GANC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Glycosyl hydrolase enzymes hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. This gene encodes a member of glycosyl hydrolases family 31. This enzyme hydrolyses terminal, non-reducing 1,4-linked alpha-D-glucose residues and releases alpha-D-glucose. This is a key enzyme in glycogen metabolism and its gene localizes to a chromosomal region (15q15) that is associated with susceptibility to diabetes. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1daunorubicin metabolic process (GO:0044597)8.41072077
2polyketide metabolic process (GO:0030638)8.41072077
3doxorubicin metabolic process (GO:0044598)8.41072077
4aminoglycoside antibiotic metabolic process (GO:0030647)5.89813819
5coenzyme catabolic process (GO:0009109)5.49066067
6L-phenylalanine catabolic process (GO:0006559)5.11542439
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.11542439
8biotin metabolic process (GO:0006768)4.95804601
9erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.80500075
10L-phenylalanine metabolic process (GO:0006558)4.80500075
11valine metabolic process (GO:0006573)4.77151809
12aromatic amino acid family catabolic process (GO:0009074)4.69147286
13sulfur amino acid catabolic process (GO:0000098)4.65756847
14tryptophan catabolic process (GO:0006569)4.30889296
15indole-containing compound catabolic process (GO:0042436)4.30889296
16indolalkylamine catabolic process (GO:0046218)4.30889296
17cellular modified amino acid catabolic process (GO:0042219)4.27580801
18tryptophan metabolic process (GO:0006568)4.25025348
19behavioral response to nicotine (GO:0035095)4.23699874
20fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.08583804
21branched-chain amino acid catabolic process (GO:0009083)4.04516881
22hormone catabolic process (GO:0042447)3.94044061
23DNA deamination (GO:0045006)3.90565762
24branched-chain amino acid metabolic process (GO:0009081)3.85822284
25alpha-linolenic acid metabolic process (GO:0036109)3.81035514
26interkinetic nuclear migration (GO:0022027)3.76254874
27cytidine metabolic process (GO:0046087)3.74594540
28cytidine catabolic process (GO:0006216)3.74594540
29cytidine deamination (GO:0009972)3.74594540
30kynurenine metabolic process (GO:0070189)3.74132430
31cofactor catabolic process (GO:0051187)3.68350750
32fatty acid beta-oxidation (GO:0006635)3.67594696
33triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.65710842
34bile acid biosynthetic process (GO:0006699)3.63683020
35quinone metabolic process (GO:1901661)3.60885873
36glyoxylate metabolic process (GO:0046487)3.54109689
37response to dietary excess (GO:0002021)3.52120945
38epoxygenase P450 pathway (GO:0019373)3.50737862
39drug metabolic process (GO:0017144)3.49731147
40negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.48169362
41fatty acid oxidation (GO:0019395)3.47416490
42regulation of triglyceride catabolic process (GO:0010896)3.46739426
43regulation of sequestering of triglyceride (GO:0010889)3.42046776
44regulation of germinal center formation (GO:0002634)3.40138022
45lipid oxidation (GO:0034440)3.39703374
46positive regulation of oligodendrocyte differentiation (GO:0048714)3.39689715
47response to lipoprotein particle (GO:0055094)3.37479973
48positive regulation of fatty acid oxidation (GO:0046321)3.35811051
49aromatic amino acid family metabolic process (GO:0009072)3.34653249
50fatty acid catabolic process (GO:0009062)3.33229834
51amino-acid betaine metabolic process (GO:0006577)3.30364134
52urea metabolic process (GO:0019627)3.30164786
53urea cycle (GO:0000050)3.30164786
54cellular response to exogenous dsRNA (GO:0071360)3.29456929
55acylglycerol homeostasis (GO:0055090)3.29038845
56triglyceride homeostasis (GO:0070328)3.29038845
57tyrosine metabolic process (GO:0006570)3.28845927
58bile acid metabolic process (GO:0008206)3.27079252
59short-chain fatty acid metabolic process (GO:0046459)3.23965391
60phenol-containing compound catabolic process (GO:0019336)3.23597168
61indolalkylamine metabolic process (GO:0006586)3.22874005
62cellular biogenic amine catabolic process (GO:0042402)3.22604614
63amine catabolic process (GO:0009310)3.22604614
64cysteine metabolic process (GO:0006534)3.21937121
65interferon-gamma production (GO:0032609)3.21611085
66pyrimidine ribonucleoside catabolic process (GO:0046133)3.19150587
67cellular amino acid catabolic process (GO:0009063)3.16180060
68alpha-amino acid catabolic process (GO:1901606)3.13659878
69complement activation, alternative pathway (GO:0006957)3.13502540
70somite development (GO:0061053)3.13111154
71epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.12081721
72sulfation (GO:0051923)3.10022447
73heme transport (GO:0015886)3.09514447
74nucleoside transmembrane transport (GO:1901642)3.07980590
75monocarboxylic acid catabolic process (GO:0072329)3.07611500
76negative regulation of lipase activity (GO:0060192)3.07260445
77nitrogen cycle metabolic process (GO:0071941)3.06396944
78protein carboxylation (GO:0018214)3.06295879
79peptidyl-glutamic acid carboxylation (GO:0017187)3.06295879
80negative regulation of mast cell activation (GO:0033004)3.05642446
81organic acid catabolic process (GO:0016054)3.05061403
82carboxylic acid catabolic process (GO:0046395)3.05061403
83positive regulation of gamma-delta T cell activation (GO:0046645)3.02204534
84somite rostral/caudal axis specification (GO:0032525)3.01408298
85positive regulation of fatty acid beta-oxidation (GO:0032000)2.98987598
86primary alcohol catabolic process (GO:0034310)2.98658315
87activated T cell proliferation (GO:0050798)2.98088579
88maintenance of protein location in nucleus (GO:0051457)2.93826326
89carnitine metabolic process (GO:0009437)2.93384022
90acetyl-CoA metabolic process (GO:0006084)2.93328737
91regulation of protein activation cascade (GO:2000257)2.90530020
92prostate gland growth (GO:0060736)2.90297266
93homocysteine metabolic process (GO:0050667)2.87303725
94flavonoid metabolic process (GO:0009812)2.86105691
95pyrimidine nucleoside catabolic process (GO:0046135)2.84363625
96phenylpropanoid metabolic process (GO:0009698)2.84271286
97protein polyglutamylation (GO:0018095)2.83924639
98positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.83724092
99diterpenoid biosynthetic process (GO:0016102)2.82107930
100piRNA metabolic process (GO:0034587)2.81781431
101serine family amino acid catabolic process (GO:0009071)2.80347040
102detection of light stimulus involved in sensory perception (GO:0050962)2.79958041
103detection of light stimulus involved in visual perception (GO:0050908)2.79958041
104omega-hydroxylase P450 pathway (GO:0097267)2.79647761
105regulation of MHC class I biosynthetic process (GO:0045343)2.79582491
106xenobiotic catabolic process (GO:0042178)2.79581688
107fatty acid transmembrane transport (GO:1902001)2.79260135
108very long-chain fatty acid metabolic process (GO:0000038)2.76897566
109cellular ketone metabolic process (GO:0042180)2.76588325
110imidazole-containing compound metabolic process (GO:0052803)2.76285396
111drug transmembrane transport (GO:0006855)2.75611270
112positive regulation of defense response to virus by host (GO:0002230)2.75441196
113lysine catabolic process (GO:0006554)2.75214150
114lysine metabolic process (GO:0006553)2.75214150
115high-density lipoprotein particle remodeling (GO:0034375)2.75076248
116plasma lipoprotein particle clearance (GO:0034381)2.73557691
117L-fucose catabolic process (GO:0042355)2.73511005
118fucose catabolic process (GO:0019317)2.73511005
119L-fucose metabolic process (GO:0042354)2.73511005
120endoderm formation (GO:0001706)2.72810781
121regulation of MHC class II biosynthetic process (GO:0045346)2.71815437
122negative regulation of systemic arterial blood pressure (GO:0003085)2.70570682
123regulation of B cell receptor signaling pathway (GO:0050855)2.70174298
124transepithelial transport (GO:0070633)2.69978569
125regulation of complement activation (GO:0030449)2.69929070
126phospholipid efflux (GO:0033700)2.69118477
127mitochondrial respiratory chain complex I assembly (GO:0032981)2.68274087
128NADH dehydrogenase complex assembly (GO:0010257)2.68274087
129mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.68274087
130bile acid and bile salt transport (GO:0015721)2.67019036
131ethanol oxidation (GO:0006069)2.66952389
132positive regulation of lipid catabolic process (GO:0050996)2.66949608
133positive regulation of granulocyte differentiation (GO:0030854)2.62986154
134branching involved in labyrinthine layer morphogenesis (GO:0060670)2.61614771
135DNA methylation involved in gamete generation (GO:0043046)2.61157892
136neutrophil mediated immunity (GO:0002446)2.58892136
137cell proliferation in forebrain (GO:0021846)2.58435468
138response to caffeine (GO:0031000)2.56695511
139cellular response to ATP (GO:0071318)2.56044553
140purinergic nucleotide receptor signaling pathway (GO:0035590)2.55112842
141rRNA catabolic process (GO:0016075)2.53691153
142adaptation of signaling pathway (GO:0023058)2.52467683
143B cell receptor signaling pathway (GO:0050853)2.52269299
144phosphatidylethanolamine metabolic process (GO:0046337)2.52152019
145positive regulation of glomerulus development (GO:0090193)2.49479153
146indole-containing compound metabolic process (GO:0042430)2.47434517
147preassembly of GPI anchor in ER membrane (GO:0016254)2.47078136
148negative regulation of cAMP-mediated signaling (GO:0043951)2.46883006
149phosphatidylinositol acyl-chain remodeling (GO:0036149)2.42876853
1503-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.42467225
151purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.42467225
152negative regulation of lipid storage (GO:0010888)2.41633517
153cellular extravasation (GO:0045123)2.41487110
154regulation of memory T cell differentiation (GO:0043380)2.40653020
155negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.40538205
156negative regulation of T-helper cell differentiation (GO:0045623)2.40538205
157regulation of skeletal muscle contraction (GO:0014819)2.40228002
158microglial cell activation (GO:0001774)2.38819937
159regulation of gamma-delta T cell activation (GO:0046643)2.37652348
160drug catabolic process (GO:0042737)2.35924064
161platelet dense granule organization (GO:0060155)2.35516961
162cell wall macromolecule catabolic process (GO:0016998)2.34452341
163synapsis (GO:0007129)2.33894798
164positive regulation of mast cell activation (GO:0033005)2.33848601
165parturition (GO:0007567)2.33007873
166regulation of female receptivity (GO:0045924)2.32267536
167regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.32227157
168negative thymic T cell selection (GO:0045060)2.31550029
169regulation of mast cell activation (GO:0033003)2.31379556
170cardiovascular system development (GO:0072358)2.30761664
171negative T cell selection (GO:0043383)2.28707972
172phosphatidylethanolamine biosynthetic process (GO:0006646)2.25332654
173regulation of gamma-delta T cell differentiation (GO:0045586)2.22215624
174positive regulation of fatty acid transport (GO:2000193)2.21196177
175epithelial cilium movement (GO:0003351)2.21191277
176negative regulation of acute inflammatory response (GO:0002674)2.21176648
177cellular response to lithium ion (GO:0071285)2.21026978
178cAMP catabolic process (GO:0006198)2.20869198
179positive regulation of cAMP-mediated signaling (GO:0043950)2.20768486
180establishment of protein localization to Golgi (GO:0072600)2.20624371
181positive regulation of phosphatase activity (GO:0010922)2.19885109
182regulation of rhodopsin mediated signaling pathway (GO:0022400)2.17709396
183multicellular organism reproduction (GO:0032504)2.17660732
184regulation of hippo signaling (GO:0035330)2.17512039
185positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.16510974

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human7.73376327
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.17898907
3RXR_22158963_ChIP-Seq_LIVER_Mouse4.90689260
4EGR1_23403033_ChIP-Seq_LIVER_Mouse4.78992840
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.47594095
6PPARA_22158963_ChIP-Seq_LIVER_Mouse4.12325604
7LXR_22158963_ChIP-Seq_LIVER_Mouse4.09293325
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.48021445
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.99087966
10KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.87012776
11KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.87012776
12KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.87012776
13CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.72533265
14GBX2_23144817_ChIP-Seq_PC3_Human2.66552899
15* IRF8_22096565_ChIP-ChIP_GC-B_Human2.64000337
16FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.58197224
17CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.47370302
18ZNF274_21170338_ChIP-Seq_K562_Hela2.44280297
19EZH2_22144423_ChIP-Seq_EOC_Human2.37671648
20IRF1_19129219_ChIP-ChIP_H3396_Human2.17312515
21ZFP57_27257070_Chip-Seq_ESCs_Mouse2.16790489
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.13094362
23IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.09511391
24SCL_19346495_ChIP-Seq_HPC-7_Human2.09401363
25GATA1_22025678_ChIP-Seq_K562_Human2.09284635
26CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.06814817
27GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.06344774
28STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.89466387
29* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.86207370
30TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.80708244
31ER_23166858_ChIP-Seq_MCF-7_Human1.79581332
32* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.72715790
33* IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.63395114
34SMAD_19615063_ChIP-ChIP_OVARY_Human1.58659816
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.54954967
36NOTCH1_21737748_ChIP-Seq_TLL_Human1.53620268
37P300_19829295_ChIP-Seq_ESCs_Human1.52936281
38FUS_26573619_Chip-Seq_HEK293_Human1.51512648
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.51066463
40STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.49469334
41SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.48105266
42TP63_19390658_ChIP-ChIP_HaCaT_Human1.47645301
43UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.47416133
44BCAT_22108803_ChIP-Seq_LS180_Human1.46499082
45GATA2_21666600_ChIP-Seq_HMVEC_Human1.44967304
46PCGF2_27294783_Chip-Seq_NPCs_Mouse1.44887496
47STAT3_23295773_ChIP-Seq_U87_Human1.44745944
48SMAD4_21799915_ChIP-Seq_A2780_Human1.43410129
49* TCF4_23295773_ChIP-Seq_U87_Human1.43335501
50LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.42926453
51FLI1_27457419_Chip-Seq_LIVER_Mouse1.40801972
52NR3C1_21868756_ChIP-Seq_MCF10A_Human1.40255825
53EWS_26573619_Chip-Seq_HEK293_Human1.39392650
54PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.38927028
55EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.38795879
56GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.37437180
57PCGF2_27294783_Chip-Seq_ESCs_Mouse1.37085395
58Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.36073223
59PRDM14_20953172_ChIP-Seq_ESCs_Human1.35266143
60BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.35095777
61EZH2_27294783_Chip-Seq_NPCs_Mouse1.31803821
62TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30347434
63MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.29891490
64STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.28291125
65IGF1R_20145208_ChIP-Seq_DFB_Human1.27478017
66CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.25676898
67AR_25329375_ChIP-Seq_VCAP_Human1.24944825
68CBP_20019798_ChIP-Seq_JUKART_Human1.23834163
69IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.23834163
70CDX2_22108803_ChIP-Seq_LS180_Human1.22391564
71HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.20939570
72ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.20554294
73AHR_22903824_ChIP-Seq_MCF-7_Human1.20155896
74VDR_24787735_ChIP-Seq_THP-1_Human1.18894757
75TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.18359961
76CDX2_20551321_ChIP-Seq_CACO-2_Human1.18242179
77AR_21572438_ChIP-Seq_LNCaP_Human1.18115690
78SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.17388050
79ARNT_22903824_ChIP-Seq_MCF-7_Human1.17094413
80IRF8_27001747_Chip-Seq_BMDM_Mouse1.15753137
81PIAS1_25552417_ChIP-Seq_VCAP_Human1.15371401
82BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.14772459
83BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.12029696
84FLI1_21867929_ChIP-Seq_TH2_Mouse1.11413481
85POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10233197
86TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10233197
87CRX_20693478_ChIP-Seq_RETINA_Mouse1.10082582
88SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.09489847
89SMRT_27268052_Chip-Seq_Bcells_Human1.09348589
90TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08720845
91TAF15_26573619_Chip-Seq_HEK293_Human1.08708289
92IRF8_21731497_ChIP-ChIP_J774_Mouse1.08605545
93SOX2_19829295_ChIP-Seq_ESCs_Human1.07925085
94NANOG_19829295_ChIP-Seq_ESCs_Human1.07925085
95TP53_16413492_ChIP-PET_HCT116_Human1.07769238
96GATA3_21878914_ChIP-Seq_MCF-7_Human1.07578032
97TOP2B_26459242_ChIP-Seq_MCF-7_Human1.07521850
98AUTS2_25519132_ChIP-Seq_293T-REX_Human1.06747182
99LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.06747016
100BMI1_23680149_ChIP-Seq_NPCS_Mouse1.06341838
101RUNX_20019798_ChIP-Seq_JUKART_Human1.06136737
102VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.05977412
103NANOG_18555785_Chip-Seq_ESCs_Mouse1.05756086
104SMAD4_21741376_ChIP-Seq_EPCs_Human1.05572778
105MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.05546025
106KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05366430
107FOXA1_27270436_Chip-Seq_PROSTATE_Human1.05096486
108FOXA1_25329375_ChIP-Seq_VCAP_Human1.05096486
109RUNX2_22187159_ChIP-Seq_PCA_Human1.04177789
110GATA3_27048872_Chip-Seq_THYMUS_Human1.04087462
111TCF4_22108803_ChIP-Seq_LS180_Human1.03695306
112SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.03690713
113EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03583953
114P53_22387025_ChIP-Seq_ESCs_Mouse1.02851448
115SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.02143978
116FOXA1_21572438_ChIP-Seq_LNCaP_Human1.02014454
117CDX2_19796622_ChIP-Seq_MESCs_Mouse1.01974748
118PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00990895
119PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.00925776
120OCT4_21477851_ChIP-Seq_ESCs_Mouse1.00921844
121GATA4_25053715_ChIP-Seq_YYC3_Human1.00435055
122KAP1_22055183_ChIP-Seq_ESCs_Mouse0.98903738
123* FOXA2_19822575_ChIP-Seq_HepG2_Human0.98036449
124SUZ12_27294783_Chip-Seq_NPCs_Mouse0.97421941
125FOXO3_23340844_ChIP-Seq_DLD1_Human0.95919608
126HTT_18923047_ChIP-ChIP_STHdh_Human0.93972696
127ESET_19884257_ChIP-Seq_ESCs_Mouse0.92987560
128RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.91165431
129RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91088267
130PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.90959069
131TCF3_18692474_ChIP-Seq_MESCs_Mouse0.90451367
132FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.89394412
133* HNF4A_19822575_ChIP-Seq_HepG2_Human0.89057073
134NFE2_27457419_Chip-Seq_LIVER_Mouse0.88197619
135PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87565501
136GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.87485162
137RXRA_24833708_ChIP-Seq_LIVER_Mouse0.87272315
138RUNX1_27457419_Chip-Seq_LIVER_Mouse0.86296477
139ESR1_20079471_ChIP-ChIP_T-47D_Human0.84719116
140CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84567823
141* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.84249761
142* SMAD1_18555785_Chip-Seq_ESCs_Mouse0.83989659
143FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.83290027
144NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.81587395
145AR_20517297_ChIP-Seq_VCAP_Human0.77808701
146FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.76852104
147SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.75931443
148* ZFX_18555785_Chip-Seq_ESCs_Mouse0.75417999
149PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.75405478
150NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.75062982
151PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.74671180
152VDR_22108803_ChIP-Seq_LS180_Human0.74225412
153MYB_26560356_Chip-Seq_TH1_Human0.73877946
154* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.73263694
155ESR1_21235772_ChIP-Seq_MCF-7_Human0.72667322
156RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.71787485
157GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.71650107
158* FOXA1_25552417_ChIP-Seq_VCAP_Human0.71522032
159* ESRRB_18555785_Chip-Seq_ESCs_Mouse0.71384029
160SOX2_27498859_Chip-Seq_STOMACH_Mouse0.69788735
161NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.69630312
162FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.69153147
163EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.68890018
164* OCT4_18555785_Chip-Seq_ESCs_Mouse0.68313107
165STAT3_18555785_Chip-Seq_ESCs_Mouse0.68118229
166GATA3_26560356_Chip-Seq_TH2_Human0.66952697
167KLF4_18555785_Chip-Seq_ESCs_Mouse0.66767602
168TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.66641058
169LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.65850553
170SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.64248260
171ESR2_21235772_ChIP-Seq_MCF-7_Human0.64072845
172CSB_26484114_Chip-Seq_FIBROBLAST_Human0.63831277
173TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.63742360
174E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.63665394
175NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.63508240
176PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.63238941

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.09101928
2MP0005360_urolithiasis4.44274445
3MP0005365_abnormal_bile_salt4.39604780
4MP0003011_delayed_dark_adaptation4.24265415
5MP0005085_abnormal_gallbladder_physiolo3.88008426
6MP0003646_muscle_fatigue3.70718862
7MP0000569_abnormal_digit_pigmentation3.55377854
8MP0008875_abnormal_xenobiotic_pharmacok3.29474920
9MP0002254_reproductive_system_inflammat3.26980630
10MP0003252_abnormal_bile_duct2.81192877
11MP0010329_abnormal_lipoprotein_level2.52049224
12MP0005075_abnormal_melanosome_morpholog2.45961156
13MP0005670_abnormal_white_adipose2.43185303
14MP0006292_abnormal_olfactory_placode2.43126569
15MP0005174_abnormal_tail_pigmentation2.42436584
16MP0008877_abnormal_DNA_methylation2.40608799
17MP0002102_abnormal_ear_morphology2.37957636
18MP0005646_abnormal_pituitary_gland2.34729428
19MP0003806_abnormal_nucleotide_metabolis2.32771299
20MP0004264_abnormal_extraembryonic_tissu2.28874372
21MP0000015_abnormal_ear_pigmentation2.17769380
22MP0004145_abnormal_muscle_electrophysio2.04254338
23MP0000013_abnormal_adipose_tissue1.92553396
24MP0005332_abnormal_amino_acid1.91873468
25MP0000609_abnormal_liver_physiology1.90689136
26MP0005451_abnormal_body_composition1.90565885
27MP0003183_abnormal_peptide_metabolism1.84152798
28MP0002118_abnormal_lipid_homeostasis1.76450415
29MP0004381_abnormal_hair_follicle1.67250938
30MP0003195_calcinosis1.67072113
31MP0001485_abnormal_pinna_reflex1.65690528
32MP0004019_abnormal_vitamin_homeostasis1.63080295
33MP0003191_abnormal_cellular_cholesterol1.62446898
34MP0005319_abnormal_enzyme/_coenzyme1.61066336
35MP0001666_abnormal_nutrient_absorption1.60292877
36MP0004043_abnormal_pH_regulation1.58068324
37MP0003186_abnormal_redox_activity1.54736112
38MP0005666_abnormal_adipose_tissue1.52878590
39MP0002452_abnormal_antigen_presenting1.50199724
40MP0003868_abnormal_feces_composition1.49889846
41MP0002138_abnormal_hepatobiliary_system1.47504939
42MP0000372_irregular_coat_pigmentation1.45559377
43MP0004142_abnormal_muscle_tone1.41364165
44MP0000230_abnormal_systemic_arterial1.41021900
45MP0005551_abnormal_eye_electrophysiolog1.37308341
46MP0002332_abnormal_exercise_endurance1.37303112
47MP0006082_CNS_inflammation1.36956976
48MP0003172_abnormal_lysosome_physiology1.35529686
49MP0002876_abnormal_thyroid_physiology1.35501273
50MP0002971_abnormal_brown_adipose1.32947292
51MP0001764_abnormal_homeostasis1.32097093
52MP0005389_reproductive_system_phenotype1.31790538
53MP0001835_abnormal_antigen_presentation1.30897558
54MP0006035_abnormal_mitochondrial_morpho1.29536670
55MP0004185_abnormal_adipocyte_glucose1.29491025
56MP0006036_abnormal_mitochondrial_physio1.29153815
57MP0000383_abnormal_hair_follicle1.28950608
58MP0005387_immune_system_phenotype1.28832069
59MP0001790_abnormal_immune_system1.28832069
60MP0008872_abnormal_physiological_respon1.27438789
61MP0000678_abnormal_parathyroid_gland1.27253300
62MP0002160_abnormal_reproductive_system1.26870591
63MP0005584_abnormal_enzyme/coenzyme_acti1.24896720
64MP0009697_abnormal_copulation1.24709466
65MP0002420_abnormal_adaptive_immunity1.24532325
66MP0009643_abnormal_urine_homeostasis1.23478944
67MP0001819_abnormal_immune_cell1.22999294
68MP0010386_abnormal_urinary_bladder1.21921755
69MP0002095_abnormal_skin_pigmentation1.21527576
70MP0002970_abnormal_white_adipose1.20787053
71MP0002277_abnormal_respiratory_mucosa1.20202238
72MP0005464_abnormal_platelet_physiology1.18336255
73MP0003724_increased_susceptibility_to1.16946586
74MP0002132_abnormal_respiratory_system1.14938051
75MP0001661_extended_life_span1.14161305
76MP0010368_abnormal_lymphatic_system1.14132537
77MP0003879_abnormal_hair_cell1.13986124
78MP0005083_abnormal_biliary_tract1.11917896
79MP0002419_abnormal_innate_immunity1.11857470
80MP0005334_abnormal_fat_pad1.10874986
81MP0003890_abnormal_embryonic-extraembry1.10186699
82MP0005671_abnormal_response_to1.09165608
83MP0004130_abnormal_muscle_cell1.08762876
84MP0009115_abnormal_fat_cell1.07345814
85MP0002148_abnormal_hypersensitivity_rea1.07310155
86MP0003950_abnormal_plasma_membrane1.05965764
87MP0001800_abnormal_humoral_immune1.02298497
88MP0000685_abnormal_immune_system1.01985136
89MP0002638_abnormal_pupillary_reflex1.01232823
90MP0002396_abnormal_hematopoietic_system1.00285409
91MP0008775_abnormal_heart_ventricle0.99908631
92MP0006072_abnormal_retinal_apoptosis0.99449161
93MP0005647_abnormal_sex_gland0.97555100
94MP0004484_altered_response_of0.97373698
95MP0003045_fibrosis0.97241608
96MP0008004_abnormal_stomach_pH0.96711053
97MP0005167_abnormal_blood-brain_barrier0.96073352
98MP0009764_decreased_sensitivity_to0.95600271
99MP0002078_abnormal_glucose_homeostasis0.94962442
100MP0008469_abnormal_protein_level0.92196755
101MP0000598_abnormal_liver_morphology0.91128719
102MP0003763_abnormal_thymus_physiology0.90785826
103MP0005253_abnormal_eye_physiology0.90665823
104MP0009763_increased_sensitivity_to0.88343443
105MP0000689_abnormal_spleen_morphology0.87546149
106MP0000516_abnormal_urinary_system0.85407117
107MP0005367_renal/urinary_system_phenotyp0.85407117
108MP0000749_muscle_degeneration0.85106763
109MP0000716_abnormal_immune_system0.84062797
110MP0004782_abnormal_surfactant_physiolog0.83268543
111MP0009046_muscle_twitch0.81527541
112MP0001986_abnormal_taste_sensitivity0.81082070
113MP0002405_respiratory_system_inflammati0.80464209
114MP0001845_abnormal_inflammatory_respons0.80157102
115MP0005266_abnormal_metabolism0.80068871
116MP0000427_abnormal_hair_cycle0.80001594
117MP0005375_adipose_tissue_phenotype0.79956846
118MP0001501_abnormal_sleep_pattern0.79400567
119MP0002837_dystrophic_cardiac_calcinosis0.78441698
120MP0004885_abnormal_endolymph0.77307229
121MP0005257_abnormal_intraocular_pressure0.77192777
122MP0000631_abnormal_neuroendocrine_gland0.76702088
123MP0008961_abnormal_basal_metabolism0.76526419
124MP0003656_abnormal_erythrocyte_physiolo0.75808380
125MP0005410_abnormal_fertilization0.75062389
126MP0005379_endocrine/exocrine_gland_phen0.74034195
127MP0001533_abnormal_skeleton_physiology0.73725870
128MP0005025_abnormal_response_to0.73552739
129MP0003787_abnormal_imprinting0.73358853
130MP0000470_abnormal_stomach_morphology0.72467797
131MP0003828_pulmonary_edema0.72462677
132MP0005376_homeostasis/metabolism_phenot0.72276959
133MP0001440_abnormal_grooming_behavior0.71237275
134MP0004036_abnormal_muscle_relaxation0.71115274
135MP0002398_abnormal_bone_marrow0.70928945
136MP0005535_abnormal_body_temperature0.69776711
137MP0001853_heart_inflammation0.69310411
138MP0004084_abnormal_cardiac_muscle0.68187465
139MP0009785_altered_susceptibility_to0.68088349
140MP0008995_early_reproductive_senescence0.67290862
141MP0005645_abnormal_hypothalamus_physiol0.66977553
142MP0002098_abnormal_vibrissa_morphology0.66877757
143MP0005000_abnormal_immune_tolerance0.65670832
144MP0009765_abnormal_xenobiotic_induced0.65540133
145MP0009840_abnormal_foam_cell0.65523902
146MP0002723_abnormal_immune_serum0.65454889
147MP0002127_abnormal_cardiovascular_syste0.65274124
148MP0005636_abnormal_mineral_homeostasis0.64598108
149MP0001968_abnormal_touch/_nociception0.64052227
150MP0002166_altered_tumor_susceptibility0.63864196
151MP0005310_abnormal_salivary_gland0.63820229
152MP0004147_increased_porphyrin_level0.63788517
153MP0009053_abnormal_anal_canal0.63626605
154MP0009642_abnormal_blood_homeostasis0.62887184
155MP0002928_abnormal_bile_duct0.62213545
156MP0000465_gastrointestinal_hemorrhage0.61766736
157MP0005499_abnormal_olfactory_system0.60767721
158MP0005394_taste/olfaction_phenotype0.60767721
159MP0005452_abnormal_adipose_tissue0.60332419
160MP0001243_abnormal_dermal_layer0.58595356
161MP0001324_abnormal_eye_pigmentation0.58060585
162MP0005448_abnormal_energy_balance0.58032399

Predicted human phenotypes

RankGene SetZ-score
1Hypochromic microcytic anemia (HP:0004840)5.46268923
2Hyperinsulinemic hypoglycemia (HP:0000825)4.62770680
3Abnormality of aromatic amino acid family metabolism (HP:0004338)4.55342640
4Intrahepatic cholestasis (HP:0001406)4.39468902
5Hyperglycinuria (HP:0003108)4.31711613
6Abnormality of the intrinsic pathway (HP:0010989)3.96740368
7Prolonged partial thromboplastin time (HP:0003645)3.82360503
8Abnormality of glycine metabolism (HP:0010895)3.75216529
9Abnormality of serine family amino acid metabolism (HP:0010894)3.75216529
10Hypoglycemic coma (HP:0001325)3.70728315
11Short 1st metacarpal (HP:0010034)3.70456778
12Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)3.70456778
13Pancreatic cysts (HP:0001737)3.54788157
14Xanthomatosis (HP:0000991)3.54577330
15Ketosis (HP:0001946)3.53606667
16Reduced antithrombin III activity (HP:0001976)3.45429047
17Joint hemorrhage (HP:0005261)3.42262226
18Bilateral microphthalmos (HP:0007633)3.41311404
19Ketoacidosis (HP:0001993)3.40765161
20Congenital sensorineural hearing impairment (HP:0008527)3.38782251
21Hyperammonemia (HP:0001987)3.34659195
22Deep venous thrombosis (HP:0002625)3.32037018
23Congenital stationary night blindness (HP:0007642)3.28503942
24Abnormality of the 1st metacarpal (HP:0010009)3.18242382
25Abnormality of monocarboxylic acid metabolism (HP:0010996)3.13098982
26Renal cortical cysts (HP:0000803)3.11547035
27Hyperlipoproteinemia (HP:0010980)3.11365987
28Abnormality of dicarboxylic acid metabolism (HP:0010995)3.05631061
29Dicarboxylic aciduria (HP:0003215)3.05631061
30Abnormality of the renal cortex (HP:0011035)3.01119517
31Abnormality of the renal collecting system (HP:0004742)3.00859034
32Pancreatic fibrosis (HP:0100732)2.98867354
33Hepatoblastoma (HP:0002884)2.97697040
34Abnormality of the nasal septum (HP:0000419)2.94332259
35Keratoconus (HP:0000563)2.90607744
36Increased corneal curvature (HP:0100692)2.90607744
37Hyperglycinemia (HP:0002154)2.86783593
38Stenosis of the external auditory canal (HP:0000402)2.83955978
39Abolished electroretinogram (ERG) (HP:0000550)2.83561310
40Hypoglycemic seizures (HP:0002173)2.81807892
41Abnormality of fatty-acid metabolism (HP:0004359)2.79667570
42Conjugated hyperbilirubinemia (HP:0002908)2.79209129
43Genetic anticipation (HP:0003743)2.78966115
44True hermaphroditism (HP:0010459)2.78873972
45Nephronophthisis (HP:0000090)2.77278625
46Metabolic acidosis (HP:0001942)2.75196482
47Epidermoid cyst (HP:0200040)2.74955134
48Complement deficiency (HP:0004431)2.73838463
49Hematochezia (HP:0002573)2.73795289
50Hypoplasia of the fovea (HP:0007750)2.71750979
51Aplasia/Hypoplasia of the fovea (HP:0008060)2.71750979
52Eosinophilia (HP:0001880)2.70589655
53Abnormality of the renal medulla (HP:0100957)2.70275392
54Hypoalphalipoproteinemia (HP:0003233)2.68363568
55Skin nodule (HP:0200036)2.67767188
56Short hallux (HP:0010109)2.64820185
57Pancreatic islet-cell hyperplasia (HP:0004510)2.59393044
58Abnormality of glutamine family amino acid metabolism (HP:0010902)2.57710892
59Congenital, generalized hypertrichosis (HP:0004540)2.55865275
60Symptomatic seizures (HP:0011145)2.55841897
61Bile duct proliferation (HP:0001408)2.53825570
62Abnormal biliary tract physiology (HP:0012439)2.53825570
63Aplasia/Hypoplasia of the hallux (HP:0008362)2.52193179
64Decreased central vision (HP:0007663)2.51479958
65Hypobetalipoproteinemia (HP:0003563)2.49576309
66Multiple enchondromatosis (HP:0005701)2.48167983
67Generalized aminoaciduria (HP:0002909)2.44781068
68Abnormality of midbrain morphology (HP:0002418)2.44102733
69Molar tooth sign on MRI (HP:0002419)2.44102733
70Proximal tubulopathy (HP:0000114)2.43978715
71Ragged-red muscle fibers (HP:0003200)2.43882127
72Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.43415943
73Hypolipoproteinemia (HP:0010981)2.41032639
74Abnormality of aspartate family amino acid metabolism (HP:0010899)2.40818371
75Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.40502306
76Abnormal delayed hypersensitivity skin test (HP:0002963)2.40325897
77Abnormality of purine metabolism (HP:0004352)2.39402146
78Enlarged kidneys (HP:0000105)2.38921843
79Stomach cancer (HP:0012126)2.38186599
80Abnormality of eosinophils (HP:0001879)2.38026960
81Abnormality of DNA repair (HP:0003254)2.37154954
82Fair hair (HP:0002286)2.36570122
83Abnormality of the proximal phalanges of the hand (HP:0009834)2.35271754
84Chronic hepatic failure (HP:0100626)2.35037000
85Fat malabsorption (HP:0002630)2.35035277
86Abnormal rod and cone electroretinograms (HP:0008323)2.34426782
873-Methylglutaconic aciduria (HP:0003535)2.34286058
88Ectopic kidney (HP:0000086)2.34211108
89Abnormality of alanine metabolism (HP:0010916)2.33787200
90Hyperalaninemia (HP:0003348)2.33787200
91Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.33787200
92IgG deficiency (HP:0004315)2.33618182
93Myocardial infarction (HP:0001658)2.33537030
94Hypochromic anemia (HP:0001931)2.33426950
95Carpal bone hypoplasia (HP:0001498)2.33030060
96Anomalous pulmonary venous return (HP:0010772)2.32820125
97Absent rod-and cone-mediated responses on ERG (HP:0007688)2.32103035
98Leukocytosis (HP:0001974)2.31759815
99Thyroiditis (HP:0100646)2.31052830
100Attenuation of retinal blood vessels (HP:0007843)2.30492480
101Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.30405645
102Abnormality of methionine metabolism (HP:0010901)2.29816779
103Abnormality of the fovea (HP:0000493)2.28460465
104Abnormality of B cell number (HP:0010975)2.28098436
105Absent/shortened dynein arms (HP:0200106)2.27418191
106Dynein arm defect of respiratory motile cilia (HP:0012255)2.27418191
107Gingival bleeding (HP:0000225)2.27381470
108Clumsiness (HP:0002312)2.24186810
109Oligomenorrhea (HP:0000876)2.22855243
110Abnormality of the common coagulation pathway (HP:0010990)2.21947284
111Pigmentary retinal degeneration (HP:0001146)2.20334223
112Decreased electroretinogram (ERG) amplitude (HP:0000654)2.19546960
113Short phalanx of the thumb (HP:0009660)2.19115396
114Toxemia of pregnancy (HP:0100603)2.18995405
115Type II lissencephaly (HP:0007260)2.16184849
116Hypercholesterolemia (HP:0003124)2.16095473
117Progressive cerebellar ataxia (HP:0002073)2.15712652
118Gaze-evoked nystagmus (HP:0000640)2.15316336
119Abnormal cartilage morphology (HP:0002763)2.14964651
120Abnormality of sulfur amino acid metabolism (HP:0004339)2.13010151
121Absent phalangeal crease (HP:0006109)2.12140280
122Decreased circulating renin level (HP:0003351)2.11816284
123Decreased subcutaneous fat (HP:0001002)2.11497879
124Duplicated collecting system (HP:0000081)2.10227656
125Limb hypertonia (HP:0002509)2.09586640
126Agammaglobulinemia (HP:0004432)2.09506811
127Abnormality of nucleobase metabolism (HP:0010932)2.09458860
128Pustule (HP:0200039)2.09427549
129Malnutrition (HP:0004395)2.08903114
130Hyperbilirubinemia (HP:0002904)2.08430349
131Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.06565783
132Absent thumb (HP:0009777)2.06176084
133Vomiting (HP:0002013)2.05731871
134Gout (HP:0001997)2.05543739
135Myoglobinuria (HP:0002913)2.04265421
136Generalized hypopigmentation of hair (HP:0011358)2.03168359
137Tubular atrophy (HP:0000092)2.03010265
138Abnormality of the phalanges of the 5th finger (HP:0004213)2.02343326
139Cystic liver disease (HP:0006706)2.01782452
140Abnormal finger flexion creases (HP:0006143)2.01432169
141Hyperglycemia (HP:0003074)2.00697866
142Combined immunodeficiency (HP:0005387)1.99420732
143Symphalangism affecting the phalanges of the hand (HP:0009773)1.99173532
144Testicular atrophy (HP:0000029)1.98830179
145Chorioretinal atrophy (HP:0000533)1.98646727
146Granulocytopenia (HP:0001913)1.98210177
147Osteomalacia (HP:0002749)1.97682665
148Pendular nystagmus (HP:0012043)1.97580142
149Pancreatitis (HP:0001733)1.97232604
150Microvesicular hepatic steatosis (HP:0001414)1.96973982
151Fused cervical vertebrae (HP:0002949)1.96174980
152Chromosomal breakage induced by crosslinking agents (HP:0003221)1.94920515
153Partial duplication of thumb phalanx (HP:0009944)1.94847766
154Synostosis of carpal bones (HP:0005048)1.94696125
155Abnormality of the columella (HP:0009929)1.93151292
156Difficulty running (HP:0009046)1.92713385
157Hyperventilation (HP:0002883)1.92481710
158Lethargy (HP:0001254)1.91900994
159Abnormality of the pancreatic islet cells (HP:0006476)1.91791870
160Abnormality of endocrine pancreas physiology (HP:0012093)1.91791870
161Aplasia/Hypoplasia of the macula (HP:0008059)1.91596592
162Chronic mucocutaneous candidiasis (HP:0002728)1.91360083
163Recurrent cutaneous fungal infections (HP:0011370)1.91360083
164Abnormality of the prostate (HP:0008775)1.91350210
165Cheilitis (HP:0100825)1.89729906
166Abnormality of the pulmonary veins (HP:0011718)1.89244536
167Abnormality of proline metabolism (HP:0010907)1.88481367
168Hydroxyprolinuria (HP:0003080)1.88481367
169Morphological abnormality of the middle ear (HP:0008609)1.88366366
170Abnormality of complement system (HP:0005339)1.87965264
171Panhypogammaglobulinemia (HP:0003139)1.86305112
172Prostate neoplasm (HP:0100787)1.86275223
173Bony spicule pigmentary retinopathy (HP:0007737)1.85824595
174Amyloidosis (HP:0011034)1.85563830
175Congenital hepatic fibrosis (HP:0002612)1.84764759
176Stomatitis (HP:0010280)1.84633372
177Insulin-resistant diabetes mellitus (HP:0000831)1.82866214
178Recurrent fungal infections (HP:0002841)1.82697807
179Abnormal enzyme/coenzyme activity (HP:0012379)1.81742127
180Visual hallucinations (HP:0002367)1.80177198
181Elevated alkaline phosphatase (HP:0003155)1.79023659
182Prolonged bleeding time (HP:0003010)1.76882312
183Albinism (HP:0001022)1.76003651
184Tented upper lip vermilion (HP:0010804)1.75991496
185Increased purine levels (HP:0004368)1.74671418
186Hyperuricemia (HP:0002149)1.74671418
187Abnormal drinking behavior (HP:0030082)1.74666421
188Polydipsia (HP:0001959)1.74666421
189Elevated hepatic transaminases (HP:0002910)1.73115728
190Rib fusion (HP:0000902)1.72495309
191Orchitis (HP:0100796)1.72021002
192Tachypnea (HP:0002789)1.71635902
193Hyperkalemia (HP:0002153)1.71520513
194Medial flaring of the eyebrow (HP:0010747)1.70227617

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.42451810
2ERN13.89167089
3GRK13.38845392
4GRK62.98332862
5INSRR2.97798623
6PINK12.84265148
7ADRBK22.80664732
8GRK52.80489798
9TGFBR22.74291134
10CSF1R2.73401807
11ACVR1B2.64191752
12BCKDK2.28979127
13MAPK72.18520229
14TAOK32.18225397
15SIK12.11500298
16BMPR1B2.03946012
17GRK71.99877699
18FGFR31.73778387
19IRAK31.73294702
20WNK11.63762510
21TLK11.48523690
22STK101.47678115
23PLK21.46446725
24FGFR41.41716445
25MATK1.40333943
26WNK41.38036350
27MAPK131.36023075
28KIT1.35984436
29MAP3K141.34429541
30MARK31.30082983
31CSK1.26467834
32ITK1.26309527
33TXK1.25541682
34MAP4K21.22636984
35HIPK21.21101272
36FES1.20608363
37PRKAA21.20450749
38CAMK1D1.12138285
39CAMKK21.10202850
40EPHB11.09548971
41MAP4K11.08523972
42FLT31.08068546
43MARK21.06497813
44MAPK121.06182829
45IRAK41.06182705
46MOS1.03794196
47MAP2K11.03139192
48TEC1.02925222
49DAPK21.00290879
50SGK20.99243281
51MAP3K70.97627185
52TYK20.97483391
53MAPK150.97166523
54JAK30.95792928
55RIPK40.94490985
56CAMK40.94326573
57TTK0.93575276
58JAK10.93567822
59PTK2B0.93392732
60MAPKAPK30.90611299
61IRAK10.88642025
62MAP2K60.87601003
63PIK3CG0.87373410
64IKBKB0.83803383
65PRKG20.83210840
66CDK90.83126804
67OBSCN0.83032622
68TGFBR10.82691237
69ZAK0.82342615
70EIF2AK20.79870963
71TIE10.79462733
72MAP2K40.79055198
73MAP3K130.78872651
74PHKG10.78108440
75PHKG20.78108440
76PKN10.77670466
77MAP3K60.77423163
78FRK0.76903245
79MAPK110.76460713
80EPHA30.75429772
81STK380.74541924
82NEK20.72623081
83NUAK10.70159574
84IGF1R0.69212403
85LATS10.68154224
86PRKCQ0.67039126
87BTK0.65935260
88STK38L0.65742380
89NLK0.64800526
90MAP3K40.64269554
91SGK4940.64036615
92SGK2230.64036615
93PRKAA10.62461357
94ADRBK10.61990698
95ERBB40.61988360
96ZAP700.60890005
97JAK20.60677235
98BMPR20.60348729
99IKBKE0.59124172
100WNK30.58735629
101CAMK1G0.58577410
102STK390.58470793
103PAK30.58392622
104SGK30.58031316
105PRKCE0.58025862
106CDK70.57945232
107MAPK40.57796007
108PRKD20.56951910
109IRAK20.55316046
110CHUK0.54317694
111FGFR20.53230495
112RPS6KA60.52541718
113RPS6KA50.50219389
114MAP2K70.50092357
115OXSR10.49286326
116STK240.48925758
117SGK10.48395992
118TYRO30.48052607
119SYK0.47673051
120TNIK0.46830083
121LCK0.46556296
122CAMK10.45475369
123BLK0.44710181
124STK30.44440934
125NEK90.42721514
126TNK20.42284282
127TRPM70.41428367
128PRKACA0.40319160
129PRKG10.40049949
130PRKCH0.39924457
131MUSK0.39753139
132LYN0.39112109
133HCK0.38992959
134AKT30.38194388
135PRKACG0.38025674
136PIK3CA0.36564838
137PRKCD0.34196910
138CDK30.33995757
139CHEK20.33768975
140EGFR0.33678431
141GSK3A0.33393823
142ABL10.32578423

Predicted pathways (KEGG)

RankGene SetZ-score
1Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.21680805
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.18269350
3Vitamin B6 metabolism_Homo sapiens_hsa007502.99149400
4Asthma_Homo sapiens_hsa053102.90234339
5Tryptophan metabolism_Homo sapiens_hsa003802.78910680
6Phototransduction_Homo sapiens_hsa047442.68065115
7Fatty acid degradation_Homo sapiens_hsa000712.57845687
8Propanoate metabolism_Homo sapiens_hsa006402.50343960
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.48139865
10Pentose and glucuronate interconversions_Homo sapiens_hsa000402.45380864
11Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.36165297
12Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.35944345
13Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.35534307
14Allograft rejection_Homo sapiens_hsa053302.32670048
15Graft-versus-host disease_Homo sapiens_hsa053322.25057168
16Complement and coagulation cascades_Homo sapiens_hsa046102.23152844
17Autoimmune thyroid disease_Homo sapiens_hsa053202.21057150
18Peroxisome_Homo sapiens_hsa041462.15583028
19PPAR signaling pathway_Homo sapiens_hsa033202.11217641
20Fatty acid elongation_Homo sapiens_hsa000622.11083577
21Histidine metabolism_Homo sapiens_hsa003402.06063322
22Fatty acid metabolism_Homo sapiens_hsa012122.01553775
23Retinol metabolism_Homo sapiens_hsa008301.98520425
24Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.96332738
25Chemical carcinogenesis_Homo sapiens_hsa052041.95781237
26Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.93354130
27beta-Alanine metabolism_Homo sapiens_hsa004101.87859906
28Butanoate metabolism_Homo sapiens_hsa006501.85803859
29Type I diabetes mellitus_Homo sapiens_hsa049401.85000333
30Steroid hormone biosynthesis_Homo sapiens_hsa001401.75441568
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.72503524
32Maturity onset diabetes of the young_Homo sapiens_hsa049501.64285283
33alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.62185402
34Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.60317205
35Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.57393869
36Sulfur metabolism_Homo sapiens_hsa009201.56946042
37ABC transporters_Homo sapiens_hsa020101.54055846
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.53929613
39Linoleic acid metabolism_Homo sapiens_hsa005911.53694223
40Arginine biosynthesis_Homo sapiens_hsa002201.48978399
41Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.42873429
42Caffeine metabolism_Homo sapiens_hsa002321.42188973
43Nitrogen metabolism_Homo sapiens_hsa009101.40145797
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.39852029
45Staphylococcus aureus infection_Homo sapiens_hsa051501.39580595
46Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.36018441
47Arachidonic acid metabolism_Homo sapiens_hsa005901.34965724
48Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.33188487
49Folate biosynthesis_Homo sapiens_hsa007901.32931888
50Tyrosine metabolism_Homo sapiens_hsa003501.32641507
51Dorso-ventral axis formation_Homo sapiens_hsa043201.23889634
52Phenylalanine metabolism_Homo sapiens_hsa003601.23376638
53Olfactory transduction_Homo sapiens_hsa047401.20796177
54Pyruvate metabolism_Homo sapiens_hsa006201.18762404
55* Starch and sucrose metabolism_Homo sapiens_hsa005001.13123447
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.10043738
57Drug metabolism - other enzymes_Homo sapiens_hsa009831.07724960
58Fructose and mannose metabolism_Homo sapiens_hsa000511.06772092
59Leishmaniasis_Homo sapiens_hsa051401.05955855
60Lysine degradation_Homo sapiens_hsa003101.03344027
61B cell receptor signaling pathway_Homo sapiens_hsa046621.02406269
62Glycerolipid metabolism_Homo sapiens_hsa005611.01995450
63Selenocompound metabolism_Homo sapiens_hsa004501.00590095
64Systemic lupus erythematosus_Homo sapiens_hsa053220.96590471
65Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.93497360
66Primary immunodeficiency_Homo sapiens_hsa053400.91751377
67Rheumatoid arthritis_Homo sapiens_hsa053230.90737749
68Fat digestion and absorption_Homo sapiens_hsa049750.90629726
69Platelet activation_Homo sapiens_hsa046110.90019530
70Vascular smooth muscle contraction_Homo sapiens_hsa042700.89698058
71Osteoclast differentiation_Homo sapiens_hsa043800.87314011
72Calcium signaling pathway_Homo sapiens_hsa040200.86600685
73Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.86107617
74Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.86078689
75Steroid biosynthesis_Homo sapiens_hsa001000.85909205
76Morphine addiction_Homo sapiens_hsa050320.85868512
77Vitamin digestion and absorption_Homo sapiens_hsa049770.85132612
78Arginine and proline metabolism_Homo sapiens_hsa003300.81124827
792-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.80848469
80Ether lipid metabolism_Homo sapiens_hsa005650.80390143
81Carbon metabolism_Homo sapiens_hsa012000.80317846
82Serotonergic synapse_Homo sapiens_hsa047260.79081806
83Salivary secretion_Homo sapiens_hsa049700.78971812
84Other glycan degradation_Homo sapiens_hsa005110.76074434
85Antigen processing and presentation_Homo sapiens_hsa046120.76063292
86Tuberculosis_Homo sapiens_hsa051520.74315340
87Bile secretion_Homo sapiens_hsa049760.72347530
88Taste transduction_Homo sapiens_hsa047420.71639022
89Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.71447311
90NOD-like receptor signaling pathway_Homo sapiens_hsa046210.71378568
91Sulfur relay system_Homo sapiens_hsa041220.69528747
92Fatty acid biosynthesis_Homo sapiens_hsa000610.69412935
93Oxytocin signaling pathway_Homo sapiens_hsa049210.68632003
94SNARE interactions in vesicular transport_Homo sapiens_hsa041300.68476067
95Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.67286626
96T cell receptor signaling pathway_Homo sapiens_hsa046600.64746713
97Renin secretion_Homo sapiens_hsa049240.63516432
98Fanconi anemia pathway_Homo sapiens_hsa034600.62343711
99Viral myocarditis_Homo sapiens_hsa054160.61311707
100Ovarian steroidogenesis_Homo sapiens_hsa049130.61043049
101Circadian rhythm_Homo sapiens_hsa047100.61022811
102* Metabolic pathways_Homo sapiens_hsa011000.59134472
103Circadian entrainment_Homo sapiens_hsa047130.58357775
104Glycerophospholipid metabolism_Homo sapiens_hsa005640.57147191
105Intestinal immune network for IgA production_Homo sapiens_hsa046720.55051782
106RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.53690016
107Insulin resistance_Homo sapiens_hsa049310.52574908
108RNA degradation_Homo sapiens_hsa030180.52359456
109NF-kappa B signaling pathway_Homo sapiens_hsa040640.52180982
110Homologous recombination_Homo sapiens_hsa034400.51004843
111* Galactose metabolism_Homo sapiens_hsa000520.50523111
112Renin-angiotensin system_Homo sapiens_hsa046140.50119185
113Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.48810399
114Adipocytokine signaling pathway_Homo sapiens_hsa049200.48221087
115Pentose phosphate pathway_Homo sapiens_hsa000300.47975963
116Nicotine addiction_Homo sapiens_hsa050330.47236581
117Carbohydrate digestion and absorption_Homo sapiens_hsa049730.45943453
118Type II diabetes mellitus_Homo sapiens_hsa049300.45894372
119Glutathione metabolism_Homo sapiens_hsa004800.45709250
120Phagosome_Homo sapiens_hsa041450.45370028
121Glutamatergic synapse_Homo sapiens_hsa047240.44895401
122Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.44779595
123Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.44623078
124Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.43681785
125Basal transcription factors_Homo sapiens_hsa030220.42526920
126Cysteine and methionine metabolism_Homo sapiens_hsa002700.41447608
127Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.40700735
128Long-term depression_Homo sapiens_hsa047300.40487504
129Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.39788572
130Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.38174420
131Toxoplasmosis_Homo sapiens_hsa051450.37671900
132Hematopoietic cell lineage_Homo sapiens_hsa046400.37499519
133Glycosaminoglycan degradation_Homo sapiens_hsa005310.34690851
134Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.34629678
135Herpes simplex infection_Homo sapiens_hsa051680.34199994
136Protein export_Homo sapiens_hsa030600.34199328
137AMPK signaling pathway_Homo sapiens_hsa041520.33032726
138Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.31702001
139Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.31464265
140Regulation of autophagy_Homo sapiens_hsa041400.30042207
141One carbon pool by folate_Homo sapiens_hsa006700.27049322
142Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.26766529
143Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.26223198
144Biosynthesis of amino acids_Homo sapiens_hsa012300.25763190
145Cyanoamino acid metabolism_Homo sapiens_hsa004600.22119471
146Non-homologous end-joining_Homo sapiens_hsa034500.19716771
147Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.19651549
148Jak-STAT signaling pathway_Homo sapiens_hsa046300.15155276
149Transcriptional misregulation in cancer_Homo sapiens_hsa052020.14638332
150Sphingolipid metabolism_Homo sapiens_hsa006000.12556804

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