GAN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the cytoskeletal BTB/kelch (Broad-Complex, Tramtrack and Bric a brac) repeat family. The encoded protein plays a role in neurofilament architecture and is involved in mediating the ubiquitination and degradation of some proteins. Defects in this gene are a cause of giant axonal neuropathy (GAN). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of skin barrier (GO:0061436)9.15181020
2regulation of water loss via skin (GO:0033561)7.74920519
3keratinization (GO:0031424)6.45483990
4desmosome organization (GO:0002934)6.18150047
5negative regulation of translation, ncRNA-mediated (GO:0040033)5.78181501
6regulation of translation, ncRNA-mediated (GO:0045974)5.78181501
7negative regulation of translation involved in gene silencing by miRNA (GO:0035278)5.78181501
8multicellular organismal water homeostasis (GO:0050891)4.94220156
9long-chain fatty acid biosynthetic process (GO:0042759)4.82632607
10microtubule depolymerization (GO:0007019)4.18342135
11keratinocyte proliferation (GO:0043616)4.14391760
12atrial cardiac muscle cell action potential (GO:0086014)4.06560066
13DNA double-strand break processing (GO:0000729)3.92990383
14keratinocyte differentiation (GO:0030216)3.88086667
15water homeostasis (GO:0030104)3.74848707
16hair cycle (GO:0042633)3.74675425
17molting cycle (GO:0042303)3.74675425
18peptide cross-linking (GO:0018149)3.53443293
19replication fork processing (GO:0031297)3.51940464
20hemidesmosome assembly (GO:0031581)3.46593101
21cilium or flagellum-dependent cell motility (GO:0001539)3.34180522
22axonemal dynein complex assembly (GO:0070286)3.25904348
23positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.24930955
24regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.24930955
25cytoplasmic mRNA processing body assembly (GO:0033962)3.23244103
26negative regulation of DNA-dependent DNA replication (GO:2000104)3.20527346
27epidermal cell differentiation (GO:0009913)3.13739414
28regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)3.12072994
29positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO3.12072994
30motile cilium assembly (GO:0044458)3.04262713
31regulation of mesoderm development (GO:2000380)3.01597141
32piRNA metabolic process (GO:0034587)3.00154129
33sphingoid metabolic process (GO:0046519)2.97047353
34positive regulation of glomerulus development (GO:0090193)2.94123132
35L-fucose catabolic process (GO:0042355)2.92921588
36fucose catabolic process (GO:0019317)2.92921588
37L-fucose metabolic process (GO:0042354)2.92921588
38sympathetic nervous system development (GO:0048485)2.89870194
39presynaptic membrane assembly (GO:0097105)2.89775223
40reflex (GO:0060004)2.89638744
41water-soluble vitamin biosynthetic process (GO:0042364)2.87924237
42negative regulation of keratinocyte proliferation (GO:0010839)2.86011110
43regulation of cell proliferation involved in kidney development (GO:1901722)2.84883647
44limb bud formation (GO:0060174)2.83217427
45behavioral response to nicotine (GO:0035095)2.79601713
46epidermis development (GO:0008544)2.79247641
47regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.74643239
48regulation of mitotic spindle checkpoint (GO:1903504)2.74643239
49synapsis (GO:0007129)2.74446815
50protein K11-linked deubiquitination (GO:0035871)2.73432944
51pre-miRNA processing (GO:0031054)2.71869156
52sphingosine metabolic process (GO:0006670)2.68755383
53dorsal/ventral axis specification (GO:0009950)2.68060510
54somatic hypermutation of immunoglobulin genes (GO:0016446)2.67945679
55somatic diversification of immune receptors via somatic mutation (GO:0002566)2.67945679
56regulation of meiosis I (GO:0060631)2.65065665
57chromatin remodeling at centromere (GO:0031055)2.62780766
58negative regulation of transcription regulatory region DNA binding (GO:2000678)2.61889024
59recombinational repair (GO:0000725)2.61103570
60regulation of telomere maintenance (GO:0032204)2.60649795
61platelet dense granule organization (GO:0060155)2.60382637
62regulation of action potential (GO:0098900)2.59844552
63regulation of centriole replication (GO:0046599)2.59081962
64maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.59050607
65response to pheromone (GO:0019236)2.58363226
66double-strand break repair via homologous recombination (GO:0000724)2.58270247
67regulation of transforming growth factor beta1 production (GO:0032908)2.57838780
68acrosome reaction (GO:0007340)2.57098445
69negative regulation of synaptic transmission, GABAergic (GO:0032229)2.56515918
70cerebral cortex radially oriented cell migration (GO:0021799)2.56246441
71detection of bacterium (GO:0016045)2.56125873
72histone exchange (GO:0043486)2.54802336
73intestinal epithelial cell development (GO:0060576)2.54224073
74cellular response to sterol (GO:0036315)2.52640378
75negative regulation of T cell mediated immunity (GO:0002710)2.52385023
76regulation of nuclear cell cycle DNA replication (GO:0033262)2.51093522
77intermediate filament organization (GO:0045109)2.48709866
78keratinocyte development (GO:0003334)2.48532925
79negative regulation of DNA recombination (GO:0045910)2.46725934
80cell migration in hindbrain (GO:0021535)2.46333886
81L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.46307383
82cornea development in camera-type eye (GO:0061303)2.45783574
83detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.45781240
84DNA deamination (GO:0045006)2.45771993
85regulation of DNA endoreduplication (GO:0032875)2.45346775
86indole-containing compound catabolic process (GO:0042436)2.45187929
87indolalkylamine catabolic process (GO:0046218)2.45187929
88tryptophan catabolic process (GO:0006569)2.45187929
89RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.44475816
90diol metabolic process (GO:0034311)2.44350500
91microtubule polymerization or depolymerization (GO:0031109)2.43821996
92somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.43698477
93isotype switching (GO:0045190)2.43698477
94somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.43698477
95positive regulation of interleukin-8 secretion (GO:2000484)2.42329145
96G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.41992507
97neural tube formation (GO:0001841)2.41969519
98presynaptic membrane organization (GO:0097090)2.41626904
99prostate gland growth (GO:0060736)2.40897141
100ectoderm development (GO:0007398)2.40630716
101regulation of hippo signaling (GO:0035330)2.40420862
102mesenchymal-epithelial cell signaling (GO:0060638)2.38737340
103indolalkylamine metabolic process (GO:0006586)2.38113126
104CENP-A containing nucleosome assembly (GO:0034080)2.37958212
105reciprocal DNA recombination (GO:0035825)2.37763354
106reciprocal meiotic recombination (GO:0007131)2.37763354
107DNA replication-dependent nucleosome assembly (GO:0006335)2.37370552
108DNA replication-dependent nucleosome organization (GO:0034723)2.37370552
109kynurenine metabolic process (GO:0070189)2.37133294
110tryptophan metabolic process (GO:0006568)2.35966016
111somite development (GO:0061053)2.35621454
112positive regulation of meiotic cell cycle (GO:0051446)2.34580779
113sulfation (GO:0051923)2.34445679
114nonmotile primary cilium assembly (GO:0035058)2.33271835
115regulation of glomerulus development (GO:0090192)2.32682591
116positive regulation of cardiac muscle cell differentiation (GO:2000727)2.32585875
117protein K6-linked ubiquitination (GO:0085020)2.31915146
118genitalia morphogenesis (GO:0035112)2.31056004
119cell wall macromolecule metabolic process (GO:0044036)2.29539441
120cell wall macromolecule catabolic process (GO:0016998)2.29539441
121resolution of meiotic recombination intermediates (GO:0000712)2.29420034
122photoreceptor cell maintenance (GO:0045494)2.28713728
123exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.28352803
124otic vesicle formation (GO:0030916)2.28005790
125bundle of His cell to Purkinje myocyte communication (GO:0086069)2.27265295
126cilium morphogenesis (GO:0060271)2.27217206
127G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.26406061
128negative regulation of telomere maintenance (GO:0032205)2.25692932
129respiratory chain complex IV assembly (GO:0008535)2.25483193
130positive regulation of embryonic development (GO:0040019)2.25444878
131response to X-ray (GO:0010165)2.25413245
132detection of other organism (GO:0098543)2.25407292
133nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.24577690
134positive regulation of interleukin-1 beta secretion (GO:0050718)2.23900883
135regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.23204290
136anterior/posterior axis specification, embryo (GO:0008595)2.22064785
137magnesium ion transport (GO:0015693)2.21369042
138cardiac right ventricle morphogenesis (GO:0003215)2.21294762
139microtubule anchoring (GO:0034453)2.20659430
140phospholipid scrambling (GO:0017121)2.20226491
141DNA replication checkpoint (GO:0000076)2.20000292
142positive regulation of mRNA catabolic process (GO:0061014)2.19785220
143regulation of helicase activity (GO:0051095)2.18751660
144G-protein coupled receptor internalization (GO:0002031)2.18569328
145regulation of germinal center formation (GO:0002634)2.18219489
146proteasome assembly (GO:0043248)2.18211482
147histone H3-K4 trimethylation (GO:0080182)2.16688074
148glucosamine-containing compound catabolic process (GO:1901072)2.16060012
149regulation of ruffle assembly (GO:1900027)2.16038674
150negative regulation of systemic arterial blood pressure (GO:0003085)2.15943168
151prenylation (GO:0097354)2.15398422
152protein prenylation (GO:0018342)2.15398422
153planar cell polarity pathway involved in neural tube closure (GO:0090179)2.15117407
154regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.14645990
155ganglion development (GO:0061548)2.13539303
156axoneme assembly (GO:0035082)2.13175741
157kidney morphogenesis (GO:0060993)2.12974753
158lateral sprouting from an epithelium (GO:0060601)2.12643396
159C4-dicarboxylate transport (GO:0015740)2.12419735
160positive regulation of Rho protein signal transduction (GO:0035025)2.11599652
161fatty acid elongation (GO:0030497)2.11479314
162embryonic pattern specification (GO:0009880)2.10408835
163negative regulation of mast cell activation (GO:0033004)2.10282390
164telomere maintenance via telomerase (GO:0007004)2.09252192
165maturation of 5.8S rRNA (GO:0000460)2.08961281
166regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.08730827
167myoblast fusion (GO:0007520)2.08722787
168embryonic camera-type eye development (GO:0031076)2.06264458
169import into cell (GO:0098657)2.05585597
170skin morphogenesis (GO:0043589)2.05531259
171DNA methylation involved in gamete generation (GO:0043046)2.05437312
172regulation of somitogenesis (GO:0014807)2.05333296
173positive regulation of interleukin-1 secretion (GO:0050716)2.02382436
174regulation of mRNA 3-end processing (GO:0031440)2.01283745
175retina layer formation (GO:0010842)2.01090783
176dendritic spine morphogenesis (GO:0060997)2.00104632
177startle response (GO:0001964)1.96848596
178regulation of keratinocyte proliferation (GO:0010837)1.96036435
179central nervous system projection neuron axonogenesis (GO:0021952)1.94280105
180positive regulation of mRNA 3-end processing (GO:0031442)1.93907108
181epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)1.93538023
182positive regulation of NIK/NF-kappaB signaling (GO:1901224)1.93155891
183neural crest cell development (GO:0014032)1.91766870
184ventricular system development (GO:0021591)1.91410002
185T-helper cell differentiation (GO:0042093)1.91294903
186CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)1.91294903
187syncytium formation by plasma membrane fusion (GO:0000768)1.91017462

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human3.96338345
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.09246506
3SALL1_21062744_ChIP-ChIP_HESCs_Human2.95046430
4ZNF274_21170338_ChIP-Seq_K562_Hela2.92965558
5VDR_22108803_ChIP-Seq_LS180_Human2.86593519
6AR_21572438_ChIP-Seq_LNCaP_Human2.84094411
7FUS_26573619_Chip-Seq_HEK293_Human2.70821462
8EWS_26573619_Chip-Seq_HEK293_Human2.53554800
9IGF1R_20145208_ChIP-Seq_DFB_Human2.47093043
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.45706463
11TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.17643446
12GBX2_23144817_ChIP-Seq_PC3_Human2.15543990
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.09721335
14CTBP2_25329375_ChIP-Seq_LNCAP_Human2.04012403
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.02465194
16EZH2_22144423_ChIP-Seq_EOC_Human1.99083928
17STAT6_21828071_ChIP-Seq_BEAS2B_Human1.98655951
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.90859185
19POU5F1_16153702_ChIP-ChIP_HESCs_Human1.87216716
20ER_23166858_ChIP-Seq_MCF-7_Human1.80043724
21ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.78410278
22TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.76082650
23BMI1_23680149_ChIP-Seq_NPCS_Mouse1.74465677
24PCGF2_27294783_Chip-Seq_NPCs_Mouse1.72857169
25* MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.71910405
26PCGF2_27294783_Chip-Seq_ESCs_Mouse1.70370211
27ZNF217_24962896_ChIP-Seq_MCF-7_Human1.69894214
28JARID2_20064375_ChIP-Seq_MESCs_Mouse1.68877476
29SOX9_24532713_ChIP-Seq_HFSC_Mouse1.66235047
30SUZ12_27294783_Chip-Seq_NPCs_Mouse1.64921212
31TP53_18474530_ChIP-ChIP_U2OS_Human1.63411721
32KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.62087253
33TCF4_18268006_ChIP-ChIP_LS174T_Human1.61349210
34NOTCH1_21737748_ChIP-Seq_TLL_Human1.61221511
35RNF2_27304074_Chip-Seq_ESCs_Mouse1.61047031
36EZH2_27304074_Chip-Seq_ESCs_Mouse1.60912884
37HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.60167513
38CBX2_27304074_Chip-Seq_ESCs_Mouse1.59141369
39SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.59121109
40TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.57521008
41ELK1_19687146_ChIP-ChIP_HELA_Human1.56661040
42UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.56612590
43SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.56126641
44NFE2_27457419_Chip-Seq_LIVER_Mouse1.56052200
45CDX2_19796622_ChIP-Seq_MESCs_Mouse1.54937333
46TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51834864
47POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.51834864
48SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.47605820
49SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.46927284
50CBP_20019798_ChIP-Seq_JUKART_Human1.46044024
51IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.46044024
52TP53_16413492_ChIP-PET_HCT116_Human1.45919819
53* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.45104597
54OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44755476
55NANOG_18555785_Chip-Seq_ESCs_Mouse1.43349361
56MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.43114756
57AHR_22903824_ChIP-Seq_MCF-7_Human1.42936249
58SMAD4_21799915_ChIP-Seq_A2780_Human1.42850833
59SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.42830387
60MYC_18940864_ChIP-ChIP_HL60_Human1.42826571
61BCAT_22108803_ChIP-Seq_LS180_Human1.42097593
62AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.42068127
63PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.41808095
64ESR1_20079471_ChIP-ChIP_T-47D_Human1.41107154
65EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.39956738
66E2F1_18555785_Chip-Seq_ESCs_Mouse1.39013609
67AR_25329375_ChIP-Seq_VCAP_Human1.38496744
68GABP_17652178_ChIP-ChIP_JURKAT_Human1.38359718
69E2F4_17652178_ChIP-ChIP_JURKAT_Human1.36260665
70CTBP1_25329375_ChIP-Seq_LNCAP_Human1.36246789
71* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36223132
72IRF1_19129219_ChIP-ChIP_H3396_Human1.36026748
73EED_16625203_ChIP-ChIP_MESCs_Mouse1.35812957
74SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.35112246
75FLI1_27457419_Chip-Seq_LIVER_Mouse1.34420079
76SUZ12_18555785_Chip-Seq_ESCs_Mouse1.34300921
77NR3C1_21868756_ChIP-Seq_MCF10A_Human1.34089017
78SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.33980957
79EZH2_27294783_Chip-Seq_NPCs_Mouse1.33656659
80FOXM1_26456572_ChIP-Seq_MCF-7_Human1.31874250
81JARID2_20075857_ChIP-Seq_MESCs_Mouse1.31357936
82EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.30665041
83P300_19829295_ChIP-Seq_ESCs_Human1.29393927
84EZH2_27294783_Chip-Seq_ESCs_Mouse1.28428758
85ARNT_22903824_ChIP-Seq_MCF-7_Human1.26766636
86EZH2_18974828_ChIP-Seq_MESCs_Mouse1.25712341
87RNF2_18974828_ChIP-Seq_MESCs_Mouse1.25712341
88SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.23549037
89CMYC_18555785_Chip-Seq_ESCs_Mouse1.23381518
90EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.22692307
91P53_22387025_ChIP-Seq_ESCs_Mouse1.22549906
92SUZ12_27294783_Chip-Seq_ESCs_Mouse1.22204148
93POU3F2_20337985_ChIP-ChIP_501MEL_Human1.22139600
94EST1_17652178_ChIP-ChIP_JURKAT_Human1.21676378
95PIAS1_25552417_ChIP-Seq_VCAP_Human1.20926175
96ESR1_21235772_ChIP-Seq_MCF-7_Human1.20427323
97TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.20118978
98KLF5_20875108_ChIP-Seq_MESCs_Mouse1.19717451
99DROSHA_22980978_ChIP-Seq_HELA_Human1.19674269
100SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.19624425
101KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.19537438
102P300_18555785_Chip-Seq_ESCs_Mouse1.18364396
103P53_22127205_ChIP-Seq_FIBROBLAST_Human1.18181959
104* NANOG_19829295_ChIP-Seq_ESCs_Human1.17934604
105* SOX2_19829295_ChIP-Seq_ESCs_Human1.17934604
106* STAT3_23295773_ChIP-Seq_U87_Human1.17886193
107GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.17121707
108GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.17082031
109STAT3_18555785_Chip-Seq_ESCs_Mouse1.16065267
110RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.15915364
111TAF15_26573619_Chip-Seq_HEK293_Human1.15596675
112RXR_22108803_ChIP-Seq_LS180_Human1.15407499
113MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.15376709
114OCT4_18555785_Chip-Seq_ESCs_Mouse1.15300037
115TBL1_22424771_ChIP-Seq_293T_Human1.15259596
116RNF2_27304074_Chip-Seq_NSC_Mouse1.14375955
117CDX2_22108803_ChIP-Seq_LS180_Human1.14145706
118* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.14030012
119RUNX2_22187159_ChIP-Seq_PCA_Human1.13237650
120* TCF4_23295773_ChIP-Seq_U87_Human1.12955686
121NMYC_18555785_Chip-Seq_ESCs_Mouse1.12720816
122SMAD3_21741376_ChIP-Seq_EPCs_Human1.12675299
123SOX2_18555785_Chip-Seq_ESCs_Mouse1.12655480
124RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.12546054
125ELK4_26923725_Chip-Seq_MESODERM_Mouse1.12340590
126SMAD_19615063_ChIP-ChIP_OVARY_Human1.12085185
127FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.12060154
128GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10411663
129PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10383712
130PU1_27457419_Chip-Seq_LIVER_Mouse1.10093615
131RBPJ_22232070_ChIP-Seq_NCS_Mouse1.09387142
132CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.09369502
133MTF2_20144788_ChIP-Seq_MESCs_Mouse1.09168755
134OCT4_21477851_ChIP-Seq_ESCs_Mouse1.09137702
135CRX_20693478_ChIP-Seq_RETINA_Mouse1.08554291
136FLI1_21867929_ChIP-Seq_TH2_Mouse1.08474526
137PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.07533122
138* SMAD4_21741376_ChIP-Seq_EPCs_Human1.06722824
139PRDM14_20953172_ChIP-Seq_ESCs_Human1.06569567
140CTCF_18555785_Chip-Seq_ESCs_Mouse1.06263221
141TCF4_22108803_ChIP-Seq_LS180_Human1.05888081
142KLF4_18555785_Chip-Seq_ESCs_Mouse1.05703346
143FOXO3_23340844_ChIP-Seq_DLD1_Human1.05599778
144RUNX1_27457419_Chip-Seq_LIVER_Mouse1.05448941
145ESRRB_18555785_Chip-Seq_ESCs_Mouse1.04076165
146CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03901509
147SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.03750724
148SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.03750724
149STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.99160576
150NANOG_16153702_ChIP-ChIP_HESCs_Human0.98706288
151TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.97903391
152SOX2_16153702_ChIP-ChIP_HESCs_Human0.97309834
153* TBX3_20139965_ChIP-Seq_ESCs_Mouse0.97024925
154KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.96453490
155* TBX3_20139965_ChIP-Seq_MESCs_Mouse0.96200911

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier5.27234623
2MP0003941_abnormal_skin_development4.67619610
3MP0005409_darkened_coat_color4.12767657
4MP0005275_abnormal_skin_tensile4.05780824
5MP0005501_abnormal_skin_physiology3.33840672
6MP0000579_abnormal_nail_morphology2.92052153
7MP0000383_abnormal_hair_follicle2.77727384
8MP0008877_abnormal_DNA_methylation2.72743045
9MP0000015_abnormal_ear_pigmentation2.65610053
10MP0004381_abnormal_hair_follicle2.64053109
11MP0000566_synostosis2.62905749
12MP0005174_abnormal_tail_pigmentation2.62373332
13MP0002060_abnormal_skin_morphology2.54111828
14MP0001188_hyperpigmentation2.48515574
15MP0010678_abnormal_skin_adnexa2.45747960
16MP0001216_abnormal_epidermal_layer2.39870497
17MP0010771_integument_phenotype2.38796358
18MP0000647_abnormal_sebaceous_gland2.38066011
19MP0000427_abnormal_hair_cycle2.31105683
20MP0010234_abnormal_vibrissa_follicle2.15938161
21MP0008057_abnormal_DNA_replication2.08823636
22MP0004947_skin_inflammation2.06232524
23MP0005451_abnormal_body_composition2.05488193
24MP0000569_abnormal_digit_pigmentation1.91290286
25MP0002098_abnormal_vibrissa_morphology1.90439134
26MP0002009_preneoplasia1.87448179
27MP0002254_reproductive_system_inflammat1.77688981
28MP0003718_maternal_effect1.74550758
29MP0009379_abnormal_foot_pigmentation1.72747381
30MP0003880_abnormal_central_pattern1.67481170
31MP0003195_calcinosis1.63367686
32MP0006072_abnormal_retinal_apoptosis1.63208119
33MP0005551_abnormal_eye_electrophysiolog1.58127694
34MP0002177_abnormal_outer_ear1.58035308
35MP0010094_abnormal_chromosome_stability1.57670584
36MP0008058_abnormal_DNA_repair1.54685242
37MP0002938_white_spotting1.53341466
38MP0003950_abnormal_plasma_membrane1.53304718
39MP0000377_abnormal_hair_follicle1.52453064
40MP0003693_abnormal_embryo_hatching1.52114194
41MP0004215_abnormal_myocardial_fiber1.47126709
42MP0005253_abnormal_eye_physiology1.42740443
43MP0003119_abnormal_digestive_system1.42413534
44MP0002095_abnormal_skin_pigmentation1.41690302
45MP0002638_abnormal_pupillary_reflex1.41343130
46MP0001485_abnormal_pinna_reflex1.40322590
47MP0002102_abnormal_ear_morphology1.39990191
48MP0005646_abnormal_pituitary_gland1.38729759
49MP0001293_anophthalmia1.38676988
50MP0005187_abnormal_penis_morphology1.37922901
51MP0000631_abnormal_neuroendocrine_gland1.37298048
52MP0001346_abnormal_lacrimal_gland1.36943493
53MP0003121_genomic_imprinting1.33170536
54MP0002160_abnormal_reproductive_system1.30093586
55MP0002234_abnormal_pharynx_morphology1.29768803
56MP0000372_irregular_coat_pigmentation1.28848401
57MP0002735_abnormal_chemical_nociception1.27754904
58MP0008789_abnormal_olfactory_epithelium1.26900556
59MP0001191_abnormal_skin_condition1.26706693
60MP0000762_abnormal_tongue_morphology1.25810527
61MP0002751_abnormal_autonomic_nervous1.24630046
62MP0003567_abnormal_fetal_cardiomyocyte1.23053960
63MP0004885_abnormal_endolymph1.20974047
64MP0004133_heterotaxia1.20016340
65MP0004270_analgesia1.18683601
66MP0001299_abnormal_eye_distance/1.17188472
67* MP0009046_muscle_twitch1.14460381
68MP0004742_abnormal_vestibular_system1.14147726
69MP0009780_abnormal_chondrocyte_physiolo1.14083267
70MP0003453_abnormal_keratinocyte_physiol1.13327167
71MP0005499_abnormal_olfactory_system1.12567433
72MP0005394_taste/olfaction_phenotype1.12567433
73MP0000538_abnormal_urinary_bladder1.11743764
74MP0008872_abnormal_physiological_respon1.10560591
75MP0009931_abnormal_skin_appearance1.10406124
76MP0000778_abnormal_nervous_system1.08529447
77MP0002837_dystrophic_cardiac_calcinosis1.06764374
78MP0001529_abnormal_vocalization1.06143513
79MP0006292_abnormal_olfactory_placode1.03574816
80MP0005367_renal/urinary_system_phenotyp1.02940147
81MP0000516_abnormal_urinary_system1.02940147
82MP0002233_abnormal_nose_morphology1.02900362
83MP0002090_abnormal_vision1.02686854
84MP0000467_abnormal_esophagus_morphology1.02628603
85MP0001340_abnormal_eyelid_morphology1.02087854
86MP0009745_abnormal_behavioral_response1.01879533
87MP0005423_abnormal_somatic_nervous1.01457317
88MP0003011_delayed_dark_adaptation1.00784883
89MP0001968_abnormal_touch/_nociception1.00769238
90MP0003385_abnormal_body_wall0.97328606
91MP0009384_cardiac_valve_regurgitation0.96097273
92MP0002272_abnormal_nervous_system0.96086687
93MP0004185_abnormal_adipocyte_glucose0.95602137
94MP0003045_fibrosis0.95454510
95MP0004147_increased_porphyrin_level0.94761641
96MP0006276_abnormal_autonomic_nervous0.93119285
97MP0001986_abnormal_taste_sensitivity0.92979958
98MP0005389_reproductive_system_phenotype0.92807486
99MP0001243_abnormal_dermal_layer0.91735039
100MP0000432_abnormal_head_morphology0.90052930
101MP0001177_atelectasis0.89196537
102MP0002734_abnormal_mechanical_nocicepti0.87235935
103MP0004142_abnormal_muscle_tone0.86883051
104MP0004957_abnormal_blastocyst_morpholog0.86738099
105MP0000367_abnormal_coat/_hair0.86420612
106MP0003755_abnormal_palate_morphology0.86227514
107MP0003137_abnormal_impulse_conducting0.85369010
108MP0005391_vision/eye_phenotype0.84953372
109MP0004043_abnormal_pH_regulation0.84721737
110MP0005386_behavior/neurological_phenoty0.84698124
111MP0004924_abnormal_behavior0.84698124
112MP0002249_abnormal_larynx_morphology0.80884092
113MP0008438_abnormal_cutaneous_collagen0.80363917
114MP0003122_maternal_imprinting0.80266671
115MP0001929_abnormal_gametogenesis0.80157856
116MP0002282_abnormal_trachea_morphology0.79955982
117MP0002277_abnormal_respiratory_mucosa0.79625739
118MP0009697_abnormal_copulation0.78440089
119MP0002210_abnormal_sex_determination0.76790167
120MP0003646_muscle_fatigue0.76407243
121MP0006054_spinal_hemorrhage0.76390103
122MP0001486_abnormal_startle_reflex0.76316869
123MP0001984_abnormal_olfaction0.75953837
124MP0002876_abnormal_thyroid_physiology0.75500952
125MP0000653_abnormal_sex_gland0.75107001
126MP0001324_abnormal_eye_pigmentation0.74939321
127MP0000537_abnormal_urethra_morphology0.74899229
128MP0009250_abnormal_appendicular_skeleto0.74425062
129MP0003890_abnormal_embryonic-extraembry0.74048936
130MP0000627_abnormal_mammary_gland0.70870769
131MP0005503_abnormal_tendon_morphology0.69966348
132MP0002736_abnormal_nociception_after0.67378028
133MP0003938_abnormal_ear_development0.67171665
134MP0003937_abnormal_limbs/digits/tail_de0.66924460
135MP0000428_abnormal_craniofacial_morphol0.66681998
136MP0005171_absent_coat_pigmentation0.63880698
137MP0002697_abnormal_eye_size0.63874126
138MP0005257_abnormal_intraocular_pressure0.63114965
139MP0002111_abnormal_tail_morphology0.62929064
140MP0003705_abnormal_hypodermis_morpholog0.62360517
141MP0010386_abnormal_urinary_bladder0.60777780
142* MP0002184_abnormal_innervation0.60751781
143MP0003136_yellow_coat_color0.59926469
144MP0005248_abnormal_Harderian_gland0.59857976
145MP0002733_abnormal_thermal_nociception0.59798003
146MP0002557_abnormal_social/conspecific_i0.59227522
147MP0002116_abnormal_craniofacial_bone0.59165942
148MP0004782_abnormal_surfactant_physiolog0.58436890
149MP0005388_respiratory_system_phenotype0.58129706
150MP0002133_abnormal_respiratory_system0.58129706
151MP0003935_abnormal_craniofacial_develop0.57381756
152MP0001186_pigmentation_phenotype0.56612772
153MP0003787_abnormal_imprinting0.55220015
154MP0003861_abnormal_nervous_system0.55111750
155MP0004858_abnormal_nervous_system0.54756516
156MP0000049_abnormal_middle_ear0.53828163
157MP0002109_abnormal_limb_morphology0.53800737
158MP0001286_abnormal_eye_development0.53236825
159MP0003936_abnormal_reproductive_system0.51151101

Predicted human phenotypes

RankGene SetZ-score
1Renovascular hypertension (HP:0100817)4.67459756
2Elfin facies (HP:0004428)4.66727052
3Overriding aorta (HP:0002623)4.59165481
4Flat cornea (HP:0007720)4.48579374
5Hyperacusis (HP:0010780)4.38267618
6Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.13179686
7Renal duplication (HP:0000075)3.95186556
8Toxemia of pregnancy (HP:0100603)3.71633078
9Congenital ichthyosiform erythroderma (HP:0007431)3.70312217
10Insomnia (HP:0100785)3.52864121
11Hypotrichosis (HP:0001006)3.44662078
12Increased IgE level (HP:0003212)3.44116036
13Abnormality of the diencephalon (HP:0010662)3.40683457
14Lip pit (HP:0100267)3.36201432
15Pancreatic cysts (HP:0001737)3.29644582
16Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.18778603
17Absent/shortened dynein arms (HP:0200106)3.18641284
18Dynein arm defect of respiratory motile cilia (HP:0012255)3.18641284
19Parakeratosis (HP:0001036)3.07029771
20Ectropion (HP:0000656)2.99361905
21Abnormality of the labia minora (HP:0012880)2.95484475
22Abnormal respiratory motile cilium physiology (HP:0012261)2.94746802
23True hermaphroditism (HP:0010459)2.92124574
24Pancreatic fibrosis (HP:0100732)2.91442824
25Bladder diverticulum (HP:0000015)2.79255501
26Chromosomal breakage induced by crosslinking agents (HP:0003221)2.73604625
27Woolly hair (HP:0002224)2.61441109
28Increased nuchal translucency (HP:0010880)2.58991997
29Milia (HP:0001056)2.56729819
30Plantar hyperkeratosis (HP:0007556)2.56071890
31Bowel diverticulosis (HP:0005222)2.51434568
32Erythroderma (HP:0001019)2.48729654
33Aplasia cutis congenita (HP:0001057)2.47025451
34Abnormality of the axillary hair (HP:0100134)2.46629559
35Abnormality of secondary sexual hair (HP:0009888)2.46629559
36Abnormal respiratory epithelium morphology (HP:0012253)2.46217827
37Abnormal respiratory motile cilium morphology (HP:0005938)2.46217827
38Aplasia/Hypoplasia of the uvula (HP:0010293)2.45397770
39Abnormality of the carotid arteries (HP:0005344)2.44222450
40Abnormality of nail color (HP:0100643)2.44018749
41Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.41911537
42Chromsome breakage (HP:0040012)2.39544913
43Meckel diverticulum (HP:0002245)2.38886293
44Abnormality of midbrain morphology (HP:0002418)2.37507267
45Molar tooth sign on MRI (HP:0002419)2.37507267
46Abnormality of the ileum (HP:0001549)2.35860084
47Onycholysis (HP:0001806)2.35853298
48Rhinitis (HP:0012384)2.33965800
49Patellar dislocation (HP:0002999)2.32783732
50Distal lower limb muscle weakness (HP:0009053)2.32603895
51Palmar hyperkeratosis (HP:0010765)2.31906161
52Abnormality of the gastric mucosa (HP:0004295)2.31886197
53Corneal erosion (HP:0200020)2.30261860
54Abnormality of chromosome stability (HP:0003220)2.29739537
55Palmoplantar hyperkeratosis (HP:0000972)2.29408121
56Abnormal ciliary motility (HP:0012262)2.27265980
57Medial flaring of the eyebrow (HP:0010747)2.26348350
58Thick nail (HP:0001805)2.26141298
59Atrophic scars (HP:0001075)2.25220396
60Stenosis of the external auditory canal (HP:0000402)2.24823905
61Colon cancer (HP:0003003)2.22820712
62Short hallux (HP:0010109)2.22385258
63Hypoplastic labia majora (HP:0000059)2.22165674
64Nephronophthisis (HP:0000090)2.21651520
65Long nose (HP:0003189)2.20868431
66Sparse scalp hair (HP:0002209)2.18904179
67Aplasia/Hypoplasia of the hallux (HP:0008362)2.18340077
68Aplasia/Hypoplasia of the tibia (HP:0005772)2.17667580
69Upper limb muscle weakness (HP:0003484)2.16295242
70Abnormality of the nasal septum (HP:0000419)2.14882871
71Distal lower limb amyotrophy (HP:0008944)2.13993283
72Preaxial hand polydactyly (HP:0001177)2.11647293
73Duplicated collecting system (HP:0000081)2.11607629
74Median cleft lip (HP:0000161)2.11364592
75Labial hypoplasia (HP:0000066)2.10507692
76Febrile seizures (HP:0002373)2.09640859
77Hypohidrosis (HP:0000966)2.07695317
78Genital tract atresia (HP:0001827)2.07206041
79Everted lower lip vermilion (HP:0000232)2.05818122
80Progressive cerebellar ataxia (HP:0002073)2.05673532
81Erythema (HP:0010783)2.05651296
82Clubbing of toes (HP:0100760)2.03387387
83Vaginal atresia (HP:0000148)2.03240011
84Progressive inability to walk (HP:0002505)2.03154927
85Lower limb amyotrophy (HP:0007210)2.02315729
86Methylmalonic acidemia (HP:0002912)2.02310291
87Hypothermia (HP:0002045)2.01694663
88Megalocornea (HP:0000485)2.00660565
89Abnormality of the labia majora (HP:0012881)2.00344148
90Polygenic inheritance (HP:0010982)1.99015304
91Congenital stationary night blindness (HP:0007642)1.98910090
92Fragile nails (HP:0001808)1.96973699
93Abnormality of the renal cortex (HP:0011035)1.96738985
94Chronic hepatic failure (HP:0100626)1.94941998
95Hypoplastic female external genitalia (HP:0012815)1.94850217
96Pendular nystagmus (HP:0012043)1.92616978
97Aplasia/Hypoplasia of the tongue (HP:0010295)1.92093218
98Abnormality of the renal medulla (HP:0100957)1.91480874
99Absent radius (HP:0003974)1.90624136
100Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.90534593
101Abnormality of the renal collecting system (HP:0004742)1.90428264
102Glioma (HP:0009733)1.89734907
103Absent forearm bone (HP:0003953)1.89161525
104Aplasia involving forearm bones (HP:0009822)1.89161525
105Astrocytoma (HP:0009592)1.88740853
106Abnormality of the astrocytes (HP:0100707)1.88740853
107Gait imbalance (HP:0002141)1.88544276
108Neoplasm of the adrenal cortex (HP:0100641)1.88199323
109Furrowed tongue (HP:0000221)1.87190494
110Congenital primary aphakia (HP:0007707)1.86110196
111Arnold-Chiari malformation (HP:0002308)1.84594404
112Gaze-evoked nystagmus (HP:0000640)1.84062814
113Absent eyebrow (HP:0002223)1.83966578
114Ependymoma (HP:0002888)1.82933881
115Deep philtrum (HP:0002002)1.82774166
116Hyperventilation (HP:0002883)1.81961868
117Gangrene (HP:0100758)1.80974864
118Microglossia (HP:0000171)1.80833789
119Inability to walk (HP:0002540)1.80514150
120Anophthalmia (HP:0000528)1.79293010
121Abolished electroretinogram (ERG) (HP:0000550)1.78532972
122Submucous cleft hard palate (HP:0000176)1.78281433
123Birth length less than 3rd percentile (HP:0003561)1.77497340
124Type II lissencephaly (HP:0007260)1.77240275
125Nail dystrophy (HP:0008404)1.77027158
126Optic nerve hypoplasia (HP:0000609)1.76330997
127Intestinal atresia (HP:0011100)1.75526944
128Short tibia (HP:0005736)1.75491452
129Cupped ear (HP:0000378)1.75391572
130Volvulus (HP:0002580)1.74593815
131Anencephaly (HP:0002323)1.74277918
132Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.73208574
133Sloping forehead (HP:0000340)1.73179358
134Alopecia of scalp (HP:0002293)1.73162579
135Absent thumb (HP:0009777)1.73017351
136Pruritus (HP:0000989)1.72940437
137Nephrogenic diabetes insipidus (HP:0009806)1.72858209
138Advanced eruption of teeth (HP:0006288)1.72583724
139Broad-based gait (HP:0002136)1.72444068
140Small intestinal stenosis (HP:0012848)1.72390187
141Duodenal stenosis (HP:0100867)1.72390187
142Tubular atrophy (HP:0000092)1.71852332
143Sclerocornea (HP:0000647)1.71232047
144Small hand (HP:0200055)1.70988223
145Chorioretinal atrophy (HP:0000533)1.69134966
146Hamartoma of the eye (HP:0010568)1.68508313
147Concave nail (HP:0001598)1.68349906
148Cystic liver disease (HP:0006706)1.67504920
149Dandy-Walker malformation (HP:0001305)1.66490612
150Triphalangeal thumb (HP:0001199)1.66271142
151Aqueductal stenosis (HP:0002410)1.64991212
152Poor coordination (HP:0002370)1.64778239
153Cutaneous syndactyly (HP:0012725)1.64750411
154Abnormality of the duodenum (HP:0002246)1.64617006
155Lissencephaly (HP:0001339)1.64010097
156Follicular hyperkeratosis (HP:0007502)1.63710290
157Right ventricular cardiomyopathy (HP:0011663)1.63678894
158Obsessive-compulsive behavior (HP:0000722)1.63459930
159Oligodactyly (hands) (HP:0001180)1.62217730
160Abnormality of the phalanges of the 5th finger (HP:0004213)1.62114428
161Broad alveolar ridges (HP:0000187)1.62068778
162Neoplasm of the oral cavity (HP:0100649)1.61437687
163Urethral obstruction (HP:0000796)1.60845618
164Male pseudohermaphroditism (HP:0000037)1.60285825
165Periorbital edema (HP:0100539)1.60243073
166Abnormality of incisor morphology (HP:0011063)1.60221086
167Natal tooth (HP:0000695)1.59879511
168Spina bifida occulta (HP:0003298)1.52905637
169Ectopic kidney (HP:0000086)1.52540719
170Fragile skin (HP:0001030)1.52061154
171Chronic bronchitis (HP:0004469)1.49813081
172Ulnar claw (HP:0001178)1.49626598
173Hallux valgus (HP:0001822)1.49599057
174Abnormality of the parietal bone (HP:0002696)1.49199929
175Abnormality of the preputium (HP:0100587)1.48834325
176Septate vagina (HP:0001153)1.48219855
177Aplasia involving bones of the extremities (HP:0009825)1.47113843
178Aplasia involving bones of the upper limbs (HP:0009823)1.47113843
179Aplasia of the phalanges of the hand (HP:0009802)1.47113843
180Microdontia (HP:0000691)1.45454146
181Deviation of the hallux (HP:0010051)1.45156181
182Facial edema (HP:0000282)1.44662596
183Oligodontia (HP:0000677)1.44491667
184Abnormal hair whorl (HP:0010721)1.44125767
185Prostate neoplasm (HP:0100787)1.43590687
186Chin dimple (HP:0010751)1.43121654
187Popliteal pterygium (HP:0009756)1.42420975
188Malignant hyperthermia (HP:0002047)1.42138019

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.60057637
2YES13.28402455
3WNK32.73510500
4CASK2.73217725
5TRIM282.69730692
6MAP3K92.51061338
7LATS12.33917039
8PINK12.16856047
9CDK122.15547254
10GRK12.14868116
11ACVR1B2.03826536
12SGK21.96457765
13AKT31.94437889
14STK391.92196932
15BRSK21.88706820
16ZAK1.85786771
17EPHB21.83580234
18EIF2AK31.78858547
19PDGFRB1.61794373
20MAP4K21.60018490
21SGK31.59311457
22EIF2AK21.53843782
23BMPR1B1.51625401
24NTRK21.51605619
25MARK11.50836521
26TGFBR11.50791819
27BRD41.48751008
28OXSR11.47857093
29MST1R1.47678953
30INSRR1.45341356
31SRPK11.44974189
32EPHA31.44435564
33NUAK11.43548717
34STK31.42539150
35ADRBK21.40939422
36TAF11.37048655
37SGK4941.36229126
38SGK2231.36229126
39BUB11.35259542
40PLK31.32466125
41TSSK61.32028716
42MKNK21.31311453
43CSNK1G11.31017782
44WEE11.27171275
45PKN11.27061930
46TNIK1.23469831
47MST41.21791238
48CAMK1G1.20748774
49PLK41.19764847
50CSNK1A1L1.18973889
51MKNK11.14213519
52LATS21.13439035
53CSNK1G21.12101157
54MAP3K21.10033827
55CLK11.08533598
56CSNK1G31.06071983
57FER1.05724452
58MARK21.04417687
59MAP2K71.04282612
60PAK31.02232288
61DMPK1.00965665
62EPHA41.00774410
63CDK30.99895865
64TRPM70.96683765
65PIK3CA0.93193689
66WNK40.92573015
67MAPK130.92434287
68NEK60.91568736
69PRKCG0.91468389
70CDC70.90925410
71SIK20.89734735
72BLK0.88678052
73WNK10.88311976
74HCK0.86863358
75ERBB30.86454965
76FGFR10.85394034
77PRKD20.85294712
78STK240.85080102
79SGK10.82336708
80VRK10.80682143
81IRAK30.80215169
82NLK0.79699192
83STK38L0.79227607
84PLK10.78834967
85FGFR20.78339800
86PLK20.77379785
87MAP3K140.76396369
88MAP3K40.75093772
89GRK70.74625719
90PBK0.74142383
91TLK10.74071986
92TTK0.73420751
93SIK30.71664306
94STK40.70901835
95NTRK30.70352028
96STK110.69402102
97EIF2AK10.69002139
98IRAK20.68677479
99FGFR30.66833607
100MAPK100.66603644
101RPS6KA20.65505522
102GRK50.65009723
103PRKCE0.64460274
104MAPKAPK20.63688881
105EPHA20.63078710
106EPHB10.60392885
107PRKG10.60339696
108MAPK70.59306898
109DYRK20.59183985
110MINK10.58418496
111PNCK0.58050353
112CDK60.58044731
113ADRBK10.58009034
114DDR20.57804972
115CSNK1D0.57664275
116CHEK20.57603456
117CAMK1D0.57505821
118NEK10.55730375
119HIPK20.55217261
120ABL10.54422134
121BCR0.51935472
122NTRK10.50768752
123IRAK10.50203568
124MTOR0.50013239
125BRSK10.49679162
126ATR0.49490933
127DYRK1A0.48519771
128MAPKAPK30.47887838
129ERBB40.46841934
130MAPKAPK50.46589425
131TIE10.46045725
132ATM0.45893650
133STK380.45648180
134OBSCN0.45267411
135RPS6KB10.44108603
136FYN0.44073674
137MAPK80.43552048
138SYK0.42994408
139NEK90.42598210
140PRKCI0.42269980
141CDK90.42007105
142BMPR20.41903234
143CSNK1A10.40120269
144CAMK2A0.39134210
145ROCK10.38926904
146FGR0.38566678
147MAP3K30.38526259
148CDC42BPA0.37116765
149DYRK30.37044703
150MAP2K40.36179768
151RPS6KA40.35412374
152MAP3K120.34848330
153RPS6KA50.34692841
154PHKG20.34271008
155PHKG10.34271008
156CSNK1E0.33981333
157MELK0.28552775
158ERBB20.26615678
159PRKAA10.25668630

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.27591749
2Basal transcription factors_Homo sapiens_hsa030222.24026085
3Selenocompound metabolism_Homo sapiens_hsa004502.17799527
4Protein export_Homo sapiens_hsa030601.96984108
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.96449556
6Dorso-ventral axis formation_Homo sapiens_hsa043201.92072183
7Nitrogen metabolism_Homo sapiens_hsa009101.91256152
8Sphingolipid metabolism_Homo sapiens_hsa006001.90341636
9Propanoate metabolism_Homo sapiens_hsa006401.81009714
10RNA degradation_Homo sapiens_hsa030181.77505972
11Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.71200014
12Axon guidance_Homo sapiens_hsa043601.69253730
13Butanoate metabolism_Homo sapiens_hsa006501.68743334
14Circadian rhythm_Homo sapiens_hsa047101.65636103
15Vitamin B6 metabolism_Homo sapiens_hsa007501.60246076
16RNA polymerase_Homo sapiens_hsa030201.59725967
17Basal cell carcinoma_Homo sapiens_hsa052171.59288279
18ErbB signaling pathway_Homo sapiens_hsa040121.56930233
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.53829261
20Ether lipid metabolism_Homo sapiens_hsa005651.49661231
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.42246751
22Phototransduction_Homo sapiens_hsa047441.41173522
23Caffeine metabolism_Homo sapiens_hsa002321.39753580
24Phosphatidylinositol signaling system_Homo sapiens_hsa040701.38866486
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.37603624
26Serotonergic synapse_Homo sapiens_hsa047261.37383217
27Mismatch repair_Homo sapiens_hsa034301.35088692
28One carbon pool by folate_Homo sapiens_hsa006701.30739198
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.30228120
30RNA transport_Homo sapiens_hsa030131.28943791
31Proteasome_Homo sapiens_hsa030501.25185820
32Linoleic acid metabolism_Homo sapiens_hsa005911.22533355
33Steroid biosynthesis_Homo sapiens_hsa001001.20660146
34Fanconi anemia pathway_Homo sapiens_hsa034601.19130580
35Gastric acid secretion_Homo sapiens_hsa049711.18792900
36Maturity onset diabetes of the young_Homo sapiens_hsa049501.15691768
37Long-term depression_Homo sapiens_hsa047301.14420329
38Hedgehog signaling pathway_Homo sapiens_hsa043401.13188209
39Taste transduction_Homo sapiens_hsa047421.12298613
40Wnt signaling pathway_Homo sapiens_hsa043101.10864150
41Melanogenesis_Homo sapiens_hsa049161.09825500
42MicroRNAs in cancer_Homo sapiens_hsa052061.09721681
43Tryptophan metabolism_Homo sapiens_hsa003801.09500463
44Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.08795910
45Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.08486392
46Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.07880003
47Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.06649230
48Glutamatergic synapse_Homo sapiens_hsa047241.05546193
49Cysteine and methionine metabolism_Homo sapiens_hsa002701.05421620
50Olfactory transduction_Homo sapiens_hsa047401.04675612
51Hippo signaling pathway_Homo sapiens_hsa043901.03184916
52GnRH signaling pathway_Homo sapiens_hsa049121.02749628
53Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.01151096
54Nicotine addiction_Homo sapiens_hsa050331.00595287
55Regulation of autophagy_Homo sapiens_hsa041401.00418957
56Sphingolipid signaling pathway_Homo sapiens_hsa040710.99176621
57Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97781424
58Nucleotide excision repair_Homo sapiens_hsa034200.97397370
59Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.97118673
60Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.96973795
61ECM-receptor interaction_Homo sapiens_hsa045120.96368786
62Arachidonic acid metabolism_Homo sapiens_hsa005900.96348454
63Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.95766065
64Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.93328539
65Oocyte meiosis_Homo sapiens_hsa041140.92975633
66Melanoma_Homo sapiens_hsa052180.92824846
67Adherens junction_Homo sapiens_hsa045200.92191112
68Renin secretion_Homo sapiens_hsa049240.90394392
69T cell receptor signaling pathway_Homo sapiens_hsa046600.90262539
70Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.89583884
71Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.89260450
72Choline metabolism in cancer_Homo sapiens_hsa052310.89140592
73Circadian entrainment_Homo sapiens_hsa047130.87505893
74Ras signaling pathway_Homo sapiens_hsa040140.86950113
75Chronic myeloid leukemia_Homo sapiens_hsa052200.86948449
76Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.86571698
77Oxidative phosphorylation_Homo sapiens_hsa001900.85753220
78Phospholipase D signaling pathway_Homo sapiens_hsa040720.85751537
79Salivary secretion_Homo sapiens_hsa049700.85593949
80Tight junction_Homo sapiens_hsa045300.85507000
81GABAergic synapse_Homo sapiens_hsa047270.85479357
82Histidine metabolism_Homo sapiens_hsa003400.84617620
83Morphine addiction_Homo sapiens_hsa050320.83764596
84Endometrial cancer_Homo sapiens_hsa052130.83302337
85Cholinergic synapse_Homo sapiens_hsa047250.83156914
86Glioma_Homo sapiens_hsa052140.82359499
87Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.82194868
88Peroxisome_Homo sapiens_hsa041460.81765469
89MAPK signaling pathway_Homo sapiens_hsa040100.81622830
90Mineral absorption_Homo sapiens_hsa049780.80864450
91Homologous recombination_Homo sapiens_hsa034400.80617169
92Fatty acid elongation_Homo sapiens_hsa000620.79980357
93Viral myocarditis_Homo sapiens_hsa054160.78847221
94Rap1 signaling pathway_Homo sapiens_hsa040150.78092917
95Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.77830307
96Regulation of actin cytoskeleton_Homo sapiens_hsa048100.76927884
97Cell cycle_Homo sapiens_hsa041100.76160276
98Proteoglycans in cancer_Homo sapiens_hsa052050.75983481
99Vascular smooth muscle contraction_Homo sapiens_hsa042700.75972397
100Retinol metabolism_Homo sapiens_hsa008300.75951146
101Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.75746862
102Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.75461776
103Calcium signaling pathway_Homo sapiens_hsa040200.74993648
104TGF-beta signaling pathway_Homo sapiens_hsa043500.74825022
105Dopaminergic synapse_Homo sapiens_hsa047280.74036364
106Autoimmune thyroid disease_Homo sapiens_hsa053200.73486507
107Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.73171216
108beta-Alanine metabolism_Homo sapiens_hsa004100.72606796
109DNA replication_Homo sapiens_hsa030300.72212697
110Pathways in cancer_Homo sapiens_hsa052000.71888068
111Oxytocin signaling pathway_Homo sapiens_hsa049210.71756923
112cAMP signaling pathway_Homo sapiens_hsa040240.70268443
113Prostate cancer_Homo sapiens_hsa052150.70182385
114Long-term potentiation_Homo sapiens_hsa047200.68867162
115Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.68021283
116Inositol phosphate metabolism_Homo sapiens_hsa005620.67773373
117Purine metabolism_Homo sapiens_hsa002300.67407865
118Chemical carcinogenesis_Homo sapiens_hsa052040.67266524
119Gap junction_Homo sapiens_hsa045400.66927879
120Jak-STAT signaling pathway_Homo sapiens_hsa046300.66487629
121Steroid hormone biosynthesis_Homo sapiens_hsa001400.66459189
122Transcriptional misregulation in cancer_Homo sapiens_hsa052020.66282883
123Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.65772066
124Ovarian steroidogenesis_Homo sapiens_hsa049130.65461822
125Alcoholism_Homo sapiens_hsa050340.64921595
126Estrogen signaling pathway_Homo sapiens_hsa049150.64343445
127Non-homologous end-joining_Homo sapiens_hsa034500.63698453
128Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.63223722
129Primary bile acid biosynthesis_Homo sapiens_hsa001200.63135376
130Non-small cell lung cancer_Homo sapiens_hsa052230.62338431
131Hematopoietic cell lineage_Homo sapiens_hsa046400.61611866
132Neurotrophin signaling pathway_Homo sapiens_hsa047220.61273580
133Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.60929609
134Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.60423943
135Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.60229438
136Aldosterone synthesis and secretion_Homo sapiens_hsa049250.59994210
137Insulin secretion_Homo sapiens_hsa049110.59607016
138ABC transporters_Homo sapiens_hsa020100.59444600
139Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.59321084
140Parkinsons disease_Homo sapiens_hsa050120.58442162
141Amphetamine addiction_Homo sapiens_hsa050310.57785909
142mRNA surveillance pathway_Homo sapiens_hsa030150.56774972
143Protein digestion and absorption_Homo sapiens_hsa049740.56735280
144Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.56735110
145Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.56716961
146Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56638658
147Chemokine signaling pathway_Homo sapiens_hsa040620.55680827
148Renal cell carcinoma_Homo sapiens_hsa052110.55496831
149Pentose and glucuronate interconversions_Homo sapiens_hsa000400.55374831
150cGMP-PKG signaling pathway_Homo sapiens_hsa040220.54926739
151Hepatitis C_Homo sapiens_hsa051600.54568728
152Endocytosis_Homo sapiens_hsa041440.54418929
153Focal adhesion_Homo sapiens_hsa045100.54137882
154Vitamin digestion and absorption_Homo sapiens_hsa049770.53757802
155p53 signaling pathway_Homo sapiens_hsa041150.53744340
156Huntingtons disease_Homo sapiens_hsa050160.52636021
157Metabolic pathways_Homo sapiens_hsa011000.51810771
158Lysine degradation_Homo sapiens_hsa003100.50737080
159Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.46860971
160Spliceosome_Homo sapiens_hsa030400.44642714

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