GALT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Galactose-1-phosphate uridyl transferase (GALT) catalyzes the second step of the Leloir pathway of galactose metabolism, namely the conversion of UDP-glucose + galactose-1-phosphate to glucose-1-phosphate + UDP-galactose. The absence of this enzyme results in classic galactosemia in humans and can be fatal in the newborn period if lactose is not removed from the diet. The pathophysiology of galactosemia has not been clearly defined. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.14301901
2L-phenylalanine catabolic process (GO:0006559)6.14301901
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.10484164
4L-phenylalanine metabolic process (GO:0006558)6.10484164
5aromatic amino acid family catabolic process (GO:0009074)5.69148796
6tryptophan catabolic process (GO:0006569)5.40224681
7indole-containing compound catabolic process (GO:0042436)5.40224681
8indolalkylamine catabolic process (GO:0046218)5.40224681
9kynurenine metabolic process (GO:0070189)5.37805373
10glyoxylate metabolic process (GO:0046487)5.33714001
11triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.33619099
12lysine metabolic process (GO:0006553)4.98740867
13lysine catabolic process (GO:0006554)4.98740867
14bile acid biosynthetic process (GO:0006699)4.97183376
15tryptophan metabolic process (GO:0006568)4.93565082
16high-density lipoprotein particle remodeling (GO:0034375)4.74016487
17oxaloacetate metabolic process (GO:0006107)4.72992947
18cysteine metabolic process (GO:0006534)4.64513486
19serine family amino acid catabolic process (GO:0009071)4.61082428
20urea cycle (GO:0000050)4.59513315
21urea metabolic process (GO:0019627)4.59513315
22sulfur amino acid catabolic process (GO:0000098)4.58429906
23fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.53899115
24negative regulation of fibrinolysis (GO:0051918)4.50141092
25amino-acid betaine metabolic process (GO:0006577)4.48123965
26regulation of fibrinolysis (GO:0051917)4.30200678
27nitrogen cycle metabolic process (GO:0071941)4.29477557
28exogenous drug catabolic process (GO:0042738)4.29117591
292-oxoglutarate metabolic process (GO:0006103)4.28931484
30alpha-amino acid catabolic process (GO:1901606)4.26306193
31epoxygenase P450 pathway (GO:0019373)4.21514274
32regulation of cholesterol esterification (GO:0010872)4.16571252
33glycine metabolic process (GO:0006544)4.15582107
34alpha-linolenic acid metabolic process (GO:0036109)4.13627482
35aromatic amino acid family metabolic process (GO:0009072)4.12786300
36cellular ketone body metabolic process (GO:0046950)4.12680702
37bile acid metabolic process (GO:0008206)4.11353443
38regulation of protein activation cascade (GO:2000257)4.06893468
39coenzyme catabolic process (GO:0009109)4.04384712
40homocysteine metabolic process (GO:0050667)4.04054887
41imidazole-containing compound metabolic process (GO:0052803)4.01171266
42plasma lipoprotein particle remodeling (GO:0034369)3.98884488
43protein-lipid complex remodeling (GO:0034368)3.98884488
44macromolecular complex remodeling (GO:0034367)3.98884488
45reverse cholesterol transport (GO:0043691)3.97325981
46cellular amino acid catabolic process (GO:0009063)3.94747957
47regulation of plasminogen activation (GO:0010755)3.92309889
48vitamin catabolic process (GO:0009111)3.90643204
49fat-soluble vitamin catabolic process (GO:0042363)3.90643204
50regulation of triglyceride catabolic process (GO:0010896)3.87310019
51NAD metabolic process (GO:0019674)3.86556254
52peptidyl-glutamic acid carboxylation (GO:0017187)3.82909124
53protein carboxylation (GO:0018214)3.82909124
54NADH metabolic process (GO:0006734)3.79318455
55aldehyde catabolic process (GO:0046185)3.78595030
56serine family amino acid metabolic process (GO:0009069)3.76062150
57regulation of complement activation (GO:0030449)3.75850387
58dicarboxylic acid biosynthetic process (GO:0043650)3.75517525
59triglyceride homeostasis (GO:0070328)3.75453578
60acylglycerol homeostasis (GO:0055090)3.75453578
61aspartate family amino acid catabolic process (GO:0009068)3.74908149
62phenylpropanoid metabolic process (GO:0009698)3.74721685
63NAD biosynthetic process (GO:0009435)3.74181786
64glutamate metabolic process (GO:0006536)3.70719787
65phospholipid efflux (GO:0033700)3.69436314
66complement activation, alternative pathway (GO:0006957)3.68941927
67alkaloid metabolic process (GO:0009820)3.67710607
68amine catabolic process (GO:0009310)3.67022021
69cellular biogenic amine catabolic process (GO:0042402)3.67022021
70tolerance induction (GO:0002507)3.66741704
71nicotinamide nucleotide biosynthetic process (GO:0019359)3.64325887
72pyridine nucleotide biosynthetic process (GO:0019363)3.64325887
73ethanol oxidation (GO:0006069)3.60938693
74arginine metabolic process (GO:0006525)3.60711554
75cofactor catabolic process (GO:0051187)3.58598481
76negative regulation of sterol transport (GO:0032372)3.58457036
77negative regulation of cholesterol transport (GO:0032375)3.58457036
78benzene-containing compound metabolic process (GO:0042537)3.58236975
79organic acid catabolic process (GO:0016054)3.57588306
80carboxylic acid catabolic process (GO:0046395)3.57588306
81short-chain fatty acid metabolic process (GO:0046459)3.57378236
82carnitine metabolic process (GO:0009437)3.57091244
83negative T cell selection (GO:0043383)3.56993213
84negative thymic T cell selection (GO:0045060)3.54851233
85succinate metabolic process (GO:0006105)3.54343923
86serine family amino acid biosynthetic process (GO:0009070)3.53883951
87cellular modified amino acid catabolic process (GO:0042219)3.53066639
88indolalkylamine metabolic process (GO:0006586)3.52186580
89bile acid and bile salt transport (GO:0015721)3.51515892
90tyrosine metabolic process (GO:0006570)3.50479862
91ketone body metabolic process (GO:1902224)3.50335357
92valine metabolic process (GO:0006573)3.48746635
93fatty acid beta-oxidation (GO:0006635)3.47138362
94tricarboxylic acid cycle (GO:0006099)3.42587420
95protein-cofactor linkage (GO:0018065)3.41953607
96low-density lipoprotein particle remodeling (GO:0034374)3.41435447
97oxidative phosphorylation (GO:0006119)3.41145348
98vitamin D metabolic process (GO:0042359)3.40367256
99blood coagulation, intrinsic pathway (GO:0007597)3.40027938
100monocarboxylic acid catabolic process (GO:0072329)3.39717707
101drug metabolic process (GO:0017144)3.35566955
102branched-chain amino acid catabolic process (GO:0009083)3.34591241
103omega-hydroxylase P450 pathway (GO:0097267)3.33807980
104positive regulation of gamma-delta T cell activation (GO:0046645)3.32669182
105fatty acid catabolic process (GO:0009062)3.32604395
106acetyl-CoA metabolic process (GO:0006084)3.32374930
107fatty acid oxidation (GO:0019395)3.28719807
108positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.26091510
109mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.26071387
110mitochondrial respiratory chain complex I assembly (GO:0032981)3.26071387
111NADH dehydrogenase complex assembly (GO:0010257)3.26071387
112drug catabolic process (GO:0042737)3.25107525
113urate metabolic process (GO:0046415)3.24493068
114pyrimidine nucleoside catabolic process (GO:0046135)3.22733613
115cellular glucuronidation (GO:0052695)3.22575477
116positive regulation of lipoprotein lipase activity (GO:0051006)3.21628543
117positive regulation of triglyceride lipase activity (GO:0061365)3.21628543
118lipid oxidation (GO:0034440)3.21624483
119negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.20327264
120RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.19740713
121tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.19740713
122dicarboxylic acid metabolic process (GO:0043648)3.18909032
123protein complex biogenesis (GO:0070271)3.18613285
124oxidative demethylation (GO:0070989)3.18062407
125cellular anion homeostasis (GO:0030002)3.17266113
126fat-soluble vitamin biosynthetic process (GO:0042362)3.15422729
127steroid catabolic process (GO:0006706)3.12950600
128branched-chain amino acid metabolic process (GO:0009081)3.10616156
129trivalent inorganic anion homeostasis (GO:0072506)3.05592925
130phosphate ion homeostasis (GO:0055062)3.05592925
131regulation of interleukin-12 biosynthetic process (GO:0045075)3.01569793
132S-adenosylmethionine metabolic process (GO:0046500)2.94431727
133folic acid transport (GO:0015884)2.93144110
134heme transport (GO:0015886)2.88849657
135negative regulation of cell killing (GO:0031342)2.87634685
136negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.87634685
137mitochondrial respiratory chain complex assembly (GO:0033108)2.84300722
138primary alcohol catabolic process (GO:0034310)2.81979321
139regulation of humoral immune response (GO:0002920)2.81688586
140regulation of lipoprotein particle clearance (GO:0010984)2.79658860
141fibrinolysis (GO:0042730)2.79077844
142cellular response to interleukin-15 (GO:0071350)2.78606924
143ethanol metabolic process (GO:0006067)2.78420025
144drug transport (GO:0015893)2.77936925
145negative regulation of DNA-templated transcription, elongation (GO:0032785)2.76303519
146regulation of B cell receptor signaling pathway (GO:0050855)2.70691530
147regulation of gamma-delta T cell differentiation (GO:0045586)2.70451482
148cholesterol efflux (GO:0033344)2.68781965
149amino acid salvage (GO:0043102)2.67987555
150L-methionine salvage (GO:0071267)2.67987555
151L-methionine biosynthetic process (GO:0071265)2.67987555
152response to nitrosative stress (GO:0051409)2.67010931

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.19231228
2RXR_22158963_ChIP-Seq_LIVER_Mouse6.14934662
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.47251734
4EGR1_23403033_ChIP-Seq_LIVER_Mouse5.05935065
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.75685383
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.47065796
7LXR_22158963_ChIP-Seq_LIVER_Mouse4.21162918
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.17720828
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.67425616
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.46991040
11STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.95599525
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.74842128
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.61340489
14NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.57761115
15STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.38775712
16* ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.26855080
17CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.21503854
18TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.16469155
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.16265195
20GATA1_22025678_ChIP-Seq_K562_Human2.09921650
21* SRF_21415370_ChIP-Seq_HL-1_Mouse1.92069264
22* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.91595342
23SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.89581419
24THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.88760617
25IRF8_22096565_ChIP-ChIP_GC-B_Human1.85283025
26KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.78814467
27PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.78176713
28MYC_18555785_ChIP-Seq_MESCs_Mouse1.74183489
29MYC_18358816_ChIP-ChIP_MESCs_Mouse1.69712085
30CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.69091472
31ELF1_17652178_ChIP-ChIP_JURKAT_Human1.66396713
32* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.64797110
33IRF8_21731497_ChIP-ChIP_J774_Mouse1.64714283
34RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.61227734
35EST1_17652178_ChIP-ChIP_JURKAT_Human1.59267508
36ETS1_20019798_ChIP-Seq_JURKAT_Human1.59104323
37MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.54831697
38TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.54604794
39UTX_26944678_Chip-Seq_JUKART_Human1.53074302
40RUNX_20019798_ChIP-Seq_JUKART_Human1.53012722
41MYB_26560356_Chip-Seq_TH2_Human1.52969353
42P300_27268052_Chip-Seq_Bcells_Human1.47798585
43GATA3_26560356_Chip-Seq_TH2_Human1.46165549
44GABP_17652178_ChIP-ChIP_JURKAT_Human1.45627784
45CREB1_15753290_ChIP-ChIP_HEK293T_Human1.45326279
46STAT3_1855785_ChIP-Seq_MESCs_Mouse1.42702439
47* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.40218295
48* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.39852089
49MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.37612862
50SPI1_23547873_ChIP-Seq_NB4_Human1.37349033
51GATA3_27048872_Chip-Seq_THYMUS_Human1.37204509
52SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.36572934
53MAF_26560356_Chip-Seq_TH2_Human1.35954281
54IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.35930071
55IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.30109530
56HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.29910700
57SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.27953033
58RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.27746438
59ELF1_20517297_ChIP-Seq_JURKAT_Human1.26119967
60HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.24781129
61CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.23988682
62* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.23252656
63PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.22559938
64AR_20517297_ChIP-Seq_VCAP_Human1.22457703
65FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.21915747
66* E2F1_20622854_ChIP-Seq_HELA_Human1.21068568
67ZNF274_21170338_ChIP-Seq_K562_Hela1.20675032
68THAP11_20581084_ChIP-Seq_MESCs_Mouse1.20279725
69VDR_21846776_ChIP-Seq_THP-1_Human1.19587182
70NANOG_20526341_ChIP-Seq_ESCs_Human1.19441068
71* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.18042127
72LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.17529691
73YY1_22570637_ChIP-Seq_MALME-3M_Human1.17109330
74MYB_26560356_Chip-Seq_TH1_Human1.14948674
75BP1_19119308_ChIP-ChIP_Hs578T_Human1.10829702
76HTT_18923047_ChIP-ChIP_STHdh_Human1.10671358
77STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.10013913
78P68_20966046_ChIP-Seq_HELA_Human1.09509058
79ESR1_15608294_ChIP-ChIP_MCF-7_Human1.09470790
80CTCF_20526341_ChIP-Seq_ESCs_Human1.09204152
81BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.08843129
82MYC_19030024_ChIP-ChIP_MESCs_Mouse1.07698927
83CIITA_25753668_ChIP-Seq_RAJI_Human1.06595554
84YY1_21170310_ChIP-Seq_MESCs_Mouse1.06070265
85POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.05989658
86TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05413210
87P53_21459846_ChIP-Seq_SAOS-2_Human1.04612965
88RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.04260683
89NOTCH1_21737748_ChIP-Seq_TLL_Human1.03572993
90E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.02816439
91FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01189568
92STAT4_19710469_ChIP-ChIP_TH1__Mouse1.00064979
93TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.00053719
94CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.00025867
95BCL6_27268052_Chip-Seq_Bcells_Human0.99887660
96FOXP3_21729870_ChIP-Seq_TREG_Human0.99762114
97MYC_19829295_ChIP-Seq_ESCs_Human0.99560554
98ERG_20517297_ChIP-Seq_VCAP_Human0.99517050
99MAF_26560356_Chip-Seq_TH1_Human0.99340433
100PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.99038551
101TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.98860547
102* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.98798509
103ETV2_25802403_ChIP-Seq_MESCs_Mouse0.98758617
104TET1_21451524_ChIP-Seq_MESCs_Mouse0.97929487
105SOX2_21211035_ChIP-Seq_LN229_Human0.97857225
106SCL_19346495_ChIP-Seq_HPC-7_Human0.96745537
107PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96594569
108GABP_19822575_ChIP-Seq_HepG2_Human0.95556174
109PHF8_20622854_ChIP-Seq_HELA_Human0.95501375
110NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.95329257
111SPI1_20517297_ChIP-Seq_HL60_Human0.95064179
112DCP1A_22483619_ChIP-Seq_HELA_Human0.94992088
113PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.94286494
114CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94245739
115SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.94109759
116CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94099284
117CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93783086
118VDR_23849224_ChIP-Seq_CD4+_Human0.93478638
119* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.92030433
120* HOXB4_20404135_ChIP-ChIP_EML_Mouse0.91081201
121RARA_24833708_ChIP-Seq_LIVER_Mouse0.90157482
122ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.89977690
123BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.89042576
124* XRN2_22483619_ChIP-Seq_HELA_Human0.88357787
125ZNF263_19887448_ChIP-Seq_K562_Human0.88304342
126SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.88271946
127SRY_22984422_ChIP-ChIP_TESTIS_Rat0.87729053
128LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.85864704
129GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.84968858
130* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.84900264
131HNF4A_19822575_ChIP-Seq_HepG2_Human0.83705479
132IRF1_19129219_ChIP-ChIP_H3396_Human0.80631602
133* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.80450483
134GATA1_19941827_ChIP-Seq_MEL_Mouse0.79901690
135GATA1_22383799_ChIP-Seq_G1ME_Mouse0.78602105
136PU.1_20513432_ChIP-Seq_Bcells_Mouse0.77921545
137TAF2_19829295_ChIP-Seq_ESCs_Human0.77388292
138CTCF_18555785_ChIP-Seq_MESCs_Mouse0.77156951
139NANOG_18555785_ChIP-Seq_MESCs_Mouse0.77045291
140PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.76665284
141SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.75488811
142SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.74696752
143* LXR_22292898_ChIP-Seq_THP-1_Human0.72922250
144EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.72624367
145NELFA_20434984_ChIP-Seq_ESCs_Mouse0.72543892
146RARG_19884340_ChIP-ChIP_MEFs_Mouse0.72316531
147GATA2_22383799_ChIP-Seq_G1ME_Mouse0.70794713
148PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.70436898
149MYC_19079543_ChIP-ChIP_MESCs_Mouse0.69645037
150RARB_24833708_ChIP-Seq_LIVER_Mouse0.69620419
151BCOR_27268052_Chip-Seq_Bcells_Human0.69353422
152* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.68792694
153MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.68723920
154ZFX_18555785_ChIP-Seq_MESCs_Mouse0.68680377
155OCT4_18692474_ChIP-Seq_MEFs_Mouse0.67594874
156CTCF_26484167_Chip-Seq_Bcells_Mouse0.67354794

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.82164195
2MP0005360_urolithiasis6.17572538
3MP0005085_abnormal_gallbladder_physiolo5.63631644
4MP0005365_abnormal_bile_salt5.60401827
5MP0008875_abnormal_xenobiotic_pharmacok4.95438189
6MP0003806_abnormal_nucleotide_metabolis4.49470772
7MP0010329_abnormal_lipoprotein_level3.19158144
8MP0003195_calcinosis2.90990971
9MP0003252_abnormal_bile_duct2.85464280
10MP0009840_abnormal_foam_cell2.82782955
11MP0005332_abnormal_amino_acid2.69928082
12MP0005083_abnormal_biliary_tract2.55750391
13MP0001666_abnormal_nutrient_absorption2.34886135
14MP0006036_abnormal_mitochondrial_physio2.19853895
15MP0009697_abnormal_copulation2.14652709
16MP0003191_abnormal_cellular_cholesterol2.07498057
17MP0003646_muscle_fatigue2.04569147
18* MP0001764_abnormal_homeostasis1.99019133
19MP0004019_abnormal_vitamin_homeostasis1.95620773
20MP0005319_abnormal_enzyme/_coenzyme1.95334509
21MP0003186_abnormal_redox_activity1.93375770
22MP0001986_abnormal_taste_sensitivity1.92154538
23MP0000609_abnormal_liver_physiology1.89400365
24MP0002837_dystrophic_cardiac_calcinosis1.89138154
25MP0005584_abnormal_enzyme/coenzyme_acti1.79774797
26MP0002118_abnormal_lipid_homeostasis1.75033167
27MP0002723_abnormal_immune_serum1.67551535
28MP0004043_abnormal_pH_regulation1.67346172
29MP0006035_abnormal_mitochondrial_morpho1.56156335
30MP0005000_abnormal_immune_tolerance1.53280189
31MP0002138_abnormal_hepatobiliary_system1.51105322
32MP0003868_abnormal_feces_composition1.51098811
33MP0009333_abnormal_splenocyte_physiolog1.47027012
34MP0005646_abnormal_pituitary_gland1.46764758
35MP0002653_abnormal_ependyma_morphology1.43158380
36MP0002420_abnormal_adaptive_immunity1.38530226
37MP0009643_abnormal_urine_homeostasis1.36897443
38MP0001819_abnormal_immune_cell1.36885854
39MP0002419_abnormal_innate_immunity1.35969868
40MP0005084_abnormal_gallbladder_morpholo1.34613842
41MP0003656_abnormal_erythrocyte_physiolo1.34110948
42MP0002148_abnormal_hypersensitivity_rea1.33195430
43MP0002452_abnormal_antigen_presenting1.30659932
44MP0001790_abnormal_immune_system1.30530388
45MP0005387_immune_system_phenotype1.30530388
46MP0002876_abnormal_thyroid_physiology1.26960948
47MP0003724_increased_susceptibility_to1.25748287
48MP0002822_catalepsy1.24246642
49MP0000716_abnormal_immune_system1.22511275
50MP0002736_abnormal_nociception_after1.22261672
51MP0000372_irregular_coat_pigmentation1.19774385
52MP0005266_abnormal_metabolism1.18031764
53MP0002722_abnormal_immune_system1.15073192
54MP0000598_abnormal_liver_morphology1.14332880
55MP0002254_reproductive_system_inflammat1.14300493
56MP0008877_abnormal_DNA_methylation1.14264043
57MP0002398_abnormal_bone_marrow1.13717369
58MP0003866_abnormal_defecation1.10856747
59MP0001661_extended_life_span1.09400466
60MP0000703_abnormal_thymus_morphology1.09000500
61MP0002234_abnormal_pharynx_morphology1.07826344
62MP0008469_abnormal_protein_level1.07732290
63MP0001853_heart_inflammation1.06330065
64MP0005636_abnormal_mineral_homeostasis1.06038875
65MP0010155_abnormal_intestine_physiology1.04619252
66* MP0005376_homeostasis/metabolism_phenot1.04449845
67MP0003011_delayed_dark_adaptation1.04114113
68MP0000749_muscle_degeneration1.03215311
69MP0005330_cardiomyopathy1.02130662
70MP0005389_reproductive_system_phenotype0.99121614
71MP0008872_abnormal_physiological_respon0.97324487
72MP0003172_abnormal_lysosome_physiology0.96041736
73MP0009764_decreased_sensitivity_to0.95588896
74MP0005451_abnormal_body_composition0.95328615
75MP0002405_respiratory_system_inflammati0.94621713
76MP0004147_increased_porphyrin_level0.92754416
77MP0002429_abnormal_blood_cell0.92500685
78MP0009642_abnormal_blood_homeostasis0.92035226
79MP0001533_abnormal_skeleton_physiology0.91212543
80MP0002269_muscular_atrophy0.90936974
81MP0009763_increased_sensitivity_to0.89895474
82MP0010368_abnormal_lymphatic_system0.88490082
83MP0004130_abnormal_muscle_cell0.84359652
84MP0004036_abnormal_muscle_relaxation0.83960350
85MP0005551_abnormal_eye_electrophysiolog0.83344646
86MP0009785_altered_susceptibility_to0.82383866
87MP0006054_spinal_hemorrhage0.81543944
88MP0004084_abnormal_cardiac_muscle0.81389917
89MP0001835_abnormal_antigen_presentation0.79934036
90MP0003638_abnormal_response/metabolism_0.79272301
91MP0001542_abnormal_bone_strength0.78820348
92MP0004215_abnormal_myocardial_fiber0.78118067
93MP0005464_abnormal_platelet_physiology0.77026105
94MP0002078_abnormal_glucose_homeostasis0.76887088
95MP0005535_abnormal_body_temperature0.76875943
96MP0008995_early_reproductive_senescence0.73934466
97MP0002160_abnormal_reproductive_system0.73489669
98MP0005670_abnormal_white_adipose0.72498387
99MP0000604_amyloidosis0.72377815
100MP0005645_abnormal_hypothalamus_physiol0.71675786
101MP0002089_abnormal_postnatal_growth/wei0.71382519
102MP0005671_abnormal_response_to0.70776196
103MP0004142_abnormal_muscle_tone0.70768747
104MP0002095_abnormal_skin_pigmentation0.70236633
105MP0005167_abnormal_blood-brain_barrier0.69583261
106MP0002132_abnormal_respiratory_system0.68013494
107MP0005647_abnormal_sex_gland0.67983795
108MP0004133_heterotaxia0.67839821
109MP0001968_abnormal_touch/_nociception0.67799089
110MP0001919_abnormal_reproductive_system0.67715630
111MP0000685_abnormal_immune_system0.66090511
112MP0005075_abnormal_melanosome_morpholog0.65173633
113MP0009765_abnormal_xenobiotic_induced0.64747111
114MP0008874_decreased_physiological_sensi0.63575744
115MP0005385_cardiovascular_system_phenoty0.62732869
116MP0001544_abnormal_cardiovascular_syste0.62732869
117MP0002332_abnormal_exercise_endurance0.61937589
118MP0000230_abnormal_systemic_arterial0.61099049
119MP0002127_abnormal_cardiovascular_syste0.59671021
120MP0001756_abnormal_urination0.58909608
121MP0003879_abnormal_hair_cell0.58244649
122MP0003436_decreased_susceptibility_to0.57117017
123MP0003718_maternal_effect0.55294695
124MP0005165_increased_susceptibility_to0.54718060
125MP0005334_abnormal_fat_pad0.53527457
126MP0000751_myopathy0.53314203
127MP0005397_hematopoietic_system_phenotyp0.52110180
128MP0001545_abnormal_hematopoietic_system0.52110180
129MP0005448_abnormal_energy_balance0.51398081
130MP0001845_abnormal_inflammatory_respons0.51327710
131MP0008873_increased_physiological_sensi0.50746958
132MP0000689_abnormal_spleen_morphology0.49694569
133MP0002971_abnormal_brown_adipose0.48992057
134MP0002136_abnormal_kidney_physiology0.48769899
135MP0003763_abnormal_thymus_physiology0.48008040
136MP0005025_abnormal_response_to0.47123113
137MP0003075_altered_response_to0.46082639
138MP0003221_abnormal_cardiomyocyte_apopto0.46071114
139MP0002396_abnormal_hematopoietic_system0.44321017
140MP0006138_congestive_heart_failure0.44266957
141MP0000639_abnormal_adrenal_gland0.43666857
142MP0001800_abnormal_humoral_immune0.41811129
143MP0005166_decreased_susceptibility_to0.40733111

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)5.72263413
2Intrahepatic cholestasis (HP:0001406)5.26102033
3Abnormality of monocarboxylic acid metabolism (HP:0010996)5.17980790
4Hypobetalipoproteinemia (HP:0003563)5.00412182
5Deep venous thrombosis (HP:0002625)4.70481717
6Prolonged partial thromboplastin time (HP:0003645)4.59236689
7Hyperammonemia (HP:0001987)4.54814575
8Xanthomatosis (HP:0000991)4.50104406
9Abnormal number of erythroid precursors (HP:0012131)4.23127520
10Hyperlipoproteinemia (HP:0010980)4.21341571
11Hyperglycinemia (HP:0002154)4.15891795
12Ketosis (HP:0001946)4.04878752
13Abnormality of fatty-acid metabolism (HP:0004359)3.77605498
14Hyperglycinuria (HP:0003108)3.70322932
15Elevated erythrocyte sedimentation rate (HP:0003565)3.66893652
16Osteomalacia (HP:0002749)3.65079849
17Hypolipoproteinemia (HP:0010981)3.63606370
18Cerebral edema (HP:0002181)3.60868634
19Abnormality of serine family amino acid metabolism (HP:0010894)3.56692273
20Abnormality of glycine metabolism (HP:0010895)3.56692273
21Hypoglycemic coma (HP:0001325)3.56035639
22Dicarboxylic aciduria (HP:0003215)3.54494758
23Abnormality of dicarboxylic acid metabolism (HP:0010995)3.54494758
24Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.46800316
25Abnormality of cells of the erythroid lineage (HP:0012130)3.45787334
26Abnormality of pyrimidine metabolism (HP:0004353)3.43488816
27Hepatic necrosis (HP:0002605)3.43076728
28Systemic lupus erythematosus (HP:0002725)3.37644331
29Joint hemorrhage (HP:0005261)3.36747075
30Vascular calcification (HP:0004934)3.35760000
31Stomatitis (HP:0010280)3.34799974
32Hyperbilirubinemia (HP:0002904)3.30868042
33Abnormality of glutamine family amino acid metabolism (HP:0010902)3.29038046
34Lethargy (HP:0001254)3.28813704
35Delayed CNS myelination (HP:0002188)3.27272236
36Abnormality of aspartate family amino acid metabolism (HP:0010899)3.25058834
37Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.23759673
38Abnormality of methionine metabolism (HP:0010901)3.22219013
39Complement deficiency (HP:0004431)3.17417829
40Ketoacidosis (HP:0001993)3.12392686
41Abnormality of serum amino acid levels (HP:0003112)3.08934190
42Acute encephalopathy (HP:0006846)3.07676711
43Fat malabsorption (HP:0002630)3.06049076
44Abnormality of sulfur amino acid metabolism (HP:0004339)3.04582916
45* Metabolic acidosis (HP:0001942)3.03624422
46Hyperalaninemia (HP:0003348)3.02253961
47Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.02253961
48Abnormality of alanine metabolism (HP:0010916)3.02253961
49Hypoalphalipoproteinemia (HP:0003233)3.02012026
50Generalized aminoaciduria (HP:0002909)3.01925668
51Abnormality of the common coagulation pathway (HP:0010990)2.97003875
52Hepatocellular necrosis (HP:0001404)2.92723122
53Gout (HP:0001997)2.89169453
54Conjugated hyperbilirubinemia (HP:0002908)2.88257360
55Abnormal mitochondria in muscle tissue (HP:0008316)2.81359075
56Abnormality of the intrinsic pathway (HP:0010989)2.80480918
57Abnormal biliary tract physiology (HP:0012439)2.80437382
58Bile duct proliferation (HP:0001408)2.80437382
59Lactic acidosis (HP:0003128)2.76968805
60Epidermoid cyst (HP:0200040)2.75561602
61Cardiovascular calcification (HP:0011915)2.74555106
62Acute necrotizing encephalopathy (HP:0006965)2.70998169
63Ragged-red muscle fibers (HP:0003200)2.68312834
64Abnormality of nucleobase metabolism (HP:0010932)2.65208605
65Abnormal enzyme/coenzyme activity (HP:0012379)2.62699542
66Gingival bleeding (HP:0000225)2.58124394
67Increased CSF lactate (HP:0002490)2.56572590
68Hypercholesterolemia (HP:0003124)2.56372931
69Reduced antithrombin III activity (HP:0001976)2.55262963
70Nausea (HP:0002018)2.54469996
71Elevated alkaline phosphatase (HP:0003155)2.54383209
72Abnormality of alkaline phosphatase activity (HP:0004379)2.52197918
73* Vomiting (HP:0002013)2.51879380
74Pustule (HP:0200039)2.51371316
75Mitochondrial inheritance (HP:0001427)2.49252899
76Decreased activity of mitochondrial respiratory chain (HP:0008972)2.49112397
77Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.49112397
78Panhypogammaglobulinemia (HP:0003139)2.47202534
79Spontaneous abortion (HP:0005268)2.46142008
80Myoglobinuria (HP:0002913)2.44243500
81Abnormal urine phosphate concentration (HP:0012599)2.42603217
82Steatorrhea (HP:0002570)2.42427868
83Recurrent gram-negative bacterial infections (HP:0005420)2.39979650
84Cholelithiasis (HP:0001081)2.38264464
85Increased muscle lipid content (HP:0009058)2.35772695
86Neonatal onset (HP:0003623)2.35753466
87Palpitations (HP:0001962)2.34601697
88Myositis (HP:0100614)2.34503274
89Increased serum lactate (HP:0002151)2.29611718
90Rhabdomyolysis (HP:0003201)2.28828126
91Abnormality of complement system (HP:0005339)2.28243062
92Abnormality of renal resorption (HP:0011038)2.27641313
93Pulmonary embolism (HP:0002204)2.27172895
94Abnormal gallbladder morphology (HP:0012437)2.26436316
95Abnormality of purine metabolism (HP:0004352)2.26068499
96Anorexia (HP:0002039)2.25678143
97Proximal tubulopathy (HP:0000114)2.24856039
98Severe combined immunodeficiency (HP:0004430)2.24491909
99Late onset (HP:0003584)2.24107934
100Chronic otitis media (HP:0000389)2.22143925
101Methylmalonic aciduria (HP:0012120)2.16465317
102Type I transferrin isoform profile (HP:0003642)2.14567190
103Increased intramyocellular lipid droplets (HP:0012240)2.14354077
104Cholecystitis (HP:0001082)2.13735801
105Abnormal gallbladder physiology (HP:0012438)2.13735801
106Abnormality of glycolysis (HP:0004366)2.07762895
107Increased serum pyruvate (HP:0003542)2.07762895
108Acute hepatic failure (HP:0006554)2.06733495
109Recurrent fungal infections (HP:0002841)2.06377496
110Abnormality of urine glucose concentration (HP:0011016)2.05603585
111Glycosuria (HP:0003076)2.05603585
112IgG deficiency (HP:0004315)2.04754178
113Progressive macrocephaly (HP:0004481)2.04293878
1143-Methylglutaconic aciduria (HP:0003535)2.02538867
115Cerebral palsy (HP:0100021)2.01713881
116Agammaglobulinemia (HP:0004432)2.01692093
117Rickets (HP:0002748)2.00922911
118CNS demyelination (HP:0007305)1.98786667
119Epistaxis (HP:0000421)1.98448773
120Decreased electroretinogram (ERG) amplitude (HP:0000654)1.98080335
121Spastic diplegia (HP:0001264)1.96944740
122Sensorimotor neuropathy (HP:0007141)1.96472199
123Hepatocellular carcinoma (HP:0001402)1.96449628
124Renal cortical cysts (HP:0000803)1.96073861
125Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.95897451
126Opisthotonus (HP:0002179)1.95738586
127Brushfield spots (HP:0001088)1.95519566
128Acanthocytosis (HP:0001927)1.94886236
129Elevated hepatic transaminases (HP:0002910)1.91121621
130Hypophosphatemia (HP:0002148)1.88341339
131Status epilepticus (HP:0002133)1.88218795
132Joint swelling (HP:0001386)1.87917224
133Pancreatitis (HP:0001733)1.87759923
134Thrombophlebitis (HP:0004418)1.87113219
135Abnormality of the prostate (HP:0008775)1.87022585
136Seborrheic dermatitis (HP:0001051)1.86868333
137Malnutrition (HP:0004395)1.86139205
138Type 2 muscle fiber atrophy (HP:0003554)1.85269007
139Optic disc pallor (HP:0000543)1.85025212
140Abnormal delayed hypersensitivity skin test (HP:0002963)1.84172198
141Nonprogressive disorder (HP:0003680)1.83927896
142Gastrointestinal infarctions (HP:0005244)1.82893849
143Irritability (HP:0000737)1.82723659
144Hypochromic microcytic anemia (HP:0004840)1.82667889
145Abnormality of the heme biosynthetic pathway (HP:0010472)1.82537268
146Abnormality of T cells (HP:0002843)1.80603436
147Emotional lability (HP:0000712)1.79857317
148Glomerulonephritis (HP:0000099)1.78907731
149Petechiae (HP:0000967)1.78353921
150Purpura (HP:0000979)1.78180290
151Constricted visual fields (HP:0001133)1.76311177
152Recurrent bacterial skin infections (HP:0005406)1.72526630

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.39737685
2PASK3.45325053
3MAP3K123.41621938
4MYLK2.69459688
5ERN12.65699477
6TESK22.58034171
7KDR2.57098961
8DAPK12.48233013
9MAP4K22.47759322
10TAOK32.42255175
11DAPK22.21357807
12CASK2.19354699
13NEK12.11262397
14FLT32.10911503
15TLK12.08462794
16MAP4K12.07216199
17CDK192.04408770
18MAP3K112.02900390
19MUSK1.98639861
20FGFR41.94320091
21ACVR1B1.89660605
22OBSCN1.77311997
23CCNB11.75116965
24NME21.66086668
25PDK31.65538634
26PDK41.65538634
27ITK1.62177062
28NME11.55349775
29MAP2K41.48301798
30RIPK41.46732706
31TXK1.45342871
32MAPKAPK31.45140182
33TYK21.44800615
34TIE11.44502223
35PINK11.41198549
36TGFBR11.39583628
37STK161.39397528
38CAMKK11.38346568
39EIF2AK11.34878809
40AKT31.32570334
41SIK21.31552419
42TBK11.31089429
43NUAK11.28994305
44MAP2K31.27679255
45MAP2K61.27082260
46FES1.26117868
47SIK31.26038067
48MAPK111.25354218
49MAPK121.19273431
50GRK11.16764104
51TAOK21.15980387
52LCK1.15125346
53PRKCQ1.11927447
54NTRK21.08443735
55PIK3CA1.04932693
56PIM21.04396827
57VRK21.03727265
58PKN21.03667120
59ZAP701.01364005
60SIK11.00800177
61DAPK30.99705442
62EIF2AK30.99319835
63MAPK40.98304383
64GRK70.97828849
65PDK20.97505720
66BTK0.97024062
67BUB10.96626026
68FRK0.94484032
69MAP3K70.94286104
70GRK60.93851133
71MAP3K140.93530010
72MAP2K70.92622207
73MAP3K130.91991433
74KIT0.91496925
75IKBKE0.89141135
76CAMKK20.86329380
77SGK2230.83291893
78SGK4940.83291893
79MARK30.82128795
80TSSK60.79750795
81CDK90.79246230
82FGR0.76452829
83ADRBK10.75028901
84PIK3CG0.74779383
85TEC0.73015883
86DYRK20.72697848
87SYK0.72609540
88TGFBR20.71249045
89CAMK10.70281865
90STK240.67172402
91MST40.64834082
92MAP3K30.64064725
93CAMK40.64006309
94EPHA40.63893759
95MAPK70.63773061
96VRK10.63695201
97MATK0.63690430
98CDK80.62523437
99MAP3K50.62239861
100JAK10.62038036
101MAPK130.61759230
102ADRBK20.59905343
103PRKD20.59567269
104BMPR1B0.59151746
105ABL20.59054413
106HCK0.55719237
107PIM10.55468988
108TNK20.53493896
109STK110.53061714
110INSRR0.52273654
111JAK20.51735960
112CSF1R0.51041538
113GRK50.50897211
114WEE10.50884298
115NLK0.50077726
116NEK90.47763278
117SGK20.44409428
118IRAK40.42540964
119CSK0.42187731
120MAP3K40.42171806
121BLK0.41844315
122MAPKAPK50.41314425
123ERBB40.40942899
124FGFR20.39564928
125PRKCZ0.38757703
126PRKCG0.38538814
127BMPR20.38188686
128IRAK30.38080192
129IGF1R0.37705572
130EPHA30.37553091
131MAPK150.37495048
132PRKAA20.37017770
133LYN0.36955601
134CAMK2G0.36151242
135CSNK1A10.34948777
136IKBKB0.33710766
137ZAK0.33496263
138CHUK0.33477836
139CSNK2A10.32405085
140PRKACA0.31256119
141FYN0.31159264
142MAP2K20.30981358
143PRKACG0.30976191
144JAK30.30374030
145MAP3K10.30076393
146MST1R0.29042701
147AKT20.28163324
148PDK10.27833049
149RPS6KB20.26665097
150PRKCD0.25345939

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004004.07916236
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.89819409
3Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.95569897
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.85246443
5Arginine biosynthesis_Homo sapiens_hsa002202.83662222
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.78102613
7Caffeine metabolism_Homo sapiens_hsa002322.65371354
8Fatty acid degradation_Homo sapiens_hsa000712.54612460
9Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.44381677
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.34215420
11Tryptophan metabolism_Homo sapiens_hsa003802.27215172
12Nitrogen metabolism_Homo sapiens_hsa009102.26274696
13Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.21074233
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.19470860
15Propanoate metabolism_Homo sapiens_hsa006402.19311372
16Peroxisome_Homo sapiens_hsa041462.07324440
17Pentose and glucuronate interconversions_Homo sapiens_hsa000402.06980056
18Complement and coagulation cascades_Homo sapiens_hsa046102.01556973
19Drug metabolism - other enzymes_Homo sapiens_hsa009831.99665953
20Pyruvate metabolism_Homo sapiens_hsa006201.87427525
21Linoleic acid metabolism_Homo sapiens_hsa005911.84952998
22Cysteine and methionine metabolism_Homo sapiens_hsa002701.83277254
23Carbon metabolism_Homo sapiens_hsa012001.80473677
24Cyanoamino acid metabolism_Homo sapiens_hsa004601.79752758
25Butanoate metabolism_Homo sapiens_hsa006501.79255028
26Biosynthesis of amino acids_Homo sapiens_hsa012301.72091311
27Chemical carcinogenesis_Homo sapiens_hsa052041.71026956
28Fatty acid metabolism_Homo sapiens_hsa012121.67306521
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.66674972
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.64989732
31Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.64504468
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.61411393
33beta-Alanine metabolism_Homo sapiens_hsa004101.59428166
34Phenylalanine metabolism_Homo sapiens_hsa003601.57074188
35Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.55968148
36PPAR signaling pathway_Homo sapiens_hsa033201.46923858
37Folate biosynthesis_Homo sapiens_hsa007901.38986266
38Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.34273322
39Selenocompound metabolism_Homo sapiens_hsa004501.33560696
40Steroid hormone biosynthesis_Homo sapiens_hsa001401.33516071
41Histidine metabolism_Homo sapiens_hsa003401.29379388
42Other glycan degradation_Homo sapiens_hsa005111.27417718
43Retinol metabolism_Homo sapiens_hsa008301.27114402
44Tyrosine metabolism_Homo sapiens_hsa003501.24544927
45Sulfur relay system_Homo sapiens_hsa041221.23869317
46Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.23750062
47Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.22265213
48Arachidonic acid metabolism_Homo sapiens_hsa005901.21740981
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.17193968
50Fatty acid elongation_Homo sapiens_hsa000621.15332760
51Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.15030645
52Starch and sucrose metabolism_Homo sapiens_hsa005001.14213153
53Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.11008041
54Staphylococcus aureus infection_Homo sapiens_hsa051501.08052028
55Bile secretion_Homo sapiens_hsa049761.07224357
56Oxidative phosphorylation_Homo sapiens_hsa001901.05393341
57Homologous recombination_Homo sapiens_hsa034401.01188362
58Graft-versus-host disease_Homo sapiens_hsa053321.01003072
59Proteasome_Homo sapiens_hsa030500.99304515
60Allograft rejection_Homo sapiens_hsa053300.98114219
61Intestinal immune network for IgA production_Homo sapiens_hsa046720.94730966
62Fructose and mannose metabolism_Homo sapiens_hsa000510.94459174
63Parkinsons disease_Homo sapiens_hsa050120.93849770
64Sulfur metabolism_Homo sapiens_hsa009200.92394641
65Autoimmune thyroid disease_Homo sapiens_hsa053200.92206250
66Pentose phosphate pathway_Homo sapiens_hsa000300.91209727
67One carbon pool by folate_Homo sapiens_hsa006700.90222722
68Arginine and proline metabolism_Homo sapiens_hsa003300.84647114
69Fat digestion and absorption_Homo sapiens_hsa049750.82592439
70Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.82363962
71ABC transporters_Homo sapiens_hsa020100.81647670
72Vitamin digestion and absorption_Homo sapiens_hsa049770.74979721
73NF-kappa B signaling pathway_Homo sapiens_hsa040640.74149369
74Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.70026779
75Glutathione metabolism_Homo sapiens_hsa004800.69918013
76Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.69028697
77Glycosaminoglycan degradation_Homo sapiens_hsa005310.66137059
78* Metabolic pathways_Homo sapiens_hsa011000.65677945
79Type I diabetes mellitus_Homo sapiens_hsa049400.63743694
80Ribosome_Homo sapiens_hsa030100.63625440
81Hematopoietic cell lineage_Homo sapiens_hsa046400.60213638
82Vitamin B6 metabolism_Homo sapiens_hsa007500.53030623
83Pyrimidine metabolism_Homo sapiens_hsa002400.52163094
84* Galactose metabolism_Homo sapiens_hsa000520.50597238
85Rheumatoid arthritis_Homo sapiens_hsa053230.49425674
86Asthma_Homo sapiens_hsa053100.49308912
87Maturity onset diabetes of the young_Homo sapiens_hsa049500.48754949
88Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.48025581
89Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.46313459
90Alzheimers disease_Homo sapiens_hsa050100.45847557
91Huntingtons disease_Homo sapiens_hsa050160.44281094
92Glycerolipid metabolism_Homo sapiens_hsa005610.39678732
93Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.39233113
94Antigen processing and presentation_Homo sapiens_hsa046120.37191792
95Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.36801799
96Lysine degradation_Homo sapiens_hsa003100.36439886
97Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.34539010
98Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.33860935
99Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.29621804
100Cardiac muscle contraction_Homo sapiens_hsa042600.29602383
101* Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.29056720
102Fanconi anemia pathway_Homo sapiens_hsa034600.28151711
103Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.25555441
104T cell receptor signaling pathway_Homo sapiens_hsa046600.24753132
105Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.18833196
106RNA polymerase_Homo sapiens_hsa030200.16803285
107Purine metabolism_Homo sapiens_hsa002300.14369154
108Adipocytokine signaling pathway_Homo sapiens_hsa049200.14127453
109Glucagon signaling pathway_Homo sapiens_hsa049220.11700323
110Insulin resistance_Homo sapiens_hsa049310.11323215
111Primary immunodeficiency_Homo sapiens_hsa053400.10160603
112Regulation of autophagy_Homo sapiens_hsa041400.08438328
113Base excision repair_Homo sapiens_hsa034100.05790104
114Steroid biosynthesis_Homo sapiens_hsa001000.03666516
115DNA replication_Homo sapiens_hsa030300.02900572
116Protein export_Homo sapiens_hsa03060-0.1151205
117alpha-Linolenic acid metabolism_Homo sapiens_hsa00592-0.0986116
118SNARE interactions in vesicular transport_Homo sapiens_hsa04130-0.0971021
119Circadian rhythm_Homo sapiens_hsa04710-0.0552397
120Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014-0.0508222
121Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008-0.0462886
122Fatty acid biosynthesis_Homo sapiens_hsa00061-0.0310874
123Glycerophospholipid metabolism_Homo sapiens_hsa00564-0.0245474
124Collecting duct acid secretion_Homo sapiens_hsa04966-0.0178192
125RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.0078162

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