GAPDHP22

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Arp2/3 complex-mediated actin nucleation (GO:0034314)9.59696005
2regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450918.66948118
3actin nucleation (GO:0045010)8.23308731
4negative regulation of stress fiber assembly (GO:0051497)7.43648657
5DNA deamination (GO:0045006)6.50038552
6activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO5.95628241
7negative regulation of actin filament bundle assembly (GO:0032232)5.69864591
8viral mRNA export from host cell nucleus (GO:0046784)5.46332265
9negative regulation by host of viral transcription (GO:0043922)5.37610714
10cullin deneddylation (GO:0010388)5.24911745
11protoporphyrinogen IX biosynthetic process (GO:0006782)5.22849602
12positive regulation of translational initiation (GO:0045948)4.88663688
13protoporphyrinogen IX metabolic process (GO:0046501)4.56320369
14proteasome assembly (GO:0043248)4.55388035
15execution phase of apoptosis (GO:0097194)4.54197730
16protein deneddylation (GO:0000338)4.45478910
17sequestering of actin monomers (GO:0042989)4.43100540
18negative regulation of translational initiation (GO:0045947)4.41501708
19cytidine metabolic process (GO:0046087)4.30879419
20cytidine catabolic process (GO:0006216)4.30879419
21cytidine deamination (GO:0009972)4.30879419
22protein insertion into membrane (GO:0051205)4.00763566
23negative regulation of telomere maintenance (GO:0032205)3.96118267
24mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.94931873
25positive regulation of natural killer cell mediated immunity (GO:0002717)3.94682389
26positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.87028457
27pyrimidine-containing compound transmembrane transport (GO:0072531)3.73819049
28hormone catabolic process (GO:0042447)3.71948713
29energy coupled proton transport, down electrochemical gradient (GO:0015985)3.68435395
30ATP synthesis coupled proton transport (GO:0015986)3.68435395
31regulation of exit from mitosis (GO:0007096)3.63524067
32piRNA metabolic process (GO:0034587)3.61356529
33positive regulation of lamellipodium assembly (GO:0010592)3.54796135
34purine deoxyribonucleotide catabolic process (GO:0009155)3.41359198
35mature B cell differentiation involved in immune response (GO:0002313)3.41243818
36pyrimidine ribonucleoside catabolic process (GO:0046133)3.38014513
37DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.35440304
38establishment of protein localization to mitochondrial membrane (GO:0090151)3.35153005
39nucleotide transmembrane transport (GO:1901679)3.33659447
40negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.32169110
41deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.29572662
42intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.27927344
43signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.27927344
44rRNA modification (GO:0000154)3.23199303
45modulation by host of symbiont transcription (GO:0052472)3.19639199
46modulation by host of viral transcription (GO:0043921)3.19639199
47regulation of cellular amino acid metabolic process (GO:0006521)3.19330837
48signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.19258487
49signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.19258487
50signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.19258487
51negative regulation of viral transcription (GO:0032897)3.12607432
52protein heterotetramerization (GO:0051290)3.11925574
53negative regulation of glycogen biosynthetic process (GO:0045719)3.09816406
54heme biosynthetic process (GO:0006783)3.09586157
55signal transduction involved in DNA integrity checkpoint (GO:0072401)3.07281745
56signal transduction involved in DNA damage checkpoint (GO:0072422)3.07281745
57tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.02810247
58RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.02810247
59signal transduction involved in cell cycle checkpoint (GO:0072395)3.01093838
60regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.00075999
61modulation of transcription in other organism involved in symbiotic interaction (GO:0052312)2.99389914
62positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.97899193
63Golgi transport vesicle coating (GO:0048200)2.92927305
64COPI coating of Golgi vesicle (GO:0048205)2.92927305
65positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.92309933
66anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.92187905
67ubiquinone biosynthetic process (GO:0006744)2.90160584
68negative regulation of ligase activity (GO:0051352)2.90080367
69negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.90080367
70ubiquinone metabolic process (GO:0006743)2.87663807
71inositol phosphate dephosphorylation (GO:0046855)2.87516418
72phosphorylated carbohydrate dephosphorylation (GO:0046838)2.87516418
73heme metabolic process (GO:0042168)2.86383353
74regulation of natural killer cell mediated immunity (GO:0002715)2.85796285
75regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.85796285
76antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.85363183
77regulation of telomere maintenance via telomerase (GO:0032210)2.85225890
78negative regulation of thymocyte apoptotic process (GO:0070244)2.82465650
79positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.82095861
80response to X-ray (GO:0010165)2.80804619
81positive regulation of actin filament polymerization (GO:0030838)2.78749400
82maturation of 5.8S rRNA (GO:0000460)2.77738914
83regulation of translational termination (GO:0006449)2.77443709
84male meiosis (GO:0007140)2.75320577
85mitotic sister chromatid segregation (GO:0000070)2.70109256
86nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.67888242
87spermatid nucleus differentiation (GO:0007289)2.66638324
88nucleotide transport (GO:0006862)2.65233332
89GPI anchor biosynthetic process (GO:0006506)2.63786499
90positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.63109000
91water-soluble vitamin biosynthetic process (GO:0042364)2.61764454
92regulation of T cell receptor signaling pathway (GO:0050856)2.60302640
93antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.60127243
94protein neddylation (GO:0045116)2.57510154
95negative regulation of gene silencing (GO:0060969)2.52439863
96epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.51711931
97cellular ketone body metabolic process (GO:0046950)2.48344522
98DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.47435138
99antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.44888688
100gonadal mesoderm development (GO:0007506)11.8022357

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.04115168
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.45310485
3ELF1_17652178_ChIP-ChIP_JURKAT_Human4.35312470
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.23543457
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.86772663
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.42431897
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.32610972
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.24989996
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.06554424
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.82367512
11CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.47997696
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.47367749
13SRF_21415370_ChIP-Seq_HL-1_Mouse2.46000933
14RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.38805909
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.38731491
16IRF8_21731497_ChIP-ChIP_J774_Mouse2.29374632
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.16791689
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.11364991
19YY1_21170310_ChIP-Seq_MESCs_Mouse2.07636146
20ETS1_20019798_ChIP-Seq_JURKAT_Human2.00112478
21TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.96559714
22FOXP3_21729870_ChIP-Seq_TREG_Human1.95970936
23PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.92118806
24RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.89346457
25VDR_23849224_ChIP-Seq_CD4+_Human1.87493243
26BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.76781227
27DCP1A_22483619_ChIP-Seq_HELA_Human1.70134708
28EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.69812832
29ELK1_19687146_ChIP-ChIP_HELA_Human1.68186602
30STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.67985078
31IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.63972901
32MYC_18358816_ChIP-ChIP_MESCs_Mouse1.59622264
33MYB_26560356_Chip-Seq_TH2_Human1.57703527
34HOXB4_20404135_ChIP-ChIP_EML_Mouse1.57283546
35SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.55087979
36E2F7_22180533_ChIP-Seq_HELA_Human1.55042719
37EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.53159841
38PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.50797426
39NELFA_20434984_ChIP-Seq_ESCs_Mouse1.50625226
40GABP_19822575_ChIP-Seq_HepG2_Human1.50124337
41MYC_19030024_ChIP-ChIP_MESCs_Mouse1.47792499
42E2F4_17652178_ChIP-ChIP_JURKAT_Human1.46765419
43FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.45645133
44FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.45367697
45FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.43827087
46NOTCH1_21737748_ChIP-Seq_TLL_Human1.42666165
47STAT4_19710469_ChIP-ChIP_TH1__Mouse1.41073861
48STAT6_21828071_ChIP-Seq_BEAS2B_Human1.40455602
49THAP11_20581084_ChIP-Seq_MESCs_Mouse1.40360990
50ERG_20517297_ChIP-Seq_VCAP_Human1.37812964
51PCGF2_27294783_Chip-Seq_NPCs_Mouse1.32426427
52MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.32273600
53AUTS2_25519132_ChIP-Seq_293T-REX_Human1.32263269
54PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32090863
55FOXA1_27270436_Chip-Seq_PROSTATE_Human1.30963600
56FOXA1_25329375_ChIP-Seq_VCAP_Human1.30963600
57GATA3_26560356_Chip-Seq_TH2_Human1.30349512
58EGR1_23403033_ChIP-Seq_LIVER_Mouse1.28926674
59TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28826403
60CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.27705255
61CREB1_15753290_ChIP-ChIP_HEK293T_Human1.27125852
62ELF1_20517297_ChIP-Seq_JURKAT_Human1.25127545
63MYC_18940864_ChIP-ChIP_HL60_Human1.20980848
64ZNF274_21170338_ChIP-Seq_K562_Hela1.20490782
65YY1_22570637_ChIP-Seq_MALME-3M_Human1.19525726
66NANOG_20526341_ChIP-Seq_ESCs_Human1.17704341
67CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.16893213
68MYC_19829295_ChIP-Seq_ESCs_Human1.15672141
69VDR_22108803_ChIP-Seq_LS180_Human1.11772657
70TP53_22573176_ChIP-Seq_HFKS_Human1.11360937
71AR_20517297_ChIP-Seq_VCAP_Human1.10418972
72GATA3_21867929_ChIP-Seq_TH1_Mouse1.10277742
73KDM5A_27292631_Chip-Seq_BREAST_Human1.09411857
74TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.07744600
75P300_27268052_Chip-Seq_Bcells_Human1.07680170
76SPI1_23547873_ChIP-Seq_NB4_Human1.07492056
77FOXM1_23109430_ChIP-Seq_U2OS_Human1.07491527
78TDRD3_21172665_ChIP-Seq_MCF-7_Human1.07390250
79MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.05565119
80MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.04744657
81SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.04490257
82FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03918592
83OCT4_20526341_ChIP-Seq_ESCs_Human1.03566623
84NCOR_22424771_ChIP-Seq_293T_Human1.03110287
85SPI1_20517297_ChIP-Seq_HL60_Human1.02858919
86HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.02631391
87E2F1_18555785_ChIP-Seq_MESCs_Mouse1.02531419
88EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.02177720
89GATA3_27048872_Chip-Seq_THYMUS_Human1.01292759
90ZNF263_19887448_ChIP-Seq_K562_Human1.00612893
91P53_21459846_ChIP-Seq_SAOS-2_Human1.00338412
92HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.00222010
93HOXB7_26014856_ChIP-Seq_BT474_Human0.99192583
94CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.97259434
95PCGF2_27294783_Chip-Seq_ESCs_Mouse0.96047921
96ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.94751715
97PHF8_20622854_ChIP-Seq_HELA_Human0.93666757
98MYC_18555785_ChIP-Seq_MESCs_Mouse0.92996414
99FLI1_27457419_Chip-Seq_LIVER_Mouse0.92969413
100EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.91021579

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004147_increased_porphyrin_level8.28590217
2MP0006054_spinal_hemorrhage3.67649376
3MP0002166_altered_tumor_susceptibility3.17873924
4MP0003806_abnormal_nucleotide_metabolis2.81797820
5MP0002234_abnormal_pharynx_morphology2.31991798
6MP0002736_abnormal_nociception_after2.25353782
7MP0009333_abnormal_splenocyte_physiolog2.24968582
8MP0002006_tumorigenesis2.24896668
9MP0001968_abnormal_touch/_nociception2.16974497
10MP0003195_calcinosis2.02746334
11MP0002138_abnormal_hepatobiliary_system2.01739945
12MP0010386_abnormal_urinary_bladder2.01456240
13MP0004145_abnormal_muscle_electrophysio1.97249116
14MP0009785_altered_susceptibility_to1.95516740
15MP0004957_abnormal_blastocyst_morpholog1.91051440
16MP0005083_abnormal_biliary_tract1.90166484
17MP0008007_abnormal_cellular_replicative1.84751725
18MP0001835_abnormal_antigen_presentation1.83964929
19MP0002009_preneoplasia1.72083910
20MP0003763_abnormal_thymus_physiology1.68098514
21MP0002102_abnormal_ear_morphology1.67859377
22MP0003693_abnormal_embryo_hatching1.66730196
23MP0006292_abnormal_olfactory_placode1.63920555
24MP0002148_abnormal_hypersensitivity_rea1.63768884
25MP0005671_abnormal_response_to1.57840734
26MP0008877_abnormal_DNA_methylation1.51626806
27MP0001800_abnormal_humoral_immune1.50482936
28MP0003878_abnormal_ear_physiology1.47999311
29MP0005377_hearing/vestibular/ear_phenot1.47999311
30MP0005084_abnormal_gallbladder_morpholo1.45887508
31MP0006036_abnormal_mitochondrial_physio1.45278029
32MP0001879_abnormal_lymphatic_vessel1.38203957
33MP0003656_abnormal_erythrocyte_physiolo1.35483805
34MP0005367_renal/urinary_system_phenotyp1.34918077
35MP0000516_abnormal_urinary_system1.34918077
36MP0001790_abnormal_immune_system1.34797104
37MP0005387_immune_system_phenotype1.34797104
38MP0005636_abnormal_mineral_homeostasis1.33362613
39MP0003252_abnormal_bile_duct1.32595416
40MP0003866_abnormal_defecation1.32022389
41MP0005167_abnormal_blood-brain_barrier1.30984318
42MP0002837_dystrophic_cardiac_calcinosis1.30765604
43MP0002653_abnormal_ependyma_morphology1.29836296
44MP0002928_abnormal_bile_duct1.29067364
45MP0002420_abnormal_adaptive_immunity1.19921969
46MP0003045_fibrosis1.19480112
47MP0000015_abnormal_ear_pigmentation1.17774392
48MP0001485_abnormal_pinna_reflex1.16974254
49MP0003786_premature_aging1.16942958
50MP0004885_abnormal_endolymph1.16562807
51MP0002452_abnormal_antigen_presenting1.16127594
52MP0003950_abnormal_plasma_membrane1.15945957
53MP0003718_maternal_effect1.15916021
54MP0001819_abnormal_immune_cell1.14520413
55MP0002723_abnormal_immune_serum1.13991262
56MP0004233_abnormal_muscle_weight1.12363457
57MP0003787_abnormal_imprinting1.08401579
58MP0002398_abnormal_bone_marrow1.04674563
59MP0006138_congestive_heart_failure1.03979114
60MP0002132_abnormal_respiratory_system1.03750023
61MP0003186_abnormal_redox_activity0.97342090
62MP0000689_abnormal_spleen_morphology0.97337825
63MP0004142_abnormal_muscle_tone0.97328307
64MP0003011_delayed_dark_adaptation0.95552580
65MP0005025_abnormal_response_to0.93300995
66MP0005058_abnormal_lysosome_morphology0.92817997
67MP0008932_abnormal_embryonic_tissue0.92513477
68MP0005000_abnormal_immune_tolerance0.92497872
69MP0003111_abnormal_nucleus_morphology0.90795466
70MP0009764_decreased_sensitivity_to0.90713296
71MP0001542_abnormal_bone_strength0.88724226
72MP0002160_abnormal_reproductive_system0.87358518
73MP0003567_abnormal_fetal_cardiomyocyte0.86881513
74MP0000538_abnormal_urinary_bladder0.85824508
75MP0009697_abnormal_copulation0.85138775
76MP0005395_other_phenotype0.83625506
77MP0004215_abnormal_myocardial_fiber0.83566060
78MP0005389_reproductive_system_phenotype0.82995305
79MP0005410_abnormal_fertilization0.82644505
80MP0002722_abnormal_immune_system0.80201695
81MP0000703_abnormal_thymus_morphology0.79622094
82MP0000749_muscle_degeneration0.79096640
83MP0001845_abnormal_inflammatory_respons0.78844296
84MP0000371_diluted_coat_color0.77902361
85MP0008469_abnormal_protein_level0.77745296
86MP0001929_abnormal_gametogenesis0.77570796
87MP0009765_abnormal_xenobiotic_induced0.76436642
88MP0005253_abnormal_eye_physiology0.75591107
89MP0000678_abnormal_parathyroid_gland0.75226151
90MP0003436_decreased_susceptibility_to0.74741048
91MP0002429_abnormal_blood_cell0.74478951
92MP0001986_abnormal_taste_sensitivity0.73815208
93MP0005464_abnormal_platelet_physiology0.73595513
94MP0001764_abnormal_homeostasis0.72783747
95MP0000716_abnormal_immune_system0.70451706
96MP0004036_abnormal_muscle_relaxation0.69781239
97MP0002168_other_aberrant_phenotype0.68188361
98MP0003077_abnormal_cell_cycle0.68154867
99MP0000685_abnormal_immune_system0.67689616
100MP0003943_abnormal_hepatobiliary_system0.67461284

Predicted human phenotypes

RankGene SetZ-score
1Increased IgM level (HP:0003496)6.37853461
2Abolished electroretinogram (ERG) (HP:0000550)5.00956912
3Cerebral hypomyelination (HP:0006808)4.19054354
4Abnormality of B cell number (HP:0010975)4.18234490
5B lymphocytopenia (HP:0010976)4.03443205
63-Methylglutaconic aciduria (HP:0003535)3.81536152
7Pancytopenia (HP:0001876)3.78523739
8IgG deficiency (HP:0004315)3.68474162
9Acute hepatic failure (HP:0006554)3.61767218
10Aplastic anemia (HP:0001915)3.36893809
11Hypophosphatemic rickets (HP:0004912)3.19506907
12Renal Fanconi syndrome (HP:0001994)3.09611854
13Type I transferrin isoform profile (HP:0003642)3.07935738
14Generalized aminoaciduria (HP:0002909)3.03471721
15Menstrual irregularities (HP:0000858)2.93666211
16Decreased lacrimation (HP:0000633)2.89563805
17High anterior hairline (HP:0009890)2.86665424
18Abnormality of the heme biosynthetic pathway (HP:0010472)2.86438629
19Encephalitis (HP:0002383)2.86361377
20IgM deficiency (HP:0002850)2.85916923
21Attenuation of retinal blood vessels (HP:0007843)2.84705336
22Pancreatic cysts (HP:0001737)2.81127778
23Vacuolated lymphocytes (HP:0001922)2.80061137
24Abnormality of the renal cortex (HP:0011035)2.79669931
25Chronic diarrhea (HP:0002028)2.69356372
26Delusions (HP:0000746)2.68619039
27Pancreatic fibrosis (HP:0100732)2.59409312
28Elevated erythrocyte sedimentation rate (HP:0003565)2.57584077
29Broad face (HP:0000283)2.54359361
30Abnormal drinking behavior (HP:0030082)2.53798397
31Polydipsia (HP:0001959)2.53798397
32Hypoglycemic seizures (HP:0002173)2.53255760
33Premature ovarian failure (HP:0008209)2.53193013
34Abnormality of fatty-acid metabolism (HP:0004359)2.52340886
35Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.51392570
36Abnormality of alanine metabolism (HP:0010916)2.51392570
37Hyperalaninemia (HP:0003348)2.51392570
38Long nose (HP:0003189)2.50635965
39Bony spicule pigmentary retinopathy (HP:0007737)2.46708138
40Abnormality of the columella (HP:0009929)2.46209315
41Hyperlipoproteinemia (HP:0010980)2.42263685
42Supernumerary spleens (HP:0009799)2.41473333
43Hypoplastic pelvis (HP:0008839)2.40687265
44Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.39400474
45Decreased activity of mitochondrial respiratory chain (HP:0008972)2.39400474
46Bile duct proliferation (HP:0001408)2.38770831
47Abnormal biliary tract physiology (HP:0012439)2.38770831
48CNS hypomyelination (HP:0003429)2.36748099
49Abnormal number of erythroid precursors (HP:0012131)2.32917216
50Abnormality of dental color (HP:0011073)2.30262519
51Pigmentary retinal degeneration (HP:0001146)2.30029609
52Hypoproteinemia (HP:0003075)2.24209604
53Abnormality of urine glucose concentration (HP:0011016)2.22626833
54Glycosuria (HP:0003076)2.22626833
55Amaurosis fugax (HP:0100576)2.21943758
56Autoimmune hemolytic anemia (HP:0001890)2.21575651
57CNS demyelination (HP:0007305)2.18978815
58Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.18736915
59Chest pain (HP:0100749)2.18230683
60True hermaphroditism (HP:0010459)2.18111146
61Hypergammaglobulinemia (HP:0010702)2.16704621
62Renal cortical cysts (HP:0000803)2.15509159
63Mild short stature (HP:0003502)2.14453447
64Hepatic necrosis (HP:0002605)2.14069774
65Aplasia/Hypoplasia of the spleen (HP:0010451)2.10603760
66Asplenia (HP:0001746)2.09156512
67Autoimmune thrombocytopenia (HP:0001973)2.07530902
68Adrenal hypoplasia (HP:0000835)2.07252078
69Horseshoe kidney (HP:0000085)2.05620773
70Decreased electroretinogram (ERG) amplitude (HP:0000654)2.03508439
71Spontaneous abortion (HP:0005268)2.03469476
72Abnormality of the prostate (HP:0008775)2.03381461
73Polyuria (HP:0000103)2.01791985
74Facial shape deformation (HP:0011334)2.01182902
75Potter facies (HP:0002009)2.01182902
76Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.01142918
77Degeneration of the lateral corticospinal tracts (HP:0002314)2.01142918
78Eosinophilia (HP:0001880)2.00933789
79Lymphoma (HP:0002665)2.00789760
80Mesangial abnormality (HP:0001966)1.98532042
81Hypoplasia of the uterus (HP:0000013)1.97750115
82Increased intramyocellular lipid droplets (HP:0012240)1.96994925
83Cystic liver disease (HP:0006706)1.95727841
84Late onset (HP:0003584)1.95615582
85Tongue fasciculations (HP:0001308)1.94480856
86Recurrent bronchitis (HP:0002837)1.93867782
87Dry hair (HP:0011359)1.92069275
88Alacrima (HP:0000522)1.91194640
89Insulin-resistant diabetes mellitus (HP:0000831)1.88820951
90Severe visual impairment (HP:0001141)1.88360850
91Chronic sinusitis (HP:0011109)1.87949657
92Abnormal tarsal ossification (HP:0008369)1.87133598
93Parakeratosis (HP:0001036)1.86430978
94Prostate neoplasm (HP:0100787)1.83753745
95Abnormality of cells of the erythroid lineage (HP:0012130)1.83651718
96Decreased central vision (HP:0007663)1.82641067
97Genetic anticipation (HP:0003743)1.82382218
98Colon cancer (HP:0003003)1.82110225
99Increased serum lactate (HP:0002151)1.82051343
100Abnormality of the anterior horn cell (HP:0006802)1.81219371

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB17.04369180
2MAP3K125.83274184
3TESK24.77146460
4TIE14.56061231
5VRK23.27155434
6KDR3.22898972
7BLK2.62601261
8TESK12.62216069
9WNK42.34068568
10EIF2AK12.06468428
11MAP3K101.83222604
12SCYL21.68347875
13LIMK11.56200318
14STK391.54820882
15GRK11.54509022
16BCKDK1.42515201
17MAP3K131.41464396
18CSNK1G31.38309054
19MYLK1.31331928
20RPS6KA41.29582959
21FES1.26285546
22CSNK1A1L1.26216564
23TLK11.25665363
24ADRBK21.23953091
25TGFBR21.18763109
26TAF11.08442229
27NEK21.08232726
28MAP4K11.05963635
29PAK41.05206685
30PLK21.05193856
31ITK1.02037815
32MAP3K50.97535375
33CSNK1G10.97206304
34TEC0.88590248
35CSNK1G20.88272965
36RIPK40.87322790
37VRK10.85523654
38MST40.83589901
39GRK50.81125011
40INSRR0.79480537
41OXSR10.78201335
42WEE10.74921519
43SRPK10.74102060
44MAP3K110.72992192
45MAPKAPK50.72709120
46CSK0.72708407
47STK100.72070388
48PIK3CG0.71808754
49TXK0.70733859
50BMPR1B0.69410174
51SMG10.68810059
52MAPKAPK30.67057144
53STK38L0.62743197
54TAOK30.62314692
55NUAK10.61788118
56FER0.61526044
57TRPM70.61371498
58BRSK10.59274284
59NEK10.57408844
60DAPK10.54295283
61ATR0.54005860
62BRSK20.52442591
63SYK0.47740485
64GRK70.44381584
65PLK40.43780397
66PIK3CA0.41823331
67CSNK1A10.39233265
68EPHA40.38943530
69TGFBR10.37790424
70MAP3K70.36449991
71EIF2AK30.35899452
72JAK30.35418029
73FLT30.34795037
74MAPKAPK20.34309458
75ILK0.33667561
76MAP3K30.32146239
77SIK30.31269667
78GSK3A0.31101192
79PRKCQ0.30630021
80MAPK110.30080421
81BMPR20.29560260
82TRIM280.29465788
83FRK0.28066715
84PLK30.27644244
85CAMKK20.27576032
86ERBB20.26989229
87CSNK2A10.26580043
88LYN0.25908133
89RPS6KA50.25722404
90DYRK20.24687196
91PTK2B0.24510401
92OBSCN0.23776220
93IKBKB0.23623873
94LCK0.22323892
95AURKB0.20192305
96PAK10.19966783
97CSF1R0.18613259
98TYRO30.17152091
99TSSK60.16741283
100KIT0.15462303

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.46525950
2Protein export_Homo sapiens_hsa030604.27015740
3RNA polymerase_Homo sapiens_hsa030203.15428624
4Primary immunodeficiency_Homo sapiens_hsa053403.10796070
5Oxidative phosphorylation_Homo sapiens_hsa001902.36313012
6Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.33841114
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.21086908
8Parkinsons disease_Homo sapiens_hsa050122.17291899
9Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.10368390
10Alzheimers disease_Homo sapiens_hsa050102.08594084
11One carbon pool by folate_Homo sapiens_hsa006702.06039255
12Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050142.05363225
13Antigen processing and presentation_Homo sapiens_hsa046122.04223489
14Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.96983600
15Allograft rejection_Homo sapiens_hsa053301.83754545
16Autoimmune thyroid disease_Homo sapiens_hsa053201.81354069
17Graft-versus-host disease_Homo sapiens_hsa053321.77547264
18Intestinal immune network for IgA production_Homo sapiens_hsa046721.74486972
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.73734001
20Viral myocarditis_Homo sapiens_hsa054161.65631641
21Huntingtons disease_Homo sapiens_hsa050161.60485425
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.60077439
232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.59602909
24Shigellosis_Homo sapiens_hsa051311.57468406
25Type I diabetes mellitus_Homo sapiens_hsa049401.54516366
26RNA transport_Homo sapiens_hsa030131.49399712
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.42485413
28Prion diseases_Homo sapiens_hsa050201.36641953
29Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.36377218
30RNA degradation_Homo sapiens_hsa030181.33099566
31Arachidonic acid metabolism_Homo sapiens_hsa005901.32986774
32Asthma_Homo sapiens_hsa053101.25255845
33Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.23747480
34Steroid biosynthesis_Homo sapiens_hsa001001.18551903
35N-Glycan biosynthesis_Homo sapiens_hsa005101.11911405
36Peroxisome_Homo sapiens_hsa041461.08245689
37Pyrimidine metabolism_Homo sapiens_hsa002401.04133260
38Non-homologous end-joining_Homo sapiens_hsa034501.02743005
39Epstein-Barr virus infection_Homo sapiens_hsa051691.02286813
40Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.00579797
41Hematopoietic cell lineage_Homo sapiens_hsa046400.97425746
42Salmonella infection_Homo sapiens_hsa051320.88310098
43Glutathione metabolism_Homo sapiens_hsa004800.87252753
44Measles_Homo sapiens_hsa051620.84568414
45Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.84271877
46NF-kappa B signaling pathway_Homo sapiens_hsa040640.82686659
47Purine metabolism_Homo sapiens_hsa002300.80952669
48Fatty acid elongation_Homo sapiens_hsa000620.80179762
49Rheumatoid arthritis_Homo sapiens_hsa053230.76948225
50Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.76548395
51Selenocompound metabolism_Homo sapiens_hsa004500.75938148
52Cardiac muscle contraction_Homo sapiens_hsa042600.74612188
53Pyruvate metabolism_Homo sapiens_hsa006200.71658127
54Steroid hormone biosynthesis_Homo sapiens_hsa001400.71154193
55Drug metabolism - other enzymes_Homo sapiens_hsa009830.71142236
56Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69510466
57Mineral absorption_Homo sapiens_hsa049780.69142027
58Homologous recombination_Homo sapiens_hsa034400.67925721
59Basal transcription factors_Homo sapiens_hsa030220.64915007
60Staphylococcus aureus infection_Homo sapiens_hsa051500.64667061
61Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.64037014
62Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.62569995
63Nitrogen metabolism_Homo sapiens_hsa009100.60818341
64Butanoate metabolism_Homo sapiens_hsa006500.60680209
65Legionellosis_Homo sapiens_hsa051340.58652146
66alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.58395658
67Fanconi anemia pathway_Homo sapiens_hsa034600.58154340
68T cell receptor signaling pathway_Homo sapiens_hsa046600.56773598
69Spliceosome_Homo sapiens_hsa030400.53905153
70Endocytosis_Homo sapiens_hsa041440.53429806
71Nucleotide excision repair_Homo sapiens_hsa034200.53125281
72Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52198897
73Retinol metabolism_Homo sapiens_hsa008300.52115525
74Metabolic pathways_Homo sapiens_hsa011000.51220143
75Apoptosis_Homo sapiens_hsa042100.49045930
76Linoleic acid metabolism_Homo sapiens_hsa005910.48262432
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.47569167
78Fatty acid degradation_Homo sapiens_hsa000710.45602657
79Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44874056
80Renin-angiotensin system_Homo sapiens_hsa046140.44070480
81Pentose and glucuronate interconversions_Homo sapiens_hsa000400.42554518
82Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.42446925
83Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.42413105
84Fatty acid biosynthesis_Homo sapiens_hsa000610.40522151
85Herpes simplex infection_Homo sapiens_hsa051680.39774543
86Biosynthesis of amino acids_Homo sapiens_hsa012300.39601349
87Propanoate metabolism_Homo sapiens_hsa006400.37601610
88Vitamin digestion and absorption_Homo sapiens_hsa049770.36176356
89Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.35278139
90Tyrosine metabolism_Homo sapiens_hsa003500.34653334
91Chemical carcinogenesis_Homo sapiens_hsa052040.32496970
92Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.32368320
93DNA replication_Homo sapiens_hsa030300.31620252
94Tryptophan metabolism_Homo sapiens_hsa003800.31595337
95Systemic lupus erythematosus_Homo sapiens_hsa053220.30114285
96Maturity onset diabetes of the young_Homo sapiens_hsa049500.29060033
97Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.28671754
98Fatty acid metabolism_Homo sapiens_hsa012120.28545301
99Phototransduction_Homo sapiens_hsa047440.28333642
100Ribosome_Homo sapiens_hsa030100.27684068

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