GAPDHP24

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)7.42980092
2DNA deamination (GO:0045006)6.23063533
3rRNA modification (GO:0000154)5.59001484
4fucose catabolic process (GO:0019317)5.27416866
5L-fucose metabolic process (GO:0042354)5.27416866
6L-fucose catabolic process (GO:0042355)5.27416866
7L-methionine biosynthetic process from methylthioadenosine (GO:0019509)5.03422071
8ribosomal small subunit assembly (GO:0000028)4.94289975
9rRNA methylation (GO:0031167)4.93154928
10purine deoxyribonucleotide catabolic process (GO:0009155)4.80528694
11regulation of chronic inflammatory response (GO:0002676)4.67780477
12proteasome assembly (GO:0043248)4.51919946
13cullin deneddylation (GO:0010388)4.36520551
14neuronal action potential propagation (GO:0019227)4.16698866
15pseudouridine synthesis (GO:0001522)4.14411012
16amino acid salvage (GO:0043102)4.10772315
17L-methionine salvage (GO:0071267)4.10772315
18L-methionine biosynthetic process (GO:0071265)4.10772315
19GTP biosynthetic process (GO:0006183)4.07490694
20water-soluble vitamin biosynthetic process (GO:0042364)4.04555376
21nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)4.02796156
22exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 4.01019280
23protein deneddylation (GO:0000338)3.98885478
24UTP metabolic process (GO:0046051)3.97866134
25negative regulation of JAK-STAT cascade (GO:0046426)3.95333466
26maturation of SSU-rRNA (GO:0030490)3.89605978
27negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.76999058
28amino acid activation (GO:0043038)3.70896042
29tRNA aminoacylation (GO:0043039)3.70896042
30DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.70811451
31base-excision repair, AP site formation (GO:0006285)3.70277109
32signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.66598840
33signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.66598840
34signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.66598840
35purine deoxyribonucleotide metabolic process (GO:0009151)3.66411466
36tRNA aminoacylation for protein translation (GO:0006418)3.62891419
37positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.61927886
38intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.61853434
39signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.61853434
40UTP biosynthetic process (GO:0006228)3.60420285
41CTP biosynthetic process (GO:0006241)3.55927476
42CTP metabolic process (GO:0046036)3.55927476
43pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.54263402
44mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.47702196
45regulation of cellular amino acid metabolic process (GO:0006521)3.47438593
46signal transduction involved in DNA damage checkpoint (GO:0072422)3.46934008
47signal transduction involved in DNA integrity checkpoint (GO:0072401)3.46934008
48signal transduction involved in cell cycle checkpoint (GO:0072395)3.45276903
49protein neddylation (GO:0045116)3.44584143
50energy coupled proton transport, down electrochemical gradient (GO:0015985)3.41593350
51ATP synthesis coupled proton transport (GO:0015986)3.41593350
52regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.34709277
53negative regulation of ligase activity (GO:0051352)3.28551184
54negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.28551184
55pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.24796804
56purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.24723536
57ribosome assembly (GO:0042255)3.19081862
58chromatin remodeling at centromere (GO:0031055)3.17841942
59anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.16616830
60platelet dense granule organization (GO:0060155)3.13088775
61establishment of protein localization to mitochondrial membrane (GO:0090151)3.12755166
62dopamine transport (GO:0015872)3.12223788
63protein complex biogenesis (GO:0070271)3.06710176
64pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.06272880
65AMP metabolic process (GO:0046033)3.06050164
66positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.05549610
67organelle disassembly (GO:1903008)3.03878489
68positive regulation of ligase activity (GO:0051351)3.01930384
69pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.01260827
70CENP-A containing nucleosome assembly (GO:0034080)3.01050055
71oligosaccharide biosynthetic process (GO:0009312)2.99946020
72mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.99596595
73keratinocyte development (GO:0003334)2.99531154
74mitochondrial respiratory chain complex I assembly (GO:0032981)2.93002802
75NADH dehydrogenase complex assembly (GO:0010257)2.93002802
76mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.93002802
77DNA strand renaturation (GO:0000733)2.91444376
78termination of RNA polymerase III transcription (GO:0006386)2.90186078
79transcription elongation from RNA polymerase III promoter (GO:0006385)2.90186078
80negative regulation of mast cell activation (GO:0033004)2.89548302
81deoxyribonucleotide catabolic process (GO:0009264)2.88259686
82antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.88012801
83positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)2.86025721
84methionine biosynthetic process (GO:0009086)2.83391808
85mitochondrial respiratory chain complex assembly (GO:0033108)2.82072991
86tRNA metabolic process (GO:0006399)2.82041885
87protein polyglutamylation (GO:0018095)2.80586910
88positive regulation of cell cycle arrest (GO:0071158)2.79496643
89purine nucleoside triphosphate biosynthetic process (GO:0009145)2.78929538
90DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.78601790
91ribosomal large subunit biogenesis (GO:0042273)2.77649758
92tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.77426599
93RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.77426599
94positive regulation of meiotic cell cycle (GO:0051446)2.76414101
95protein-cofactor linkage (GO:0018065)2.75428674
96fucosylation (GO:0036065)2.74402973
97positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.73881653
98tRNA processing (GO:0008033)2.73051724
99methionine metabolic process (GO:0006555)2.70920648
100negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.70672992

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.47607509
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.71164828
3CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.61528805
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.58376385
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.29328737
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.22359829
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.09187687
8ZNF274_21170338_ChIP-Seq_K562_Hela2.99786476
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.99256028
10VDR_22108803_ChIP-Seq_LS180_Human2.87227871
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.86658270
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.77786143
13MYC_18555785_ChIP-Seq_MESCs_Mouse2.55288167
14VDR_23849224_ChIP-Seq_CD4+_Human2.48109780
15IRF1_19129219_ChIP-ChIP_H3396_Human2.46635806
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.38872407
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.35599682
18FOXP3_21729870_ChIP-Seq_TREG_Human2.26765671
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.19885971
20PCGF2_27294783_Chip-Seq_ESCs_Mouse2.18884415
21YY1_21170310_ChIP-Seq_MESCs_Mouse2.14774872
22ELK1_19687146_ChIP-ChIP_HELA_Human2.06826014
23PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.03498689
24FLI1_27457419_Chip-Seq_LIVER_Mouse2.03433173
25MYC_18940864_ChIP-ChIP_HL60_Human1.85821814
26EWS_26573619_Chip-Seq_HEK293_Human1.85593876
27MYC_18358816_ChIP-ChIP_MESCs_Mouse1.83496029
28SRF_21415370_ChIP-Seq_HL-1_Mouse1.82341058
29THAP11_20581084_ChIP-Seq_MESCs_Mouse1.81899659
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.71490246
31PCGF2_27294783_Chip-Seq_NPCs_Mouse1.66123615
32FUS_26573619_Chip-Seq_HEK293_Human1.65186790
33MYC_19030024_ChIP-ChIP_MESCs_Mouse1.62528244
34PADI4_21655091_ChIP-ChIP_MCF-7_Human1.60156183
35FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.60112915
36IGF1R_20145208_ChIP-Seq_DFB_Human1.57135070
37RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.54208518
38TP53_22573176_ChIP-Seq_HFKS_Human1.53499195
39MYC_19079543_ChIP-ChIP_MESCs_Mouse1.51893929
40DCP1A_22483619_ChIP-Seq_HELA_Human1.48208685
41IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.47741660
42EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.46197918
43ZFP57_27257070_Chip-Seq_ESCs_Mouse1.41889483
44POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.41686950
45HOXB4_20404135_ChIP-ChIP_EML_Mouse1.38647795
46HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.35466406
47P300_19829295_ChIP-Seq_ESCs_Human1.34305076
48NOTCH1_21737748_ChIP-Seq_TLL_Human1.34111574
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.33565702
50GATA1_22025678_ChIP-Seq_K562_Human1.31178692
51TTF2_22483619_ChIP-Seq_HELA_Human1.30501178
52IRF8_22096565_ChIP-ChIP_GC-B_Human1.25838667
53POU3F2_20337985_ChIP-ChIP_501MEL_Human1.25274933
54IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.22800699
55NANOG_19829295_ChIP-Seq_ESCs_Human1.21802960
56SOX2_19829295_ChIP-Seq_ESCs_Human1.21802960
57MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.21577359
58SUZ12_27294783_Chip-Seq_NPCs_Mouse1.20832508
59BP1_19119308_ChIP-ChIP_Hs578T_Human1.20670799
60E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.19659030
61CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.19097082
62AR_20517297_ChIP-Seq_VCAP_Human1.17752376
63FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.16313544
64FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.16262785
65GABP_19822575_ChIP-Seq_HepG2_Human1.15301896
66XRN2_22483619_ChIP-Seq_HELA_Human1.14291918
67CIITA_25753668_ChIP-Seq_RAJI_Human1.12589496
68E2F1_18555785_ChIP-Seq_MESCs_Mouse1.06088671
69E2F4_17652178_ChIP-ChIP_JURKAT_Human1.05350245
70ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.05086201
71EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.05002869
72YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03069620
73AUTS2_25519132_ChIP-Seq_293T-REX_Human1.03068709
74NFE2_27457419_Chip-Seq_LIVER_Mouse1.02819656
75MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.01873875
76FOXH1_21741376_ChIP-Seq_EPCs_Human1.00389471
77EGR1_23403033_ChIP-Seq_LIVER_Mouse0.98973582
78GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.97253473
79IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.95896544
80CBP_20019798_ChIP-Seq_JUKART_Human0.95896544
81EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.95741987
82FOXA1_27270436_Chip-Seq_PROSTATE_Human0.93094107
83FOXA1_25329375_ChIP-Seq_VCAP_Human0.93094107
84CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.92211918
85ER_23166858_ChIP-Seq_MCF-7_Human0.91000586
86RBPJ_22232070_ChIP-Seq_NCS_Mouse0.90897472
87ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.88959966
88SALL4_22934838_ChIP-ChIP_CD34+_Human0.87891511
89ETV2_25802403_ChIP-Seq_MESCs_Mouse0.87242354
90CTBP2_25329375_ChIP-Seq_LNCAP_Human0.87161112
91ELK1_22589737_ChIP-Seq_MCF10A_Human0.86371641
92GATA3_26560356_Chip-Seq_TH2_Human0.85738260
93BCAT_22108803_ChIP-Seq_LS180_Human0.85505076
94CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.85478139
95PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.85476198
96MYC_19829295_ChIP-Seq_ESCs_Human0.83892900
97PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.82668761
98NCOR_22424771_ChIP-Seq_293T_Human0.80986626
99HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.77971589
100EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.77966834

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005645_abnormal_hypothalamus_physiol6.09409204
2MP0003283_abnormal_digestive_organ3.67413886
3MP0002138_abnormal_hepatobiliary_system3.38486310
4MP0005075_abnormal_melanosome_morpholog2.97185470
5MP0008058_abnormal_DNA_repair2.94732587
6MP0000685_abnormal_immune_system2.88188115
7MP0006292_abnormal_olfactory_placode2.51297833
8MP0008995_early_reproductive_senescence2.34257768
9MP0002102_abnormal_ear_morphology2.30147528
10MP0005671_abnormal_response_to2.19232604
11MP0001873_stomach_inflammation2.01084410
12MP0005084_abnormal_gallbladder_morpholo1.95363305
13MP0009697_abnormal_copulation1.95260724
14MP0001835_abnormal_antigen_presentation1.93461575
15MP0003786_premature_aging1.91201359
16MP0000372_irregular_coat_pigmentation1.88117767
17MP0004145_abnormal_muscle_electrophysio1.87925518
18MP0002653_abnormal_ependyma_morphology1.83643921
19MP0003252_abnormal_bile_duct1.83001612
20MP0002736_abnormal_nociception_after1.66033499
21MP0003186_abnormal_redox_activity1.65699847
22MP0001764_abnormal_homeostasis1.63177380
23MP0004885_abnormal_endolymph1.59853118
24MP0001501_abnormal_sleep_pattern1.58750557
25MP0008872_abnormal_physiological_respon1.56554760
26MP0001727_abnormal_embryo_implantation1.53524675
27MP0004147_increased_porphyrin_level1.52602023
28MP0002160_abnormal_reproductive_system1.52520828
29MP0002272_abnormal_nervous_system1.51154668
30MP0005085_abnormal_gallbladder_physiolo1.46071869
31MP0008875_abnormal_xenobiotic_pharmacok1.45420284
32MP0001440_abnormal_grooming_behavior1.42742536
33MP0003880_abnormal_central_pattern1.42183075
34MP0001968_abnormal_touch/_nociception1.41307207
35MP0006072_abnormal_retinal_apoptosis1.37533135
36MP0001790_abnormal_immune_system1.37474462
37MP0005387_immune_system_phenotype1.37474462
38MP0010094_abnormal_chromosome_stability1.35912666
39MP0003567_abnormal_fetal_cardiomyocyte1.31216909
40MP0003646_muscle_fatigue1.31029791
41MP0003195_calcinosis1.29996839
42MP0005389_reproductive_system_phenotype1.29744808
43MP0003718_maternal_effect1.29138064
44MP0005379_endocrine/exocrine_gland_phen1.27562321
45MP0005310_abnormal_salivary_gland1.26885821
46MP0008789_abnormal_olfactory_epithelium1.24934531
47MP0002166_altered_tumor_susceptibility1.24773058
48MP0002733_abnormal_thermal_nociception1.23518645
49MP0002735_abnormal_chemical_nociception1.23240171
50MP0006036_abnormal_mitochondrial_physio1.19555608
51MP0001529_abnormal_vocalization1.18935436
52MP0001663_abnormal_digestive_system1.17060389
53MP0004142_abnormal_muscle_tone1.15797228
54MP0002163_abnormal_gland_morphology1.15280902
55MP0008877_abnormal_DNA_methylation1.15055764
56MP0006054_spinal_hemorrhage1.15049428
57MP0001905_abnormal_dopamine_level1.09462697
58MP0002148_abnormal_hypersensitivity_rea1.09207236
59MP0005408_hypopigmentation1.07515842
60MP0001348_abnormal_lacrimal_gland1.07189924
61MP0009046_muscle_twitch1.05447201
62MP0002876_abnormal_thyroid_physiology1.02552454
63MP0002132_abnormal_respiratory_system1.02410929
64MP0001800_abnormal_humoral_immune1.01956934
65MP0002006_tumorigenesis0.99819218
66MP0003806_abnormal_nucleotide_metabolis0.99691696
67MP0009333_abnormal_splenocyte_physiolog0.94870193
68MP0005551_abnormal_eye_electrophysiolog0.92393799
69MP0003136_yellow_coat_color0.89878327
70MP0004133_heterotaxia0.89765538
71MP0002837_dystrophic_cardiac_calcinosis0.87552371
72MP0001119_abnormal_female_reproductive0.87212201
73MP0009745_abnormal_behavioral_response0.86121517
74MP0001986_abnormal_taste_sensitivity0.86067931
75MP0001970_abnormal_pain_threshold0.86012991
76MP0002210_abnormal_sex_determination0.85126294
77MP0009785_altered_susceptibility_to0.79209932
78MP0005253_abnormal_eye_physiology0.78377366
79MP0002332_abnormal_exercise_endurance0.76148015
80MP0002751_abnormal_autonomic_nervous0.75481574
81MP0003045_fibrosis0.75375665
82MP0004381_abnormal_hair_follicle0.74420878
83MP0000647_abnormal_sebaceous_gland0.73633069
84MP0001502_abnormal_circadian_rhythm0.72395380
85MP0003943_abnormal_hepatobiliary_system0.71749290
86MP0002938_white_spotting0.71185648
87MP0000631_abnormal_neuroendocrine_gland0.70441827
88MP0002405_respiratory_system_inflammati0.69702979
89MP0002184_abnormal_innervation0.68823410
90MP0001929_abnormal_gametogenesis0.66321414
91MP0005394_taste/olfaction_phenotype0.65919606
92MP0005499_abnormal_olfactory_system0.65919606
93MP0003866_abnormal_defecation0.65685009
94MP0004957_abnormal_blastocyst_morpholog0.65528858
95MP0002398_abnormal_bone_marrow0.65218399
96MP0005332_abnormal_amino_acid0.64913604
97MP0001919_abnormal_reproductive_system0.64460976
98MP0005365_abnormal_bile_salt0.64094764
99MP0003011_delayed_dark_adaptation0.64071752
100MP0005381_digestive/alimentary_phenotyp0.63818026

Predicted human phenotypes

RankGene SetZ-score
1Septo-optic dysplasia (HP:0100842)4.66991546
2Acute necrotizing encephalopathy (HP:0006965)4.57310247
3Unilateral renal agenesis (HP:0000122)4.56689776
4Acute encephalopathy (HP:0006846)4.13891463
5Increased hepatocellular lipid droplets (HP:0006565)4.09336723
6Increased CSF lactate (HP:0002490)4.09276814
7Mitochondrial inheritance (HP:0001427)3.88896916
8Abnormal mitochondria in muscle tissue (HP:0008316)3.85644994
9Lipid accumulation in hepatocytes (HP:0006561)3.72400878
10Progressive macrocephaly (HP:0004481)3.70642164
11Dyschromatopsia (HP:0007641)3.41877307
12Abnormality of midbrain morphology (HP:0002418)3.31694012
13Molar tooth sign on MRI (HP:0002419)3.31694012
14Increased serum lactate (HP:0002151)3.22234926
15Hepatocellular necrosis (HP:0001404)3.20901286
16Hypomagnesemia (HP:0002917)3.19890058
17Reticulocytopenia (HP:0001896)3.01730028
18Renal Fanconi syndrome (HP:0001994)2.93644280
19Cerebral edema (HP:0002181)2.87356145
20Cerebral hypomyelination (HP:0006808)2.86263672
21Abolished electroretinogram (ERG) (HP:0000550)2.85841638
22Optic disc pallor (HP:0000543)2.85725328
23Delayed CNS myelination (HP:0002188)2.82036701
24Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.79932419
25Hepatic necrosis (HP:0002605)2.79517676
26Respiratory difficulties (HP:0002880)2.72826904
27Hypoplasia of the pons (HP:0012110)2.69740506
28Abnormality of magnesium homeostasis (HP:0004921)2.66297069
29Pancreatic cysts (HP:0001737)2.63753137
30Chronic sinusitis (HP:0011109)2.59378061
31Abnormality of the pons (HP:0007361)2.51452476
32Poor head control (HP:0002421)2.48467323
33Hypoplasia of the capital femoral epiphysis (HP:0003090)2.46723986
34Exertional dyspnea (HP:0002875)2.46034498
35Dynein arm defect of respiratory motile cilia (HP:0012255)2.41868996
36Absent/shortened dynein arms (HP:0200106)2.41868996
37Maternal diabetes (HP:0009800)2.36792348
38True hermaphroditism (HP:0010459)2.36487680
39Colon cancer (HP:0003003)2.34382566
40Prostate neoplasm (HP:0100787)2.33290788
413-Methylglutaconic aciduria (HP:0003535)2.32967533
42Abnormality of the renal collecting system (HP:0004742)2.31626218
43Absent septum pellucidum (HP:0001331)2.30581687
44CNS demyelination (HP:0007305)2.25779011
45Pancytopenia (HP:0001876)2.25544033
46Lactic acidosis (HP:0003128)2.25332499
47Cellular immunodeficiency (HP:0005374)2.22917022
48Respiratory failure (HP:0002878)2.20007109
49Gonadotropin excess (HP:0000837)2.18731834
50Lethargy (HP:0001254)2.18464294
51Abnormality of the labia minora (HP:0012880)2.17321907
52Glycosuria (HP:0003076)2.13493937
53Abnormality of urine glucose concentration (HP:0011016)2.13493937
54Increased intramyocellular lipid droplets (HP:0012240)2.12957435
55Chronic otitis media (HP:0000389)2.12584579
56Exercise intolerance (HP:0003546)2.09390090
57Duplicated collecting system (HP:0000081)2.07670406
58Broad-based gait (HP:0002136)2.06342085
59Emotional lability (HP:0000712)2.05458501
60Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.04323622
61Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.00950171
62Abnormality of the prostate (HP:0008775)1.99680919
63Leukodystrophy (HP:0002415)1.98645060
64Neoplasm of the adrenal cortex (HP:0100641)1.94618045
65Polyuria (HP:0000103)1.93233612
66Type 2 muscle fiber atrophy (HP:0003554)1.93001130
67Chromosomal breakage induced by crosslinking agents (HP:0003221)1.92161345
68Oral leukoplakia (HP:0002745)1.91441448
69Optic nerve hypoplasia (HP:0000609)1.90677406
70Horizontal nystagmus (HP:0000666)1.88881536
71Amelogenesis imperfecta (HP:0000705)1.87202374
72Congenital, generalized hypertrichosis (HP:0004540)1.85804454
73Anosmia (HP:0000458)1.85337581
74Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.84102502
75Absent epiphyses (HP:0010577)1.84102502
76Abnormality of the septum pellucidum (HP:0007375)1.83857660
77IgG deficiency (HP:0004315)1.83271876
78Decreased electroretinogram (ERG) amplitude (HP:0000654)1.82429447
79Adrenal hypoplasia (HP:0000835)1.80961074
80Congenital stationary night blindness (HP:0007642)1.80131849
81Narrow forehead (HP:0000341)1.80083796
82CNS hypomyelination (HP:0003429)1.79946941
83Absent rod-and cone-mediated responses on ERG (HP:0007688)1.79395653
84Absent speech (HP:0001344)1.78239532
85Limb dystonia (HP:0002451)1.77736179
86Hyperphosphaturia (HP:0003109)1.77535754
87Abnormality of renal resorption (HP:0011038)1.77417117
88Abnormality of T cells (HP:0002843)1.75662227
89Hypoplastic pelvis (HP:0008839)1.75138157
90Inability to walk (HP:0002540)1.74213855
91Progressive microcephaly (HP:0000253)1.73661369
92Pancreatic fibrosis (HP:0100732)1.72385143
93Poor suck (HP:0002033)1.71902761
94Birth length less than 3rd percentile (HP:0003561)1.70751434
95Abnormal respiratory epithelium morphology (HP:0012253)1.70319434
96Abnormal respiratory motile cilium morphology (HP:0005938)1.70319434
97Thyroid-stimulating hormone excess (HP:0002925)1.69855038
98Alkalosis (HP:0001948)1.69382651
99Abnormality of the renal cortex (HP:0011035)1.68319556
100Aplasia/hypoplasia of the uterus (HP:0008684)1.67643939

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST46.37086185
2VRK23.91057129
3STK163.59159142
4NUAK13.33702296
5TAF13.24392338
6CCNB12.84952402
7EIF2AK12.35036315
8ZAK2.32245929
9TXK2.25632188
10TRIM282.16731774
11SRPK12.02234428
12WNK31.98088187
13NME11.88690213
14TSSK61.88432126
15VRK11.77260311
16TLK11.73232929
17INSRR1.55131748
18GRK11.46497946
19CDK81.45440937
20PHKG21.43387571
21PHKG11.43387571
22MAPKAPK31.40839816
23KIT1.35646766
24EIF2AK31.34854766
25PINK11.30593180
26PLK41.25354922
27DAPK11.22154239
28SIK31.15506331
29PBK1.14586256
30PLK31.12089102
31ADRBK21.10885074
32CDK191.06384482
33PASK1.05720559
34WEE11.04925993
35EIF2AK21.02102154
36PLK20.98262316
37BRSK20.97667349
38LATS10.97435837
39CSNK1G30.92370088
40JAK30.91297702
41CSNK1G10.89927147
42PIK3CA0.89525200
43MAP3K120.89015783
44FER0.85699929
45FRK0.83389863
46SMG10.78724920
47CSNK1G20.78532082
48GRK50.77361916
49CSNK1A1L0.76014106
50OXSR10.75771317
51BCR0.74285265
52DYRK20.74082428
53MAP2K60.73209033
54DAPK20.69074183
55SYK0.68587707
56MAP4K20.66635047
57TIE10.65551785
58TNIK0.65085727
59PDK20.64797568
60TEC0.64638367
61MINK10.63318318
62TGFBR10.62615291
63MAP4K10.62260871
64DAPK30.61081629
65MATK0.60723059
66MAP3K90.60352443
67PRKCI0.59444986
68BUB10.58453261
69ITK0.55369779
70PLK10.54070907
71BMPR1B0.52046246
72SCYL20.51354921
73CDK90.48040346
74MAPKAPK50.47313701
75EPHB20.46549436
76KDR0.45856472
77CDC70.45309076
78PTK2B0.44630819
79BRSK10.44050083
80RPS6KB20.43192647
81TYRO30.43062753
82PRKCQ0.39522358
83LYN0.38798966
84PRKCG0.38188655
85INSR0.37147906
86PRKCE0.36632197
87MYLK0.35783510
88LCK0.33863171
89NEK10.33327351
90RIPK40.32409736
91NLK0.32194618
92PRKACA0.31094519
93CSNK2A10.31009675
94OBSCN0.30892022
95STK390.30078913
96CAMK2D0.28401430
97PIK3CG0.28017066
98STK40.27582738
99EPHA40.27220334
100STK30.26858215

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.76795129
2Asthma_Homo sapiens_hsa053103.66221546
3Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.82359219
4Ribosome_Homo sapiens_hsa030102.62639545
5Oxidative phosphorylation_Homo sapiens_hsa001902.57101102
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.54928673
7Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.47710201
8Allograft rejection_Homo sapiens_hsa053302.34488849
9Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.30809085
10Protein export_Homo sapiens_hsa030602.29865780
11Autoimmune thyroid disease_Homo sapiens_hsa053202.29245856
12Parkinsons disease_Homo sapiens_hsa050122.26094555
13Type I diabetes mellitus_Homo sapiens_hsa049402.11846973
14Intestinal immune network for IgA production_Homo sapiens_hsa046722.07506340
15RNA polymerase_Homo sapiens_hsa030202.05072470
16Nucleotide excision repair_Homo sapiens_hsa034202.02355891
17Mismatch repair_Homo sapiens_hsa034301.99066019
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.89668284
19Homologous recombination_Homo sapiens_hsa034401.85483760
20Graft-versus-host disease_Homo sapiens_hsa053321.74629855
21Fanconi anemia pathway_Homo sapiens_hsa034601.74405542
22Basal transcription factors_Homo sapiens_hsa030221.67492031
23Huntingtons disease_Homo sapiens_hsa050161.63127039
24DNA replication_Homo sapiens_hsa030301.61864729
25Non-homologous end-joining_Homo sapiens_hsa034501.56380169
26Pyruvate metabolism_Homo sapiens_hsa006201.55469816
27RNA degradation_Homo sapiens_hsa030181.54279437
28Base excision repair_Homo sapiens_hsa034101.42278673
29Linoleic acid metabolism_Homo sapiens_hsa005911.37616617
30Caffeine metabolism_Homo sapiens_hsa002321.30838897
31Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.21251445
32Primary bile acid biosynthesis_Homo sapiens_hsa001201.20713851
33RNA transport_Homo sapiens_hsa030131.19260249
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.18197093
35Alzheimers disease_Homo sapiens_hsa050101.18042724
36Pyrimidine metabolism_Homo sapiens_hsa002401.13337605
37Cysteine and methionine metabolism_Homo sapiens_hsa002701.09973990
38Vitamin B6 metabolism_Homo sapiens_hsa007501.08406981
39Antigen processing and presentation_Homo sapiens_hsa046121.06513167
40Propanoate metabolism_Homo sapiens_hsa006401.05600004
41Purine metabolism_Homo sapiens_hsa002301.03018019
42Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.00340092
43Folate biosynthesis_Homo sapiens_hsa007900.99631686
44Hematopoietic cell lineage_Homo sapiens_hsa046400.90424713
45Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.89523497
46Spliceosome_Homo sapiens_hsa030400.83012698
47Primary immunodeficiency_Homo sapiens_hsa053400.81944663
48Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.80982752
49Olfactory transduction_Homo sapiens_hsa047400.79697615
50Ether lipid metabolism_Homo sapiens_hsa005650.79272650
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.78871770
52Viral myocarditis_Homo sapiens_hsa054160.77481999
53Sulfur relay system_Homo sapiens_hsa041220.76000005
54One carbon pool by folate_Homo sapiens_hsa006700.73405965
55Fatty acid elongation_Homo sapiens_hsa000620.73143632
56Rheumatoid arthritis_Homo sapiens_hsa053230.71159707
57Peroxisome_Homo sapiens_hsa041460.71071308
58Nitrogen metabolism_Homo sapiens_hsa009100.70416917
59Butanoate metabolism_Homo sapiens_hsa006500.66807798
60Regulation of autophagy_Homo sapiens_hsa041400.65445124
61Phototransduction_Homo sapiens_hsa047440.61527551
62Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61223653
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.60307177
64Systemic lupus erythematosus_Homo sapiens_hsa053220.59955138
65Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.59700468
66Cardiac muscle contraction_Homo sapiens_hsa042600.57518667
67Collecting duct acid secretion_Homo sapiens_hsa049660.56359323
68Metabolic pathways_Homo sapiens_hsa011000.55010753
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.54584183
70Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.52561299
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50804095
72Steroid hormone biosynthesis_Homo sapiens_hsa001400.49734181
73Morphine addiction_Homo sapiens_hsa050320.49051796
74Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.48497481
75Retinol metabolism_Homo sapiens_hsa008300.48075813
76Sulfur metabolism_Homo sapiens_hsa009200.47857488
77Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.46698312
78Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.46162605
79Maturity onset diabetes of the young_Homo sapiens_hsa049500.45409146
80Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.45256693
81Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.44884236
82Oocyte meiosis_Homo sapiens_hsa041140.44621406
83Nicotine addiction_Homo sapiens_hsa050330.42664615
84Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.42655069
85Biosynthesis of amino acids_Homo sapiens_hsa012300.40511958
86Taste transduction_Homo sapiens_hsa047420.39263927
87Arachidonic acid metabolism_Homo sapiens_hsa005900.39240821
88Tryptophan metabolism_Homo sapiens_hsa003800.36417056
89Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.35711797
90mRNA surveillance pathway_Homo sapiens_hsa030150.34409628
91Pentose phosphate pathway_Homo sapiens_hsa000300.33848168
92Fat digestion and absorption_Homo sapiens_hsa049750.32485578
93Epstein-Barr virus infection_Homo sapiens_hsa051690.31975077
94Carbon metabolism_Homo sapiens_hsa012000.30814383
95Herpes simplex infection_Homo sapiens_hsa051680.27181834
96Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.27133218
97Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.25616154
98Staphylococcus aureus infection_Homo sapiens_hsa051500.24582560
99Pentose and glucuronate interconversions_Homo sapiens_hsa000400.23540016
100Fatty acid degradation_Homo sapiens_hsa000710.21672574

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