Rank | Gene Set | Z-score |
---|---|---|
1 | DNA unwinding involved in DNA replication (GO:0006268) | 5.79238473 |
2 | IMP biosynthetic process (GO:0006188) | 4.82283998 |
3 | DNA strand elongation involved in DNA replication (GO:0006271) | 4.78776805 |
4 | DNA replication initiation (GO:0006270) | 4.75227110 |
5 | peptidyl-arginine omega-N-methylation (GO:0035247) | 4.74789200 |
6 | folic acid-containing compound biosynthetic process (GO:0009396) | 4.69266488 |
7 | regulation of posttranscriptional gene silencing (GO:0060147) | 4.55777178 |
8 | regulation of gene silencing by miRNA (GO:0060964) | 4.55777178 |
9 | regulation of gene silencing by RNA (GO:0060966) | 4.55777178 |
10 | L-serine metabolic process (GO:0006563) | 4.54820150 |
11 | DNA strand elongation (GO:0022616) | 4.49782072 |
12 | histone arginine methylation (GO:0034969) | 4.35101787 |
13 | mitotic chromosome condensation (GO:0007076) | 4.34812833 |
14 | IMP metabolic process (GO:0046040) | 4.25752271 |
15 | nucleobase biosynthetic process (GO:0046112) | 4.19256474 |
16 | mitotic nuclear envelope disassembly (GO:0007077) | 4.18056337 |
17 | establishment of integrated proviral latency (GO:0075713) | 4.15591395 |
18 | viral transcription (GO:0019083) | 4.15282918 |
19 | protein localization to kinetochore (GO:0034501) | 4.11639595 |
20 | formation of translation preinitiation complex (GO:0001731) | 4.11211429 |
21 | translational termination (GO:0006415) | 4.09543536 |
22 | regulation of translational fidelity (GO:0006450) | 4.06812990 |
23 | peptidyl-arginine N-methylation (GO:0035246) | 3.99878593 |
24 | peptidyl-arginine methylation (GO:0018216) | 3.99878593 |
25 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.96730955 |
26 | maturation of SSU-rRNA (GO:0030490) | 3.95171342 |
27 | heterochromatin organization (GO:0070828) | 3.92354450 |
28 | nuclear pore organization (GO:0006999) | 3.91305073 |
29 | pre-miRNA processing (GO:0031054) | 3.89839418 |
30 | nuclear envelope disassembly (GO:0051081) | 3.87925649 |
31 | membrane disassembly (GO:0030397) | 3.87925649 |
32 | translational elongation (GO:0006414) | 3.86628019 |
33 | COPI coating of Golgi vesicle (GO:0048205) | 3.77653010 |
34 | Golgi transport vesicle coating (GO:0048200) | 3.77653010 |
35 | DNA replication checkpoint (GO:0000076) | 3.74640795 |
36 | paraxial mesoderm development (GO:0048339) | 3.72628646 |
37 | mitotic sister chromatid segregation (GO:0000070) | 3.69589805 |
38 | translational initiation (GO:0006413) | 3.67304465 |
39 | ribosomal small subunit assembly (GO:0000028) | 3.64359951 |
40 | DNA replication-dependent nucleosome organization (GO:0034723) | 3.61562043 |
41 | DNA replication-dependent nucleosome assembly (GO:0006335) | 3.61562043 |
42 | negative regulation of mRNA splicing, via spliceosome (GO:0048025) | 3.57540143 |
43 | purine nucleobase biosynthetic process (GO:0009113) | 3.57206780 |
44 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 3.54221144 |
45 | regulation of translational termination (GO:0006449) | 3.51232917 |
46 | mitotic metaphase plate congression (GO:0007080) | 3.49512235 |
47 | cellular protein complex disassembly (GO:0043624) | 3.48921417 |
48 | ribosomal large subunit biogenesis (GO:0042273) | 3.42407422 |
49 | nuclear pore complex assembly (GO:0051292) | 3.39681584 |
50 | regulation of attachment of spindle microtubules to kinetochore (GO:0051988) | 3.39367234 |
51 | telomere maintenance via telomere lengthening (GO:0010833) | 3.39091989 |
52 | telomere maintenance via recombination (GO:0000722) | 3.38297673 |
53 | ribosome assembly (GO:0042255) | 3.36688144 |
54 | DNA duplex unwinding (GO:0032508) | 3.36505254 |
55 | DNA geometric change (GO:0032392) | 3.35272134 |
56 | spliceosomal snRNP assembly (GO:0000387) | 3.35075169 |
57 | protein complex disassembly (GO:0043241) | 3.31465441 |
58 | ribosomal small subunit biogenesis (GO:0042274) | 3.30680591 |
59 | protein maturation by protein folding (GO:0022417) | 3.30058398 |
60 | NADPH regeneration (GO:0006740) | 3.27652318 |
61 | sister chromatid segregation (GO:0000819) | 3.25249277 |
62 | protein localization to chromosome, centromeric region (GO:0071459) | 3.25191410 |
63 | viral life cycle (GO:0019058) | 3.22993073 |
64 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.22819099 |
65 | mitotic recombination (GO:0006312) | 3.22092460 |
66 | ribosome biogenesis (GO:0042254) | 3.21819816 |
67 | negative regulation of RNA splicing (GO:0033119) | 3.20322056 |
68 | nodal signaling pathway (GO:0038092) | 3.18134228 |
69 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.14464023 |
70 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.12395796 |
71 | macromolecular complex disassembly (GO:0032984) | 3.11451804 |
72 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 3.10031713 |
73 | * glycolytic process (GO:0006096) | 3.08829557 |
74 | mRNA splicing, via spliceosome (GO:0000398) | 3.07593787 |
75 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377) | 3.07593787 |
76 | nuclear envelope reassembly (GO:0031468) | 3.07461987 |
77 | mitotic nuclear envelope reassembly (GO:0007084) | 3.07461987 |
78 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 3.07292324 |
79 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.06994350 |
80 | regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083) | 3.06380351 |
81 | RNA splicing, via transesterification reactions (GO:0000375) | 3.05719173 |
82 | postreplication repair (GO:0006301) | 3.04844337 |
83 | regulation of protein heterodimerization activity (GO:0043497) | 3.03508057 |
84 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 2.99792485 |
85 | negative regulation of ligase activity (GO:0051352) | 2.99792485 |
86 | negative regulation of mRNA processing (GO:0050686) | 2.98499609 |
87 | spliceosomal tri-snRNP complex assembly (GO:0000244) | 2.98330629 |
88 | cotranslational protein targeting to membrane (GO:0006613) | 2.98108252 |
89 | protein targeting to ER (GO:0045047) | 2.98046628 |
90 | protein complex localization (GO:0031503) | 2.97297476 |
91 | nuclear envelope organization (GO:0006998) | 2.92960464 |
92 | positive regulation of SMAD protein import into nucleus (GO:0060391) | 2.92669829 |
93 | establishment of viral latency (GO:0019043) | 2.92338575 |
94 | tRNA aminoacylation for protein translation (GO:0006418) | 2.92066438 |
95 | proline biosynthetic process (GO:0006561) | 2.92063372 |
96 | spliceosomal complex assembly (GO:0000245) | 2.91763536 |
97 | metaphase plate congression (GO:0051310) | 2.91570646 |
98 | serine family amino acid biosynthetic process (GO:0009070) | 2.89446411 |
99 | somatic diversification of immune receptors via somatic mutation (GO:0002566) | 2.87862659 |
100 | somatic hypermutation of immunoglobulin genes (GO:0016446) | 2.87862659 |
101 | rRNA processing (GO:0006364) | 2.87142059 |
102 | amino acid activation (GO:0043038) | 2.85827600 |
103 | tRNA aminoacylation (GO:0043039) | 2.85827600 |
104 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 2.85267450 |
105 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 2.83287524 |
106 | non-recombinational repair (GO:0000726) | 2.82811090 |
107 | double-strand break repair via nonhomologous end joining (GO:0006303) | 2.82811090 |
108 | regulation of spindle organization (GO:0090224) | 2.81199805 |
109 | * gluconeogenesis (GO:0006094) | 2.80278233 |
110 | regulation of mitotic spindle organization (GO:0060236) | 2.79794879 |
111 | regulation of centrosome cycle (GO:0046605) | 2.79418304 |
112 | rRNA metabolic process (GO:0016072) | 2.76901115 |
113 | pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148) | 2.75921713 |
114 | deoxyribonucleotide biosynthetic process (GO:0009263) | 2.75656875 |
115 | DNA ligation (GO:0006266) | 2.75003026 |
116 | glucose 6-phosphate metabolic process (GO:0051156) | 2.74766001 |
117 | establishment of chromosome localization (GO:0051303) | 2.73716922 |
118 | negative regulation of histone methylation (GO:0031061) | 2.72904048 |
119 | pentose-phosphate shunt (GO:0006098) | 2.72403485 |
120 | intra-S DNA damage checkpoint (GO:0031573) | 2.72239696 |
121 | pore complex assembly (GO:0046931) | 2.72013413 |
122 | protein localization to endoplasmic reticulum (GO:0070972) | 2.70784828 |
123 | nucleobase-containing small molecule interconversion (GO:0015949) | 2.69301316 |
124 | base-excision repair (GO:0006284) | 2.68904764 |
125 | cellular protein complex localization (GO:0034629) | 2.68833371 |
126 | chaperone-mediated protein complex assembly (GO:0051131) | 2.67326631 |
127 | proteasome assembly (GO:0043248) | 2.67208991 |
128 | chromosome condensation (GO:0030261) | 2.66304542 |
129 | G1/S transition of mitotic cell cycle (GO:0000082) | 2.64812749 |
130 | cell cycle G1/S phase transition (GO:0044843) | 2.64812749 |
131 | regulation of chromosome segregation (GO:0051983) | 2.64776049 |
132 | cullin deneddylation (GO:0010388) | 2.64772996 |
133 | glucose catabolic process (GO:0006007) | 2.63894784 |
134 | * monosaccharide biosynthetic process (GO:0046364) | 2.63750105 |
135 | DNA damage response, detection of DNA damage (GO:0042769) | 2.63655545 |
136 | CENP-A containing nucleosome assembly (GO:0034080) | 2.62773469 |
137 | DNA topological change (GO:0006265) | 2.61318861 |
138 | spindle checkpoint (GO:0031577) | 2.61071401 |
139 | chromatin remodeling at centromere (GO:0031055) | 2.61042329 |
Rank | Gene Set | Z-score |
---|---|---|
1 | E2F7_22180533_ChIP-Seq_HELA_Human | 8.50899608 |
2 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.48270510 |
3 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 4.23118068 |
4 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 3.98749286 |
5 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 3.43300287 |
6 | * E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.33964116 |
7 | * MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.84187284 |
8 | * MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.81441340 |
9 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.70372512 |
10 | * XRN2_22483619_ChIP-Seq_HELA_Human | 2.63486872 |
11 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.49416459 |
12 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 2.45196217 |
13 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.42770159 |
14 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 2.40138674 |
15 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 2.34301079 |
16 | * NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.23924464 |
17 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.15484305 |
18 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 2.13724589 |
19 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.09183867 |
20 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 2.07128577 |
21 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.05406762 |
22 | * MYC_22102868_ChIP-Seq_BL_Human | 2.04245114 |
23 | * ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 1.98813344 |
24 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.96834926 |
25 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.96035093 |
26 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 1.91005517 |
27 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 1.90889045 |
28 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.87341644 |
29 | * TTF2_22483619_ChIP-Seq_HELA_Human | 1.85647005 |
30 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.83481076 |
31 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.83289317 |
32 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 1.80778700 |
33 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.77863992 |
34 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.77731253 |
35 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.77539112 |
36 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 1.75696883 |
37 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.74952337 |
38 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 1.70211421 |
39 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.68778141 |
40 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.68424102 |
41 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.65149363 |
42 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.59864785 |
43 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.58105906 |
44 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 1.56818678 |
45 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.56107124 |
46 | * POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.55429419 |
47 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.55329844 |
48 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.55008331 |
49 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.54654557 |
50 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.53375566 |
51 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 1.51784464 |
52 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.51105606 |
53 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.45509284 |
54 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 1.44318871 |
55 | ZIC3_20872845_ChIP-ChIP_MESCs_Mouse | 1.41435474 |
56 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.38919516 |
57 | * KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.36190887 |
58 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.34861155 |
59 | * KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 1.34626180 |
60 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 1.31465582 |
61 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 1.31465582 |
62 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 1.31465582 |
63 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 1.31422161 |
64 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.28820775 |
65 | * OCT4_18692474_ChIP-Seq_MEFs_Mouse | 1.28213810 |
66 | * NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 1.27923513 |
67 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.27399449 |
68 | * CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 1.27130552 |
69 | * VDR_21846776_ChIP-Seq_THP-1_Human | 1.26305730 |
70 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 1.24764419 |
71 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.24214149 |
72 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.24137558 |
73 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.22314751 |
74 | * TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.21145398 |
75 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 1.20560024 |
76 | NACC1_18358816_ChIP-ChIP_MESCs_Mouse | 1.20261687 |
77 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.20063414 |
78 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.19922074 |
79 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 1.19137526 |
80 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.18091673 |
81 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 1.18049058 |
82 | * HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 1.17570999 |
83 | * CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 1.17044703 |
84 | CLOCK_20551151_ChIP-Seq_293T_Human | 1.15211461 |
85 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 1.14803920 |
86 | NANOG_21062744_ChIP-ChIP_HESCs_Human | 1.13727142 |
87 | * HIF1A_21447827_ChIP-Seq_MCF-7_Human | 1.13630199 |
88 | * SOX2_18692474_ChIP-Seq_MEFs_Mouse | 1.12768154 |
89 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.12759512 |
90 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.10449755 |
91 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.08023780 |
92 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.06906873 |
93 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 1.05767206 |
94 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 1.05661323 |
95 | * SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 1.05568065 |
96 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.04069290 |
97 | * NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 1.03792380 |
98 | * CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 1.03202574 |
99 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.02762796 |
100 | * E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.02040066 |
101 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 1.01389134 |
102 | TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 1.00940122 |
103 | TCF3_18692474_ChIP-Seq_MESCs_Mouse | 1.00534677 |
104 | SALL4_18804426_ChIP-ChIP_MESCs_Mouse | 0.98029119 |
105 | SREBP1_19666523_ChIP-Seq_LIVER_Mouse | 0.97449756 |
106 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 0.97324010 |
107 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 0.97117847 |
108 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 0.96695411 |
109 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 0.96324283 |
110 | TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse | 0.96160163 |
111 | TRIM28_19339689_ChIP-ChIP_MESCs_Mouse | 0.95665639 |
112 | * SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 0.95490804 |
113 | * ATF3_27146783_Chip-Seq_COLON_Human | 0.95114549 |
114 | SOX2_18358816_ChIP-ChIP_MESCs_Mouse | 0.94695298 |
115 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 0.94659890 |
116 | TBX5_21415370_ChIP-Seq_HL-1_Mouse | 0.93735077 |
117 | POU5F1_16518401_ChIP-PET_MESCs_Mouse | 0.92745297 |
118 | ELK1_19687146_ChIP-ChIP_HELA_Human | 0.91779033 |
119 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 0.91414004 |
120 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 0.90369143 |
121 | NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 0.87796388 |
122 | * SOX2_18692474_ChIP-Seq_MESCs_Mouse | 0.87376685 |
123 | FOXP1_21924763_ChIP-Seq_HESCs_Human | 0.86760098 |
124 | * POU5F1_18692474_ChIP-Seq_MESCs_Mouse | 0.86645485 |
125 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 0.85950013 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0004957_abnormal_blastocyst_morpholog | 4.02008606 |
2 | MP0003693_abnormal_embryo_hatching | 3.97311259 |
3 | MP0010094_abnormal_chromosome_stability | 3.81965544 |
4 | MP0003111_abnormal_nucleus_morphology | 3.80075381 |
5 | MP0003077_abnormal_cell_cycle | 3.41730949 |
6 | MP0003123_paternal_imprinting | 3.23400577 |
7 | MP0001730_embryonic_growth_arrest | 2.75809782 |
8 | MP0010030_abnormal_orbit_morphology | 2.69789595 |
9 | MP0008932_abnormal_embryonic_tissue | 2.61999166 |
10 | MP0002877_abnormal_melanocyte_morpholog | 2.61488305 |
11 | MP0002653_abnormal_ependyma_morphology | 2.58855107 |
12 | MP0008007_abnormal_cellular_replicative | 2.50554456 |
13 | MP0010352_gastrointestinal_tract_polyps | 2.37651831 |
14 | MP0008057_abnormal_DNA_replication | 2.31216970 |
15 | MP0000350_abnormal_cell_proliferation | 2.29135926 |
16 | MP0004133_heterotaxia | 2.27299808 |
17 | MP0004233_abnormal_muscle_weight | 2.18571599 |
18 | MP0008058_abnormal_DNA_repair | 2.08350776 |
19 | MP0001697_abnormal_embryo_size | 2.04440401 |
20 | MP0002084_abnormal_developmental_patter | 1.92190457 |
21 | MP0001672_abnormal_embryogenesis/_devel | 1.91500228 |
22 | MP0005380_embryogenesis_phenotype | 1.91500228 |
23 | MP0002085_abnormal_embryonic_tissue | 1.89700960 |
24 | MP0004084_abnormal_cardiac_muscle | 1.86024164 |
25 | MP0003283_abnormal_digestive_organ | 1.84494838 |
26 | MP0005076_abnormal_cell_differentiation | 1.84136674 |
27 | MP0003119_abnormal_digestive_system | 1.82534623 |
28 | MP0003121_genomic_imprinting | 1.81664164 |
29 | MP0003984_embryonic_growth_retardation | 1.81624214 |
30 | MP0000537_abnormal_urethra_morphology | 1.79785189 |
31 | * MP0002080_prenatal_lethality | 1.77750876 |
32 | MP0002088_abnormal_embryonic_growth/wei | 1.77295975 |
33 | MP0004272_abnormal_basement_membrane | 1.74925200 |
34 | MP0004197_abnormal_fetal_growth/weight/ | 1.70532881 |
35 | MP0010307_abnormal_tumor_latency | 1.69709976 |
36 | MP0003122_maternal_imprinting | 1.63390815 |
37 | MP0009053_abnormal_anal_canal | 1.62472327 |
38 | MP0003890_abnormal_embryonic-extraembry | 1.59055481 |
39 | MP0008877_abnormal_DNA_methylation | 1.53542056 |
40 | MP0001293_anophthalmia | 1.51677906 |
41 | MP0003567_abnormal_fetal_cardiomyocyte | 1.48803402 |
42 | MP0008438_abnormal_cutaneous_collagen | 1.46519312 |
43 | MP0000579_abnormal_nail_morphology | 1.45392180 |
44 | MP0002086_abnormal_extraembryonic_tissu | 1.44754929 |
45 | MP0003705_abnormal_hypodermis_morpholog | 1.42866628 |
46 | MP0002938_white_spotting | 1.37524157 |
47 | MP0000750_abnormal_muscle_regeneration | 1.37021855 |
48 | MP0000762_abnormal_tongue_morphology | 1.31337688 |
49 | MP0005501_abnormal_skin_physiology | 1.31066842 |
50 | MP0009672_abnormal_birth_weight | 1.29022406 |
51 | MP0000313_abnormal_cell_death | 1.26739588 |
52 | MP0005257_abnormal_intraocular_pressure | 1.25332703 |
53 | MP0002269_muscular_atrophy | 1.18807135 |
54 | MP0004858_abnormal_nervous_system | 1.17665343 |
55 | MP0003950_abnormal_plasma_membrane | 1.17645909 |
56 | MP0003941_abnormal_skin_development | 1.17309285 |
57 | MP0003566_abnormal_cell_adhesion | 1.17164345 |
58 | MP0003937_abnormal_limbs/digits/tail_de | 1.15647288 |
59 | MP0001346_abnormal_lacrimal_gland | 1.15413306 |
60 | MP0003186_abnormal_redox_activity | 1.15078584 |
61 | MP0009697_abnormal_copulation | 1.13166555 |
62 | MP0003646_muscle_fatigue | 1.12191801 |
63 | MP0006035_abnormal_mitochondrial_morpho | 1.12161780 |
64 | MP0010234_abnormal_vibrissa_follicle | 1.11681230 |
65 | MP0002234_abnormal_pharynx_morphology | 1.09091193 |
66 | MP0008260_abnormal_autophagy | 1.05325320 |
67 | MP0003221_abnormal_cardiomyocyte_apopto | 1.04403588 |
68 | MP0001299_abnormal_eye_distance/ | 1.04332325 |
69 | MP0003718_maternal_effect | 1.04278620 |
70 | MP0005623_abnormal_meninges_morphology | 1.03277768 |
71 | MP0006292_abnormal_olfactory_placode | 1.02540027 |
72 | MP0000358_abnormal_cell_content/ | 1.01259404 |
73 | MP0001661_extended_life_span | 0.98383062 |
74 | MP0005171_absent_coat_pigmentation | 0.98011852 |
75 | MP0002089_abnormal_postnatal_growth/wei | 0.97524961 |
76 | MP0003755_abnormal_palate_morphology | 0.97104575 |
77 | MP0005266_abnormal_metabolism | 0.96650660 |
78 | MP0000751_myopathy | 0.95999804 |
79 | MP0003861_abnormal_nervous_system | 0.95950439 |
80 | MP0000428_abnormal_craniofacial_morphol | 0.95849570 |
81 | MP0002060_abnormal_skin_morphology | 0.95712546 |
82 | MP0001849_ear_inflammation | 0.95398397 |
83 | MP0002019_abnormal_tumor_incidence | 0.93164767 |
84 | MP0000490_abnormal_crypts_of | 0.93010999 |
85 | MP0002092_abnormal_eye_morphology | 0.92623352 |
86 | MP0003385_abnormal_body_wall | 0.91829668 |
87 | MP0000003_abnormal_adipose_tissue | 0.91687894 |
88 | MP0008775_abnormal_heart_ventricle | 0.90875264 |
89 | MP0002111_abnormal_tail_morphology | 0.90502754 |
90 | MP0003806_abnormal_nucleotide_metabolis | 0.89808097 |
91 | MP0006072_abnormal_retinal_apoptosis | 0.87949313 |
92 | MP0005451_abnormal_body_composition | 0.85589582 |
93 | MP0003115_abnormal_respiratory_system | 0.85379222 |
94 | MP0009379_abnormal_foot_pigmentation | 0.84919581 |
95 | MP0002233_abnormal_nose_morphology | 0.84628072 |
96 | MP0004087_abnormal_muscle_fiber | 0.84600772 |
97 | MP0002163_abnormal_gland_morphology | 0.84467726 |
98 | MP0005197_abnormal_uvea_morphology | 0.84065444 |
99 | MP0003786_premature_aging | 0.83648321 |
100 | MP0004036_abnormal_muscle_relaxation | 0.83543144 |
101 | MP0009703_decreased_birth_body | 0.83385862 |
102 | MP0010630_abnormal_cardiac_muscle | 0.83035111 |
103 | MP0005384_cellular_phenotype | 0.82721642 |
104 | MP0000733_abnormal_muscle_development | 0.82310001 |
105 | MP0002697_abnormal_eye_size | 0.79656893 |
106 | MP0000534_abnormal_ureter_morphology | 0.79125491 |
107 | MP0005394_taste/olfaction_phenotype | 0.78982473 |
108 | MP0005499_abnormal_olfactory_system | 0.78982473 |
109 | MP0004808_abnormal_hematopoietic_stem | 0.78785661 |
110 | MP0000566_synostosis | 0.77351472 |
111 | MP0002396_abnormal_hematopoietic_system | 0.77079187 |
112 | MP0000266_abnormal_heart_morphology | 0.77045568 |
113 | MP0002796_impaired_skin_barrier | 0.76637597 |
114 | MP0000749_muscle_degeneration | 0.76513585 |
115 | MP0000858_altered_metastatic_potential | 0.76468455 |
116 | MP0001286_abnormal_eye_development | 0.76259735 |
117 | MP0000747_muscle_weakness | 0.75877224 |
118 | MP0002127_abnormal_cardiovascular_syste | 0.75511862 |
119 | MP0008789_abnormal_olfactory_epithelium | 0.75211760 |
120 | MP0002925_abnormal_cardiovascular_devel | 0.74706728 |
121 | MP0000467_abnormal_esophagus_morphology | 0.74611963 |
122 | MP0004215_abnormal_myocardial_fiber | 0.72399536 |
123 | MP0001348_abnormal_lacrimal_gland | 0.72226196 |
124 | * MP0008770_decreased_survivor_rate | 0.72114016 |
125 | MP0005621_abnormal_cell_physiology | 0.71041175 |
126 | MP0003315_abnormal_perineum_morphology | 0.71040592 |
127 | MP0000759_abnormal_skeletal_muscle | 0.70381925 |
128 | MP0000049_abnormal_middle_ear | 0.68829231 |
129 | MP0002751_abnormal_autonomic_nervous | 0.68506402 |
130 | MP0005023_abnormal_wound_healing | 0.67544078 |
131 | MP0002106_abnormal_muscle_physiology | 0.66988686 |
132 | MP0001529_abnormal_vocalization | 0.66367631 |
133 | MP0003942_abnormal_urinary_system | 0.66020394 |
134 | MP0002332_abnormal_exercise_endurance | 0.62551083 |
135 | MP0001915_intracranial_hemorrhage | 0.61945566 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Ependymoma (HP:0002888) | 4.50764904 |
2 | Selective tooth agenesis (HP:0001592) | 3.66243182 |
3 | Abnormality of the labia minora (HP:0012880) | 3.62132438 |
4 | Reticulocytopenia (HP:0001896) | 3.54835952 |
5 | Abdominal situs inversus (HP:0003363) | 3.41324961 |
6 | Abnormality of abdominal situs (HP:0011620) | 3.41324961 |
7 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 3.39685480 |
8 | Colon cancer (HP:0003003) | 3.33242659 |
9 | Abnormal number of incisors (HP:0011064) | 3.33142953 |
10 | Birth length less than 3rd percentile (HP:0003561) | 3.19730157 |
11 | Medulloblastoma (HP:0002885) | 3.17871598 |
12 | Astrocytoma (HP:0009592) | 3.15879906 |
13 | Abnormality of the astrocytes (HP:0100707) | 3.15879906 |
14 | Agnosia (HP:0010524) | 3.09268786 |
15 | Exercise-induced muscle cramps (HP:0003710) | 3.00819254 |
16 | Adenoma sebaceum (HP:0009720) | 2.99288621 |
17 | Angiofibromas (HP:0010615) | 2.99288621 |
18 | Oral leukoplakia (HP:0002745) | 2.98715747 |
19 | Microvesicular hepatic steatosis (HP:0001414) | 2.92242160 |
20 | Abnormality of the anterior horn cell (HP:0006802) | 2.81117064 |
21 | Degeneration of anterior horn cells (HP:0002398) | 2.81117064 |
22 | Hypoplasia of the capital femoral epiphysis (HP:0003090) | 2.75646892 |
23 | Cortical dysplasia (HP:0002539) | 2.70836291 |
24 | Congenital stationary night blindness (HP:0007642) | 2.66686135 |
25 | Premature rupture of membranes (HP:0001788) | 2.63984119 |
26 | Breast hypoplasia (HP:0003187) | 2.63129160 |
27 | Trismus (HP:0000211) | 2.62113301 |
28 | Abnormal gallbladder physiology (HP:0012438) | 2.54209565 |
29 | Cholecystitis (HP:0001082) | 2.54209565 |
30 | Insomnia (HP:0100785) | 2.52416984 |
31 | Deviation of the thumb (HP:0009603) | 2.49314768 |
32 | Increased serum pyruvate (HP:0003542) | 2.48308722 |
33 | Abnormality of glycolysis (HP:0004366) | 2.48308722 |
34 | Rhabdomyosarcoma (HP:0002859) | 2.48159624 |
35 | Proximal placement of thumb (HP:0009623) | 2.46206984 |
36 | Glioma (HP:0009733) | 2.41362712 |
37 | Absent radius (HP:0003974) | 2.39993028 |
38 | Absent epiphyses (HP:0010577) | 2.39096389 |
39 | Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003) | 2.39096389 |
40 | Absent thumb (HP:0009777) | 2.36505897 |
41 | Increased nuchal translucency (HP:0010880) | 2.36189669 |
42 | Patellar aplasia (HP:0006443) | 2.34354266 |
43 | Long palpebral fissure (HP:0000637) | 2.33718752 |
44 | Cerebral hypomyelination (HP:0006808) | 2.32959235 |
45 | Septo-optic dysplasia (HP:0100842) | 2.32369785 |
46 | Pterygium (HP:0001059) | 2.30884299 |
47 | Carpal bone hypoplasia (HP:0001498) | 2.27860621 |
48 | Upper limb muscle weakness (HP:0003484) | 2.27841511 |
49 | Neoplasm of striated muscle (HP:0009728) | 2.27764054 |
50 | Abnormality of the umbilical cord (HP:0010881) | 2.27166917 |
51 | Spastic diplegia (HP:0001264) | 2.26272500 |
52 | Absent forearm bone (HP:0003953) | 2.25796953 |
53 | Aplasia involving forearm bones (HP:0009822) | 2.25796953 |
54 | Rhabdomyolysis (HP:0003201) | 2.25098813 |
55 | Missing ribs (HP:0000921) | 2.22992339 |
56 | Atresia of the external auditory canal (HP:0000413) | 2.22587393 |
57 | Supernumerary spleens (HP:0009799) | 2.21842362 |
58 | Neoplasm of the pancreas (HP:0002894) | 2.20759052 |
59 | Basal cell carcinoma (HP:0002671) | 2.17198274 |
60 | Abnormality of reticulocytes (HP:0004312) | 2.16930079 |
61 | Abnormality of cells of the erythroid lineage (HP:0012130) | 2.16239664 |
62 | Tracheoesophageal fistula (HP:0002575) | 2.16048711 |
63 | Entropion (HP:0000621) | 2.14890573 |
64 | Overriding aorta (HP:0002623) | 2.14735111 |
65 | Aplasia/Hypoplasia of the patella (HP:0006498) | 2.14571903 |
66 | Postnatal microcephaly (HP:0005484) | 2.12363137 |
67 | Microglossia (HP:0000171) | 2.12023796 |
68 | Pointed chin (HP:0000307) | 2.11115395 |
69 | Aplasia/hypoplasia of the humerus (HP:0006507) | 2.10447282 |
70 | Renal duplication (HP:0000075) | 2.09157424 |
71 | Neoplasm of the oral cavity (HP:0100649) | 2.09014711 |
72 | Horseshoe kidney (HP:0000085) | 2.08416366 |
73 | Abnormality of the preputium (HP:0100587) | 2.07294343 |
74 | Myoglobinuria (HP:0002913) | 2.06995614 |
75 | Squamous cell carcinoma (HP:0002860) | 2.05702107 |
76 | Progressive muscle weakness (HP:0003323) | 2.04029895 |
77 | Shoulder girdle muscle weakness (HP:0003547) | 2.04018858 |
78 | Hyperacusis (HP:0010780) | 2.02825998 |
79 | Cholelithiasis (HP:0001081) | 2.02684255 |
80 | Macrocytic anemia (HP:0001972) | 2.00887563 |
81 | Rough bone trabeculation (HP:0100670) | 2.00374424 |
82 | Preauricular skin tag (HP:0000384) | 2.00096832 |
83 | Pelvic girdle muscle weakness (HP:0003749) | 1.97869108 |
84 | Prominent metopic ridge (HP:0005487) | 1.95510057 |
85 | Emotional lability (HP:0000712) | 1.94973394 |
86 | Skin tags (HP:0010609) | 1.92175271 |
87 | Severe visual impairment (HP:0001141) | 1.90941449 |
88 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 1.89607303 |
89 | Aplasia/Hypoplasia of the sternum (HP:0006714) | 1.88246622 |
90 | Abnormalities of placenta or umbilical cord (HP:0001194) | 1.87505344 |
91 | Poikiloderma (HP:0001029) | 1.86900016 |
92 | Broad distal phalanx of finger (HP:0009836) | 1.86319008 |
93 | Maternal diabetes (HP:0009800) | 1.85611913 |
94 | Multiple enchondromatosis (HP:0005701) | 1.85141284 |
95 | Abnormal lung lobation (HP:0002101) | 1.85133275 |
96 | Atrophy/Degeneration involving motor neurons (HP:0007373) | 1.84687836 |
97 | High anterior hairline (HP:0009890) | 1.84510059 |
98 | Meckel diverticulum (HP:0002245) | 1.83938835 |
99 | Hypoplastic pelvis (HP:0008839) | 1.83265193 |
100 | Abnormality of the lower motor neuron (HP:0002366) | 1.81976606 |
101 | Short nail (HP:0001799) | 1.81597477 |
102 | Aplasia/Hypoplasia of the spleen (HP:0010451) | 1.80986643 |
103 | Aplastic anemia (HP:0001915) | 1.80564590 |
104 | Elfin facies (HP:0004428) | 1.79826802 |
105 | Ovarian neoplasm (HP:0100615) | 1.79460107 |
106 | Limb-girdle muscle atrophy (HP:0003797) | 1.79130492 |
107 | Breast aplasia (HP:0100783) | 1.79007503 |
108 | Short humerus (HP:0005792) | 1.78763072 |
109 | Neuroblastoma (HP:0003006) | 1.78327688 |
110 | Primitive neuroectodermal tumor (HP:0030065) | 1.78327688 |
111 | Neuroblastic tumors (HP:0004376) | 1.78327688 |
112 | Peripheral primitive neuroectodermal neoplasm (HP:0030067) | 1.78327688 |
113 | Asplenia (HP:0001746) | 1.78270969 |
114 | Unsteady gait (HP:0002317) | 1.77594112 |
115 | Freckling (HP:0001480) | 1.76385447 |
116 | Trigonocephaly (HP:0000243) | 1.76234184 |
117 | Chromsome breakage (HP:0040012) | 1.75861442 |
118 | Abnormal number of erythroid precursors (HP:0012131) | 1.75615270 |
119 | Biliary tract neoplasm (HP:0100574) | 1.75393345 |
120 | Abnormal gallbladder morphology (HP:0012437) | 1.75363400 |
121 | Pallor (HP:0000980) | 1.75314406 |
122 | Cleft eyelid (HP:0000625) | 1.75219735 |
123 | Abnormality of the ileum (HP:0001549) | 1.75139736 |
124 | Esophageal atresia (HP:0002032) | 1.74836569 |
125 | Anophthalmia (HP:0000528) | 1.74057805 |
126 | Intestinal polyp (HP:0005266) | 1.73649090 |
127 | Abnormality of the calcaneus (HP:0008364) | 1.73346415 |
128 | Small intestinal stenosis (HP:0012848) | 1.73331853 |
129 | Duodenal stenosis (HP:0100867) | 1.73331853 |
130 | Glossoptosis (HP:0000162) | 1.72588426 |
131 | Facial cleft (HP:0002006) | 1.72249232 |
132 | Cellular immunodeficiency (HP:0005374) | 1.70955927 |
133 | Pseudobulbar signs (HP:0002200) | 1.70955214 |
134 | Adducted thumb (HP:0001181) | 1.70861405 |
135 | Abnormality of the metopic suture (HP:0005556) | 1.70600369 |
136 | Generalized hypotonia (HP:0001290) | 1.70200113 |
137 | Slender long bone (HP:0003100) | 1.69487830 |
138 | Vertebral compression fractures (HP:0002953) | 1.68330198 |
139 | Secondary amenorrhea (HP:0000869) | 1.67945629 |
140 | Abnormality of the carotid arteries (HP:0005344) | 1.67776223 |
141 | Fibroma (HP:0010614) | 1.67004962 |
142 | Exercise intolerance (HP:0003546) | 1.66196700 |
143 | Calcaneovalgus deformity (HP:0001848) | 1.66161004 |
144 | Distal upper limb amyotrophy (HP:0007149) | 1.66085293 |
145 | Upper limb amyotrophy (HP:0009129) | 1.66085293 |
146 | Breech presentation (HP:0001623) | 1.65654670 |
147 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 1.63454429 |
148 | Ulnar bowing (HP:0003031) | 1.62397496 |
149 | Small epiphyses (HP:0010585) | 1.62133386 |
150 | Progressive external ophthalmoplegia (HP:0000590) | 1.61091981 |
151 | Hand muscle atrophy (HP:0009130) | 1.61083724 |
152 | Achilles tendon contracture (HP:0001771) | 1.60666102 |
153 | Aplasia/Hypoplasia of the breasts (HP:0010311) | 1.56429341 |
154 | Distal lower limb amyotrophy (HP:0008944) | 1.55033839 |
155 | Abnormality of the gallbladder (HP:0005264) | 1.54696583 |
156 | Nephroblastoma (Wilms tumor) (HP:0002667) | 1.52010779 |
157 | Natal tooth (HP:0000695) | 1.51134400 |
158 | Deformed tarsal bones (HP:0008119) | 1.50544197 |
159 | Overlapping toe (HP:0001845) | 1.46317835 |
160 | Abnormal mitochondria in muscle tissue (HP:0008316) | 1.44009639 |
161 | Abnormality of chromosome stability (HP:0003220) | 1.43804291 |
162 | Flattened epiphyses (HP:0003071) | 1.43201705 |
Rank | Gene Set | Z-score |
---|---|---|
1 | NEK1 | 4.75677743 |
2 | CDC7 | 3.99300492 |
3 | BUB1 | 3.54027013 |
4 | VRK2 | 3.41762978 |
5 | WEE1 | 3.34284697 |
6 | TSSK6 | 3.23477998 |
7 | PKN2 | 2.97429801 |
8 | TESK2 | 2.90900788 |
9 | SMG1 | 2.62261180 |
10 | NEK2 | 2.49507683 |
11 | EIF2AK1 | 2.47504320 |
12 | EEF2K | 2.36923082 |
13 | CDK12 | 2.34050696 |
14 | RPS6KB2 | 2.04417473 |
15 | TRIM28 | 1.90959728 |
16 | PASK | 1.86812083 |
17 | PAK4 | 1.79256869 |
18 | TESK1 | 1.78670338 |
19 | TTK | 1.68621252 |
20 | CDK7 | 1.61680276 |
21 | ALK | 1.60405411 |
22 | SCYL2 | 1.54758891 |
23 | PLK1 | 1.48626793 |
24 | MAP3K8 | 1.46702452 |
25 | IRAK3 | 1.43666900 |
26 | FLT3 | 1.41406243 |
27 | TLK1 | 1.40671173 |
28 | PLK3 | 1.37425858 |
29 | ATR | 1.35395009 |
30 | ERBB4 | 1.31759697 |
31 | TAF1 | 1.31194820 |
32 | MST1R | 1.31052275 |
33 | EPHA2 | 1.28237436 |
34 | ICK | 1.26358656 |
35 | AURKB | 1.21348965 |
36 | TRIB3 | 1.21016399 |
37 | BRD4 | 1.20922756 |
38 | ARAF | 1.20799512 |
39 | SIK3 | 1.20084243 |
40 | TGFBR1 | 1.15467819 |
41 | NME2 | 1.15381853 |
42 | BCKDK | 1.14718878 |
43 | STK16 | 1.14503296 |
44 | CHEK1 | 1.10907481 |
45 | LMTK2 | 1.09800696 |
46 | CDK4 | 1.09685857 |
47 | LIMK1 | 1.08565050 |
48 | LATS2 | 1.06339613 |
49 | SRPK1 | 1.04934063 |
50 | MAP3K10 | 1.04106355 |
51 | AURKA | 1.03282120 |
52 | MET | 1.02866785 |
53 | TTN | 1.01773593 |
54 | PTK2 | 1.01608778 |
55 | LRRK2 | 1.00306552 |
56 | FGFR1 | 0.99678844 |
57 | MKNK1 | 0.96869689 |
58 | BRSK1 | 0.96081575 |
59 | CDK19 | 0.95540263 |
60 | DAPK1 | 0.90999468 |
61 | NME1 | 0.90892448 |
62 | DAPK3 | 0.90653698 |
63 | NTRK1 | 0.86355721 |
64 | PDK2 | 0.83016775 |
65 | MAP3K11 | 0.82883781 |
66 | CDK2 | 0.81644502 |
67 | PAK1 | 0.81405874 |
68 | ILK | 0.79634682 |
69 | KSR1 | 0.78286915 |
70 | KSR2 | 0.78084787 |
71 | MAP3K9 | 0.77678064 |
72 | BMX | 0.76449434 |
73 | TAOK2 | 0.76206556 |
74 | BRSK2 | 0.75696112 |
75 | MINK1 | 0.75360988 |
76 | MOS | 0.75350317 |
77 | PLK4 | 0.73992239 |
78 | BCR | 0.73507737 |
79 | CHEK2 | 0.73007258 |
80 | CDK14 | 0.71763073 |
81 | RPS6KA4 | 0.71006142 |
82 | STK10 | 0.68999482 |
83 | CDK11A | 0.67130983 |
84 | CDK18 | 0.66704193 |
85 | CDK15 | 0.66375826 |
86 | VRK1 | 0.65934550 |
87 | CCNB1 | 0.65279381 |
88 | PDGFRA | 0.64502368 |
89 | PNCK | 0.63069936 |
90 | ATM | 0.61920580 |
91 | CSNK1E | 0.58942393 |
92 | MTOR | 0.57583094 |
93 | BRAF | 0.57050812 |
94 | CSNK2A2 | 0.56922648 |
95 | CDK6 | 0.56235215 |
96 | CDK8 | 0.56207315 |
97 | MAP2K3 | 0.55883765 |
98 | EIF2AK2 | 0.55830330 |
99 | EIF2AK3 | 0.54679054 |
100 | PAK6 | 0.54544388 |
101 | EPHB2 | 0.54415958 |
102 | CDK1 | 0.54072374 |
103 | MAPKAPK3 | 0.53301533 |
104 | CSNK1G3 | 0.52096560 |
105 | ACVR1B | 0.51107775 |
106 | KDR | 0.50520470 |
107 | SIK1 | 0.47663082 |
108 | DYRK3 | 0.46301169 |
109 | STK4 | 0.45993694 |
110 | CSNK2A1 | 0.44025481 |
111 | UHMK1 | 0.43404203 |
112 | PRKCI | 0.42768540 |
113 | CDK9 | 0.42654178 |
114 | RIPK1 | 0.40601565 |
115 | ZAK | 0.39639606 |
116 | PDK4 | 0.39384396 |
117 | PDK3 | 0.39384396 |
118 | DYRK2 | 0.39335082 |
119 | * AKT2 | 0.39097007 |
120 | PRKDC | 0.39032809 |
121 | PBK | 0.38254835 |
122 | PRKD3 | 0.35783585 |
123 | MKNK2 | 0.33074915 |
124 | STK38L | 0.31484458 |
125 | ROCK2 | 0.30917608 |
126 | PAK2 | 0.30713126 |
127 | PIM2 | 0.30536344 |
Rank | Gene Set | Z-score |
---|---|---|
1 | DNA replication_Homo sapiens_hsa03030 | 4.72129695 |
2 | Mismatch repair_Homo sapiens_hsa03430 | 3.90368966 |
3 | Spliceosome_Homo sapiens_hsa03040 | 3.24105247 |
4 | Ribosome_Homo sapiens_hsa03010 | 3.22816861 |
5 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.94153565 |
6 | RNA transport_Homo sapiens_hsa03013 | 2.92366047 |
7 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.91222042 |
8 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.78562292 |
9 | Base excision repair_Homo sapiens_hsa03410 | 2.56811160 |
10 | Proteasome_Homo sapiens_hsa03050 | 2.38920943 |
11 | Cell cycle_Homo sapiens_hsa04110 | 2.35349710 |
12 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.26904813 |
13 | * Biosynthesis of amino acids_Homo sapiens_hsa01230 | 2.23317177 |
14 | Homologous recombination_Homo sapiens_hsa03440 | 2.15686006 |
15 | RNA polymerase_Homo sapiens_hsa03020 | 2.13481786 |
16 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 2.12304747 |
17 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 2.01935490 |
18 | * Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 1.84843266 |
19 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.79788360 |
20 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 1.72313719 |
21 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.71275562 |
22 | * Carbon metabolism_Homo sapiens_hsa01200 | 1.60610691 |
23 | RNA degradation_Homo sapiens_hsa03018 | 1.56626176 |
24 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 1.56552002 |
25 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 1.43562351 |
26 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 1.32590815 |
27 | Oocyte meiosis_Homo sapiens_hsa04114 | 1.29702822 |
28 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 1.29009565 |
29 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.28817139 |
30 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.27496402 |
31 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 1.27094186 |
32 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.25899857 |
33 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.21757750 |
34 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.21389864 |
35 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.20520492 |
36 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 1.13637103 |
37 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.12785127 |
38 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.08853376 |
39 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 1.08574802 |
40 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 1.00414104 |
41 | Basal cell carcinoma_Homo sapiens_hsa05217 | 1.00210365 |
42 | Parkinsons disease_Homo sapiens_hsa05012 | 0.99156882 |
43 | * HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.98779798 |
44 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.97936540 |
45 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.97258612 |
46 | Purine metabolism_Homo sapiens_hsa00230 | 0.96512224 |
47 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.96508453 |
48 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.95543386 |
49 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.93679446 |
50 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.93164434 |
51 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.90778301 |
52 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.90571250 |
53 | Bladder cancer_Homo sapiens_hsa05219 | 0.89979950 |
54 | Galactose metabolism_Homo sapiens_hsa00052 | 0.88397127 |
55 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.88321965 |
56 | Thyroid cancer_Homo sapiens_hsa05216 | 0.86653031 |
57 | Protein export_Homo sapiens_hsa03060 | 0.86408044 |
58 | Huntingtons disease_Homo sapiens_hsa05016 | 0.86157132 |
59 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.79015757 |
60 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.76886993 |
61 | HTLV-I infection_Homo sapiens_hsa05166 | 0.76626976 |
62 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.73214091 |
63 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.72766608 |
64 | Basal transcription factors_Homo sapiens_hsa03022 | 0.72006663 |
65 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.71562169 |
66 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.69112142 |
67 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.68464077 |
68 | Lysine degradation_Homo sapiens_hsa00310 | 0.67404283 |
69 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.64538008 |
70 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.60631116 |
71 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.57819336 |
72 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.53489076 |
73 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.52276778 |
74 | Tight junction_Homo sapiens_hsa04530 | 0.48762634 |
75 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.48727651 |
76 | Colorectal cancer_Homo sapiens_hsa05210 | 0.48278913 |
77 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.46977372 |
78 | Alcoholism_Homo sapiens_hsa05034 | 0.46302831 |
79 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.45881682 |
80 | Melanoma_Homo sapiens_hsa05218 | 0.45673625 |
81 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.45556687 |
82 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.44222379 |
83 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.44094181 |
84 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.43375465 |
85 | * Metabolic pathways_Homo sapiens_hsa01100 | 0.42423813 |
86 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.41368106 |
87 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.41303678 |
88 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.40794543 |
89 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.40775240 |
90 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.40232353 |
91 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 0.39987666 |
92 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.38704278 |
93 | Gap junction_Homo sapiens_hsa04540 | 0.38395886 |
94 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.38114153 |
95 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.37305390 |
96 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.37298262 |
97 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.37151781 |
98 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.36996664 |
99 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.36802293 |
100 | Adherens junction_Homo sapiens_hsa04520 | 0.36665105 |
101 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.36179737 |
102 | Glioma_Homo sapiens_hsa05214 | 0.35517420 |
103 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 0.35444626 |
104 | Melanogenesis_Homo sapiens_hsa04916 | 0.35382226 |
105 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.34236533 |
106 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.33213210 |
107 | Legionellosis_Homo sapiens_hsa05134 | 0.33124278 |
108 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.32152816 |
109 | Pathways in cancer_Homo sapiens_hsa05200 | 0.31475653 |
110 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.30480135 |
111 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.29249763 |
112 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.28856601 |
113 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.28417943 |
114 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.28032540 |
115 | Phototransduction_Homo sapiens_hsa04744 | 0.26781012 |
116 | Sulfur relay system_Homo sapiens_hsa04122 | 0.25836744 |
117 | Shigellosis_Homo sapiens_hsa05131 | 0.25003761 |
118 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.24078034 |
119 | Long-term potentiation_Homo sapiens_hsa04720 | 0.24062667 |
120 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.23591524 |
121 | Prostate cancer_Homo sapiens_hsa05215 | 0.23051218 |
122 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.22791491 |
123 | Alzheimers disease_Homo sapiens_hsa05010 | 0.21968215 |
124 | Endometrial cancer_Homo sapiens_hsa05213 | 0.20548514 |
125 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.20065281 |
126 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.18761779 |
127 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.18734244 |
128 | Viral myocarditis_Homo sapiens_hsa05416 | 0.17867869 |