ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	5.12257794
2	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	5.12257794
3	DNA deamination (GO:0045006)	5.09122228
4	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.88944882
5	protein neddylation (GO:0045116)	4.80128254
6	retinal cone cell development (GO:0046549)	4.64444787
7	water-soluble vitamin biosynthetic process (GO:0042364)	4.50719307
8	ATP synthesis coupled proton transport (GO:0015986)	4.38945520
9	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.38945520
10	postsynaptic membrane organization (GO:0001941)	4.07671394
11	chaperone-mediated protein transport (GO:0072321)	3.99117755
12	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.83249535
13	ribosomal small subunit assembly (GO:0000028)	3.76801793
14	protein complex biogenesis (GO:0070271)	3.76596160
15	synaptic transmission, cholinergic (GO:0007271)	3.68146497
16	rRNA modification (GO:0000154)	3.54791035
17	mitochondrial respiratory chain complex assembly (GO:0033108)	3.54686980
18	behavioral response to nicotine (GO:0035095)	3.53346159
19	axoneme assembly (GO:0035082)	3.52049219
20	maturation of SSU-rRNA (GO:0030490)	3.48995455
21	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.48181745
22	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.47315098
23	intracellular protein transmembrane import (GO:0044743)	3.47072336
24	rRNA methylation (GO:0031167)	3.41517707
25	signal peptide processing (GO:0006465)	3.38437405
26	lysine catabolic process (GO:0006554)	3.35668086
27	lysine metabolic process (GO:0006553)	3.35668086
28	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.34091469
29	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.34091469
30	NADH dehydrogenase complex assembly (GO:0010257)	3.34091469
31	xenobiotic catabolic process (GO:0042178)	3.28540490
32	nonmotile primary cilium assembly (GO:0035058)	3.27554793
33	response to folic acid (GO:0051593)	3.26369674
34	protein K6-linked ubiquitination (GO:0085020)	3.25635100
35	respiratory electron transport chain (GO:0022904)	3.23568964
36	proteasome assembly (GO:0043248)	3.21448790
37	electron transport chain (GO:0022900)	3.20928377
38	positive regulation of prostaglandin secretion (GO:0032308)	3.19301706
39	respiratory chain complex IV assembly (GO:0008535)	3.16070106
40	epithelial cilium movement (GO:0003351)	3.14303940
41	alkaloid metabolic process (GO:0009820)	3.13392026
42	neuronal action potential propagation (GO:0019227)	3.07046091
43	ATP biosynthetic process (GO:0006754)	3.02899627
44	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.02870359
45	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.02087810
46	thalamus development (GO:0021794)	3.01631783
47	auditory receptor cell differentiation (GO:0042491)	3.00990930
48	coenzyme catabolic process (GO:0009109)	3.00695374
49	regulation of cilium movement (GO:0003352)	3.00393187
50	cytochrome complex assembly (GO:0017004)	2.97550227
51	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.96084502
52	tRNA processing (GO:0008033)	2.92550172
53	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.91419865
54	replication fork processing (GO:0031297)	2.89185571
55	rRNA catabolic process (GO:0016075)	2.88889562
56	hydrogen ion transmembrane transport (GO:1902600)	2.84824514
57	positive regulation of fatty acid transport (GO:2000193)	2.83764329
58	protein-cofactor linkage (GO:0018065)	2.82027824
59	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.80506978
60	proton transport (GO:0015992)	2.79990914
61	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.77371893
62	cellular response to interferon-beta (GO:0035458)	2.76725123
63	L-serine metabolic process (GO:0006563)	2.76669675
64	negative regulation of complement activation (GO:0045916)	2.75904612
65	hydrogen transport (GO:0006818)	2.74265610
66	regulation of microtubule-based movement (GO:0060632)	2.74222400
67	somite development (GO:0061053)	2.73246440
68	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	2.72879955
69	viral transcription (GO:0019083)	2.71020037
70	tRNA metabolic process (GO:0006399)	2.68599778
71	piRNA metabolic process (GO:0034587)	2.67425980
72	translational termination (GO:0006415)	2.65647871
73	retinal ganglion cell axon guidance (GO:0031290)	2.65463147
74	adaptation of signaling pathway (GO:0023058)	2.65326178
75	nucleotide transmembrane transport (GO:1901679)	2.65274405
76	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.64253722
77	regulation of cellular amino acid metabolic process (GO:0006521)	2.61149685
78	tetrahydrofolate metabolic process (GO:0046653)	2.61048963
79	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.60826666
80	cotranslational protein targeting to membrane (GO:0006613)	2.60396139
81	mechanosensory behavior (GO:0007638)	2.60072161
82	positive regulation of T cell apoptotic process (GO:0070234)	2.59114736
83	protein targeting to ER (GO:0045047)	2.58441431
84	intracellular protein transmembrane transport (GO:0065002)	2.57793451
85	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.56199340
86	ribosomal small subunit biogenesis (GO:0042274)	2.55917743
87	response to pheromone (GO:0019236)	2.55435864
88	GTP biosynthetic process (GO:0006183)	2.55067286
89	negative regulation of multicellular organism growth (GO:0040015)	2.54274238
90	photoreceptor cell maintenance (GO:0045494)	2.53758104
91	cullin deneddylation (GO:0010388)	2.52987884
92	DNA strand renaturation (GO:0000733)	2.52689107
93	protein heterotetramerization (GO:0051290)	2.52282853
94	intraciliary transport (GO:0042073)	2.52218335
95	translational elongation (GO:0006414)	2.51916963
96	serine family amino acid catabolic process (GO:0009071)	2.51336769
97	protein localization to endoplasmic reticulum (GO:0070972)	2.50957636
98	preassembly of GPI anchor in ER membrane (GO:0016254)	2.50046211
99	cellular component biogenesis (GO:0044085)	2.49916936
100	cellular ketone body metabolic process (GO:0046950)	2.49286345

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	5.06944947
2	EZH2_22144423_ChIP-Seq_EOC_Human	4.39939906
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.21482446
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.59801069
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.11953330
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.01491707
7	VDR_22108803_ChIP-Seq_LS180_Human	2.87360419
8	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.86087053
9	ZNF274_21170338_ChIP-Seq_K562_Hela	2.50834881
10	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.46926652
11	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.12368252
12	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.11992373
13	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.09128376
14	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.08168151
15	ELK1_19687146_ChIP-ChIP_HELA_Human	1.97268634
16	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.93384744
17	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.83331855
18	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.79901207
19	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.79477119
20	VDR_23849224_ChIP-Seq_CD4+_Human	1.75395950
21	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.73525714
22	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.70172188
23	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.58221994
24	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.57168480
25	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.56236502
26	IRF1_19129219_ChIP-ChIP_H3396_Human	1.55893346
27	MYC_18940864_ChIP-ChIP_HL60_Human	1.55630598
28	EWS_26573619_Chip-Seq_HEK293_Human	1.53510825
29	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.53457830
30	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.52136151
31	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.51703193
32	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.49521330
33	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.49521330
34	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.48020078
35	FUS_26573619_Chip-Seq_HEK293_Human	1.45430584
36	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.44813503
37	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.44187106
38	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.43345949
39	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.41340493
40	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.40798411
41	FOXP3_21729870_ChIP-Seq_TREG_Human	1.40327702
42	TTF2_22483619_ChIP-Seq_HELA_Human	1.37257882
43	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.37184991
44	P300_19829295_ChIP-Seq_ESCs_Human	1.36027892
45	TAF15_26573619_Chip-Seq_HEK293_Human	1.35034340
46	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.34834730
47	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.33878788
48	GBX2_23144817_ChIP-Seq_PC3_Human	1.32546478
49	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.32376708
50	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.26448325
51	TP53_22573176_ChIP-Seq_HFKS_Human	1.26355561
52	TAF2_19829295_ChIP-Seq_ESCs_Human	1.25898313
53	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.24233377
54	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.24062456
55	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.19437247
56	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.19103713
57	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.18065023
58	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.18016649
59	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.16824842
60	NCOR_22424771_ChIP-Seq_293T_Human	1.16123162
61	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.15762411
62	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.13883930
63	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.10356641
64	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.09643200
65	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.09600647
66	SOX2_19829295_ChIP-Seq_ESCs_Human	1.08099067
67	NANOG_19829295_ChIP-Seq_ESCs_Human	1.08099067
68	REST_21632747_ChIP-Seq_MESCs_Mouse	1.07401803
69	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.04862189
70	GABP_19822575_ChIP-Seq_HepG2_Human	1.04208535
71	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.03022335
72	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.03022335
73	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.00603289
74	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.99383503
75	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.98804601
76	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.98505115
77	TCF4_22108803_ChIP-Seq_LS180_Human	0.97034929
78	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.96537881
79	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	0.93396554
80	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.93163067
81	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.91486441
82	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.91093616
83	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.89385343
84	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.89336409
85	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.88904433
86	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.88370905
87	NANOG_20526341_ChIP-Seq_ESCs_Human	0.88174423
88	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.86888521
89	MYC_19829295_ChIP-Seq_ESCs_Human	0.86683406
90	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	0.86149808
91	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.86083221
92	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.85407833
93	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.85249500
94	RNF2_27304074_Chip-Seq_NSC_Mouse	0.84816620
95	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.84693545
96	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	0.84651270
97	HOXB7_26014856_ChIP-Seq_BT474_Human	0.83830945
98	IGF1R_20145208_ChIP-Seq_DFB_Human	0.83810622
99	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.83734202
100	MYC_19079543_ChIP-ChIP_MESCs_Mouse	0.83589386

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002102_abnormal_ear_morphology	3.42060884
2	MP0002638_abnormal_pupillary_reflex	3.36064206
3	MP0002234_abnormal_pharynx_morphology	2.96823233
4	MP0003880_abnormal_central_pattern	2.89190013
5	MP0003787_abnormal_imprinting	2.84181140
6	MP0008877_abnormal_DNA_methylation	2.83528145
7	MP0003646_muscle_fatigue	2.62291757
8	MP0006292_abnormal_olfactory_placode	2.44547285
9	MP0003011_delayed_dark_adaptation	2.33696426
10	MP0002163_abnormal_gland_morphology	2.27779363
11	MP0005551_abnormal_eye_electrophysiolog	2.27693632
12	MP0002736_abnormal_nociception_after	2.23267091
13	MP0009379_abnormal_foot_pigmentation	2.17181598
14	MP0001502_abnormal_circadian_rhythm	2.13078483
15	MP0004885_abnormal_endolymph	2.10339968
16	MP0005253_abnormal_eye_physiology	1.99123395
17	MP0004142_abnormal_muscle_tone	1.90367135
18	MP0004742_abnormal_vestibular_system	1.89787672
19	MP0001968_abnormal_touch/_nociception	1.86152107
20	MP0003136_yellow_coat_color	1.85431978
21	MP0008789_abnormal_olfactory_epithelium	1.83859992
22	MP0006054_spinal_hemorrhage	1.83274462
23	MP0006072_abnormal_retinal_apoptosis	1.79872859
24	MP0003123_paternal_imprinting	1.79614699
25	MP0001485_abnormal_pinna_reflex	1.77668465
26	MP0001661_extended_life_span	1.73394103
27	MP0001984_abnormal_olfaction	1.66844039
28	MP0004145_abnormal_muscle_electrophysio	1.57809871
29	MP0002272_abnormal_nervous_system	1.57172000
30	MP0009053_abnormal_anal_canal	1.52734145
31	MP0003283_abnormal_digestive_organ	1.50381179
32	MP0008872_abnormal_physiological_respon	1.50145993
33	MP0002876_abnormal_thyroid_physiology	1.47465498
34	MP0000778_abnormal_nervous_system	1.44429391
35	MP0004133_heterotaxia	1.44212234
36	MP0003121_genomic_imprinting	1.43078495
37	MP0002837_dystrophic_cardiac_calcinosis	1.42571212
38	MP0006276_abnormal_autonomic_nervous	1.41366118
39	MP0003122_maternal_imprinting	1.40720327
40	MP0002138_abnormal_hepatobiliary_system	1.40654218
41	MP0005394_taste/olfaction_phenotype	1.38775305
42	MP0005499_abnormal_olfactory_system	1.38775305
43	MP0000049_abnormal_middle_ear	1.36951127
44	MP0008875_abnormal_xenobiotic_pharmacok	1.35574010
45	MP0000647_abnormal_sebaceous_gland	1.34725609
46	MP0000427_abnormal_hair_cycle	1.33424990
47	MP0004147_increased_porphyrin_level	1.29812059
48	MP0001348_abnormal_lacrimal_gland	1.25375144
49	MP0005379_endocrine/exocrine_gland_phen	1.23282137
50	MP0002557_abnormal_social/conspecific_i	1.22485818
51	MP0009046_muscle_twitch	1.21368415
52	MP0001293_anophthalmia	1.20918319
53	MP0001529_abnormal_vocalization	1.20586493
54	MP0009745_abnormal_behavioral_response	1.19947271
55	MP0002090_abnormal_vision	1.18151253
56	MP0003195_calcinosis	1.11528514
57	MP0001486_abnormal_startle_reflex	1.08538956
58	MP0005195_abnormal_posterior_eye	1.08508707
59	MP0000026_abnormal_inner_ear	1.07331222
60	MP0003879_abnormal_hair_cell	1.04057620
61	MP0001905_abnormal_dopamine_level	1.03996100
62	MP0005646_abnormal_pituitary_gland	1.02578835
63	MP0002572_abnormal_emotion/affect_behav	1.02475807
64	MP0003119_abnormal_digestive_system	1.01034537
65	MP0002160_abnormal_reproductive_system	0.99717483
66	MP0006035_abnormal_mitochondrial_morpho	0.98946144
67	MP0002752_abnormal_somatic_nervous	0.97926172
68	MP0004043_abnormal_pH_regulation	0.97862012
69	MP0002095_abnormal_skin_pigmentation	0.97596582
70	MP0005423_abnormal_somatic_nervous	0.97374640
71	MP0000685_abnormal_immune_system	0.96386910
72	MP0000372_irregular_coat_pigmentation	0.96373441
73	MP0003186_abnormal_redox_activity	0.95896017
74	MP0000631_abnormal_neuroendocrine_gland	0.95687636
75	MP0005377_hearing/vestibular/ear_phenot	0.92786973
76	MP0003878_abnormal_ear_physiology	0.92786973
77	MP0001970_abnormal_pain_threshold	0.92292134
78	MP0002067_abnormal_sensory_capabilities	0.91799751
79	MP0002229_neurodegeneration	0.90595746
80	MP0003786_premature_aging	0.89267324
81	MP0001963_abnormal_hearing_physiology	0.88084128
82	MP0002938_white_spotting	0.87937214
83	MP0005391_vision/eye_phenotype	0.86761549
84	MP0002184_abnormal_innervation	0.86315910
85	MP0001286_abnormal_eye_development	0.85869631
86	MP0005389_reproductive_system_phenotype	0.84456955
87	MP0002734_abnormal_mechanical_nocicepti	0.84326559
88	MP0002064_seizures	0.83547176
89	MP0000613_abnormal_salivary_gland	0.83513778
90	MP0002063_abnormal_learning/memory/cond	0.82997725
91	MP0003567_abnormal_fetal_cardiomyocyte	0.80789735
92	MP0002233_abnormal_nose_morphology	0.80388663
93	MP0002733_abnormal_thermal_nociception	0.79344598
94	MP0001501_abnormal_sleep_pattern	0.79255889
95	MP0003635_abnormal_synaptic_transmissio	0.79074028
96	MP0006036_abnormal_mitochondrial_physio	0.79008283
97	MP0000383_abnormal_hair_follicle	0.78261235
98	MP0000579_abnormal_nail_morphology	0.77367865
99	MP0005084_abnormal_gallbladder_morpholo	0.75075403
100	MP0002751_abnormal_autonomic_nervous	0.74830895

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.38147519
2	Acute encephalopathy (HP:0006846)	4.07787082
3	Hepatocellular necrosis (HP:0001404)	3.97479496
4	Hyperglycinemia (HP:0002154)	3.91811759
5	Abnormal mitochondria in muscle tissue (HP:0008316)	3.87188429
6	Mitochondrial inheritance (HP:0001427)	3.82411566
7	Increased CSF lactate (HP:0002490)	3.56615164
8	Hepatic necrosis (HP:0002605)	3.53169960
9	Progressive macrocephaly (HP:0004481)	3.52974439
10	Medial flaring of the eyebrow (HP:0010747)	3.44847602
11	Reticulocytopenia (HP:0001896)	3.30304653
12	Congenital, generalized hypertrichosis (HP:0004540)	3.24358493
13	Pancreatic cysts (HP:0001737)	3.09026085
14	Gait imbalance (HP:0002141)	3.06279099
15	Optic disc pallor (HP:0000543)	3.00457329
16	Pancreatic fibrosis (HP:0100732)	2.99701188
17	Polyphagia (HP:0002591)	2.92186170
18	Septo-optic dysplasia (HP:0100842)	2.91642293
19	Methylmalonic aciduria (HP:0012120)	2.89340976
20	Congenital primary aphakia (HP:0007707)	2.82532717
21	Methylmalonic acidemia (HP:0002912)	2.78669238
22	Congenital stationary night blindness (HP:0007642)	2.78167940
23	Abnormality of the labia minora (HP:0012880)	2.72926146
24	Absent phalangeal crease (HP:0006109)	2.72788773
25	Molar tooth sign on MRI (HP:0002419)	2.70071393
26	Abnormality of midbrain morphology (HP:0002418)	2.70071393
27	Nephrogenic diabetes insipidus (HP:0009806)	2.69373835
28	Coronal craniosynostosis (HP:0004440)	2.66818855
29	Cerebral edema (HP:0002181)	2.63031448
30	Abnormality of cells of the erythroid lineage (HP:0012130)	2.55796987
31	True hermaphroditism (HP:0010459)	2.53819570
32	Increased serum lactate (HP:0002151)	2.50754405
33	Hyperglycinuria (HP:0003108)	2.42569337
34	Abnormality of the renal cortex (HP:0011035)	2.40113831
35	Increased hepatocellular lipid droplets (HP:0006565)	2.38473490
36	Adrenal hypoplasia (HP:0000835)	2.34826880
37	Abnormal rod and cone electroretinograms (HP:0008323)	2.34021099
38	Abnormal finger flexion creases (HP:0006143)	2.33377273
39	Optic nerve hypoplasia (HP:0000609)	2.32082364
40	Abnormality of serum amino acid levels (HP:0003112)	2.31246785
41	Lipid accumulation in hepatocytes (HP:0006561)	2.30649828
42	Lethargy (HP:0001254)	2.28026513
43	Abnormality of alanine metabolism (HP:0010916)	2.27314550
44	Hyperalaninemia (HP:0003348)	2.27314550
45	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.27314550
46	Abnormality of serine family amino acid metabolism (HP:0010894)	2.24215477
47	Abnormality of glycine metabolism (HP:0010895)	2.24215477
48	CNS demyelination (HP:0007305)	2.24089949
49	Sclerocornea (HP:0000647)	2.22098816
50	Nephronophthisis (HP:0000090)	2.21640966
51	Broad foot (HP:0001769)	2.21112659
52	Cerebral hypomyelination (HP:0006808)	2.17856604
53	Leukodystrophy (HP:0002415)	2.16624359
54	Lactic acidosis (HP:0003128)	2.16292703
55	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.15216443
56	Abnormal number of erythroid precursors (HP:0012131)	2.08609382
57	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.06840907
58	Colon cancer (HP:0003003)	2.04097668
59	Increased serum pyruvate (HP:0003542)	2.02678627
60	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.01762227
61	CNS hypomyelination (HP:0003429)	2.01739288
62	Brittle hair (HP:0002299)	2.01517916
63	Vaginal atresia (HP:0000148)	1.97961181
64	Status epilepticus (HP:0002133)	1.97712464
65	Respiratory failure (HP:0002878)	1.97703026
66	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.96373037
67	Genital tract atresia (HP:0001827)	1.95779725
68	Abnormality of DNA repair (HP:0003254)	1.95513994
69	Polyuria (HP:0000103)	1.95509320
70	Type II lissencephaly (HP:0007260)	1.93638094
71	Poor coordination (HP:0002370)	1.92963537
72	Blindness (HP:0000618)	1.90986406
73	Asplenia (HP:0001746)	1.89791003
74	Tubular atrophy (HP:0000092)	1.89442969
75	Pendular nystagmus (HP:0012043)	1.89319798
76	Occipital encephalocele (HP:0002085)	1.88989422
77	Atonic seizures (HP:0010819)	1.88507971
78	Hypoplasia of the ulna (HP:0003022)	1.88069240
79	Abnormal drinking behavior (HP:0030082)	1.87815775
80	Polydipsia (HP:0001959)	1.87815775
81	Retinal atrophy (HP:0001105)	1.87475238
82	Abnormality of the renal medulla (HP:0100957)	1.85656933
83	Impulsivity (HP:0100710)	1.85019894
84	3-Methylglutaconic aciduria (HP:0003535)	1.84517570
85	Neonatal respiratory distress (HP:0002643)	1.84318762
86	Exercise intolerance (HP:0003546)	1.84067553
87	Abolished electroretinogram (ERG) (HP:0000550)	1.82658149
88	Postaxial foot polydactyly (HP:0001830)	1.81871459
89	Entropion (HP:0000621)	1.80300165
90	Congenital malformation of the right heart (HP:0011723)	1.79836429
91	Double outlet right ventricle (HP:0001719)	1.79836429
92	Papilledema (HP:0001085)	1.78165336
93	Diplopia (HP:0000651)	1.77867361
94	Abnormality of binocular vision (HP:0011514)	1.77867361
95	X-linked dominant inheritance (HP:0001423)	1.77620549
96	Renal Fanconi syndrome (HP:0001994)	1.77442689
97	Aplasia/Hypoplasia of the ulna (HP:0006495)	1.76747354
98	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.76379246
99	Tachypnea (HP:0002789)	1.75932995
100	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.74109790

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	VRK2	3.43859663
2	TRIM28	2.88836440
3	CDC7	2.58209030
4	PDK2	2.53167151
5	GRK1	2.48238412
6	TAF1	2.36292602
7	TIE1	2.31841314
8	MAP4K2	2.29509230
9	EIF2AK1	2.16551016
10	MKNK2	2.14363181
11	DYRK2	2.06751069
12	TSSK6	1.99265237
13	TXK	1.95514122
14	WNK4	1.94903280
15	NME1	1.93135814
16	EPHA4	1.88458280
17	MAP3K12	1.87919423
18	BMPR1B	1.86832737
19	STK16	1.78883065
20	FRK	1.69479644
21	ADRBK2	1.68387615
22	NUAK1	1.66688938
23	OXSR1	1.47978827
24	STK39	1.46294816
25	EIF2AK3	1.42490576
26	TLK1	1.40507980
27	VRK1	1.39331388
28	PAK3	1.39120270
29	NEK1	1.37563556
30	PHKG2	1.36532435
31	PHKG1	1.36532435
32	EPHB2	1.35095220
33	WNK3	1.29755471
34	PINK1	1.28638849
35	CSNK1G2	1.27440414
36	CSNK1G1	1.25293207
37	BCKDK	1.23749337
38	CSNK1G3	1.21916186
39	ZAK	1.21501759
40	PLK2	1.13606692
41	AKT3	1.09914086
42	PRKCG	1.07706999
43	NTRK2	1.03747701
44	PLK3	1.01110733
45	CSNK1A1L	0.99647638
46	SRPK1	0.98630743
47	TYRO3	0.88096788
48	CDK8	0.87884532
49	MARK1	0.87466392
50	SIK3	0.87182193
51	MKNK1	0.86185331
52	CASK	0.85530280
53	INSRR	0.82558686
54	STK38L	0.82318107
55	MAP4K1	0.81518115
56	CDK19	0.78707979
57	MAPKAPK3	0.76813885
58	TGFBR1	0.75859769
59	MAP3K9	0.75559318
60	DAPK3	0.75272080
61	MAPKAPK5	0.74938767
62	PASK	0.68934767
63	MINK1	0.64119321
64	EIF2AK2	0.63427512
65	DAPK1	0.60132689
66	GRK5	0.59777439
67	PRKCI	0.58599118
68	CSNK1E	0.55312643
69	BCR	0.55021112
70	DYRK1A	0.54822062
71	PRKCE	0.54720131
72	ATR	0.53226524
73	MAPK13	0.53151695
74	CCNB1	0.52795143
75	RPS6KA5	0.52200999
76	PIK3CA	0.51269714
77	ADRBK1	0.49912470
78	PRKACA	0.49719557
79	PRKCQ	0.47146042
80	CSNK2A2	0.44466038
81	CDK14	0.44216900
82	CAMK1	0.42851110
83	SIK2	0.42753504
84	BRAF	0.42088417
85	PLK1	0.42065796
86	CSNK1A1	0.41560321
87	AURKA	0.41097494
88	PLK4	0.39998090
89	BUB1	0.39823465
90	MAP3K4	0.39219693
91	PRKCH	0.39168003
92	MST4	0.37543882
93	CAMK2A	0.37259945
94	IKBKB	0.36882801
95	CDK18	0.36447605
96	FES	0.35976688
97	AURKB	0.35575059
98	AKT2	0.35143596
99	PRKCD	0.35008723
100	CAMKK2	0.34011063

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.49029032
2	Proteasome_Homo sapiens_hsa03050	3.38920163
3	One carbon pool by folate_Homo sapiens_hsa00670	3.00268761
4	Ribosome_Homo sapiens_hsa03010	2.90187500
5	Parkinsons disease_Homo sapiens_hsa05012	2.83139844
6	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.82300325
7	Protein export_Homo sapiens_hsa03060	2.27437368
8	Propanoate metabolism_Homo sapiens_hsa00640	2.18672157
9	Huntingtons disease_Homo sapiens_hsa05016	2.14387362
10	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.10070214
11	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.99176237
12	Alzheimers disease_Homo sapiens_hsa05010	1.93031273
13	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.90499336
14	Basal transcription factors_Homo sapiens_hsa03022	1.88998233
15	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.88510990
16	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.87187552
17	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.78077898
18	Cardiac muscle contraction_Homo sapiens_hsa04260	1.76360299
19	Tryptophan metabolism_Homo sapiens_hsa00380	1.74085695
20	Linoleic acid metabolism_Homo sapiens_hsa00591	1.63703147
21	RNA polymerase_Homo sapiens_hsa03020	1.62676338
22	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.59015677
23	Steroid biosynthesis_Homo sapiens_hsa00100	1.57783991
24	Homologous recombination_Homo sapiens_hsa03440	1.57367149
25	beta-Alanine metabolism_Homo sapiens_hsa00410	1.50242263
26	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.49376328
27	RNA degradation_Homo sapiens_hsa03018	1.47966704
28	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.44806477
29	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.42388027
30	Glycerolipid metabolism_Homo sapiens_hsa00561	1.39138405
31	Phototransduction_Homo sapiens_hsa04744	1.36143095
32	Peroxisome_Homo sapiens_hsa04146	1.34857259
33	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.33957919
34	Mismatch repair_Homo sapiens_hsa03430	1.31623511
35	Butanoate metabolism_Homo sapiens_hsa00650	1.29596573
36	Pyruvate metabolism_Homo sapiens_hsa00620	1.28917177
37	Fanconi anemia pathway_Homo sapiens_hsa03460	1.28495821
38	Nucleotide excision repair_Homo sapiens_hsa03420	1.18420250
39	Histidine metabolism_Homo sapiens_hsa00340	1.14900408
40	Fatty acid degradation_Homo sapiens_hsa00071	1.14329802
41	Fatty acid elongation_Homo sapiens_hsa00062	1.13907442
42	Ether lipid metabolism_Homo sapiens_hsa00565	1.11719931
43	Selenocompound metabolism_Homo sapiens_hsa00450	1.09728493
44	Nitrogen metabolism_Homo sapiens_hsa00910	1.09351463
45	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.04384287
46	Arginine and proline metabolism_Homo sapiens_hsa00330	1.03450796
47	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.03449849
48	Non-homologous end-joining_Homo sapiens_hsa03450	0.99127278
49	Collecting duct acid secretion_Homo sapiens_hsa04966	0.93463294
50	Pyrimidine metabolism_Homo sapiens_hsa00240	0.90800896
51	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.90728889
52	Nicotine addiction_Homo sapiens_hsa05033	0.90263100
53	Lysine degradation_Homo sapiens_hsa00310	0.89224675
54	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.87403836
55	Sulfur metabolism_Homo sapiens_hsa00920	0.86332913
56	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.85691666
57	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.85581724
58	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.85480277
59	Fat digestion and absorption_Homo sapiens_hsa04975	0.85170118
60	Chemical carcinogenesis_Homo sapiens_hsa05204	0.83397225
61	Metabolic pathways_Homo sapiens_hsa01100	0.83083623
62	Basal cell carcinoma_Homo sapiens_hsa05217	0.79229754
63	Folate biosynthesis_Homo sapiens_hsa00790	0.73783461
64	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.70918856
65	Caffeine metabolism_Homo sapiens_hsa00232	0.67182022
66	RNA transport_Homo sapiens_hsa03013	0.66594685
67	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.66280433
68	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.66028374
69	Purine metabolism_Homo sapiens_hsa00230	0.64280768
70	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.64207055
71	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.64065655
72	Retinol metabolism_Homo sapiens_hsa00830	0.64020780
73	Glutathione metabolism_Homo sapiens_hsa00480	0.63985511
74	DNA replication_Homo sapiens_hsa03030	0.61318682
75	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.58378589
76	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.55964854
77	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.55918859
78	Sulfur relay system_Homo sapiens_hsa04122	0.55587806
79	Olfactory transduction_Homo sapiens_hsa04740	0.47525906
80	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.47095845
81	Base excision repair_Homo sapiens_hsa03410	0.46715015
82	Carbon metabolism_Homo sapiens_hsa01200	0.46420745
83	ABC transporters_Homo sapiens_hsa02010	0.45461966
84	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.44459239
85	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.43773484
86	Insulin secretion_Homo sapiens_hsa04911	0.43125394
87	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.42593104
88	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.42386771
89	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.41839371
90	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.40747552
91	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.39882908
92	Morphine addiction_Homo sapiens_hsa05032	0.39850757
93	Circadian rhythm_Homo sapiens_hsa04710	0.39702340
94	Spliceosome_Homo sapiens_hsa03040	0.39389582
95	Fatty acid metabolism_Homo sapiens_hsa01212	0.38963769
96	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.35945730
97	Glutamatergic synapse_Homo sapiens_hsa04724	0.32302892
98	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.30949584
99	Pancreatic secretion_Homo sapiens_hsa04972	0.28913568
100	Serotonergic synapse_Homo sapiens_hsa04726	0.27231407

GAPDHP23

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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