GAPDHP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of mitotic sister chromatid separation (GO:1901970)8.97396741
2positive regulation of mitotic metaphase/anaphase transition (GO:0045842)8.97396741
3positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)8.97396741
4negative regulation of Ras GTPase activity (GO:0034261)8.83130258
5ribosomal small subunit assembly (GO:0000028)8.11794934
6eosinophil chemotaxis (GO:0048245)7.89545752
7negative regulation of T cell receptor signaling pathway (GO:0050860)7.87785869
8fucose catabolic process (GO:0019317)7.36244195
9L-fucose metabolic process (GO:0042354)7.36244195
10L-fucose catabolic process (GO:0042355)7.36244195
11eosinophil migration (GO:0072677)7.14240353
12negative regulation of peptidyl-threonine phosphorylation (GO:0010801)6.73826673
13regulation of sister chromatid cohesion (GO:0007063)6.67042989
14regulation of mononuclear cell migration (GO:0071675)6.55882901
15negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)6.18246626
16positive regulation of chromosome segregation (GO:0051984)5.97916352
17branch elongation of an epithelium (GO:0060602)5.97777002
18vesicle fusion (GO:0006906)5.75067024
19coenzyme A biosynthetic process (GO:0015937)5.70091018
20negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)5.63901949
21autophagic vacuole fusion (GO:0000046)5.50381553
22macrophage chemotaxis (GO:0048246)4.93922769
23regulation of T cell receptor signaling pathway (GO:0050856)4.90981339
24positive regulation of calcium ion import (GO:0090280)4.70862424
25organelle membrane fusion (GO:0090174)4.51932995
26proteasome assembly (GO:0043248)4.50811847
27non-recombinational repair (GO:0000726)4.48071892
28double-strand break repair via nonhomologous end joining (GO:0006303)4.48071892
29organ growth (GO:0035265)4.46574573
30detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)4.39633300
31protein import into peroxisome matrix (GO:0016558)4.34722060
32oxidative demethylation (GO:0070989)4.31174560
33localization within membrane (GO:0051668)4.23252587
34monocyte chemotaxis (GO:0002548)4.21648870
35regulation of nitric-oxide synthase biosynthetic process (GO:0051769)4.20581707
36peptidyl-lysine dimethylation (GO:0018027)4.07310852
37axis elongation (GO:0003401)3.95799404
38fucosylation (GO:0036065)3.84779363
39regulation of beta-amyloid formation (GO:1902003)3.82598119
40chaperone-mediated protein transport (GO:0072321)3.80749572
41energy coupled proton transport, down electrochemical gradient (GO:0015985)3.80396276
42ATP synthesis coupled proton transport (GO:0015986)3.80396276
43establishment of mitotic spindle orientation (GO:0000132)3.78811074
44detection of chemical stimulus involved in sensory perception of taste (GO:0050912)3.78665264
45DNA deamination (GO:0045006)3.78356056
46mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.77488593
47preassembly of GPI anchor in ER membrane (GO:0016254)3.77433527
48folic acid-containing compound biosynthetic process (GO:0009396)3.73507927
49acrosome assembly (GO:0001675)3.68696094
50regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.67402618
51negative regulation of GTPase activity (GO:0034260)3.65423352
52negative regulation of GTP catabolic process (GO:0033125)3.65423352
53fucose metabolic process (GO:0006004)3.64908456
54seminiferous tubule development (GO:0072520)3.62910881
55pantothenate metabolic process (GO:0015939)3.61689930
56organelle fusion (GO:0048284)3.52172908
57protein neddylation (GO:0045116)3.46212592
58regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.45634908
59metallo-sulfur cluster assembly (GO:0031163)3.40502247
60iron-sulfur cluster assembly (GO:0016226)3.40502247
61establishment of mitotic spindle localization (GO:0040001)3.37829362
62purine nucleoside bisphosphate biosynthetic process (GO:0034033)3.28555496
63ribonucleoside bisphosphate biosynthetic process (GO:0034030)3.28555496
64nucleoside bisphosphate biosynthetic process (GO:0033866)3.28555496
65DNA demethylation (GO:0080111)3.26520410
66intracellular protein transmembrane import (GO:0044743)3.20582473
67regulation of autophagic vacuole assembly (GO:2000785)3.19254029
68negative regulation of circadian rhythm (GO:0042754)3.14810425
69positive chemotaxis (GO:0050918)3.14089575
70coenzyme A metabolic process (GO:0015936)3.13146056
71positive regulation of interleukin-1 beta secretion (GO:0050718)3.08404240
72single-organism membrane fusion (GO:0044801)3.06323107
73DNA integration (GO:0015074)3.05378867
74establishment of spindle orientation (GO:0051294)3.03992146
75ER to Golgi vesicle-mediated transport (GO:0006888)3.01580213
76sodium-independent organic anion transport (GO:0043252)3.00204593
77telomere maintenance via recombination (GO:0000722)2.99412321
78positive regulation of interleukin-1 secretion (GO:0050716)2.95393813
79regulation of fibroblast growth factor receptor signaling pathway (GO:0040036)2.90100401
80tRNA modification (GO:0006400)2.84591794
81mitochondrial RNA metabolic process (GO:0000959)2.84311395
82regulation of amyloid precursor protein catabolic process (GO:1902991)2.83441501
83protein targeting to peroxisome (GO:0006625)2.82813668
84establishment of protein localization to peroxisome (GO:0072663)2.82813668
85protein localization to peroxisome (GO:0072662)2.82813668
86regulation of interleukin-1 beta secretion (GO:0050706)2.82025433
87regulation of isotype switching to IgG isotypes (GO:0048302)2.80753094
88RNA methylation (GO:0001510)2.79871580
89transcription elongation from RNA polymerase III promoter (GO:0006385)2.76427544
90termination of RNA polymerase III transcription (GO:0006386)2.76427544
91regulation of cellular amino acid metabolic process (GO:0006521)2.76133237
92negative regulation of macroautophagy (GO:0016242)2.75510084
93histone H3-K9 methylation (GO:0051567)2.71438286
94GPI anchor metabolic process (GO:0006505)2.69801918
95GPI anchor biosynthetic process (GO:0006506)2.69672139
96regulation of T cell apoptotic process (GO:0070232)2.69270491
97regulation of stem cell maintenance (GO:2000036)2.68491127
98imidazole-containing compound metabolic process (GO:0052803)2.68035653
99prenylation (GO:0097354)10.2744482
100protein prenylation (GO:0018342)10.2744482

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse7.61885768
2GATA1_22025678_ChIP-Seq_K562_Human6.56958468
3VDR_22108803_ChIP-Seq_LS180_Human5.63700791
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.24741115
5NOTCH1_21737748_ChIP-Seq_TLL_Human3.86261236
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.53203725
7RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.31486373
8FLI1_27457419_Chip-Seq_LIVER_Mouse3.06182428
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.78774134
10YY1_21170310_ChIP-Seq_MESCs_Mouse2.51060819
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.48433308
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.32069915
13AR_21572438_ChIP-Seq_LNCaP_Human2.31589396
14PCGF2_27294783_Chip-Seq_ESCs_Mouse2.29559700
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.27655519
16CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.18025385
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.17956835
18SRF_21415370_ChIP-Seq_HL-1_Mouse2.15980559
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.05402495
20ZNF274_21170338_ChIP-Seq_K562_Hela1.97178802
21PCGF2_27294783_Chip-Seq_NPCs_Mouse1.96424363
22EST1_17652178_ChIP-ChIP_JURKAT_Human1.91696458
23VDR_23849224_ChIP-Seq_CD4+_Human1.86963375
24CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.85504036
25PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.80384881
26IRF1_19129219_ChIP-ChIP_H3396_Human1.74488090
27MYC_18555785_ChIP-Seq_MESCs_Mouse1.64924397
28ZNF263_19887448_ChIP-Seq_K562_Human1.61510389
29BCAT_22108803_ChIP-Seq_LS180_Human1.54622635
30SUZ12_27294783_Chip-Seq_NPCs_Mouse1.50879831
31TP53_22573176_ChIP-Seq_HFKS_Human1.50646264
32NFE2_27457419_Chip-Seq_LIVER_Mouse1.39609622
33ELK1_19687146_ChIP-ChIP_HELA_Human1.38927984
34SRY_22984422_ChIP-ChIP_TESTIS_Rat1.35687285
35GATA3_26560356_Chip-Seq_TH1_Human1.28326081
36P53_22127205_ChIP-Seq_FIBROBLAST_Human1.26940625
37TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.26272219
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.23414385
39HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.22450108
40FOXP3_21729870_ChIP-Seq_TREG_Human1.21049760
41FOXA1_25329375_ChIP-Seq_VCAP_Human1.20412120
42FOXA1_27270436_Chip-Seq_PROSTATE_Human1.20412120
43RXR_22108803_ChIP-Seq_LS180_Human1.18272400
44ZFP57_27257070_Chip-Seq_ESCs_Mouse1.14432818
45FOXH1_21741376_ChIP-Seq_EPCs_Human1.14040956
46TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11385315
47POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11385315
48NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.10770193
49POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.09922982
50MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.09471542
51GATA3_21878914_ChIP-Seq_MCF-7_Human1.06871614
52CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.06212513
53NANOG_19829295_ChIP-Seq_ESCs_Human1.06050742
54SOX2_19829295_ChIP-Seq_ESCs_Human1.06050742
55MYC_18358816_ChIP-ChIP_MESCs_Mouse1.02560553
56ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.02342883
57TAF15_26573619_Chip-Seq_HEK293_Human1.00540652
58ERG_20517297_ChIP-Seq_VCAP_Human0.99519926
59FUS_26573619_Chip-Seq_HEK293_Human0.98673219
60NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97674327
61EZH2_27294783_Chip-Seq_NPCs_Mouse0.96567175
62P300_19829295_ChIP-Seq_ESCs_Human0.96543185
63NANOG_20526341_ChIP-Seq_ESCs_Human0.94501741
64SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.92355751
65EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.92094283
66TCF4_22108803_ChIP-Seq_LS180_Human0.92064315
67AUTS2_25519132_ChIP-Seq_293T-REX_Human0.92026688
68AR_20517297_ChIP-Seq_VCAP_Human0.91843641
69GABP_19822575_ChIP-Seq_HepG2_Human0.89342535
70NCOR_22424771_ChIP-Seq_293T_Human0.87894884
71FOXH1_21741376_ChIP-Seq_ESCs_Human0.87386399
72CRX_20693478_ChIP-Seq_RETINA_Mouse0.86217284
73IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.85692140
74CREB1_15753290_ChIP-ChIP_HEK293T_Human0.84503745
75EZH2_22144423_ChIP-Seq_EOC_Human0.82232619
76KLF5_20875108_ChIP-Seq_MESCs_Mouse0.82034184
77STAT3_18555785_Chip-Seq_ESCs_Mouse0.81234292
78CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.81111177
79FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.80989212
80GBX2_23144817_ChIP-Seq_PC3_Human0.80180496
81ETV2_25802403_ChIP-Seq_MESCs_Mouse0.78260779
82OCT4_20526341_ChIP-Seq_ESCs_Human0.77991168
83IKZF1_21737484_ChIP-ChIP_HCT116_Human0.76866399
84DCP1A_22483619_ChIP-Seq_HELA_Human0.75947870
85ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.75867163
86IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.75451372
87CBP_20019798_ChIP-Seq_JUKART_Human0.75451372
88MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.74833063
89UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.74430815
90ELK1_22589737_ChIP-Seq_MCF10A_Human0.73745166
91EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.72362974
92THAP11_20581084_ChIP-Seq_MESCs_Mouse0.72124749
93RUNX_20019798_ChIP-Seq_JUKART_Human0.71473252
94PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.70893078
95HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.70555361
96MYC_19030024_ChIP-ChIP_MESCs_Mouse0.70123031
97KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.69876536
98EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.69804210
99CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.69355850
100TTF2_22483619_ChIP-Seq_HELA_Human0.69142068

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis9.95748181
2MP0003303_peritoneal_inflammation7.08867132
3MP0006082_CNS_inflammation4.37256878
4MP0001919_abnormal_reproductive_system3.04036795
5MP0001663_abnormal_digestive_system2.89070923
6MP0001664_abnormal_digestion2.57952521
7MP0002751_abnormal_autonomic_nervous2.31647531
8MP0005381_digestive/alimentary_phenotyp2.27255816
9MP0005389_reproductive_system_phenotype2.15226346
10MP0000383_abnormal_hair_follicle2.05132598
11MP0002876_abnormal_thyroid_physiology1.94876618
12MP0003011_delayed_dark_adaptation1.92349439
13MP0000467_abnormal_esophagus_morphology1.81375333
14MP0003195_calcinosis1.61102569
15MP0001293_anophthalmia1.60318084
16MP0005671_abnormal_response_to1.54308769
17MP0008872_abnormal_physiological_respon1.53969533
18MP0003115_abnormal_respiratory_system1.52663454
19MP0008875_abnormal_xenobiotic_pharmacok1.49533235
20MP0003763_abnormal_thymus_physiology1.46309057
21MP0000372_irregular_coat_pigmentation1.45491111
22MP0002102_abnormal_ear_morphology1.43339585
23MP0005166_decreased_susceptibility_to1.30162577
24MP0006292_abnormal_olfactory_placode1.26469707
25MP0000534_abnormal_ureter_morphology1.24765852
26MP0002837_dystrophic_cardiac_calcinosis1.23006325
27MP0003937_abnormal_limbs/digits/tail_de1.20760038
28MP0002138_abnormal_hepatobiliary_system1.18950991
29MP0004147_increased_porphyrin_level1.16191980
30MP0004142_abnormal_muscle_tone1.13282065
31MP0000490_abnormal_crypts_of1.12321335
32MP0005551_abnormal_eye_electrophysiolog1.11671737
33MP0006276_abnormal_autonomic_nervous1.11396333
34MP0001986_abnormal_taste_sensitivity1.10287970
35MP0001968_abnormal_touch/_nociception1.09243358
36MP0005253_abnormal_eye_physiology1.09082904
37MP0001873_stomach_inflammation1.05115328
38MP0010678_abnormal_skin_adnexa1.04803344
39MP0002736_abnormal_nociception_after1.01348768
40MP0001764_abnormal_homeostasis1.01287869
41MP0004782_abnormal_surfactant_physiolog1.00423578
42MP0001286_abnormal_eye_development0.98253381
43MP0002653_abnormal_ependyma_morphology0.95413339
44MP0008058_abnormal_DNA_repair0.95340345
45MP0005084_abnormal_gallbladder_morpholo0.94328518
46MP0002277_abnormal_respiratory_mucosa0.92904860
47MP0003646_muscle_fatigue0.89641946
48MP0003283_abnormal_digestive_organ0.89594670
49MP0004145_abnormal_muscle_electrophysio0.88239717
50MP0002163_abnormal_gland_morphology0.88093902
51MP0001800_abnormal_humoral_immune0.87611944
52MP0005645_abnormal_hypothalamus_physiol0.87156048
53MP0010155_abnormal_intestine_physiology0.86933539
54MP0008877_abnormal_DNA_methylation0.86932655
55MP0000026_abnormal_inner_ear0.86274248
56MP0001440_abnormal_grooming_behavior0.85230067
57MP0001835_abnormal_antigen_presentation0.84471972
58MP0001963_abnormal_hearing_physiology0.82743246
59MP0002210_abnormal_sex_determination0.81825923
60MP0002405_respiratory_system_inflammati0.79178551
61MP0006072_abnormal_retinal_apoptosis0.78718682
62MP0005387_immune_system_phenotype0.78401260
63MP0001790_abnormal_immune_system0.78401260
64MP0001915_intracranial_hemorrhage0.77131580
65MP0001529_abnormal_vocalization0.75362034
66MP0003806_abnormal_nucleotide_metabolis0.75359000
67MP0002019_abnormal_tumor_incidence0.74461151
68MP0001485_abnormal_pinna_reflex0.73995224
69MP0001984_abnormal_olfaction0.73329886
70MP0009764_decreased_sensitivity_to0.73304997
71MP0004885_abnormal_endolymph0.73053466
72MP0009785_altered_susceptibility_to0.72755002
73MP0000358_abnormal_cell_content/0.70303146
74MP0009745_abnormal_behavioral_response0.67219583
75MP0000685_abnormal_immune_system0.65688657
76MP0005000_abnormal_immune_tolerance0.65103123
77MP0003638_abnormal_response/metabolism_0.64653994
78MP0005332_abnormal_amino_acid0.64287280
79MP0003936_abnormal_reproductive_system0.64027217
80MP0000470_abnormal_stomach_morphology0.63881910
81MP0001905_abnormal_dopamine_level0.63734906
82MP0002184_abnormal_innervation0.63549110
83MP0004742_abnormal_vestibular_system0.62134207
84MP0002234_abnormal_pharynx_morphology0.62119627
85MP0005025_abnormal_response_to0.61977101
86MP0005501_abnormal_skin_physiology0.61425165
87MP0008789_abnormal_olfactory_epithelium0.60425197
88MP0002938_white_spotting0.60235558
89MP0002109_abnormal_limb_morphology0.60198712
90MP0002272_abnormal_nervous_system0.59896364
91MP0006036_abnormal_mitochondrial_physio0.59233057
92MP0002752_abnormal_somatic_nervous0.58842920
93MP0005085_abnormal_gallbladder_physiolo0.58842507
94MP0005499_abnormal_olfactory_system0.56812751
95MP0005394_taste/olfaction_phenotype0.56812751
96MP0009333_abnormal_splenocyte_physiolog0.56769838
97MP0005410_abnormal_fertilization0.55601449
98MP0002452_abnormal_antigen_presenting0.55121494
99MP0002638_abnormal_pupillary_reflex0.54495942
100MP0001970_abnormal_pain_threshold0.54387115

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of long-chain fatty-acid metabolism (HP:0010964)7.54392732
2Duplicated collecting system (HP:0000081)7.09489239
3Large for gestational age (HP:0001520)6.50477165
4Abnormality of the renal collecting system (HP:0004742)6.48009055
5Long foot (HP:0001833)5.69352904
6Adactyly (HP:0009776)5.13962547
7Acute lymphatic leukemia (HP:0006721)4.28106259
8Abnormality of fatty-acid metabolism (HP:0004359)4.05958006
9Dry hair (HP:0011359)4.01045029
10Hypoplastic pelvis (HP:0008839)3.90483953
11Progressive muscle weakness (HP:0003323)3.65886408
12Brushfield spots (HP:0001088)3.63699876
13Ureteral stenosis (HP:0000071)3.62137920
14Ureteral duplication (HP:0000073)3.57822525
15Ureteral obstruction (HP:0006000)3.51399185
16Steatorrhea (HP:0002570)3.45985018
17Hypoplastic nipples (HP:0002557)3.42843258
18Acute necrotizing encephalopathy (HP:0006965)3.36374639
19Increased hepatocellular lipid droplets (HP:0006565)3.25743820
20Pulmonary artery stenosis (HP:0004415)3.24158513
21Broad-based gait (HP:0002136)3.21431237
22Severe muscular hypotonia (HP:0006829)3.19496531
23Mitochondrial inheritance (HP:0001427)3.09918426
24Autoamputation (HP:0001218)3.04107197
25Menstrual irregularities (HP:0000858)2.98486778
26Lipid accumulation in hepatocytes (HP:0006561)2.93306624
27Lactic acidosis (HP:0003128)2.86013788
28Reduced subcutaneous adipose tissue (HP:0003758)2.82561409
29Increased CSF lactate (HP:0002490)2.80707308
30Acute encephalopathy (HP:0006846)2.79586634
31Abnormal mitochondria in muscle tissue (HP:0008316)2.76615149
32Wide intermamillary distance (HP:0006610)2.74863068
33Increased serum lactate (HP:0002151)2.70502959
34Abnormal auditory evoked potentials (HP:0006958)2.69153181
35Decreased muscle mass (HP:0003199)2.68247151
36Progressive macrocephaly (HP:0004481)2.66662283
37Clubbing of toes (HP:0100760)2.61331346
38Renal Fanconi syndrome (HP:0001994)2.54554528
39Anhidrosis (HP:0000970)2.51663465
40Fat malabsorption (HP:0002630)2.51096317
41Polyneuropathy (HP:0001271)2.47323900
42Chorioretinal coloboma (HP:0000567)2.39934868
43Sudden death (HP:0001699)2.39179766
44Hepatocellular necrosis (HP:0001404)2.37818326
45Congenital stationary night blindness (HP:0007642)2.37723307
46Increased number of teeth (HP:0011069)2.35969936
473-Methylglutaconic aciduria (HP:0003535)2.35314776
48Exercise intolerance (HP:0003546)2.28603528
49Congenital, generalized hypertrichosis (HP:0004540)2.28596117
50Abnormality of midbrain morphology (HP:0002418)2.23746791
51Molar tooth sign on MRI (HP:0002419)2.23746791
52Polymicrogyria (HP:0002126)2.23045627
53Palmoplantar hyperkeratosis (HP:0000972)2.16738648
54Exertional dyspnea (HP:0002875)2.14928282
55Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.13985897
56Abnormality of the labia minora (HP:0012880)2.11040171
57Basal ganglia calcification (HP:0002135)2.10822901
58Hepatic necrosis (HP:0002605)2.07045931
59Respiratory failure (HP:0002878)2.06967581
60Widely spaced teeth (HP:0000687)2.06257165
61Transposition of the great arteries (HP:0001669)2.06177857
62Abnormal connection of the cardiac segments (HP:0011545)2.06177857
63Abnormal ventriculo-arterial connection (HP:0011563)2.06177857
64Palmar hyperkeratosis (HP:0010765)1.98114992
65Pancreatic cysts (HP:0001737)1.97298661
66Posterior embryotoxon (HP:0000627)1.96576999
67Optic disc pallor (HP:0000543)1.95395307
68Abnormality of the line of Schwalbe (HP:0008048)1.93996081
69Abnormality of vision evoked potentials (HP:0000649)1.93016293
70Epiphyseal stippling (HP:0010655)1.92811682
71Cerebral edema (HP:0002181)1.90659612
72Female pseudohermaphroditism (HP:0010458)1.90136889
73Anxiety (HP:0000739)1.88744533
74CNS demyelination (HP:0007305)1.86953051
75Rhabdomyolysis (HP:0003201)1.84269850
76True hermaphroditism (HP:0010459)1.83639236
77Spastic tetraplegia (HP:0002510)1.82852754
78Hypoplastic iliac wings (HP:0002866)1.82746450
79Aplasia/Hypoplasia of the nipples (HP:0006709)1.82045379
80Dynein arm defect of respiratory motile cilia (HP:0012255)1.78317212
81Absent/shortened dynein arms (HP:0200106)1.78317212
82Decreased lacrimation (HP:0000633)1.78007015
83Increased intramyocellular lipid droplets (HP:0012240)1.75314327
84Oral leukoplakia (HP:0002745)1.73194089
85Gangrene (HP:0100758)1.73125317
86Flat face (HP:0012368)1.72693106
87Plantar hyperkeratosis (HP:0007556)1.70125818
88Depressed nasal ridge (HP:0000457)1.69900655
89Pancreatic fibrosis (HP:0100732)1.69716882
90IgG deficiency (HP:0004315)1.67510968
91Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.66892542
92Parakeratosis (HP:0001036)1.65658094
93Medial flaring of the eyebrow (HP:0010747)1.65535669
94Decreased electroretinogram (ERG) amplitude (HP:0000654)1.65055879
95Abolished electroretinogram (ERG) (HP:0000550)1.64861057
96Myoglobinuria (HP:0002913)1.64099793
97Abnormality of renal resorption (HP:0011038)1.63417176
98Hypoproteinemia (HP:0003075)1.63000633
99Hypomagnesemia (HP:0002917)1.62701812
100Pendular nystagmus (HP:0012043)1.62533229

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MKNK16.34773638
2TAOK24.70119233
3TAOK14.52542271
4MAP3K33.63476250
5MAP3K113.55387837
6MAP2K33.00226446
7JAK32.07673665
8MKNK210.7666971
9ABL21.83778907
10DYRK1A1.70419153
11SRPK11.70210079
12VRK21.39498424
13TLK11.31818482
14MAP3K51.06376332
15TIE11.04925349
16WNK41.00156653
17ZAK0.94699178
18ADRBK20.94606711
19TSSK60.89792769
20GRK10.87705035
21TXK0.83907304
22CHEK20.79004548
23MST40.73455569
24NUAK10.73201032
25MAP4K20.71235979
26TRIM280.70678663
27STK390.70647445
28PRKCQ0.70355762
29VRK10.68304203
30WNK30.61951847
31TAF10.58102787
32STK160.53702270
33NEK10.52709385
34INSRR0.50035418
35EIF2AK30.49528634
36PIK3CA0.48259989
37FRK0.47273381
38DYRK20.45794878
39OXSR10.45156566
40MAP3K80.42905922
41PHKG10.42448932
42PHKG20.42448932
43BUB10.37401150
44MUSK0.36656873
45PLK30.35792017
46BMPR1B0.35394499
47CSNK1A10.34819836
48KIT0.34569432
49TEC0.34075847
50KDR0.33723349
51PINK10.31852026
52MAP3K120.30502982
53MAP3K10.30239999
54CASK0.29595414
55BCKDK0.29344668
56MYLK0.27966685
57PLK20.26949412
58PDK20.26807653
59TAOK30.26494343
60PAK30.26332538
61CSNK2A20.26196088
62GRK70.26182081
63PASK0.25816213
64OBSCN0.25511351
65CSNK2A10.25456103
66PIK3CG0.24564999
67MAP2K60.23978891
68EIF2AK10.23925249
69IGF1R0.22105930
70GRK50.21953306
71EPHB20.21899116
72PRKCD0.21658114
73DAPK30.21523517
74PRKCG0.20978834
75DAPK10.20880901
76CDK80.18673580
77CSNK1G30.18486113
78MAP2K70.18405106
79PRKACA0.17937024
80IKBKB0.17438497
81ABL10.17385536
82SYK0.15751645
83PRKCA0.14768570
84CSNK1G10.14462526
85ADRBK10.14128247
86CSNK1G20.13689722
87MAPK130.13239038
88TGFBR10.12605860
89AURKA0.12401576
90PBK0.12349962
91EIF2AK20.12190010
92MARK10.11898168
93NME10.11474119
94CSNK1E0.11330537
95ITK0.11171790
96CAMK2A0.09335304
97MAPK150.08802347
98MAP4K10.07572913
99CSNK1A1L0.07572584
100PLK40.06825720

Predicted pathways (KEGG)

RankGene SetZ-score
1SNARE interactions in vesicular transport_Homo sapiens_hsa041304.87014797
2Proteasome_Homo sapiens_hsa030504.19624461
3Pantothenate and CoA biosynthesis_Homo sapiens_hsa007703.72619333
4RNA polymerase_Homo sapiens_hsa030203.04135679
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.91034312
6Oxidative phosphorylation_Homo sapiens_hsa001902.64362587
7Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.41821174
8One carbon pool by folate_Homo sapiens_hsa006702.36572293
9Ribosome_Homo sapiens_hsa030102.36396253
10Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.22263762
11Parkinsons disease_Homo sapiens_hsa050122.08356917
12Caffeine metabolism_Homo sapiens_hsa002322.02877331
13Butanoate metabolism_Homo sapiens_hsa006501.85074438
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.75967157
15Fatty acid elongation_Homo sapiens_hsa000621.71589042
16Linoleic acid metabolism_Homo sapiens_hsa005911.69239623
17Tryptophan metabolism_Homo sapiens_hsa003801.67511507
18Asthma_Homo sapiens_hsa053101.64818964
19Huntingtons disease_Homo sapiens_hsa050161.58100413
20Taste transduction_Homo sapiens_hsa047421.57166579
21Propanoate metabolism_Homo sapiens_hsa006401.57059904
22Protein export_Homo sapiens_hsa030601.53541309
23Phototransduction_Homo sapiens_hsa047441.50404314
24Intestinal immune network for IgA production_Homo sapiens_hsa046721.43071421
25alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.39233410
26Nitrogen metabolism_Homo sapiens_hsa009101.34929491
27Allograft rejection_Homo sapiens_hsa053301.31497949
28Primary immunodeficiency_Homo sapiens_hsa053401.31235164
29Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.29776726
30Folate biosynthesis_Homo sapiens_hsa007901.27906632
31Autoimmune thyroid disease_Homo sapiens_hsa053201.27886678
32Alzheimers disease_Homo sapiens_hsa050101.26128201
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.25241322
34Nucleotide excision repair_Homo sapiens_hsa034201.23535901
35Cardiac muscle contraction_Homo sapiens_hsa042601.21155190
36beta-Alanine metabolism_Homo sapiens_hsa004101.19169511
37Glycerolipid metabolism_Homo sapiens_hsa005611.12093374
38Graft-versus-host disease_Homo sapiens_hsa053321.09645014
39Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.08323878
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.07583673
41Ether lipid metabolism_Homo sapiens_hsa005651.07091402
42Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.05752553
43Peroxisome_Homo sapiens_hsa041461.04657162
44Type I diabetes mellitus_Homo sapiens_hsa049401.02718245
45Pyrimidine metabolism_Homo sapiens_hsa002401.02141737
46Sulfur relay system_Homo sapiens_hsa041220.99973504
47Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.93607833
48Fatty acid degradation_Homo sapiens_hsa000710.89203566
49Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.86683568
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.81887116
51Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.80261095
52Maturity onset diabetes of the young_Homo sapiens_hsa049500.78404558
53Basal transcription factors_Homo sapiens_hsa030220.78248622
54Hematopoietic cell lineage_Homo sapiens_hsa046400.77444454
55Purine metabolism_Homo sapiens_hsa002300.74568019
56Viral myocarditis_Homo sapiens_hsa054160.71028973
57Lysine degradation_Homo sapiens_hsa003100.70228671
58Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.67888388
59Homologous recombination_Homo sapiens_hsa034400.65541110
60Steroid hormone biosynthesis_Homo sapiens_hsa001400.64980759
61RNA degradation_Homo sapiens_hsa030180.64947201
62Retinol metabolism_Homo sapiens_hsa008300.64493432
63Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.63767961
64Antigen processing and presentation_Homo sapiens_hsa046120.63252355
65Arachidonic acid metabolism_Homo sapiens_hsa005900.63067598
66Fat digestion and absorption_Homo sapiens_hsa049750.62796906
67Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.62602854
68Chemical carcinogenesis_Homo sapiens_hsa052040.61699008
69Nicotine addiction_Homo sapiens_hsa050330.61501790
70RNA transport_Homo sapiens_hsa030130.57348815
71Mismatch repair_Homo sapiens_hsa034300.55457165
72Metabolic pathways_Homo sapiens_hsa011000.55193185
73Rheumatoid arthritis_Homo sapiens_hsa053230.53850350
74Pentose and glucuronate interconversions_Homo sapiens_hsa000400.53637147
75Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.53191910
76Fatty acid metabolism_Homo sapiens_hsa012120.46667151
77Olfactory transduction_Homo sapiens_hsa047400.45906658
78Mineral absorption_Homo sapiens_hsa049780.45709964
79Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.45555889
80Epstein-Barr virus infection_Homo sapiens_hsa051690.44211663
81Steroid biosynthesis_Homo sapiens_hsa001000.43803596
82DNA replication_Homo sapiens_hsa030300.42454171
83Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.40682691
84Vitamin digestion and absorption_Homo sapiens_hsa049770.39053250
85Fanconi anemia pathway_Homo sapiens_hsa034600.38160766
86Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.37437476
87Glycerophospholipid metabolism_Homo sapiens_hsa005640.36875469
88Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.34713716
89Collecting duct acid secretion_Homo sapiens_hsa049660.34044854
90Cysteine and methionine metabolism_Homo sapiens_hsa002700.33629548
91Systemic lupus erythematosus_Homo sapiens_hsa053220.33022512
92Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.32210306
93Non-homologous end-joining_Homo sapiens_hsa034500.29026653
94Sulfur metabolism_Homo sapiens_hsa009200.28657276
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.26746887
96Drug metabolism - other enzymes_Homo sapiens_hsa009830.22611626
97Pyruvate metabolism_Homo sapiens_hsa006200.21511384
98Primary bile acid biosynthesis_Homo sapiens_hsa001200.20213060
99Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.19172061
100Morphine addiction_Homo sapiens_hsa050320.18767916

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