ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of mitotic sister chromatid separation (GO:1901970)	9.53553714
2	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	9.53553714
3	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	9.53553714
4	negative regulation of Ras GTPase activity (GO:0034261)	8.94233554
5	eosinophil chemotaxis (GO:0048245)	8.88460986
6	negative regulation of T cell receptor signaling pathway (GO:0050860)	8.61037395
7	eosinophil migration (GO:0072677)	8.01903725
8	fucose catabolic process (GO:0019317)	7.88262404
9	L-fucose metabolic process (GO:0042354)	7.88262404
10	L-fucose catabolic process (GO:0042355)	7.88262404
11	regulation of sister chromatid cohesion (GO:0007063)	7.41833732
12	regulation of mononuclear cell migration (GO:0071675)	7.04627329
13	negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)	6.78360060
14	negative regulation of peptidyl-threonine phosphorylation (GO:0010801)	6.61253452
15	ribosomal small subunit assembly (GO:0000028)	6.45915807
16	branch elongation of an epithelium (GO:0060602)	6.38197936
17	vesicle fusion (GO:0006906)	6.34327604
18	positive regulation of chromosome segregation (GO:0051984)	6.13384674
19	negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)	5.85624917
20	coenzyme A biosynthetic process (GO:0015937)	5.81118532
21	autophagic vacuole fusion (GO:0000046)	5.56335678
22	proteasome assembly (GO:0043248)	5.48706746
23	regulation of T cell receptor signaling pathway (GO:0050856)	5.41912404
24	macrophage chemotaxis (GO:0048246)	5.25195048
25	non-recombinational repair (GO:0000726)	5.18447262
26	double-strand break repair via nonhomologous end joining (GO:0006303)	5.18447262
27	organ growth (GO:0035265)	4.94144838
28	protein import into peroxisome matrix (GO:0016558)	4.58583064
29	positive regulation of calcium ion import (GO:0090280)	4.55476963
30	detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)	4.50161711
31	organelle membrane fusion (GO:0090174)	4.44660494
32	axis elongation (GO:0003401)	4.42394900
33	oxidative demethylation (GO:0070989)	4.36773860
34	localization within membrane (GO:0051668)	4.29540412
35	monocyte chemotaxis (GO:0002548)	4.28634078
36	metallo-sulfur cluster assembly (GO:0031163)	4.22350245
37	iron-sulfur cluster assembly (GO:0016226)	4.22350245
38	organelle fusion (GO:0048284)	4.13047634
39	acrosome assembly (GO:0001675)	4.11767963
40	fucosylation (GO:0036065)	4.11404211
41	fucose metabolic process (GO:0006004)	4.07826213
42	peptidyl-lysine dimethylation (GO:0018027)	4.07783819
43	regulation of nitric-oxide synthase biosynthetic process (GO:0051769)	4.06437924
44	detection of chemical stimulus involved in sensory perception of taste (GO:0050912)	3.97380962
45	preassembly of GPI anchor in ER membrane (GO:0016254)	3.96495464
46	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	3.91739218
47	seminiferous tubule development (GO:0072520)	3.89158175
48	negative regulation of GTP catabolic process (GO:0033125)	3.87754835
49	negative regulation of GTPase activity (GO:0034260)	3.87754835
50	negative regulation of circadian rhythm (GO:0042754)	3.81651038
51	pantothenate metabolic process (GO:0015939)	3.81247808
52	regulation of antigen receptor-mediated signaling pathway (GO:0050854)	3.75909487
53	ribonucleoside bisphosphate biosynthetic process (GO:0034030)	3.71828546
54	nucleoside bisphosphate biosynthetic process (GO:0033866)	3.71828546
55	purine nucleoside bisphosphate biosynthetic process (GO:0034033)	3.71828546
56	DNA demethylation (GO:0080111)	3.71307300
57	regulation of autophagic vacuole assembly (GO:2000785)	3.59790947
58	coenzyme A metabolic process (GO:0015936)	3.57374349
59	DNA integration (GO:0015074)	3.52007748
60	regulation of beta-amyloid formation (GO:1902003)	3.51293584
61	establishment of mitotic spindle orientation (GO:0000132)	3.46444506
62	protein targeting to peroxisome (GO:0006625)	3.44838466
63	establishment of protein localization to peroxisome (GO:0072663)	3.44838466
64	protein localization to peroxisome (GO:0072662)	3.44838466
65	single-organism membrane fusion (GO:0044801)	3.43047822
66	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.40521446
67	termination of RNA polymerase III transcription (GO:0006386)	3.40521446
68	positive chemotaxis (GO:0050918)	3.37927467
69	intracellular protein transmembrane import (GO:0044743)	3.33801153
70	telomere maintenance via recombination (GO:0000722)	3.32181095
71	RNA methylation (GO:0001510)	3.27616827
72	ER to Golgi vesicle-mediated transport (GO:0006888)	3.22351316
73	mitochondrial RNA metabolic process (GO:0000959)	3.16115830
74	negative regulation of macroautophagy (GO:0016242)	3.12267253
75	folic acid-containing compound biosynthetic process (GO:0009396)	3.11766674
76	DNA deamination (GO:0045006)	3.10420602
77	regulation of fibroblast growth factor receptor signaling pathway (GO:0040036)	3.09306970
78	establishment of mitotic spindle localization (GO:0040001)	3.06790187
79	peroxisomal transport (GO:0043574)	3.03850284
80	membrane budding (GO:0006900)	3.02104394
81	histone H3-K9 methylation (GO:0051567)	2.99248129
82	DNA dealkylation (GO:0035510)	2.97353646
83	regulation of vacuole organization (GO:0044088)	2.88943642
84	tRNA modification (GO:0006400)	2.87638798
85	regulation of amyloid precursor protein catabolic process (GO:1902991)	2.86828554
86	establishment of spindle orientation (GO:0051294)	2.86005169
87	regulation of cellular amino acid metabolic process (GO:0006521)	2.85582225
88	protein sumoylation (GO:0016925)	2.85443351
89	regulation of stem cell maintenance (GO:2000036)	2.84321951
90	imidazole-containing compound metabolic process (GO:0052803)	2.79983589
91	sodium-independent organic anion transport (GO:0043252)	2.79090878
92	C-terminal protein lipidation (GO:0006501)	2.78975592
93	GPI anchor biosynthetic process (GO:0006506)	2.76668921
94	GPI anchor metabolic process (GO:0006505)	2.73592301
95	mitotic recombination (GO:0006312)	2.71799091
96	regulation of T cell apoptotic process (GO:0070232)	2.69441800
97	lipid particle organization (GO:0034389)	2.67027594
98	RNA modification (GO:0009451)	2.66699150
99	protein prenylation (GO:0018342)	10.4235661
100	prenylation (GO:0097354)	10.4235661

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	8.11330692
2	GATA1_22025678_ChIP-Seq_K562_Human	7.12201404
3	VDR_22108803_ChIP-Seq_LS180_Human	5.62829563
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.30889724
5	NOTCH1_21737748_ChIP-Seq_TLL_Human	3.70948880
6	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.50618513
7	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.03510709
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.86887756
9	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.63708717
10	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.57381174
11	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.53380081
12	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.46239805
13	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.46122924
14	ZNF274_21170338_ChIP-Seq_K562_Hela	2.42656133
15	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.39294229
16	YY1_21170310_ChIP-Seq_MESCs_Mouse	2.36089084
17	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.25219593
18	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.24544135
19	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.17072849
20	AR_21572438_ChIP-Seq_LNCaP_Human	2.10413345
21	IRF1_19129219_ChIP-ChIP_H3396_Human	2.09502747
22	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.02271178
23	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.95583475
24	VDR_23849224_ChIP-Seq_CD4+_Human	1.92735974
25	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.90630499
26	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.85319529
27	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.69044181
28	ELK1_19687146_ChIP-ChIP_HELA_Human	1.54499363
29	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.49376805
30	TAF15_26573619_Chip-Seq_HEK293_Human	1.48490134
31	BCAT_22108803_ChIP-Seq_LS180_Human	1.36894403
32	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.36341467
33	TP53_22573176_ChIP-Seq_HFKS_Human	1.35490861
34	FOXP3_21729870_ChIP-Seq_TREG_Human	1.35456279
35	GBX2_23144817_ChIP-Seq_PC3_Human	1.33386589
36	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.31429960
37	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.22255711
38	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.21124848
39	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.21124848
40	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.20446873
41	RXR_22108803_ChIP-Seq_LS180_Human	1.13092734
42	GABP_19822575_ChIP-Seq_HepG2_Human	1.12108495
43	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.10996391
44	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.10996391
45	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.10917792
46	GATA3_26560356_Chip-Seq_TH1_Human	1.10892269
47	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.09879140
48	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.09620477
49	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.06037841
50	P300_19829295_ChIP-Seq_ESCs_Human	1.01352223
51	DCP1A_22483619_ChIP-Seq_HELA_Human	1.00503975
52	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.99821677
53	ZIC3_20872845_ChIP-ChIP_MESCs_Mouse	0.99504631
54	FUS_26573619_Chip-Seq_HEK293_Human	0.98959888
55	MYC_18358816_ChIP-ChIP_MESCs_Mouse	0.98549054
56	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.98509235
57	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.97438245
58	HTT_18923047_ChIP-ChIP_STHdh_Human	0.96191336
59	IGF1R_20145208_ChIP-Seq_DFB_Human	0.95897916
60	ERG_20517297_ChIP-Seq_VCAP_Human	0.95447648
61	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.95408934
62	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.94278205
63	E2F4_17652178_ChIP-ChIP_JURKAT_Human	0.91874399
64	ZNF263_19887448_ChIP-Seq_K562_Human	0.91706299
65	CREB1_15753290_ChIP-ChIP_HEK293T_Human	0.91542706
66	SOX2_19829295_ChIP-Seq_ESCs_Human	0.91406326
67	NANOG_19829295_ChIP-Seq_ESCs_Human	0.91406326
68	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.91253903
69	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.89998595
70	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	0.89268302
71	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.88618938
72	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.88273833
73	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.88144163
74	AR_20517297_ChIP-Seq_VCAP_Human	0.87317818
75	EWS_26573619_Chip-Seq_HEK293_Human	0.84934246
76	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.83266319
77	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.82404080
78	TCF4_22108803_ChIP-Seq_LS180_Human	0.81291600
79	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	0.80851727
80	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.80767486
81	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.80679812
82	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	0.78869560
83	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	0.77992197
84	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	0.77744488
85	NANOG_20526341_ChIP-Seq_ESCs_Human	0.77720130
86	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	0.77051634
87	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.74960193
88	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.74714296
89	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.71239116
90	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.70816763
91	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.70597941
92	TTF2_22483619_ChIP-Seq_HELA_Human	0.69607941
93	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.69415333
94	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.68579469
95	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.68520168
96	MYC_18940864_ChIP-ChIP_HL60_Human	0.68399829
97	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.68315324
98	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.67799952
99	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.67167894
100	STAT3_1855785_ChIP-Seq_MESCs_Mouse	0.66757730

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000566_synostosis	9.98721154
2	MP0003303_peritoneal_inflammation	6.99666042
3	MP0006082_CNS_inflammation	4.79023543
4	MP0002102_abnormal_ear_morphology	3.25210565
5	MP0002751_abnormal_autonomic_nervous	2.85693362
6	MP0001663_abnormal_digestive_system	2.75474289
7	MP0001664_abnormal_digestion	2.63256823
8	MP0001919_abnormal_reproductive_system	2.58567400
9	MP0000467_abnormal_esophagus_morphology	2.48491733
10	MP0002876_abnormal_thyroid_physiology	2.44338207
11	MP0000383_abnormal_hair_follicle	2.28096691
12	MP0005381_digestive/alimentary_phenotyp	2.00097831
13	MP0005389_reproductive_system_phenotype	1.80005692
14	MP0001764_abnormal_homeostasis	1.63434318
15	MP0008058_abnormal_DNA_repair	1.59733994
16	MP0003880_abnormal_central_pattern	1.58782977
17	MP0003115_abnormal_respiratory_system	1.57182831
18	MP0002163_abnormal_gland_morphology	1.54350841
19	MP0005671_abnormal_response_to	1.51706178
20	MP0005166_decreased_susceptibility_to	1.49228602
21	MP0001293_anophthalmia	1.46203667
22	MP0003937_abnormal_limbs/digits/tail_de	1.44561327
23	MP0008875_abnormal_xenobiotic_pharmacok	1.39542283
24	MP0002837_dystrophic_cardiac_calcinosis	1.39541023
25	MP0010678_abnormal_skin_adnexa	1.36837860
26	MP0001529_abnormal_vocalization	1.31429411
27	MP0001986_abnormal_taste_sensitivity	1.29281809
28	MP0002822_catalepsy	1.28471223
29	MP0002138_abnormal_hepatobiliary_system	1.27740150
30	MP0000372_irregular_coat_pigmentation	1.21748033
31	MP0008877_abnormal_DNA_methylation	1.20494060
32	MP0003763_abnormal_thymus_physiology	1.18485446
33	MP0003195_calcinosis	1.15409550
34	MP0005379_endocrine/exocrine_gland_phen	1.15164487
35	MP0005084_abnormal_gallbladder_morpholo	1.14285583
36	MP0000490_abnormal_crypts_of	1.09968954
37	MP0008872_abnormal_physiological_respon	1.06858628
38	MP0000358_abnormal_cell_content/	1.06585972
39	MP0002019_abnormal_tumor_incidence	1.01945287
40	MP0002736_abnormal_nociception_after	1.00362423
41	MP0001286_abnormal_eye_development	0.96523689
42	MP0000026_abnormal_inner_ear	0.95704127
43	MP0006072_abnormal_retinal_apoptosis	0.94939678
44	MP0005253_abnormal_eye_physiology	0.93347337
45	MP0001915_intracranial_hemorrhage	0.92690938
46	MP0003718_maternal_effect	0.91108637
47	MP0001968_abnormal_touch/_nociception	0.90545280
48	MP0001963_abnormal_hearing_physiology	0.89316050
49	MP0010155_abnormal_intestine_physiology	0.89181860
50	MP0001984_abnormal_olfaction	0.89085691
51	MP0005551_abnormal_eye_electrophysiolog	0.88923620
52	MP0004147_increased_porphyrin_level	0.88090022
53	MP0005645_abnormal_hypothalamus_physiol	0.87367033
54	MP0000534_abnormal_ureter_morphology	0.86531637
55	MP0005332_abnormal_amino_acid	0.85900465
56	MP0005377_hearing/vestibular/ear_phenot	0.85582154
57	MP0003878_abnormal_ear_physiology	0.85582154
58	MP0002184_abnormal_innervation	0.80616073
59	MP0002277_abnormal_respiratory_mucosa	0.76209451
60	MP0009763_increased_sensitivity_to	0.74795708
61	MP0001835_abnormal_antigen_presentation	0.74602625
62	MP0004145_abnormal_muscle_electrophysio	0.74359408
63	MP0002210_abnormal_sex_determination	0.73274382
64	MP0005501_abnormal_skin_physiology	0.72326378
65	MP0002109_abnormal_limb_morphology	0.69652046
66	MP0000428_abnormal_craniofacial_morphol	0.69315525
67	MP0000477_abnormal_intestine_morphology	0.66416880
68	MP0005410_abnormal_fertilization	0.65628326
69	MP0005085_abnormal_gallbladder_physiolo	0.64515728
70	MP0002405_respiratory_system_inflammati	0.63670181
71	MP0009785_altered_susceptibility_to	0.63002883
72	MP0001800_abnormal_humoral_immune	0.61694768
73	MP0003011_delayed_dark_adaptation	0.60993206
74	MP0008789_abnormal_olfactory_epithelium	0.60457477
75	MP0003806_abnormal_nucleotide_metabolis	0.58065202
76	MP0003329_amyloid_beta_deposits	0.57183649
77	MP0008775_abnormal_heart_ventricle	0.57100149
78	MP0001545_abnormal_hematopoietic_system	0.56130191
79	MP0005397_hematopoietic_system_phenotyp	0.56130191
80	MP0003638_abnormal_response/metabolism_	0.55875639
81	MP0001501_abnormal_sleep_pattern	0.54770441
82	MP0005360_urolithiasis	0.54754733
83	MP0002752_abnormal_somatic_nervous	0.52458810
84	MP0002115_abnormal_skeleton_extremities	0.52275893
85	MP0003786_premature_aging	0.51378108
86	MP0004019_abnormal_vitamin_homeostasis	0.50906971
87	MP0006276_abnormal_autonomic_nervous	0.49380671
88	MP0005646_abnormal_pituitary_gland	0.49304541
89	MP0002452_abnormal_antigen_presenting	0.49119275
90	MP0002234_abnormal_pharynx_morphology	0.48298966
91	MP0002272_abnormal_nervous_system	0.48287723
92	MP0000858_altered_metastatic_potential	0.47689113
93	MP0009333_abnormal_splenocyte_physiolog	0.46267384
94	MP0006292_abnormal_olfactory_placode	0.46243113
95	MP0001119_abnormal_female_reproductive	0.46010869
96	MP0004885_abnormal_endolymph	0.45994352
97	MP0005075_abnormal_melanosome_morpholog	0.45754417
98	MP0000470_abnormal_stomach_morphology	0.45511321
99	MP0009745_abnormal_behavioral_response	0.44902342
100	MP0001873_stomach_inflammation	0.44496896

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	8.58098095
2	Duplicated collecting system (HP:0000081)	6.87570725
3	Abnormality of the renal collecting system (HP:0004742)	6.16696064
4	Large for gestational age (HP:0001520)	6.15317370
5	Long foot (HP:0001833)	6.00740515
6	Adactyly (HP:0009776)	5.45366300
7	Hypoplastic pelvis (HP:0008839)	5.28119908
8	Acute lymphatic leukemia (HP:0006721)	5.17181711
9	Abnormality of fatty-acid metabolism (HP:0004359)	4.79400726
10	Dry hair (HP:0011359)	4.41685965
11	Progressive muscle weakness (HP:0003323)	4.39184789
12	Autoamputation (HP:0001218)	4.27297063
13	Brushfield spots (HP:0001088)	4.21024610
14	Ureteral stenosis (HP:0000071)	4.03962841
15	Steatorrhea (HP:0002570)	3.76955348
16	Ureteral obstruction (HP:0006000)	3.70413733
17	Ureteral duplication (HP:0000073)	3.61985586
18	Severe muscular hypotonia (HP:0006829)	3.50757792
19	Hypoplastic nipples (HP:0002557)	3.47590935
20	Pulmonary artery stenosis (HP:0004415)	3.34623452
21	Anhidrosis (HP:0000970)	3.30701172
22	Reduced subcutaneous adipose tissue (HP:0003758)	3.24697920
23	Abnormal auditory evoked potentials (HP:0006958)	3.21393521
24	Broad-based gait (HP:0002136)	3.19067262
25	Menstrual irregularities (HP:0000858)	3.06121420
26	Lactic acidosis (HP:0003128)	2.96180202
27	Fat malabsorption (HP:0002630)	2.92904302
28	Acute necrotizing encephalopathy (HP:0006965)	2.82109543
29	Myoglobinuria (HP:0002913)	2.78389952
30	Rhabdomyolysis (HP:0003201)	2.71079322
31	Sudden death (HP:0001699)	2.62243256
32	Polymicrogyria (HP:0002126)	2.59625619
33	Epiphyseal stippling (HP:0010655)	2.56422505
34	Palmoplantar hyperkeratosis (HP:0000972)	2.55247493
35	Polyneuropathy (HP:0001271)	2.53263065
36	Decreased muscle mass (HP:0003199)	2.53058910
37	Mitochondrial inheritance (HP:0001427)	2.51505460
38	Abnormal mitochondria in muscle tissue (HP:0008316)	2.49796789
39	Chorioretinal coloboma (HP:0000567)	2.49444822
40	Clubbing of toes (HP:0100760)	2.49340412
41	Increased serum lactate (HP:0002151)	2.48597031
42	Acute encephalopathy (HP:0006846)	2.46707150
43	Palmar hyperkeratosis (HP:0010765)	2.46140329
44	Decreased lacrimation (HP:0000633)	2.41729806
45	Increased CSF lactate (HP:0002490)	2.41637301
46	Progressive macrocephaly (HP:0004481)	2.34876827
47	Stomatitis (HP:0010280)	2.33881158
48	Aplasia/hypoplasia of the uterus (HP:0008684)	2.31238820
49	Hepatocellular necrosis (HP:0001404)	2.27999148
50	Abnormality of vision evoked potentials (HP:0000649)	2.26834654
51	Abnormal connection of the cardiac segments (HP:0011545)	2.24635063
52	Abnormal ventriculo-arterial connection (HP:0011563)	2.24635063
53	Transposition of the great arteries (HP:0001669)	2.24635063
54	Exercise intolerance (HP:0003546)	2.20741536
55	Female pseudohermaphroditism (HP:0010458)	2.17074975
56	Wide intermamillary distance (HP:0006610)	2.16271963
57	3-Methylglutaconic aciduria (HP:0003535)	2.10885741
58	Respiratory failure (HP:0002878)	2.09221913
59	Hepatic necrosis (HP:0002605)	2.08135343
60	CNS demyelination (HP:0007305)	2.03957890
61	Increased number of teeth (HP:0011069)	2.03916122
62	Pancreatic cysts (HP:0001737)	1.98706460
63	IgG deficiency (HP:0004315)	1.97008431
64	Plantar hyperkeratosis (HP:0007556)	1.96557868
65	True hermaphroditism (HP:0010459)	1.94296594
66	Broad nasal tip (HP:0000455)	1.93671670
67	Methylmalonic acidemia (HP:0002912)	1.88999894
68	Postnatal microcephaly (HP:0005484)	1.86473198
69	Metabolic acidosis (HP:0001942)	1.86420778
70	Increased IgM level (HP:0003496)	1.84768711
71	Cerebral edema (HP:0002181)	1.83377364
72	Congenital stationary night blindness (HP:0007642)	1.82515294
73	Abnormal epiphyseal ossification (HP:0010656)	1.82424616
74	Widely spaced teeth (HP:0000687)	1.80381053
75	Hypoplastic iliac wings (HP:0002866)	1.78257823
76	Aplasia/Hypoplasia of the nipples (HP:0006709)	1.77166667
77	Renal Fanconi syndrome (HP:0001994)	1.76982985
78	Increased hepatocellular lipid droplets (HP:0006565)	1.72663097
79	Overfolded helix (HP:0000396)	1.72359363
80	Hypoplasia of the uterus (HP:0000013)	1.69893579
81	Large hands (HP:0001176)	1.69058543
82	Pancreatic fibrosis (HP:0100732)	1.69019721
83	Anxiety (HP:0000739)	1.68592605
84	Generalized amyotrophy (HP:0003700)	1.68121906
85	Optic disc pallor (HP:0000543)	1.66302616
86	Hypoproteinemia (HP:0003075)	1.63365538
87	Lipid accumulation in hepatocytes (HP:0006561)	1.63172611
88	Renal cortical cysts (HP:0000803)	1.63090067
89	Hyperammonemia (HP:0001987)	1.62875521
90	Methylmalonic aciduria (HP:0012120)	1.62608843
91	Abnormality of the renal cortex (HP:0011035)	1.61558113
92	Congenital onset (HP:0003577)	1.59177133
93	Primary adrenal insufficiency (HP:0008207)	1.58426088
94	Spastic tetraplegia (HP:0002510)	1.58357766
95	Cerebral hypomyelination (HP:0006808)	1.57340809
96	Abnormality of the line of Schwalbe (HP:0008048)	1.57143038
97	Posterior embryotoxon (HP:0000627)	1.54162058
98	Flat face (HP:0012368)	1.53152735
99	Thickened nuchal skin fold (HP:0000474)	1.49682897
100	Lethargy (HP:0001254)	1.48973416

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MKNK1	6.49668297
2	TAOK2	4.87304611
3	TAOK1	4.60989931
4	MAP3K3	3.42460336
5	MAP3K11	3.24388134
6	MAP2K3	3.18923927
7	JAK3	2.09386583
8	MKNK2	10.7667504
9	SRPK1	1.83365632
10	MAP4K2	1.77750489
11	ABL2	1.70479930
12	DYRK1A	1.59588355
13	VRK2	1.50822965
14	TRIM28	1.26910477
15	TXK	1.17532075
16	MAP3K5	1.11465551
17	TLK1	1.06594880
18	ZAK	1.03066108
19	NUAK1	0.94629741
20	TSSK6	0.93753845
21	ADRBK2	0.91950641
22	VRK1	0.91720699
23	MST4	0.88690816
24	TIE1	0.86476465
25	NEK1	0.80721779
26	BUB1	0.77932501
27	GRK1	0.76434165
28	WNK3	0.70711280
29	CHEK2	0.69788143
30	WNK4	0.68983329
31	BCKDK	0.64389822
32	PRKCQ	0.61281833
33	BCR	0.54597058
34	TAF1	0.51054514
35	MAP3K8	0.49558795
36	FRK	0.49291532
37	MAP3K1	0.48363514
38	KDR	0.47453067
39	OXSR1	0.47390339
40	BMPR1B	0.46023890
41	EIF2AK3	0.45690599
42	PLK3	0.45471528
43	TESK1	0.45256213
44	STK39	0.44147148
45	PLK4	0.35099937
46	INSRR	0.35096267
47	EIF2AK1	0.34870124
48	TNIK	0.34750677
49	PLK2	0.33107899
50	CSNK1G3	0.32864232
51	DYRK2	0.31699224
52	CSNK1A1	0.30001488
53	CSNK1G1	0.29700922
54	DAPK1	0.28075038
55	CSNK1G2	0.27149798
56	EIF2AK2	0.26509283
57	PAK3	0.25050534
58	GRK5	0.21853339
59	TESK2	0.21313307
60	SIK3	0.20846638
61	CSNK1A1L	0.19997510
62	PHKG1	0.19580462
63	PHKG2	0.19580462
64	MAP3K12	0.19261298
65	IGF1R	0.19134195
66	TAOK3	0.18695600
67	PBK	0.18651187
68	ERBB3	0.18338367
69	IKBKB	0.18244031
70	TEC	0.18148374
71	OBSCN	0.17349960
72	MAPK13	0.16612813
73	MYLK	0.16068905
74	CSNK2A1	0.15160942
75	CSNK2A2	0.14823504
76	RPS6KA5	0.14760331
77	MAP2K7	0.11643872
78	PRKCD	0.11625059
79	AURKA	0.11502283
80	MAPKAPK5	0.11409477
81	MAP3K4	0.11190198
82	ABL1	0.10971080
83	PRKCA	0.09439391
84	PINK1	0.09150981
85	MAP4K1	0.08605162
86	GRK7	0.08603589
87	PASK	0.08260433
88	PRKCE	0.07548711
89	NME1	0.07020673
90	LMTK2	0.06613559
91	ITK	0.06603615
92	RPS6KA4	0.06152417
93	LIMK1	0.05833750
94	PRKCB	0.05677256
95	CCNB1	0.05502980
96	IKBKE	0.05268671
97	PRKACA	0.04858347
98	MINK1	0.04641153
99	PRKCG	0.04473489
100	CSNK1E	0.04300913

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	5.11571373
2	Proteasome_Homo sapiens_hsa03050	4.31255828
3	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	4.31020499
4	RNA polymerase_Homo sapiens_hsa03020	3.52290435
5	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.15686884
6	Fatty acid elongation_Homo sapiens_hsa00062	2.37758781
7	Butanoate metabolism_Homo sapiens_hsa00650	2.36765398
8	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.23329383
9	Propanoate metabolism_Homo sapiens_hsa00640	2.12233523
10	One carbon pool by folate_Homo sapiens_hsa00670	2.02164717
11	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.98805945
12	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.87781818
13	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.83874997
14	Oxidative phosphorylation_Homo sapiens_hsa00190	1.82880628
15	Taste transduction_Homo sapiens_hsa04742	1.75133401
16	Protein export_Homo sapiens_hsa03060	1.73649968
17	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.54011042
18	Parkinsons disease_Homo sapiens_hsa05012	1.52949420
19	Asthma_Homo sapiens_hsa05310	1.45885032
20	Phototransduction_Homo sapiens_hsa04744	1.39981736
21	Tryptophan metabolism_Homo sapiens_hsa00380	1.39103627
22	Primary immunodeficiency_Homo sapiens_hsa05340	1.37630497
23	Peroxisome_Homo sapiens_hsa04146	1.33587884
24	beta-Alanine metabolism_Homo sapiens_hsa00410	1.33255867
25	Pyrimidine metabolism_Homo sapiens_hsa00240	1.30700855
26	Allograft rejection_Homo sapiens_hsa05330	1.19731116
27	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.17289458
28	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.16949632
29	Huntingtons disease_Homo sapiens_hsa05016	1.11031727
30	Glycerolipid metabolism_Homo sapiens_hsa00561	1.06086735
31	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.04260477
32	Caffeine metabolism_Homo sapiens_hsa00232	1.02573901
33	Nucleotide excision repair_Homo sapiens_hsa03420	1.01328190
34	RNA transport_Homo sapiens_hsa03013	1.01270891
35	Fatty acid metabolism_Homo sapiens_hsa01212	0.99923955
36	Purine metabolism_Homo sapiens_hsa00230	0.99434740
37	Linoleic acid metabolism_Homo sapiens_hsa00591	0.95107227
38	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.94898082
39	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.94066921
40	Fatty acid degradation_Homo sapiens_hsa00071	0.93831004
41	Lysine degradation_Homo sapiens_hsa00310	0.92822061
42	Type I diabetes mellitus_Homo sapiens_hsa04940	0.89797219
43	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.87510808
44	Basal transcription factors_Homo sapiens_hsa03022	0.85267607
45	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.83842497
46	RNA degradation_Homo sapiens_hsa03018	0.82924420
47	Homologous recombination_Homo sapiens_hsa03440	0.77200354
48	Alzheimers disease_Homo sapiens_hsa05010	0.75493904
49	Viral myocarditis_Homo sapiens_hsa05416	0.75024221
50	Mismatch repair_Homo sapiens_hsa03430	0.73391667
51	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.72798587
52	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.71249997
53	Graft-versus-host disease_Homo sapiens_hsa05332	0.71047811
54	Nitrogen metabolism_Homo sapiens_hsa00910	0.69373727
55	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.69107007
56	Carbon metabolism_Homo sapiens_hsa01200	0.67260621
57	Sulfur metabolism_Homo sapiens_hsa00920	0.67257102
58	Retinol metabolism_Homo sapiens_hsa00830	0.65968818
59	Antigen processing and presentation_Homo sapiens_hsa04612	0.65859029
60	Steroid biosynthesis_Homo sapiens_hsa00100	0.65015756
61	Metabolic pathways_Homo sapiens_hsa01100	0.63668907
62	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.63586915
63	Fat digestion and absorption_Homo sapiens_hsa04975	0.63395143
64	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.62821528
65	DNA replication_Homo sapiens_hsa03030	0.61628337
66	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.61183288
67	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.60988943
68	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.60773816
69	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.59948726
70	Collecting duct acid secretion_Homo sapiens_hsa04966	0.58342895
71	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.57180527
72	Chemical carcinogenesis_Homo sapiens_hsa05204	0.55713089
73	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.55639832
74	Rheumatoid arthritis_Homo sapiens_hsa05323	0.54181469
75	Fanconi anemia pathway_Homo sapiens_hsa03460	0.54120949
76	Renin-angiotensin system_Homo sapiens_hsa04614	0.52138195
77	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.51917079
78	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.51463152
79	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.50086883
80	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.49647499
81	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.49631629
82	Non-homologous end-joining_Homo sapiens_hsa03450	0.49210279
83	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.47959902
84	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.47785274
85	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.47458748
86	Cardiac muscle contraction_Homo sapiens_hsa04260	0.46885228
87	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.46463168
88	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.45800405
89	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.45187956
90	Base excision repair_Homo sapiens_hsa03410	0.39845448
91	Olfactory transduction_Homo sapiens_hsa04740	0.39638274
92	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.39095674
93	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.36465346
94	Ether lipid metabolism_Homo sapiens_hsa00565	0.35794593
95	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.35284031
96	Folate biosynthesis_Homo sapiens_hsa00790	0.34392052
97	Glutathione metabolism_Homo sapiens_hsa00480	0.32898499
98	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.32628239
99	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.32575328
100	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.31350487

GAPDHP21

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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