GAPDHP25

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)6.55206503
2DNA deamination (GO:0045006)5.84007076
3establishment of protein localization to mitochondrial membrane (GO:0090151)5.09793571
4protein neddylation (GO:0045116)4.75072191
5mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.64429551
6energy coupled proton transport, down electrochemical gradient (GO:0015985)4.62642829
7ATP synthesis coupled proton transport (GO:0015986)4.62642829
8water-soluble vitamin biosynthetic process (GO:0042364)4.59822845
9rRNA modification (GO:0000154)4.34177436
10chaperone-mediated protein transport (GO:0072321)4.18174206
11regulation of cellular amino acid metabolic process (GO:0006521)4.16554886
12regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.13447286
13rRNA methylation (GO:0031167)4.10370165
14negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.01240480
15positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.80252755
16DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.79567035
17signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.68674228
18signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.68674228
19signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.68674228
20intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.67570431
21signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.67570431
22behavioral response to nicotine (GO:0035095)3.64968605
23exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.62809465
24regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.58782022
25nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.57423807
26GTP biosynthetic process (GO:0006183)3.56858998
27protein complex biogenesis (GO:0070271)3.54907135
28signal transduction involved in DNA integrity checkpoint (GO:0072401)3.54827727
29signal transduction involved in DNA damage checkpoint (GO:0072422)3.54827727
30negative regulation of ligase activity (GO:0051352)3.54001550
31negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.54001550
32maturation of 5.8S rRNA (GO:0000460)3.52914114
33signal transduction involved in cell cycle checkpoint (GO:0072395)3.51231218
34mitochondrial respiratory chain complex assembly (GO:0033108)3.36764039
35cullin deneddylation (GO:0010388)3.35932197
36anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.35166665
37fucose catabolic process (GO:0019317)3.32997044
38L-fucose metabolic process (GO:0042354)3.32997044
39L-fucose catabolic process (GO:0042355)3.32997044
40mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.31499978
41mitochondrial respiratory chain complex I assembly (GO:0032981)3.31499978
42NADH dehydrogenase complex assembly (GO:0010257)3.31499978
43positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.28107851
44cytidine deamination (GO:0009972)3.27607865
45cytidine metabolic process (GO:0046087)3.27607865
46cytidine catabolic process (GO:0006216)3.27607865
47respiratory chain complex IV assembly (GO:0008535)3.26872799
48platelet dense granule organization (GO:0060155)3.23919786
49electron transport chain (GO:0022900)3.12091782
50respiratory electron transport chain (GO:0022904)3.10463769
51cellular ketone body metabolic process (GO:0046950)3.09571664
52purine nucleoside triphosphate biosynthetic process (GO:0009145)3.08714900
53positive regulation of ligase activity (GO:0051351)3.08013671
54protein deneddylation (GO:0000338)3.06888340
55UTP biosynthetic process (GO:0006228)3.06402299
56regulation of cellular amine metabolic process (GO:0033238)3.04107008
57RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.02709137
58tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.02709137
59purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.02590375
60DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.01021691
61DNA strand renaturation (GO:0000733)3.00952092
62RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.00635373
63DNA double-strand break processing (GO:0000729)3.00139839
64intracellular protein transmembrane import (GO:0044743)2.94767476
65negative regulation of synaptic transmission, GABAergic (GO:0032229)2.93454441
66protein polyglutamylation (GO:0018095)2.90485820
67negative regulation of thymocyte apoptotic process (GO:0070244)2.89025165
68ketone body metabolic process (GO:1902224)2.86165708
69UTP metabolic process (GO:0046051)2.85858607
70ATP biosynthetic process (GO:0006754)2.85452915
71pseudouridine synthesis (GO:0001522)2.85287086
72cytochrome complex assembly (GO:0017004)2.85243274
73positive regulation of prostaglandin secretion (GO:0032308)2.84949425
74signal peptide processing (GO:0006465)2.83114838
75negative regulation of DNA-dependent DNA replication (GO:2000104)2.82342445
76antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.81467795
77mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.81266787
78positive regulation of cell cycle arrest (GO:0071158)2.79655447
79DNA catabolic process, exonucleolytic (GO:0000738)2.78989431
80protein-cofactor linkage (GO:0018065)2.78301946
81aldehyde catabolic process (GO:0046185)2.73972805
82hydrogen ion transmembrane transport (GO:1902600)2.72676682
83replication fork processing (GO:0031297)2.71570240
84ribosome assembly (GO:0042255)2.71425701
85regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.69801836
86regulation of thymocyte apoptotic process (GO:0070243)2.68478461
87kynurenine metabolic process (GO:0070189)2.67562777
88regulation of ubiquitin-protein transferase activity (GO:0051438)2.67384357
89pyrimidine ribonucleoside catabolic process (GO:0046133)2.65979829
90protein K6-linked ubiquitination (GO:0085020)2.64676710
91guanosine-containing compound biosynthetic process (GO:1901070)2.64201305
92nucleoside diphosphate phosphorylation (GO:0006165)2.60783386
93ribonucleoside triphosphate biosynthetic process (GO:0009201)2.60696320
94rRNA catabolic process (GO:0016075)2.60479250
95recombinational repair (GO:0000725)2.58936032
96antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.58337978
97response to pheromone (GO:0019236)2.57405669
98protein peptidyl-prolyl isomerization (GO:0000413)2.56528795
99ribosomal small subunit assembly (GO:0000028)2.56204148
100tRNA processing (GO:0008033)2.55781012

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.91813791
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.67091517
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.94137060
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.22306207
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.11548719
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.06320617
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.98156615
8ZNF274_21170338_ChIP-Seq_K562_Hela2.85346948
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.71328070
10VDR_22108803_ChIP-Seq_LS180_Human2.69342361
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.65936758
12VDR_23849224_ChIP-Seq_CD4+_Human2.62084094
13BP1_19119308_ChIP-ChIP_Hs578T_Human2.53844365
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.50156744
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.49083961
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.45809493
17ELK1_19687146_ChIP-ChIP_HELA_Human2.31466843
18FLI1_27457419_Chip-Seq_LIVER_Mouse2.23655725
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.20603752
20SRF_21415370_ChIP-Seq_HL-1_Mouse2.10513165
21PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.07225582
22EWS_26573619_Chip-Seq_HEK293_Human2.03420668
23E2F4_17652178_ChIP-ChIP_JURKAT_Human1.98445969
24FOXP3_21729870_ChIP-Seq_TREG_Human1.97227422
25IRF1_19129219_ChIP-ChIP_H3396_Human1.97172244
26PCGF2_27294783_Chip-Seq_ESCs_Mouse1.80626467
27RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.79337248
28HOXB4_20404135_ChIP-ChIP_EML_Mouse1.62523205
29HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.61734589
30MYC_18555785_ChIP-Seq_MESCs_Mouse1.60127401
31EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.59759042
32YY1_21170310_ChIP-Seq_MESCs_Mouse1.56376270
33DCP1A_22483619_ChIP-Seq_HELA_Human1.53773723
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.52967071
35PADI4_21655091_ChIP-ChIP_MCF-7_Human1.48308490
36FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.48295954
37IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.46885938
38PCGF2_27294783_Chip-Seq_NPCs_Mouse1.46155559
39MYC_18358816_ChIP-ChIP_MESCs_Mouse1.44974531
40TP53_22573176_ChIP-Seq_HFKS_Human1.42721248
41CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.42001511
42AR_20517297_ChIP-Seq_VCAP_Human1.41327038
43MYC_18940864_ChIP-ChIP_HL60_Human1.37876393
44NOTCH1_21737748_ChIP-Seq_TLL_Human1.36891832
45FOXA1_27270436_Chip-Seq_PROSTATE_Human1.34081232
46FOXA1_25329375_ChIP-Seq_VCAP_Human1.34081232
47ZFP57_27257070_Chip-Seq_ESCs_Mouse1.33797889
48PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.33653724
49MYC_19030024_ChIP-ChIP_MESCs_Mouse1.33544474
50GABP_19822575_ChIP-Seq_HepG2_Human1.32470423
51NANOG_19829295_ChIP-Seq_ESCs_Human1.30322997
52SOX2_19829295_ChIP-Seq_ESCs_Human1.30322997
53P300_19829295_ChIP-Seq_ESCs_Human1.28135820
54GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.27282067
55E2F1_18555785_ChIP-Seq_MESCs_Mouse1.24044680
56IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.17919438
57NCOR_22424771_ChIP-Seq_293T_Human1.17067809
58AUTS2_25519132_ChIP-Seq_293T-REX_Human1.14100711
59TTF2_22483619_ChIP-Seq_HELA_Human1.13320102
60CTBP1_25329375_ChIP-Seq_LNCAP_Human1.11934639
61THAP11_20581084_ChIP-Seq_MESCs_Mouse1.11101390
62TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10943361
63EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.08602217
64EGR1_23403033_ChIP-Seq_LIVER_Mouse1.08131074
65HOXB7_26014856_ChIP-Seq_BT474_Human1.07577958
66CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.07269456
67CTBP2_25329375_ChIP-Seq_LNCAP_Human1.05977423
68ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.04623284
69MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.04396899
70FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.02539019
71TCF4_22108803_ChIP-Seq_LS180_Human1.00457741
72IRF8_22096565_ChIP-ChIP_GC-B_Human1.00361196
73IGF1R_20145208_ChIP-Seq_DFB_Human1.00212821
74PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99186455
75GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.98551843
76SUZ12_27294783_Chip-Seq_NPCs_Mouse0.98420254
77FOXH1_21741376_ChIP-Seq_EPCs_Human0.98395063
78ELK1_22589737_ChIP-Seq_MCF10A_Human0.98026420
79GATA3_21878914_ChIP-Seq_MCF-7_Human0.97641796
80ER_23166858_ChIP-Seq_MCF-7_Human0.97156750
81BCAT_22108803_ChIP-Seq_LS180_Human0.95625776
82FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95024881
83UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.94605307
84NFE2_27457419_Chip-Seq_LIVER_Mouse0.94327335
85TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.94260568
86FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.93170084
87ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.92890194
88GATA3_26560356_Chip-Seq_TH2_Human0.92060204
89MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.91479249
90CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.89900218
91POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.88384452
92TAF2_19829295_ChIP-Seq_ESCs_Human0.88376139
93POU3F2_20337985_ChIP-ChIP_501MEL_Human0.88170207
94LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.87149138
95PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.86805253
96CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.86647577
97MYC_19829295_ChIP-Seq_ESCs_Human0.86384293
98NANOG_20526341_ChIP-Seq_ESCs_Human0.86097698
99KDM5A_27292631_Chip-Seq_BREAST_Human0.85842985
100CRX_20693478_ChIP-Seq_RETINA_Mouse0.85066420

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue3.84423133
2MP0002102_abnormal_ear_morphology3.83486032
3MP0003195_calcinosis2.80169538
4MP0008877_abnormal_DNA_methylation2.74173000
5MP0008872_abnormal_physiological_respon2.44415481
6MP0003806_abnormal_nucleotide_metabolis2.39005805
7MP0000372_irregular_coat_pigmentation2.35197622
8MP0002837_dystrophic_cardiac_calcinosis2.29657120
9MP0004147_increased_porphyrin_level2.24865911
10MP0005084_abnormal_gallbladder_morpholo2.17674168
11MP0008058_abnormal_DNA_repair2.16301442
12MP0005075_abnormal_melanosome_morpholog2.12646781
13MP0004145_abnormal_muscle_electrophysio2.12583810
14MP0006036_abnormal_mitochondrial_physio2.09268019
15MP0002138_abnormal_hepatobiliary_system2.05188722
16MP0005671_abnormal_response_to2.00976374
17MP0005167_abnormal_blood-brain_barrier2.00750594
18MP0008875_abnormal_xenobiotic_pharmacok1.97932503
19MP0001835_abnormal_antigen_presentation1.93708684
20MP0003186_abnormal_redox_activity1.85483236
21MP0003718_maternal_effect1.79490469
22MP0003011_delayed_dark_adaptation1.73433859
23MP0008775_abnormal_heart_ventricle1.71697060
24MP0008007_abnormal_cellular_replicative1.68937948
25MP0003693_abnormal_embryo_hatching1.62937207
26MP0002938_white_spotting1.59920612
27MP0005551_abnormal_eye_electrophysiolog1.58288701
28MP0003786_premature_aging1.57912736
29MP0010094_abnormal_chromosome_stability1.51975679
30MP0001873_stomach_inflammation1.50865633
31MP0000685_abnormal_immune_system1.50615286
32MP0006035_abnormal_mitochondrial_morpho1.48275328
33MP0004142_abnormal_muscle_tone1.46448861
34MP0005646_abnormal_pituitary_gland1.41843602
35MP0002148_abnormal_hypersensitivity_rea1.38105551
36MP0002736_abnormal_nociception_after1.37803774
37MP0001986_abnormal_taste_sensitivity1.33709976
38MP0002272_abnormal_nervous_system1.32371314
39MP0003950_abnormal_plasma_membrane1.31639088
40MP0004215_abnormal_myocardial_fiber1.31391549
41MP0001968_abnormal_touch/_nociception1.31127354
42MP0005645_abnormal_hypothalamus_physiol1.28746494
43MP0001764_abnormal_homeostasis1.27365274
44MP0003283_abnormal_digestive_organ1.26177555
45MP0009764_decreased_sensitivity_to1.25458560
46MP0006292_abnormal_olfactory_placode1.24800292
47MP0006072_abnormal_retinal_apoptosis1.23281119
48MP0004885_abnormal_endolymph1.20808539
49MP0005389_reproductive_system_phenotype1.19961994
50MP0001485_abnormal_pinna_reflex1.17973542
51MP0001800_abnormal_humoral_immune1.08069100
52MP0001501_abnormal_sleep_pattern1.06623009
53MP0005408_hypopigmentation1.05047224
54MP0002234_abnormal_pharynx_morphology1.04374752
55MP0003567_abnormal_fetal_cardiomyocyte1.03603510
56MP0003638_abnormal_response/metabolism_1.00386913
57MP0004957_abnormal_blastocyst_morpholog1.00232987
58MP0002876_abnormal_thyroid_physiology1.00179349
59MP0006276_abnormal_autonomic_nervous0.99766910
60MP0009333_abnormal_splenocyte_physiolog0.97853815
61MP0002653_abnormal_ependyma_morphology0.97489718
62MP0001919_abnormal_reproductive_system0.96860355
63MP0005332_abnormal_amino_acid0.96478458
64MP0009785_altered_susceptibility_to0.96300623
65MP0005083_abnormal_biliary_tract0.96120801
66MP0002160_abnormal_reproductive_system0.94085936
67MP0001881_abnormal_mammary_gland0.92374544
68MP0000427_abnormal_hair_cycle0.91352713
69MP0002006_tumorigenesis0.91143777
70MP0002095_abnormal_skin_pigmentation0.88161523
71MP0005253_abnormal_eye_physiology0.88022995
72MP0001663_abnormal_digestive_system0.85316381
73MP0005636_abnormal_mineral_homeostasis0.84696874
74MP0001790_abnormal_immune_system0.84530022
75MP0005387_immune_system_phenotype0.84530022
76MP0002733_abnormal_thermal_nociception0.82420158
77MP0004742_abnormal_vestibular_system0.82359545
78MP0001984_abnormal_olfaction0.80573968
79MP0008789_abnormal_olfactory_epithelium0.78999862
80MP0002090_abnormal_vision0.78874156
81MP0005410_abnormal_fertilization0.78736362
82MP0000383_abnormal_hair_follicle0.77626562
83MP0002166_altered_tumor_susceptibility0.76507233
84MP0004381_abnormal_hair_follicle0.75436677
85MP0009745_abnormal_behavioral_response0.75418426
86MP0001929_abnormal_gametogenesis0.75257074
87MP0010386_abnormal_urinary_bladder0.74626402
88MP0005464_abnormal_platelet_physiology0.73891622
89MP0001970_abnormal_pain_threshold0.73051217
90MP0000569_abnormal_digit_pigmentation0.72351313
91MP0000358_abnormal_cell_content/0.72268257
92MP0005000_abnormal_immune_tolerance0.71912866
93MP0000613_abnormal_salivary_gland0.71585322
94MP0000230_abnormal_systemic_arterial0.70524797
95MP0009046_muscle_twitch0.69821272
96MP0001905_abnormal_dopamine_level0.69800975
97MP0001879_abnormal_lymphatic_vessel0.69541522
98MP0001765_abnormal_ion_homeostasis0.68451123
99MP0004782_abnormal_surfactant_physiolog0.68352671
100MP0002210_abnormal_sex_determination0.68150287

Predicted human phenotypes

RankGene SetZ-score
1Hepatocellular necrosis (HP:0001404)4.36312631
2Acute necrotizing encephalopathy (HP:0006965)4.21467319
3Mitochondrial inheritance (HP:0001427)4.12598776
4Hepatic necrosis (HP:0002605)4.12008282
5Increased CSF lactate (HP:0002490)4.11681403
6Abnormal mitochondria in muscle tissue (HP:0008316)3.81315021
7Acute encephalopathy (HP:0006846)3.70737931
8Progressive macrocephaly (HP:0004481)3.48650700
9Increased serum lactate (HP:0002151)3.20548683
10Abnormality of alanine metabolism (HP:0010916)3.09729288
11Hyperalaninemia (HP:0003348)3.09729288
12Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.09729288
13Abnormality of B cell number (HP:0010975)3.02284637
14Optic disc pallor (HP:0000543)2.99814461
153-Methylglutaconic aciduria (HP:0003535)2.97571745
16Pancreatic cysts (HP:0001737)2.96595078
17Congenital stationary night blindness (HP:0007642)2.96441924
18Increased hepatocellular lipid droplets (HP:0006565)2.95336132
19Cerebral edema (HP:0002181)2.93219822
20Dyschromatopsia (HP:0007641)2.88271150
21Increased serum pyruvate (HP:0003542)2.83164918
22B lymphocytopenia (HP:0010976)2.82557752
23Lipid accumulation in hepatocytes (HP:0006561)2.77318676
24Molar tooth sign on MRI (HP:0002419)2.75200421
25Abnormality of midbrain morphology (HP:0002418)2.75200421
26IgG deficiency (HP:0004315)2.67886313
27Abnormality of glycolysis (HP:0004366)2.54601679
28Pancreatic fibrosis (HP:0100732)2.53346705
29Abolished electroretinogram (ERG) (HP:0000550)2.50042082
30Hypoproteinemia (HP:0003075)2.48088450
31CNS demyelination (HP:0007305)2.44779763
32True hermaphroditism (HP:0010459)2.44036335
33Methylmalonic aciduria (HP:0012120)2.43921617
34Constricted visual fields (HP:0001133)2.43554274
35Methylmalonic acidemia (HP:0002912)2.43066484
36Parakeratosis (HP:0001036)2.41166264
37Respiratory failure (HP:0002878)2.39898278
38Abnormality of the pons (HP:0007361)2.36819874
39Lactic acidosis (HP:0003128)2.35820779
40Abnormality of the labia minora (HP:0012880)2.32496190
41Type I transferrin isoform profile (HP:0003642)2.30945573
42Renal Fanconi syndrome (HP:0001994)2.29996819
43Degeneration of anterior horn cells (HP:0002398)2.29721421
44Abnormality of the anterior horn cell (HP:0006802)2.29721421
45Stomatitis (HP:0010280)2.24132530
46Decreased activity of mitochondrial respiratory chain (HP:0008972)2.23802122
47Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.23802122
48Colon cancer (HP:0003003)2.23442228
49Aplasia/hypoplasia of the uterus (HP:0008684)2.22763495
50Nephronophthisis (HP:0000090)2.21590148
51Elevated erythrocyte sedimentation rate (HP:0003565)2.21542883
52Pendular nystagmus (HP:0012043)2.19310211
53Dynein arm defect of respiratory motile cilia (HP:0012255)2.15925062
54Absent/shortened dynein arms (HP:0200106)2.15925062
55Abnormal protein glycosylation (HP:0012346)2.15004693
56Abnormal glycosylation (HP:0012345)2.15004693
57Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.15004693
58Abnormal protein N-linked glycosylation (HP:0012347)2.15004693
59Lethargy (HP:0001254)2.13152927
60Decreased electroretinogram (ERG) amplitude (HP:0000654)2.11804957
61Attenuation of retinal blood vessels (HP:0007843)2.11556750
62Abnormality of aspartate family amino acid metabolism (HP:0010899)2.11519182
63Abnormality of serum amino acid levels (HP:0003112)2.09500447
64Central scotoma (HP:0000603)2.06826624
65Exertional dyspnea (HP:0002875)2.04893759
66Abnormal respiratory motile cilium morphology (HP:0005938)2.04520431
67Abnormal respiratory epithelium morphology (HP:0012253)2.04520431
68Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.02484081
69Abnormality of the renal cortex (HP:0011035)2.01792969
70Hypomagnesemia (HP:0002917)2.00724070
71IgA deficiency (HP:0002720)1.96696844
72Exercise intolerance (HP:0003546)1.96319422
73Keratoconus (HP:0000563)1.95988878
74Increased corneal curvature (HP:0100692)1.95988878
75Congenital, generalized hypertrichosis (HP:0004540)1.95774381
76Severe combined immunodeficiency (HP:0004430)1.95219384
77Hypoplasia of the pons (HP:0012110)1.94673463
78Abnormality of the renal medulla (HP:0100957)1.94016365
79Increased intramyocellular lipid droplets (HP:0012240)1.93906463
80Tubular atrophy (HP:0000092)1.93887736
81Absent rod-and cone-mediated responses on ERG (HP:0007688)1.92703128
82Adactyly (HP:0009776)1.89929422
83Hypoplasia of the uterus (HP:0000013)1.89358854
84Chronic sinusitis (HP:0011109)1.88948187
85Decreased central vision (HP:0007663)1.85668326
86Supernumerary spleens (HP:0009799)1.84034435
87Abnormal drinking behavior (HP:0030082)1.80714096
88Polydipsia (HP:0001959)1.80714096
89Aplasia/Hypoplasia of the spleen (HP:0010451)1.80324387
90Leukodystrophy (HP:0002415)1.78662710
91Hyperglycinemia (HP:0002154)1.78251792
92Prostate neoplasm (HP:0100787)1.77235878
93Thyroiditis (HP:0100646)1.77082939
94Inability to walk (HP:0002540)1.75461272
95Abnormal rod and cone electroretinograms (HP:0008323)1.74841811
96Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.73579872
97Abnormal ciliary motility (HP:0012262)1.73153801
98Abnormality of magnesium homeostasis (HP:0004921)1.72637945
99Abnormality of methionine metabolism (HP:0010901)1.71444214
100Polyuria (HP:0000103)1.71069534

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.86658303
2NUAK13.61351583
3MST43.35755151
4TIE13.33398355
5EIF2AK32.95111557
6TAF12.67580552
7TSSK62.42906407
8FRK2.39174687
9MAP3K122.32543911
10GRK12.21764977
11VRK12.18350283
12BMPR1B2.15446990
13BUB12.14838625
14TRIM282.13366413
15STK391.89613715
16PLK31.72249654
17OXSR11.69154026
18TAOK31.67111228
19EIF2AK11.66663562
20ADRBK21.66498451
21ZAK1.59198978
22PDK21.57643292
23TLK11.53830228
24PLK21.50003411
25DAPK11.48737521
26WNK41.44988367
27NEK11.42271137
28TXK1.38521457
29TGFBR11.26952983
30STK161.25257123
31GRK51.17898120
32DYRK21.15868921
33MYLK1.15312486
34PLK41.14159144
35NME11.13895221
36CSNK1G11.13806431
37CCNB11.13718515
38EIF2AK21.13584383
39MAP3K91.09635968
40TEC1.08039953
41CSNK1G31.07951859
42WNK30.96656271
43CDK80.91693730
44MAP4K20.91469185
45CSNK1A1L0.90150427
46CSNK1G20.85977074
47IKBKB0.85647566
48ARAF0.85130977
49SRPK10.84413863
50BCKDK0.84014055
51MAPKAPK30.83975732
52SMG10.83655823
53ACVR1B0.81332265
54PBK0.80578289
55MAPKAPK50.79072929
56PHKG20.78012026
57PHKG10.78012026
58ILK0.76229438
59LIMK10.73718675
60SIK30.70406649
61PINK10.68894121
62PIK3CG0.67155544
63ADRBK10.64974612
64DAPK30.62321934
65PRKCI0.61866663
66MKNK10.60565765
67INSRR0.58198417
68PTK2B0.56683679
69DAPK20.54347684
70KIT0.54133954
71PLK10.53179977
72STK30.52981214
73IRAK10.51928936
74SYK0.50630788
75PRKCQ0.48211824
76MKNK20.46977939
77STK240.46772388
78SCYL20.44552080
79FLT30.43702853
80BCR0.42787263
81ATR0.41716831
82PASK0.41520155
83STK38L0.41335450
84MAPK130.39295895
85PRKCE0.37283804
86MINK10.36377433
87PRKCG0.36056448
88NLK0.35713083
89KDR0.34078430
90FER0.34023176
91GRK60.33374814
92STK40.31470672
93CDC70.30593827
94ERBB30.30036478
95MAP3K130.28785967
96OBSCN0.27475907
97CAMK2A0.25349464
98CSNK1A10.23662298
99ITK0.23323471
100BMPR20.22877480

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.25596755
2Oxidative phosphorylation_Homo sapiens_hsa001903.21880726
3Protein export_Homo sapiens_hsa030602.77770402
4Parkinsons disease_Homo sapiens_hsa050122.71523972
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.36124784
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.16019859
7Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.97389878
8Intestinal immune network for IgA production_Homo sapiens_hsa046721.96539047
9Primary immunodeficiency_Homo sapiens_hsa053401.89180374
10Asthma_Homo sapiens_hsa053101.88382074
11Homologous recombination_Homo sapiens_hsa034401.84452939
12Huntingtons disease_Homo sapiens_hsa050161.83434193
13RNA degradation_Homo sapiens_hsa030181.80145409
14RNA polymerase_Homo sapiens_hsa030201.75355374
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.74093434
16Propanoate metabolism_Homo sapiens_hsa006401.70242996
17Alzheimers disease_Homo sapiens_hsa050101.69191144
18Basal transcription factors_Homo sapiens_hsa030221.67040816
19Ribosome_Homo sapiens_hsa030101.64277987
20Non-homologous end-joining_Homo sapiens_hsa034501.63225271
21Nitrogen metabolism_Homo sapiens_hsa009101.62476347
22One carbon pool by folate_Homo sapiens_hsa006701.59262188
23Allograft rejection_Homo sapiens_hsa053301.50365318
24Vitamin B6 metabolism_Homo sapiens_hsa007501.46012121
25Tryptophan metabolism_Homo sapiens_hsa003801.39424992
26Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.35809394
27Mismatch repair_Homo sapiens_hsa034301.33939472
28Phototransduction_Homo sapiens_hsa047441.30631501
29Peroxisome_Homo sapiens_hsa041461.29600752
30Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.29591980
31Type I diabetes mellitus_Homo sapiens_hsa049401.29585193
32Butanoate metabolism_Homo sapiens_hsa006501.29053404
33Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.26342041
34Pyrimidine metabolism_Homo sapiens_hsa002401.26242184
35Sulfur metabolism_Homo sapiens_hsa009201.24460897
36RNA transport_Homo sapiens_hsa030131.23748060
37Linoleic acid metabolism_Homo sapiens_hsa005911.23398660
38Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.23235495
39alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.19624850
40Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.18837005
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.18197867
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.18057004
43Autoimmune thyroid disease_Homo sapiens_hsa053201.15260322
44Purine metabolism_Homo sapiens_hsa002301.10369012
45Fanconi anemia pathway_Homo sapiens_hsa034601.09601301
46Fatty acid elongation_Homo sapiens_hsa000621.09144302
47DNA replication_Homo sapiens_hsa030301.09060027
48Cysteine and methionine metabolism_Homo sapiens_hsa002701.08598075
49Cardiac muscle contraction_Homo sapiens_hsa042601.08549944
50Steroid biosynthesis_Homo sapiens_hsa001001.06058364
51Collecting duct acid secretion_Homo sapiens_hsa049661.05286160
52Graft-versus-host disease_Homo sapiens_hsa053321.04265788
53Nucleotide excision repair_Homo sapiens_hsa034201.04168819
542-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.99322038
55Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.99171380
56Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.99081074
57Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.95033831
58Antigen processing and presentation_Homo sapiens_hsa046120.87951678
59Pyruvate metabolism_Homo sapiens_hsa006200.86983247
60Rheumatoid arthritis_Homo sapiens_hsa053230.84013499
61Base excision repair_Homo sapiens_hsa034100.82578028
62Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.82526479
63Spliceosome_Homo sapiens_hsa030400.75679402
64Cyanoamino acid metabolism_Homo sapiens_hsa004600.75676633
65Selenocompound metabolism_Homo sapiens_hsa004500.75167129
66Caffeine metabolism_Homo sapiens_hsa002320.74829134
67Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.73803812
68Metabolic pathways_Homo sapiens_hsa011000.71694931
69Ether lipid metabolism_Homo sapiens_hsa005650.70882168
70SNARE interactions in vesicular transport_Homo sapiens_hsa041300.70103599
71Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.66821104
72Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.66296018
73Regulation of autophagy_Homo sapiens_hsa041400.65803232
74Carbon metabolism_Homo sapiens_hsa012000.64155732
75Arachidonic acid metabolism_Homo sapiens_hsa005900.62333069
76Fatty acid degradation_Homo sapiens_hsa000710.61152531
77Hematopoietic cell lineage_Homo sapiens_hsa046400.61017026
78Glutathione metabolism_Homo sapiens_hsa004800.58876285
79Pentose and glucuronate interconversions_Homo sapiens_hsa000400.58739343
80beta-Alanine metabolism_Homo sapiens_hsa004100.58273049
81Folate biosynthesis_Homo sapiens_hsa007900.57923571
82Primary bile acid biosynthesis_Homo sapiens_hsa001200.55751661
83Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.53858804
84Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.50026626
85Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.49324237
86Biosynthesis of amino acids_Homo sapiens_hsa012300.48576755
87Chemical carcinogenesis_Homo sapiens_hsa052040.45228173
88Fatty acid metabolism_Homo sapiens_hsa012120.43738716
89Steroid hormone biosynthesis_Homo sapiens_hsa001400.42742802
90Maturity onset diabetes of the young_Homo sapiens_hsa049500.41152047
91N-Glycan biosynthesis_Homo sapiens_hsa005100.40844637
92Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.40832696
93Serotonergic synapse_Homo sapiens_hsa047260.40596426
94Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38639653
95Nicotine addiction_Homo sapiens_hsa050330.36852982
96Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.35809378
97Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.35575849
98Fat digestion and absorption_Homo sapiens_hsa049750.34962432
99Retinol metabolism_Homo sapiens_hsa008300.33732925
100Glycerolipid metabolism_Homo sapiens_hsa005610.33682440

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