ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of sister chromatid cohesion (GO:0007063)	9.74090178
2	eosinophil migration (GO:0072677)	9.65243212
3	negative regulation of peptidyl-threonine phosphorylation (GO:0010801)	9.55327084
4	regulation of mononuclear cell migration (GO:0071675)	9.33206237
5	branch elongation of an epithelium (GO:0060602)	8.45215060
6	negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)	8.13775061
7	positive regulation of chromosome segregation (GO:0051984)	7.99012335
8	L-fucose catabolic process (GO:0042355)	7.88368710
9	fucose catabolic process (GO:0019317)	7.88368710
10	L-fucose metabolic process (GO:0042354)	7.88368710
11	negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)	7.72464693
12	vesicle fusion (GO:0006906)	7.65300463
13	peptidyl-lysine dimethylation (GO:0018027)	7.46934742
14	ribosomal small subunit assembly (GO:0000028)	7.43628984
15	coenzyme A biosynthetic process (GO:0015937)	7.32911721
16	autophagic vacuole fusion (GO:0000046)	6.86765337
17	macrophage chemotaxis (GO:0048246)	6.79111000
18	organ growth (GO:0035265)	6.60984275
19	localization within membrane (GO:0051668)	6.52364837
20	axis elongation (GO:0003401)	6.28760007
21	regulation of beta-amyloid formation (GO:1902003)	6.02237092
22	regulation of nitric-oxide synthase biosynthetic process (GO:0051769)	5.89345172
23	positive regulation of calcium ion import (GO:0090280)	5.88937881
24	regulation of T cell receptor signaling pathway (GO:0050856)	5.83486062
25	negative regulation of GTP catabolic process (GO:0033125)	5.80884343
26	negative regulation of GTPase activity (GO:0034260)	5.80884343
27	establishment of mitotic spindle orientation (GO:0000132)	5.79259506
28	protein import into peroxisome matrix (GO:0016558)	5.71216805
29	non-recombinational repair (GO:0000726)	5.47003080
30	double-strand break repair via nonhomologous end joining (GO:0006303)	5.47003080
31	monocyte chemotaxis (GO:0002548)	5.46981430
32	organelle membrane fusion (GO:0090174)	5.38103519
33	establishment of mitotic spindle localization (GO:0040001)	5.11843136
34	3-UTR-mediated mRNA stabilization (GO:0070935)	5.03144920
35	establishment of spindle orientation (GO:0051294)	5.02387772
36	acrosome assembly (GO:0001675)	4.95627922
37	negative regulation of circadian rhythm (GO:0042754)	4.95153149
38	regulation of amyloid precursor protein catabolic process (GO:1902991)	4.82447558
39	histone H3-K9 methylation (GO:0051567)	4.72404812
40	positive chemotaxis (GO:0050918)	4.65755371
41	detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)	4.65330801
42	pantothenate metabolic process (GO:0015939)	4.64410099
43	seminiferous tubule development (GO:0072520)	4.61059598
44	oxidative demethylation (GO:0070989)	4.59968140
45	purine nucleoside bisphosphate biosynthetic process (GO:0034033)	4.59080866
46	ribonucleoside bisphosphate biosynthetic process (GO:0034030)	4.59080866
47	nucleoside bisphosphate biosynthetic process (GO:0033866)	4.59080866
48	organelle fusion (GO:0048284)	4.58786427
49	regulation of stem cell maintenance (GO:2000036)	4.49642813
50	fucose metabolic process (GO:0006004)	4.46487955
51	positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)	4.38860509
52	regulation of autophagic vacuole assembly (GO:2000785)	4.32071569
53	coenzyme A metabolic process (GO:0015936)	4.28052708
54	protein targeting to lysosome (GO:0006622)	4.26107869
55	establishment of protein localization to vacuole (GO:0072666)	4.26107869
56	protein targeting to vacuole (GO:0006623)	4.26107869
57	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	4.18091020
58	fucosylation (GO:0036065)	4.13891160
59	regulation of antigen receptor-mediated signaling pathway (GO:0050854)	4.12404718
60	membrane budding (GO:0006900)	4.07679226
61	negative regulation of purine nucleotide catabolic process (GO:0033122)	4.01197293
62	regulation of fibroblast growth factor receptor signaling pathway (GO:0040036)	3.98877418
63	detection of chemical stimulus involved in sensory perception of taste (GO:0050912)	3.97754010
64	histone H3-K9 modification (GO:0061647)	3.89747403
65	regulation of cellular amide metabolic process (GO:0034248)	3.89485739
66	negative regulation of nucleotide catabolic process (GO:0030812)	3.84521281
67	protein targeting to peroxisome (GO:0006625)	3.81669089
68	establishment of protein localization to peroxisome (GO:0072663)	3.81669089
69	protein localization to peroxisome (GO:0072662)	3.81669089
70	single-organism membrane fusion (GO:0044801)	3.79043115
71	regulation of mammary gland epithelial cell proliferation (GO:0033599)	3.77905617
72	negative regulation of nucleoside metabolic process (GO:0045978)	3.69126407
73	establishment of spindle localization (GO:0051293)	3.67381762
74	Golgi transport vesicle coating (GO:0048200)	3.65312131
75	COPI coating of Golgi vesicle (GO:0048205)	3.65312131
76	regulation of peptidyl-threonine phosphorylation (GO:0010799)	3.63114460
77	regulation of vacuole organization (GO:0044088)	3.59755818
78	vesicle targeting (GO:0006903)	3.58053461
79	ER to Golgi vesicle-mediated transport (GO:0006888)	3.56929143
80	peroxisomal transport (GO:0043574)	3.54870527
81	regulation of calcium ion import (GO:0090279)	3.54220157
82	sodium-independent organic anion transport (GO:0043252)	3.49102725
83	negative regulation of dendrite morphogenesis (GO:0050774)	3.49055306
84	proteasome assembly (GO:0043248)	3.46890517
85	DNA integration (GO:0015074)	3.46806270
86	negative regulation of macroautophagy (GO:0016242)	3.41131587
87	imidazole-containing compound metabolic process (GO:0052803)	3.39810647
88	preassembly of GPI anchor in ER membrane (GO:0016254)	3.39582950
89	regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:2	3.34353598
90	telomere maintenance via recombination (GO:0000722)	3.30739786
91	RNA methylation (GO:0001510)	3.29090991
92	DNA demethylation (GO:0080111)	3.27604921
93	protein prenylation (GO:0018342)	12.8148464
94	prenylation (GO:0097354)	12.8148464
95	positive regulation of mitotic sister chromatid separation (GO:1901970)	12.3341382
96	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	12.3341382
97	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	12.3341382
98	negative regulation of Ras GTPase activity (GO:0034261)	12.1235618
99	eosinophil chemotaxis (GO:0048245)	10.6754408
100	negative regulation of T cell receptor signaling pathway (GO:0050860)	10.4933669

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	9.53265438
2	VDR_22108803_ChIP-Seq_LS180_Human	6.03370161
3	NOTCH1_21737748_ChIP-Seq_TLL_Human	4.56699220
4	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	4.48927926
5	AR_21572438_ChIP-Seq_LNCaP_Human	3.37759369
6	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.73336741
7	SRY_22984422_ChIP-ChIP_TESTIS_Rat	2.69610602
8	ZIC3_20872845_ChIP-ChIP_MESCs_Mouse	2.57097770
9	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.50680433
10	ZNF263_19887448_ChIP-Seq_K562_Human	2.47688756
11	YY1_21170310_ChIP-Seq_MESCs_Mouse	2.43896818
12	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.42945501
13	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	2.32097995
14	GATA1_22025678_ChIP-Seq_K562_Human	11.6173544
15	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.96780032
16	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.85643124
17	RXR_22108803_ChIP-Seq_LS180_Human	1.77080898
18	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.72912431
19	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.72912431
20	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.67342785
21	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.64849083
22	BCAT_22108803_ChIP-Seq_LS180_Human	1.64640110
23	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.63072053
24	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.56317390
25	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.56317390
26	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.56317390
27	TAF15_26573619_Chip-Seq_HEK293_Human	1.55439909
28	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.41949531
29	TP53_16413492_ChIP-PET_HCT116_Human	1.37311675
30	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.34799385
31	GATA3_26560356_Chip-Seq_TH1_Human	1.28556920
32	IRF1_19129219_ChIP-ChIP_H3396_Human	1.27184092
33	GBX2_23144817_ChIP-Seq_PC3_Human	1.26198726
34	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.25673891
35	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.23423276
36	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.18365391
37	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.14616731
38	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.12478544
39	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.11113939
40	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.10009554
41	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.01779646
42	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	1.00716425
43	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.00606623
44	GABP_17652178_ChIP-ChIP_JURKAT_Human	0.94016708
45	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.93058966
46	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.91646690
47	WDR5_24793694_ChIP-Seq_LNCAP_Human	0.91471339
48	ETS1_20019798_ChIP-Seq_JURKAT_Human	0.90759848
49	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.90050909
50	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.89714322
51	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	0.88893225
52	RUNX_20019798_ChIP-Seq_JUKART_Human	0.86719565
53	CTCF_21964334_Chip-Seq_Bcells_Human	0.85430443
54	CDX2_20551321_ChIP-Seq_CACO-2_Human	0.85315043
55	ZNF274_21170338_ChIP-Seq_K562_Hela	0.84193944
56	TBX3_20139965_ChIP-Seq_ESCs_Mouse	0.82496901
57	TBX3_20139965_ChIP-Seq_MESCs_Mouse	0.82363523
58	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.82362058
59	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.82090813
60	SOX3_22085726_ChIP-Seq_MUSCLE_Mouse	0.78297581
61	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	0.77123613
62	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.77094200
63	NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human	0.74647169
64	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.72381367
65	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	0.69017992
66	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.68548072
67	GATA1_19941826_ChIP-Seq_K562_Human	0.68233420
68	MYC_18555785_ChIP-Seq_MESCs_Mouse	0.67956385
69	TRIM28_19339689_ChIP-ChIP_MESCs_Mouse	0.67547902
70	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.66820233
71	TP53_22573176_ChIP-Seq_HFKS_Human	0.66302482
72	CTNNB1_20460455_ChIP-Seq_HCT116_Human	0.66276376
73	FUS_26573619_Chip-Seq_HEK293_Human	0.64467546
74	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.64288732
75	HTT_18923047_ChIP-ChIP_STHdh_Human	0.62864167
76	EOMES_20176728_ChIP-ChIP_TSCs_Mouse	0.61982171
77	TCF4_22108803_ChIP-Seq_LS180_Human	0.61804677
78	GATA3_21867929_ChIP-Seq_TH1_Mouse	0.60617385
79	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	0.60225259
80	RING1B_27294783_Chip-Seq_NPCs_Mouse	0.59338802
81	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.58893983
82	NR3C1_23031785_ChIP-Seq_PC12_Mouse	0.58340158
83	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.58238918
84	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.57617839
85	P300_19829295_ChIP-Seq_ESCs_Human	0.57161635
86	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.57148359
87	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.57114071
88	EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	0.56898852
89	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.55673686
90	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.54946547
91	STAT1_20625510_ChIP-Seq_HELA_Human	0.54857021
92	LUZP1_20508642_ChIP-Seq_ESCs_Mouse	0.54121099
93	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	0.53726633
94	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	0.53547180
95	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.52726782
96	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.52726782
97	SMC1_22415368_ChIP-Seq_MEFs_Mouse	0.52201186
98	ERG_20517297_ChIP-Seq_VCAP_Human	0.51118800
99	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.50954458
100	PU1_27457419_Chip-Seq_LIVER_Mouse	0.50495827

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006082_CNS_inflammation	5.63308581
2	MP0000467_abnormal_esophagus_morphology	3.30309915
3	MP0001664_abnormal_digestion	3.23215548
4	MP0001663_abnormal_digestive_system	3.21464533
5	MP0001919_abnormal_reproductive_system	2.68816700
6	MP0002751_abnormal_autonomic_nervous	2.58099426
7	MP0000383_abnormal_hair_follicle	2.56969642
8	MP0003115_abnormal_respiratory_system	2.47940572
9	MP0005381_digestive/alimentary_phenotyp	2.46852033
10	MP0000566_synostosis	13.0217211
11	MP0003303_peritoneal_inflammation	10.0522623
12	MP0002876_abnormal_thyroid_physiology	1.86469391
13	MP0005166_decreased_susceptibility_to	1.80850731
14	MP0010678_abnormal_skin_adnexa	1.77454213
15	MP0001915_intracranial_hemorrhage	1.72072341
16	MP0005389_reproductive_system_phenotype	1.59174206
17	MP0003937_abnormal_limbs/digits/tail_de	1.55716594
18	MP0000534_abnormal_ureter_morphology	1.55549584
19	MP0003453_abnormal_keratinocyte_physiol	1.51060910
20	MP0005076_abnormal_cell_differentiation	1.43573715
21	MP0005397_hematopoietic_system_phenotyp	1.40279205
22	MP0001545_abnormal_hematopoietic_system	1.40279205
23	MP0000428_abnormal_craniofacial_morphol	1.30203900
24	MP0005501_abnormal_skin_physiology	1.28508881
25	MP0000490_abnormal_crypts_of	1.15958289
26	MP0003763_abnormal_thymus_physiology	1.11039172
27	MP0001286_abnormal_eye_development	1.05961338
28	MP0000858_altered_metastatic_potential	1.05546576
29	MP0003329_amyloid_beta_deposits	1.02337264
30	MP0001293_anophthalmia	1.00765763
31	MP0002019_abnormal_tumor_incidence	0.93469898
32	MP0001764_abnormal_homeostasis	0.93319009
33	MP0010155_abnormal_intestine_physiology	0.83810190
34	MP0002109_abnormal_limb_morphology	0.81135572
35	MP0001963_abnormal_hearing_physiology	0.74939551
36	MP0000470_abnormal_stomach_morphology	0.74895413
37	MP0002115_abnormal_skeleton_extremities	0.74318777
38	MP0000358_abnormal_cell_content/	0.73011318
39	MP0003942_abnormal_urinary_system	0.72321047
40	MP0000477_abnormal_intestine_morphology	0.72320571
41	MP0000026_abnormal_inner_ear	0.71459450
42	MP0000604_amyloidosis	0.66918328
43	MP0009763_increased_sensitivity_to	0.65673046
44	MP0005197_abnormal_uvea_morphology	0.63925944
45	MP0009672_abnormal_birth_weight	0.62913511
46	MP0005508_abnormal_skeleton_morphology	0.61514565
47	MP0002405_respiratory_system_inflammati	0.59848230
48	MP0000432_abnormal_head_morphology	0.57725771
49	MP0002184_abnormal_innervation	0.56442296
50	MP0005023_abnormal_wound_healing	0.54763677
51	MP0005253_abnormal_eye_physiology	0.54427550
52	MP0008058_abnormal_DNA_repair	0.51561685
53	MP0002210_abnormal_sex_determination	0.48590894
54	MP0001175_abnormal_lung_morphology	0.47944589
55	MP0003935_abnormal_craniofacial_develop	0.47414084
56	MP0000681_abnormal_thyroid_gland	0.44520695
57	MP0000377_abnormal_hair_follicle	0.43865619
58	MP0002113_abnormal_skeleton_development	0.43665454
59	MP0001986_abnormal_taste_sensitivity	0.40435734
60	MP0003448_altered_tumor_morphology	0.39307173
61	MP0000627_abnormal_mammary_gland	0.38840956
62	MP0003638_abnormal_response/metabolism_	0.37980996
63	MP0005423_abnormal_somatic_nervous	0.37174434
64	MP0000372_irregular_coat_pigmentation	0.35437918
65	MP0005391_vision/eye_phenotype	0.35297199
66	MP0002735_abnormal_chemical_nociception	0.34648200
67	MP0010771_integument_phenotype	0.33362010
68	MP0003880_abnormal_central_pattern	0.33029022
69	MP0000163_abnormal_cartilage_morphology	0.32921506
70	MP0005025_abnormal_response_to	0.31474414
71	MP0003936_abnormal_reproductive_system	0.31374438
72	MP0002736_abnormal_nociception_after	0.30830207
73	MP0002752_abnormal_somatic_nervous	0.29571094
74	MP0002136_abnormal_kidney_physiology	0.29383301
75	MP0002822_catalepsy	0.29018051
76	MP0008875_abnormal_xenobiotic_pharmacok	0.28248722
77	MP0001348_abnormal_lacrimal_gland	0.26719292
78	MP0000350_abnormal_cell_proliferation	0.26338219
79	MP0002697_abnormal_eye_size	0.26164101
80	MP0002837_dystrophic_cardiac_calcinosis	0.25860438
81	MP0008004_abnormal_stomach_pH	0.24156132
82	MP0005332_abnormal_amino_acid	0.23505926
83	MP0002452_abnormal_antigen_presenting	0.22703832
84	MP0003195_calcinosis	0.21604135
85	MP0001968_abnormal_touch/_nociception	0.19998643
86	MP0005390_skeleton_phenotype	0.19470891
87	MP0008872_abnormal_physiological_respon	0.19409216
88	MP0002168_other_aberrant_phenotype	0.18699368
89	MP0004197_abnormal_fetal_growth/weight/	0.18442207
90	MP0002277_abnormal_respiratory_mucosa	0.17821334
91	MP0005000_abnormal_immune_tolerance	0.17138844
92	MP0006276_abnormal_autonomic_nervous	0.16088774
93	MP0001800_abnormal_humoral_immune	0.15375136
94	MP0005645_abnormal_hypothalamus_physiol	0.15125598
95	MP0005171_absent_coat_pigmentation	0.14906069
96	MP0000955_abnormal_spinal_cord	0.13629809
97	MP0009931_abnormal_skin_appearance	0.13496195
98	MP0002102_abnormal_ear_morphology	0.13070202
99	MP0010386_abnormal_urinary_bladder	0.12625679
100	MP0002081_perinatal_lethality	0.12332910

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Duplicated collecting system (HP:0000081)	9.09045262
2	Long foot (HP:0001833)	8.85947370
3	Abnormality of the renal collecting system (HP:0004742)	8.12607168
4	Large for gestational age (HP:0001520)	7.37659057
5	Acute lymphatic leukemia (HP:0006721)	6.94113491
6	Progressive muscle weakness (HP:0003323)	6.79942922
7	Hypoplastic pelvis (HP:0008839)	6.75976879
8	Adactyly (HP:0009776)	6.69215941
9	Abnormality of fatty-acid metabolism (HP:0004359)	6.25681703
10	Dry hair (HP:0011359)	6.16872840
11	Autoamputation (HP:0001218)	5.70124107
12	Menstrual irregularities (HP:0000858)	5.56383072
13	Pulmonary artery stenosis (HP:0004415)	5.49310571
14	Ureteral stenosis (HP:0000071)	5.45039082
15	Brushfield spots (HP:0001088)	5.28352565
16	Steatorrhea (HP:0002570)	5.15593757
17	Ureteral duplication (HP:0000073)	5.03896902
18	Ureteral obstruction (HP:0006000)	5.03342284
19	Abnormal auditory evoked potentials (HP:0006958)	4.90366117
20	Reduced subcutaneous adipose tissue (HP:0003758)	4.81255188
21	Hypoplastic nipples (HP:0002557)	4.79683054
22	Sudden death (HP:0001699)	4.38427629
23	Decreased lacrimation (HP:0000633)	4.20950752
24	Abnormal ventriculo-arterial connection (HP:0011563)	4.19952049
25	Transposition of the great arteries (HP:0001669)	4.19952049
26	Abnormal connection of the cardiac segments (HP:0011545)	4.19952049
27	Anhidrosis (HP:0000970)	4.17707123
28	Severe muscular hypotonia (HP:0006829)	4.08332736
29	Fat malabsorption (HP:0002630)	3.98714214
30	Broad-based gait (HP:0002136)	3.89802989
31	Increased number of teeth (HP:0011069)	3.86359616
32	Palmoplantar hyperkeratosis (HP:0000972)	3.69625804
33	Abnormality of vision evoked potentials (HP:0000649)	3.51883349
34	Palmar hyperkeratosis (HP:0010765)	3.48731055
35	Polyneuropathy (HP:0001271)	3.42459889
36	Generalized amyotrophy (HP:0003700)	3.35184236
37	Wide intermamillary distance (HP:0006610)	3.29648475
38	Decreased muscle mass (HP:0003199)	3.21005769
39	Polymicrogyria (HP:0002126)	3.14414051
40	Broad nasal tip (HP:0000455)	3.11504483
41	Large hands (HP:0001176)	3.07038062
42	Myoglobinuria (HP:0002913)	3.04356565
43	Plantar hyperkeratosis (HP:0007556)	2.96949436
44	Rhabdomyolysis (HP:0003201)	2.89735438
45	Epiphyseal stippling (HP:0010655)	2.77957506
46	Clubbing of toes (HP:0100760)	2.73570338
47	Flat face (HP:0012368)	2.66759103
48	Hypoplastic iliac wings (HP:0002866)	2.55974267
49	Steppage gait (HP:0003376)	2.54642527
50	Chorioretinal coloboma (HP:0000567)	2.52460292
51	Thickened calvaria (HP:0002684)	2.51727163
52	Basal ganglia calcification (HP:0002135)	2.45468470
53	Overfolded helix (HP:0000396)	2.44658997
54	Widely spaced teeth (HP:0000687)	2.42734509
55	Posterior embryotoxon (HP:0000627)	2.31922280
56	Purpura (HP:0000979)	2.28727162
57	Abnormality of the line of Schwalbe (HP:0008048)	2.24748684
58	Anxiety (HP:0000739)	2.21294774
59	Abnormally folded helix (HP:0008544)	2.19336040
60	Female pseudohermaphroditism (HP:0010458)	2.14812310
61	Foot dorsiflexor weakness (HP:0009027)	2.13211981
62	Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)	2.10532451
63	Aplasia/Hypoplasia of the nipples (HP:0006709)	2.08343189
64	Hammertoe (HP:0001765)	2.05607990
65	Absent toe (HP:0010760)	2.04921756
66	External ear malformation (HP:0008572)	2.00567786
67	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	12.3710866
68	Abnormality of the foot musculature (HP:0001436)	1.99969224
69	Thickened nuchal skin fold (HP:0000474)	1.97703222
70	Abnormal epiphyseal ossification (HP:0010656)	1.94186430
71	Primary adrenal insufficiency (HP:0008207)	1.91748506
72	Generalized muscle weakness (HP:0003324)	1.86114068
73	Prenatal maternal abnormality (HP:0002686)	1.85339676
74	Spastic tetraplegia (HP:0002510)	1.84749363
75	Arterial thrombosis (HP:0004420)	1.84058197
76	Abnormality of the epiphyses of the hand (HP:0005924)	1.80345237
77	Arthrogryposis multiplex congenita (HP:0002804)	1.78890454
78	Congenital onset (HP:0003577)	1.77983811
79	Gangrene (HP:0100758)	1.77298474
80	Stereotypic behavior (HP:0000733)	1.75485023
81	Decreased motor nerve conduction velocity (HP:0003431)	1.74427841
82	Abnormality involving the epiphyses of the upper limbs (HP:0003839)	1.70811952
83	Underdeveloped supraorbital ridges (HP:0009891)	1.63144781
84	Brachycephaly (HP:0000248)	1.62398294
85	Lactic acidosis (HP:0003128)	1.62130598
86	Aplasia/Hypoplasia involving the pelvis (HP:0009103)	1.61121673
87	Decreased number of peripheral myelinated nerve fibers (HP:0003380)	1.60881879
88	Nail dystrophy (HP:0008404)	1.50665882
89	Short philtrum (HP:0000322)	1.49599516
90	Depressed nasal ridge (HP:0000457)	1.49227047
91	Respiratory insufficiency due to muscle weakness (HP:0002747)	1.45556643
92	Scrotal hypoplasia (HP:0000046)	1.43492131
93	Hypoplastic ilia (HP:0000946)	1.42485541
94	Freckling (HP:0001480)	1.41834754
95	Abnormality of primary teeth (HP:0006481)	1.41343748
96	Opacification of the corneal stroma (HP:0007759)	1.37543271
97	Postnatal microcephaly (HP:0005484)	1.35663269
98	Pulmonary embolism (HP:0002204)	1.34656416
99	Webbed neck (HP:0000465)	1.33824115
100	Postnatal growth retardation (HP:0008897)	1.30454185

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MKNK1	6.85109761
2	TAOK2	5.56530483
3	TAOK1	5.44741180
4	MAP3K3	4.09810620
5	MAP2K3	3.98805805
6	MAP3K11	3.94475039
7	JAK3	2.49452113
8	MKNK2	11.5896544
9	ABL2	1.88737701
10	DYRK1A	1.75338755
11	MAP3K5	1.35041530
12	SRPK1	1.08538419
13	MAP3K1	1.00445558
14	CHEK2	0.79489290
15	MAP3K8	0.66603360
16	PRKCQ	0.48135253
17	TIE1	0.33602255
18	CSNK1A1	0.20328366
19	ABL1	0.14876973
20	GRK1	0.14776398
21	IGF1R	0.14441722
22	OBSCN	0.12033544
23	INSRR	0.10832882
24	PRKCD	0.08694875
25	ADRBK2	0.08593077
26	WNK3	0.08370396
27	TXK	0.08233251
28	MUSK	0.07708070
29	CSNK2A2	0.06114216
30	GRK7	0.06048564
31	MAP4K2	0.04321444
32	CSNK2A1	0.03365317
33	TSSK6	0.03365146
34	TEC	0.02725823
35	CSNK1E	0.02519980
36	PRKCA	0.01035530
37	PIK3CG	0.01011672
38	WNK4	0.00694821
39	CCNB1	0.00220145
40	LYN	-0.1152530
41	MOS	-0.1139948
42	MAPK14	-0.1129689
43	SYK	-0.1105942
44	BCKDK	-0.1098923
45	FES	-0.1098562
46	TNK2	-0.1089456
47	CAMK2D	-0.1046254
48	TTN	-0.1041715
49	CDK2	-0.1023617
50	PRKG2	-0.1021015
51	PLK3	-0.1019958
52	MARK1	-0.0999269
53	MST1R	-0.0999134
54	CAMK2B	-0.0949588
55	PLK2	-0.0945749
56	EPHA2	-0.0922001
57	IKBKE	-0.0890976
58	PRKG1	-0.0873672
59	PINK1	-0.0868850
60	BMPR1B	-0.0860336
61	PIM2	-0.0843531
62	TGFBR1	-0.0827647
63	BTK	-0.0825652
64	GRK6	-0.0820760
65	DDR2	-0.0819986
66	VRK1	-0.0819856
67	ZAK	-0.0797691
68	PBK	-0.0760623
69	CAMK2G	-0.0759455
70	PRKCE	-0.0752281
71	NTRK2	-0.0728436
72	MYLK	-0.0704323
73	CAMK2A	-0.0694195
74	KDR	-0.0684643
75	ADRBK1	-0.0678583
76	TRIM28	-0.0610957
77	PLK4	-0.0574448
78	LMTK2	-0.0545808
79	PRKCG	-0.0529409
80	FRK	-0.0518473
81	MAP2K6	-0.0506898
82	STK39	-0.0491686
83	MATK	-0.0467800
84	TGFBR2	-0.0452259
85	PIK3CA	-0.0418964
86	OXSR1	-0.0396628
87	ITK	-0.0304589
88	AURKA	-0.0298458
89	PRKACA	-0.0289509
90	SRC	-0.0279722
91	GRK5	-0.0239693
92	AKT3	-0.0211235
93	TLK1	-0.0189010
94	KIT	-0.0171612
95	PHKG2	-0.0160581
96	PHKG1	-0.0160581
97	MAPK15	-0.0135735
98	EPHA4	-0.0118536
99	ERBB4	-0.0044767
100	PRKCB	-0.0032212

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	8.47899148
2	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	7.11397739
3	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.34440193
4	RNA polymerase_Homo sapiens_hsa03020	3.24098454
5	Taste transduction_Homo sapiens_hsa04742	3.02057589
6	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	3.01726727
7	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.94918163
8	Fatty acid elongation_Homo sapiens_hsa00062	2.81792383
9	Lysine degradation_Homo sapiens_hsa00310	2.48580855
10	Butanoate metabolism_Homo sapiens_hsa00650	2.36794542
11	Proteasome_Homo sapiens_hsa03050	2.00738877
12	beta-Alanine metabolism_Homo sapiens_hsa00410	2.00577433
13	One carbon pool by folate_Homo sapiens_hsa00670	1.95749241
14	Glycerolipid metabolism_Homo sapiens_hsa00561	1.80311897
15	Amoebiasis_Homo sapiens_hsa05146	1.75280922
16	Tryptophan metabolism_Homo sapiens_hsa00380	1.75025471
17	Propanoate metabolism_Homo sapiens_hsa00640	1.69519514
18	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.42319658
19	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	1.17954945
20	Fatty acid degradation_Homo sapiens_hsa00071	1.12667018
21	Viral myocarditis_Homo sapiens_hsa05416	1.11300264
22	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.93430398
23	Peroxisome_Homo sapiens_hsa04146	0.91574648
24	Complement and coagulation cascades_Homo sapiens_hsa04610	0.90042151
25	Fatty acid metabolism_Homo sapiens_hsa01212	0.89851934
26	Asthma_Homo sapiens_hsa05310	0.76967736
27	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.75256203
28	Nicotine addiction_Homo sapiens_hsa05033	0.69820856
29	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.68877354
30	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.68483160
31	Allograft rejection_Homo sapiens_hsa05330	0.67729440
32	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.65157168
33	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.63192388
34	Caffeine metabolism_Homo sapiens_hsa00232	0.61302864
35	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.61076475
36	AMPK signaling pathway_Homo sapiens_hsa04152	0.58963039
37	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.58700010
38	Retinol metabolism_Homo sapiens_hsa00830	0.54616532
39	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.53829941
40	Olfactory transduction_Homo sapiens_hsa04740	0.53038696
41	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.52632916
42	Pyrimidine metabolism_Homo sapiens_hsa00240	0.52395477
43	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.51666642
44	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.51308932
45	MicroRNAs in cancer_Homo sapiens_hsa05206	0.47950556
46	Linoleic acid metabolism_Homo sapiens_hsa00591	0.47730412
47	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.47374132
48	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.47016942
49	Cholinergic synapse_Homo sapiens_hsa04725	0.46877428
50	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.46156519
51	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.45707295
52	Nucleotide excision repair_Homo sapiens_hsa03420	0.44610572
53	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.44128144
54	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.40753512
55	Salmonella infection_Homo sapiens_hsa05132	0.39246640
56	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.37254227
57	Graft-versus-host disease_Homo sapiens_hsa05332	0.36893277
58	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.36125934
59	TNF signaling pathway_Homo sapiens_hsa04668	0.35803664
60	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.35478150
61	Toxoplasmosis_Homo sapiens_hsa05145	0.35268979
62	RNA transport_Homo sapiens_hsa03013	0.35110376
63	GnRH signaling pathway_Homo sapiens_hsa04912	0.33911815
64	Fat digestion and absorption_Homo sapiens_hsa04975	0.33890998
65	Phototransduction_Homo sapiens_hsa04744	0.33272628
66	Chemical carcinogenesis_Homo sapiens_hsa05204	0.32925557
67	Choline metabolism in cancer_Homo sapiens_hsa05231	0.32710963
68	Tyrosine metabolism_Homo sapiens_hsa00350	0.30718206
69	Type I diabetes mellitus_Homo sapiens_hsa04940	0.30712649
70	Purine metabolism_Homo sapiens_hsa00230	0.29846519
71	Protein digestion and absorption_Homo sapiens_hsa04974	0.27268719
72	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.26951954
73	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.26825716
74	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.26673931
75	Nitrogen metabolism_Homo sapiens_hsa00910	0.24560365
76	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.24263426
77	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.22916426
78	Malaria_Homo sapiens_hsa05144	0.20171956
79	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.18626883
80	Phagosome_Homo sapiens_hsa04145	0.16693380
81	Salivary secretion_Homo sapiens_hsa04970	0.15706131
82	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.15668069
83	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.15425656
84	Bile secretion_Homo sapiens_hsa04976	0.14851550
85	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.13610423
86	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.13011300
87	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.12974259
88	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.12785463
89	ECM-receptor interaction_Homo sapiens_hsa04512	0.12543407
90	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.12325475
91	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.10771251
92	Primary immunodeficiency_Homo sapiens_hsa05340	0.10439329
93	Metabolic pathways_Homo sapiens_hsa01100	0.10075512
94	Rheumatoid arthritis_Homo sapiens_hsa05323	0.09979487
95	Carbon metabolism_Homo sapiens_hsa01200	0.09957275
96	Phenylalanine metabolism_Homo sapiens_hsa00360	0.08183064
97	African trypanosomiasis_Homo sapiens_hsa05143	0.08125686
98	Pancreatic secretion_Homo sapiens_hsa04972	0.07742806
99	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.06169353
100	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.06057406

GAPDHP15

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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