GAPDHP14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of vitamin D biosynthetic process (GO:0060556)6.13635823
2negative regulation of interleukin-12 production (GO:0032695)5.30736613
3regulation of chronic inflammatory response (GO:0002676)5.27670473
4proteasome assembly (GO:0043248)5.17194612
5regulation of vitamin metabolic process (GO:0030656)4.75521640
6positive regulation of heat generation (GO:0031652)4.72304832
7regulation of fever generation (GO:0031620)4.64462818
8regulation of cytokine secretion involved in immune response (GO:0002739)4.33852111
9regulation of T-helper 1 cell differentiation (GO:0045625)4.20806719
10muscle cell cellular homeostasis (GO:0046716)3.95584562
11positive regulation of chemokine biosynthetic process (GO:0045080)3.90270999
12positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.90053925
13regulation of podosome assembly (GO:0071801)3.85904087
14regulation of interleukin-8 biosynthetic process (GO:0045414)3.74798876
15response to peptidoglycan (GO:0032494)3.67845504
16regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.57919425
17modulation of growth of symbiont involved in interaction with host (GO:0044144)3.57317419
18regulation of growth of symbiont in host (GO:0044126)3.57317419
19negative regulation of growth of symbiont in host (GO:0044130)3.57317419
20negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.57317419
21NIK/NF-kappaB signaling (GO:0038061)3.56351846
22positive regulation of humoral immune response (GO:0002922)3.56285353
23regulation of chemokine biosynthetic process (GO:0045073)3.52092718
24regulation of immunoglobulin secretion (GO:0051023)3.50504853
25positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.48829156
26plasma membrane fusion (GO:0045026)3.48243693
27regulation of heat generation (GO:0031650)3.47023649
28regulation of interferon-alpha production (GO:0032647)3.44390361
29regulation of interleukin-12 production (GO:0032655)3.40326538
30germinal center formation (GO:0002467)3.40192470
31immunoglobulin mediated immune response (GO:0016064)3.31470256
32negative regulation of monooxygenase activity (GO:0032769)3.29238908
33positive regulation of NF-kappaB import into nucleus (GO:0042346)3.28950220
34negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.27423411
35neutrophil activation involved in immune response (GO:0002283)3.27014335
36myeloid dendritic cell differentiation (GO:0043011)3.24794702
37cellular response to type I interferon (GO:0071357)3.23589907
38type I interferon signaling pathway (GO:0060337)3.23589907
39positive regulation of defense response to virus by host (GO:0002230)3.21859307
40branching involved in labyrinthine layer morphogenesis (GO:0060670)3.19355847
41regulation of inflammatory response to antigenic stimulus (GO:0002861)3.18801968
42response to type I interferon (GO:0034340)3.18078188
43positive regulation of toll-like receptor signaling pathway (GO:0034123)3.17383397
44regulation of prostaglandin secretion (GO:0032306)3.13379854
45regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.12410119
46positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.09318381
47negative regulation of cytokine production involved in immune response (GO:0002719)3.00684787
48lipopolysaccharide-mediated signaling pathway (GO:0031663)2.98815361
49positive regulation of prostaglandin secretion (GO:0032308)2.96080858
50regulation of dendritic cell antigen processing and presentation (GO:0002604)2.93837429
51positive regulation of interleukin-6 production (GO:0032755)2.93821008
52purine nucleotide salvage (GO:0032261)2.92968320
53positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.92566784
54positive regulation of interleukin-12 production (GO:0032735)2.91030059
55positive regulation of acute inflammatory response (GO:0002675)2.90816325
56dendritic cell differentiation (GO:0097028)2.90315212
57regulation of mononuclear cell migration (GO:0071675)2.90223259
58interferon-gamma secretion (GO:0072643)2.84727865
59monocyte chemotaxis (GO:0002548)2.84166693
60positive regulation of interleukin-1 beta secretion (GO:0050718)2.83930243
61regulation of nitric oxide biosynthetic process (GO:0045428)2.83199628
62positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.83156703
63myeloid dendritic cell activation (GO:0001773)2.82934525
64protein maturation by protein folding (GO:0022417)2.82244714
65positive regulation of nitric oxide biosynthetic process (GO:0045429)2.79807422
66T-helper 1 type immune response (GO:0042088)2.79463271
67bundle of His cell to Purkinje myocyte communication (GO:0086069)2.79238082
68positive regulation of leukocyte apoptotic process (GO:2000108)2.78674469
69regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.75948985
70regulation of interleukin-1 beta secretion (GO:0050706)2.75922852
71regulation of NF-kappaB import into nucleus (GO:0042345)2.75767525
72B cell mediated immunity (GO:0019724)2.74569028
73regulation of heterotypic cell-cell adhesion (GO:0034114)2.74504563
74positive regulation of interferon-alpha production (GO:0032727)2.74414617
75negative regulation of nitric oxide biosynthetic process (GO:0045019)2.73825679
76negative regulation of viral genome replication (GO:0045071)2.73169199
77regulation of interleukin-6 biosynthetic process (GO:0045408)2.72838626
78interferon-gamma-mediated signaling pathway (GO:0060333)2.68212023
79natural killer cell mediated immunity (GO:0002228)2.68181286
80natural killer cell mediated cytotoxicity (GO:0042267)2.68181286
81response to protozoan (GO:0001562)2.66750743
82cellular response to molecule of bacterial origin (GO:0071219)2.66314034
83cellular response to lipopolysaccharide (GO:0071222)2.64421812
84regulation of antigen processing and presentation (GO:0002577)2.64393791
85defense response to protozoan (GO:0042832)2.63912844
86antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.62428113
87regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.62352082
88positive regulation of lymphocyte apoptotic process (GO:0070230)2.61143101
89antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.60818611
90regulation of gonadotropin secretion (GO:0032276)2.60453511
91regulation of T-helper cell differentiation (GO:0045622)2.60361576
92positive regulation of interleukin-1 secretion (GO:0050716)2.60216908
93regulation of meiosis I (GO:0060631)2.60042674
94modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.58058770
95positive regulation by organism of defense response of other organism involved in symbiotic interact2.58058770
96modulation by symbiont of host immune response (GO:0052553)2.58058770
97positive regulation by symbiont of host defense response (GO:0052509)2.58058770
98modulation by symbiont of host defense response (GO:0052031)2.58058770
99modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.58058770
100regulation of interleukin-12 biosynthetic process (GO:0045075)2.57201790

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.36612598
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.72594440
3IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.91011997
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.65649686
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.34120818
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.06526486
7RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.03489488
8IRF8_27001747_Chip-Seq_BMDM_Mouse2.95502702
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.84851292
10STAT4_19710469_ChIP-ChIP_TH1__Mouse2.78516049
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.78479990
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.55798529
13SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.54079306
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.37170623
15TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.30858150
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.29723772
17NOTCH1_21737748_ChIP-Seq_TLL_Human2.29433181
18JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.18043304
19SRF_21415370_ChIP-Seq_HL-1_Mouse2.17120524
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.11436998
21Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.08885693
22SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.06650597
23ELF1_17652178_ChIP-ChIP_JURKAT_Human2.02077425
24FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.01695137
25STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.98242639
26NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.87967761
27SPI1_23547873_ChIP-Seq_NB4_Human1.86151498
28MYB_21317192_ChIP-Seq_ERMYB_Mouse1.80203338
29STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.79683121
30CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.68672026
31NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.67580317
32SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.66806018
33VDR_23849224_ChIP-Seq_CD4+_Human1.66046932
34SMAD_19615063_ChIP-ChIP_OVARY_Human1.63503084
35ELK1_19687146_ChIP-ChIP_HELA_Human1.63382677
36HOXB4_20404135_ChIP-ChIP_EML_Mouse1.62961006
37MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.60868012
38EGR1_23403033_ChIP-Seq_LIVER_Mouse1.58680386
39ETS1_20019798_ChIP-Seq_JURKAT_Human1.52673011
40CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.52474698
41ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.50571832
42GATA3_26560356_Chip-Seq_TH2_Human1.48631151
43VDR_22108803_ChIP-Seq_LS180_Human1.47636331
44HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.44213735
45SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.39200909
46EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.33335348
47RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.33054871
48PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.32993007
49ELK1_22589737_ChIP-Seq_MCF10A_Human1.30894255
50CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.28858140
51VDR_24787735_ChIP-Seq_THP-1_Human1.28024997
52LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.27529958
53TFEB_21752829_ChIP-Seq_HELA_Human1.27021932
54CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.25052121
55STAT3_1855785_ChIP-Seq_MESCs_Mouse1.24299735
56PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.24015252
57CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.21738522
58KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.20746821
59KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.20746821
60KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.20746821
61BRD4_27068464_Chip-Seq_AML-cells_Mouse1.18017296
62STAT1_20625510_ChIP-Seq_HELA_Human1.17576769
63GATA2_21666600_ChIP-Seq_HMVEC_Human1.17182313
64STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.15093987
65SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15068949
66PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14344639
67FLI1_27457419_Chip-Seq_LIVER_Mouse1.09774563
68FOXP3_21729870_ChIP-Seq_TREG_Human1.09400329
69CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08416835
70MYB_26560356_Chip-Seq_TH2_Human1.07375341
71STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.05413850
72NFE2_27457419_Chip-Seq_LIVER_Mouse1.05204359
73LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.04642629
74SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.03905511
75E2F1_18555785_ChIP-Seq_MESCs_Mouse1.03166573
76SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.01767764
77ERG_20887958_ChIP-Seq_HPC-7_Mouse0.99342011
78NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.99227494
79CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98477103
80CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96644501
81PCGF2_27294783_Chip-Seq_ESCs_Mouse0.96446423
82TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.93863943
83MYC_18358816_ChIP-ChIP_MESCs_Mouse0.93603437
84PU_27001747_Chip-Seq_BMDM_Mouse0.92803912
85MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.92356759
86HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.91941737
87TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.91260241
88PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.90960561
89RUNX_20019798_ChIP-Seq_JUKART_Human0.90594870
90PCGF2_27294783_Chip-Seq_NPCs_Mouse0.90097460
91TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89715226
92GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.88925776
93DCP1A_22483619_ChIP-Seq_HELA_Human0.87373436
94NANOG_19829295_ChIP-Seq_ESCs_Human0.87365178
95SOX2_19829295_ChIP-Seq_ESCs_Human0.87365178
96FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.87173470
97MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.86662515
98CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.82065869
99MYC_19030024_ChIP-ChIP_MESCs_Mouse0.81972519
100YY1_21170310_ChIP-Seq_MESCs_Mouse0.81890339

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation4.62343656
2MP0004510_myositis4.49781909
3MP0002163_abnormal_gland_morphology3.85092184
4MP0001835_abnormal_antigen_presentation3.39893521
5MP0003724_increased_susceptibility_to3.39693714
6MP0002148_abnormal_hypersensitivity_rea3.37336182
7MP0003950_abnormal_plasma_membrane3.25500605
8MP0009785_altered_susceptibility_to3.22200744
9MP0003436_decreased_susceptibility_to3.10800405
10MP0006082_CNS_inflammation2.81390191
11MP0003806_abnormal_nucleotide_metabolis2.71890416
12MP0002736_abnormal_nociception_after2.60542380
13MP0000749_muscle_degeneration2.55312409
14MP0009764_decreased_sensitivity_to2.54472067
15MP0001790_abnormal_immune_system2.50569633
16MP0005387_immune_system_phenotype2.50569633
17MP0005671_abnormal_response_to2.40200780
18MP0005000_abnormal_immune_tolerance2.38364272
19MP0002254_reproductive_system_inflammat2.37616417
20MP0005167_abnormal_blood-brain_barrier2.29829008
21MP0005058_abnormal_lysosome_morphology2.09067300
22MP0005379_endocrine/exocrine_gland_phen2.08174741
23MP0002419_abnormal_innate_immunity2.07889943
24MP0005025_abnormal_response_to1.97227950
25MP0006054_spinal_hemorrhage1.94392074
26MP0002332_abnormal_exercise_endurance1.93010372
27MP0002452_abnormal_antigen_presenting1.92059369
28MP0001800_abnormal_humoral_immune1.89565521
29MP0003075_altered_response_to1.87527758
30MP0002723_abnormal_immune_serum1.86026351
31MP0003300_gastrointestinal_ulcer1.85356745
32MP0008004_abnormal_stomach_pH1.77607976
33MP0001533_abnormal_skeleton_physiology1.75132934
34MP0000685_abnormal_immune_system1.74190144
35MP0003646_muscle_fatigue1.73895664
36MP0002138_abnormal_hepatobiliary_system1.70316959
37MP0010155_abnormal_intestine_physiology1.48494384
38MP0008469_abnormal_protein_level1.47885836
39MP0001845_abnormal_inflammatory_respons1.46597571
40MP0001819_abnormal_immune_cell1.45792099
41MP0004947_skin_inflammation1.45232085
42MP0001853_heart_inflammation1.45091974
43MP0002420_abnormal_adaptive_immunity1.43903283
44MP0005310_abnormal_salivary_gland1.41567479
45MP0002405_respiratory_system_inflammati1.30720584
46MP0003195_calcinosis1.30205496
47MP0000343_altered_response_to1.26435104
48MP0003448_altered_tumor_morphology1.25879125
49MP0001968_abnormal_touch/_nociception1.23687718
50MP0005451_abnormal_body_composition1.20637678
51MP0008260_abnormal_autophagy1.19846045
52MP0003172_abnormal_lysosome_physiology1.12218999
53MP0005166_decreased_susceptibility_to1.10398916
54MP0005165_increased_susceptibility_to1.08859119
55MP0002139_abnormal_hepatobiliary_system1.07218651
56MP0002277_abnormal_respiratory_mucosa1.05850727
57MP0009333_abnormal_splenocyte_physiolog1.05634968
58MP0003186_abnormal_redox_activity0.99437029
59MP0003718_maternal_effect0.96402588
60MP0005464_abnormal_platelet_physiology0.96247475
61MP0001542_abnormal_bone_strength0.94247918
62MP0005319_abnormal_enzyme/_coenzyme0.93795896
63MP0002132_abnormal_respiratory_system0.93423954
64MP0000716_abnormal_immune_system0.93311795
65MP0005164_abnormal_response_to0.90682716
66MP0002006_tumorigenesis0.87532494
67MP0004084_abnormal_cardiac_muscle0.86558750
68MP0005075_abnormal_melanosome_morpholog0.85365074
69MP0009840_abnormal_foam_cell0.84986074
70MP0008058_abnormal_DNA_repair0.84822086
71MP0001501_abnormal_sleep_pattern0.80199143
72MP0008875_abnormal_xenobiotic_pharmacok0.80147202
73MP0002933_joint_inflammation0.79910844
74MP0002398_abnormal_bone_marrow0.77449988
75MP0003453_abnormal_keratinocyte_physiol0.77286121
76MP0000015_abnormal_ear_pigmentation0.76750219
77MP0003828_pulmonary_edema0.76498890
78MP0002429_abnormal_blood_cell0.73886246
79MP0009763_increased_sensitivity_to0.72750101
80MP0004883_abnormal_blood_vessel0.72610720
81MP0000858_altered_metastatic_potential0.72037199
82MP0009765_abnormal_xenobiotic_induced0.71693148
83MP0001663_abnormal_digestive_system0.70916951
84MP0005084_abnormal_gallbladder_morpholo0.70038082
85MP0001764_abnormal_homeostasis0.69558469
86MP0003011_delayed_dark_adaptation0.69080135
87MP0000689_abnormal_spleen_morphology0.68409767
88MP0005266_abnormal_metabolism0.66877973
89MP0002722_abnormal_immune_system0.65560234
90MP0000613_abnormal_salivary_gland0.65435419
91MP0006036_abnormal_mitochondrial_physio0.62916411
92MP0006035_abnormal_mitochondrial_morpho0.58914747
93MP0001545_abnormal_hematopoietic_system0.58841987
94MP0005397_hematopoietic_system_phenotyp0.58841987
95MP0009278_abnormal_bone_marrow0.57637041
96MP0000358_abnormal_cell_content/0.56398190
97MP0005390_skeleton_phenotype0.55902176
98MP0002972_abnormal_cardiac_muscle0.55780880
99MP0005410_abnormal_fertilization0.55365248
100MP0010352_gastrointestinal_tract_polyps0.54969776

Predicted human phenotypes

RankGene SetZ-score
1Type 2 muscle fiber atrophy (HP:0003554)5.21023688
2Stomatitis (HP:0010280)5.17875443
3Amniotic constriction ring (HP:0009775)5.05604236
4Abnormality of placental membranes (HP:0011409)5.05604236
5Muscle fiber atrophy (HP:0100295)4.80560293
6Retrobulbar optic neuritis (HP:0100654)4.26153453
7Optic neuritis (HP:0100653)4.26153453
8Popliteal pterygium (HP:0009756)3.99352161
9Orchitis (HP:0100796)3.91487728
10Aplasia of the musculature (HP:0100854)3.87836563
11Abnormality of glycolipid metabolism (HP:0010969)3.72159185
12Abnormality of liposaccharide metabolism (HP:0010968)3.72159185
13Abnormality of glycosphingolipid metabolism (HP:0004343)3.72159185
14Calf muscle hypertrophy (HP:0008981)3.63700593
15Myositis (HP:0100614)3.44359459
16Dyschromatopsia (HP:0007641)3.42261801
17Malignant hyperthermia (HP:0002047)3.27402258
18Parakeratosis (HP:0001036)3.19590680
19Elevated erythrocyte sedimentation rate (HP:0003565)3.16860349
20Muscle hypertrophy of the lower extremities (HP:0008968)3.15708591
21Weak cry (HP:0001612)2.94549529
22Fetal akinesia sequence (HP:0001989)2.91329718
23Abnormality of macrophages (HP:0004311)2.89355162
24Keratoconjunctivitis sicca (HP:0001097)2.83737978
25Aplasia/Hypoplasia involving the musculature (HP:0001460)2.80066088
26Horizontal nystagmus (HP:0000666)2.79632604
27Vacuolated lymphocytes (HP:0001922)2.75989331
28Autoimmune thrombocytopenia (HP:0001973)2.75263947
29Increased IgM level (HP:0003496)2.74922660
30Prostate neoplasm (HP:0100787)2.72669796
31Asymmetric septal hypertrophy (HP:0001670)2.70401528
32Abnormality of the neuromuscular junction (HP:0003398)2.69617425
33Fatigable weakness (HP:0003473)2.69617425
34Gangrene (HP:0100758)2.65487382
35Generalized aminoaciduria (HP:0002909)2.64699162
36Acute necrotizing encephalopathy (HP:0006965)2.62602820
37Gastrointestinal infarctions (HP:0005244)2.60308426
38Nausea (HP:0002018)2.60112728
39Keratoconjunctivitis (HP:0001096)2.58621426
40Recurrent bacterial skin infections (HP:0005406)2.57038848
41Late onset (HP:0003584)2.53514918
42Recurrent abscess formation (HP:0002722)2.49104450
43Gowers sign (HP:0003391)2.49003309
44Sudden death (HP:0001699)2.48826478
45Hepatosplenomegaly (HP:0001433)2.43888579
46Renal Fanconi syndrome (HP:0001994)2.41576472
47Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.39563416
48Increased CSF lactate (HP:0002490)2.38124500
49Hemoptysis (HP:0002105)2.37320233
50Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.36555650
51Loss of speech (HP:0002371)2.36436530
52Mitochondrial inheritance (HP:0001427)2.36411477
53Exertional dyspnea (HP:0002875)2.33146706
54Vasculitis (HP:0002633)2.32993223
55Dysostosis multiplex (HP:0000943)2.32287595
56Nemaline bodies (HP:0003798)2.30934902
57Poor suck (HP:0002033)2.27479036
58Abnormal mitochondria in muscle tissue (HP:0008316)2.25620770
59Hepatic necrosis (HP:0002605)2.23697507
60Episodic fever (HP:0001954)2.22028353
61Albinism (HP:0001022)2.21005384
62Oral leukoplakia (HP:0002745)2.20482785
63Hepatocellular necrosis (HP:0001404)2.19086019
64Progressive macrocephaly (HP:0004481)2.14707289
65Akinesia (HP:0002304)2.13869349
66Amaurosis fugax (HP:0100576)2.10794250
67Acute encephalopathy (HP:0006846)2.08037133
68Abnormality of the calf musculature (HP:0001430)2.05763936
69Increased hepatocellular lipid droplets (HP:0006565)2.05518304
70Abnormality of the basal ganglia (HP:0002134)2.02983923
71Anorexia (HP:0002039)2.02923473
72Rough bone trabeculation (HP:0100670)2.02772433
73Distal arthrogryposis (HP:0005684)2.01189584
74Pulmonary infiltrates (HP:0002113)1.98592912
75Premature loss of primary teeth (HP:0006323)1.98031556
76Lipid accumulation in hepatocytes (HP:0006561)1.89475542
77Ulnar deviation of the wrist (HP:0003049)1.86061913
78Basal ganglia calcification (HP:0002135)1.85704256
79Increased cerebral lipofuscin (HP:0011813)1.85658896
80Respiratory difficulties (HP:0002880)1.84303061
81Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.81528499
82Diminished movement (HP:0002374)1.81441160
83Degeneration of anterior horn cells (HP:0002398)1.79889960
84Abnormality of the anterior horn cell (HP:0006802)1.79889960
85Trismus (HP:0000211)1.79750030
86Abnormality of B cell number (HP:0010975)1.79628235
87Arterial thrombosis (HP:0004420)1.76825821
88Cholecystitis (HP:0001082)1.76734872
89Abnormal gallbladder physiology (HP:0012438)1.76734872
90Polyneuropathy (HP:0001271)1.76673119
91Abnormal trabecular bone morphology (HP:0100671)1.75586441
92Bulbar palsy (HP:0001283)1.75462234
93Progressive neurologic deterioration (HP:0002344)1.75301197
94Cleft eyelid (HP:0000625)1.75295851
95Abnormality of methionine metabolism (HP:0010901)1.75146615
96Exercise-induced muscle cramps (HP:0003710)1.74104159
97Mutism (HP:0002300)1.73727049
98Glomerulopathy (HP:0100820)1.73295849
99Agnosia (HP:0010524)1.73146044
100Myocardial infarction (HP:0001658)1.72813268

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK34.33748649
2TLK13.28415239
3NME22.88504522
4MAP3K142.52587070
5BMPR1B2.41300082
6VRK22.35029777
7GRK72.34699167
8PDK22.33635416
9TXK2.19141276
10LMTK22.11071363
11IKBKB1.95389871
12MOS1.93375583
13BUB11.89516909
14VRK11.88193370
15DDR21.87870226
16IRAK41.85590224
17ACVR1B1.85117391
18PLK21.84559786
19EIF2AK31.80742804
20ZAK1.79807330
21OBSCN1.76327247
22MATK1.74765227
23TBK11.72322029
24PIK3CG1.70097530
25BLK1.69969777
26NEK11.60281777
27MST41.55521464
28JAK31.51227862
29MAP4K11.48535892
30TRIM281.48009865
31RIPK41.47830182
32ARAF1.46983805
33TYK21.46112453
34MAP3K91.39624284
35SIK31.36333016
36TAOK21.35270254
37IKBKE1.33633139
38SMG11.27611892
39BMPR21.20653390
40ADRBK21.18684665
41CSK1.16526753
42MAP3K31.13773086
43TAF11.08886344
44PLK31.08306494
45MAP3K131.07628236
46EIF2AK11.02569935
47CHUK1.01476182
48IRAK10.98110991
49PBK0.96569405
50CDK90.93790117
51PIM20.92855124
52BCKDK0.92816074
53FGR0.92812224
54TAOK30.92528516
55NUAK10.92026124
56MAP3K50.91423820
57PTK2B0.88358903
58SYK0.85299941
59EIF2AK20.85271842
60STK100.81419572
61LIMK10.80258514
62PAK40.73079824
63GRK10.72974218
64CSNK1G20.72114871
65MARK30.71806004
66LYN0.67498276
67MAP3K110.67460158
68STK240.67432934
69PRKG20.66310313
70ABL20.65282067
71CDK190.64434318
72CSNK1G30.64246817
73DAPK30.63733860
74MAP3K120.63719687
75OXSR10.58886327
76PIM10.58768746
77STK160.58323776
78TIE10.57280650
79EGFR0.53574248
80DAPK10.52328864
81PKN10.49973442
82RIPK10.49292497
83KIT0.47861438
84AURKA0.45748983
85CCNB10.40743946
86STK390.38794310
87JAK20.37596195
88IRAK20.36123746
89LCK0.34699048
90HCK0.33043998
91CSF1R0.32657708
92CSNK1A1L0.31876703
93ABL10.30477366
94BTK0.29178282
95MAPK70.29073715
96TAOK10.28290776
97TNIK0.26574199
98STK40.26130315
99INSRR0.25430895
100NEK90.24901333

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.86488537
2Asthma_Homo sapiens_hsa053103.13094964
3Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.83854885
4Rheumatoid arthritis_Homo sapiens_hsa053232.83130819
5NF-kappa B signaling pathway_Homo sapiens_hsa040642.75112214
6Allograft rejection_Homo sapiens_hsa053302.66993672
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.49530922
8Legionellosis_Homo sapiens_hsa051342.41545960
9Toll-like receptor signaling pathway_Homo sapiens_hsa046202.35200669
10Graft-versus-host disease_Homo sapiens_hsa053322.31058625
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.20627518
12Leishmaniasis_Homo sapiens_hsa051402.19811455
13Malaria_Homo sapiens_hsa051442.11430691
14NOD-like receptor signaling pathway_Homo sapiens_hsa046212.09848213
15Autoimmune thyroid disease_Homo sapiens_hsa053202.04030166
16Osteoclast differentiation_Homo sapiens_hsa043801.97208498
17Pertussis_Homo sapiens_hsa051331.85095265
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.80271287
19Type I diabetes mellitus_Homo sapiens_hsa049401.79916533
20Protein export_Homo sapiens_hsa030601.70948829
21Staphylococcus aureus infection_Homo sapiens_hsa051501.69265293
22Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.68368071
23African trypanosomiasis_Homo sapiens_hsa051431.61772344
24Tuberculosis_Homo sapiens_hsa051521.60942143
25TNF signaling pathway_Homo sapiens_hsa046681.59683205
26Hematopoietic cell lineage_Homo sapiens_hsa046401.54490849
27Influenza A_Homo sapiens_hsa051641.52405603
28Fatty acid elongation_Homo sapiens_hsa000621.48757067
29Lysosome_Homo sapiens_hsa041421.47638706
30Viral myocarditis_Homo sapiens_hsa054161.44464220
31Systemic lupus erythematosus_Homo sapiens_hsa053221.43685866
32Herpes simplex infection_Homo sapiens_hsa051681.39467253
33Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.32802867
34Oxidative phosphorylation_Homo sapiens_hsa001901.29944997
35SNARE interactions in vesicular transport_Homo sapiens_hsa041301.24238161
36Measles_Homo sapiens_hsa051621.21936816
37Phagosome_Homo sapiens_hsa041451.20709109
38Basal transcription factors_Homo sapiens_hsa030221.16278344
39Collecting duct acid secretion_Homo sapiens_hsa049661.13542966
40Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.13472826
41Parkinsons disease_Homo sapiens_hsa050121.11238413
42Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.06969653
43Antigen processing and presentation_Homo sapiens_hsa046121.06878351
44Folate biosynthesis_Homo sapiens_hsa007901.06157096
45Epstein-Barr virus infection_Homo sapiens_hsa051691.04064162
46Glycosaminoglycan degradation_Homo sapiens_hsa005311.03758113
47Other glycan degradation_Homo sapiens_hsa005111.02378800
48Sulfur metabolism_Homo sapiens_hsa009200.96747372
49Mismatch repair_Homo sapiens_hsa034300.96563070
50Primary immunodeficiency_Homo sapiens_hsa053400.93063063
51Salmonella infection_Homo sapiens_hsa051320.92932722
52Toxoplasmosis_Homo sapiens_hsa051450.92712277
53Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.88003975
54Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.86997266
55DNA replication_Homo sapiens_hsa030300.85812028
56Jak-STAT signaling pathway_Homo sapiens_hsa046300.83032048
57Vibrio cholerae infection_Homo sapiens_hsa051100.83028786
58Homologous recombination_Homo sapiens_hsa034400.78361642
59Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.74643315
60Pentose phosphate pathway_Homo sapiens_hsa000300.72032124
61Caffeine metabolism_Homo sapiens_hsa002320.70911656
62Shigellosis_Homo sapiens_hsa051310.70443699
63Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.68200203
64Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.67519232
65Glutathione metabolism_Homo sapiens_hsa004800.64238981
66Hepatitis B_Homo sapiens_hsa051610.60517661
67Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.59768337
68Viral carcinogenesis_Homo sapiens_hsa052030.59401889
69RNA degradation_Homo sapiens_hsa030180.58790006
70RNA polymerase_Homo sapiens_hsa030200.58395820
71Alzheimers disease_Homo sapiens_hsa050100.57736955
72Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.57445780
73Apoptosis_Homo sapiens_hsa042100.55770341
74Huntingtons disease_Homo sapiens_hsa050160.55141094
75Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.53359126
76Base excision repair_Homo sapiens_hsa034100.53136892
77Nucleotide excision repair_Homo sapiens_hsa034200.53093269
78Pyrimidine metabolism_Homo sapiens_hsa002400.52598591
79Hepatitis C_Homo sapiens_hsa051600.50324059
80Tryptophan metabolism_Homo sapiens_hsa003800.49170235
81Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.47567388
82Chemokine signaling pathway_Homo sapiens_hsa040620.46809864
83Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46214455
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.45308551
85Cysteine and methionine metabolism_Homo sapiens_hsa002700.41149077
86p53 signaling pathway_Homo sapiens_hsa041150.37902423
87Fatty acid biosynthesis_Homo sapiens_hsa000610.36512496
88Ribosome_Homo sapiens_hsa030100.34421522
89Prion diseases_Homo sapiens_hsa050200.32628811
90Galactose metabolism_Homo sapiens_hsa000520.32623932
91Amoebiasis_Homo sapiens_hsa051460.32142495
92Bladder cancer_Homo sapiens_hsa052190.29794082
93Purine metabolism_Homo sapiens_hsa002300.29200967
94B cell receptor signaling pathway_Homo sapiens_hsa046620.26924495
95HTLV-I infection_Homo sapiens_hsa051660.26579138
96Primary bile acid biosynthesis_Homo sapiens_hsa001200.26347058
97Complement and coagulation cascades_Homo sapiens_hsa046100.26127810
98Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.25691377
99Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.25595874
100Cardiac muscle contraction_Homo sapiens_hsa042600.25112969

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