GAPDH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the glyceraldehyde-3-phosphate dehydrogenase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The product of this gene catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD). The encoded protein has additionally been identified to have uracil DNA glycosylase activity in the nucleus. Also, this protein contains a peptide that has antimicrobial activity against E. coli, P. aeruginosa, and C. albicans. Studies of a similar protein in mouse have assigned a variety of additional functions including nitrosylation of nuclear proteins, the regulation of mRNA stability, and acting as a transferrin receptor on the cell surface of macrophage. Many pseudogenes similar to this locus are present in the human genome. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.79238473
2IMP biosynthetic process (GO:0006188)4.82283998
3DNA strand elongation involved in DNA replication (GO:0006271)4.78776805
4DNA replication initiation (GO:0006270)4.75227110
5peptidyl-arginine omega-N-methylation (GO:0035247)4.74789200
6folic acid-containing compound biosynthetic process (GO:0009396)4.69266488
7regulation of gene silencing by RNA (GO:0060966)4.55777178
8regulation of posttranscriptional gene silencing (GO:0060147)4.55777178
9regulation of gene silencing by miRNA (GO:0060964)4.55777178
10L-serine metabolic process (GO:0006563)4.54820150
11DNA strand elongation (GO:0022616)4.49782072
12histone arginine methylation (GO:0034969)4.35101787
13mitotic chromosome condensation (GO:0007076)4.34812833
14IMP metabolic process (GO:0046040)4.25752271
15nucleobase biosynthetic process (GO:0046112)4.19256474
16mitotic nuclear envelope disassembly (GO:0007077)4.18056337
17establishment of integrated proviral latency (GO:0075713)4.15591395
18viral transcription (GO:0019083)4.15282918
19protein localization to kinetochore (GO:0034501)4.11639595
20formation of translation preinitiation complex (GO:0001731)4.11211429
21translational termination (GO:0006415)4.09543536
22regulation of translational fidelity (GO:0006450)4.06812990
23peptidyl-arginine methylation (GO:0018216)3.99878593
24peptidyl-arginine N-methylation (GO:0035246)3.99878593
25telomere maintenance via semi-conservative replication (GO:0032201)3.96730955
26maturation of SSU-rRNA (GO:0030490)3.95171342
27heterochromatin organization (GO:0070828)3.92354450
28nuclear pore organization (GO:0006999)3.91305073
29pre-miRNA processing (GO:0031054)3.89839418
30membrane disassembly (GO:0030397)3.87925649
31nuclear envelope disassembly (GO:0051081)3.87925649
32translational elongation (GO:0006414)3.86628019
33Golgi transport vesicle coating (GO:0048200)3.77653010
34COPI coating of Golgi vesicle (GO:0048205)3.77653010
35DNA replication checkpoint (GO:0000076)3.74640795
36paraxial mesoderm development (GO:0048339)3.72628646
37mitotic sister chromatid segregation (GO:0000070)3.69589805
38translational initiation (GO:0006413)3.67304465
39ribosomal small subunit assembly (GO:0000028)3.64359951
40DNA replication-dependent nucleosome assembly (GO:0006335)3.61562043
41DNA replication-dependent nucleosome organization (GO:0034723)3.61562043
42negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.57540143
43purine nucleobase biosynthetic process (GO:0009113)3.57206780
44nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.54221144
45regulation of translational termination (GO:0006449)3.51232917
46mitotic metaphase plate congression (GO:0007080)3.49512235
47cellular protein complex disassembly (GO:0043624)3.48921417
48ribosomal large subunit biogenesis (GO:0042273)3.42407422
49nuclear pore complex assembly (GO:0051292)3.39681584
50regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.39367234
51telomere maintenance via telomere lengthening (GO:0010833)3.39091989
52telomere maintenance via recombination (GO:0000722)3.38297673
53ribosome assembly (GO:0042255)3.36688144
54DNA duplex unwinding (GO:0032508)3.36505254
55DNA geometric change (GO:0032392)3.35272134
56spliceosomal snRNP assembly (GO:0000387)3.35075169
57protein complex disassembly (GO:0043241)3.31465441
58ribosomal small subunit biogenesis (GO:0042274)3.30680591
59protein maturation by protein folding (GO:0022417)3.30058398
60NADPH regeneration (GO:0006740)3.27652318
61sister chromatid segregation (GO:0000819)3.25249277
62protein localization to chromosome, centromeric region (GO:0071459)3.25191410
63viral life cycle (GO:0019058)3.22993073
64ribonucleoprotein complex biogenesis (GO:0022613)3.22819099
65mitotic recombination (GO:0006312)3.22092460
66ribosome biogenesis (GO:0042254)3.21819816
67negative regulation of RNA splicing (GO:0033119)3.20322056
68nodal signaling pathway (GO:0038092)3.18134228
69negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.14464023
70anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.12395796
71macromolecular complex disassembly (GO:0032984)3.11451804
72nucleotide-excision repair, DNA gap filling (GO:0006297)3.10031713
73* glycolytic process (GO:0006096)3.08829557
74mRNA splicing, via spliceosome (GO:0000398)3.07593787
75RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.07593787
76nuclear envelope reassembly (GO:0031468)3.07461987
77mitotic nuclear envelope reassembly (GO:0007084)3.07461987
78SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.07292324
79regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.06994350
80regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.06380351
81RNA splicing, via transesterification reactions (GO:0000375)3.05719173
82postreplication repair (GO:0006301)3.04844337
83regulation of protein heterodimerization activity (GO:0043497)3.03508057
84negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.99792485
85negative regulation of ligase activity (GO:0051352)2.99792485
86negative regulation of mRNA processing (GO:0050686)2.98499609
87spliceosomal tri-snRNP complex assembly (GO:0000244)2.98330629
88cotranslational protein targeting to membrane (GO:0006613)2.98108252
89protein targeting to ER (GO:0045047)2.98046628
90protein complex localization (GO:0031503)2.97297476
91nuclear envelope organization (GO:0006998)2.92960464
92positive regulation of SMAD protein import into nucleus (GO:0060391)2.92669829
93establishment of viral latency (GO:0019043)2.92338575
94tRNA aminoacylation for protein translation (GO:0006418)2.92066438
95proline biosynthetic process (GO:0006561)2.92063372
96spliceosomal complex assembly (GO:0000245)2.91763536
97metaphase plate congression (GO:0051310)2.91570646
98serine family amino acid biosynthetic process (GO:0009070)2.89446411
99somatic hypermutation of immunoglobulin genes (GO:0016446)2.87862659
100somatic diversification of immune receptors via somatic mutation (GO:0002566)2.87862659
101rRNA processing (GO:0006364)2.87142059
102tRNA aminoacylation (GO:0043039)2.85827600
103amino acid activation (GO:0043038)2.85827600
104positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.85267450
105establishment of protein localization to endoplasmic reticulum (GO:0072599)2.83287524
106double-strand break repair via nonhomologous end joining (GO:0006303)2.82811090
107non-recombinational repair (GO:0000726)2.82811090
108regulation of spindle organization (GO:0090224)2.81199805
109* gluconeogenesis (GO:0006094)2.80278233
110regulation of mitotic spindle organization (GO:0060236)2.79794879
111regulation of centrosome cycle (GO:0046605)2.79418304
112rRNA metabolic process (GO:0016072)2.76901115
113pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.75921713
114deoxyribonucleotide biosynthetic process (GO:0009263)2.75656875
115DNA ligation (GO:0006266)2.75003026
116glucose 6-phosphate metabolic process (GO:0051156)2.74766001
117establishment of chromosome localization (GO:0051303)2.73716922
118negative regulation of histone methylation (GO:0031061)2.72904048
119pentose-phosphate shunt (GO:0006098)2.72403485
120intra-S DNA damage checkpoint (GO:0031573)2.72239696
121pore complex assembly (GO:0046931)2.72013413
122protein localization to endoplasmic reticulum (GO:0070972)2.70784828
123nucleobase-containing small molecule interconversion (GO:0015949)2.69301316
124base-excision repair (GO:0006284)2.68904764
125cellular protein complex localization (GO:0034629)2.68833371
126chaperone-mediated protein complex assembly (GO:0051131)2.67326631
127proteasome assembly (GO:0043248)2.67208991
128chromosome condensation (GO:0030261)2.66304542
129G1/S transition of mitotic cell cycle (GO:0000082)2.64812749
130cell cycle G1/S phase transition (GO:0044843)2.64812749
131regulation of chromosome segregation (GO:0051983)2.64776049
132cullin deneddylation (GO:0010388)2.64772996
133glucose catabolic process (GO:0006007)2.63894784
134* monosaccharide biosynthetic process (GO:0046364)2.63750105
135DNA damage response, detection of DNA damage (GO:0042769)2.63655545
136CENP-A containing nucleosome assembly (GO:0034080)2.62773469
137DNA topological change (GO:0006265)2.61318861
138spindle checkpoint (GO:0031577)2.61071401
139chromatin remodeling at centromere (GO:0031055)2.61042329

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.50899608
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.48270510
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.23118068
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.98749286
5MYC_19079543_ChIP-ChIP_MESCs_Mouse3.43300287
6* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.33964116
7* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.84187284
8* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.81441340
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.70372512
10* XRN2_22483619_ChIP-Seq_HELA_Human2.63486872
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.49416459
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.45196217
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.42770159
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.40138674
15POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.34301079
16* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.23924464
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.15484305
18KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.13724589
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.09183867
20NANOG_18555785_ChIP-Seq_MESCs_Mouse2.07128577
21THAP11_20581084_ChIP-Seq_MESCs_Mouse2.05406762
22* MYC_22102868_ChIP-Seq_BL_Human2.04245114
23* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.98813344
24E2F1_18555785_ChIP-Seq_MESCs_Mouse1.96834926
25MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.96035093
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.91005517
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.90889045
28AR_21909140_ChIP-Seq_LNCAP_Human1.87341644
29* TTF2_22483619_ChIP-Seq_HELA_Human1.85647005
30ZNF263_19887448_ChIP-Seq_K562_Human1.83481076
31E2F1_21310950_ChIP-Seq_MCF-7_Human1.83289317
32SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.80778700
33MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.77863992
34MYCN_18555785_ChIP-Seq_MESCs_Mouse1.77731253
35POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.77539112
36GABP_17652178_ChIP-ChIP_JURKAT_Human1.75696883
37CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.74952337
38ESR1_15608294_ChIP-ChIP_MCF-7_Human1.70211421
39DCP1A_22483619_ChIP-Seq_HELA_Human1.68778141
40CIITA_25753668_ChIP-Seq_RAJI_Human1.68424102
41KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.65149363
42GABP_19822575_ChIP-Seq_HepG2_Human1.59864785
43ZFX_18555785_ChIP-Seq_MESCs_Mouse1.58105906
44NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.56818678
45YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.56107124
46* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.55429419
47FOXP3_21729870_ChIP-Seq_TREG_Human1.55329844
48ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.55008331
49STAT3_1855785_ChIP-Seq_MESCs_Mouse1.54654557
50VDR_23849224_ChIP-Seq_CD4+_Human1.53375566
51TCF3_18692474_ChIP-Seq_MEFs_Mouse1.51784464
52SOX2_18555785_ChIP-Seq_MESCs_Mouse1.51105606
53YY1_21170310_ChIP-Seq_MESCs_Mouse1.45509284
54TP63_17297297_ChIP-ChIP_HaCaT_Human1.44318871
55ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.41435474
56TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.38919516
57* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.36190887
58KDM5A_27292631_Chip-Seq_BREAST_Human1.34861155
59* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.34626180
60KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.31465582
61KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.31465582
62KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.31465582
63ZFP281_18757296_ChIP-ChIP_E14_Mouse1.31422161
64KLF4_18555785_ChIP-Seq_MESCs_Mouse1.28820775
65* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.28213810
66* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.27923513
67TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.27399449
68* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.27130552
69* VDR_21846776_ChIP-Seq_THP-1_Human1.26305730
70TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.24764419
71PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24214149
72HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.24137558
73ELF1_17652178_ChIP-ChIP_JURKAT_Human1.22314751
74* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21145398
75CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.20560024
76NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.20261687
77DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.20063414
78FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.19922074
79PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.19137526
80SRF_21415370_ChIP-Seq_HL-1_Mouse1.18091673
81PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.18049058
82* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.17570999
83* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.17044703
84CLOCK_20551151_ChIP-Seq_293T_Human1.15211461
85PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.14803920
86NANOG_21062744_ChIP-ChIP_HESCs_Human1.13727142
87* HIF1A_21447827_ChIP-Seq_MCF-7_Human1.13630199
88* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.12768154
89TFEB_21752829_ChIP-Seq_HELA_Human1.12759512
90HOXB4_20404135_ChIP-ChIP_EML_Mouse1.10449755
91DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.08023780
92ERG_20887958_ChIP-Seq_HPC-7_Mouse1.06906873
93SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.05767206
94SOX17_20123909_ChIP-Seq_XEN_Mouse1.05661323
95* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.05568065
96SRY_22984422_ChIP-ChIP_TESTIS_Rat1.04069290
97* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.03792380
98* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.03202574
99SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.02762796
100* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02040066
101SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.01389134
102TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00940122
103TCF3_18692474_ChIP-Seq_MESCs_Mouse1.00534677
104SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.98029119
105SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.97449756
106E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.97324010
107PADI4_21655091_ChIP-ChIP_MCF-7_Human0.97117847
108BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.96695411
109PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.96324283
110TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.96160163
111TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.95665639
112* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.95490804
113* ATF3_27146783_Chip-Seq_COLON_Human0.95114549
114SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.94695298
115RBPJ_22232070_ChIP-Seq_NCS_Mouse0.94659890
116TBX5_21415370_ChIP-Seq_HL-1_Mouse0.93735077
117POU5F1_16518401_ChIP-PET_MESCs_Mouse0.92745297
118ELK1_19687146_ChIP-ChIP_HELA_Human0.91779033
119TP63_19390658_ChIP-ChIP_HaCaT_Human0.91414004
120MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.90369143
121NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.87796388
122* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.87376685
123FOXP1_21924763_ChIP-Seq_HESCs_Human0.86760098
124* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.86645485
125ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.85950013

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004957_abnormal_blastocyst_morpholog4.02008606
2MP0003693_abnormal_embryo_hatching3.97311259
3MP0010094_abnormal_chromosome_stability3.81965544
4MP0003111_abnormal_nucleus_morphology3.80075381
5MP0003077_abnormal_cell_cycle3.41730949
6MP0003123_paternal_imprinting3.23400577
7MP0001730_embryonic_growth_arrest2.75809782
8MP0010030_abnormal_orbit_morphology2.69789595
9MP0008932_abnormal_embryonic_tissue2.61999166
10MP0002877_abnormal_melanocyte_morpholog2.61488305
11MP0002653_abnormal_ependyma_morphology2.58855107
12MP0008007_abnormal_cellular_replicative2.50554456
13MP0010352_gastrointestinal_tract_polyps2.37651831
14MP0008057_abnormal_DNA_replication2.31216970
15MP0000350_abnormal_cell_proliferation2.29135926
16MP0004133_heterotaxia2.27299808
17MP0004233_abnormal_muscle_weight2.18571599
18MP0008058_abnormal_DNA_repair2.08350776
19MP0001697_abnormal_embryo_size2.04440401
20MP0002084_abnormal_developmental_patter1.92190457
21MP0005380_embryogenesis_phenotype1.91500228
22MP0001672_abnormal_embryogenesis/_devel1.91500228
23MP0002085_abnormal_embryonic_tissue1.89700960
24MP0004084_abnormal_cardiac_muscle1.86024164
25MP0003283_abnormal_digestive_organ1.84494838
26MP0005076_abnormal_cell_differentiation1.84136674
27MP0003119_abnormal_digestive_system1.82534623
28MP0003121_genomic_imprinting1.81664164
29MP0003984_embryonic_growth_retardation1.81624214
30MP0000537_abnormal_urethra_morphology1.79785189
31* MP0002080_prenatal_lethality1.77750876
32MP0002088_abnormal_embryonic_growth/wei1.77295975
33MP0004272_abnormal_basement_membrane1.74925200
34MP0004197_abnormal_fetal_growth/weight/1.70532881
35MP0010307_abnormal_tumor_latency1.69709976
36MP0003122_maternal_imprinting1.63390815
37MP0009053_abnormal_anal_canal1.62472327
38MP0003890_abnormal_embryonic-extraembry1.59055481
39MP0008877_abnormal_DNA_methylation1.53542056
40MP0001293_anophthalmia1.51677906
41MP0003567_abnormal_fetal_cardiomyocyte1.48803402
42MP0008438_abnormal_cutaneous_collagen1.46519312
43MP0000579_abnormal_nail_morphology1.45392180
44MP0002086_abnormal_extraembryonic_tissu1.44754929
45MP0003705_abnormal_hypodermis_morpholog1.42866628
46MP0002938_white_spotting1.37524157
47MP0000750_abnormal_muscle_regeneration1.37021855
48MP0000762_abnormal_tongue_morphology1.31337688
49MP0005501_abnormal_skin_physiology1.31066842
50MP0009672_abnormal_birth_weight1.29022406
51MP0000313_abnormal_cell_death1.26739588
52MP0005257_abnormal_intraocular_pressure1.25332703
53MP0002269_muscular_atrophy1.18807135
54MP0004858_abnormal_nervous_system1.17665343
55MP0003950_abnormal_plasma_membrane1.17645909
56MP0003941_abnormal_skin_development1.17309285
57MP0003566_abnormal_cell_adhesion1.17164345
58MP0003937_abnormal_limbs/digits/tail_de1.15647288
59MP0001346_abnormal_lacrimal_gland1.15413306
60MP0003186_abnormal_redox_activity1.15078584
61MP0009697_abnormal_copulation1.13166555
62MP0003646_muscle_fatigue1.12191801
63MP0006035_abnormal_mitochondrial_morpho1.12161780
64MP0010234_abnormal_vibrissa_follicle1.11681230
65MP0002234_abnormal_pharynx_morphology1.09091193
66MP0008260_abnormal_autophagy1.05325320
67MP0003221_abnormal_cardiomyocyte_apopto1.04403588
68MP0001299_abnormal_eye_distance/1.04332325
69MP0003718_maternal_effect1.04278620
70MP0005623_abnormal_meninges_morphology1.03277768
71MP0006292_abnormal_olfactory_placode1.02540027
72MP0000358_abnormal_cell_content/1.01259404
73MP0001661_extended_life_span0.98383062
74MP0005171_absent_coat_pigmentation0.98011852
75MP0002089_abnormal_postnatal_growth/wei0.97524961
76MP0003755_abnormal_palate_morphology0.97104575
77MP0005266_abnormal_metabolism0.96650660
78MP0000751_myopathy0.95999804
79MP0003861_abnormal_nervous_system0.95950439
80MP0000428_abnormal_craniofacial_morphol0.95849570
81MP0002060_abnormal_skin_morphology0.95712546
82MP0001849_ear_inflammation0.95398397
83MP0002019_abnormal_tumor_incidence0.93164767
84MP0000490_abnormal_crypts_of0.93010999
85MP0002092_abnormal_eye_morphology0.92623352
86MP0003385_abnormal_body_wall0.91829668
87MP0000003_abnormal_adipose_tissue0.91687894
88MP0008775_abnormal_heart_ventricle0.90875264
89MP0002111_abnormal_tail_morphology0.90502754
90MP0003806_abnormal_nucleotide_metabolis0.89808097
91MP0006072_abnormal_retinal_apoptosis0.87949313
92MP0005451_abnormal_body_composition0.85589582
93MP0003115_abnormal_respiratory_system0.85379222
94MP0009379_abnormal_foot_pigmentation0.84919581
95MP0002233_abnormal_nose_morphology0.84628072
96MP0004087_abnormal_muscle_fiber0.84600772
97MP0002163_abnormal_gland_morphology0.84467726
98MP0005197_abnormal_uvea_morphology0.84065444
99MP0003786_premature_aging0.83648321
100MP0004036_abnormal_muscle_relaxation0.83543144
101MP0009703_decreased_birth_body0.83385862
102MP0010630_abnormal_cardiac_muscle0.83035111
103MP0005384_cellular_phenotype0.82721642
104MP0000733_abnormal_muscle_development0.82310001
105MP0002697_abnormal_eye_size0.79656893
106MP0000534_abnormal_ureter_morphology0.79125491
107MP0005394_taste/olfaction_phenotype0.78982473
108MP0005499_abnormal_olfactory_system0.78982473
109MP0004808_abnormal_hematopoietic_stem0.78785661
110MP0000566_synostosis0.77351472
111MP0002396_abnormal_hematopoietic_system0.77079187
112MP0000266_abnormal_heart_morphology0.77045568
113MP0002796_impaired_skin_barrier0.76637597
114MP0000749_muscle_degeneration0.76513585
115MP0000858_altered_metastatic_potential0.76468455
116MP0001286_abnormal_eye_development0.76259735
117MP0000747_muscle_weakness0.75877224
118MP0002127_abnormal_cardiovascular_syste0.75511862
119MP0008789_abnormal_olfactory_epithelium0.75211760
120MP0002925_abnormal_cardiovascular_devel0.74706728
121MP0000467_abnormal_esophagus_morphology0.74611963
122MP0004215_abnormal_myocardial_fiber0.72399536
123MP0001348_abnormal_lacrimal_gland0.72226196
124* MP0008770_decreased_survivor_rate0.72114016
125MP0005621_abnormal_cell_physiology0.71041175
126MP0003315_abnormal_perineum_morphology0.71040592
127MP0000759_abnormal_skeletal_muscle0.70381925
128MP0000049_abnormal_middle_ear0.68829231
129MP0002751_abnormal_autonomic_nervous0.68506402
130MP0005023_abnormal_wound_healing0.67544078
131MP0002106_abnormal_muscle_physiology0.66988686
132MP0001529_abnormal_vocalization0.66367631
133MP0003942_abnormal_urinary_system0.66020394
134MP0002332_abnormal_exercise_endurance0.62551083
135MP0001915_intracranial_hemorrhage0.61945566

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)4.50764904
2Selective tooth agenesis (HP:0001592)3.66243182
3Abnormality of the labia minora (HP:0012880)3.62132438
4Reticulocytopenia (HP:0001896)3.54835952
5Abdominal situs inversus (HP:0003363)3.41324961
6Abnormality of abdominal situs (HP:0011620)3.41324961
7Chromosomal breakage induced by crosslinking agents (HP:0003221)3.39685480
8Colon cancer (HP:0003003)3.33242659
9Abnormal number of incisors (HP:0011064)3.33142953
10Birth length less than 3rd percentile (HP:0003561)3.19730157
11Medulloblastoma (HP:0002885)3.17871598
12Astrocytoma (HP:0009592)3.15879906
13Abnormality of the astrocytes (HP:0100707)3.15879906
14Agnosia (HP:0010524)3.09268786
15Exercise-induced muscle cramps (HP:0003710)3.00819254
16Adenoma sebaceum (HP:0009720)2.99288621
17Angiofibromas (HP:0010615)2.99288621
18Oral leukoplakia (HP:0002745)2.98715747
19Microvesicular hepatic steatosis (HP:0001414)2.92242160
20Abnormality of the anterior horn cell (HP:0006802)2.81117064
21Degeneration of anterior horn cells (HP:0002398)2.81117064
22Hypoplasia of the capital femoral epiphysis (HP:0003090)2.75646892
23Cortical dysplasia (HP:0002539)2.70836291
24Congenital stationary night blindness (HP:0007642)2.66686135
25Premature rupture of membranes (HP:0001788)2.63984119
26Breast hypoplasia (HP:0003187)2.63129160
27Trismus (HP:0000211)2.62113301
28Abnormal gallbladder physiology (HP:0012438)2.54209565
29Cholecystitis (HP:0001082)2.54209565
30Insomnia (HP:0100785)2.52416984
31Deviation of the thumb (HP:0009603)2.49314768
32Increased serum pyruvate (HP:0003542)2.48308722
33Abnormality of glycolysis (HP:0004366)2.48308722
34Rhabdomyosarcoma (HP:0002859)2.48159624
35Proximal placement of thumb (HP:0009623)2.46206984
36Glioma (HP:0009733)2.41362712
37Absent radius (HP:0003974)2.39993028
38Absent epiphyses (HP:0010577)2.39096389
39Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.39096389
40Absent thumb (HP:0009777)2.36505897
41Increased nuchal translucency (HP:0010880)2.36189669
42Patellar aplasia (HP:0006443)2.34354266
43Long palpebral fissure (HP:0000637)2.33718752
44Cerebral hypomyelination (HP:0006808)2.32959235
45Septo-optic dysplasia (HP:0100842)2.32369785
46Pterygium (HP:0001059)2.30884299
47Carpal bone hypoplasia (HP:0001498)2.27860621
48Upper limb muscle weakness (HP:0003484)2.27841511
49Neoplasm of striated muscle (HP:0009728)2.27764054
50Abnormality of the umbilical cord (HP:0010881)2.27166917
51Spastic diplegia (HP:0001264)2.26272500
52Absent forearm bone (HP:0003953)2.25796953
53Aplasia involving forearm bones (HP:0009822)2.25796953
54Rhabdomyolysis (HP:0003201)2.25098813
55Missing ribs (HP:0000921)2.22992339
56Atresia of the external auditory canal (HP:0000413)2.22587393
57Supernumerary spleens (HP:0009799)2.21842362
58Neoplasm of the pancreas (HP:0002894)2.20759052
59Basal cell carcinoma (HP:0002671)2.17198274
60Abnormality of reticulocytes (HP:0004312)2.16930079
61Abnormality of cells of the erythroid lineage (HP:0012130)2.16239664
62Tracheoesophageal fistula (HP:0002575)2.16048711
63Entropion (HP:0000621)2.14890573
64Overriding aorta (HP:0002623)2.14735111
65Aplasia/Hypoplasia of the patella (HP:0006498)2.14571903
66Postnatal microcephaly (HP:0005484)2.12363137
67Microglossia (HP:0000171)2.12023796
68Pointed chin (HP:0000307)2.11115395
69Aplasia/hypoplasia of the humerus (HP:0006507)2.10447282
70Renal duplication (HP:0000075)2.09157424
71Neoplasm of the oral cavity (HP:0100649)2.09014711
72Horseshoe kidney (HP:0000085)2.08416366
73Abnormality of the preputium (HP:0100587)2.07294343
74Myoglobinuria (HP:0002913)2.06995614
75Squamous cell carcinoma (HP:0002860)2.05702107
76Progressive muscle weakness (HP:0003323)2.04029895
77Shoulder girdle muscle weakness (HP:0003547)2.04018858
78Hyperacusis (HP:0010780)2.02825998
79Cholelithiasis (HP:0001081)2.02684255
80Macrocytic anemia (HP:0001972)2.00887563
81Rough bone trabeculation (HP:0100670)2.00374424
82Preauricular skin tag (HP:0000384)2.00096832
83Pelvic girdle muscle weakness (HP:0003749)1.97869108
84Prominent metopic ridge (HP:0005487)1.95510057
85Emotional lability (HP:0000712)1.94973394
86Skin tags (HP:0010609)1.92175271
87Severe visual impairment (HP:0001141)1.90941449
88Aplasia/Hypoplasia of the sacrum (HP:0008517)1.89607303
89Aplasia/Hypoplasia of the sternum (HP:0006714)1.88246622
90Abnormalities of placenta or umbilical cord (HP:0001194)1.87505344
91Poikiloderma (HP:0001029)1.86900016
92Broad distal phalanx of finger (HP:0009836)1.86319008
93Maternal diabetes (HP:0009800)1.85611913
94Multiple enchondromatosis (HP:0005701)1.85141284
95Abnormal lung lobation (HP:0002101)1.85133275
96Atrophy/Degeneration involving motor neurons (HP:0007373)1.84687836
97High anterior hairline (HP:0009890)1.84510059
98Meckel diverticulum (HP:0002245)1.83938835
99Hypoplastic pelvis (HP:0008839)1.83265193
100Abnormality of the lower motor neuron (HP:0002366)1.81976606
101Short nail (HP:0001799)1.81597477
102Aplasia/Hypoplasia of the spleen (HP:0010451)1.80986643
103Aplastic anemia (HP:0001915)1.80564590
104Elfin facies (HP:0004428)1.79826802
105Ovarian neoplasm (HP:0100615)1.79460107
106Limb-girdle muscle atrophy (HP:0003797)1.79130492
107Breast aplasia (HP:0100783)1.79007503
108Short humerus (HP:0005792)1.78763072
109Neuroblastoma (HP:0003006)1.78327688
110Primitive neuroectodermal tumor (HP:0030065)1.78327688
111Neuroblastic tumors (HP:0004376)1.78327688
112Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.78327688
113Asplenia (HP:0001746)1.78270969
114Unsteady gait (HP:0002317)1.77594112
115Freckling (HP:0001480)1.76385447
116Trigonocephaly (HP:0000243)1.76234184
117Chromsome breakage (HP:0040012)1.75861442
118Abnormal number of erythroid precursors (HP:0012131)1.75615270
119Biliary tract neoplasm (HP:0100574)1.75393345
120Abnormal gallbladder morphology (HP:0012437)1.75363400
121Pallor (HP:0000980)1.75314406
122Cleft eyelid (HP:0000625)1.75219735
123Abnormality of the ileum (HP:0001549)1.75139736
124Esophageal atresia (HP:0002032)1.74836569
125Anophthalmia (HP:0000528)1.74057805
126Intestinal polyp (HP:0005266)1.73649090
127Abnormality of the calcaneus (HP:0008364)1.73346415
128Small intestinal stenosis (HP:0012848)1.73331853
129Duodenal stenosis (HP:0100867)1.73331853
130Glossoptosis (HP:0000162)1.72588426
131Facial cleft (HP:0002006)1.72249232
132Cellular immunodeficiency (HP:0005374)1.70955927
133Pseudobulbar signs (HP:0002200)1.70955214
134Adducted thumb (HP:0001181)1.70861405
135Abnormality of the metopic suture (HP:0005556)1.70600369
136Generalized hypotonia (HP:0001290)1.70200113
137Slender long bone (HP:0003100)1.69487830
138Vertebral compression fractures (HP:0002953)1.68330198
139Secondary amenorrhea (HP:0000869)1.67945629
140Abnormality of the carotid arteries (HP:0005344)1.67776223
141Fibroma (HP:0010614)1.67004962
142Exercise intolerance (HP:0003546)1.66196700
143Calcaneovalgus deformity (HP:0001848)1.66161004
144Distal upper limb amyotrophy (HP:0007149)1.66085293
145Upper limb amyotrophy (HP:0009129)1.66085293
146Breech presentation (HP:0001623)1.65654670
147Aplasia/Hypoplasia of the uvula (HP:0010293)1.63454429
148Ulnar bowing (HP:0003031)1.62397496
149Small epiphyses (HP:0010585)1.62133386
150Progressive external ophthalmoplegia (HP:0000590)1.61091981
151Hand muscle atrophy (HP:0009130)1.61083724
152Achilles tendon contracture (HP:0001771)1.60666102
153Aplasia/Hypoplasia of the breasts (HP:0010311)1.56429341
154Distal lower limb amyotrophy (HP:0008944)1.55033839
155Abnormality of the gallbladder (HP:0005264)1.54696583
156Nephroblastoma (Wilms tumor) (HP:0002667)1.52010779
157Natal tooth (HP:0000695)1.51134400
158Deformed tarsal bones (HP:0008119)1.50544197
159Overlapping toe (HP:0001845)1.46317835
160Abnormal mitochondria in muscle tissue (HP:0008316)1.44009639
161Abnormality of chromosome stability (HP:0003220)1.43804291
162Flattened epiphyses (HP:0003071)1.43201705

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NEK14.75677743
2CDC73.99300492
3BUB13.54027013
4VRK23.41762978
5WEE13.34284697
6TSSK63.23477998
7PKN22.97429801
8TESK22.90900788
9SMG12.62261180
10NEK22.49507683
11EIF2AK12.47504320
12EEF2K2.36923082
13CDK122.34050696
14RPS6KB22.04417473
15TRIM281.90959728
16PASK1.86812083
17PAK41.79256869
18TESK11.78670338
19TTK1.68621252
20CDK71.61680276
21ALK1.60405411
22SCYL21.54758891
23PLK11.48626793
24MAP3K81.46702452
25IRAK31.43666900
26FLT31.41406243
27TLK11.40671173
28PLK31.37425858
29ATR1.35395009
30ERBB41.31759697
31TAF11.31194820
32MST1R1.31052275
33EPHA21.28237436
34ICK1.26358656
35AURKB1.21348965
36TRIB31.21016399
37BRD41.20922756
38ARAF1.20799512
39SIK31.20084243
40TGFBR11.15467819
41NME21.15381853
42BCKDK1.14718878
43STK161.14503296
44CHEK11.10907481
45LMTK21.09800696
46CDK41.09685857
47LIMK11.08565050
48LATS21.06339613
49SRPK11.04934063
50MAP3K101.04106355
51AURKA1.03282120
52MET1.02866785
53TTN1.01773593
54PTK21.01608778
55LRRK21.00306552
56FGFR10.99678844
57MKNK10.96869689
58BRSK10.96081575
59CDK190.95540263
60DAPK10.90999468
61NME10.90892448
62DAPK30.90653698
63NTRK10.86355721
64PDK20.83016775
65MAP3K110.82883781
66CDK20.81644502
67PAK10.81405874
68ILK0.79634682
69KSR10.78286915
70KSR20.78084787
71MAP3K90.77678064
72BMX0.76449434
73TAOK20.76206556
74BRSK20.75696112
75MINK10.75360988
76MOS0.75350317
77PLK40.73992239
78BCR0.73507737
79CHEK20.73007258
80CDK140.71763073
81RPS6KA40.71006142
82STK100.68999482
83CDK11A0.67130983
84CDK180.66704193
85CDK150.66375826
86VRK10.65934550
87CCNB10.65279381
88PDGFRA0.64502368
89PNCK0.63069936
90ATM0.61920580
91CSNK1E0.58942393
92MTOR0.57583094
93BRAF0.57050812
94CSNK2A20.56922648
95CDK60.56235215
96CDK80.56207315
97MAP2K30.55883765
98EIF2AK20.55830330
99EIF2AK30.54679054
100PAK60.54544388
101EPHB20.54415958
102CDK10.54072374
103MAPKAPK30.53301533
104CSNK1G30.52096560
105ACVR1B0.51107775
106KDR0.50520470
107SIK10.47663082
108DYRK30.46301169
109STK40.45993694
110CSNK2A10.44025481
111UHMK10.43404203
112PRKCI0.42768540
113CDK90.42654178
114RIPK10.40601565
115ZAK0.39639606
116PDK40.39384396
117PDK30.39384396
118DYRK20.39335082
119* AKT20.39097007
120PRKDC0.39032809
121PBK0.38254835
122PRKD30.35783585
123MKNK20.33074915
124STK38L0.31484458
125ROCK20.30917608
126PAK20.30713126
127PIM20.30536344

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.72129695
2Mismatch repair_Homo sapiens_hsa034303.90368966
3Spliceosome_Homo sapiens_hsa030403.24105247
4Ribosome_Homo sapiens_hsa030103.22816861
5One carbon pool by folate_Homo sapiens_hsa006702.94153565
6RNA transport_Homo sapiens_hsa030132.92366047
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.91222042
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.78562292
9Base excision repair_Homo sapiens_hsa034102.56811160
10Proteasome_Homo sapiens_hsa030502.38920943
11Cell cycle_Homo sapiens_hsa041102.35349710
12Nucleotide excision repair_Homo sapiens_hsa034202.26904813
13* Biosynthesis of amino acids_Homo sapiens_hsa012302.23317177
14Homologous recombination_Homo sapiens_hsa034402.15686006
15RNA polymerase_Homo sapiens_hsa030202.13481786
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.12304747
17Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.01935490
18* Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.84843266
19Vitamin B6 metabolism_Homo sapiens_hsa007501.79788360
20mRNA surveillance pathway_Homo sapiens_hsa030151.72313719
21Pyrimidine metabolism_Homo sapiens_hsa002401.71275562
22* Carbon metabolism_Homo sapiens_hsa012001.60610691
23RNA degradation_Homo sapiens_hsa030181.56626176
24Cyanoamino acid metabolism_Homo sapiens_hsa004601.56552002
25Central carbon metabolism in cancer_Homo sapiens_hsa052301.43562351
26Pentose phosphate pathway_Homo sapiens_hsa000301.32590815
27Oocyte meiosis_Homo sapiens_hsa041141.29702822
28Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.29009565
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.28817139
30Fanconi anemia pathway_Homo sapiens_hsa034601.27496402
31Fructose and mannose metabolism_Homo sapiens_hsa000511.27094186
32Fatty acid elongation_Homo sapiens_hsa000621.25899857
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.21757750
34Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.21389864
35Non-homologous end-joining_Homo sapiens_hsa034501.20520492
36Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.13637103
37p53 signaling pathway_Homo sapiens_hsa041151.12785127
38Steroid biosynthesis_Homo sapiens_hsa001001.08853376
39Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.08574802
40Synaptic vesicle cycle_Homo sapiens_hsa047211.00414104
41Basal cell carcinoma_Homo sapiens_hsa052171.00210365
42Parkinsons disease_Homo sapiens_hsa050120.99156882
43* HIF-1 signaling pathway_Homo sapiens_hsa040660.98779798
44Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.97936540
45Folate biosynthesis_Homo sapiens_hsa007900.97258612
46Purine metabolism_Homo sapiens_hsa002300.96512224
47Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.96508453
48Cardiac muscle contraction_Homo sapiens_hsa042600.95543386
49Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.93679446
50Glutathione metabolism_Homo sapiens_hsa004800.93164434
51Epstein-Barr virus infection_Homo sapiens_hsa051690.90778301
52Hippo signaling pathway_Homo sapiens_hsa043900.90571250
53Bladder cancer_Homo sapiens_hsa052190.89979950
54Galactose metabolism_Homo sapiens_hsa000520.88397127
55N-Glycan biosynthesis_Homo sapiens_hsa005100.88321965
56Thyroid cancer_Homo sapiens_hsa052160.86653031
57Protein export_Homo sapiens_hsa030600.86408044
58Huntingtons disease_Homo sapiens_hsa050160.86157132
59Arginine and proline metabolism_Homo sapiens_hsa003300.79015757
60Oxidative phosphorylation_Homo sapiens_hsa001900.76886993
61HTLV-I infection_Homo sapiens_hsa051660.76626976
62Pyruvate metabolism_Homo sapiens_hsa006200.73214091
63Propanoate metabolism_Homo sapiens_hsa006400.72766608
64Basal transcription factors_Homo sapiens_hsa030220.72006663
65Viral carcinogenesis_Homo sapiens_hsa052030.71562169
66Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.69112142
67Hedgehog signaling pathway_Homo sapiens_hsa043400.68464077
68Lysine degradation_Homo sapiens_hsa003100.67404283
69Selenocompound metabolism_Homo sapiens_hsa004500.64538008
70Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.60631116
71Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57819336
72MicroRNAs in cancer_Homo sapiens_hsa052060.53489076
73mTOR signaling pathway_Homo sapiens_hsa041500.52276778
74Tight junction_Homo sapiens_hsa045300.48762634
75Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.48727651
76Colorectal cancer_Homo sapiens_hsa052100.48278913
77Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.46977372
78Alcoholism_Homo sapiens_hsa050340.46302831
79Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.45881682
80Melanoma_Homo sapiens_hsa052180.45673625
81Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45556687
82Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.44222379
83Small cell lung cancer_Homo sapiens_hsa052220.44094181
84Dilated cardiomyopathy_Homo sapiens_hsa054140.43375465
85* Metabolic pathways_Homo sapiens_hsa011000.42423813
86Vibrio cholerae infection_Homo sapiens_hsa051100.41368106
87Systemic lupus erythematosus_Homo sapiens_hsa053220.41303678
88Thyroid hormone signaling pathway_Homo sapiens_hsa049190.40794543
89Glucagon signaling pathway_Homo sapiens_hsa049220.40775240
90Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.40232353
91Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.39987666
92Notch signaling pathway_Homo sapiens_hsa043300.38704278
93Gap junction_Homo sapiens_hsa045400.38395886
94Chronic myeloid leukemia_Homo sapiens_hsa052200.38114153
95Arginine biosynthesis_Homo sapiens_hsa002200.37305390
96Proteoglycans in cancer_Homo sapiens_hsa052050.37298262
97TGF-beta signaling pathway_Homo sapiens_hsa043500.37151781
98Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.36996664
99Fatty acid metabolism_Homo sapiens_hsa012120.36802293
100Adherens junction_Homo sapiens_hsa045200.36665105
101Wnt signaling pathway_Homo sapiens_hsa043100.36179737
102Glioma_Homo sapiens_hsa052140.35517420
103Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.35444626
104Melanogenesis_Homo sapiens_hsa049160.35382226
105Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.34236533
106Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.33213210
107Legionellosis_Homo sapiens_hsa051340.33124278
108Non-small cell lung cancer_Homo sapiens_hsa052230.32152816
109Pathways in cancer_Homo sapiens_hsa052000.31475653
110Antigen processing and presentation_Homo sapiens_hsa046120.30480135
111Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.29249763
112Neurotrophin signaling pathway_Homo sapiens_hsa047220.28856601
113Pancreatic cancer_Homo sapiens_hsa052120.28417943
114Collecting duct acid secretion_Homo sapiens_hsa049660.28032540
115Phototransduction_Homo sapiens_hsa047440.26781012
116Sulfur relay system_Homo sapiens_hsa041220.25836744
117Shigellosis_Homo sapiens_hsa051310.25003761
118Herpes simplex infection_Homo sapiens_hsa051680.24078034
119Long-term potentiation_Homo sapiens_hsa047200.24062667
120Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.23591524
121Prostate cancer_Homo sapiens_hsa052150.23051218
122Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.22791491
123Alzheimers disease_Homo sapiens_hsa050100.21968215
124Endometrial cancer_Homo sapiens_hsa052130.20548514
125Phenylalanine metabolism_Homo sapiens_hsa003600.20065281
126Renal cell carcinoma_Homo sapiens_hsa052110.18761779
127Acute myeloid leukemia_Homo sapiens_hsa052210.18734244
128Viral myocarditis_Homo sapiens_hsa054160.17867869

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »