ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of mitotic sister chromatid separation (GO:1901970)	8.97396741
2	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	8.97396741
3	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	8.97396741
4	negative regulation of Ras GTPase activity (GO:0034261)	8.83130258
5	ribosomal small subunit assembly (GO:0000028)	8.11794934
6	eosinophil chemotaxis (GO:0048245)	7.89545752
7	negative regulation of T cell receptor signaling pathway (GO:0050860)	7.87785869
8	fucose catabolic process (GO:0019317)	7.36244195
9	L-fucose metabolic process (GO:0042354)	7.36244195
10	L-fucose catabolic process (GO:0042355)	7.36244195
11	eosinophil migration (GO:0072677)	7.14240353
12	negative regulation of peptidyl-threonine phosphorylation (GO:0010801)	6.73826673
13	regulation of sister chromatid cohesion (GO:0007063)	6.67042989
14	regulation of mononuclear cell migration (GO:0071675)	6.55882901
15	negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)	6.18246626
16	positive regulation of chromosome segregation (GO:0051984)	5.97916352
17	branch elongation of an epithelium (GO:0060602)	5.97777002
18	vesicle fusion (GO:0006906)	5.75067024
19	coenzyme A biosynthetic process (GO:0015937)	5.70091018
20	negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)	5.63901949
21	autophagic vacuole fusion (GO:0000046)	5.50381553
22	macrophage chemotaxis (GO:0048246)	4.93922769
23	regulation of T cell receptor signaling pathway (GO:0050856)	4.90981339
24	positive regulation of calcium ion import (GO:0090280)	4.70862424
25	organelle membrane fusion (GO:0090174)	4.51932995
26	proteasome assembly (GO:0043248)	4.50811847
27	non-recombinational repair (GO:0000726)	4.48071892
28	double-strand break repair via nonhomologous end joining (GO:0006303)	4.48071892
29	organ growth (GO:0035265)	4.46574573
30	detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)	4.39633300
31	protein import into peroxisome matrix (GO:0016558)	4.34722060
32	oxidative demethylation (GO:0070989)	4.31174560
33	localization within membrane (GO:0051668)	4.23252587
34	monocyte chemotaxis (GO:0002548)	4.21648870
35	regulation of nitric-oxide synthase biosynthetic process (GO:0051769)	4.20581707
36	peptidyl-lysine dimethylation (GO:0018027)	4.07310852
37	axis elongation (GO:0003401)	3.95799404
38	fucosylation (GO:0036065)	3.84779363
39	regulation of beta-amyloid formation (GO:1902003)	3.82598119
40	chaperone-mediated protein transport (GO:0072321)	3.80749572
41	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.80396276
42	ATP synthesis coupled proton transport (GO:0015986)	3.80396276
43	establishment of mitotic spindle orientation (GO:0000132)	3.78811074
44	detection of chemical stimulus involved in sensory perception of taste (GO:0050912)	3.78665264
45	DNA deamination (GO:0045006)	3.78356056
46	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.77488593
47	preassembly of GPI anchor in ER membrane (GO:0016254)	3.77433527
48	folic acid-containing compound biosynthetic process (GO:0009396)	3.73507927
49	acrosome assembly (GO:0001675)	3.68696094
50	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	3.67402618
51	negative regulation of GTPase activity (GO:0034260)	3.65423352
52	negative regulation of GTP catabolic process (GO:0033125)	3.65423352
53	fucose metabolic process (GO:0006004)	3.64908456
54	seminiferous tubule development (GO:0072520)	3.62910881
55	pantothenate metabolic process (GO:0015939)	3.61689930
56	organelle fusion (GO:0048284)	3.52172908
57	protein neddylation (GO:0045116)	3.46212592
58	regulation of antigen receptor-mediated signaling pathway (GO:0050854)	3.45634908
59	metallo-sulfur cluster assembly (GO:0031163)	3.40502247
60	iron-sulfur cluster assembly (GO:0016226)	3.40502247
61	establishment of mitotic spindle localization (GO:0040001)	3.37829362
62	purine nucleoside bisphosphate biosynthetic process (GO:0034033)	3.28555496
63	ribonucleoside bisphosphate biosynthetic process (GO:0034030)	3.28555496
64	nucleoside bisphosphate biosynthetic process (GO:0033866)	3.28555496
65	DNA demethylation (GO:0080111)	3.26520410
66	intracellular protein transmembrane import (GO:0044743)	3.20582473
67	regulation of autophagic vacuole assembly (GO:2000785)	3.19254029
68	negative regulation of circadian rhythm (GO:0042754)	3.14810425
69	positive chemotaxis (GO:0050918)	3.14089575
70	coenzyme A metabolic process (GO:0015936)	3.13146056
71	positive regulation of interleukin-1 beta secretion (GO:0050718)	3.08404240
72	single-organism membrane fusion (GO:0044801)	3.06323107
73	DNA integration (GO:0015074)	3.05378867
74	establishment of spindle orientation (GO:0051294)	3.03992146
75	ER to Golgi vesicle-mediated transport (GO:0006888)	3.01580213
76	sodium-independent organic anion transport (GO:0043252)	3.00204593
77	telomere maintenance via recombination (GO:0000722)	2.99412321
78	positive regulation of interleukin-1 secretion (GO:0050716)	2.95393813
79	regulation of fibroblast growth factor receptor signaling pathway (GO:0040036)	2.90100401
80	tRNA modification (GO:0006400)	2.84591794
81	mitochondrial RNA metabolic process (GO:0000959)	2.84311395
82	regulation of amyloid precursor protein catabolic process (GO:1902991)	2.83441501
83	protein targeting to peroxisome (GO:0006625)	2.82813668
84	establishment of protein localization to peroxisome (GO:0072663)	2.82813668
85	protein localization to peroxisome (GO:0072662)	2.82813668
86	regulation of interleukin-1 beta secretion (GO:0050706)	2.82025433
87	regulation of isotype switching to IgG isotypes (GO:0048302)	2.80753094
88	RNA methylation (GO:0001510)	2.79871580
89	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.76427544
90	termination of RNA polymerase III transcription (GO:0006386)	2.76427544
91	regulation of cellular amino acid metabolic process (GO:0006521)	2.76133237
92	negative regulation of macroautophagy (GO:0016242)	2.75510084
93	histone H3-K9 methylation (GO:0051567)	2.71438286
94	GPI anchor metabolic process (GO:0006505)	2.69801918
95	GPI anchor biosynthetic process (GO:0006506)	2.69672139
96	regulation of T cell apoptotic process (GO:0070232)	2.69270491
97	regulation of stem cell maintenance (GO:2000036)	2.68491127
98	imidazole-containing compound metabolic process (GO:0052803)	2.68035653
99	prenylation (GO:0097354)	10.2744482
100	protein prenylation (GO:0018342)	10.2744482

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	7.61885768
2	GATA1_22025678_ChIP-Seq_K562_Human	6.56958468
3	VDR_22108803_ChIP-Seq_LS180_Human	5.63700791
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.24741115
5	NOTCH1_21737748_ChIP-Seq_TLL_Human	3.86261236
6	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.53203725
7	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.31486373
8	FLI1_27457419_Chip-Seq_LIVER_Mouse	3.06182428
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.78774134
10	YY1_21170310_ChIP-Seq_MESCs_Mouse	2.51060819
11	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.48433308
12	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.32069915
13	AR_21572438_ChIP-Seq_LNCaP_Human	2.31589396
14	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.29559700
15	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.27655519
16	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.18025385
17	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.17956835
18	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.15980559
19	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.05402495
20	ZNF274_21170338_ChIP-Seq_K562_Hela	1.97178802
21	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.96424363
22	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.91696458
23	VDR_23849224_ChIP-Seq_CD4+_Human	1.86963375
24	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.85504036
25	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.80384881
26	IRF1_19129219_ChIP-ChIP_H3396_Human	1.74488090
27	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.64924397
28	ZNF263_19887448_ChIP-Seq_K562_Human	1.61510389
29	BCAT_22108803_ChIP-Seq_LS180_Human	1.54622635
30	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.50879831
31	TP53_22573176_ChIP-Seq_HFKS_Human	1.50646264
32	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.39609622
33	ELK1_19687146_ChIP-ChIP_HELA_Human	1.38927984
34	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.35687285
35	GATA3_26560356_Chip-Seq_TH1_Human	1.28326081
36	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.26940625
37	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.26272219
38	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.23414385
39	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.22450108
40	FOXP3_21729870_ChIP-Seq_TREG_Human	1.21049760
41	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.20412120
42	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.20412120
43	RXR_22108803_ChIP-Seq_LS180_Human	1.18272400
44	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.14432818
45	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.14040956
46	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.11385315
47	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.11385315
48	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.10770193
49	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.09922982
50	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.09471542
51	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.06871614
52	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.06212513
53	NANOG_19829295_ChIP-Seq_ESCs_Human	1.06050742
54	SOX2_19829295_ChIP-Seq_ESCs_Human	1.06050742
55	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.02560553
56	ZIC3_20872845_ChIP-ChIP_MESCs_Mouse	1.02342883
57	TAF15_26573619_Chip-Seq_HEK293_Human	1.00540652
58	ERG_20517297_ChIP-Seq_VCAP_Human	0.99519926
59	FUS_26573619_Chip-Seq_HEK293_Human	0.98673219
60	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.97674327
61	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.96567175
62	P300_19829295_ChIP-Seq_ESCs_Human	0.96543185
63	NANOG_20526341_ChIP-Seq_ESCs_Human	0.94501741
64	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	0.92355751
65	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.92094283
66	TCF4_22108803_ChIP-Seq_LS180_Human	0.92064315
67	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.92026688
68	AR_20517297_ChIP-Seq_VCAP_Human	0.91843641
69	GABP_19822575_ChIP-Seq_HepG2_Human	0.89342535
70	NCOR_22424771_ChIP-Seq_293T_Human	0.87894884
71	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.87386399
72	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.86217284
73	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	0.85692140
74	CREB1_15753290_ChIP-ChIP_HEK293T_Human	0.84503745
75	EZH2_22144423_ChIP-Seq_EOC_Human	0.82232619
76	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.82034184
77	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.81234292
78	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.81111177
79	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.80989212
80	GBX2_23144817_ChIP-Seq_PC3_Human	0.80180496
81	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.78260779
82	OCT4_20526341_ChIP-Seq_ESCs_Human	0.77991168
83	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.76866399
84	DCP1A_22483619_ChIP-Seq_HELA_Human	0.75947870
85	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.75867163
86	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.75451372
87	CBP_20019798_ChIP-Seq_JUKART_Human	0.75451372
88	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.74833063
89	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.74430815
90	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.73745166
91	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.72362974
92	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.72124749
93	RUNX_20019798_ChIP-Seq_JUKART_Human	0.71473252
94	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.70893078
95	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.70555361
96	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.70123031
97	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.69876536
98	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.69804210
99	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.69355850
100	TTF2_22483619_ChIP-Seq_HELA_Human	0.69142068

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000566_synostosis	9.95748181
2	MP0003303_peritoneal_inflammation	7.08867132
3	MP0006082_CNS_inflammation	4.37256878
4	MP0001919_abnormal_reproductive_system	3.04036795
5	MP0001663_abnormal_digestive_system	2.89070923
6	MP0001664_abnormal_digestion	2.57952521
7	MP0002751_abnormal_autonomic_nervous	2.31647531
8	MP0005381_digestive/alimentary_phenotyp	2.27255816
9	MP0005389_reproductive_system_phenotype	2.15226346
10	MP0000383_abnormal_hair_follicle	2.05132598
11	MP0002876_abnormal_thyroid_physiology	1.94876618
12	MP0003011_delayed_dark_adaptation	1.92349439
13	MP0000467_abnormal_esophagus_morphology	1.81375333
14	MP0003195_calcinosis	1.61102569
15	MP0001293_anophthalmia	1.60318084
16	MP0005671_abnormal_response_to	1.54308769
17	MP0008872_abnormal_physiological_respon	1.53969533
18	MP0003115_abnormal_respiratory_system	1.52663454
19	MP0008875_abnormal_xenobiotic_pharmacok	1.49533235
20	MP0003763_abnormal_thymus_physiology	1.46309057
21	MP0000372_irregular_coat_pigmentation	1.45491111
22	MP0002102_abnormal_ear_morphology	1.43339585
23	MP0005166_decreased_susceptibility_to	1.30162577
24	MP0006292_abnormal_olfactory_placode	1.26469707
25	MP0000534_abnormal_ureter_morphology	1.24765852
26	MP0002837_dystrophic_cardiac_calcinosis	1.23006325
27	MP0003937_abnormal_limbs/digits/tail_de	1.20760038
28	MP0002138_abnormal_hepatobiliary_system	1.18950991
29	MP0004147_increased_porphyrin_level	1.16191980
30	MP0004142_abnormal_muscle_tone	1.13282065
31	MP0000490_abnormal_crypts_of	1.12321335
32	MP0005551_abnormal_eye_electrophysiolog	1.11671737
33	MP0006276_abnormal_autonomic_nervous	1.11396333
34	MP0001986_abnormal_taste_sensitivity	1.10287970
35	MP0001968_abnormal_touch/_nociception	1.09243358
36	MP0005253_abnormal_eye_physiology	1.09082904
37	MP0001873_stomach_inflammation	1.05115328
38	MP0010678_abnormal_skin_adnexa	1.04803344
39	MP0002736_abnormal_nociception_after	1.01348768
40	MP0001764_abnormal_homeostasis	1.01287869
41	MP0004782_abnormal_surfactant_physiolog	1.00423578
42	MP0001286_abnormal_eye_development	0.98253381
43	MP0002653_abnormal_ependyma_morphology	0.95413339
44	MP0008058_abnormal_DNA_repair	0.95340345
45	MP0005084_abnormal_gallbladder_morpholo	0.94328518
46	MP0002277_abnormal_respiratory_mucosa	0.92904860
47	MP0003646_muscle_fatigue	0.89641946
48	MP0003283_abnormal_digestive_organ	0.89594670
49	MP0004145_abnormal_muscle_electrophysio	0.88239717
50	MP0002163_abnormal_gland_morphology	0.88093902
51	MP0001800_abnormal_humoral_immune	0.87611944
52	MP0005645_abnormal_hypothalamus_physiol	0.87156048
53	MP0010155_abnormal_intestine_physiology	0.86933539
54	MP0008877_abnormal_DNA_methylation	0.86932655
55	MP0000026_abnormal_inner_ear	0.86274248
56	MP0001440_abnormal_grooming_behavior	0.85230067
57	MP0001835_abnormal_antigen_presentation	0.84471972
58	MP0001963_abnormal_hearing_physiology	0.82743246
59	MP0002210_abnormal_sex_determination	0.81825923
60	MP0002405_respiratory_system_inflammati	0.79178551
61	MP0006072_abnormal_retinal_apoptosis	0.78718682
62	MP0005387_immune_system_phenotype	0.78401260
63	MP0001790_abnormal_immune_system	0.78401260
64	MP0001915_intracranial_hemorrhage	0.77131580
65	MP0001529_abnormal_vocalization	0.75362034
66	MP0003806_abnormal_nucleotide_metabolis	0.75359000
67	MP0002019_abnormal_tumor_incidence	0.74461151
68	MP0001485_abnormal_pinna_reflex	0.73995224
69	MP0001984_abnormal_olfaction	0.73329886
70	MP0009764_decreased_sensitivity_to	0.73304997
71	MP0004885_abnormal_endolymph	0.73053466
72	MP0009785_altered_susceptibility_to	0.72755002
73	MP0000358_abnormal_cell_content/	0.70303146
74	MP0009745_abnormal_behavioral_response	0.67219583
75	MP0000685_abnormal_immune_system	0.65688657
76	MP0005000_abnormal_immune_tolerance	0.65103123
77	MP0003638_abnormal_response/metabolism_	0.64653994
78	MP0005332_abnormal_amino_acid	0.64287280
79	MP0003936_abnormal_reproductive_system	0.64027217
80	MP0000470_abnormal_stomach_morphology	0.63881910
81	MP0001905_abnormal_dopamine_level	0.63734906
82	MP0002184_abnormal_innervation	0.63549110
83	MP0004742_abnormal_vestibular_system	0.62134207
84	MP0002234_abnormal_pharynx_morphology	0.62119627
85	MP0005025_abnormal_response_to	0.61977101
86	MP0005501_abnormal_skin_physiology	0.61425165
87	MP0008789_abnormal_olfactory_epithelium	0.60425197
88	MP0002938_white_spotting	0.60235558
89	MP0002109_abnormal_limb_morphology	0.60198712
90	MP0002272_abnormal_nervous_system	0.59896364
91	MP0006036_abnormal_mitochondrial_physio	0.59233057
92	MP0002752_abnormal_somatic_nervous	0.58842920
93	MP0005085_abnormal_gallbladder_physiolo	0.58842507
94	MP0005499_abnormal_olfactory_system	0.56812751
95	MP0005394_taste/olfaction_phenotype	0.56812751
96	MP0009333_abnormal_splenocyte_physiolog	0.56769838
97	MP0005410_abnormal_fertilization	0.55601449
98	MP0002452_abnormal_antigen_presenting	0.55121494
99	MP0002638_abnormal_pupillary_reflex	0.54495942
100	MP0001970_abnormal_pain_threshold	0.54387115

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	7.54392732
2	Duplicated collecting system (HP:0000081)	7.09489239
3	Large for gestational age (HP:0001520)	6.50477165
4	Abnormality of the renal collecting system (HP:0004742)	6.48009055
5	Long foot (HP:0001833)	5.69352904
6	Adactyly (HP:0009776)	5.13962547
7	Acute lymphatic leukemia (HP:0006721)	4.28106259
8	Abnormality of fatty-acid metabolism (HP:0004359)	4.05958006
9	Dry hair (HP:0011359)	4.01045029
10	Hypoplastic pelvis (HP:0008839)	3.90483953
11	Progressive muscle weakness (HP:0003323)	3.65886408
12	Brushfield spots (HP:0001088)	3.63699876
13	Ureteral stenosis (HP:0000071)	3.62137920
14	Ureteral duplication (HP:0000073)	3.57822525
15	Ureteral obstruction (HP:0006000)	3.51399185
16	Steatorrhea (HP:0002570)	3.45985018
17	Hypoplastic nipples (HP:0002557)	3.42843258
18	Acute necrotizing encephalopathy (HP:0006965)	3.36374639
19	Increased hepatocellular lipid droplets (HP:0006565)	3.25743820
20	Pulmonary artery stenosis (HP:0004415)	3.24158513
21	Broad-based gait (HP:0002136)	3.21431237
22	Severe muscular hypotonia (HP:0006829)	3.19496531
23	Mitochondrial inheritance (HP:0001427)	3.09918426
24	Autoamputation (HP:0001218)	3.04107197
25	Menstrual irregularities (HP:0000858)	2.98486778
26	Lipid accumulation in hepatocytes (HP:0006561)	2.93306624
27	Lactic acidosis (HP:0003128)	2.86013788
28	Reduced subcutaneous adipose tissue (HP:0003758)	2.82561409
29	Increased CSF lactate (HP:0002490)	2.80707308
30	Acute encephalopathy (HP:0006846)	2.79586634
31	Abnormal mitochondria in muscle tissue (HP:0008316)	2.76615149
32	Wide intermamillary distance (HP:0006610)	2.74863068
33	Increased serum lactate (HP:0002151)	2.70502959
34	Abnormal auditory evoked potentials (HP:0006958)	2.69153181
35	Decreased muscle mass (HP:0003199)	2.68247151
36	Progressive macrocephaly (HP:0004481)	2.66662283
37	Clubbing of toes (HP:0100760)	2.61331346
38	Renal Fanconi syndrome (HP:0001994)	2.54554528
39	Anhidrosis (HP:0000970)	2.51663465
40	Fat malabsorption (HP:0002630)	2.51096317
41	Polyneuropathy (HP:0001271)	2.47323900
42	Chorioretinal coloboma (HP:0000567)	2.39934868
43	Sudden death (HP:0001699)	2.39179766
44	Hepatocellular necrosis (HP:0001404)	2.37818326
45	Congenital stationary night blindness (HP:0007642)	2.37723307
46	Increased number of teeth (HP:0011069)	2.35969936
47	3-Methylglutaconic aciduria (HP:0003535)	2.35314776
48	Exercise intolerance (HP:0003546)	2.28603528
49	Congenital, generalized hypertrichosis (HP:0004540)	2.28596117
50	Abnormality of midbrain morphology (HP:0002418)	2.23746791
51	Molar tooth sign on MRI (HP:0002419)	2.23746791
52	Polymicrogyria (HP:0002126)	2.23045627
53	Palmoplantar hyperkeratosis (HP:0000972)	2.16738648
54	Exertional dyspnea (HP:0002875)	2.14928282
55	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.13985897
56	Abnormality of the labia minora (HP:0012880)	2.11040171
57	Basal ganglia calcification (HP:0002135)	2.10822901
58	Hepatic necrosis (HP:0002605)	2.07045931
59	Respiratory failure (HP:0002878)	2.06967581
60	Widely spaced teeth (HP:0000687)	2.06257165
61	Transposition of the great arteries (HP:0001669)	2.06177857
62	Abnormal connection of the cardiac segments (HP:0011545)	2.06177857
63	Abnormal ventriculo-arterial connection (HP:0011563)	2.06177857
64	Palmar hyperkeratosis (HP:0010765)	1.98114992
65	Pancreatic cysts (HP:0001737)	1.97298661
66	Posterior embryotoxon (HP:0000627)	1.96576999
67	Optic disc pallor (HP:0000543)	1.95395307
68	Abnormality of the line of Schwalbe (HP:0008048)	1.93996081
69	Abnormality of vision evoked potentials (HP:0000649)	1.93016293
70	Epiphyseal stippling (HP:0010655)	1.92811682
71	Cerebral edema (HP:0002181)	1.90659612
72	Female pseudohermaphroditism (HP:0010458)	1.90136889
73	Anxiety (HP:0000739)	1.88744533
74	CNS demyelination (HP:0007305)	1.86953051
75	Rhabdomyolysis (HP:0003201)	1.84269850
76	True hermaphroditism (HP:0010459)	1.83639236
77	Spastic tetraplegia (HP:0002510)	1.82852754
78	Hypoplastic iliac wings (HP:0002866)	1.82746450
79	Aplasia/Hypoplasia of the nipples (HP:0006709)	1.82045379
80	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.78317212
81	Absent/shortened dynein arms (HP:0200106)	1.78317212
82	Decreased lacrimation (HP:0000633)	1.78007015
83	Increased intramyocellular lipid droplets (HP:0012240)	1.75314327
84	Oral leukoplakia (HP:0002745)	1.73194089
85	Gangrene (HP:0100758)	1.73125317
86	Flat face (HP:0012368)	1.72693106
87	Plantar hyperkeratosis (HP:0007556)	1.70125818
88	Depressed nasal ridge (HP:0000457)	1.69900655
89	Pancreatic fibrosis (HP:0100732)	1.69716882
90	IgG deficiency (HP:0004315)	1.67510968
91	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.66892542
92	Parakeratosis (HP:0001036)	1.65658094
93	Medial flaring of the eyebrow (HP:0010747)	1.65535669
94	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.65055879
95	Abolished electroretinogram (ERG) (HP:0000550)	1.64861057
96	Myoglobinuria (HP:0002913)	1.64099793
97	Abnormality of renal resorption (HP:0011038)	1.63417176
98	Hypoproteinemia (HP:0003075)	1.63000633
99	Hypomagnesemia (HP:0002917)	1.62701812
100	Pendular nystagmus (HP:0012043)	1.62533229

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MKNK1	6.34773638
2	TAOK2	4.70119233
3	TAOK1	4.52542271
4	MAP3K3	3.63476250
5	MAP3K11	3.55387837
6	MAP2K3	3.00226446
7	JAK3	2.07673665
8	MKNK2	10.7666971
9	ABL2	1.83778907
10	DYRK1A	1.70419153
11	SRPK1	1.70210079
12	VRK2	1.39498424
13	TLK1	1.31818482
14	MAP3K5	1.06376332
15	TIE1	1.04925349
16	WNK4	1.00156653
17	ZAK	0.94699178
18	ADRBK2	0.94606711
19	TSSK6	0.89792769
20	GRK1	0.87705035
21	TXK	0.83907304
22	CHEK2	0.79004548
23	MST4	0.73455569
24	NUAK1	0.73201032
25	MAP4K2	0.71235979
26	TRIM28	0.70678663
27	STK39	0.70647445
28	PRKCQ	0.70355762
29	VRK1	0.68304203
30	WNK3	0.61951847
31	TAF1	0.58102787
32	STK16	0.53702270
33	NEK1	0.52709385
34	INSRR	0.50035418
35	EIF2AK3	0.49528634
36	PIK3CA	0.48259989
37	FRK	0.47273381
38	DYRK2	0.45794878
39	OXSR1	0.45156566
40	MAP3K8	0.42905922
41	PHKG1	0.42448932
42	PHKG2	0.42448932
43	BUB1	0.37401150
44	MUSK	0.36656873
45	PLK3	0.35792017
46	BMPR1B	0.35394499
47	CSNK1A1	0.34819836
48	KIT	0.34569432
49	TEC	0.34075847
50	KDR	0.33723349
51	PINK1	0.31852026
52	MAP3K12	0.30502982
53	MAP3K1	0.30239999
54	CASK	0.29595414
55	BCKDK	0.29344668
56	MYLK	0.27966685
57	PLK2	0.26949412
58	PDK2	0.26807653
59	TAOK3	0.26494343
60	PAK3	0.26332538
61	CSNK2A2	0.26196088
62	GRK7	0.26182081
63	PASK	0.25816213
64	OBSCN	0.25511351
65	CSNK2A1	0.25456103
66	PIK3CG	0.24564999
67	MAP2K6	0.23978891
68	EIF2AK1	0.23925249
69	IGF1R	0.22105930
70	GRK5	0.21953306
71	EPHB2	0.21899116
72	PRKCD	0.21658114
73	DAPK3	0.21523517
74	PRKCG	0.20978834
75	DAPK1	0.20880901
76	CDK8	0.18673580
77	CSNK1G3	0.18486113
78	MAP2K7	0.18405106
79	PRKACA	0.17937024
80	IKBKB	0.17438497
81	ABL1	0.17385536
82	SYK	0.15751645
83	PRKCA	0.14768570
84	CSNK1G1	0.14462526
85	ADRBK1	0.14128247
86	CSNK1G2	0.13689722
87	MAPK13	0.13239038
88	TGFBR1	0.12605860
89	AURKA	0.12401576
90	PBK	0.12349962
91	EIF2AK2	0.12190010
92	MARK1	0.11898168
93	NME1	0.11474119
94	CSNK1E	0.11330537
95	ITK	0.11171790
96	CAMK2A	0.09335304
97	MAPK15	0.08802347
98	MAP4K1	0.07572913
99	CSNK1A1L	0.07572584
100	PLK4	0.06825720

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	4.87014797
2	Proteasome_Homo sapiens_hsa03050	4.19624461
3	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	3.72619333
4	RNA polymerase_Homo sapiens_hsa03020	3.04135679
5	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.91034312
6	Oxidative phosphorylation_Homo sapiens_hsa00190	2.64362587
7	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.41821174
8	One carbon pool by folate_Homo sapiens_hsa00670	2.36572293
9	Ribosome_Homo sapiens_hsa03010	2.36396253
10	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.22263762
11	Parkinsons disease_Homo sapiens_hsa05012	2.08356917
12	Caffeine metabolism_Homo sapiens_hsa00232	2.02877331
13	Butanoate metabolism_Homo sapiens_hsa00650	1.85074438
14	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.75967157
15	Fatty acid elongation_Homo sapiens_hsa00062	1.71589042
16	Linoleic acid metabolism_Homo sapiens_hsa00591	1.69239623
17	Tryptophan metabolism_Homo sapiens_hsa00380	1.67511507
18	Asthma_Homo sapiens_hsa05310	1.64818964
19	Huntingtons disease_Homo sapiens_hsa05016	1.58100413
20	Taste transduction_Homo sapiens_hsa04742	1.57166579
21	Propanoate metabolism_Homo sapiens_hsa00640	1.57059904
22	Protein export_Homo sapiens_hsa03060	1.53541309
23	Phototransduction_Homo sapiens_hsa04744	1.50404314
24	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.43071421
25	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.39233410
26	Nitrogen metabolism_Homo sapiens_hsa00910	1.34929491
27	Allograft rejection_Homo sapiens_hsa05330	1.31497949
28	Primary immunodeficiency_Homo sapiens_hsa05340	1.31235164
29	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.29776726
30	Folate biosynthesis_Homo sapiens_hsa00790	1.27906632
31	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.27886678
32	Alzheimers disease_Homo sapiens_hsa05010	1.26128201
33	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.25241322
34	Nucleotide excision repair_Homo sapiens_hsa03420	1.23535901
35	Cardiac muscle contraction_Homo sapiens_hsa04260	1.21155190
36	beta-Alanine metabolism_Homo sapiens_hsa00410	1.19169511
37	Glycerolipid metabolism_Homo sapiens_hsa00561	1.12093374
38	Graft-versus-host disease_Homo sapiens_hsa05332	1.09645014
39	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.08323878
40	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.07583673
41	Ether lipid metabolism_Homo sapiens_hsa00565	1.07091402
42	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.05752553
43	Peroxisome_Homo sapiens_hsa04146	1.04657162
44	Type I diabetes mellitus_Homo sapiens_hsa04940	1.02718245
45	Pyrimidine metabolism_Homo sapiens_hsa00240	1.02141737
46	Sulfur relay system_Homo sapiens_hsa04122	0.99973504
47	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.93607833
48	Fatty acid degradation_Homo sapiens_hsa00071	0.89203566
49	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.86683568
50	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.81887116
51	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.80261095
52	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.78404558
53	Basal transcription factors_Homo sapiens_hsa03022	0.78248622
54	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.77444454
55	Purine metabolism_Homo sapiens_hsa00230	0.74568019
56	Viral myocarditis_Homo sapiens_hsa05416	0.71028973
57	Lysine degradation_Homo sapiens_hsa00310	0.70228671
58	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.67888388
59	Homologous recombination_Homo sapiens_hsa03440	0.65541110
60	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.64980759
61	RNA degradation_Homo sapiens_hsa03018	0.64947201
62	Retinol metabolism_Homo sapiens_hsa00830	0.64493432
63	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.63767961
64	Antigen processing and presentation_Homo sapiens_hsa04612	0.63252355
65	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.63067598
66	Fat digestion and absorption_Homo sapiens_hsa04975	0.62796906
67	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.62602854
68	Chemical carcinogenesis_Homo sapiens_hsa05204	0.61699008
69	Nicotine addiction_Homo sapiens_hsa05033	0.61501790
70	RNA transport_Homo sapiens_hsa03013	0.57348815
71	Mismatch repair_Homo sapiens_hsa03430	0.55457165
72	Metabolic pathways_Homo sapiens_hsa01100	0.55193185
73	Rheumatoid arthritis_Homo sapiens_hsa05323	0.53850350
74	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.53637147
75	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.53191910
76	Fatty acid metabolism_Homo sapiens_hsa01212	0.46667151
77	Olfactory transduction_Homo sapiens_hsa04740	0.45906658
78	Mineral absorption_Homo sapiens_hsa04978	0.45709964
79	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.45555889
80	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.44211663
81	Steroid biosynthesis_Homo sapiens_hsa00100	0.43803596
82	DNA replication_Homo sapiens_hsa03030	0.42454171
83	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.40682691
84	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.39053250
85	Fanconi anemia pathway_Homo sapiens_hsa03460	0.38160766
86	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.37437476
87	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.36875469
88	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.34713716
89	Collecting duct acid secretion_Homo sapiens_hsa04966	0.34044854
90	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.33629548
91	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.33022512
92	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.32210306
93	Non-homologous end-joining_Homo sapiens_hsa03450	0.29026653
94	Sulfur metabolism_Homo sapiens_hsa00920	0.28657276
95	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.26746887
96	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.22611626
97	Pyruvate metabolism_Homo sapiens_hsa00620	0.21511384
98	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.20213060
99	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.19172061
100	Morphine addiction_Homo sapiens_hsa05032	0.18767916

GAPDHP2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »