GAPDHP20

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.11159756
2proteasome assembly (GO:0043248)5.35081395
3establishment of protein localization to mitochondrial membrane (GO:0090151)5.19953478
4energy coupled proton transport, down electrochemical gradient (GO:0015985)4.48655773
5ATP synthesis coupled proton transport (GO:0015986)4.48655773
6protein neddylation (GO:0045116)4.17841428
7mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.15957678
8maturation of 5.8S rRNA (GO:0000460)4.07942803
9exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 4.07631414
10negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.07205536
11cullin deneddylation (GO:0010388)4.06386235
12rRNA modification (GO:0000154)4.03475678
13nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)4.02636965
14regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.01606266
15water-soluble vitamin biosynthetic process (GO:0042364)3.99260701
16tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.98854639
17RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.98854639
18pseudouridine synthesis (GO:0001522)3.95296880
19regulation of cellular amino acid metabolic process (GO:0006521)3.90143286
20chaperone-mediated protein transport (GO:0072321)3.87231007
21folic acid-containing compound biosynthetic process (GO:0009396)3.85561007
22GTP biosynthetic process (GO:0006183)3.83014980
23positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.78023080
24negative regulation of ligase activity (GO:0051352)3.67183643
25negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.67183643
26DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.65920207
27regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.65869172
28protein deneddylation (GO:0000338)3.65522306
29signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.61620137
30signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.61620137
31signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.61620137
32respiratory chain complex IV assembly (GO:0008535)3.60078277
33intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.59743532
34signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.59743532
35rRNA methylation (GO:0031167)3.53635822
36pteridine-containing compound biosynthetic process (GO:0042559)3.51592465
37anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.46338026
38negative regulation of thymocyte apoptotic process (GO:0070244)3.45287490
39signal transduction involved in DNA integrity checkpoint (GO:0072401)3.44520583
40signal transduction involved in DNA damage checkpoint (GO:0072422)3.44520583
41ribosome assembly (GO:0042255)3.43236697
42replication fork processing (GO:0031297)3.41143360
43UTP biosynthetic process (GO:0006228)3.41110078
44signal transduction involved in cell cycle checkpoint (GO:0072395)3.38991061
45termination of RNA polymerase III transcription (GO:0006386)3.32905134
46transcription elongation from RNA polymerase III promoter (GO:0006385)3.32905134
47L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.30789852
48protein complex biogenesis (GO:0070271)3.29393933
49positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.23278669
50intracellular protein transmembrane import (GO:0044743)3.22707196
51DNA strand renaturation (GO:0000733)3.17699425
52mitochondrial respiratory chain complex assembly (GO:0033108)3.13571083
53mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.10835239
54mitochondrial respiratory chain complex I assembly (GO:0032981)3.10835239
55NADH dehydrogenase complex assembly (GO:0010257)3.10835239
56peptidyl-histidine modification (GO:0018202)3.08033334
57UTP metabolic process (GO:0046051)3.07009984
58cytochrome complex assembly (GO:0017004)3.06922395
59protein K6-linked ubiquitination (GO:0085020)3.05259267
60protein targeting to mitochondrion (GO:0006626)3.04094856
61positive regulation of ligase activity (GO:0051351)3.01413108
62regulation of chronic inflammatory response (GO:0002676)3.01030496
63amino acid activation (GO:0043038)3.00722713
64tRNA aminoacylation (GO:0043039)3.00722713
65rRNA processing (GO:0006364)3.00202036
66purine nucleoside triphosphate biosynthetic process (GO:0009145)2.98703665
67DNA double-strand break processing (GO:0000729)2.97152760
68electron transport chain (GO:0022900)2.95819114
69DNA catabolic process, exonucleolytic (GO:0000738)2.92815143
70respiratory electron transport chain (GO:0022904)2.92367623
71rRNA metabolic process (GO:0016072)2.92185403
72protein localization to mitochondrion (GO:0070585)2.91571858
73guanosine-containing compound biosynthetic process (GO:1901070)2.91246227
74RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.90129365
75purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.89234470
76mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.88828931
77tRNA aminoacylation for protein translation (GO:0006418)2.88640197
78tRNA processing (GO:0008033)2.87803875
79tRNA metabolic process (GO:0006399)2.87542385
80IMP biosynthetic process (GO:0006188)2.87367218
81amino acid salvage (GO:0043102)2.86812399
82L-methionine salvage (GO:0071267)2.86812399
83L-methionine biosynthetic process (GO:0071265)2.86812399
84pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.85385469
85negative regulation of protein ubiquitination (GO:0031397)2.80796530
86negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.80791790
87establishment of protein localization to mitochondrion (GO:0072655)2.80332510
88DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.80059270
89kynurenine metabolic process (GO:0070189)2.78918296
90organelle disassembly (GO:1903008)2.78093562
91DNA replication checkpoint (GO:0000076)2.76481852
92maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.75747724
93positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)2.75020601
94regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)2.75020601
95inner mitochondrial membrane organization (GO:0007007)2.74991396
96DNA damage response, detection of DNA damage (GO:0042769)2.74048980
97regulation of cellular amine metabolic process (GO:0033238)2.74034427
98regulation of ubiquitin-protein transferase activity (GO:0051438)2.73893575
99protein-cofactor linkage (GO:0018065)2.73695968
100positive regulation of cell cycle arrest (GO:0071158)2.73599682

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.35101213
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.81341066
3EST1_17652178_ChIP-ChIP_JURKAT_Human4.17298356
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.67757126
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.58597843
6ELF1_17652178_ChIP-ChIP_JURKAT_Human3.49609520
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.31275961
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.07734795
9CREB1_15753290_ChIP-ChIP_HEK293T_Human2.93728110
10VDR_23849224_ChIP-Seq_CD4+_Human2.71446770
11ELK1_19687146_ChIP-ChIP_HELA_Human2.67081960
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.61154514
13VDR_22108803_ChIP-Seq_LS180_Human2.55772757
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.54638235
15E2F4_17652178_ChIP-ChIP_JURKAT_Human2.49701609
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.42600436
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.28786269
18SRF_21415370_ChIP-Seq_HL-1_Mouse2.28078127
19PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.26637860
20FLI1_27457419_Chip-Seq_LIVER_Mouse2.17221507
21ZNF274_21170338_ChIP-Seq_K562_Hela2.14949287
22FOXP3_21729870_ChIP-Seq_TREG_Human2.13069833
23DCP1A_22483619_ChIP-Seq_HELA_Human2.12585356
24MYC_18358816_ChIP-ChIP_MESCs_Mouse2.02754673
25E2F7_22180533_ChIP-Seq_HELA_Human1.91781383
26FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.80795277
27MYC_19030024_ChIP-ChIP_MESCs_Mouse1.80528185
28PCGF2_27294783_Chip-Seq_ESCs_Mouse1.75171738
29GABP_19822575_ChIP-Seq_HepG2_Human1.73929572
30PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.70090656
31BP1_19119308_ChIP-ChIP_Hs578T_Human1.69086840
32PADI4_21655091_ChIP-ChIP_MCF-7_Human1.67210456
33EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.66886915
34SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.66651533
35YY1_21170310_ChIP-Seq_MESCs_Mouse1.66423022
36HOXB4_20404135_ChIP-ChIP_EML_Mouse1.60837800
37HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.59188233
38THAP11_20581084_ChIP-Seq_MESCs_Mouse1.55844736
39MYC_18940864_ChIP-ChIP_HL60_Human1.53005513
40MYC_19079543_ChIP-ChIP_MESCs_Mouse1.52620462
41E2F1_18555785_ChIP-Seq_MESCs_Mouse1.52184609
42EWS_26573619_Chip-Seq_HEK293_Human1.51087954
43RBPJ_22232070_ChIP-Seq_NCS_Mouse1.47540714
44TTF2_22483619_ChIP-Seq_HELA_Human1.47389931
45FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.45299724
46EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.44171726
47NOTCH1_21737748_ChIP-Seq_TLL_Human1.41670281
48ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.38580129
49NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.35237494
50IRF1_19129219_ChIP-ChIP_H3396_Human1.30617854
51KDM5A_27292631_Chip-Seq_BREAST_Human1.30548203
52TP53_22573176_ChIP-Seq_HFKS_Human1.26315748
53ELK1_22589737_ChIP-Seq_MCF10A_Human1.25999615
54XRN2_22483619_ChIP-Seq_HELA_Human1.25573896
55PCGF2_27294783_Chip-Seq_NPCs_Mouse1.24891897
56YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.22634097
57HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.20281413
58TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20083017
59PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.19854284
60MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.16389161
61ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.14297807
62CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.12597889
63POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.10583649
64CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.10192546
65NELFA_20434984_ChIP-Seq_ESCs_Mouse1.09873425
66FUS_26573619_Chip-Seq_HEK293_Human1.08276073
67FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.07657134
68GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.07371635
69SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.07031245
70RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06835397
71NCOR_22424771_ChIP-Seq_293T_Human1.06298822
72FOXA1_25329375_ChIP-Seq_VCAP_Human1.02914842
73FOXA1_27270436_Chip-Seq_PROSTATE_Human1.02914842
74POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.02290527
75POU5F1_16153702_ChIP-ChIP_HESCs_Human1.01537672
76E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.99239448
77MYCN_18555785_ChIP-Seq_MESCs_Mouse0.99087380
78GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98145139
79P300_19829295_ChIP-Seq_ESCs_Human0.97665433
80AR_20517297_ChIP-Seq_VCAP_Human0.97292165
81IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.97168060
82SOX2_19829295_ChIP-Seq_ESCs_Human0.96024186
83NANOG_19829295_ChIP-Seq_ESCs_Human0.96024186
84DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.95853354
85EGR1_23403033_ChIP-Seq_LIVER_Mouse0.95157706
86AUTS2_25519132_ChIP-Seq_293T-REX_Human0.94447518
87KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.94108698
88MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.91899922
89GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.90208417
90FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89410436
91CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.88141986
92SUZ12_27294783_Chip-Seq_NPCs_Mouse0.88138040
93GATA3_21878914_ChIP-Seq_MCF-7_Human0.87842867
94ER_23166858_ChIP-Seq_MCF-7_Human0.87675561
95CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.86431893
96FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.86259860
97ERG_20887958_ChIP-Seq_HPC-7_Mouse0.86140053
98FOXH1_21741376_ChIP-Seq_EPCs_Human0.85910447
99NANOG_16153702_ChIP-ChIP_HESCs_Human0.84568126
100NFE2_27457419_Chip-Seq_LIVER_Mouse0.82851951

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004147_increased_porphyrin_level4.14372600
2MP0003011_delayed_dark_adaptation4.04503568
3MP0005084_abnormal_gallbladder_morpholo3.32872331
4MP0003806_abnormal_nucleotide_metabolis3.13230480
5MP0008877_abnormal_DNA_methylation2.84152851
6MP0001873_stomach_inflammation2.75921869
7MP0004957_abnormal_blastocyst_morpholog2.75401386
8MP0008872_abnormal_physiological_respon2.64249405
9MP0003186_abnormal_redox_activity2.51338134
10MP0003693_abnormal_embryo_hatching2.50605344
11MP0006036_abnormal_mitochondrial_physio2.49874577
12MP0008875_abnormal_xenobiotic_pharmacok2.41932321
13MP0008058_abnormal_DNA_repair2.36596157
14MP0009697_abnormal_copulation2.34236781
15MP0010094_abnormal_chromosome_stability2.26431282
16MP0006072_abnormal_retinal_apoptosis2.21278092
17MP0003718_maternal_effect2.12542965
18MP0004145_abnormal_muscle_electrophysio2.03559636
19MP0006035_abnormal_mitochondrial_morpho2.02103657
20MP0005671_abnormal_response_to1.90159781
21MP0005551_abnormal_eye_electrophysiolog1.82496415
22MP0003786_premature_aging1.77957391
23MP0005167_abnormal_blood-brain_barrier1.69390588
24MP0001835_abnormal_antigen_presentation1.67400665
25MP0001501_abnormal_sleep_pattern1.62586851
26MP0004215_abnormal_myocardial_fiber1.62312853
27MP0004142_abnormal_muscle_tone1.59551087
28MP0003111_abnormal_nucleus_morphology1.56472068
29MP0002837_dystrophic_cardiac_calcinosis1.53636287
30MP0002102_abnormal_ear_morphology1.53462258
31MP0000685_abnormal_immune_system1.51557080
32MP0009333_abnormal_splenocyte_physiolog1.42769250
33MP0008007_abnormal_cellular_replicative1.38174664
34MP0008775_abnormal_heart_ventricle1.36639723
35MP0002148_abnormal_hypersensitivity_rea1.35992764
36MP0002736_abnormal_nociception_after1.35509833
37MP0003646_muscle_fatigue1.34812568
38MP0002138_abnormal_hepatobiliary_system1.30208460
39MP0009764_decreased_sensitivity_to1.29681939
40MP0003077_abnormal_cell_cycle1.28587085
41MP0001905_abnormal_dopamine_level1.28221536
42MP0001764_abnormal_homeostasis1.25121628
43MP0005085_abnormal_gallbladder_physiolo1.24510604
44MP0005379_endocrine/exocrine_gland_phen1.22554806
45MP0002876_abnormal_thyroid_physiology1.20493907
46MP0003880_abnormal_central_pattern1.18771454
47MP0001919_abnormal_reproductive_system1.18361390
48MP0004782_abnormal_surfactant_physiolog1.15334842
49MP0006292_abnormal_olfactory_placode1.14705246
50MP0002272_abnormal_nervous_system1.13274966
51MP0001485_abnormal_pinna_reflex1.13027228
52MP0005253_abnormal_eye_physiology1.10738910
53MP0004019_abnormal_vitamin_homeostasis1.08371840
54MP0001968_abnormal_touch/_nociception1.06846047
55MP0005636_abnormal_mineral_homeostasis1.06411844
56MP0005645_abnormal_hypothalamus_physiol1.04723464
57MP0005448_abnormal_energy_balance1.02579816
58MP0002938_white_spotting1.02390079
59MP0005083_abnormal_biliary_tract1.02254536
60MP0005389_reproductive_system_phenotype1.01618062
61MP0005165_increased_susceptibility_to1.01521886
62MP0000358_abnormal_cell_content/1.00899112
63MP0009785_altered_susceptibility_to1.00085377
64MP0008873_increased_physiological_sensi0.97483780
65MP0002210_abnormal_sex_determination0.97373467
66MP0002234_abnormal_pharynx_morphology0.93994526
67MP0009745_abnormal_behavioral_response0.93176461
68MP0003195_calcinosis0.92413935
69MP0000372_irregular_coat_pigmentation0.91170730
70MP0005646_abnormal_pituitary_gland0.87987984
71MP0003943_abnormal_hepatobiliary_system0.84979547
72MP0001293_anophthalmia0.84926692
73MP0002006_tumorigenesis0.83676661
74MP0002163_abnormal_gland_morphology0.82854860
75MP0002733_abnormal_thermal_nociception0.82284155
76MP0003252_abnormal_bile_duct0.81511220
77MP0001529_abnormal_vocalization0.80417969
78MP0009643_abnormal_urine_homeostasis0.76660728
79MP0003137_abnormal_impulse_conducting0.75991859
80MP0005365_abnormal_bile_salt0.75593215
81MP0004084_abnormal_cardiac_muscle0.75580764
82MP0003866_abnormal_defecation0.74521166
83MP0005332_abnormal_amino_acid0.73624436
84MP0000230_abnormal_systemic_arterial0.73445266
85MP0009046_muscle_twitch0.73368902
86MP0001929_abnormal_gametogenesis0.72910034
87MP0008932_abnormal_embryonic_tissue0.72866903
88MP0000427_abnormal_hair_cycle0.70818503
89MP0000653_abnormal_sex_gland0.69424218
90MP0001663_abnormal_digestive_system0.69393770
91MP0002653_abnormal_ependyma_morphology0.66959144
92MP0001986_abnormal_taste_sensitivity0.66905811
93MP0001984_abnormal_olfaction0.66599690
94MP0002136_abnormal_kidney_physiology0.66215776
95MP0005410_abnormal_fertilization0.65848585
96MP0005310_abnormal_salivary_gland0.65770026
97MP0002160_abnormal_reproductive_system0.65098907
98MP0009765_abnormal_xenobiotic_induced0.64307591
99MP0008057_abnormal_DNA_replication0.63997192
100MP0002282_abnormal_trachea_morphology0.60454682

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.64957216
2Acute encephalopathy (HP:0006846)4.23674335
3Increased CSF lactate (HP:0002490)4.20238067
4Hepatocellular necrosis (HP:0001404)4.20114929
5Abnormal mitochondria in muscle tissue (HP:0008316)4.08738077
6Mitochondrial inheritance (HP:0001427)4.04424953
7Hepatic necrosis (HP:0002605)3.84858636
8Progressive macrocephaly (HP:0004481)3.74519868
93-Methylglutaconic aciduria (HP:0003535)3.47709060
10Increased serum lactate (HP:0002151)3.46784233
11Increased serum pyruvate (HP:0003542)3.45973969
12Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.44516130
13Abnormality of alanine metabolism (HP:0010916)3.44516130
14Hyperalaninemia (HP:0003348)3.44516130
15Increased hepatocellular lipid droplets (HP:0006565)3.17148332
16Pancreatic cysts (HP:0001737)3.09549519
17Abnormality of glycolysis (HP:0004366)3.07996134
18Degeneration of anterior horn cells (HP:0002398)3.07538232
19Abnormality of the anterior horn cell (HP:0006802)3.07538232
20Cerebral edema (HP:0002181)3.02771091
21Lipid accumulation in hepatocytes (HP:0006561)3.01990036
22Optic disc pallor (HP:0000543)2.92349862
23Abnormality of the labia minora (HP:0012880)2.83269357
24Lactic acidosis (HP:0003128)2.76013672
25Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.66561953
26Pancreatic fibrosis (HP:0100732)2.59520421
27Abnormality of the renal cortex (HP:0011035)2.56414894
28Congenital stationary night blindness (HP:0007642)2.43015710
29Aplastic anemia (HP:0001915)2.41025104
30Respiratory failure (HP:0002878)2.39348105
31True hermaphroditism (HP:0010459)2.37492239
32Hypomagnesemia (HP:0002917)2.31541484
33Exercise intolerance (HP:0003546)2.31395059
34Colon cancer (HP:0003003)2.31166462
35Abnormality of placental membranes (HP:0011409)2.30774345
36Amniotic constriction ring (HP:0009775)2.30774345
37Lethargy (HP:0001254)2.30712384
38Inability to walk (HP:0002540)2.29038815
39Delayed CNS myelination (HP:0002188)2.28530900
40Methylmalonic aciduria (HP:0012120)2.27213719
41Tubular atrophy (HP:0000092)2.26628325
42Leukodystrophy (HP:0002415)2.24851362
43Progressive inability to walk (HP:0002505)2.22795580
44Methylmalonic acidemia (HP:0002912)2.21819846
45CNS demyelination (HP:0007305)2.21128447
46Renal Fanconi syndrome (HP:0001994)2.19441790
47Congenital, generalized hypertrichosis (HP:0004540)2.18510090
48Abnormality of the pons (HP:0007361)2.18144365
49Pendular nystagmus (HP:0012043)2.17830697
50Hypoplasia of the pons (HP:0012110)2.17492646
51Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.17315754
52Adrenal hypoplasia (HP:0000835)2.14713479
53Abnormality of magnesium homeostasis (HP:0004921)2.12234027
54Abnormal biliary tract physiology (HP:0012439)2.11754649
55Bile duct proliferation (HP:0001408)2.11754649
56Pancytopenia (HP:0001876)2.10831526
57Pancreatic islet-cell hyperplasia (HP:0004510)2.09291956
58Spinal muscular atrophy (HP:0007269)2.06623908
59Aplasia/Hypoplasia of the uvula (HP:0010293)2.04992643
60Abnormal drinking behavior (HP:0030082)2.04501125
61Polydipsia (HP:0001959)2.04501125
62Type I transferrin isoform profile (HP:0003642)2.04015581
63Nephronophthisis (HP:0000090)2.03994360
64Abnormality of midbrain morphology (HP:0002418)2.01552014
65Molar tooth sign on MRI (HP:0002419)2.01552014
66Renal cortical cysts (HP:0000803)2.01349434
67CNS hypomyelination (HP:0003429)1.99283876
68Hypoglycemic coma (HP:0001325)1.96726303
69Volvulus (HP:0002580)1.96125051
70Exertional dyspnea (HP:0002875)1.94257850
71Abnormality of serum amino acid levels (HP:0003112)1.93795073
72Medial flaring of the eyebrow (HP:0010747)1.93175347
73Abolished electroretinogram (ERG) (HP:0000550)1.93063917
74Polyuria (HP:0000103)1.92586619
75Glycosuria (HP:0003076)1.90687774
76Abnormality of urine glucose concentration (HP:0011016)1.90687774
77Hyperinsulinemic hypoglycemia (HP:0000825)1.90491740
78X-linked dominant inheritance (HP:0001423)1.90395839
79Abnormality of the ileum (HP:0001549)1.90096947
80Cerebral hypomyelination (HP:0006808)1.89208738
81Meckel diverticulum (HP:0002245)1.88144461
82Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.85100927
83Decreased activity of mitochondrial respiratory chain (HP:0008972)1.85100927
84Symptomatic seizures (HP:0011145)1.82597752
85Keratoconus (HP:0000563)1.80661593
86Increased corneal curvature (HP:0100692)1.80661593
87Abnormality of the renal medulla (HP:0100957)1.79034525
88Microvesicular hepatic steatosis (HP:0001414)1.76437501
89Attenuation of retinal blood vessels (HP:0007843)1.76376008
90Parakeratosis (HP:0001036)1.76047692
91Decreased electroretinogram (ERG) amplitude (HP:0000654)1.75203081
92Emotional lability (HP:0000712)1.72831892
93Increased intramyocellular lipid droplets (HP:0012240)1.71402329
94Chromosomal breakage induced by crosslinking agents (HP:0003221)1.70703140
95Opisthotonus (HP:0002179)1.70076590
96Tongue fasciculations (HP:0001308)1.69491854
97Hyperglycinemia (HP:0002154)1.69344041
98Aplasia/hypoplasia of the uterus (HP:0008684)1.68181848
99Sclerocornea (HP:0000647)1.66962906
100Constricted visual fields (HP:0001133)1.64649039

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST44.74832033
2VRK23.68839845
3BUB13.41259487
4TRIM283.37090861
5NUAK13.22755434
6TSSK62.90255650
7TIE12.88451471
8TLK12.81911202
9STK392.76908021
10MAP3K122.68643936
11BMPR1B2.68604427
12EIF2AK32.58280678
13NEK12.51958315
14INSRR2.19167249
15WNK42.12917787
16TAF12.09745070
17ZAK2.07967315
18VRK11.92704953
19EIF2AK11.90065029
20GRK11.81802448
21TNIK1.73343518
22NME11.68293773
23PLK31.66501826
24PBK1.39857835
25TGFBR11.36105154
26OXSR11.34661214
27STK38L1.28716105
28ADRBK21.26568605
29DAPK11.20901431
30TAOK31.19000606
31CDC71.18455551
32EIF2AK21.14306388
33PINK11.13552586
34PASK1.08557971
35SRPK11.07834949
36STK161.00051726
37CDK80.99047919
38MAP4K20.98761496
39BCKDK0.97810971
40PHKG10.96241337
41PHKG20.96241337
42SIK30.95323243
43WNK30.94353954
44MYLK0.85085104
45ACVR1B0.84142735
46PLK20.82142288
47MAPKAPK30.81086098
48TXK0.79691964
49CSNK1A1L0.77302834
50STK30.77127842
51PDK20.75563398
52BMPR20.71160289
53MKNK20.69991430
54PLK10.65690931
55CSNK1G30.61631250
56TTK0.60461914
57MAPKAPK50.57228105
58PRKCI0.56788969
59SMG10.56788902
60ALK0.54378400
61GRK50.51857627
62PIK3CG0.51803133
63DYRK20.50689285
64PRKCQ0.50415036
65BCR0.49299693
66MST1R0.49128106
67PRKCG0.47636866
68ATR0.47626078
69CASK0.46884674
70CSNK1G10.46366507
71PLK40.45611555
72AURKB0.43659416
73CDK90.43524783
74MKNK10.43219843
75NME20.42134758
76PTK2B0.39893563
77DAPK30.39840765
78ADRBK10.38599673
79TEC0.38472224
80FGFR10.37787327
81RIPK40.37605807
82CHEK20.37350454
83STK240.37125706
84FRK0.37064229
85CSNK2A20.36391188
86MAP3K40.35543294
87CSNK1G20.32278960
88WEE10.31725750
89CDK70.30969265
90PRKCE0.30232242
91ILK0.29520331
92STK100.29325751
93CCNB10.29279169
94FLT30.28986988
95CSNK2A10.27971538
96MAP2K70.27909266
97ATM0.27856672
98MAP2K60.27044262
99CSNK1A10.25700332
100CHEK10.24503344

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.22100236
2Protein export_Homo sapiens_hsa030603.76059566
3RNA polymerase_Homo sapiens_hsa030203.04792636
4Oxidative phosphorylation_Homo sapiens_hsa001902.93984490
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.81784730
6Parkinsons disease_Homo sapiens_hsa050122.52832906
7One carbon pool by folate_Homo sapiens_hsa006702.45933100
8Mismatch repair_Homo sapiens_hsa034302.28270478
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.23728656
10Homologous recombination_Homo sapiens_hsa034402.14836046
11RNA degradation_Homo sapiens_hsa030182.11483989
12Ribosome_Homo sapiens_hsa030101.98310910
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.94524443
14DNA replication_Homo sapiens_hsa030301.87697050
15Huntingtons disease_Homo sapiens_hsa050161.78045298
16Basal transcription factors_Homo sapiens_hsa030221.77491484
17Pyrimidine metabolism_Homo sapiens_hsa002401.64911491
18RNA transport_Homo sapiens_hsa030131.64359098
19Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.62839818
20Alzheimers disease_Homo sapiens_hsa050101.61182803
21Propanoate metabolism_Homo sapiens_hsa006401.59860349
22Fanconi anemia pathway_Homo sapiens_hsa034601.56429610
23Base excision repair_Homo sapiens_hsa034101.50841543
24Nucleotide excision repair_Homo sapiens_hsa034201.50295111
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.38401877
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.38336697
27Non-homologous end-joining_Homo sapiens_hsa034501.38223292
282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.34530279
29Purine metabolism_Homo sapiens_hsa002301.34342757
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.34310753
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.31414693
32Folate biosynthesis_Homo sapiens_hsa007901.26976490
33Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.20313535
34Vitamin B6 metabolism_Homo sapiens_hsa007501.17279458
35Sulfur metabolism_Homo sapiens_hsa009201.15097761
36Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.13544456
37Steroid biosynthesis_Homo sapiens_hsa001001.11601121
38Phototransduction_Homo sapiens_hsa047441.11016765
39Regulation of autophagy_Homo sapiens_hsa041401.08583587
40Spliceosome_Homo sapiens_hsa030401.07242398
41Selenocompound metabolism_Homo sapiens_hsa004501.02640646
42Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.02499752
43Peroxisome_Homo sapiens_hsa041461.01271693
44Linoleic acid metabolism_Homo sapiens_hsa005911.00289949
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.97325526
46Pyruvate metabolism_Homo sapiens_hsa006200.95248524
47Nitrogen metabolism_Homo sapiens_hsa009100.94738334
48Cardiac muscle contraction_Homo sapiens_hsa042600.91923665
49Butanoate metabolism_Homo sapiens_hsa006500.91321471
50Type I diabetes mellitus_Homo sapiens_hsa049400.90944533
51Collecting duct acid secretion_Homo sapiens_hsa049660.89833085
52Glutathione metabolism_Homo sapiens_hsa004800.87478062
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.86985945
54Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.86029447
55Tryptophan metabolism_Homo sapiens_hsa003800.83175489
56Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.79212753
57Caffeine metabolism_Homo sapiens_hsa002320.78329842
58alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.77950385
59Primary bile acid biosynthesis_Homo sapiens_hsa001200.75532248
60Metabolic pathways_Homo sapiens_hsa011000.74828362
61Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.74597693
62Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.73800397
63Intestinal immune network for IgA production_Homo sapiens_hsa046720.72323140
64Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.71798620
65Asthma_Homo sapiens_hsa053100.68233832
66Primary immunodeficiency_Homo sapiens_hsa053400.67513198
67Allograft rejection_Homo sapiens_hsa053300.65932688
68Biosynthesis of amino acids_Homo sapiens_hsa012300.65726793
69N-Glycan biosynthesis_Homo sapiens_hsa005100.64359372
70Ether lipid metabolism_Homo sapiens_hsa005650.63632533
71Carbon metabolism_Homo sapiens_hsa012000.62500458
72Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.59907480
73Fatty acid elongation_Homo sapiens_hsa000620.54218120
74Rheumatoid arthritis_Homo sapiens_hsa053230.53668888
75Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.50435050
76Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.49181921
77Hematopoietic cell lineage_Homo sapiens_hsa046400.47844538
78Arachidonic acid metabolism_Homo sapiens_hsa005900.44460971
79Olfactory transduction_Homo sapiens_hsa047400.42319927
80Retinol metabolism_Homo sapiens_hsa008300.41982871
81Pentose and glucuronate interconversions_Homo sapiens_hsa000400.40436521
82Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.40403225
83SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40005116
84Epstein-Barr virus infection_Homo sapiens_hsa051690.39884753
85Cell cycle_Homo sapiens_hsa041100.39598942
86Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.37242650
87Arginine and proline metabolism_Homo sapiens_hsa003300.35180350
88Mineral absorption_Homo sapiens_hsa049780.34818643
89Pentose phosphate pathway_Homo sapiens_hsa000300.34420915
90Fat digestion and absorption_Homo sapiens_hsa049750.32161298
91Autoimmune thyroid disease_Homo sapiens_hsa053200.32145317
92Chemical carcinogenesis_Homo sapiens_hsa052040.31060845
93Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.27398981
94Morphine addiction_Homo sapiens_hsa050320.27003268
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.26729059
96Fatty acid degradation_Homo sapiens_hsa000710.26422846
97Serotonergic synapse_Homo sapiens_hsa047260.26277355
98beta-Alanine metabolism_Homo sapiens_hsa004100.21187018
99p53 signaling pathway_Homo sapiens_hsa041150.20742901
100Antigen processing and presentation_Homo sapiens_hsa046120.20405663

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