ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	negative regulation of nitric-oxide synthase activity (GO:0051001)	6.04401827
2	protein neddylation (GO:0045116)	5.59715618
3	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.34747390
4	ATP synthesis coupled proton transport (GO:0015986)	5.34747390
5	regulation of sarcomere organization (GO:0060297)	5.32138846
6	regulation of action potential (GO:0098900)	5.28928284
7	ribonucleoprotein complex disassembly (GO:0032988)	5.15997304
8	negative regulation of muscle hypertrophy (GO:0014741)	5.00664850
9	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.94810166
10	chaperone-mediated protein transport (GO:0072321)	4.90952892
11	organelle disassembly (GO:1903008)	4.90122142
12	negative regulation of cardiac muscle hypertrophy (GO:0010614)	4.48535768
13	behavioral response to nicotine (GO:0035095)	4.30092755
14	negative regulation of potassium ion transmembrane transporter activity (GO:1901017)	4.29444793
15	DNA deamination (GO:0045006)	4.29367076
16	platelet dense granule organization (GO:0060155)	4.16515922
17	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.14658251
18	ribosomal small subunit assembly (GO:0000028)	4.11808425
19	regulation of skeletal muscle contraction (GO:0014819)	4.07523920
20	plasma membrane repair (GO:0001778)	4.02245669
21	negative regulation of heart growth (GO:0061117)	3.98771289
22	negative regulation of cardiac muscle tissue growth (GO:0055022)	3.98771289
23	viral transcription (GO:0019083)	3.98085388
24	positive regulation of growth hormone secretion (GO:0060124)	3.97628204
25	translational termination (GO:0006415)	3.93450638
26	negative regulation of potassium ion transmembrane transport (GO:1901380)	3.80378117
27	growth hormone secretion (GO:0030252)	3.79674034
28	negative regulation of protein localization to cell surface (GO:2000009)	3.76626770
29	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.75261298
30	cotranslational protein targeting to membrane (GO:0006613)	3.70201976
31	protein targeting to ER (GO:0045047)	3.69096714
32	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.65376574
33	negative regulation of organelle assembly (GO:1902116)	3.63913377
34	negative regulation of monooxygenase activity (GO:0032769)	3.60869447
35	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.57916819
36	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.57637879
37	kinetochore organization (GO:0051383)	3.54482671
38	respiratory electron transport chain (GO:0022904)	3.50471023
39	electron transport chain (GO:0022900)	3.49633404
40	protein localization to endoplasmic reticulum (GO:0070972)	3.47161059
41	translational elongation (GO:0006414)	3.44469966
42	peptidyl-cysteine modification (GO:0018198)	3.41127611
43	protein complex biogenesis (GO:0070271)	3.38501943
44	substrate-independent telencephalic tangential migration (GO:0021826)	3.34905233
45	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	3.34905233
46	glycerophospholipid catabolic process (GO:0046475)	3.34777770
47	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO	3.32532920
48	regulation of chronic inflammatory response (GO:0002676)	3.31389698
49	negative regulation of cardiac muscle tissue development (GO:0055026)	3.28940650
50	cellular ketone body metabolic process (GO:0046950)	3.25089385
51	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc	3.22240132
52	regulation of p38MAPK cascade (GO:1900744)	3.22215004
53	GTP biosynthetic process (GO:0006183)	3.16878815
54	protein peptidyl-prolyl isomerization (GO:0000413)	3.08896428
55	kinetochore assembly (GO:0051382)	3.07727031
56	CDP-diacylglycerol biosynthetic process (GO:0016024)	3.07094255
57	regulation of growth hormone secretion (GO:0060123)	3.02623826
58	mitochondrial respiratory chain complex assembly (GO:0033108)	3.01726495
59	meiotic chromosome segregation (GO:0045132)	3.00813173
60	translation (GO:0006412)	3.00260775
61	hydrogen ion transmembrane transport (GO:1902600)	2.98796730
62	cellular protein complex disassembly (GO:0043624)	2.98738095
63	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.96812922
64	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.96812922
65	NADH dehydrogenase complex assembly (GO:0010257)	2.96812922
66	regulation of membrane repolarization (GO:0060306)	2.94094388
67	proton transport (GO:0015992)	2.93662412
68	genetic imprinting (GO:0071514)	2.90889410
69	negative regulation of potassium ion transport (GO:0043267)	2.90549799
70	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.88785774
71	hydrogen transport (GO:0006818)	2.87173767
72	ketone body metabolic process (GO:1902224)	2.86267266
73	somite development (GO:0061053)	2.85902925
74	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.85147359
75	signal peptide processing (GO:0006465)	2.83807247
76	ribosomal large subunit biogenesis (GO:0042273)	2.83614816
77	anterograde synaptic vesicle transport (GO:0048490)	2.82679760
78	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.82669352
79	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.81784718
80	parturition (GO:0007567)	2.80943122
81	anterograde axon cargo transport (GO:0008089)	2.76118682
82	ATP biosynthetic process (GO:0006754)	2.75126900
83	macromolecular complex disassembly (GO:0032984)	2.74087791
84	ribosomal small subunit biogenesis (GO:0042274)	2.72709308
85	viral life cycle (GO:0019058)	2.72666880
86	negative regulation of acute inflammatory response (GO:0002674)	2.71135664
87	forebrain morphogenesis (GO:0048853)	2.70849638
88	regulation of type B pancreatic cell apoptotic process (GO:2000674)	2.69836412
89	neural tube formation (GO:0001841)	2.68598053
90	negative regulation of oxidoreductase activity (GO:0051354)	2.68538078
91	UTP biosynthetic process (GO:0006228)	2.66947750
92	response to redox state (GO:0051775)	2.66578426
93	positive regulation of microtubule polymerization (GO:0031116)	2.66398391
94	CDP-diacylglycerol metabolic process (GO:0046341)	2.65025264
95	cellular component biogenesis (GO:0044085)	2.64249008
96	heart process (GO:0003015)	2.63568386
97	heart contraction (GO:0060047)	2.63568386
98	translational initiation (GO:0006413)	2.62946302
99	positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)	2.61248142
100	regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)	2.61214614

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	VDR_22108803_ChIP-Seq_LS180_Human	5.63770192
2	EZH2_22144423_ChIP-Seq_EOC_Human	4.81659624
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.01578009
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.56905135
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.32209115
6	ZNF274_21170338_ChIP-Seq_K562_Hela	3.14391408
7	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.82162411
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.75734957
9	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.65691611
10	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.53691432
11	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.42829860
12	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.38376173
13	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.25146471
14	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.13439884
15	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.12511151
16	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.00709868
17	ELK1_19687146_ChIP-ChIP_HELA_Human	1.94470689
18	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.89118924
19	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.81158509
20	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.68196394
21	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.65811355
22	EWS_26573619_Chip-Seq_HEK293_Human	1.60866249
23	REST_21632747_ChIP-Seq_MESCs_Mouse	1.55099223
24	IGF1R_20145208_ChIP-Seq_DFB_Human	1.52881290
25	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.52048074
26	VDR_23849224_ChIP-Seq_CD4+_Human	1.51884472
27	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.51328030
28	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.48096954
29	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.47891319
30	GBX2_23144817_ChIP-Seq_PC3_Human	1.47653336
31	P300_19829295_ChIP-Seq_ESCs_Human	1.46872007
32	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.46443634
33	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.45649458
34	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.44980445
35	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.41676898
36	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.36383893
37	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.34445976
38	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.32987485
39	FOXP3_21729870_ChIP-Seq_TREG_Human	1.29508969
40	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.27670399
41	BCAT_22108803_ChIP-Seq_LS180_Human	1.26439984
42	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.26078437
43	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.25817127
44	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.25533870
45	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.25257763
46	IRF1_19129219_ChIP-ChIP_H3396_Human	1.24742575
47	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.24221052
48	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.22703533
49	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.22556178
50	NCOR_22424771_ChIP-Seq_293T_Human	1.22530783
51	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.22316233
52	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.19330000
53	MYC_19829295_ChIP-Seq_ESCs_Human	1.19259913
54	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.18226052
55	MYC_18940864_ChIP-ChIP_HL60_Human	1.14371887
56	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.13630259
57	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.13430119
58	FUS_26573619_Chip-Seq_HEK293_Human	1.12462752
59	NANOG_20526341_ChIP-Seq_ESCs_Human	1.12208302
60	NANOG_19829295_ChIP-Seq_ESCs_Human	1.11467237
61	SOX2_19829295_ChIP-Seq_ESCs_Human	1.11467237
62	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.10089236
63	TAF2_19829295_ChIP-Seq_ESCs_Human	1.09739418
64	TTF2_22483619_ChIP-Seq_HELA_Human	1.09055899
65	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.08482869
66	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.08371371
67	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.07628780
68	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.05821755
69	TP53_22573176_ChIP-Seq_HFKS_Human	1.05172107
70	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.03138115
71	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.02617483
72	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.02449527
73	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.00737313
74	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.98972741
75	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.98298062
76	CBP_20019798_ChIP-Seq_JUKART_Human	0.98298062
77	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.96286150
78	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.95977047
79	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.95977047
80	RNF2_27304074_Chip-Seq_NSC_Mouse	0.93371065
81	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	0.92586705
82	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.90139350
83	ER_23166858_ChIP-Seq_MCF-7_Human	0.89913961
84	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.89612245
85	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.88319907
86	TCF4_22108803_ChIP-Seq_LS180_Human	0.88241218
87	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.88231889
88	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.87814843
89	GABP_19822575_ChIP-Seq_HepG2_Human	0.86982787
90	OCT4_20526341_ChIP-Seq_ESCs_Human	0.86178667
91	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.85768471
92	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.85768471
93	RNF2_18974828_ChIP-Seq_MESCs_Mouse	0.85639681
94	EZH2_18974828_ChIP-Seq_MESCs_Mouse	0.85639681
95	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.85004713
96	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.84588260
97	P53_21459846_ChIP-Seq_SAOS-2_Human	0.84011914
98	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.83674685
99	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.83566427
100	E2F4_17652178_ChIP-ChIP_JURKAT_Human	0.83404874

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003787_abnormal_imprinting	4.18280064
2	MP0003950_abnormal_plasma_membrane	4.01090859
3	MP0008877_abnormal_DNA_methylation	3.98705232
4	MP0002102_abnormal_ear_morphology	3.75797605
5	MP0003122_maternal_imprinting	3.30616718
6	MP0002837_dystrophic_cardiac_calcinosis	3.19187605
7	MP0003123_paternal_imprinting	3.14830990
8	MP0004145_abnormal_muscle_electrophysio	3.05479553
9	MP0004142_abnormal_muscle_tone	2.86246876
10	MP0004885_abnormal_endolymph	2.48579721
11	MP0002163_abnormal_gland_morphology	2.43204299
12	MP0002928_abnormal_bile_duct	2.37168715
13	MP0001348_abnormal_lacrimal_gland	2.35972642
14	MP0008872_abnormal_physiological_respon	2.35358725
15	MP0003121_genomic_imprinting	2.26097797
16	MP0008775_abnormal_heart_ventricle	2.11109201
17	MP0006292_abnormal_olfactory_placode	2.03227678
18	MP0003195_calcinosis	1.98988863
19	MP0003186_abnormal_redox_activity	1.98143512
20	MP0008789_abnormal_olfactory_epithelium	1.90883290
21	MP0003252_abnormal_bile_duct	1.80730748
22	MP0001968_abnormal_touch/_nociception	1.74829949
23	MP0004742_abnormal_vestibular_system	1.74617308
24	MP0002822_catalepsy	1.72862817
25	MP0000749_muscle_degeneration	1.71677083
26	MP0003136_yellow_coat_color	1.69254478
27	MP0001485_abnormal_pinna_reflex	1.63508110
28	MP0005551_abnormal_eye_electrophysiolog	1.59035979
29	MP0006072_abnormal_retinal_apoptosis	1.56807301
30	MP0001440_abnormal_grooming_behavior	1.54929427
31	MP0001486_abnormal_startle_reflex	1.49277704
32	MP0002272_abnormal_nervous_system	1.47575669
33	MP0003283_abnormal_digestive_organ	1.47322260
34	MP0008875_abnormal_xenobiotic_pharmacok	1.43418353
35	MP0005394_taste/olfaction_phenotype	1.41198757
36	MP0005499_abnormal_olfactory_system	1.41198757
37	MP0004381_abnormal_hair_follicle	1.39414329
38	MP0009379_abnormal_foot_pigmentation	1.38010391
39	MP0002138_abnormal_hepatobiliary_system	1.35003414
40	MP0003646_muscle_fatigue	1.34676391
41	MP0001984_abnormal_olfaction	1.33510345
42	MP0005379_endocrine/exocrine_gland_phen	1.30832292
43	MP0002095_abnormal_skin_pigmentation	1.27536881
44	MP0009745_abnormal_behavioral_response	1.24948411
45	MP0005174_abnormal_tail_pigmentation	1.23737268
46	MP0002557_abnormal_social/conspecific_i	1.15885874
47	MP0002063_abnormal_learning/memory/cond	1.15045168
48	MP0001970_abnormal_pain_threshold	1.13483266
49	MP0006036_abnormal_mitochondrial_physio	1.12839643
50	MP0000015_abnormal_ear_pigmentation	1.11655229
51	MP0000778_abnormal_nervous_system	1.11474144
52	MP0002733_abnormal_thermal_nociception	1.11034802
53	MP0002653_abnormal_ependyma_morphology	1.08549103
54	MP0003880_abnormal_central_pattern	1.08516052
55	MP0001986_abnormal_taste_sensitivity	1.07737693
56	MP0005377_hearing/vestibular/ear_phenot	1.07443403
57	MP0003878_abnormal_ear_physiology	1.07443403
58	MP0002184_abnormal_innervation	1.06693328
59	MP0006276_abnormal_autonomic_nervous	1.06678486
60	MP0000427_abnormal_hair_cycle	1.05927946
61	MP0003635_abnormal_synaptic_transmissio	1.05310790
62	MP0000230_abnormal_systemic_arterial	1.04551106
63	MP0002734_abnormal_mechanical_nocicepti	1.03762577
64	MP0002572_abnormal_emotion/affect_behav	1.01782869
65	MP0004084_abnormal_cardiac_muscle	0.99412806
66	MP0003119_abnormal_digestive_system	0.98178711
67	MP0004043_abnormal_pH_regulation	0.97944412
68	MP0001293_anophthalmia	0.97460010
69	MP0009046_muscle_twitch	0.96585681
70	MP0005389_reproductive_system_phenotype	0.95313864
71	MP0002938_white_spotting	0.91400425
72	MP0002067_abnormal_sensory_capabilities	0.89550292
73	MP0001324_abnormal_eye_pigmentation	0.89340100
74	MP0009250_abnormal_appendicular_skeleto	0.86473918
75	MP0000751_myopathy	0.85291082
76	MP0004270_analgesia	0.83149693
77	MP0005084_abnormal_gallbladder_morpholo	0.81777038
78	MP0006035_abnormal_mitochondrial_morpho	0.81473333
79	MP0005253_abnormal_eye_physiology	0.79961734
80	MP0002736_abnormal_nociception_after	0.79097425
81	MP0003938_abnormal_ear_development	0.77422572
82	MP0004215_abnormal_myocardial_fiber	0.77261595
83	MP0000955_abnormal_spinal_cord	0.77157498
84	MP0005167_abnormal_blood-brain_barrier	0.77135395
85	MP0004036_abnormal_muscle_relaxation	0.76406311
86	MP0001905_abnormal_dopamine_level	0.75201173
87	MP0002752_abnormal_somatic_nervous	0.75143088
88	MP0001873_stomach_inflammation	0.73873353
89	MP0002160_abnormal_reproductive_system	0.72989586
90	MP0001919_abnormal_reproductive_system	0.68969585
91	MP0000026_abnormal_inner_ear	0.67394477
92	MP0005195_abnormal_posterior_eye	0.66245100
93	MP0000049_abnormal_middle_ear	0.65961678
94	MP0003567_abnormal_fetal_cardiomyocyte	0.64897094
95	MP0008058_abnormal_DNA_repair	0.62426122
96	MP0001501_abnormal_sleep_pattern	0.61023766
97	MP0001879_abnormal_lymphatic_vessel	0.60584820
98	MP0002064_seizures	0.58548956
99	MP0003633_abnormal_nervous_system	0.56937137
100	MP0000631_abnormal_neuroendocrine_gland	0.56745753

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of the labia minora (HP:0012880)	5.22288727
2	Calf muscle hypertrophy (HP:0008981)	4.96342655
3	Acute necrotizing encephalopathy (HP:0006965)	4.52922956
4	Muscle hypertrophy of the lower extremities (HP:0008968)	4.36431820
5	Absent rod-and cone-mediated responses on ERG (HP:0007688)	4.14077753
6	Abnormal mitochondria in muscle tissue (HP:0008316)	4.09686071
7	Progressive macrocephaly (HP:0004481)	3.98381815
8	Acute encephalopathy (HP:0006846)	3.97074730
9	Hepatoblastoma (HP:0002884)	3.93441390
10	Reticulocytopenia (HP:0001896)	3.62060221
11	Mitochondrial inheritance (HP:0001427)	3.61961288
12	Hypoplasia of the thymus (HP:0000778)	3.48508764
13	3-Methylglutaconic aciduria (HP:0003535)	3.44123869
14	Increased CSF lactate (HP:0002490)	3.34674607
15	Hepatocellular necrosis (HP:0001404)	3.33727583
16	Pendular nystagmus (HP:0012043)	3.31573515
17	Neoplasm of the adrenal cortex (HP:0100641)	3.30351721
18	Keratoconus (HP:0000563)	3.26668148
19	Increased corneal curvature (HP:0100692)	3.26668148
20	Abnormality of DNA repair (HP:0003254)	3.19521397
21	Poor suck (HP:0002033)	3.03775308
22	Hepatic necrosis (HP:0002605)	3.03703207
23	Abnormal rod and cone electroretinograms (HP:0008323)	3.03160637
24	Pancreatic cysts (HP:0001737)	3.01157783
25	Exercise-induced muscle cramps (HP:0003710)	2.95573127
26	Abnormality of midbrain morphology (HP:0002418)	2.93906703
27	Molar tooth sign on MRI (HP:0002419)	2.93906703
28	Cerebral edema (HP:0002181)	2.86747334
29	Septo-optic dysplasia (HP:0100842)	2.86259949
30	Pancreatic fibrosis (HP:0100732)	2.79894822
31	Increased serum pyruvate (HP:0003542)	2.75097279
32	Abnormality of the renal cortex (HP:0011035)	2.72648669
33	Abnormality of the left ventricular outflow tract (HP:0011103)	2.68194378
34	Subaortic stenosis (HP:0001682)	2.68194378
35	Abnormality of cells of the erythroid lineage (HP:0012130)	2.67399100
36	Renal cortical cysts (HP:0000803)	2.63940560
37	Large for gestational age (HP:0001520)	2.60555064
38	Turricephaly (HP:0000262)	2.45749926
39	Abnormal pancreas size (HP:0012094)	2.44491985
40	Optic disc pallor (HP:0000543)	2.42255588
41	Growth hormone deficiency (HP:0000824)	2.37307910
42	Brushfield spots (HP:0001088)	2.35867413
43	Abnormality of magnesium homeostasis (HP:0004921)	2.35126927
44	True hermaphroditism (HP:0010459)	2.34820106
45	Muscle stiffness (HP:0003552)	2.34257581
46	Horseshoe kidney (HP:0000085)	2.32211823
47	Myotonia (HP:0002486)	2.31414825
48	Stenosis of the external auditory canal (HP:0000402)	2.30166133
49	Medial flaring of the eyebrow (HP:0010747)	2.29584799
50	Increased serum lactate (HP:0002151)	2.28493026
51	Hypomagnesemia (HP:0002917)	2.28099413
52	Neoplasm of the adrenal gland (HP:0100631)	2.28097041
53	Colon cancer (HP:0003003)	2.25667455
54	Exercise-induced myalgia (HP:0003738)	2.25249320
55	Decreased muscle mass (HP:0003199)	2.24940313
56	Abnormality of alanine metabolism (HP:0010916)	2.24735793
57	Hyperalaninemia (HP:0003348)	2.24735793
58	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.24735793
59	Supernumerary spleens (HP:0009799)	2.20898350
60	Abnormality of glycolysis (HP:0004366)	2.19932451
61	Increased hepatocellular lipid droplets (HP:0006565)	2.18712571
62	Congenital stationary night blindness (HP:0007642)	2.17924503
63	Renal Fanconi syndrome (HP:0001994)	2.08958460
64	Abolished electroretinogram (ERG) (HP:0000550)	2.07753793
65	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.04611629
66	Enlarged penis (HP:0000040)	2.03148118
67	Rib fusion (HP:0000902)	2.02544563
68	Respiratory failure (HP:0002878)	1.99296287
69	Palpebral edema (HP:0100540)	1.99253334
70	Papilledema (HP:0001085)	1.97247461
71	Metaphyseal dysplasia (HP:0100255)	1.96797682
72	Asplenia (HP:0001746)	1.91428639
73	Intestinal atresia (HP:0011100)	1.91202553
74	Sleep apnea (HP:0010535)	1.91176805
75	Lactic acidosis (HP:0003128)	1.89333875
76	Type 2 muscle fiber atrophy (HP:0003554)	1.88443516
77	Lipid accumulation in hepatocytes (HP:0006561)	1.88348783
78	Asymmetric septal hypertrophy (HP:0001670)	1.86412360
79	Nephronophthisis (HP:0000090)	1.84692028
80	Enlarged kidneys (HP:0000105)	1.82436558
81	Cystic liver disease (HP:0006706)	1.82328681
82	Methylmalonic aciduria (HP:0012120)	1.81915484
83	Sclerocornea (HP:0000647)	1.80133947
84	Decreased central vision (HP:0007663)	1.79863807
85	Leukodystrophy (HP:0002415)	1.79734917
86	Hyperglycinuria (HP:0003108)	1.79464968
87	Abnormal number of erythroid precursors (HP:0012131)	1.77876536
88	Exercise intolerance (HP:0003546)	1.77690337
89	Abnormality of the renal medulla (HP:0100957)	1.76706429
90	Oligodactyly (hands) (HP:0001180)	1.75739167
91	Furrowed tongue (HP:0000221)	1.75362205
92	Abnormal drinking behavior (HP:0030082)	1.75042711
93	Polydipsia (HP:0001959)	1.75042711
94	Methylmalonic acidemia (HP:0002912)	1.74220659
95	Myokymia (HP:0002411)	1.73769268
96	Optic nerve hypoplasia (HP:0000609)	1.73618213
97	Absent septum pellucidum (HP:0001331)	1.73588960
98	Entropion (HP:0000621)	1.73325014
99	Sudden death (HP:0001699)	1.73261209
100	Abnormality of the calf musculature (HP:0001430)	1.72786480

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	STK16	3.84159647
2	TIE1	3.53042665
3	TNIK	3.38757612
4	WNK4	3.02713555
5	VRK2	2.93582958
6	MAPKAPK5	2.92719145
7	ACVR1B	2.82802165
8	CDK8	2.78076370
9	BUB1	2.70518410
10	GRK1	2.68251116
11	FRK	2.49021806
12	ADRBK2	2.46979374
13	TLK1	1.97812294
14	CDK19	1.97496525
15	NUAK1	1.89194198
16	CCNB1	1.80759224
17	NEK1	1.78108488
18	PASK	1.73158639
19	MUSK	1.69729793
20	LIMK1	1.64743936
21	BCKDK	1.49220471
22	DYRK2	1.42727131
23	WNK3	1.37362681
24	PRKCG	1.36010410
25	BMPR1B	1.35117795
26	STK39	1.32635092
27	TAF1	1.30455590
28	PINK1	1.30223985
29	VRK1	1.29824505
30	PDK2	1.25831844
31	EIF2AK3	1.20577809
32	NTRK2	1.20194327
33	PAK6	1.19441335
34	PLK3	1.06510862
35	MAP4K2	1.04154197
36	GRK5	0.93314239
37	NME1	0.91821117
38	PLK4	0.89666859
39	MAP3K7	0.87922515
40	FGFR2	0.87381218
41	TGFBR1	0.86270911
42	CAMKK2	0.82125601
43	STK38L	0.82026098
44	NEK2	0.81822225
45	MELK	0.78051934
46	SCYL2	0.76337534
47	CSNK1G2	0.74998351
48	PIK3CA	0.74706184
49	AURKA	0.73863673
50	NTRK1	0.73373568
51	PBK	0.72853719
52	MAP3K12	0.72324681
53	ZAK	0.72054076
54	PIK3CG	0.71078296
55	DAPK3	0.70085977
56	WNK1	0.69029337
57	PLK2	0.68237298
58	EIF2AK1	0.66279767
59	PRKCH	0.64564127
60	PRKCI	0.64175040
61	INSRR	0.61015007
62	OXSR1	0.60866202
63	MARK1	0.59902779
64	PLK1	0.58752211
65	TNK2	0.55656015
66	CDK9	0.52880977
67	PAK3	0.52855748
68	PHKG2	0.51335835
69	PHKG1	0.51335835
70	ADRBK1	0.50725737
71	EPHB2	0.49612739
72	MARK2	0.48646716
73	AURKB	0.48480289
74	SGK223	0.48474940
75	SGK494	0.48474940
76	TESK1	0.47626755
77	SMG1	0.47608156
78	OBSCN	0.46757087
79	PRKCZ	0.46641223
80	MINK1	0.46347191
81	MOS	0.45269126
82	EIF2AK2	0.43710199
83	DAPK1	0.43685030
84	STK4	0.42692280
85	CSNK2A2	0.42613792
86	TSSK6	0.42589709
87	BRAF	0.42355316
88	PRKACB	0.40790531
89	TRIM28	0.40674481
90	PRKCQ	0.40439116
91	TAOK3	0.40307415
92	ABL2	0.40277968
93	MAP3K4	0.39950759
94	MAPK13	0.39338081
95	SIK2	0.38317584
96	EPHA4	0.37437007
97	CSNK1G3	0.36843542
98	CSNK1D	0.35499366
99	SGK1	0.35217883
100	STK3	0.33937654

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	4.26490591
2	Protein export_Homo sapiens_hsa03060	3.72800832
3	Ribosome_Homo sapiens_hsa03010	3.68155577
4	Parkinsons disease_Homo sapiens_hsa05012	3.58978298
5	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.86317270
6	Cardiac muscle contraction_Homo sapiens_hsa04260	2.78456044
7	Alzheimers disease_Homo sapiens_hsa05010	2.76763898
8	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.64024918
9	Vitamin B6 metabolism_Homo sapiens_hsa00750	2.63424497
10	Proteasome_Homo sapiens_hsa03050	2.63241241
11	Huntingtons disease_Homo sapiens_hsa05016	2.51311139
12	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.50103909
13	RNA polymerase_Homo sapiens_hsa03020	2.47913842
14	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.37735235
15	Propanoate metabolism_Homo sapiens_hsa00640	1.92162438
16	Mismatch repair_Homo sapiens_hsa03430	1.80574940
17	Nucleotide excision repair_Homo sapiens_hsa03420	1.73494142
18	Sulfur relay system_Homo sapiens_hsa04122	1.70204554
19	Homologous recombination_Homo sapiens_hsa03440	1.64594312
20	Linoleic acid metabolism_Homo sapiens_hsa00591	1.59797558
21	Tryptophan metabolism_Homo sapiens_hsa00380	1.59629013
22	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.52218787
23	Pyruvate metabolism_Homo sapiens_hsa00620	1.50326919
24	Basal transcription factors_Homo sapiens_hsa03022	1.48699982
25	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.37098680
26	RNA degradation_Homo sapiens_hsa03018	1.33868645
27	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.32186168
28	Peroxisome_Homo sapiens_hsa04146	1.29864198
29	Caffeine metabolism_Homo sapiens_hsa00232	1.28333291
30	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.27922182
31	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.23502492
32	Butanoate metabolism_Homo sapiens_hsa00650	1.17192331
33	Asthma_Homo sapiens_hsa05310	1.15232457
34	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.08177816
35	Fatty acid degradation_Homo sapiens_hsa00071	1.02272424
36	Nicotine addiction_Homo sapiens_hsa05033	1.01903952
37	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.01746591
38	Phototransduction_Homo sapiens_hsa04744	1.01458310
39	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.96599171
40	DNA replication_Homo sapiens_hsa03030	0.93629321
41	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.90561600
42	Nitrogen metabolism_Homo sapiens_hsa00910	0.86105365
43	Regulation of autophagy_Homo sapiens_hsa04140	0.85360398
44	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.84532691
45	One carbon pool by folate_Homo sapiens_hsa00670	0.84215879
46	Steroid biosynthesis_Homo sapiens_hsa00100	0.82047520
47	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.80952733
48	Pyrimidine metabolism_Homo sapiens_hsa00240	0.79662033
49	Fanconi anemia pathway_Homo sapiens_hsa03460	0.79266595
50	Ether lipid metabolism_Homo sapiens_hsa00565	0.76162182
51	beta-Alanine metabolism_Homo sapiens_hsa00410	0.74365067
52	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.73075478
53	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.72879276
54	Folate biosynthesis_Homo sapiens_hsa00790	0.72078376
55	Non-homologous end-joining_Homo sapiens_hsa03450	0.71683020
56	Fat digestion and absorption_Homo sapiens_hsa04975	0.70555609
57	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.69734401
58	Glycerolipid metabolism_Homo sapiens_hsa00561	0.67015033
59	Basal cell carcinoma_Homo sapiens_hsa05217	0.64971893
60	Insulin secretion_Homo sapiens_hsa04911	0.63190240
61	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.62971404
62	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.62368647
63	Metabolic pathways_Homo sapiens_hsa01100	0.61811160
64	Glutamatergic synapse_Homo sapiens_hsa04724	0.57481522
65	Selenocompound metabolism_Homo sapiens_hsa00450	0.56558999
66	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.56407425
67	RNA transport_Homo sapiens_hsa03013	0.52718094
68	Purine metabolism_Homo sapiens_hsa00230	0.50878705
69	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.50312005
70	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.50086369
71	Morphine addiction_Homo sapiens_hsa05032	0.49517108
72	Chemical carcinogenesis_Homo sapiens_hsa05204	0.48047670
73	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.46685219
74	Spliceosome_Homo sapiens_hsa03040	0.45665633
75	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.44272873
76	Serotonergic synapse_Homo sapiens_hsa04726	0.43126348
77	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.37775593
78	GABAergic synapse_Homo sapiens_hsa04727	0.32868579
79	p53 signaling pathway_Homo sapiens_hsa04115	0.32448601
80	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.32262073
81	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.30939292
82	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.29820207
83	Circadian entrainment_Homo sapiens_hsa04713	0.29405480
84	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.28616124
85	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.27782628
86	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.27708531
87	Histidine metabolism_Homo sapiens_hsa00340	0.26454634
88	Hippo signaling pathway_Homo sapiens_hsa04390	0.25778989
89	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.23473538
90	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.22725780
91	Taste transduction_Homo sapiens_hsa04742	0.22470560
92	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.22433650
93	Tyrosine metabolism_Homo sapiens_hsa00350	0.22035685
94	Colorectal cancer_Homo sapiens_hsa05210	0.21737276
95	Olfactory transduction_Homo sapiens_hsa04740	0.21709005
96	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.20919825
97	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.19450107
98	Allograft rejection_Homo sapiens_hsa05330	0.19350044
99	Retinol metabolism_Homo sapiens_hsa00830	0.19258199
100	Lysine degradation_Homo sapiens_hsa00310	0.19073676

GAPDHP27

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »