GANAB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the alpha subunit of glucosidase II and a member of the glycosyl hydrolase 31 family of proteins. The heterodimeric enzyme glucosidase II plays a role in protein folding and quality control by cleaving glucose residues from immature glycoproteins in the endoplasmic reticulum. Expression of the encoded protein is elevated in lung tumor tissue and in response to UV irradiation. Mutations in this gene cause autosomal-dominant polycystic kidney and liver disease. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)5.04555043
2Golgi transport vesicle coating (GO:0048200)5.04555043
3alpha-linolenic acid metabolic process (GO:0036109)4.27796039
4planar cell polarity pathway involved in neural tube closure (GO:0090179)3.99446579
5proline biosynthetic process (GO:0006561)3.94204696
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.92066875
7L-phenylalanine catabolic process (GO:0006559)3.92066875
8regulation of cholesterol homeostasis (GO:2000188)3.84780760
9DNA unwinding involved in DNA replication (GO:0006268)3.83596790
10L-phenylalanine metabolic process (GO:0006558)3.81554837
11erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.81554837
12sulfur amino acid catabolic process (GO:0000098)3.80026527
134-hydroxyproline metabolic process (GO:0019471)3.79316070
14basement membrane organization (GO:0071711)3.78854891
15negative regulation of fibrinolysis (GO:0051918)3.78277253
16adherens junction assembly (GO:0034333)3.73695622
17regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.68819296
18protein localization to endosome (GO:0036010)3.68643862
19lysine metabolic process (GO:0006553)3.65224503
20lysine catabolic process (GO:0006554)3.65224503
21cell-substrate adherens junction assembly (GO:0007045)3.61408223
22focal adhesion assembly (GO:0048041)3.61408223
23homocysteine metabolic process (GO:0050667)3.60066570
24cell-substrate junction assembly (GO:0007044)3.59224327
25activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.57183333
26mitotic chromosome condensation (GO:0007076)3.55684522
27protein carboxylation (GO:0018214)3.50464376
28peptidyl-glutamic acid carboxylation (GO:0017187)3.50464376
29folic acid-containing compound biosynthetic process (GO:0009396)3.48329185
30positive regulation of nuclease activity (GO:0032075)3.48266554
31skin morphogenesis (GO:0043589)3.47120234
32cysteine metabolic process (GO:0006534)3.41887832
33cytoskeletal anchoring at plasma membrane (GO:0007016)3.39886324
34hemidesmosome assembly (GO:0031581)3.39532028
35triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.35359272
36urea metabolic process (GO:0019627)3.32865373
37urea cycle (GO:0000050)3.32865373
38COPII vesicle coating (GO:0048208)3.31982913
39complement activation, alternative pathway (GO:0006957)3.31047482
40regulation of mammary gland epithelial cell proliferation (GO:0033599)3.28226660
41aromatic amino acid family catabolic process (GO:0009074)3.27646328
42regulation of protein activation cascade (GO:2000257)3.25534186
43regulation of translational fidelity (GO:0006450)3.25117974
44regulation of fatty acid beta-oxidation (GO:0031998)3.24558475
45regulation of fibrinolysis (GO:0051917)3.24411411
46activation of Rac GTPase activity (GO:0032863)3.24054986
47cell adhesion mediated by integrin (GO:0033627)3.22471411
48maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.22338065
49regulation of early endosome to late endosome transport (GO:2000641)3.22123409
50epithelial cell-cell adhesion (GO:0090136)3.21735174
51glycine metabolic process (GO:0006544)3.19081218
52glyoxylate metabolic process (GO:0046487)3.18543693
53regulation of nuclease activity (GO:0032069)3.17319566
54negative regulation of sterol transport (GO:0032372)3.17202242
55negative regulation of cholesterol transport (GO:0032375)3.17202242
56regulation of glucose import in response to insulin stimulus (GO:2001273)3.17000400
57kynurenine metabolic process (GO:0070189)3.16421297
58endoplasmic reticulum unfolded protein response (GO:0030968)3.14203412
59positive regulation of histone deacetylation (GO:0031065)3.13410953
60desmosome organization (GO:0002934)3.12950062
61regulation of complement activation (GO:0030449)3.10976914
62positive regulation of fatty acid beta-oxidation (GO:0032000)3.08715152
63cellular modified amino acid catabolic process (GO:0042219)3.06614341
64negative regulation of cell size (GO:0045792)3.04683462
65high-density lipoprotein particle remodeling (GO:0034375)3.03960990
66cellular response to unfolded protein (GO:0034620)2.98017429
67spliceosomal tri-snRNP complex assembly (GO:0000244)2.96012025
68one-carbon metabolic process (GO:0006730)2.95577130
69retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.94247372
70tetrahydrofolate metabolic process (GO:0046653)2.93976211
71serine family amino acid catabolic process (GO:0009071)2.92710310
72nuclear pore complex assembly (GO:0051292)2.92203635
73semaphorin-plexin signaling pathway (GO:0071526)2.92161793
74reverse cholesterol transport (GO:0043691)2.91286811
75ER-nucleus signaling pathway (GO:0006984)2.90856801
76regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.90832613
77apoptotic cell clearance (GO:0043277)2.88749750
78regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.86226734
79bile acid biosynthetic process (GO:0006699)2.86192454
80maternal placenta development (GO:0001893)2.85838805
81nitrogen cycle metabolic process (GO:0071941)2.84745476
82embryonic process involved in female pregnancy (GO:0060136)2.84002091
83low-density lipoprotein particle clearance (GO:0034383)2.83775590
84protein retention in ER lumen (GO:0006621)2.81628402
85protein maturation by protein folding (GO:0022417)2.81323056
86apoptotic process involved in morphogenesis (GO:0060561)2.81256718
87peptidyl-proline hydroxylation (GO:0019511)2.79857828
88glucose catabolic process (GO:0006007)2.78838498
89heterochromatin organization (GO:0070828)2.78357891
90membrane protein ectodomain proteolysis (GO:0006509)2.76794629
91endodermal cell differentiation (GO:0035987)2.76163882
92serine family amino acid biosynthetic process (GO:0009070)2.76158742
93regulation of histone H3-K27 methylation (GO:0061085)2.75948630
94dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.75935505
95positive regulation of hormone biosynthetic process (GO:0046886)2.75522887
96pore complex assembly (GO:0046931)2.75504133
97regulation of RNA export from nucleus (GO:0046831)2.75098844
98regulation of nucleobase-containing compound transport (GO:0032239)2.74934194
99negative regulation of lipid transport (GO:0032369)2.74310909
100nuclear pore organization (GO:0006999)2.74067820
101cellular response to topologically incorrect protein (GO:0035967)2.72460076
102positive regulation of blood vessel endothelial cell migration (GO:0043536)2.72423462
103glucose 6-phosphate metabolic process (GO:0051156)2.72402812
104pentose-phosphate shunt (GO:0006098)2.72233343
105barbed-end actin filament capping (GO:0051016)2.71968145
106serine family amino acid metabolic process (GO:0009069)2.71216935
107epoxygenase P450 pathway (GO:0019373)2.70976086
108lipoprotein metabolic process (GO:0042157)2.70762867
109plasma lipoprotein particle clearance (GO:0034381)2.70496903
110pinocytosis (GO:0006907)2.70403429
111tryptophan catabolic process (GO:0006569)2.69645605
112indole-containing compound catabolic process (GO:0042436)2.69645605
113indolalkylamine catabolic process (GO:0046218)2.69645605
114intestinal cholesterol absorption (GO:0030299)2.68838434
115ethanol oxidation (GO:0006069)2.67818683
116tryptophan metabolic process (GO:0006568)2.67584243
117Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.66378111
118paraxial mesoderm development (GO:0048339)2.66259118
119fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.65630335
120cellular response to epidermal growth factor stimulus (GO:0071364)2.65306095
121valine metabolic process (GO:0006573)2.65229835
122proline metabolic process (GO:0006560)2.64204838
123protein hydroxylation (GO:0018126)2.64092787
124stress fiber assembly (GO:0043149)2.63180047
125epithelial cell differentiation involved in prostate gland development (GO:0060742)2.61988287
126imidazole-containing compound metabolic process (GO:0052803)2.61918977
127tricarboxylic acid metabolic process (GO:0072350)2.61220898
128midgut development (GO:0007494)2.61027061
129convergent extension (GO:0060026)2.60510461
130glucocorticoid receptor signaling pathway (GO:0042921)2.60144555
131regulation of NFAT protein import into nucleus (GO:0051532)2.59594499
132dicarboxylic acid biosynthetic process (GO:0043650)2.59426593
133protein export from nucleus (GO:0006611)2.59333906
134positive regulation of triglyceride biosynthetic process (GO:0010867)2.58924269
135establishment of apical/basal cell polarity (GO:0035089)2.58717300
136acylglycerol homeostasis (GO:0055090)2.58634494
137triglyceride homeostasis (GO:0070328)2.58634494
138RNA stabilization (GO:0043489)2.58583747
139mRNA stabilization (GO:0048255)2.58583747
140branching involved in mammary gland duct morphogenesis (GO:0060444)2.58396583
1412-oxoglutarate metabolic process (GO:0006103)2.58234078
142negative regulation of fatty acid transport (GO:2000192)2.57811509
143vesicle coating (GO:0006901)2.55349869
144cellular protein complex localization (GO:0034629)2.54949890
145bile acid metabolic process (GO:0008206)2.54212381
146intestinal absorption (GO:0050892)2.54036933
147regulation of establishment of planar polarity (GO:0090175)2.53521003
148endothelial cell morphogenesis (GO:0001886)2.51976329
149positive regulation of triglyceride metabolic process (GO:0090208)2.51688984
150NADPH regeneration (GO:0006740)2.50879400
151tyrosine metabolic process (GO:0006570)2.50415301
152L-alpha-amino acid transmembrane transport (GO:1902475)2.50400742
153protein complex localization (GO:0031503)2.49255907
154polarized epithelial cell differentiation (GO:0030859)2.48601316
155macromolecular complex remodeling (GO:0034367)2.47448509
156plasma lipoprotein particle remodeling (GO:0034369)2.47448509
157protein-lipid complex remodeling (GO:0034368)2.47448509
158mannose metabolic process (GO:0006013)2.47322043
159regulation of hippo signaling (GO:0035330)2.45868386
160response to endoplasmic reticulum stress (GO:0034976)2.40861985
161hyaluronan catabolic process (GO:0030214)2.39165803
162response to laminar fluid shear stress (GO:0034616)2.38648753
163regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.36895138
164regulation of extracellular matrix disassembly (GO:0010715)2.35769468
165peptidyl-arginine omega-N-methylation (GO:0035247)2.32712968
166negative regulation of erythrocyte differentiation (GO:0045647)2.32591602
1673-UTR-mediated mRNA stabilization (GO:0070935)2.30129803
168insulin-like growth factor receptor signaling pathway (GO:0048009)2.29782261
169negative regulation of chondrocyte differentiation (GO:0032331)2.29693256
170response to epidermal growth factor (GO:0070849)2.28382006
171protein localization to microtubule (GO:0035372)2.27579123
172positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.25714690
173chromosome condensation (GO:0030261)2.25151130
174embryo implantation (GO:0007566)2.24277859

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.69224447
2RXR_22158963_ChIP-Seq_LIVER_Mouse3.96084971
3PPARA_22158963_ChIP-Seq_LIVER_Mouse3.77710762
4E2F7_22180533_ChIP-Seq_HELA_Human3.50160490
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.17710920
6LXR_22158963_ChIP-Seq_LIVER_Mouse3.17088377
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.13651871
8EGR1_19374776_ChIP-ChIP_THP-1_Human3.10492505
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.02789839
10CLOCK_20551151_ChIP-Seq_293T_Human2.89570859
11TP63_17297297_ChIP-ChIP_HaCaT_Human2.58048770
12STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.44909588
13MYC_22102868_ChIP-Seq_BL_Human2.44471083
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.17470468
15NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.08988258
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.96359664
17EGR1_23403033_ChIP-Seq_LIVER_Mouse1.91197158
18ESR1_15608294_ChIP-ChIP_MCF-7_Human1.90356259
19RARG_19884340_ChIP-ChIP_MEFs_Mouse1.90257636
20THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.88596683
21CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.86756161
22KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.74722710
23AR_21909140_ChIP-Seq_LNCAP_Human1.69229939
24TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64146056
25MYC_18555785_ChIP-Seq_MESCs_Mouse1.64091283
26FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.63666063
27TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.60702242
28HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.57243286
29ELK3_25401928_ChIP-Seq_HUVEC_Human1.54188422
30CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.54072119
31POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.53946855
32EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.53682387
33HIF1A_21447827_ChIP-Seq_MCF-7_Human1.50229988
34CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.49739817
35KDM2B_26808549_Chip-Seq_K562_Human1.47154909
36PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.46716711
37P300_27058665_Chip-Seq_ZR-75-30cells_Human1.45348504
38TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.44291837
39TCF7_22412390_ChIP-Seq_EML_Mouse1.43562962
40KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.41818364
41ATF3_27146783_Chip-Seq_COLON_Human1.41569348
42LXR_22292898_ChIP-Seq_THP-1_Human1.41080293
43* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39970017
44UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.39790979
45MYC_19079543_ChIP-ChIP_MESCs_Mouse1.39724796
46RACK7_27058665_Chip-Seq_MCF-7_Human1.39266645
47* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.38319399
48RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.38241375
49ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.37585694
50SOX2_27498859_Chip-Seq_STOMACH_Mouse1.37533556
51CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.37457616
52VDR_21846776_ChIP-Seq_THP-1_Human1.36571231
53SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.36335544
54KDM2B_26808549_Chip-Seq_DND41_Human1.36107589
55ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.34974379
56* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.34785989
57ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.34676613
58ZFP281_18757296_ChIP-ChIP_E14_Mouse1.33181122
59TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.32228170
60GATA6_25053715_ChIP-Seq_YYC3_Human1.30326508
61STAT3_1855785_ChIP-Seq_MESCs_Mouse1.28623219
62ZNF263_19887448_ChIP-Seq_K562_Human1.27795634
63* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.25886276
64CHD1_26751641_Chip-Seq_LNCaP_Human1.25489677
65ESR1_21235772_ChIP-Seq_MCF-7_Human1.25066260
66FOXO3_23340844_ChIP-Seq_DLD1_Human1.23935829
67TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.21590322
68NCOR1_26117541_ChIP-Seq_K562_Human1.21354769
69TCF3_18692474_ChIP-Seq_MEFs_Mouse1.21099646
70CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.21077443
71* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.20350618
72* FOXA2_19822575_ChIP-Seq_HepG2_Human1.20214766
73TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.19926484
74TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.19304905
75TP53_22127205_ChIP-Seq_IMR90_Human1.18412995
76NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.18323604
77UBF1/2_26484160_Chip-Seq_HMECs_Human1.17911504
78NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.16585580
79* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.16131071
80TRIM28_21343339_ChIP-Seq_HEK293_Human1.15941011
81STAT6_21828071_ChIP-Seq_BEAS2B_Human1.14434127
82TET1_21451524_ChIP-Seq_MESCs_Mouse1.14379395
83FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.14353239
84KDM2B_26808549_Chip-Seq_SUP-B15_Human1.13955838
85ESR2_21235772_ChIP-Seq_MCF-7_Human1.13886758
86* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.13400725
87CTCF_27219007_Chip-Seq_ERYTHROID_Human1.12815235
88ZFP281_27345836_Chip-Seq_ESCs_Mouse1.12283458
89NELFA_20434984_ChIP-Seq_ESCs_Mouse1.11430712
90DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.09892722
91* XRN2_22483619_ChIP-Seq_HELA_Human1.08938484
92FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.07705608
93* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.07343056
94GATA1_22025678_ChIP-Seq_K562_Human1.06539671
95ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.05911427
96ERG_21242973_ChIP-ChIP_JURKAT_Human1.05731125
97NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.05427323
98NANOG_18555785_ChIP-Seq_MESCs_Mouse1.04682382
99PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.04513634
100MYC_19030024_ChIP-ChIP_MESCs_Mouse1.04365255
101BRD4_27068464_Chip-Seq_AML-cells_Mouse1.03464845
102CREB1_26743006_Chip-Seq_LNCaP_Human1.02756441
103SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.01467380
104RUNX1_27514584_Chip-Seq_MCF-7_Human1.01402512
105KLF4_18555785_ChIP-Seq_MESCs_Mouse1.01339043
106SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.01255253
107SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.00927218
108NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.00564792
109TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.00560809
110KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.00293442
111UTX_26944678_Chip-Seq_JUKART_Human1.00120849
112WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.99896041
113SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.99645007
114SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.99456863
115SMC4_20622854_ChIP-Seq_HELA_Human0.99029589
116* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.98713342
117GATA4_25053715_ChIP-Seq_YYC3_Human0.98285224
118SRY_22984422_ChIP-ChIP_TESTIS_Rat0.97463990
119* P68_20966046_ChIP-Seq_HELA_Human0.96522240
120SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.96245108
121NFIB_24661679_ChIP-Seq_LUNG_Mouse0.94951845
122ZFX_18555785_ChIP-Seq_MESCs_Mouse0.94619057
123MAF_26560356_Chip-Seq_TH1_Human0.94515239
124SALL4_18804426_ChIP-ChIP_XEN_Mouse0.93769221
125CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.93003551
126DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.92082934
127* HNF4A_19822575_ChIP-Seq_HepG2_Human0.91582115
128SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.90990659
129FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.90301106
130TFEB_21752829_ChIP-Seq_HELA_Human0.89698711
131NANOG_21062744_ChIP-ChIP_HESCs_Human0.89589393
132KDM5A_27292631_Chip-Seq_BREAST_Human0.88610276
133TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.88516232
134KDM2B_26808549_Chip-Seq_JURKAT_Human0.87806716
135E2F1_21310950_ChIP-Seq_MCF-7_Human0.86621894
136EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.86618297

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.57538458
2MP0005360_urolithiasis4.52168138
3MP0002139_abnormal_hepatobiliary_system4.06243203
4MP0005365_abnormal_bile_salt2.99362194
5MP0003252_abnormal_bile_duct2.98307464
6MP0005085_abnormal_gallbladder_physiolo2.89436660
7MP0010352_gastrointestinal_tract_polyps2.49864738
8MP0005257_abnormal_intraocular_pressure2.45934302
9MP0003300_gastrointestinal_ulcer2.38422086
10MP0008438_abnormal_cutaneous_collagen2.36277990
11MP0010234_abnormal_vibrissa_follicle2.32729778
12MP0004858_abnormal_nervous_system2.32324391
13MP0005451_abnormal_body_composition2.25296813
14MP0003806_abnormal_nucleotide_metabolis2.14046532
15MP0003283_abnormal_digestive_organ2.06219931
16MP0009840_abnormal_foam_cell1.96293011
17MP0004233_abnormal_muscle_weight1.95959011
18MP0010329_abnormal_lipoprotein_level1.95080269
19MP0003566_abnormal_cell_adhesion1.81618398
20MP0008875_abnormal_xenobiotic_pharmacok1.80248986
21MP0005409_darkened_coat_color1.79144873
22MP0005076_abnormal_cell_differentiation1.78083680
23MP0002877_abnormal_melanocyte_morpholog1.75948902
24MP0004264_abnormal_extraembryonic_tissu1.73628672
25MP0009384_cardiac_valve_regurgitation1.71514867
26MP0001666_abnormal_nutrient_absorption1.71499470
27MP0003191_abnormal_cellular_cholesterol1.70614252
28MP0005083_abnormal_biliary_tract1.67238705
29MP0006054_spinal_hemorrhage1.66594608
30MP0009053_abnormal_anal_canal1.64738039
31MP0000537_abnormal_urethra_morphology1.62157108
32MP0004272_abnormal_basement_membrane1.59854582
33MP0009780_abnormal_chondrocyte_physiolo1.55526303
34MP0003111_abnormal_nucleus_morphology1.48873743
35MP0001348_abnormal_lacrimal_gland1.48076101
36MP0000609_abnormal_liver_physiology1.47715039
37MP0002796_impaired_skin_barrier1.46303560
38MP0005023_abnormal_wound_healing1.35945054
39MP0001849_ear_inflammation1.28344235
40MP0004197_abnormal_fetal_growth/weight/1.27791945
41MP0000858_altered_metastatic_potential1.27493288
42MP0005501_abnormal_skin_physiology1.26320850
43MP0005220_abnormal_exocrine_pancreas1.25398775
44MP0000566_synostosis1.24338908
45MP0005332_abnormal_amino_acid1.23261335
46MP0008260_abnormal_autophagy1.22874542
47MP0002089_abnormal_postnatal_growth/wei1.22358415
48MP0003941_abnormal_skin_development1.21030893
49MP0000678_abnormal_parathyroid_gland1.17481863
50MP0008961_abnormal_basal_metabolism1.16384989
51MP0004185_abnormal_adipocyte_glucose1.15995488
52MP0002896_abnormal_bone_mineralization1.15016807
53MP0010307_abnormal_tumor_latency1.13111283
54MP0009643_abnormal_urine_homeostasis1.12066341
55MP0000751_myopathy1.11814016
56MP0005621_abnormal_cell_physiology1.08776009
57MP0005275_abnormal_skin_tensile1.08004748
58MP0004782_abnormal_surfactant_physiolog1.07902800
59MP0001915_intracranial_hemorrhage1.07399749
60MP0008932_abnormal_embryonic_tissue1.06305107
61MP0003115_abnormal_respiratory_system1.06108748
62MP0005666_abnormal_adipose_tissue1.05990186
63MP0010030_abnormal_orbit_morphology1.05544121
64MP0000598_abnormal_liver_morphology1.04858662
65MP0002086_abnormal_extraembryonic_tissu1.04473033
66MP0003868_abnormal_feces_composition1.04323284
67MP0003385_abnormal_body_wall1.01863468
68MP0003045_fibrosis1.01752697
69MP0000767_abnormal_smooth_muscle1.01051981
70MP0001730_embryonic_growth_arrest1.00161991
71MP0002118_abnormal_lipid_homeostasis0.99325112
72MP0000762_abnormal_tongue_morphology0.99304176
73MP0004808_abnormal_hematopoietic_stem0.98972108
74MP0000467_abnormal_esophagus_morphology0.98756494
75MP0000579_abnormal_nail_morphology0.98303140
76MP0003693_abnormal_embryo_hatching0.96516571
77MP0002396_abnormal_hematopoietic_system0.95893353
78MP0005508_abnormal_skeleton_morphology0.94599263
79MP0003329_amyloid_beta_deposits0.94323415
80MP0009672_abnormal_birth_weight0.94136699
81MP0001216_abnormal_epidermal_layer0.93322957
82MP0003091_abnormal_cell_migration0.92706205
83MP0005623_abnormal_meninges_morphology0.92618631
84MP0002084_abnormal_developmental_patter0.92311817
85MP0002088_abnormal_embryonic_growth/wei0.91644079
86MP0005319_abnormal_enzyme/_coenzyme0.91632054
87MP0000428_abnormal_craniofacial_morphol0.90754696
88MP0000733_abnormal_muscle_development0.90487646
89MP0003984_embryonic_growth_retardation0.90439460
90MP0003123_paternal_imprinting0.89188312
91MP0003195_calcinosis0.88151094
92MP0002928_abnormal_bile_duct0.87967258
93MP0001672_abnormal_embryogenesis/_devel0.87853209
94MP0005380_embryogenesis_phenotype0.87853209
95MP0000462_abnormal_digestive_system0.87005320
96MP0003077_abnormal_cell_cycle0.86664306
97MP0010630_abnormal_cardiac_muscle0.84872078
98MP0002168_other_aberrant_phenotype0.84790595
99MP0002249_abnormal_larynx_morphology0.84708673
100MP0003942_abnormal_urinary_system0.84335209
101MP0010368_abnormal_lymphatic_system0.84302033
102MP0002138_abnormal_hepatobiliary_system0.83489040
103MP0003119_abnormal_digestive_system0.83426562
104MP0001243_abnormal_dermal_layer0.83388805
105MP0003279_aneurysm0.83345224
106MP0005375_adipose_tissue_phenotype0.82769134
107MP0002697_abnormal_eye_size0.81817670
108MP0002098_abnormal_vibrissa_morphology0.80987418
109MP0002092_abnormal_eye_morphology0.80446803
110MP0005248_abnormal_Harderian_gland0.80431824
111MP0001944_abnormal_pancreas_morphology0.80222552
112MP0000003_abnormal_adipose_tissue0.79129811
113MP0003172_abnormal_lysosome_physiology0.78509077
114MP0000627_abnormal_mammary_gland0.77555873
115MP0004019_abnormal_vitamin_homeostasis0.77301308
116MP0002085_abnormal_embryonic_tissue0.77137914
117MP0009931_abnormal_skin_appearance0.76616735
118MP0004947_skin_inflammation0.76550630
119MP0001697_abnormal_embryo_size0.76497274
120MP0002925_abnormal_cardiovascular_devel0.75976592
121MP0002254_reproductive_system_inflammat0.75356758
122MP0004957_abnormal_blastocyst_morpholog0.75144937
123MP0005384_cellular_phenotype0.74554539
124MP0009278_abnormal_bone_marrow0.73305655
125MP0002060_abnormal_skin_morphology0.72877976
126MP0003453_abnormal_keratinocyte_physiol0.72721595
127MP0002080_prenatal_lethality0.72471437
128MP0001661_extended_life_span0.71378380
129MP0009703_decreased_birth_body0.70649761
130MP0001958_emphysema0.70407030
131MP0005058_abnormal_lysosome_morphology0.69966372
132MP0005187_abnormal_penis_morphology0.69939910
133MP0002234_abnormal_pharynx_morphology0.69486531
134MP0000534_abnormal_ureter_morphology0.68731928
135MP0000350_abnormal_cell_proliferation0.67877609
136MP0002111_abnormal_tail_morphology0.66697731
137MP0002282_abnormal_trachea_morphology0.66026544
138MP0000477_abnormal_intestine_morphology0.65718186
139MP0005670_abnormal_white_adipose0.65285517
140MP0002932_abnormal_joint_morphology0.64436961
141MP0003567_abnormal_fetal_cardiomyocyte0.64176178
142MP0005503_abnormal_tendon_morphology0.63755686

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)4.41226022
2Intrahepatic cholestasis (HP:0001406)3.50742458
3Abnormality of monocarboxylic acid metabolism (HP:0010996)3.48286872
4Protrusio acetabuli (HP:0003179)3.38087709
5Cerebral aneurysm (HP:0004944)3.28356310
6Vertebral compression fractures (HP:0002953)3.19540433
7Xanthomatosis (HP:0000991)3.16508876
8Abnormality of the common coagulation pathway (HP:0010990)3.07391680
9Abnormality of the intrinsic pathway (HP:0010989)2.98633226
10Abnormality of aromatic amino acid family metabolism (HP:0004338)2.84861894
11Spastic diplegia (HP:0001264)2.76057339
12Hypobetalipoproteinemia (HP:0003563)2.73517645
13Complement deficiency (HP:0004431)2.68906752
14Broad face (HP:0000283)2.67698291
15Back pain (HP:0003418)2.65596986
16Pseudobulbar signs (HP:0002200)2.65495585
17Fragile skin (HP:0001030)2.61729589
18Aneurysm (HP:0002617)2.59079560
19Atrophic scars (HP:0001075)2.57333104
20Cervical subluxation (HP:0003308)2.54244794
21Shallow orbits (HP:0000586)2.50602649
22Hand muscle atrophy (HP:0009130)2.50505206
23Hypoglycemic coma (HP:0001325)2.50447148
24Ankle contracture (HP:0006466)2.50251791
25Abnormality of sulfur amino acid metabolism (HP:0004339)2.46218969
26Wormian bones (HP:0002645)2.45794843
27Arterial tortuosity (HP:0005116)2.45135127
28Insomnia (HP:0100785)2.42704498
29Premature rupture of membranes (HP:0001788)2.40583481
30Lymphangioma (HP:0100764)2.40028966
31Spinal rigidity (HP:0003306)2.38384250
32Asymmetry of the thorax (HP:0001555)2.38000443
33Achilles tendon contracture (HP:0001771)2.37126653
34Osteolytic defects of the phalanges of the hand (HP:0009771)2.36540812
35Osteolytic defects of the hand bones (HP:0009699)2.36540812
36Abnormality of glutamine family amino acid metabolism (HP:0010902)2.36098376
37Vascular tortuosity (HP:0004948)2.34183820
38Mitral valve prolapse (HP:0001634)2.33360742
39Abnormality of dentin (HP:0010299)2.33173315
40Ankyloglossia (HP:0010296)2.33106169
41Short nail (HP:0001799)2.31353610
42Biconcave vertebral bodies (HP:0004586)2.30235511
43Hypolipoproteinemia (HP:0010981)2.29106954
44Abnormality of oral frenula (HP:0000190)2.27767365
45Distal lower limb amyotrophy (HP:0008944)2.27368667
46Distal upper limb amyotrophy (HP:0007149)2.23693091
47Upper limb amyotrophy (HP:0009129)2.23693091
48Ulnar bowing (HP:0003031)2.21030473
49Hypoalphalipoproteinemia (HP:0003233)2.20642013
50Hyperacusis (HP:0010780)2.20575777
51Abnormal cartilage morphology (HP:0002763)2.19547900
52Increased connective tissue (HP:0009025)2.19257538
53Skin nodule (HP:0200036)2.18242514
54Abnormality of the Achilles tendon (HP:0005109)2.18115057
55Aortic aneurysm (HP:0004942)2.17485747
56Ketosis (HP:0001946)2.16505293
57Renovascular hypertension (HP:0100817)2.12397889
58Abnormality of complement system (HP:0005339)2.11741908
59Abnormality of the distal phalanges of the toes (HP:0010182)2.10839387
60Abnormality of the distal phalanx of the thumb (HP:0009617)2.09262595
61Long palpebral fissure (HP:0000637)2.07434600
62Hepatocellular carcinoma (HP:0001402)2.06459754
63Advanced eruption of teeth (HP:0006288)2.06099121
64Flat acetabular roof (HP:0003180)2.04206107
65Abnormality of the acetabulum (HP:0003170)2.03383905
66Prolonged partial thromboplastin time (HP:0003645)2.03092886
67Myocardial infarction (HP:0001658)2.02978807
68Peritonitis (HP:0002586)2.02664984
69Turricephaly (HP:0000262)2.02292136
70Elbow flexion contracture (HP:0002987)2.00412657
71Epidermoid cyst (HP:0200040)2.00320044
72Syringomyelia (HP:0003396)1.98768953
73Spinal cord lesions (HP:0100561)1.98768953
74Bowel diverticulosis (HP:0005222)1.98453697
75Trismus (HP:0000211)1.97832200
76Mitral regurgitation (HP:0001653)1.97521064
77Selective tooth agenesis (HP:0001592)1.97460590
78Bladder diverticulum (HP:0000015)1.95957279
79Natal tooth (HP:0000695)1.95691273
80Esophageal varix (HP:0002040)1.94062592
81Abnormality of endocrine pancreas physiology (HP:0012093)1.91814020
82Abnormality of the pancreatic islet cells (HP:0006476)1.91814020
83Renal duplication (HP:0000075)1.91363018
84Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.90110698
85Subacute progressive viral hepatitis (HP:0006572)1.89672806
86Abnormal ossification of hand bones (HP:0005921)1.89561182
87Ketoacidosis (HP:0001993)1.88991987
88Hypercholesterolemia (HP:0003124)1.88521278
89Joint laxity (HP:0001388)1.88457527
90Macroorchidism (HP:0000053)1.87301926
91Hyperammonemia (HP:0001987)1.87160869
92Dilatation of the ascending aorta (HP:0005111)1.87049225
93Mildly elevated creatine phosphokinase (HP:0008180)1.85630940
94Hypoglycemic seizures (HP:0002173)1.84204187
95Centrally nucleated skeletal muscle fibers (HP:0003687)1.83424687
96Metaphyseal cupping (HP:0003021)1.83314433
97Hyperlipoproteinemia (HP:0010980)1.82856503
98Long toe (HP:0010511)1.82808695
99Patellar dislocation (HP:0002999)1.82059690
100Abnormality of the calcaneus (HP:0008364)1.81867045
101Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.81746834
102Short 4th metacarpal (HP:0010044)1.81746834
103Vertebral clefting (HP:0008428)1.81095915
104Arnold-Chiari malformation (HP:0002308)1.80659830
105Increased variability in muscle fiber diameter (HP:0003557)1.80052361
106Camptodactyly of toe (HP:0001836)1.80040845
107Radial bowing (HP:0002986)1.79999723
108Hyperinsulinemic hypoglycemia (HP:0000825)1.79716477
109Abnormality of the 4th metacarpal (HP:0010012)1.79391784
110Exostoses (HP:0100777)1.79387902
111Abnormality of carpal bone ossification (HP:0006257)1.78931799
112Hyperextensible skin (HP:0000974)1.78181350
113Thin bony cortex (HP:0002753)1.77880478
114Abnormality of the lower motor neuron (HP:0002366)1.77713539
115Coxa vara (HP:0002812)1.77687946
116Breech presentation (HP:0001623)1.77349355
117Broad metatarsal (HP:0001783)1.76871373
118Elfin facies (HP:0004428)1.76681564
119Hyperglycinuria (HP:0003108)1.75700787
120Premature skin wrinkling (HP:0100678)1.75684958
121Abnormal delivery (HP:0001787)1.74662191
122Blue sclerae (HP:0000592)1.73336463
123Aortic dissection (HP:0002647)1.72954151
124Bowed forearm bones (HP:0003956)1.72175577
125Bowing of the arm (HP:0006488)1.72175577
126Mitral stenosis (HP:0001718)1.72005953
127Increased mean platelet volume (HP:0011877)1.71102320
128Hydroxyprolinuria (HP:0003080)1.70899380
129Abnormality of proline metabolism (HP:0010907)1.70899380
130Abnormality of glycine metabolism (HP:0010895)1.70669512
131Abnormality of serine family amino acid metabolism (HP:0010894)1.70669512
132Relative macrocephaly (HP:0004482)1.68955894
133Fat malabsorption (HP:0002630)1.68855046
134Soft skin (HP:0000977)1.68700079
135Overriding aorta (HP:0002623)1.68635529
136Ependymoma (HP:0002888)1.68587050
137Hallux valgus (HP:0001822)1.68247437
138Cupped ribs (HP:0000887)1.67977419
139Deviation of the thumb (HP:0009603)1.67933908
140Ectopia lentis (HP:0001083)1.66291000
141Deviation of the hallux (HP:0010051)1.66235400
142Abnormal foot bone ossification (HP:0010675)1.66235173
143Disproportionate tall stature (HP:0001519)1.65882484
144Hemorrhage of the eye (HP:0011885)1.65800829
145Glomerulosclerosis (HP:0000096)1.65448668
146Late onset (HP:0003584)1.64997875
147Focal segmental glomerulosclerosis (HP:0000097)1.64966945
148Abnormality of the thoracic spine (HP:0100711)1.64686456
149Neonatal short-limb short stature (HP:0008921)1.64095102
150Cholecystitis (HP:0001082)1.62960948
151Abnormal gallbladder physiology (HP:0012438)1.62960948
152Genu recurvatum (HP:0002816)1.62467168
153Rectal prolapse (HP:0002035)1.62177877
154Lower limb amyotrophy (HP:0007210)1.62136475
155Distal lower limb muscle weakness (HP:0009053)1.62107469
156Gout (HP:0001997)1.62083818
157Mucopolysacchariduria (HP:0008155)1.61731378
158Urinary glycosaminoglycan excretion (HP:0003541)1.61731378
159Insidious onset (HP:0003587)1.61633835
160Termporal pattern (HP:0011008)1.61633835
161Hyperglycinemia (HP:0002154)1.61127007
162Abnormality of skeletal muscle fiber size (HP:0012084)1.60126481
163Thin ribs (HP:0000883)1.59515189
164Dislocated radial head (HP:0003083)1.57709325
165Increased nuchal translucency (HP:0010880)1.57618616
166Delayed cranial suture closure (HP:0000270)1.57182207
167Reticulocytosis (HP:0001923)1.56220141

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.51228116
2PKN23.64800145
3SMG13.60961157
4ERN13.50878790
5EEF2K3.25171634
6SIK12.82063862
7CDK122.74278668
8PTK62.68959823
9MAP3K102.53581934
10PDGFRA2.36573685
11PRPF4B2.33073612
12IRAK32.31035353
13RIPK12.10437518
14LATS12.00862237
15FLT31.84962525
16FGFR41.84358399
17TAOK31.81380919
18TTN1.72121042
19PASK1.68479794
20EPHA21.65303779
21SCYL21.60345573
22BCKDK1.59268722
23EPHA31.51037641
24STK101.51012277
25DDR21.48796260
26PAK41.47249875
27LRRK21.45599081
28NME21.42616712
29MTOR1.39241826
30CDK61.30858198
31PTK21.28703018
32CAMK1D1.23265220
33LMTK21.19398312
34NEK11.16098311
35ICK1.13474963
36MET1.11059503
37NEK21.10904968
38PAK21.07957083
39ALK1.07405017
40RPS6KB21.02881243
41CDK41.02585386
42MAP3K81.01853264
43BMX1.01711418
44FRK0.99442195
45EPHB10.94862168
46STK30.94443726
47CDC70.90742624
48BRD40.89074175
49ERBB20.89024713
50FGFR10.85403790
51TAOK20.84909895
52ARAF0.84027479
53MAP3K130.83904407
54EPHB20.83626966
55PDGFRB0.81871986
56MAP3K70.81719683
57TGFBR10.80634365
58FGFR30.79699667
59TTK0.78851232
60CAMK1G0.77206544
61GRK60.77002424
62RET0.74951007
63PRKD20.73973638
64TGFBR20.73492184
65MAP3K20.69347222
66FGFR20.68900175
67MAP2K30.67832555
68KSR20.67155352
69EIF2AK10.66515256
70TYRO30.66273187
71NTRK10.66207608
72DYRK1B0.64726643
73LATS20.64486218
74MAPK110.63827319
75JAK20.62570895
76CLK10.60792046
77PRKCH0.59767380
78CDK80.58984523
79FER0.58720541
80JAK10.57279020
81MOS0.56947142
82GSK3A0.56422989
83RPS6KA40.55632124
84MST1R0.55398832
85CDK90.54837789
86PDPK10.53524915
87PRKD30.52438036
88BRAF0.52414769
89LIMK10.52357536
90MARK20.50467379
91MELK0.50015794
92MAP3K60.49205072
93MAP3K90.49117948
94MAP3K10.48700386
95PAK30.46485781
96NEK90.46429369
97MAP3K30.46099017
98ERBB40.45771122
99HIPK20.45655022
100STK380.45521815
101BRSK10.45426144
102CDK70.44662238
103JAK30.42613457
104TYK20.42381338
105RPS6KL10.41612237
106RPS6KC10.41612237
107TESK10.40666726
108CSK0.40295615
109CDC42BPA0.40067256
110PRKG20.39704427
111MAP2K20.39250286
112MAP3K140.39183368
113CHEK10.39174633
114AKT20.38199156
115INSRR0.38085618
116CHEK20.37896918
117TESK20.37764253
118CDK150.35790191
119CDK11A0.35673164
120RPS6KA20.35220479
121SIK30.35193244
122TRPM70.34931039
123ATR0.34465999
124AURKB0.34126113
125EGFR0.33441697
126ILK0.33018512
127KDR0.32016978
128CDK180.31946697
129PIM20.31359294
130CDK20.31287389
131INSR0.31224509
132MAPKAPK20.30787052
133ROCK20.30731796
134CSF1R0.30228790
135MAP2K10.29731019
136ITK0.29669724
137AURKA0.29540528

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.46797087
2Primary bile acid biosynthesis_Homo sapiens_hsa001202.90331303
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.83306698
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.60299446
5Arginine biosynthesis_Homo sapiens_hsa002202.29182955
6Other glycan degradation_Homo sapiens_hsa005112.27104331
7Tryptophan metabolism_Homo sapiens_hsa003802.18732815
8Selenocompound metabolism_Homo sapiens_hsa004502.11932706
9Complement and coagulation cascades_Homo sapiens_hsa046102.07446818
10Fatty acid degradation_Homo sapiens_hsa000712.04983407
11Maturity onset diabetes of the young_Homo sapiens_hsa049502.02793636
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.01446437
13One carbon pool by folate_Homo sapiens_hsa006701.93668812
14Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.91326018
15Lysine degradation_Homo sapiens_hsa003101.78074800
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.76317553
17Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.75469579
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.71647385
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.71642838
20PPAR signaling pathway_Homo sapiens_hsa033201.61621897
21* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.60002788
22Fatty acid metabolism_Homo sapiens_hsa012121.54323621
23Acute myeloid leukemia_Homo sapiens_hsa052211.52307576
24Bile secretion_Homo sapiens_hsa049761.47761353
25Pentose and glucuronate interconversions_Homo sapiens_hsa000401.47578205
26Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.47225868
27Biosynthesis of amino acids_Homo sapiens_hsa012301.43967318
28Caffeine metabolism_Homo sapiens_hsa002321.38487331
29Fat digestion and absorption_Homo sapiens_hsa049751.37891667
30Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.34902735
31Drug metabolism - other enzymes_Homo sapiens_hsa009831.34012461
32AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.31390476
33Thyroid hormone signaling pathway_Homo sapiens_hsa049191.30696247
34Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.20464907
35Carbon metabolism_Homo sapiens_hsa012001.20341070
36VEGF signaling pathway_Homo sapiens_hsa043701.20242612
37Butanoate metabolism_Homo sapiens_hsa006501.19690449
38Renal cell carcinoma_Homo sapiens_hsa052111.18485281
39Glioma_Homo sapiens_hsa052141.15368793
40DNA replication_Homo sapiens_hsa030301.15206822
41Propanoate metabolism_Homo sapiens_hsa006401.12428487
42Starch and sucrose metabolism_Homo sapiens_hsa005001.11913626
43Sulfur metabolism_Homo sapiens_hsa009201.11394982
44Bladder cancer_Homo sapiens_hsa052191.04766103
45Staphylococcus aureus infection_Homo sapiens_hsa051501.03063550
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.03045743
47Chemical carcinogenesis_Homo sapiens_hsa052041.02679638
48Insulin resistance_Homo sapiens_hsa049311.02040654
49ErbB signaling pathway_Homo sapiens_hsa040121.01932091
50Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.01876390
51Cell cycle_Homo sapiens_hsa041100.99283488
52ABC transporters_Homo sapiens_hsa020100.97765440
53Histidine metabolism_Homo sapiens_hsa003400.97104403
54Pyruvate metabolism_Homo sapiens_hsa006200.96636939
55Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.94078421
56Chronic myeloid leukemia_Homo sapiens_hsa052200.93946338
57Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.93168957
58ECM-receptor interaction_Homo sapiens_hsa045120.92758865
59Cyanoamino acid metabolism_Homo sapiens_hsa004600.92729681
60Neurotrophin signaling pathway_Homo sapiens_hsa047220.92339576
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.90858872
62Small cell lung cancer_Homo sapiens_hsa052220.89565853
63Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.89552539
64Colorectal cancer_Homo sapiens_hsa052100.89187252
65Peroxisome_Homo sapiens_hsa041460.88642519
66Phenylalanine metabolism_Homo sapiens_hsa003600.88463512
67Central carbon metabolism in cancer_Homo sapiens_hsa052300.88227854
68beta-Alanine metabolism_Homo sapiens_hsa004100.87449298
69Adherens junction_Homo sapiens_hsa045200.86667134
70Focal adhesion_Homo sapiens_hsa045100.86664908
71Cysteine and methionine metabolism_Homo sapiens_hsa002700.86180771
72Regulation of actin cytoskeleton_Homo sapiens_hsa048100.86120115
73Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.86037032
74Proteoglycans in cancer_Homo sapiens_hsa052050.85140327
75mTOR signaling pathway_Homo sapiens_hsa041500.83111621
76Vibrio cholerae infection_Homo sapiens_hsa051100.82161256
77Shigellosis_Homo sapiens_hsa051310.80838704
78Hepatitis B_Homo sapiens_hsa051610.80578684
79Glycosaminoglycan degradation_Homo sapiens_hsa005310.80535401
80Steroid hormone biosynthesis_Homo sapiens_hsa001400.80477407
81Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.79627090
82Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.78208747
83Retinol metabolism_Homo sapiens_hsa008300.77144581
84mRNA surveillance pathway_Homo sapiens_hsa030150.77100825
85Apoptosis_Homo sapiens_hsa042100.75858217
86Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.74791137
87Estrogen signaling pathway_Homo sapiens_hsa049150.73400332
88Fatty acid biosynthesis_Homo sapiens_hsa000610.73354445
89Tyrosine metabolism_Homo sapiens_hsa003500.72157977
90Pathways in cancer_Homo sapiens_hsa052000.71958117
91HTLV-I infection_Homo sapiens_hsa051660.71133925
92Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.70296753
93Protein digestion and absorption_Homo sapiens_hsa049740.69448469
94Hepatitis C_Homo sapiens_hsa051600.68764859
95PI3K-Akt signaling pathway_Homo sapiens_hsa041510.67924799
96Melanoma_Homo sapiens_hsa052180.67688976
97Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.67570821
98Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.65706627
99Choline metabolism in cancer_Homo sapiens_hsa052310.63887841
100Pentose phosphate pathway_Homo sapiens_hsa000300.63711189
101Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.63696511
102HIF-1 signaling pathway_Homo sapiens_hsa040660.63388351
103Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.63181233
104Prolactin signaling pathway_Homo sapiens_hsa049170.62509654
105Galactose metabolism_Homo sapiens_hsa000520.62103339
106MicroRNAs in cancer_Homo sapiens_hsa052060.62023928
107Lysosome_Homo sapiens_hsa041420.61462354
108Inositol phosphate metabolism_Homo sapiens_hsa005620.60783805
109AMPK signaling pathway_Homo sapiens_hsa041520.60616520
110Glycerolipid metabolism_Homo sapiens_hsa005610.60208947
111Vitamin digestion and absorption_Homo sapiens_hsa049770.59938329
112Endocytosis_Homo sapiens_hsa041440.59718315
113* N-Glycan biosynthesis_Homo sapiens_hsa005100.59383014
114Phospholipase D signaling pathway_Homo sapiens_hsa040720.59015675
115Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58268698
116Endometrial cancer_Homo sapiens_hsa052130.57895918
117Melanogenesis_Homo sapiens_hsa049160.57728001
118Tight junction_Homo sapiens_hsa045300.56421229
119Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.56194991
120Basal cell carcinoma_Homo sapiens_hsa052170.54977105
121Hippo signaling pathway_Homo sapiens_hsa043900.54398589
122Adipocytokine signaling pathway_Homo sapiens_hsa049200.53673409
123Amoebiasis_Homo sapiens_hsa051460.53010058
124GnRH signaling pathway_Homo sapiens_hsa049120.52855303
125Folate biosynthesis_Homo sapiens_hsa007900.52318433
126Arginine and proline metabolism_Homo sapiens_hsa003300.50861658
127B cell receptor signaling pathway_Homo sapiens_hsa046620.50700349
128Non-small cell lung cancer_Homo sapiens_hsa052230.49756086
129Pancreatic cancer_Homo sapiens_hsa052120.49421582
130Dilated cardiomyopathy_Homo sapiens_hsa054140.48374612
131Sphingolipid signaling pathway_Homo sapiens_hsa040710.47948053
132Prostate cancer_Homo sapiens_hsa052150.47887676
133Glucagon signaling pathway_Homo sapiens_hsa049220.47753636
134Spliceosome_Homo sapiens_hsa030400.46716159
135Base excision repair_Homo sapiens_hsa034100.46675256
136Thyroid cancer_Homo sapiens_hsa052160.46573984
137Notch signaling pathway_Homo sapiens_hsa043300.46041525
138Vitamin B6 metabolism_Homo sapiens_hsa007500.45742829
139Prion diseases_Homo sapiens_hsa050200.45433804
140Carbohydrate digestion and absorption_Homo sapiens_hsa049730.45144645
141Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.45080150
142Salmonella infection_Homo sapiens_hsa051320.44959523
143Thyroid hormone synthesis_Homo sapiens_hsa049180.43604090
144Fructose and mannose metabolism_Homo sapiens_hsa000510.42668197
145Antigen processing and presentation_Homo sapiens_hsa046120.42233283
146Insulin signaling pathway_Homo sapiens_hsa049100.41549383
147Leukocyte transendothelial migration_Homo sapiens_hsa046700.36693061
148Sulfur relay system_Homo sapiens_hsa041220.36658370
149Renin-angiotensin system_Homo sapiens_hsa046140.36439068
150Viral carcinogenesis_Homo sapiens_hsa052030.35563723
151Longevity regulating pathway - mammal_Homo sapiens_hsa042110.32629878

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