

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA deamination (GO:0045006) | 6.11159756 |
| 2 | proteasome assembly (GO:0043248) | 5.35081395 |
| 3 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 5.19953478 |
| 4 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 4.48655773 |
| 5 | ATP synthesis coupled proton transport (GO:0015986) | 4.48655773 |
| 6 | protein neddylation (GO:0045116) | 4.17841428 |
| 7 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 4.15957678 |
| 8 | maturation of 5.8S rRNA (GO:0000460) | 4.07942803 |
| 9 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 4.07631414 |
| 10 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.07205536 |
| 11 | cullin deneddylation (GO:0010388) | 4.06386235 |
| 12 | rRNA modification (GO:0000154) | 4.03475678 |
| 13 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 4.02636965 |
| 14 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 4.01606266 |
| 15 | water-soluble vitamin biosynthetic process (GO:0042364) | 3.99260701 |
| 16 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.98854639 |
| 17 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.98854639 |
| 18 | pseudouridine synthesis (GO:0001522) | 3.95296880 |
| 19 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.90143286 |
| 20 | chaperone-mediated protein transport (GO:0072321) | 3.87231007 |
| 21 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.85561007 |
| 22 | GTP biosynthetic process (GO:0006183) | 3.83014980 |
| 23 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.78023080 |
| 24 | negative regulation of ligase activity (GO:0051352) | 3.67183643 |
| 25 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.67183643 |
| 26 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.65920207 |
| 27 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.65869172 |
| 28 | protein deneddylation (GO:0000338) | 3.65522306 |
| 29 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.61620137 |
| 30 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.61620137 |
| 31 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.61620137 |
| 32 | respiratory chain complex IV assembly (GO:0008535) | 3.60078277 |
| 33 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.59743532 |
| 34 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.59743532 |
| 35 | rRNA methylation (GO:0031167) | 3.53635822 |
| 36 | pteridine-containing compound biosynthetic process (GO:0042559) | 3.51592465 |
| 37 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.46338026 |
| 38 | negative regulation of thymocyte apoptotic process (GO:0070244) | 3.45287490 |
| 39 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.44520583 |
| 40 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.44520583 |
| 41 | ribosome assembly (GO:0042255) | 3.43236697 |
| 42 | replication fork processing (GO:0031297) | 3.41143360 |
| 43 | UTP biosynthetic process (GO:0006228) | 3.41110078 |
| 44 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.38991061 |
| 45 | termination of RNA polymerase III transcription (GO:0006386) | 3.32905134 |
| 46 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.32905134 |
| 47 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 3.30789852 |
| 48 | protein complex biogenesis (GO:0070271) | 3.29393933 |
| 49 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.23278669 |
| 50 | intracellular protein transmembrane import (GO:0044743) | 3.22707196 |
| 51 | DNA strand renaturation (GO:0000733) | 3.17699425 |
| 52 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.13571083 |
| 53 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.10835239 |
| 54 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.10835239 |
| 55 | NADH dehydrogenase complex assembly (GO:0010257) | 3.10835239 |
| 56 | peptidyl-histidine modification (GO:0018202) | 3.08033334 |
| 57 | UTP metabolic process (GO:0046051) | 3.07009984 |
| 58 | cytochrome complex assembly (GO:0017004) | 3.06922395 |
| 59 | protein K6-linked ubiquitination (GO:0085020) | 3.05259267 |
| 60 | protein targeting to mitochondrion (GO:0006626) | 3.04094856 |
| 61 | positive regulation of ligase activity (GO:0051351) | 3.01413108 |
| 62 | regulation of chronic inflammatory response (GO:0002676) | 3.01030496 |
| 63 | amino acid activation (GO:0043038) | 3.00722713 |
| 64 | tRNA aminoacylation (GO:0043039) | 3.00722713 |
| 65 | rRNA processing (GO:0006364) | 3.00202036 |
| 66 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 2.98703665 |
| 67 | DNA double-strand break processing (GO:0000729) | 2.97152760 |
| 68 | electron transport chain (GO:0022900) | 2.95819114 |
| 69 | DNA catabolic process, exonucleolytic (GO:0000738) | 2.92815143 |
| 70 | respiratory electron transport chain (GO:0022904) | 2.92367623 |
| 71 | rRNA metabolic process (GO:0016072) | 2.92185403 |
| 72 | protein localization to mitochondrion (GO:0070585) | 2.91571858 |
| 73 | guanosine-containing compound biosynthetic process (GO:1901070) | 2.91246227 |
| 74 | RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503) | 2.90129365 |
| 75 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 2.89234470 |
| 76 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 2.88828931 |
| 77 | tRNA aminoacylation for protein translation (GO:0006418) | 2.88640197 |
| 78 | tRNA processing (GO:0008033) | 2.87803875 |
| 79 | tRNA metabolic process (GO:0006399) | 2.87542385 |
| 80 | IMP biosynthetic process (GO:0006188) | 2.87367218 |
| 81 | amino acid salvage (GO:0043102) | 2.86812399 |
| 82 | L-methionine salvage (GO:0071267) | 2.86812399 |
| 83 | L-methionine biosynthetic process (GO:0071265) | 2.86812399 |
| 84 | pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148) | 2.85385469 |
| 85 | negative regulation of protein ubiquitination (GO:0031397) | 2.80796530 |
| 86 | negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804) | 2.80791790 |
| 87 | establishment of protein localization to mitochondrion (GO:0072655) | 2.80332510 |
| 88 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 2.80059270 |
| 89 | kynurenine metabolic process (GO:0070189) | 2.78918296 |
| 90 | organelle disassembly (GO:1903008) | 2.78093562 |
| 91 | DNA replication checkpoint (GO:0000076) | 2.76481852 |
| 92 | maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005) | 2.75747724 |
| 93 | positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141) | 2.75020601 |
| 94 | regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139) | 2.75020601 |
| 95 | inner mitochondrial membrane organization (GO:0007007) | 2.74991396 |
| 96 | DNA damage response, detection of DNA damage (GO:0042769) | 2.74048980 |
| 97 | regulation of cellular amine metabolic process (GO:0033238) | 2.74034427 |
| 98 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 2.73893575 |
| 99 | protein-cofactor linkage (GO:0018065) | 2.73695968 |
| 100 | positive regulation of cell cycle arrest (GO:0071158) | 2.73599682 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 5.35101213 |
| 2 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.81341066 |
| 3 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 4.17298356 |
| 4 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.67757126 |
| 5 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.58597843 |
| 6 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 3.49609520 |
| 7 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.31275961 |
| 8 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.07734795 |
| 9 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.93728110 |
| 10 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.71446770 |
| 11 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.67081960 |
| 12 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.61154514 |
| 13 | VDR_22108803_ChIP-Seq_LS180_Human | 2.55772757 |
| 14 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.54638235 |
| 15 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.49701609 |
| 16 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.42600436 |
| 17 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.28786269 |
| 18 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.28078127 |
| 19 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.26637860 |
| 20 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 2.17221507 |
| 21 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.14949287 |
| 22 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.13069833 |
| 23 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.12585356 |
| 24 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.02754673 |
| 25 | E2F7_22180533_ChIP-Seq_HELA_Human | 1.91781383 |
| 26 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.80795277 |
| 27 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.80528185 |
| 28 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.75171738 |
| 29 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.73929572 |
| 30 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.70090656 |
| 31 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.69086840 |
| 32 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.67210456 |
| 33 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.66886915 |
| 34 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.66651533 |
| 35 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.66423022 |
| 36 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.60837800 |
| 37 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.59188233 |
| 38 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.55844736 |
| 39 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.53005513 |
| 40 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.52620462 |
| 41 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.52184609 |
| 42 | EWS_26573619_Chip-Seq_HEK293_Human | 1.51087954 |
| 43 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.47540714 |
| 44 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.47389931 |
| 45 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.45299724 |
| 46 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.44171726 |
| 47 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.41670281 |
| 48 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.38580129 |
| 49 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.35237494 |
| 50 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.30617854 |
| 51 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.30548203 |
| 52 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.26315748 |
| 53 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.25999615 |
| 54 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.25573896 |
| 55 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.24891897 |
| 56 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.22634097 |
| 57 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.20281413 |
| 58 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.20083017 |
| 59 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 1.19854284 |
| 60 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.16389161 |
| 61 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.14297807 |
| 62 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.12597889 |
| 63 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.10583649 |
| 64 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.10192546 |
| 65 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.09873425 |
| 66 | FUS_26573619_Chip-Seq_HEK293_Human | 1.08276073 |
| 67 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 1.07657134 |
| 68 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.07371635 |
| 69 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.07031245 |
| 70 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.06835397 |
| 71 | NCOR_22424771_ChIP-Seq_293T_Human | 1.06298822 |
| 72 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.02914842 |
| 73 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.02914842 |
| 74 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.02290527 |
| 75 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.01537672 |
| 76 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.99239448 |
| 77 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 0.99087380 |
| 78 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.98145139 |
| 79 | P300_19829295_ChIP-Seq_ESCs_Human | 0.97665433 |
| 80 | AR_20517297_ChIP-Seq_VCAP_Human | 0.97292165 |
| 81 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 0.97168060 |
| 82 | SOX2_19829295_ChIP-Seq_ESCs_Human | 0.96024186 |
| 83 | NANOG_19829295_ChIP-Seq_ESCs_Human | 0.96024186 |
| 84 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.95853354 |
| 85 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 0.95157706 |
| 86 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 0.94447518 |
| 87 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 0.94108698 |
| 88 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 0.91899922 |
| 89 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 0.90208417 |
| 90 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.89410436 |
| 91 | CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse | 0.88141986 |
| 92 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 0.88138040 |
| 93 | GATA3_21878914_ChIP-Seq_MCF-7_Human | 0.87842867 |
| 94 | ER_23166858_ChIP-Seq_MCF-7_Human | 0.87675561 |
| 95 | CEBPA_26348894_ChIP-Seq_LIVER_Mouse | 0.86431893 |
| 96 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.86259860 |
| 97 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 0.86140053 |
| 98 | FOXH1_21741376_ChIP-Seq_EPCs_Human | 0.85910447 |
| 99 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 0.84568126 |
| 100 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 0.82851951 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0004147_increased_porphyrin_level | 4.14372600 |
| 2 | MP0003011_delayed_dark_adaptation | 4.04503568 |
| 3 | MP0005084_abnormal_gallbladder_morpholo | 3.32872331 |
| 4 | MP0003806_abnormal_nucleotide_metabolis | 3.13230480 |
| 5 | MP0008877_abnormal_DNA_methylation | 2.84152851 |
| 6 | MP0001873_stomach_inflammation | 2.75921869 |
| 7 | MP0004957_abnormal_blastocyst_morpholog | 2.75401386 |
| 8 | MP0008872_abnormal_physiological_respon | 2.64249405 |
| 9 | MP0003186_abnormal_redox_activity | 2.51338134 |
| 10 | MP0003693_abnormal_embryo_hatching | 2.50605344 |
| 11 | MP0006036_abnormal_mitochondrial_physio | 2.49874577 |
| 12 | MP0008875_abnormal_xenobiotic_pharmacok | 2.41932321 |
| 13 | MP0008058_abnormal_DNA_repair | 2.36596157 |
| 14 | MP0009697_abnormal_copulation | 2.34236781 |
| 15 | MP0010094_abnormal_chromosome_stability | 2.26431282 |
| 16 | MP0006072_abnormal_retinal_apoptosis | 2.21278092 |
| 17 | MP0003718_maternal_effect | 2.12542965 |
| 18 | MP0004145_abnormal_muscle_electrophysio | 2.03559636 |
| 19 | MP0006035_abnormal_mitochondrial_morpho | 2.02103657 |
| 20 | MP0005671_abnormal_response_to | 1.90159781 |
| 21 | MP0005551_abnormal_eye_electrophysiolog | 1.82496415 |
| 22 | MP0003786_premature_aging | 1.77957391 |
| 23 | MP0005167_abnormal_blood-brain_barrier | 1.69390588 |
| 24 | MP0001835_abnormal_antigen_presentation | 1.67400665 |
| 25 | MP0001501_abnormal_sleep_pattern | 1.62586851 |
| 26 | MP0004215_abnormal_myocardial_fiber | 1.62312853 |
| 27 | MP0004142_abnormal_muscle_tone | 1.59551087 |
| 28 | MP0003111_abnormal_nucleus_morphology | 1.56472068 |
| 29 | MP0002837_dystrophic_cardiac_calcinosis | 1.53636287 |
| 30 | MP0002102_abnormal_ear_morphology | 1.53462258 |
| 31 | MP0000685_abnormal_immune_system | 1.51557080 |
| 32 | MP0009333_abnormal_splenocyte_physiolog | 1.42769250 |
| 33 | MP0008007_abnormal_cellular_replicative | 1.38174664 |
| 34 | MP0008775_abnormal_heart_ventricle | 1.36639723 |
| 35 | MP0002148_abnormal_hypersensitivity_rea | 1.35992764 |
| 36 | MP0002736_abnormal_nociception_after | 1.35509833 |
| 37 | MP0003646_muscle_fatigue | 1.34812568 |
| 38 | MP0002138_abnormal_hepatobiliary_system | 1.30208460 |
| 39 | MP0009764_decreased_sensitivity_to | 1.29681939 |
| 40 | MP0003077_abnormal_cell_cycle | 1.28587085 |
| 41 | MP0001905_abnormal_dopamine_level | 1.28221536 |
| 42 | MP0001764_abnormal_homeostasis | 1.25121628 |
| 43 | MP0005085_abnormal_gallbladder_physiolo | 1.24510604 |
| 44 | MP0005379_endocrine/exocrine_gland_phen | 1.22554806 |
| 45 | MP0002876_abnormal_thyroid_physiology | 1.20493907 |
| 46 | MP0003880_abnormal_central_pattern | 1.18771454 |
| 47 | MP0001919_abnormal_reproductive_system | 1.18361390 |
| 48 | MP0004782_abnormal_surfactant_physiolog | 1.15334842 |
| 49 | MP0006292_abnormal_olfactory_placode | 1.14705246 |
| 50 | MP0002272_abnormal_nervous_system | 1.13274966 |
| 51 | MP0001485_abnormal_pinna_reflex | 1.13027228 |
| 52 | MP0005253_abnormal_eye_physiology | 1.10738910 |
| 53 | MP0004019_abnormal_vitamin_homeostasis | 1.08371840 |
| 54 | MP0001968_abnormal_touch/_nociception | 1.06846047 |
| 55 | MP0005636_abnormal_mineral_homeostasis | 1.06411844 |
| 56 | MP0005645_abnormal_hypothalamus_physiol | 1.04723464 |
| 57 | MP0005448_abnormal_energy_balance | 1.02579816 |
| 58 | MP0002938_white_spotting | 1.02390079 |
| 59 | MP0005083_abnormal_biliary_tract | 1.02254536 |
| 60 | MP0005389_reproductive_system_phenotype | 1.01618062 |
| 61 | MP0005165_increased_susceptibility_to | 1.01521886 |
| 62 | MP0000358_abnormal_cell_content/ | 1.00899112 |
| 63 | MP0009785_altered_susceptibility_to | 1.00085377 |
| 64 | MP0008873_increased_physiological_sensi | 0.97483780 |
| 65 | MP0002210_abnormal_sex_determination | 0.97373467 |
| 66 | MP0002234_abnormal_pharynx_morphology | 0.93994526 |
| 67 | MP0009745_abnormal_behavioral_response | 0.93176461 |
| 68 | MP0003195_calcinosis | 0.92413935 |
| 69 | MP0000372_irregular_coat_pigmentation | 0.91170730 |
| 70 | MP0005646_abnormal_pituitary_gland | 0.87987984 |
| 71 | MP0003943_abnormal_hepatobiliary_system | 0.84979547 |
| 72 | MP0001293_anophthalmia | 0.84926692 |
| 73 | MP0002006_tumorigenesis | 0.83676661 |
| 74 | MP0002163_abnormal_gland_morphology | 0.82854860 |
| 75 | MP0002733_abnormal_thermal_nociception | 0.82284155 |
| 76 | MP0003252_abnormal_bile_duct | 0.81511220 |
| 77 | MP0001529_abnormal_vocalization | 0.80417969 |
| 78 | MP0009643_abnormal_urine_homeostasis | 0.76660728 |
| 79 | MP0003137_abnormal_impulse_conducting | 0.75991859 |
| 80 | MP0005365_abnormal_bile_salt | 0.75593215 |
| 81 | MP0004084_abnormal_cardiac_muscle | 0.75580764 |
| 82 | MP0003866_abnormal_defecation | 0.74521166 |
| 83 | MP0005332_abnormal_amino_acid | 0.73624436 |
| 84 | MP0000230_abnormal_systemic_arterial | 0.73445266 |
| 85 | MP0009046_muscle_twitch | 0.73368902 |
| 86 | MP0001929_abnormal_gametogenesis | 0.72910034 |
| 87 | MP0008932_abnormal_embryonic_tissue | 0.72866903 |
| 88 | MP0000427_abnormal_hair_cycle | 0.70818503 |
| 89 | MP0000653_abnormal_sex_gland | 0.69424218 |
| 90 | MP0001663_abnormal_digestive_system | 0.69393770 |
| 91 | MP0002653_abnormal_ependyma_morphology | 0.66959144 |
| 92 | MP0001986_abnormal_taste_sensitivity | 0.66905811 |
| 93 | MP0001984_abnormal_olfaction | 0.66599690 |
| 94 | MP0002136_abnormal_kidney_physiology | 0.66215776 |
| 95 | MP0005410_abnormal_fertilization | 0.65848585 |
| 96 | MP0005310_abnormal_salivary_gland | 0.65770026 |
| 97 | MP0002160_abnormal_reproductive_system | 0.65098907 |
| 98 | MP0009765_abnormal_xenobiotic_induced | 0.64307591 |
| 99 | MP0008057_abnormal_DNA_replication | 0.63997192 |
| 100 | MP0002282_abnormal_trachea_morphology | 0.60454682 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 4.64957216 |
| 2 | Acute encephalopathy (HP:0006846) | 4.23674335 |
| 3 | Increased CSF lactate (HP:0002490) | 4.20238067 |
| 4 | Hepatocellular necrosis (HP:0001404) | 4.20114929 |
| 5 | Abnormal mitochondria in muscle tissue (HP:0008316) | 4.08738077 |
| 6 | Mitochondrial inheritance (HP:0001427) | 4.04424953 |
| 7 | Hepatic necrosis (HP:0002605) | 3.84858636 |
| 8 | Progressive macrocephaly (HP:0004481) | 3.74519868 |
| 9 | 3-Methylglutaconic aciduria (HP:0003535) | 3.47709060 |
| 10 | Increased serum lactate (HP:0002151) | 3.46784233 |
| 11 | Increased serum pyruvate (HP:0003542) | 3.45973969 |
| 12 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 3.44516130 |
| 13 | Abnormality of alanine metabolism (HP:0010916) | 3.44516130 |
| 14 | Hyperalaninemia (HP:0003348) | 3.44516130 |
| 15 | Increased hepatocellular lipid droplets (HP:0006565) | 3.17148332 |
| 16 | Pancreatic cysts (HP:0001737) | 3.09549519 |
| 17 | Abnormality of glycolysis (HP:0004366) | 3.07996134 |
| 18 | Degeneration of anterior horn cells (HP:0002398) | 3.07538232 |
| 19 | Abnormality of the anterior horn cell (HP:0006802) | 3.07538232 |
| 20 | Cerebral edema (HP:0002181) | 3.02771091 |
| 21 | Lipid accumulation in hepatocytes (HP:0006561) | 3.01990036 |
| 22 | Optic disc pallor (HP:0000543) | 2.92349862 |
| 23 | Abnormality of the labia minora (HP:0012880) | 2.83269357 |
| 24 | Lactic acidosis (HP:0003128) | 2.76013672 |
| 25 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.66561953 |
| 26 | Pancreatic fibrosis (HP:0100732) | 2.59520421 |
| 27 | Abnormality of the renal cortex (HP:0011035) | 2.56414894 |
| 28 | Congenital stationary night blindness (HP:0007642) | 2.43015710 |
| 29 | Aplastic anemia (HP:0001915) | 2.41025104 |
| 30 | Respiratory failure (HP:0002878) | 2.39348105 |
| 31 | True hermaphroditism (HP:0010459) | 2.37492239 |
| 32 | Hypomagnesemia (HP:0002917) | 2.31541484 |
| 33 | Exercise intolerance (HP:0003546) | 2.31395059 |
| 34 | Colon cancer (HP:0003003) | 2.31166462 |
| 35 | Abnormality of placental membranes (HP:0011409) | 2.30774345 |
| 36 | Amniotic constriction ring (HP:0009775) | 2.30774345 |
| 37 | Lethargy (HP:0001254) | 2.30712384 |
| 38 | Inability to walk (HP:0002540) | 2.29038815 |
| 39 | Delayed CNS myelination (HP:0002188) | 2.28530900 |
| 40 | Methylmalonic aciduria (HP:0012120) | 2.27213719 |
| 41 | Tubular atrophy (HP:0000092) | 2.26628325 |
| 42 | Leukodystrophy (HP:0002415) | 2.24851362 |
| 43 | Progressive inability to walk (HP:0002505) | 2.22795580 |
| 44 | Methylmalonic acidemia (HP:0002912) | 2.21819846 |
| 45 | CNS demyelination (HP:0007305) | 2.21128447 |
| 46 | Renal Fanconi syndrome (HP:0001994) | 2.19441790 |
| 47 | Congenital, generalized hypertrichosis (HP:0004540) | 2.18510090 |
| 48 | Abnormality of the pons (HP:0007361) | 2.18144365 |
| 49 | Pendular nystagmus (HP:0012043) | 2.17830697 |
| 50 | Hypoplasia of the pons (HP:0012110) | 2.17492646 |
| 51 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.17315754 |
| 52 | Adrenal hypoplasia (HP:0000835) | 2.14713479 |
| 53 | Abnormality of magnesium homeostasis (HP:0004921) | 2.12234027 |
| 54 | Abnormal biliary tract physiology (HP:0012439) | 2.11754649 |
| 55 | Bile duct proliferation (HP:0001408) | 2.11754649 |
| 56 | Pancytopenia (HP:0001876) | 2.10831526 |
| 57 | Pancreatic islet-cell hyperplasia (HP:0004510) | 2.09291956 |
| 58 | Spinal muscular atrophy (HP:0007269) | 2.06623908 |
| 59 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.04992643 |
| 60 | Abnormal drinking behavior (HP:0030082) | 2.04501125 |
| 61 | Polydipsia (HP:0001959) | 2.04501125 |
| 62 | Type I transferrin isoform profile (HP:0003642) | 2.04015581 |
| 63 | Nephronophthisis (HP:0000090) | 2.03994360 |
| 64 | Abnormality of midbrain morphology (HP:0002418) | 2.01552014 |
| 65 | Molar tooth sign on MRI (HP:0002419) | 2.01552014 |
| 66 | Renal cortical cysts (HP:0000803) | 2.01349434 |
| 67 | CNS hypomyelination (HP:0003429) | 1.99283876 |
| 68 | Hypoglycemic coma (HP:0001325) | 1.96726303 |
| 69 | Volvulus (HP:0002580) | 1.96125051 |
| 70 | Exertional dyspnea (HP:0002875) | 1.94257850 |
| 71 | Abnormality of serum amino acid levels (HP:0003112) | 1.93795073 |
| 72 | Medial flaring of the eyebrow (HP:0010747) | 1.93175347 |
| 73 | Abolished electroretinogram (ERG) (HP:0000550) | 1.93063917 |
| 74 | Polyuria (HP:0000103) | 1.92586619 |
| 75 | Glycosuria (HP:0003076) | 1.90687774 |
| 76 | Abnormality of urine glucose concentration (HP:0011016) | 1.90687774 |
| 77 | Hyperinsulinemic hypoglycemia (HP:0000825) | 1.90491740 |
| 78 | X-linked dominant inheritance (HP:0001423) | 1.90395839 |
| 79 | Abnormality of the ileum (HP:0001549) | 1.90096947 |
| 80 | Cerebral hypomyelination (HP:0006808) | 1.89208738 |
| 81 | Meckel diverticulum (HP:0002245) | 1.88144461 |
| 82 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 1.85100927 |
| 83 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 1.85100927 |
| 84 | Symptomatic seizures (HP:0011145) | 1.82597752 |
| 85 | Keratoconus (HP:0000563) | 1.80661593 |
| 86 | Increased corneal curvature (HP:0100692) | 1.80661593 |
| 87 | Abnormality of the renal medulla (HP:0100957) | 1.79034525 |
| 88 | Microvesicular hepatic steatosis (HP:0001414) | 1.76437501 |
| 89 | Attenuation of retinal blood vessels (HP:0007843) | 1.76376008 |
| 90 | Parakeratosis (HP:0001036) | 1.76047692 |
| 91 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 1.75203081 |
| 92 | Emotional lability (HP:0000712) | 1.72831892 |
| 93 | Increased intramyocellular lipid droplets (HP:0012240) | 1.71402329 |
| 94 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 1.70703140 |
| 95 | Opisthotonus (HP:0002179) | 1.70076590 |
| 96 | Tongue fasciculations (HP:0001308) | 1.69491854 |
| 97 | Hyperglycinemia (HP:0002154) | 1.69344041 |
| 98 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.68181848 |
| 99 | Sclerocornea (HP:0000647) | 1.66962906 |
| 100 | Constricted visual fields (HP:0001133) | 1.64649039 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MST4 | 4.74832033 |
| 2 | VRK2 | 3.68839845 |
| 3 | BUB1 | 3.41259487 |
| 4 | TRIM28 | 3.37090861 |
| 5 | NUAK1 | 3.22755434 |
| 6 | TSSK6 | 2.90255650 |
| 7 | TIE1 | 2.88451471 |
| 8 | TLK1 | 2.81911202 |
| 9 | STK39 | 2.76908021 |
| 10 | MAP3K12 | 2.68643936 |
| 11 | BMPR1B | 2.68604427 |
| 12 | EIF2AK3 | 2.58280678 |
| 13 | NEK1 | 2.51958315 |
| 14 | INSRR | 2.19167249 |
| 15 | WNK4 | 2.12917787 |
| 16 | TAF1 | 2.09745070 |
| 17 | ZAK | 2.07967315 |
| 18 | VRK1 | 1.92704953 |
| 19 | EIF2AK1 | 1.90065029 |
| 20 | GRK1 | 1.81802448 |
| 21 | TNIK | 1.73343518 |
| 22 | NME1 | 1.68293773 |
| 23 | PLK3 | 1.66501826 |
| 24 | PBK | 1.39857835 |
| 25 | TGFBR1 | 1.36105154 |
| 26 | OXSR1 | 1.34661214 |
| 27 | STK38L | 1.28716105 |
| 28 | ADRBK2 | 1.26568605 |
| 29 | DAPK1 | 1.20901431 |
| 30 | TAOK3 | 1.19000606 |
| 31 | CDC7 | 1.18455551 |
| 32 | EIF2AK2 | 1.14306388 |
| 33 | PINK1 | 1.13552586 |
| 34 | PASK | 1.08557971 |
| 35 | SRPK1 | 1.07834949 |
| 36 | STK16 | 1.00051726 |
| 37 | CDK8 | 0.99047919 |
| 38 | MAP4K2 | 0.98761496 |
| 39 | BCKDK | 0.97810971 |
| 40 | PHKG1 | 0.96241337 |
| 41 | PHKG2 | 0.96241337 |
| 42 | SIK3 | 0.95323243 |
| 43 | WNK3 | 0.94353954 |
| 44 | MYLK | 0.85085104 |
| 45 | ACVR1B | 0.84142735 |
| 46 | PLK2 | 0.82142288 |
| 47 | MAPKAPK3 | 0.81086098 |
| 48 | TXK | 0.79691964 |
| 49 | CSNK1A1L | 0.77302834 |
| 50 | STK3 | 0.77127842 |
| 51 | PDK2 | 0.75563398 |
| 52 | BMPR2 | 0.71160289 |
| 53 | MKNK2 | 0.69991430 |
| 54 | PLK1 | 0.65690931 |
| 55 | CSNK1G3 | 0.61631250 |
| 56 | TTK | 0.60461914 |
| 57 | MAPKAPK5 | 0.57228105 |
| 58 | PRKCI | 0.56788969 |
| 59 | SMG1 | 0.56788902 |
| 60 | ALK | 0.54378400 |
| 61 | GRK5 | 0.51857627 |
| 62 | PIK3CG | 0.51803133 |
| 63 | DYRK2 | 0.50689285 |
| 64 | PRKCQ | 0.50415036 |
| 65 | BCR | 0.49299693 |
| 66 | MST1R | 0.49128106 |
| 67 | PRKCG | 0.47636866 |
| 68 | ATR | 0.47626078 |
| 69 | CASK | 0.46884674 |
| 70 | CSNK1G1 | 0.46366507 |
| 71 | PLK4 | 0.45611555 |
| 72 | AURKB | 0.43659416 |
| 73 | CDK9 | 0.43524783 |
| 74 | MKNK1 | 0.43219843 |
| 75 | NME2 | 0.42134758 |
| 76 | PTK2B | 0.39893563 |
| 77 | DAPK3 | 0.39840765 |
| 78 | ADRBK1 | 0.38599673 |
| 79 | TEC | 0.38472224 |
| 80 | FGFR1 | 0.37787327 |
| 81 | RIPK4 | 0.37605807 |
| 82 | CHEK2 | 0.37350454 |
| 83 | STK24 | 0.37125706 |
| 84 | FRK | 0.37064229 |
| 85 | CSNK2A2 | 0.36391188 |
| 86 | MAP3K4 | 0.35543294 |
| 87 | CSNK1G2 | 0.32278960 |
| 88 | WEE1 | 0.31725750 |
| 89 | CDK7 | 0.30969265 |
| 90 | PRKCE | 0.30232242 |
| 91 | ILK | 0.29520331 |
| 92 | STK10 | 0.29325751 |
| 93 | CCNB1 | 0.29279169 |
| 94 | FLT3 | 0.28986988 |
| 95 | CSNK2A1 | 0.27971538 |
| 96 | MAP2K7 | 0.27909266 |
| 97 | ATM | 0.27856672 |
| 98 | MAP2K6 | 0.27044262 |
| 99 | CSNK1A1 | 0.25700332 |
| 100 | CHEK1 | 0.24503344 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 5.22100236 |
| 2 | Protein export_Homo sapiens_hsa03060 | 3.76059566 |
| 3 | RNA polymerase_Homo sapiens_hsa03020 | 3.04792636 |
| 4 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.93984490 |
| 5 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.81784730 |
| 6 | Parkinsons disease_Homo sapiens_hsa05012 | 2.52832906 |
| 7 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.45933100 |
| 8 | Mismatch repair_Homo sapiens_hsa03430 | 2.28270478 |
| 9 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.23728656 |
| 10 | Homologous recombination_Homo sapiens_hsa03440 | 2.14836046 |
| 11 | RNA degradation_Homo sapiens_hsa03018 | 2.11483989 |
| 12 | Ribosome_Homo sapiens_hsa03010 | 1.98310910 |
| 13 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.94524443 |
| 14 | DNA replication_Homo sapiens_hsa03030 | 1.87697050 |
| 15 | Huntingtons disease_Homo sapiens_hsa05016 | 1.78045298 |
| 16 | Basal transcription factors_Homo sapiens_hsa03022 | 1.77491484 |
| 17 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.64911491 |
| 18 | RNA transport_Homo sapiens_hsa03013 | 1.64359098 |
| 19 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 1.62839818 |
| 20 | Alzheimers disease_Homo sapiens_hsa05010 | 1.61182803 |
| 21 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.59860349 |
| 22 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.56429610 |
| 23 | Base excision repair_Homo sapiens_hsa03410 | 1.50841543 |
| 24 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.50295111 |
| 25 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.38401877 |
| 26 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.38336697 |
| 27 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.38223292 |
| 28 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.34530279 |
| 29 | Purine metabolism_Homo sapiens_hsa00230 | 1.34342757 |
| 30 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.34310753 |
| 31 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.31414693 |
| 32 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.26976490 |
| 33 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.20313535 |
| 34 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.17279458 |
| 35 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.15097761 |
| 36 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.13544456 |
| 37 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.11601121 |
| 38 | Phototransduction_Homo sapiens_hsa04744 | 1.11016765 |
| 39 | Regulation of autophagy_Homo sapiens_hsa04140 | 1.08583587 |
| 40 | Spliceosome_Homo sapiens_hsa03040 | 1.07242398 |
| 41 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.02640646 |
| 42 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.02499752 |
| 43 | Peroxisome_Homo sapiens_hsa04146 | 1.01271693 |
| 44 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.00289949 |
| 45 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.97325526 |
| 46 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.95248524 |
| 47 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.94738334 |
| 48 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.91923665 |
| 49 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.91321471 |
| 50 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.90944533 |
| 51 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.89833085 |
| 52 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.87478062 |
| 53 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.86985945 |
| 54 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.86029447 |
| 55 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.83175489 |
| 56 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.79212753 |
| 57 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.78329842 |
| 58 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.77950385 |
| 59 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.75532248 |
| 60 | Metabolic pathways_Homo sapiens_hsa01100 | 0.74828362 |
| 61 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.74597693 |
| 62 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.73800397 |
| 63 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.72323140 |
| 64 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.71798620 |
| 65 | Asthma_Homo sapiens_hsa05310 | 0.68233832 |
| 66 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.67513198 |
| 67 | Allograft rejection_Homo sapiens_hsa05330 | 0.65932688 |
| 68 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.65726793 |
| 69 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.64359372 |
| 70 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.63632533 |
| 71 | Carbon metabolism_Homo sapiens_hsa01200 | 0.62500458 |
| 72 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.59907480 |
| 73 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.54218120 |
| 74 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.53668888 |
| 75 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.50435050 |
| 76 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.49181921 |
| 77 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.47844538 |
| 78 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.44460971 |
| 79 | Olfactory transduction_Homo sapiens_hsa04740 | 0.42319927 |
| 80 | Retinol metabolism_Homo sapiens_hsa00830 | 0.41982871 |
| 81 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.40436521 |
| 82 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.40403225 |
| 83 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.40005116 |
| 84 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.39884753 |
| 85 | Cell cycle_Homo sapiens_hsa04110 | 0.39598942 |
| 86 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.37242650 |
| 87 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.35180350 |
| 88 | Mineral absorption_Homo sapiens_hsa04978 | 0.34818643 |
| 89 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.34420915 |
| 90 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.32161298 |
| 91 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.32145317 |
| 92 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.31060845 |
| 93 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.27398981 |
| 94 | Morphine addiction_Homo sapiens_hsa05032 | 0.27003268 |
| 95 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.26729059 |
| 96 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.26422846 |
| 97 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.26277355 |
| 98 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.21187018 |
| 99 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.20742901 |
| 100 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.20405663 |

