GAPDHP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)7.05089043
2eosinophil chemotaxis (GO:0048245)6.13488922
3DNA deamination (GO:0045006)6.12908069
4cytidine deamination (GO:0009972)5.66358343
5cytidine metabolic process (GO:0046087)5.66358343
6cytidine catabolic process (GO:0006216)5.66358343
7eosinophil migration (GO:0072677)5.54428401
8protein prenylation (GO:0018342)5.49682306
9prenylation (GO:0097354)5.49682306
10negative regulation of T cell receptor signaling pathway (GO:0050860)5.38151933
11mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.30971165
12proteasome assembly (GO:0043248)5.19813193
13energy coupled proton transport, down electrochemical gradient (GO:0015985)5.02101677
14ATP synthesis coupled proton transport (GO:0015986)5.02101677
15L-fucose catabolic process (GO:0042355)4.97873686
16fucose catabolic process (GO:0019317)4.97873686
17L-fucose metabolic process (GO:0042354)4.97873686
18regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.93020166
19pyrimidine ribonucleoside catabolic process (GO:0046133)4.80040934
20establishment of protein localization to mitochondrial membrane (GO:0090151)4.49612030
21negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)4.48535810
22protein neddylation (GO:0045116)4.40627388
23negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.20876902
24regulation of cellular amino acid metabolic process (GO:0006521)4.20557854
25mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.10436060
26chaperone-mediated protein transport (GO:0072321)4.05188709
27DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.01976199
28signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.93483748
29signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.93483748
30signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.93483748
31intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.89966593
32signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.89966593
33regulation of mononuclear cell migration (GO:0071675)3.88009271
34DNA demethylation (GO:0080111)3.84818430
35respiratory electron transport chain (GO:0022904)3.84681561
36regulation of T cell receptor signaling pathway (GO:0050856)3.81653111
37electron transport chain (GO:0022900)3.79609269
38positive regulation of mitotic sister chromatid separation (GO:1901970)3.79049738
39positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.79049738
40positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.79049738
41negative regulation of Ras GTPase activity (GO:0034261)3.78236545
42positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.77933623
43transcription elongation from RNA polymerase III promoter (GO:0006385)3.76116736
44termination of RNA polymerase III transcription (GO:0006386)3.76116736
45signal transduction involved in DNA damage checkpoint (GO:0072422)3.75459284
46signal transduction involved in DNA integrity checkpoint (GO:0072401)3.75459284
47negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.72280080
48negative regulation of ligase activity (GO:0051352)3.72280080
49signal transduction involved in cell cycle checkpoint (GO:0072395)3.72075802
50regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.66818080
51negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.49090888
52macrophage chemotaxis (GO:0048246)3.47749260
53protein complex biogenesis (GO:0070271)3.47525473
54water-soluble vitamin biosynthetic process (GO:0042364)3.37239384
55RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.36919114
56tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.36919114
57anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.36842203
58metallo-sulfur cluster assembly (GO:0031163)3.27324346
59iron-sulfur cluster assembly (GO:0016226)3.27324346
60nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.23716667
61intracellular protein transmembrane import (GO:0044743)3.22805185
62mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.22060295
63mitochondrial respiratory chain complex I assembly (GO:0032981)3.22060295
64NADH dehydrogenase complex assembly (GO:0010257)3.22060295
65DNA dealkylation (GO:0035510)3.20475916
66sequestering of actin monomers (GO:0042989)3.20139572
67positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.19363786
68respiratory chain complex IV assembly (GO:0008535)3.18721698
69antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.17079154
70mitochondrial respiratory chain complex assembly (GO:0033108)3.13547680
71exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.10684064
72regulation of sister chromatid cohesion (GO:0007063)3.04558558
73positive regulation of ligase activity (GO:0051351)3.03587120
74double-strand break repair via nonhomologous end joining (GO:0006303)3.00007691
75non-recombinational repair (GO:0000726)3.00007691
76positive regulation of cell cycle arrest (GO:0071158)2.99659299
77autophagic vacuole fusion (GO:0000046)2.98683428
78regulation of cellular amine metabolic process (GO:0033238)2.97623116
79preassembly of GPI anchor in ER membrane (GO:0016254)2.97514775
80inner mitochondrial membrane organization (GO:0007007)2.96664353
81hydrogen ion transmembrane transport (GO:1902600)2.92609701
82DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.91286085
83GPI anchor biosynthetic process (GO:0006506)2.89404994
84antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.88922921
85ATP biosynthetic process (GO:0006754)2.85818621
86GPI anchor metabolic process (GO:0006505)2.82744197
87branch elongation of an epithelium (GO:0060602)2.82514371
88cullin deneddylation (GO:0010388)2.80643145
89platelet dense granule organization (GO:0060155)2.79466956
90monocyte chemotaxis (GO:0002548)2.78026328
91cytochrome complex assembly (GO:0017004)2.77927984
92protein deneddylation (GO:0000338)2.75362123
93proton transport (GO:0015992)2.74570171
94negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.72816131
95coenzyme A biosynthetic process (GO:0015937)2.72580158
96translation (GO:0006412)2.72496730
97regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.72301524
98purine nucleoside triphosphate biosynthetic process (GO:0009145)2.71050037
99purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.69493262
100regulation of mitochondrial translation (GO:0070129)2.68988858

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse6.62280595
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.05398487
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.64127939
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.61627495
5VDR_22108803_ChIP-Seq_LS180_Human3.59844115
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.30799590
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.16228145
8GATA1_22025678_ChIP-Seq_K562_Human2.83606214
9CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.79285313
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.77356174
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.69362035
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.66773286
13VDR_23849224_ChIP-Seq_CD4+_Human2.56919996
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.49141892
15BP1_19119308_ChIP-ChIP_Hs578T_Human2.41255133
16SRF_21415370_ChIP-Seq_HL-1_Mouse2.37751240
17ELK1_19687146_ChIP-ChIP_HELA_Human2.37115868
18ZNF274_21170338_ChIP-Seq_K562_Hela2.36324109
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.29678234
20CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.29131406
21NOTCH1_21737748_ChIP-Seq_TLL_Human2.27249631
22MYC_18555785_ChIP-Seq_MESCs_Mouse2.22975180
23FOXP3_21729870_ChIP-Seq_TREG_Human2.19274682
24FLI1_27457419_Chip-Seq_LIVER_Mouse2.16602490
25YY1_21170310_ChIP-Seq_MESCs_Mouse1.89797569
26MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.84792868
27E2F4_17652178_ChIP-ChIP_JURKAT_Human1.81069591
28FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.78219435
29CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.78073867
30PCGF2_27294783_Chip-Seq_ESCs_Mouse1.72292601
31MYC_18358816_ChIP-ChIP_MESCs_Mouse1.71780024
32IRF1_19129219_ChIP-ChIP_H3396_Human1.52607761
33RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51112261
34HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.46321515
35MYC_18940864_ChIP-ChIP_HL60_Human1.44686207
36PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.43635726
37MYC_19030024_ChIP-ChIP_MESCs_Mouse1.41343485
38IGF1R_20145208_ChIP-Seq_DFB_Human1.40844783
39GABP_19822575_ChIP-Seq_HepG2_Human1.37898009
40POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.37246730
41PCGF2_27294783_Chip-Seq_NPCs_Mouse1.34368020
42E2F1_18555785_ChIP-Seq_MESCs_Mouse1.33982153
43PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.31740163
44DCP1A_22483619_ChIP-Seq_HELA_Human1.28292601
45TTF2_22483619_ChIP-Seq_HELA_Human1.27725104
46ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.26758933
47GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26628113
48IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.25967661
49EZH2_22144423_ChIP-Seq_EOC_Human1.25527819
50TP53_22573176_ChIP-Seq_HFKS_Human1.24617979
51HOXB4_20404135_ChIP-ChIP_EML_Mouse1.23544346
52FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.23428851
53ELK1_22589737_ChIP-Seq_MCF10A_Human1.22776743
54FOXA1_25329375_ChIP-Seq_VCAP_Human1.21565580
55FOXA1_27270436_Chip-Seq_PROSTATE_Human1.21565580
56EWS_26573619_Chip-Seq_HEK293_Human1.21199115
57FUS_26573619_Chip-Seq_HEK293_Human1.21003679
58THAP11_20581084_ChIP-Seq_MESCs_Mouse1.17541458
59POU5F1_16153702_ChIP-ChIP_HESCs_Human1.13709534
60SRY_22984422_ChIP-ChIP_TESTIS_Rat1.13211268
61TAF15_26573619_Chip-Seq_HEK293_Human1.12604414
62ERG_20517297_ChIP-Seq_VCAP_Human1.10618990
63AR_20517297_ChIP-Seq_VCAP_Human1.09304955
64EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.08958557
65FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.08925684
66HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.07629121
67NANOG_19829295_ChIP-Seq_ESCs_Human1.07558605
68SOX2_19829295_ChIP-Seq_ESCs_Human1.07558605
69PADI4_21655091_ChIP-ChIP_MCF-7_Human1.03209426
70HTT_18923047_ChIP-ChIP_STHdh_Human1.02778146
71FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.02361210
72SUZ12_27294783_Chip-Seq_NPCs_Mouse0.99327877
73NFE2_27457419_Chip-Seq_LIVER_Mouse0.99022794
74CTBP1_25329375_ChIP-Seq_LNCAP_Human0.98835685
75EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.96566922
76AUTS2_25519132_ChIP-Seq_293T-REX_Human0.95325540
77XRN2_22483619_ChIP-Seq_HELA_Human0.95155893
78P300_19829295_ChIP-Seq_ESCs_Human0.93882677
79NANOG_20526341_ChIP-Seq_ESCs_Human0.93149153
80HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.92430106
81ZFP57_27257070_Chip-Seq_ESCs_Mouse0.92319936
82NANOG_16153702_ChIP-ChIP_HESCs_Human0.90877377
83NCOR_22424771_ChIP-Seq_293T_Human0.89981133
84EGR1_23403033_ChIP-Seq_LIVER_Mouse0.89882269
85IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.88774833
86MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.88641156
87BCAT_22108803_ChIP-Seq_LS180_Human0.87655519
88CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.87617477
89CTBP2_25329375_ChIP-Seq_LNCAP_Human0.86759321
90GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.86410687
91CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.86295126
92NELFA_20434984_ChIP-Seq_ESCs_Mouse0.85965784
93TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84556296
94PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.82838297
95GATA3_26560356_Chip-Seq_TH1_Human0.79865402
96MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.79659531
97CBP_20019798_ChIP-Seq_JUKART_Human0.79578966
98IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.79578966
99MYC_19079543_ChIP-ChIP_MESCs_Mouse0.79255029
100EZH2_27294783_Chip-Seq_NPCs_Mouse0.78069049

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis7.01828219
2MP0006082_CNS_inflammation3.41624510
3MP0003646_muscle_fatigue3.10133197
4MP0002102_abnormal_ear_morphology2.90186290
5MP0005671_abnormal_response_to2.62249557
6MP0005645_abnormal_hypothalamus_physiol2.41440605
7MP0001919_abnormal_reproductive_system2.37359041
8MP0002234_abnormal_pharynx_morphology2.36716205
9MP0008058_abnormal_DNA_repair2.29544180
10MP0000372_irregular_coat_pigmentation2.25092842
11MP0002163_abnormal_gland_morphology2.13037437
12MP0009379_abnormal_foot_pigmentation2.02948274
13MP0008872_abnormal_physiological_respon1.86102396
14MP0006292_abnormal_olfactory_placode1.81679926
15MP0006072_abnormal_retinal_apoptosis1.76073877
16MP0001664_abnormal_digestion1.72279806
17MP0002751_abnormal_autonomic_nervous1.72000123
18MP0003303_peritoneal_inflammation1.67139605
19MP0004145_abnormal_muscle_electrophysio1.66762774
20MP0001663_abnormal_digestive_system1.64222363
21MP0005389_reproductive_system_phenotype1.62518792
22MP0008877_abnormal_DNA_methylation1.62423292
23MP0003878_abnormal_ear_physiology1.60028151
24MP0005377_hearing/vestibular/ear_phenot1.60028151
25MP0002876_abnormal_thyroid_physiology1.58739258
26MP0001293_anophthalmia1.53674888
27MP0002277_abnormal_respiratory_mucosa1.53155350
28MP0002837_dystrophic_cardiac_calcinosis1.50746626
29MP0005084_abnormal_gallbladder_morpholo1.49714510
30MP0003718_maternal_effect1.47742119
31MP0000467_abnormal_esophagus_morphology1.41123434
32MP0001764_abnormal_homeostasis1.39443398
33MP0003011_delayed_dark_adaptation1.37442881
34MP0008789_abnormal_olfactory_epithelium1.35470209
35MP0003806_abnormal_nucleotide_metabolis1.30112153
36MP0003195_calcinosis1.29927456
37MP0005379_endocrine/exocrine_gland_phen1.29447331
38MP0003786_premature_aging1.29152676
39MP0009785_altered_susceptibility_to1.27660670
40MP0005253_abnormal_eye_physiology1.26020675
41MP0002006_tumorigenesis1.25384183
42MP0002938_white_spotting1.24568475
43MP0001873_stomach_inflammation1.24155453
44MP0001529_abnormal_vocalization1.23491259
45MP0003763_abnormal_thymus_physiology1.17461980
46MP0004142_abnormal_muscle_tone1.16958122
47MP0003937_abnormal_limbs/digits/tail_de1.15561640
48MP0009333_abnormal_splenocyte_physiolog1.14146481
49MP0005075_abnormal_melanosome_morpholog1.12651427
50MP0008875_abnormal_xenobiotic_pharmacok1.11409123
51MP0004147_increased_porphyrin_level1.10637731
52MP0000490_abnormal_crypts_of1.08482036
53MP0001485_abnormal_pinna_reflex1.06355327
54MP0009697_abnormal_copulation1.04644911
55MP0005381_digestive/alimentary_phenotyp1.04284408
56MP0002166_altered_tumor_susceptibility1.03238148
57MP0006276_abnormal_autonomic_nervous1.01821981
58MP0002736_abnormal_nociception_after1.01311536
59MP0001835_abnormal_antigen_presentation0.99664623
60MP0001905_abnormal_dopamine_level0.97603992
61MP0004885_abnormal_endolymph0.97004003
62MP0005332_abnormal_amino_acid0.96519518
63MP0006036_abnormal_mitochondrial_physio0.95864025
64MP0000026_abnormal_inner_ear0.94897605
65MP0003693_abnormal_embryo_hatching0.93117774
66MP0002148_abnormal_hypersensitivity_rea0.88576643
67MP0003186_abnormal_redox_activity0.87232791
68MP0002210_abnormal_sex_determination0.86226384
69MP0008995_early_reproductive_senescence0.85171674
70MP0005551_abnormal_eye_electrophysiolog0.84916279
71MP0009764_decreased_sensitivity_to0.82309111
72MP0005499_abnormal_olfactory_system0.82105418
73MP0005394_taste/olfaction_phenotype0.82105418
74MP0002138_abnormal_hepatobiliary_system0.81739230
75MP0001800_abnormal_humoral_immune0.81543280
76MP0005166_decreased_susceptibility_to0.81291120
77MP0000383_abnormal_hair_follicle0.81264166
78MP0003283_abnormal_digestive_organ0.78519685
79MP0001984_abnormal_olfaction0.78075675
80MP0001963_abnormal_hearing_physiology0.77291234
81MP0004043_abnormal_pH_regulation0.77062782
82MP0002019_abnormal_tumor_incidence0.75763969
83MP0005167_abnormal_blood-brain_barrier0.75511197
84MP0003567_abnormal_fetal_cardiomyocyte0.72938810
85MP0005410_abnormal_fertilization0.71742722
86MP0001286_abnormal_eye_development0.71335134
87MP0005000_abnormal_immune_tolerance0.70839453
88MP0003122_maternal_imprinting0.70591800
89MP0002272_abnormal_nervous_system0.69436865
90MP0002109_abnormal_limb_morphology0.69309301
91MP0003136_yellow_coat_color0.69073703
92MP0010155_abnormal_intestine_physiology0.68801875
93MP0003880_abnormal_central_pattern0.68564404
94MP0001119_abnormal_female_reproductive0.67421669
95MP0005387_immune_system_phenotype0.67086422
96MP0001790_abnormal_immune_system0.67086422
97MP0005360_urolithiasis0.66878289
98MP0000049_abnormal_middle_ear0.66741913
99MP0003866_abnormal_defecation0.66670287
100MP0006035_abnormal_mitochondrial_morpho0.66254604

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.84437153
2Mitochondrial inheritance (HP:0001427)4.54621107
3Abnormal mitochondria in muscle tissue (HP:0008316)4.34799542
4Acute encephalopathy (HP:0006846)4.07218159
5Increased hepatocellular lipid droplets (HP:0006565)4.03179327
6Progressive macrocephaly (HP:0004481)3.95379284
7Hepatocellular necrosis (HP:0001404)3.94174929
8Increased CSF lactate (HP:0002490)3.92807178
9Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.85041934
10Hepatic necrosis (HP:0002605)3.82319435
11Lipid accumulation in hepatocytes (HP:0006561)3.64206182
12Aplastic anemia (HP:0001915)3.59677327
133-Methylglutaconic aciduria (HP:0003535)3.54685304
14Renal Fanconi syndrome (HP:0001994)3.38014056
15Duplicated collecting system (HP:0000081)3.37107861
16Lactic acidosis (HP:0003128)3.26609274
17Abnormality of the renal collecting system (HP:0004742)3.26462343
18Large for gestational age (HP:0001520)3.19171024
19Cerebral edema (HP:0002181)3.16584447
20Ureteral stenosis (HP:0000071)3.12100264
21Increased serum lactate (HP:0002151)3.04984757
22Pancreatic cysts (HP:0001737)3.03243831
23Increased intramyocellular lipid droplets (HP:0012240)3.03170796
24Abnormality of fatty-acid metabolism (HP:0004359)2.89897369
25Exercise intolerance (HP:0003546)2.88287674
26Ureteral obstruction (HP:0006000)2.84351543
27Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.71554120
28Decreased activity of mitochondrial respiratory chain (HP:0008972)2.69828134
29Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.69828134
30Optic disc pallor (HP:0000543)2.68568882
31Respiratory failure (HP:0002878)2.66250012
32Exertional dyspnea (HP:0002875)2.64268431
33Long foot (HP:0001833)2.61283608
34Abnormality of urine glucose concentration (HP:0011016)2.53358511
35Glycosuria (HP:0003076)2.53358511
36Colon cancer (HP:0003003)2.52770499
37True hermaphroditism (HP:0010459)2.50186430
38Pancreatic fibrosis (HP:0100732)2.50176061
39Adactyly (HP:0009776)2.45483347
40Increased muscle lipid content (HP:0009058)2.41185146
41Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.40424082
42Generalized aminoaciduria (HP:0002909)2.40010890
43Oral leukoplakia (HP:0002745)2.23738674
44Lethargy (HP:0001254)2.21734083
45CNS demyelination (HP:0007305)2.18855560
46Abnormality of midbrain morphology (HP:0002418)2.18584097
47Molar tooth sign on MRI (HP:0002419)2.18584097
48Abnormality of the renal cortex (HP:0011035)2.18475193
49Hypoproteinemia (HP:0003075)2.18309119
50Renal cortical cysts (HP:0000803)2.17183823
51Brushfield spots (HP:0001088)2.16814790
52IgG deficiency (HP:0004315)2.16484162
53Congenital stationary night blindness (HP:0007642)2.16175061
54Hypoplastic pelvis (HP:0008839)2.13676927
55Leukodystrophy (HP:0002415)2.13065185
56Abnormality of renal resorption (HP:0011038)2.12237587
57Methylmalonic aciduria (HP:0012120)2.11485058
58Abnormality of alanine metabolism (HP:0010916)2.08619526
59Hyperalaninemia (HP:0003348)2.08619526
60Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.08619526
61Dry hair (HP:0011359)2.07703886
62Type I transferrin isoform profile (HP:0003642)2.05974055
63Congenital, generalized hypertrichosis (HP:0004540)1.99559508
64Reticulocytopenia (HP:0001896)1.99473247
65Nephronophthisis (HP:0000090)1.96519810
66Hyperphosphaturia (HP:0003109)1.91655334
67Methylmalonic acidemia (HP:0002912)1.89435826
68Myoglobinuria (HP:0002913)1.88707843
69Respiratory difficulties (HP:0002880)1.87526963
70Abnormality of dicarboxylic acid metabolism (HP:0010995)1.87339040
71Dicarboxylic aciduria (HP:0003215)1.87339040
72Abolished electroretinogram (ERG) (HP:0000550)1.86962163
73Abnormal number of erythroid precursors (HP:0012131)1.86082419
74Abnormality of placental membranes (HP:0011409)1.83729447
75Amniotic constriction ring (HP:0009775)1.83729447
76Severe muscular hypotonia (HP:0006829)1.80402540
77Aplasia/hypoplasia of the uterus (HP:0008684)1.79310924
78Severe combined immunodeficiency (HP:0004430)1.78536356
79Increased serum pyruvate (HP:0003542)1.78016585
80Abnormal drinking behavior (HP:0030082)1.77939365
81Polydipsia (HP:0001959)1.77939365
82Metabolic acidosis (HP:0001942)1.77655764
83Autoimmune thrombocytopenia (HP:0001973)1.77612837
84Pancytopenia (HP:0001876)1.77305711
85IgM deficiency (HP:0002850)1.76139807
86Rhabdomyolysis (HP:0003201)1.75062652
87Sclerocornea (HP:0000647)1.74624664
88Abnormality of the prostate (HP:0008775)1.74501513
89Progressive muscle weakness (HP:0003323)1.72398491
90Medial flaring of the eyebrow (HP:0010747)1.70198583
91Broad-based gait (HP:0002136)1.68786748
92Abnormality of cells of the erythroid lineage (HP:0012130)1.67820977
93Abnormality of the renal medulla (HP:0100957)1.66120910
94Clubbing of toes (HP:0100760)1.64295024
95Exercise-induced muscle cramps (HP:0003710)1.62805814
96Chorioretinal coloboma (HP:0000567)1.62752022
97Posterior subcapsular cataract (HP:0007787)1.62047511
98Abnormality of glycolysis (HP:0004366)1.61737584
99Abnormal rod and cone electroretinograms (HP:0008323)1.60030825
100Autoamputation (HP:0001218)1.59054288

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MKNK26.79279383
2MKNK14.26958036
3VRK23.74697678
4TAOK22.87623138
5ZAK2.85412571
6TAOK12.47258225
7TXK2.45936738
8VRK12.33827781
9BUB12.28850807
10MAP3K32.25003205
11MAP3K112.23170657
12MAP4K22.16961535
13SRPK12.11397266
14TLK11.85415440
15WNK41.84952032
16BCKDK1.72097916
17KDR1.70288546
18MST41.69070273
19STK391.66575522
20JAK31.63818797
21STK161.63002681
22NUAK11.54101460
23PINK11.46596930
24ADRBK21.35027532
25TIE11.31788925
26WNK31.30422097
27GRK11.28743335
28TAF11.27335638
29BMPR1B1.23352394
30NME11.13947939
31TRIM281.12627115
32STK241.06770852
33ABL21.05652554
34INSRR1.02001370
35PLK31.01863431
36PRKCQ1.01111919
37EIF2AK30.99739402
38CDC70.99628706
39MAP2K30.99579991
40DYRK1A0.94178853
41TSSK60.94032415
42MAP3K120.89635449
43CCNB10.87549518
44TESK20.86783000
45CHEK20.86206570
46CSNK1G30.85825339
47TAOK30.82423720
48OBSCN0.81519245
49PASK0.79237899
50DYRK20.77855121
51MAP3K50.77153116
52CDK190.75496064
53NEK10.75371696
54EPHB20.70654734
55CSNK1G10.69451449
56OXSR10.67488036
57BCR0.65624322
58MAPKAPK50.64757822
59CSNK1G20.61724883
60CSNK1A1L0.59405173
61CDK80.59310248
62MUSK0.57530526
63ITK0.51538551
64PHKG20.48388802
65PHKG10.48388802
66CSNK1A10.48228344
67FES0.46906310
68RPS6KA50.44235816
69MAP2K70.43879826
70FRK0.43594708
71PIK3CG0.42936230
72PBK0.42826351
73PLK40.42157307
74EIF2AK20.40965711
75PDK20.40740241
76GRK50.39532843
77DAPK30.39409529
78MYLK0.38425043
79RPS6KA40.38375574
80DAPK10.38365592
81GRK70.37436946
82AURKA0.37360530
83PLK20.36481963
84CSNK2A10.35827478
85TGFBR10.35809000
86ILK0.35588611
87WEE10.35005184
88CSNK2A20.34234131
89MAP4K10.33685603
90MAPKAPK30.33356675
91ERBB30.32731717
92TEC0.30340357
93ADRBK10.30156904
94PLK10.29948477
95ATR0.27978926
96AURKB0.27612815
97LIMK10.26180521
98PRKCE0.25687248
99SYK0.24299613
100PRKCA0.24149618

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.24372114
2Oxidative phosphorylation_Homo sapiens_hsa001903.81483210
3Parkinsons disease_Homo sapiens_hsa050123.26972291
4RNA polymerase_Homo sapiens_hsa030203.11744484
5Ribosome_Homo sapiens_hsa030102.93044574
6Protein export_Homo sapiens_hsa030602.51937670
7Huntingtons disease_Homo sapiens_hsa050162.23057260
8Alzheimers disease_Homo sapiens_hsa050102.11750127
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.01906515
10Primary immunodeficiency_Homo sapiens_hsa053401.88015284
11SNARE interactions in vesicular transport_Homo sapiens_hsa041301.81661325
12Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.77962695
13Mismatch repair_Homo sapiens_hsa034301.73344050
14Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.65415227
15Cardiac muscle contraction_Homo sapiens_hsa042601.64710929
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.64644280
17Fatty acid elongation_Homo sapiens_hsa000621.60209153
18Homologous recombination_Homo sapiens_hsa034401.58014754
19Propanoate metabolism_Homo sapiens_hsa006401.51861887
20Autoimmune thyroid disease_Homo sapiens_hsa053201.50046995
21DNA replication_Homo sapiens_hsa030301.49051876
22Pyrimidine metabolism_Homo sapiens_hsa002401.48455911
23One carbon pool by folate_Homo sapiens_hsa006701.46833530
24Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.42058426
25Allograft rejection_Homo sapiens_hsa053301.40724745
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.39220488
27Asthma_Homo sapiens_hsa053101.34193568
28Nucleotide excision repair_Homo sapiens_hsa034201.33894240
29Graft-versus-host disease_Homo sapiens_hsa053321.31090997
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.30512950
31Butanoate metabolism_Homo sapiens_hsa006501.29479646
32RNA degradation_Homo sapiens_hsa030181.23666144
33Non-homologous end-joining_Homo sapiens_hsa034501.20521201
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.17249052
35Type I diabetes mellitus_Homo sapiens_hsa049401.14856209
36Systemic lupus erythematosus_Homo sapiens_hsa053221.11316147
37RNA transport_Homo sapiens_hsa030131.09883001
38Antigen processing and presentation_Homo sapiens_hsa046121.09273146
39Intestinal immune network for IgA production_Homo sapiens_hsa046721.08753702
40Basal transcription factors_Homo sapiens_hsa030221.08306944
41Purine metabolism_Homo sapiens_hsa002301.07797499
422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.07777014
43Spliceosome_Homo sapiens_hsa030401.07092669
44Peroxisome_Homo sapiens_hsa041461.06243967
45Phototransduction_Homo sapiens_hsa047441.01894607
46Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.96962066
47Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.95288726
48Caffeine metabolism_Homo sapiens_hsa002320.89998757
49Linoleic acid metabolism_Homo sapiens_hsa005910.89155848
50Sulfur metabolism_Homo sapiens_hsa009200.87257781
51Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.87244264
52Tryptophan metabolism_Homo sapiens_hsa003800.86106845
53Base excision repair_Homo sapiens_hsa034100.85763414
54Rheumatoid arthritis_Homo sapiens_hsa053230.85701768
55Fanconi anemia pathway_Homo sapiens_hsa034600.83339640
56Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.82746389
57Nitrogen metabolism_Homo sapiens_hsa009100.77316473
58Hematopoietic cell lineage_Homo sapiens_hsa046400.74842923
59Cysteine and methionine metabolism_Homo sapiens_hsa002700.73982037
60Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.72252945
61Metabolic pathways_Homo sapiens_hsa011000.71746652
62Pyruvate metabolism_Homo sapiens_hsa006200.68951264
63Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.68451506
64beta-Alanine metabolism_Homo sapiens_hsa004100.67952214
65Carbon metabolism_Homo sapiens_hsa012000.67693750
66Glutathione metabolism_Homo sapiens_hsa004800.67478022
67Maturity onset diabetes of the young_Homo sapiens_hsa049500.66263516
68Collecting duct acid secretion_Homo sapiens_hsa049660.65316431
69Taste transduction_Homo sapiens_hsa047420.60134188
70Biosynthesis of amino acids_Homo sapiens_hsa012300.60007021
71Chemical carcinogenesis_Homo sapiens_hsa052040.59925102
72Folate biosynthesis_Homo sapiens_hsa007900.59168318
73Steroid biosynthesis_Homo sapiens_hsa001000.58331079
74Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.58137166
75Vitamin digestion and absorption_Homo sapiens_hsa049770.56307101
76Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.55960919
77Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.55731690
78Pentose and glucuronate interconversions_Homo sapiens_hsa000400.55495647
79alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.53738152
80Retinol metabolism_Homo sapiens_hsa008300.53733767
81Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.51831851
82Arginine biosynthesis_Homo sapiens_hsa002200.51601372
83Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.50531018
84Drug metabolism - other enzymes_Homo sapiens_hsa009830.50251458
85Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.49183658
86Selenocompound metabolism_Homo sapiens_hsa004500.46795853
87Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.44469114
88Cyanoamino acid metabolism_Homo sapiens_hsa004600.44302221
89Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44127552
90Viral myocarditis_Homo sapiens_hsa054160.43974543
91Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.42801701
92Fatty acid degradation_Homo sapiens_hsa000710.42121724
93Arginine and proline metabolism_Homo sapiens_hsa003300.40113036
94Fat digestion and absorption_Homo sapiens_hsa049750.39135312
95Alcoholism_Homo sapiens_hsa050340.38662803
96Arachidonic acid metabolism_Homo sapiens_hsa005900.37413874
97Epstein-Barr virus infection_Homo sapiens_hsa051690.36266290
98Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.35436092
99Glycerolipid metabolism_Homo sapiens_hsa005610.33355862
100Steroid hormone biosynthesis_Homo sapiens_hsa001400.31639229

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