383286
142BCKDK0.41073855
143AKT20.40188904
144MUSK0.39868343
145CDK20.39795913
146KDR0.39790454
147EIF2AK20.38867041
148MINK10.38835979
149PAK10.38555261
150PRKDC0.37715951
151PIM10.37324372
152ILK0.37142992
153FGFR40.36138762
154GSK3A0.35882035
155RPS6KA40.35588974
156CHUK0.34768411
157UHMK10.34593370
158MAP3K70.34466439
159FLT30.33959550
160PLK30.33951946
161MAPK90.32613682
162CDK140.30840812
163SIK20.30267038

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041225.66415077
2Ribosome_Homo sapiens_hsa030105.13890442
3DNA replication_Homo sapiens_hsa030304.09517004
4Maturity onset diabetes of the young_Homo sapiens_hsa049502.74388159
5Proteasome_Homo sapiens_hsa030502.58490170
6Mismatch repair_Homo sapiens_hsa034302.52378070
72-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.49260719
8Pyrimidine metabolism_Homo sapiens_hsa002402.42502800
9Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.27928149
10Base excision repair_Homo sapiens_hsa034102.23634583
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.15549109
12Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.07100645
13One carbon pool by folate_Homo sapiens_hsa006702.05109644
14Fanconi anemia pathway_Homo sapiens_hsa034602.03803120
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.99149056
16Selenocompound metabolism_Homo sapiens_hsa004501.94794893
17Type II diabetes mellitus_Homo sapiens_hsa049301.92538807
18Phenylalanine metabolism_Homo sapiens_hsa003601.91800863
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.88086313
20Bladder cancer_Homo sapiens_hsa052191.87160101
21Sulfur metabolism_Homo sapiens_hsa009201.79761358
22mTOR signaling pathway_Homo sapiens_hsa041501.77499288
23Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.76814016
24Nucleotide excision repair_Homo sapiens_hsa034201.72402086
25Chronic myeloid leukemia_Homo sapiens_hsa052201.60818054
26Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.59593621
27Central carbon metabolism in cancer_Homo sapiens_hsa052301.55395522
28Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.54886289
29Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.52915560
30RNA transport_Homo sapiens_hsa030131.52881937
31Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.51706569
32Insulin resistance_Homo sapiens_hsa049311.51519558
33Purine metabolism_Homo sapiens_hsa002301.44915148
34Endometrial cancer_Homo sapiens_hsa052131.42303760
35Glioma_Homo sapiens_hsa052141.37238850
36Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.35274643
37Proteoglycans in cancer_Homo sapiens_hsa052051.33506473
38Parkinsons disease_Homo sapiens_hsa050121.29842973
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.29767129
40Thyroid cancer_Homo sapiens_hsa052161.29619856
41Lysine degradation_Homo sapiens_hsa003101.28999016
42Biosynthesis of amino acids_Homo sapiens_hsa012301.27850589
43Oxidative phosphorylation_Homo sapiens_hsa001901.27440454
44Vitamin B6 metabolism_Homo sapiens_hsa007501.27082300
45Homologous recombination_Homo sapiens_hsa034401.26153838
46Acute myeloid leukemia_Homo sapiens_hsa052211.23674835
47Neurotrophin signaling pathway_Homo sapiens_hsa047221.23607009
48Hippo signaling pathway_Homo sapiens_hsa043901.23122629
49Adherens junction_Homo sapiens_hsa045201.22193268
50Glucagon signaling pathway_Homo sapiens_hsa049221.22053614
51Insulin signaling pathway_Homo sapiens_hsa049101.19845447
52Huntingtons disease_Homo sapiens_hsa050161.18853981
53Cyanoamino acid metabolism_Homo sapiens_hsa004601.17135151
54Glutathione metabolism_Homo sapiens_hsa004801.16463163
55Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.15045356
56Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.13107541
57Basal cell carcinoma_Homo sapiens_hsa052171.13047116
58Histidine metabolism_Homo sapiens_hsa003401.12482737
59Longevity regulating pathway - mammal_Homo sapiens_hsa042111.12029593
60Colorectal cancer_Homo sapiens_hsa052101.10557801
61MicroRNAs in cancer_Homo sapiens_hsa052061.06832142
62Insulin secretion_Homo sapiens_hsa049111.04635218
63Carbohydrate digestion and absorption_Homo sapiens_hsa049731.04581281
64Primary immunodeficiency_Homo sapiens_hsa053401.04002382
65Estrogen signaling pathway_Homo sapiens_hsa049151.03456378
66AMPK signaling pathway_Homo sapiens_hsa041521.03045769
67Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.01919234
68Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.01152850
69Focal adhesion_Homo sapiens_hsa045101.01095071
70Alzheimers disease_Homo sapiens_hsa050101.00254311
71Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.98686149
72Pentose phosphate pathway_Homo sapiens_hsa000300.98226563
73Viral carcinogenesis_Homo sapiens_hsa052030.95786702
74Prion diseases_Homo sapiens_hsa050200.93961687
75HIF-1 signaling pathway_Homo sapiens_hsa040660.93514720
76Spliceosome_Homo sapiens_hsa030400.92294243
77Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.91885365
78Fructose and mannose metabolism_Homo sapiens_hsa000510.91601293
79Adipocytokine signaling pathway_Homo sapiens_hsa049200.91266044
80Non-small cell lung cancer_Homo sapiens_hsa052230.91001556
81Carbon metabolism_Homo sapiens_hsa012000.90821538
82Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.90226900
83Prostate cancer_Homo sapiens_hsa052150.89480517
84Vibrio cholerae infection_Homo sapiens_hsa051100.87021018
85RNA polymerase_Homo sapiens_hsa030200.87020998
86Epstein-Barr virus infection_Homo sapiens_hsa051690.86651750
87AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.83124461
88Renal cell carcinoma_Homo sapiens_hsa052110.82598764
89FoxO signaling pathway_Homo sapiens_hsa040680.82315088
90Prolactin signaling pathway_Homo sapiens_hsa049170.81628057
91Fatty acid elongation_Homo sapiens_hsa000620.79341871
92Steroid biosynthesis_Homo sapiens_hsa001000.79187148
93mRNA surveillance pathway_Homo sapiens_hsa030150.78881846
94Tight junction_Homo sapiens_hsa045300.78030798
95Bile secretion_Homo sapiens_hsa049760.77996306
96Amoebiasis_Homo sapiens_hsa051460.76857249
97RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.76778176
98Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.75995949
99p53 signaling pathway_Homo sapiens_hsa041150.72947329
100Hedgehog signaling pathway_Homo sapiens_hsa043400.71967558
101VEGF signaling pathway_Homo sapiens_hsa043700.70497861
102Small cell lung cancer_Homo sapiens_hsa052220.70181420
103Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.69903673
104Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.69753104
105HTLV-I infection_Homo sapiens_hsa051660.69572264
106Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69277571
107Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.68384406
108Galactose metabolism_Homo sapiens_hsa000520.67679723
109Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.67454823
110Oocyte meiosis_Homo sapiens_hsa041140.67236512
111NF-kappa B signaling pathway_Homo sapiens_hsa040640.67036508
112Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.66340270
113Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.66041410
114Melanoma_Homo sapiens_hsa052180.64961433
115Metabolic pathways_Homo sapiens_hsa011000.64299912
116Arginine and proline metabolism_Homo sapiens_hsa003300.64107191
117Pancreatic cancer_Homo sapiens_hsa052120.64063845
118ErbB signaling pathway_Homo sapiens_hsa040120.63266626
119Leukocyte transendothelial migration_Homo sapiens_hsa046700.63239745
120Thyroid hormone synthesis_Homo sapiens_hsa049180.63183790
121Sphingolipid metabolism_Homo sapiens_hsa006000.62073671
122Cell cycle_Homo sapiens_hsa041100.62046498
123Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.60549428
124Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.59412969
125Melanogenesis_Homo sapiens_hsa049160.58089933
126Glycosaminoglycan degradation_Homo sapiens_hsa005310.57406149
127Notch signaling pathway_Homo sapiens_hsa043300.56673023
128N-Glycan biosynthesis_Homo sapiens_hsa005100.55579935
129Tyrosine metabolism_Homo sapiens_hsa003500.55294017
130Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.53748295
131Fatty acid biosynthesis_Homo sapiens_hsa000610.53287586
132Protein digestion and absorption_Homo sapiens_hsa049740.52730145
133Non-homologous end-joining_Homo sapiens_hsa034500.52218334
134Herpes simplex infection_Homo sapiens_hsa051680.51724986
135Cysteine and methionine metabolism_Homo sapiens_hsa002700.50977832
136Apoptosis_Homo sapiens_hsa042100.49943061
137Folate biosynthesis_Homo sapiens_hsa007900.48797877
138Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48503169
139RNA degradation_Homo sapiens_hsa030180.48267284
140Arginine biosynthesis_Homo sapiens_hsa002200.47748855
141Dorso-ventral axis formation_Homo sapiens_hsa043200.47199030
142Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.45608778
143Hepatitis C_Homo sapiens_hsa051600.44955952
144Endocytosis_Homo sapiens_hsa041440.44488533
145Pathways in cancer_Homo sapiens_hsa052000.44282116
146Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44180500
147Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34768090
148Basal transcription factors_Homo sapiens_hsa030220.34254030
149Hepatitis B_Homo sapiens_hsa051610.30546322
150Measles_Homo sapiens_hsa051620.28637053
151T cell receptor signaling pathway_Homo sapiens_hsa046600.25358331
152Lysosome_Homo sapiens_hsa041420.23883669
153Other glycan degradation_Homo sapiens_hsa005110.23539340
154NOD-like receptor signaling pathway_Homo sapiens_hsa046210.22697823
155Drug metabolism - other enzymes_Homo sapiens_hsa009830.21092621
156Peroxisome_Homo sapiens_hsa041460.20299140
157Wnt signaling pathway_Homo sapiens_hsa043100.17893108
158Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.17797795
159Toll-like receptor signaling pathway_Homo sapiens_hsa046200.17746410

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