GAP43

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This protein is considered a crucial component of an effective regenerative response in the nervous system. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)6.14956982
2vocalization behavior (GO:0071625)5.50378231
3pyrimidine nucleobase catabolic process (GO:0006208)5.34558336
4negative regulation of microtubule polymerization (GO:0031115)5.23800013
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.08106831
6layer formation in cerebral cortex (GO:0021819)4.81964159
7regulation of short-term neuronal synaptic plasticity (GO:0048172)4.81466836
8protein localization to synapse (GO:0035418)4.80198054
9synaptic vesicle exocytosis (GO:0016079)4.76233030
10dendritic spine morphogenesis (GO:0060997)4.72228897
11positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.62378240
12nucleobase catabolic process (GO:0046113)4.56169105
13regulation of glutamate receptor signaling pathway (GO:1900449)4.46429572
14* neuron recognition (GO:0008038)4.35772273
15behavioral response to nicotine (GO:0035095)4.29372451
16membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.23918826
17positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.22864856
18axonal fasciculation (GO:0007413)4.20354918
19exploration behavior (GO:0035640)4.09644480
20cell migration in hindbrain (GO:0021535)4.07218576
21regulation of synaptic vesicle exocytosis (GO:2000300)4.04410617
22postsynaptic membrane organization (GO:0001941)4.02009440
23ionotropic glutamate receptor signaling pathway (GO:0035235)4.01840736
24proline transport (GO:0015824)3.89892033
25glutamate receptor signaling pathway (GO:0007215)3.89392177
26glutamate secretion (GO:0014047)3.86971435
27regulation of synapse structural plasticity (GO:0051823)3.84842556
28locomotory exploration behavior (GO:0035641)3.83552204
29synaptic vesicle maturation (GO:0016188)3.82789843
30neurotransmitter secretion (GO:0007269)3.81757142
31positive regulation of synapse assembly (GO:0051965)3.79392262
32mechanosensory behavior (GO:0007638)3.70330050
33presynaptic membrane assembly (GO:0097105)3.64693506
34regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.64456945
35regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.62583397
36regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.61585375
37mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.61169947
38neurofilament cytoskeleton organization (GO:0060052)3.60925651
39energy coupled proton transport, down electrochemical gradient (GO:0015985)3.55280161
40ATP synthesis coupled proton transport (GO:0015986)3.55280161
41neuronal ion channel clustering (GO:0045161)3.52221751
42dendrite morphogenesis (GO:0048813)3.51716169
43neuron-neuron synaptic transmission (GO:0007270)3.49831672
44mating behavior (GO:0007617)3.48823562
45regulation of synaptic vesicle transport (GO:1902803)3.48199108
46transmission of nerve impulse (GO:0019226)3.47422952
47synapse assembly (GO:0007416)3.46958921
48positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.46049792
49dopamine biosynthetic process (GO:0042416)3.44343167
50regulation of long-term neuronal synaptic plasticity (GO:0048169)3.42587213
51synaptic transmission, glutamatergic (GO:0035249)3.40822487
52membrane depolarization during action potential (GO:0086010)3.40060838
53response to histamine (GO:0034776)3.37088559
54gamma-aminobutyric acid transport (GO:0015812)3.36571833
55sequestering of actin monomers (GO:0042989)3.35306363
56negative regulation of synaptic transmission, GABAergic (GO:0032229)3.35106675
57presynaptic membrane organization (GO:0097090)3.33995468
58neurotransmitter transport (GO:0006836)3.33113882
59neuromuscular synaptic transmission (GO:0007274)3.32929012
60prepulse inhibition (GO:0060134)3.31883770
61positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.27055207
62regulation of vesicle fusion (GO:0031338)3.24914986
63catecholamine transport (GO:0051937)3.23995184
64axon extension (GO:0048675)3.23826618
65regulation of postsynaptic membrane potential (GO:0060078)3.22757265
66neurotransmitter-gated ion channel clustering (GO:0072578)3.22688365
67auditory behavior (GO:0031223)3.22214201
68adult walking behavior (GO:0007628)3.22084117
69regulation of neuronal synaptic plasticity (GO:0048168)3.21501646
70regulation of glutamate secretion (GO:0014048)3.20543491
71dopamine transport (GO:0015872)3.20378605
72central nervous system projection neuron axonogenesis (GO:0021952)3.20038271
73regulation of excitatory postsynaptic membrane potential (GO:0060079)3.19490698
74positive regulation of dendritic spine morphogenesis (GO:0061003)3.19457310
75dendrite development (GO:0016358)3.17705462
76gamma-aminobutyric acid signaling pathway (GO:0007214)3.16752516
77positive regulation of synaptic transmission, GABAergic (GO:0032230)3.15763210
78regulation of neurotransmitter levels (GO:0001505)3.15398871
79regulation of dopamine secretion (GO:0014059)3.13867628
80regulation of respiratory system process (GO:0044065)3.13022158
81membrane depolarization (GO:0051899)3.12771032
82regulation of synapse assembly (GO:0051963)3.08495594
83dopamine receptor signaling pathway (GO:0007212)3.07733008
84opioid receptor signaling pathway (GO:0038003)3.07492109
85synaptic vesicle endocytosis (GO:0048488)3.06138516
86establishment of mitochondrion localization (GO:0051654)3.05920957
87mitochondrion transport along microtubule (GO:0047497)3.04401885
88establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.04401885
89positive regulation of synapse maturation (GO:0090129)3.03587887
90regulation of cAMP-dependent protein kinase activity (GO:2000479)3.02395493
91neuron projection extension (GO:1990138)3.02239640
92regulation of dendritic spine morphogenesis (GO:0061001)3.02043822
93intraspecies interaction between organisms (GO:0051703)3.01972667
94social behavior (GO:0035176)3.01972667
95mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.01940129
96retinal ganglion cell axon guidance (GO:0031290)3.01441322
97positive regulation of membrane potential (GO:0045838)3.00502491
98synapse organization (GO:0050808)3.00134805
99innervation (GO:0060384)2.99833707
100G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.99011817
101neuronal action potential propagation (GO:0019227)2.99001105
102regulation of microtubule polymerization (GO:0031113)2.98957090
103adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.98680132
104behavioral response to cocaine (GO:0048148)2.98344414
105positive regulation of microtubule polymerization or depolymerization (GO:0031112)2.98337768
106regulation of synaptic transmission, glutamatergic (GO:0051966)2.96726208
107synaptic vesicle docking involved in exocytosis (GO:0016081)2.96306404
108negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.94547120
109G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.93597538
110negative regulation of axon extension (GO:0030517)2.93103679
111regulation of protein kinase A signaling (GO:0010738)2.92817516
112organelle transport along microtubule (GO:0072384)2.92190558
113dendritic spine organization (GO:0097061)2.92072154
114regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.91773780
115long-term memory (GO:0007616)2.91210421
116startle response (GO:0001964)2.89806509
117response to auditory stimulus (GO:0010996)2.89700134
118activation of protein kinase A activity (GO:0034199)2.89665209
119regulation of respiratory gaseous exchange (GO:0043576)2.89368653
120hippocampus development (GO:0021766)2.89196221
121negative regulation of axonogenesis (GO:0050771)2.88041171
122positive regulation of dendritic spine development (GO:0060999)2.87670983
123neuronal action potential (GO:0019228)2.84874368
124cellular potassium ion homeostasis (GO:0030007)2.79907539
125regulation of synapse organization (GO:0050807)2.78508024
126cerebral cortex radially oriented cell migration (GO:0021799)2.77948662
127synaptic transmission, cholinergic (GO:0007271)2.77709078
128central nervous system neuron axonogenesis (GO:0021955)2.77039060

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.65665263
2GBX2_23144817_ChIP-Seq_PC3_Human3.66793471
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.15341662
4NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.08406374
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.05775189
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.89872077
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.87392609
8REST_21632747_ChIP-Seq_MESCs_Mouse2.72201430
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.66558054
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.59568000
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.59568000
12TAF15_26573619_Chip-Seq_HEK293_Human2.59373006
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.56112755
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.54591164
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.51623446
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.43935198
17CTBP2_25329375_ChIP-Seq_LNCAP_Human2.36749556
18CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.33625540
19SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.33198680
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.32526750
21MTF2_20144788_ChIP-Seq_MESCs_Mouse2.30742254
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.24854490
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.21501156
24CTBP1_25329375_ChIP-Seq_LNCAP_Human2.16652070
25BMI1_23680149_ChIP-Seq_NPCS_Mouse2.16283421
26REST_18959480_ChIP-ChIP_MESCs_Mouse2.15730660
27AR_21572438_ChIP-Seq_LNCaP_Human2.11642054
28RNF2_27304074_Chip-Seq_ESCs_Mouse2.08229550
29ZNF274_21170338_ChIP-Seq_K562_Hela2.03718198
30CBX2_27304074_Chip-Seq_ESCs_Mouse1.97108911
31* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.92873215
32IKZF1_21737484_ChIP-ChIP_HCT116_Human1.91396413
33RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.85357254
34DROSHA_22980978_ChIP-Seq_HELA_Human1.78096130
35RNF2_27304074_Chip-Seq_NSC_Mouse1.71758051
36RARB_27405468_Chip-Seq_BRAIN_Mouse1.70505019
37IGF1R_20145208_ChIP-Seq_DFB_Human1.69855007
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.68685142
39* P300_19829295_ChIP-Seq_ESCs_Human1.67131005
40ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.61526186
41* SMAD4_21799915_ChIP-Seq_A2780_Human1.58903493
42TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.55242083
43* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.55137401
44* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.54574699
45HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.48037734
46POU3F2_20337985_ChIP-ChIP_501MEL_Human1.45292750
47SMAD3_21741376_ChIP-Seq_EPCs_Human1.41770758
48SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40258488
49FUS_26573619_Chip-Seq_HEK293_Human1.40103020
50ERG_21242973_ChIP-ChIP_JURKAT_Human1.39478986
51* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.37684927
52RING1B_27294783_Chip-Seq_ESCs_Mouse1.34892049
53SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.33492967
54* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.32779847
55MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.31254629
56VDR_22108803_ChIP-Seq_LS180_Human1.31142888
57* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30790984
58CDX2_19796622_ChIP-Seq_MESCs_Mouse1.28019124
59GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27853430
60* SOX2_21211035_ChIP-Seq_LN229_Gbm1.27664160
61* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27523707
62AR_25329375_ChIP-Seq_VCAP_Human1.26818932
63TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.26184303
64PIAS1_25552417_ChIP-Seq_VCAP_Human1.25101839
65* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.23836482
66GATA1_26923725_Chip-Seq_HPCs_Mouse1.17618117
67ER_23166858_ChIP-Seq_MCF-7_Human1.17439018
68* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16124413
69RUNX2_22187159_ChIP-Seq_PCA_Human1.15716514
70RING1B_27294783_Chip-Seq_NPCs_Mouse1.15495794
71* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15082228
72JUN_21703547_ChIP-Seq_K562_Human1.14605859
73* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.12402658
74TP53_20018659_ChIP-ChIP_R1E_Mouse1.12279821
75KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.11486710
76P53_22127205_ChIP-Seq_FIBROBLAST_Human1.11152358
77EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.09253021
78RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.04600378
79MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04043819
80STAT3_23295773_ChIP-Seq_U87_Human1.02956976
81TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01935935
82ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.00946977
83AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.00872302
84* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00866373
85* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00866373
86* PRDM14_20953172_ChIP-Seq_ESCs_Human1.00229101
87NR3C1_21868756_ChIP-Seq_MCF10A_Human0.99488550
88FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.99332063
89ARNT_22903824_ChIP-Seq_MCF-7_Human0.98529848
90LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98447161
91* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.97607363
92AR_19668381_ChIP-Seq_PC3_Human0.97414545
93CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.96997424
94AHR_22903824_ChIP-Seq_MCF-7_Human0.96665355
95TCF4_23295773_ChIP-Seq_U87_Human0.96556510
96* CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.94402649
97TP53_18474530_ChIP-ChIP_U2OS_Human0.94306956
98EWS_26573619_Chip-Seq_HEK293_Human0.93674035
99TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93320996
100BCAT_22108803_ChIP-Seq_LS180_Human0.92770243
101EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.91688154
102* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.91144319
103BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.91090665
104MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.90783764
105KDM2B_26808549_Chip-Seq_REH_Human0.89036829
106CTCF_27219007_Chip-Seq_Bcells_Human0.88821352
107NANOG_18555785_Chip-Seq_ESCs_Mouse0.88396732
108* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.87892193
109* DNAJC2_21179169_ChIP-ChIP_NT2_Human0.87877458
110WT1_25993318_ChIP-Seq_PODOCYTE_Human0.87592686
111SOX9_26525672_Chip-Seq_HEART_Mouse0.87518731
112* SMAD3_21741376_ChIP-Seq_ESCs_Human0.86433883
113GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.86301572
114TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.85571752
115RBPJ_22232070_ChIP-Seq_NCS_Mouse0.84814149

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.99526833
2MP0004859_abnormal_synaptic_plasticity4.36495248
3MP0003635_abnormal_synaptic_transmissio3.63140781
4MP0006276_abnormal_autonomic_nervous3.49413243
5MP0005423_abnormal_somatic_nervous3.45125845
6MP0004270_analgesia3.44505497
7MP0002063_abnormal_learning/memory/cond3.06497672
8MP0009745_abnormal_behavioral_response3.00685559
9MP0001968_abnormal_touch/_nociception2.97147961
10MP0002734_abnormal_mechanical_nocicepti2.78148909
11MP0001529_abnormal_vocalization2.73468873
12MP0002572_abnormal_emotion/affect_behav2.72692168
13MP0002064_seizures2.62543926
14MP0009046_muscle_twitch2.51794364
15MP0001440_abnormal_grooming_behavior2.47137065
16MP0002735_abnormal_chemical_nociception2.47012140
17MP0002184_abnormal_innervation2.40497451
18* MP0000778_abnormal_nervous_system2.34979279
19MP0002733_abnormal_thermal_nociception2.32936634
20MP0002736_abnormal_nociception_after2.32800940
21MP0003122_maternal_imprinting2.31705666
22MP0001486_abnormal_startle_reflex2.28909151
23MP0002272_abnormal_nervous_system2.19952718
24MP0001905_abnormal_dopamine_level2.12741093
25MP0001970_abnormal_pain_threshold2.06533673
26MP0002822_catalepsy2.06529638
27MP0005386_behavior/neurological_phenoty1.99704775
28MP0004924_abnormal_behavior1.99704775
29MP0002557_abnormal_social/conspecific_i1.97384504
30MP0002067_abnormal_sensory_capabilities1.97162434
31MP0001501_abnormal_sleep_pattern1.94761961
32MP0005645_abnormal_hypothalamus_physiol1.89900501
33MP0001188_hyperpigmentation1.83454176
34MP0001984_abnormal_olfaction1.83438751
35MP0009379_abnormal_foot_pigmentation1.75608545
36MP0004811_abnormal_neuron_physiology1.67725450
37MP0004858_abnormal_nervous_system1.60962350
38MP0000955_abnormal_spinal_cord1.56620371
39MP0004142_abnormal_muscle_tone1.46680561
40* MP0002882_abnormal_neuron_morphology1.45951428
41MP0002909_abnormal_adrenal_gland1.44485009
42MP0003329_amyloid_beta_deposits1.43999832
43MP0002066_abnormal_motor_capabilities/c1.38577049
44MP0000751_myopathy1.38458316
45MP0003123_paternal_imprinting1.35532029
46MP0000566_synostosis1.32149039
47MP0008877_abnormal_DNA_methylation1.31568667
48MP0002102_abnormal_ear_morphology1.27880854
49MP0004133_heterotaxia1.27089111
50MP0004742_abnormal_vestibular_system1.26674447
51MP0002638_abnormal_pupillary_reflex1.25497865
52MP0005394_taste/olfaction_phenotype1.24445807
53MP0005499_abnormal_olfactory_system1.24445807
54MP0002837_dystrophic_cardiac_calcinosis1.22364969
55MP0005646_abnormal_pituitary_gland1.22234884
56* MP0002152_abnormal_brain_morphology1.22161352
57MP0001502_abnormal_circadian_rhythm1.18993218
58MP0005409_darkened_coat_color1.14716454
59MP0010386_abnormal_urinary_bladder1.14420743
60MP0003787_abnormal_imprinting1.13735160
61MP0008569_lethality_at_weaning1.13398528
62MP0000631_abnormal_neuroendocrine_gland1.12701313
63MP0002751_abnormal_autonomic_nervous1.07001018
64MP0003879_abnormal_hair_cell1.04720081
65MP0000569_abnormal_digit_pigmentation1.01953692
66* MP0002752_abnormal_somatic_nervous0.99363362
67MP0008872_abnormal_physiological_respon0.99098758
68MP0002653_abnormal_ependyma_morphology0.97929058
69MP0008789_abnormal_olfactory_epithelium0.97766009
70MP0009780_abnormal_chondrocyte_physiolo0.96501524
71MP0003121_genomic_imprinting0.95106093
72MP0002069_abnormal_eating/drinking_beha0.93948117
73MP0003890_abnormal_embryonic-extraembry0.93100946
74MP0006072_abnormal_retinal_apoptosis0.93060580
75MP0003283_abnormal_digestive_organ0.92923315
76MP0000538_abnormal_urinary_bladder0.87365446
77MP0005551_abnormal_eye_electrophysiolog0.87164770
78MP0003938_abnormal_ear_development0.85967303
79MP0005535_abnormal_body_temperature0.85710930
80MP0002229_neurodegeneration0.85530672
81MP0004885_abnormal_endolymph0.84844438
82MP0001963_abnormal_hearing_physiology0.84273997
83* MP0003861_abnormal_nervous_system0.83496437
84MP0004085_abnormal_heartbeat0.82489953
85MP0001485_abnormal_pinna_reflex0.81102992
86MP0003631_nervous_system_phenotype0.79240007
87MP0005187_abnormal_penis_morphology0.75056088
88MP0003634_abnormal_glial_cell0.74931918
89MP0000026_abnormal_inner_ear0.74474346
90MP0003633_abnormal_nervous_system0.74167891
91MP0004145_abnormal_muscle_electrophysio0.70853746
92MP0001943_abnormal_respiration0.68407217
93MP0001664_abnormal_digestion0.68069411
94MP0005253_abnormal_eye_physiology0.67122730
95MP0006035_abnormal_mitochondrial_morpho0.66437229
96* MP0005195_abnormal_posterior_eye0.65616654
97MP0003632_abnormal_nervous_system0.64942798
98MP0002876_abnormal_thyroid_physiology0.64680349
99MP0003137_abnormal_impulse_conducting0.64619519
100MP0006292_abnormal_olfactory_placode0.64150513
101MP0002090_abnormal_vision0.62028795
102MP0003119_abnormal_digestive_system0.61853808
103MP0000534_abnormal_ureter_morphology0.61231943
104MP0002081_perinatal_lethality0.61095151
105MP0002163_abnormal_gland_morphology0.61031195
106MP0003315_abnormal_perineum_morphology0.60747214
107MP0002928_abnormal_bile_duct0.59306652
108MP0000015_abnormal_ear_pigmentation0.58926892
109MP0008874_decreased_physiological_sensi0.58214749
110MP0003011_delayed_dark_adaptation0.58010189
111* MP0010768_mortality/aging0.57127240
112MP0005379_endocrine/exocrine_gland_phen0.56952346
113MP0001986_abnormal_taste_sensitivity0.55946042
114* MP0002082_postnatal_lethality0.55528586
115* MP0010770_preweaning_lethality0.55528586
116MP0001348_abnormal_lacrimal_gland0.54999387
117MP0001177_atelectasis0.53089325
118MP0001299_abnormal_eye_distance/0.52946227
119MP0000604_amyloidosis0.52563036
120* MP0010769_abnormal_survival0.52297493

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.50902920
2Limb dystonia (HP:0002451)5.47315836
3Focal motor seizures (HP:0011153)5.22532332
4Visual hallucinations (HP:0002367)4.85111053
5Focal seizures (HP:0007359)4.84162978
6Atonic seizures (HP:0010819)4.07239117
7Progressive cerebellar ataxia (HP:0002073)3.89218135
8Polyphagia (HP:0002591)3.78166958
9Mutism (HP:0002300)3.64101024
10Absence seizures (HP:0002121)3.61608337
11Epileptic encephalopathy (HP:0200134)3.56162300
12Febrile seizures (HP:0002373)3.49200911
13Amblyopia (HP:0000646)3.42373763
14Broad-based gait (HP:0002136)3.36149495
15Generalized tonic-clonic seizures (HP:0002069)3.30636832
16Dialeptic seizures (HP:0011146)3.24723630
17Amyotrophic lateral sclerosis (HP:0007354)3.14498423
18Supranuclear gaze palsy (HP:0000605)3.12237684
19Drooling (HP:0002307)3.09663784
20Excessive salivation (HP:0003781)3.09663784
21Cerebral inclusion bodies (HP:0100314)3.07966322
22Acute necrotizing encephalopathy (HP:0006965)3.03954566
23Failure to thrive in infancy (HP:0001531)2.99266091
24Abnormality of the corticospinal tract (HP:0002492)2.95576137
25Ankle clonus (HP:0011448)2.93697080
26Progressive inability to walk (HP:0002505)2.88684076
27Gait imbalance (HP:0002141)2.88263710
28Progressive macrocephaly (HP:0004481)2.85321167
29Agitation (HP:0000713)2.84723231
30Aplasia/Hypoplasia of the brainstem (HP:0007362)2.80610055
31Hypoplasia of the brainstem (HP:0002365)2.80610055
32Abnormal eating behavior (HP:0100738)2.80320450
33Hypothermia (HP:0002045)2.79151355
34Pachygyria (HP:0001302)2.77010277
35Pheochromocytoma (HP:0002666)2.74070883
36Anxiety (HP:0000739)2.72135261
37Hyperventilation (HP:0002883)2.71052699
38Termporal pattern (HP:0011008)2.68470044
39Insidious onset (HP:0003587)2.68470044
40Abnormal mitochondria in muscle tissue (HP:0008316)2.63076022
41Neurofibrillary tangles (HP:0002185)2.61264869
42Truncal ataxia (HP:0002078)2.60022006
43Akinesia (HP:0002304)2.56198055
44Cortical dysplasia (HP:0002539)2.55883498
45Hypoventilation (HP:0002791)2.53828130
46Retinal dysplasia (HP:0007973)2.50212415
47Fetal akinesia sequence (HP:0001989)2.48391483
48Neuroendocrine neoplasm (HP:0100634)2.47923289
49Action tremor (HP:0002345)2.46684893
50Poor suck (HP:0002033)2.46475297
51Urinary urgency (HP:0000012)2.41835989
52EEG with generalized epileptiform discharges (HP:0011198)2.39519014
53Epileptiform EEG discharges (HP:0011182)2.39218054
54Impaired vibration sensation in the lower limbs (HP:0002166)2.38366032
55Spastic tetraplegia (HP:0002510)2.36743594
56Urinary bladder sphincter dysfunction (HP:0002839)2.35783380
57Lissencephaly (HP:0001339)2.35544314
58Morphological abnormality of the pyramidal tract (HP:0002062)2.33498479
59Esotropia (HP:0000565)2.32892416
60Mitochondrial inheritance (HP:0001427)2.29226976
61Exotropia (HP:0000577)2.27812012
62Hypsarrhythmia (HP:0002521)2.27646485
63Abnormal hair whorl (HP:0010721)2.27086442
64Poor eye contact (HP:0000817)2.26560885
65Hemiparesis (HP:0001269)2.26362083
66Hyperthyroidism (HP:0000836)2.24204729
67Diplopia (HP:0000651)2.22160906
68Abnormality of binocular vision (HP:0011514)2.22160906
69Torticollis (HP:0000473)2.21844104
70Status epilepticus (HP:0002133)2.21437042
71Papilledema (HP:0001085)2.21317716
72Inability to walk (HP:0002540)2.21085988
73Spastic gait (HP:0002064)2.17879680
74Specific learning disability (HP:0001328)2.17699890
75Depression (HP:0000716)2.15999037
76Absent speech (HP:0001344)2.15384944
77Acute encephalopathy (HP:0006846)2.14311926
78Medial flaring of the eyebrow (HP:0010747)2.13180511
79Abnormality of salivation (HP:0100755)2.12659651
80Ulnar claw (HP:0001178)2.12177025
81Shoulder girdle muscle weakness (HP:0003547)2.12013631
82Molar tooth sign on MRI (HP:0002419)2.09908881
83Abnormality of midbrain morphology (HP:0002418)2.09908881
84Nephronophthisis (HP:0000090)2.03894930
85Focal dystonia (HP:0004373)2.03139012
86Delusions (HP:0000746)2.02819614
87Inappropriate behavior (HP:0000719)2.02097414
88Abnormality of the lower motor neuron (HP:0002366)2.02057515
89Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.00982416
90Degeneration of the lateral corticospinal tracts (HP:0002314)2.00982416
91Narrow nasal bridge (HP:0000446)2.00878376
92Psychosis (HP:0000709)2.00799030
93Craniofacial dystonia (HP:0012179)1.99224398
94Megalencephaly (HP:0001355)1.97646992
95Congenital primary aphakia (HP:0007707)1.97315806
96Impaired social interactions (HP:0000735)1.96933043
97Abnormal social behavior (HP:0012433)1.96933043
98Myotonia (HP:0002486)1.96259222
99Hypoplasia of the corpus callosum (HP:0002079)1.96249497
100Dysdiadochokinesis (HP:0002075)1.95076968
101Abnormality of the labia minora (HP:0012880)1.93806431
102Protruding tongue (HP:0010808)1.91796592
103Sleep apnea (HP:0010535)1.91110345
104Genital tract atresia (HP:0001827)1.90161049
105Genetic anticipation (HP:0003743)1.88631581
106Optic disc pallor (HP:0000543)1.88480518
107Intellectual disability, severe (HP:0010864)1.87500021
108Abnormal ciliary motility (HP:0012262)1.87127544
109Sporadic (HP:0003745)1.86306511
110Bradykinesia (HP:0002067)1.86173673
111Lower limb muscle weakness (HP:0007340)1.85756851
112Dysmetria (HP:0001310)1.85706003
113Type II lissencephaly (HP:0007260)1.85084897
114Gaze-evoked nystagmus (HP:0000640)1.84577327
115Delayed gross motor development (HP:0002194)1.83862358
116Restlessness (HP:0000711)1.83246150
117Postural instability (HP:0002172)1.82756797
118Vaginal atresia (HP:0000148)1.82152546
119Muscular hypotonia of the trunk (HP:0008936)1.78682098
120Shawl scrotum (HP:0000049)1.77366897
121Spastic tetraparesis (HP:0001285)1.76443434
122Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.75918022
123Nephrogenic diabetes insipidus (HP:0009806)1.74043666
124Incomplete penetrance (HP:0003829)1.71395537
125True hermaphroditism (HP:0010459)1.70310019
126Hemiplegia (HP:0002301)1.70096735
127Peripheral hypomyelination (HP:0007182)1.69669553
128Oligodactyly (hands) (HP:0001180)1.69417157
129Polymicrogyria (HP:0002126)1.69244331
130Pancreatic fibrosis (HP:0100732)1.68886059
131Prolonged QT interval (HP:0001657)1.68731181

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.77328065
2NTRK33.36330796
3MAP3K93.17710697
4MAP3K43.01372860
5CASK2.97314646
6MAP3K122.94940060
7MINK12.82388967
8MAPK132.75032695
9NTRK22.70336291
10PNCK2.66547688
11MAP2K72.64582679
12EPHA42.24747133
13DYRK22.03939316
14SIK21.89974591
15MAP2K41.86553404
16GRK51.72003751
17PHKG11.69343929
18PHKG21.69343929
19UHMK11.67686559
20TNIK1.64970733
21PLK21.62480561
22DAPK21.58292717
23PINK11.48256553
24CSNK1G21.47256478
25KSR11.42409041
26NTRK11.42000578
27LATS21.41536510
28CDK51.38419799
29ARAF1.35780402
30PAK61.34426305
31NME11.33423217
32CSNK1G31.30830796
33GRK71.21006760
34ERBB31.13134610
35DAPK11.10326627
36PRKCG1.09645919
37DYRK1A1.05706992
38CAMK2A1.05662317
39CDK141.04619097
40CDK181.04066009
41WNK31.02581476
42FGR1.01755567
43CDK151.00291735
44LIMK10.98950845
45PAK30.98381651
46BCR0.91905890
47KSR20.91566617
48CAMK2B0.90389784
49CDK11A0.89706267
50CDK190.88472316
51PRKD30.88143525
52RIPK40.81247590
53CSNK1G10.80336186
54MAP3K110.76214152
55ADRBK10.76033982
56BMPR1B0.74183975
57FES0.73926335
58SGK20.73414561
59CSNK1A1L0.70993167
60MAP3K60.69441329
61TYRO30.69232235
62ADRBK20.69202716
63DYRK30.69174248
64MARK20.67771002
65DYRK1B0.66994262
66PKN10.65543867
67RPS6KA20.64222577
68PRKCZ0.64071334
69TRIM280.63714949
70CAMKK10.62021091
71STK110.59862268
72PRKCE0.59813410
73SIK30.58615608
74EPHA30.58025639
75PRKCH0.57946467
76RET0.57609447
77PRPF4B0.56899419
78OXSR10.54106125
79CAMKK20.52998254
80MAPK120.52621045
81CAMK1G0.52106924
82GRK60.51799590
83PTK2B0.49817812
84MAP4K20.49687943
85SGK2230.48592063
86SGK4940.48592063
87CAMK2D0.48043488
88MAPKAPK50.47205298
89MAPK40.45186014
90CAMK40.41385015
91STK160.41088246
92ALK0.38310423
93MAPK150.38237833
94ROCK20.37598304
95FYN0.37435941
96BMPR20.36868773
97MAPK90.36711891
98CSNK1D0.35961070
99SGK30.35590932
100CAMK2G0.35490809
101MAP3K20.34920046
102EPHB20.34880985
103PRKACA0.33984934
104SGK10.33903777
105MAP2K10.33531003
106RAF10.32086508
107CSNK1E0.32057563
108WNK40.31495419
109PRKACB0.30415256
110MAPK80.30019795
111ERBB20.28818424
112* PRKCB0.28662107
113PRKG10.28566574
114FER0.28121357
115RPS6KA30.27706309
116BRAF0.27676742
117CAMK10.27665213
118PRKAA10.27051135
119STK390.25890398
120PRKCA0.25835768
121PLK30.25437012
122GRK10.24450288
123CSNK1A10.24356387
124PRKACG0.24171252

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.09589949
2Synaptic vesicle cycle_Homo sapiens_hsa047213.21885175
3Oxidative phosphorylation_Homo sapiens_hsa001902.78411487
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.68788869
5GABAergic synapse_Homo sapiens_hsa047272.52772611
6Parkinsons disease_Homo sapiens_hsa050122.52213335
7Olfactory transduction_Homo sapiens_hsa047402.39181375
8Dopaminergic synapse_Homo sapiens_hsa047282.37868466
9Amphetamine addiction_Homo sapiens_hsa050312.32632426
10Glutamatergic synapse_Homo sapiens_hsa047242.31553103
11Circadian entrainment_Homo sapiens_hsa047132.29774023
12Long-term potentiation_Homo sapiens_hsa047202.27473758
13Morphine addiction_Homo sapiens_hsa050322.26623113
14Alzheimers disease_Homo sapiens_hsa050102.18405502
15Serotonergic synapse_Homo sapiens_hsa047262.14881878
16Cocaine addiction_Homo sapiens_hsa050302.08993866
17Collecting duct acid secretion_Homo sapiens_hsa049662.07595899
18Taste transduction_Homo sapiens_hsa047421.97093107
19Cholinergic synapse_Homo sapiens_hsa047251.91978714
20Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.82083003
21Cardiac muscle contraction_Homo sapiens_hsa042601.81436736
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.76980431
23Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.75722320
24Renin secretion_Homo sapiens_hsa049241.74159585
25Huntingtons disease_Homo sapiens_hsa050161.73563933
26Long-term depression_Homo sapiens_hsa047301.71321214
27Axon guidance_Homo sapiens_hsa043601.68159786
28Insulin secretion_Homo sapiens_hsa049111.60808592
29Salivary secretion_Homo sapiens_hsa049701.60320479
30Gap junction_Homo sapiens_hsa045401.56524677
31Gastric acid secretion_Homo sapiens_hsa049711.46324264
32Aldosterone synthesis and secretion_Homo sapiens_hsa049251.40268975
33Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.39361694
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.38918235
35Oxytocin signaling pathway_Homo sapiens_hsa049211.36572209
36Vibrio cholerae infection_Homo sapiens_hsa051101.33590238
37GnRH signaling pathway_Homo sapiens_hsa049121.31933182
38Calcium signaling pathway_Homo sapiens_hsa040201.30364477
39Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.25497044
40Phototransduction_Homo sapiens_hsa047441.21545941
41Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.15566570
42Estrogen signaling pathway_Homo sapiens_hsa049151.06784087
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.02639100
44Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.98642819
45Melanogenesis_Homo sapiens_hsa049160.96840023
46Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.95799046
47ErbB signaling pathway_Homo sapiens_hsa040120.94570804
48Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.93410708
49Alcoholism_Homo sapiens_hsa050340.84080485
50Oocyte meiosis_Homo sapiens_hsa041140.83126348
51cAMP signaling pathway_Homo sapiens_hsa040240.81368436
52Glioma_Homo sapiens_hsa052140.80817325
53Type II diabetes mellitus_Homo sapiens_hsa049300.72713538
54Steroid biosynthesis_Homo sapiens_hsa001000.69257956
55cGMP-PKG signaling pathway_Homo sapiens_hsa040220.68104219
56Vascular smooth muscle contraction_Homo sapiens_hsa042700.66568988
57Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.64872256
58Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.62639784
59Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.61236109
60Ether lipid metabolism_Homo sapiens_hsa005650.58565084
61Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.57643515
62MAPK signaling pathway_Homo sapiens_hsa040100.57578894
63Renal cell carcinoma_Homo sapiens_hsa052110.57281999
64Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.56869714
65Phagosome_Homo sapiens_hsa041450.55732054
66Prion diseases_Homo sapiens_hsa050200.55397351
67Carbohydrate digestion and absorption_Homo sapiens_hsa049730.55322849
68Dilated cardiomyopathy_Homo sapiens_hsa054140.53620568
69Dorso-ventral axis formation_Homo sapiens_hsa043200.53548554
70Neurotrophin signaling pathway_Homo sapiens_hsa047220.53001944
71Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.52554756
72Butanoate metabolism_Homo sapiens_hsa006500.52117563
73alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.52045880
74Bile secretion_Homo sapiens_hsa049760.51170821
75Ras signaling pathway_Homo sapiens_hsa040140.50364258
76Linoleic acid metabolism_Homo sapiens_hsa005910.50222090
77Phosphatidylinositol signaling system_Homo sapiens_hsa040700.50153140
78Colorectal cancer_Homo sapiens_hsa052100.48947264
79Hippo signaling pathway_Homo sapiens_hsa043900.47822450
80Thyroid hormone synthesis_Homo sapiens_hsa049180.46608840
81Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45865772
82Endometrial cancer_Homo sapiens_hsa052130.45849050
83Phospholipase D signaling pathway_Homo sapiens_hsa040720.45204313
84Sphingolipid signaling pathway_Homo sapiens_hsa040710.44169661
85Wnt signaling pathway_Homo sapiens_hsa043100.44079290
86Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.43877770
87African trypanosomiasis_Homo sapiens_hsa051430.43080597
88Pancreatic secretion_Homo sapiens_hsa049720.42929287
89Glucagon signaling pathway_Homo sapiens_hsa049220.42499806
90Protein export_Homo sapiens_hsa030600.41857931
91Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40329199
92Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.40325148
93VEGF signaling pathway_Homo sapiens_hsa043700.40165426
94Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.39779080
95Choline metabolism in cancer_Homo sapiens_hsa052310.39691145
96Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.39009495
97Insulin signaling pathway_Homo sapiens_hsa049100.36568011
98Rheumatoid arthritis_Homo sapiens_hsa053230.36223489
99Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.33330579
100Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.33253350
101Rap1 signaling pathway_Homo sapiens_hsa040150.32437379
102Basal cell carcinoma_Homo sapiens_hsa052170.31175044
103Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.30299063
104Regulation of autophagy_Homo sapiens_hsa041400.27908259
105Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.25848842
106Tryptophan metabolism_Homo sapiens_hsa003800.25328172
107Hedgehog signaling pathway_Homo sapiens_hsa043400.24564183
108Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.23928073
109Type I diabetes mellitus_Homo sapiens_hsa049400.21373897
110Ovarian steroidogenesis_Homo sapiens_hsa049130.21148087
111Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.20180604
112Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.20052728
113Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.19688722
114Proteasome_Homo sapiens_hsa030500.18658213
115SNARE interactions in vesicular transport_Homo sapiens_hsa041300.18616122
116Endocytosis_Homo sapiens_hsa041440.14616440

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