ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of sister chromatid cohesion (GO:0007063)	9.49754626
2	eosinophil migration (GO:0072677)	9.35750977
3	negative regulation of peptidyl-threonine phosphorylation (GO:0010801)	9.13775899
4	regulation of mononuclear cell migration (GO:0071675)	9.04894529
5	branch elongation of an epithelium (GO:0060602)	8.25656382
6	ribosomal small subunit assembly (GO:0000028)	8.04593594
7	negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)	8.01224076
8	L-fucose catabolic process (GO:0042355)	7.99664312
9	fucose catabolic process (GO:0019317)	7.99664312
10	L-fucose metabolic process (GO:0042354)	7.99664312
11	negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)	7.88525105
12	positive regulation of chromosome segregation (GO:0051984)	7.83798017
13	vesicle fusion (GO:0006906)	7.48054379
14	coenzyme A biosynthetic process (GO:0015937)	7.14447025
15	peptidyl-lysine dimethylation (GO:0018027)	6.95621782
16	autophagic vacuole fusion (GO:0000046)	6.79643780
17	macrophage chemotaxis (GO:0048246)	6.54997706
18	organ growth (GO:0035265)	6.48959294
19	localization within membrane (GO:0051668)	6.37641465
20	axis elongation (GO:0003401)	6.08793133
21	regulation of nitric-oxide synthase biosynthetic process (GO:0051769)	5.89458694
22	positive regulation of calcium ion import (GO:0090280)	5.83342080
23	regulation of T cell receptor signaling pathway (GO:0050856)	5.81862932
24	negative regulation of GTPase activity (GO:0034260)	5.67565349
25	negative regulation of GTP catabolic process (GO:0033125)	5.67565349
26	regulation of beta-amyloid formation (GO:1902003)	5.65633457
27	establishment of mitotic spindle orientation (GO:0000132)	5.60839027
28	monocyte chemotaxis (GO:0002548)	5.54823219
29	protein import into peroxisome matrix (GO:0016558)	5.51173925
30	double-strand break repair via nonhomologous end joining (GO:0006303)	5.43018981
31	non-recombinational repair (GO:0000726)	5.43018981
32	organelle membrane fusion (GO:0090174)	5.38876359
33	establishment of mitotic spindle localization (GO:0040001)	5.01006242
34	acrosome assembly (GO:0001675)	4.90084611
35	establishment of spindle orientation (GO:0051294)	4.88271246
36	detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)	4.78913778
37	oxidative demethylation (GO:0070989)	4.77364741
38	histone H3-K9 methylation (GO:0051567)	4.73276077
39	negative regulation of circadian rhythm (GO:0042754)	4.71583490
40	3-UTR-mediated mRNA stabilization (GO:0070935)	4.70657262
41	seminiferous tubule development (GO:0072520)	4.70091519
42	pantothenate metabolic process (GO:0015939)	4.67433806
43	organelle fusion (GO:0048284)	4.53808472
44	positive chemotaxis (GO:0050918)	4.52587845
45	regulation of amyloid precursor protein catabolic process (GO:1902991)	4.48474713
46	ribonucleoside bisphosphate biosynthetic process (GO:0034030)	4.46765679
47	nucleoside bisphosphate biosynthetic process (GO:0033866)	4.46765679
48	purine nucleoside bisphosphate biosynthetic process (GO:0034033)	4.46765679
49	fucose metabolic process (GO:0006004)	4.39473929
50	regulation of stem cell maintenance (GO:2000036)	4.37391643
51	positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)	4.35409254
52	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	4.31674391
53	coenzyme A metabolic process (GO:0015936)	4.17144614
54	fucosylation (GO:0036065)	4.12361029
55	regulation of antigen receptor-mediated signaling pathway (GO:0050854)	4.10843673
56	detection of chemical stimulus involved in sensory perception of taste (GO:0050912)	4.10806240
57	regulation of autophagic vacuole assembly (GO:2000785)	4.09587151
58	regulation of fibroblast growth factor receptor signaling pathway (GO:0040036)	4.04621592
59	protein targeting to vacuole (GO:0006623)	3.94410540
60	protein targeting to lysosome (GO:0006622)	3.94410540
61	establishment of protein localization to vacuole (GO:0072666)	3.94410540
62	single-organism membrane fusion (GO:0044801)	3.91338247
63	negative regulation of purine nucleotide catabolic process (GO:0033122)	3.90087360
64	proteasome assembly (GO:0043248)	3.87796731
65	histone H3-K9 modification (GO:0061647)	3.85246637
66	membrane budding (GO:0006900)	3.74966557
67	preassembly of GPI anchor in ER membrane (GO:0016254)	3.74595476
68	negative regulation of macroautophagy (GO:0016242)	3.73638020
69	negative regulation of nucleotide catabolic process (GO:0030812)	3.72571748
70	negative regulation of nucleoside metabolic process (GO:0045978)	3.64653453
71	regulation of mammary gland epithelial cell proliferation (GO:0033599)	3.60333482
72	regulation of cellular amide metabolic process (GO:0034248)	3.59529536
73	DNA integration (GO:0015074)	3.59033573
74	protein localization to peroxisome (GO:0072662)	3.58805248
75	protein targeting to peroxisome (GO:0006625)	3.58805248
76	establishment of protein localization to peroxisome (GO:0072663)	3.58805248
77	establishment of spindle localization (GO:0051293)	3.57713804
78	telomere maintenance via recombination (GO:0000722)	3.51989562
79	imidazole-containing compound metabolic process (GO:0052803)	3.43636988
80	ER to Golgi vesicle-mediated transport (GO:0006888)	3.43287547
81	DNA demethylation (GO:0080111)	3.41420102
82	regulation of calcium ion import (GO:0090279)	3.39996615
83	sodium-independent organic anion transport (GO:0043252)	3.38750896
84	regulation of peptidyl-threonine phosphorylation (GO:0010799)	3.38622022
85	iron-sulfur cluster assembly (GO:0016226)	3.35543173
86	metallo-sulfur cluster assembly (GO:0031163)	3.35543173
87	RNA methylation (GO:0001510)	3.33159357
88	regulation of vacuole organization (GO:0044088)	3.30978310
89	vesicle targeting (GO:0006903)	3.30881290
90	peroxisomal transport (GO:0043574)	3.29690186
91	regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:2	3.28894718
92	negative regulation of dendrite morphogenesis (GO:0050774)	3.25680491
93	protein prenylation (GO:0018342)	12.7860921
94	prenylation (GO:0097354)	12.7860921
95	negative regulation of Ras GTPase activity (GO:0034261)	12.1067742
96	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	12.0563109
97	positive regulation of mitotic sister chromatid separation (GO:1901970)	12.0563109
98	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	12.0563109
99	eosinophil chemotaxis (GO:0048245)	10.3473231
100	negative regulation of T cell receptor signaling pathway (GO:0050860)	10.2889279

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	9.33640035
2	VDR_22108803_ChIP-Seq_LS180_Human	6.36870871
3	NOTCH1_21737748_ChIP-Seq_TLL_Human	4.61849759
4	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	4.48793562
5	AR_21572438_ChIP-Seq_LNCaP_Human	3.41071805
6	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.04452088
7	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.63189165
8	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.50717501
9	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.50083670
10	YY1_21170310_ChIP-Seq_MESCs_Mouse	2.49258742
11	ZIC3_20872845_ChIP-ChIP_MESCs_Mouse	2.38037478
12	SRY_22984422_ChIP-ChIP_TESTIS_Rat	2.36255541
13	ZNF263_19887448_ChIP-Seq_K562_Human	2.15352116
14	GATA1_22025678_ChIP-Seq_K562_Human	10.8354507
15	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.86604652
16	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.81587293
17	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.78712660
18	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.77899104
19	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.77899104
20	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.77517385
21	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.73248729
22	RXR_22108803_ChIP-Seq_LS180_Human	1.63728696
23	BCAT_22108803_ChIP-Seq_LS180_Human	1.63388088
24	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.55647135
25	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.49483364
26	GBX2_23144817_ChIP-Seq_PC3_Human	1.49087749
27	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.47925119
28	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.44504073
29	TAF15_26573619_Chip-Seq_HEK293_Human	1.39735992
30	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.33062597
31	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.32766546
32	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.32766546
33	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.32766546
34	GATA3_26560356_Chip-Seq_TH1_Human	1.29164394
35	ZNF274_21170338_ChIP-Seq_K562_Hela	1.27087641
36	IRF1_19129219_ChIP-ChIP_H3396_Human	1.26529523
37	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.19438208
38	TP53_16413492_ChIP-PET_HCT116_Human	1.18922442
39	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.17271428
40	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.16959219
41	EZH2_22144423_ChIP-Seq_EOC_Human	1.14981566
42	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.12790757
43	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.11047637
44	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.03799361
45	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.99714559
46	GATA2_21666600_ChIP-Seq_HMVEC_Human	0.99305839
47	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.99133842
48	WDR5_24793694_ChIP-Seq_LNCAP_Human	0.98224262
49	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.92246583
50	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.91908427
51	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	0.88247799
52	TP53_22573176_ChIP-Seq_HFKS_Human	0.87579056
53	MYC_18555785_ChIP-Seq_MESCs_Mouse	0.87321790
54	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.85795454
55	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	0.83968586
56	RUNX_20019798_ChIP-Seq_JUKART_Human	0.83707813
57	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	0.82907772
58	FUS_26573619_Chip-Seq_HEK293_Human	0.81155913
59	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	0.79691854
60	TBX3_20139965_ChIP-Seq_ESCs_Mouse	0.79638594
61	TBX3_20139965_ChIP-Seq_MESCs_Mouse	0.78997844
62	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	0.77969084
63	P300_19829295_ChIP-Seq_ESCs_Human	0.77424567
64	SOX3_22085726_ChIP-Seq_MUSCLE_Mouse	0.75698908
65	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.75303305
66	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.75143734
67	CTCF_21964334_Chip-Seq_Bcells_Human	0.75020326
68	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.74759986
69	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.67881822
70	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.67881822
71	NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human	0.67327989
72	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	0.67293645
73	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.66872223
74	TCF4_22108803_ChIP-Seq_LS180_Human	0.65080635
75	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.64916656
76	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.64436041
77	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.64210189
78	ELF1_17652178_ChIP-ChIP_JURKAT_Human	0.62996514
79	HTT_18923047_ChIP-ChIP_STHdh_Human	0.62657591
80	STAT1_20625510_ChIP-Seq_HELA_Human	0.62440640
81	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.62304998
82	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.62130973
83	TRIM28_19339689_ChIP-ChIP_MESCs_Mouse	0.61876880
84	GATA3_21867929_ChIP-Seq_TH1_Mouse	0.61179426
85	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.60323446
86	ERG_20517297_ChIP-Seq_VCAP_Human	0.58354279
87	VDR_23849224_ChIP-Seq_CD4+_Human	0.58169066
88	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.57769469
89	NANOG_20526341_ChIP-Seq_ESCs_Human	0.57492383
90	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.57348274
91	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.56544072
92	CDX2_20551321_ChIP-Seq_CACO-2_Human	0.56293425
93	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.55974722
94	LUZP1_20508642_ChIP-Seq_ESCs_Mouse	0.54873812
95	NANOG_19829295_ChIP-Seq_ESCs_Human	0.54696642
96	SOX2_19829295_ChIP-Seq_ESCs_Human	0.54696642
97	OCT1_27270436_Chip-Seq_PROSTATE_Human	0.54123122
98	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.53398486
99	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.52938475
100	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.52588949

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003303_peritoneal_inflammation	9.75014873
2	MP0006082_CNS_inflammation	5.45461334
3	MP0000467_abnormal_esophagus_morphology	3.26469000
4	MP0001664_abnormal_digestion	3.25587441
5	MP0001663_abnormal_digestive_system	3.24985187
6	MP0001919_abnormal_reproductive_system	2.78789454
7	MP0002751_abnormal_autonomic_nervous	2.61943991
8	MP0005381_digestive/alimentary_phenotyp	2.48802779
9	MP0000383_abnormal_hair_follicle	2.41640690
10	MP0003115_abnormal_respiratory_system	2.32875375
11	MP0002876_abnormal_thyroid_physiology	2.04849395
12	MP0000566_synostosis	12.9008166
13	MP0005389_reproductive_system_phenotype	1.73261531
14	MP0005166_decreased_susceptibility_to	1.69657417
15	MP0003937_abnormal_limbs/digits/tail_de	1.65919999
16	MP0010678_abnormal_skin_adnexa	1.64133549
17	MP0001915_intracranial_hemorrhage	1.60341723
18	MP0000534_abnormal_ureter_morphology	1.48973646
19	MP0000428_abnormal_craniofacial_morphol	1.35574182
20	MP0005397_hematopoietic_system_phenotyp	1.35492071
21	MP0001545_abnormal_hematopoietic_system	1.35492071
22	MP0001293_anophthalmia	1.32131890
23	MP0003453_abnormal_keratinocyte_physiol	1.26578118
24	MP0001286_abnormal_eye_development	1.12948628
25	MP0005501_abnormal_skin_physiology	1.05272045
26	MP0000490_abnormal_crypts_of	1.00184290
27	MP0003763_abnormal_thymus_physiology	0.98440289
28	MP0005076_abnormal_cell_differentiation	0.98264111
29	MP0002019_abnormal_tumor_incidence	0.92439237
30	MP0001764_abnormal_homeostasis	0.91605999
31	MP0002109_abnormal_limb_morphology	0.88729407
32	MP0000858_altered_metastatic_potential	0.88254107
33	MP0001963_abnormal_hearing_physiology	0.83702861
34	MP0000470_abnormal_stomach_morphology	0.83054901
35	MP0000026_abnormal_inner_ear	0.81893789
36	MP0003329_amyloid_beta_deposits	0.79808546
37	MP0000358_abnormal_cell_content/	0.79655056
38	MP0003942_abnormal_urinary_system	0.76303829
39	MP0002115_abnormal_skeleton_extremities	0.75244813
40	MP0010155_abnormal_intestine_physiology	0.71508684
41	MP0008058_abnormal_DNA_repair	0.65521731
42	MP0002184_abnormal_innervation	0.62178225
43	MP0003195_calcinosis	0.62011847
44	MP0002210_abnormal_sex_determination	0.60477226
45	MP0005197_abnormal_uvea_morphology	0.59332754
46	MP0009763_increased_sensitivity_to	0.59145975
47	MP0000477_abnormal_intestine_morphology	0.59005188
48	MP0002837_dystrophic_cardiac_calcinosis	0.58938010
49	MP0002405_respiratory_system_inflammati	0.56876716
50	MP0005508_abnormal_skeleton_morphology	0.56220283
51	MP0000432_abnormal_head_morphology	0.55457056
52	MP0002102_abnormal_ear_morphology	0.54905813
53	MP0001986_abnormal_taste_sensitivity	0.54481551
54	MP0005253_abnormal_eye_physiology	0.53997111
55	MP0000604_amyloidosis	0.51514747
56	MP0009672_abnormal_birth_weight	0.51304175
57	MP0002277_abnormal_respiratory_mucosa	0.47792341
58	MP0001175_abnormal_lung_morphology	0.46552716
59	MP0000372_irregular_coat_pigmentation	0.45096543
60	MP0003935_abnormal_craniofacial_develop	0.43148688
61	MP0003638_abnormal_response/metabolism_	0.42991110
62	MP0005645_abnormal_hypothalamus_physiol	0.41109203
63	MP0002168_other_aberrant_phenotype	0.41096401
64	MP0004145_abnormal_muscle_electrophysio	0.39998930
65	MP0003936_abnormal_reproductive_system	0.39568347
66	MP0002113_abnormal_skeleton_development	0.38603387
67	MP0003646_muscle_fatigue	0.38437383
68	MP0003283_abnormal_digestive_organ	0.38030789
69	MP0005023_abnormal_wound_healing	0.38027196
70	MP0005391_vision/eye_phenotype	0.37933244
71	MP0002735_abnormal_chemical_nociception	0.36649412
72	MP0000377_abnormal_hair_follicle	0.36205194
73	MP0000681_abnormal_thyroid_gland	0.35192782
74	MP0003878_abnormal_ear_physiology	0.34906956
75	MP0005377_hearing/vestibular/ear_phenot	0.34906956
76	MP0002752_abnormal_somatic_nervous	0.34809826
77	MP0003136_yellow_coat_color	0.34608947
78	MP0002136_abnormal_kidney_physiology	0.33939006
79	MP0000627_abnormal_mammary_gland	0.33918517
80	MP0006292_abnormal_olfactory_placode	0.33462979
81	MP0002822_catalepsy	0.33396599
82	MP0005025_abnormal_response_to	0.33111778
83	MP0002736_abnormal_nociception_after	0.32199937
84	MP0006276_abnormal_autonomic_nervous	0.31906269
85	MP0000163_abnormal_cartilage_morphology	0.31405040
86	MP0002163_abnormal_gland_morphology	0.31374933
87	MP0005332_abnormal_amino_acid	0.30094301
88	MP0002452_abnormal_antigen_presenting	0.27572669
89	MP0001968_abnormal_touch/_nociception	0.26535751
90	MP0005084_abnormal_gallbladder_morpholo	0.25803196
91	MP0008872_abnormal_physiological_respon	0.25047630
92	MP0003448_altered_tumor_morphology	0.24116631
93	MP0002697_abnormal_eye_size	0.23067119
94	MP0008875_abnormal_xenobiotic_pharmacok	0.22462280
95	MP0001800_abnormal_humoral_immune	0.21807835
96	MP0010771_integument_phenotype	0.21690485
97	MP0005671_abnormal_response_to	0.21645506
98	MP0005085_abnormal_gallbladder_physiolo	0.21402312
99	MP0003011_delayed_dark_adaptation	0.21377862
100	MP0000049_abnormal_middle_ear	0.21292161

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Duplicated collecting system (HP:0000081)	9.57593489
2	Long foot (HP:0001833)	8.78230334
3	Abnormality of the renal collecting system (HP:0004742)	8.59936166
4	Large for gestational age (HP:0001520)	7.76814200
5	Acute lymphatic leukemia (HP:0006721)	7.05687065
6	Adactyly (HP:0009776)	6.51376337
7	Progressive muscle weakness (HP:0003323)	6.34397264
8	Hypoplastic pelvis (HP:0008839)	6.31399239
9	Abnormality of fatty-acid metabolism (HP:0004359)	5.97204036
10	Dry hair (HP:0011359)	5.77411807
11	Autoamputation (HP:0001218)	5.43484260
12	Pulmonary artery stenosis (HP:0004415)	5.18738758
13	Ureteral stenosis (HP:0000071)	5.18361174
14	Ureteral duplication (HP:0000073)	5.06275230
15	Steatorrhea (HP:0002570)	5.00692600
16	Brushfield spots (HP:0001088)	4.96300938
17	Menstrual irregularities (HP:0000858)	4.85176187
18	Ureteral obstruction (HP:0006000)	4.77477426
19	Hypoplastic nipples (HP:0002557)	4.58433844
20	Abnormal auditory evoked potentials (HP:0006958)	4.52330302
21	Reduced subcutaneous adipose tissue (HP:0003758)	4.30516114
22	Severe muscular hypotonia (HP:0006829)	4.12371156
23	Sudden death (HP:0001699)	4.11199838
24	Abnormal ventriculo-arterial connection (HP:0011563)	4.04094933
25	Transposition of the great arteries (HP:0001669)	4.04094933
26	Abnormal connection of the cardiac segments (HP:0011545)	4.04094933
27	Anhidrosis (HP:0000970)	4.02607165
28	Broad-based gait (HP:0002136)	3.85793712
29	Fat malabsorption (HP:0002630)	3.81700140
30	Increased number of teeth (HP:0011069)	3.75163021
31	Decreased lacrimation (HP:0000633)	3.73459456
32	Palmoplantar hyperkeratosis (HP:0000972)	3.60843508
33	Palmar hyperkeratosis (HP:0010765)	3.39805607
34	Abnormality of vision evoked potentials (HP:0000649)	3.37487170
35	Wide intermamillary distance (HP:0006610)	3.34535354
36	Polyneuropathy (HP:0001271)	3.25473653
37	Decreased muscle mass (HP:0003199)	3.21209407
38	Polymicrogyria (HP:0002126)	3.05377743
39	Clubbing of toes (HP:0100760)	2.96508094
40	Large hands (HP:0001176)	2.96043363
41	Generalized amyotrophy (HP:0003700)	2.92653090
42	Plantar hyperkeratosis (HP:0007556)	2.87310538
43	Broad nasal tip (HP:0000455)	2.85093717
44	Myoglobinuria (HP:0002913)	2.72504626
45	Rhabdomyolysis (HP:0003201)	2.67548960
46	Epiphyseal stippling (HP:0010655)	2.65983570
47	Chorioretinal coloboma (HP:0000567)	2.61717210
48	Flat face (HP:0012368)	2.59406566
49	Hypoplastic iliac wings (HP:0002866)	2.47314670
50	Widely spaced teeth (HP:0000687)	2.40394928
51	Overfolded helix (HP:0000396)	2.39470628
52	Basal ganglia calcification (HP:0002135)	2.38443791
53	Steppage gait (HP:0003376)	2.32015016
54	Posterior embryotoxon (HP:0000627)	2.25473635
55	Abnormality of the line of Schwalbe (HP:0008048)	2.20650169
56	Thickened calvaria (HP:0002684)	2.17215767
57	Female pseudohermaphroditism (HP:0010458)	2.15841340
58	Anxiety (HP:0000739)	2.15113021
59	Abnormally folded helix (HP:0008544)	2.12628715
60	Absent toe (HP:0010760)	2.03639631
61	Aplasia/Hypoplasia of the nipples (HP:0006709)	2.02853068
62	Purpura (HP:0000979)	2.01306055
63	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	11.7307441
64	Prenatal maternal abnormality (HP:0002686)	1.95752829
65	Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)	1.94815368
66	Lactic acidosis (HP:0003128)	1.91464322
67	Spastic tetraplegia (HP:0002510)	1.88775339
68	Abnormal epiphyseal ossification (HP:0010656)	1.87101845
69	External ear malformation (HP:0008572)	1.86494286
70	Congenital onset (HP:0003577)	1.86319729
71	Thickened nuchal skin fold (HP:0000474)	1.85347127
72	Foot dorsiflexor weakness (HP:0009027)	1.83872204
73	Gangrene (HP:0100758)	1.82621331
74	Arterial thrombosis (HP:0004420)	1.78149094
75	Arthrogryposis multiplex congenita (HP:0002804)	1.74077435
76	Generalized muscle weakness (HP:0003324)	1.72852350
77	Abnormality of the foot musculature (HP:0001436)	1.72096355
78	Primary adrenal insufficiency (HP:0008207)	1.71767096
79	Depressed nasal ridge (HP:0000457)	1.68623170
80	Short philtrum (HP:0000322)	1.66442661
81	Abnormality of the epiphyses of the hand (HP:0005924)	1.62646218
82	Scrotal hypoplasia (HP:0000046)	1.60839341
83	Hammertoe (HP:0001765)	1.60341652
84	Aplasia/Hypoplasia involving the pelvis (HP:0009103)	1.58156524
85	Abnormality involving the epiphyses of the upper limbs (HP:0003839)	1.57370401
86	Stereotypic behavior (HP:0000733)	1.56573602
87	Brachycephaly (HP:0000248)	1.51653804
88	Postnatal microcephaly (HP:0005484)	1.46112224
89	Nail dystrophy (HP:0008404)	1.43063486
90	Decreased motor nerve conduction velocity (HP:0003431)	1.42648897
91	Underdeveloped supraorbital ridges (HP:0009891)	1.41066194
92	Decreased number of peripheral myelinated nerve fibers (HP:0003380)	1.39007113
93	Retinopathy (HP:0000488)	1.36100428
94	Hypoplastic ilia (HP:0000946)	1.35079817
95	Metabolic acidosis (HP:0001942)	1.34588266
96	Pulmonary embolism (HP:0002204)	1.34382553
97	Opacification of the corneal stroma (HP:0007759)	1.33481986
98	Postnatal growth retardation (HP:0008897)	1.32928224
99	Respiratory insufficiency due to muscle weakness (HP:0002747)	1.31917347
100	Abnormality of primary teeth (HP:0006481)	1.30099702

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MKNK1	6.83569633
2	TAOK2	5.49419217
3	TAOK1	5.38779160
4	MAP3K11	4.07521609
5	MAP3K3	4.05120566
6	MAP2K3	3.86414049
7	JAK3	2.40651885
8	MKNK2	11.5695539
9	ABL2	1.87188743
10	DYRK1A	1.75715913
11	MAP3K5	1.34751450
12	SRPK1	1.13131532
13	MAP3K1	0.99435099
14	CHEK2	0.80726057
15	MAP3K8	0.64703198
16	PRKCQ	0.53084374
17	TIE1	0.38940057
18	GRK1	0.27996053
19	ADRBK2	0.21093197
20	CSNK1A1	0.19821969
21	ZAK	0.19337617
22	INSRR	0.16562888
23	IGF1R	0.16296921
24	WNK3	0.14951580
25	ABL1	0.14802432
26	TXK	0.12793992
27	OBSCN	0.12790071
28	PASK	0.10502344
29	FRK	0.10121910
30	PRKCD	0.10087400
31	MAP4K2	0.09081387
32	VRK1	0.08648133
33	MUSK	0.08572181
34	VRK2	0.08493997
35	CSNK2A2	0.07772080
36	NUAK1	0.07414210
37	TEC	0.06536251
38	PIK3CG	0.06261957
39	TLK1	0.06089191
40	BMPR1B	0.05570154
41	CSNK1E	0.05516566
42	WNK4	0.04926396
43	TGFBR2	0.04874107
44	CSNK2A1	0.04707808
45	PHKG2	0.03862467
46	PHKG1	0.03862467
47	GRK7	0.03585186
48	KIT	0.03157644
49	STK39	0.02187663
50	PLK3	0.02007447
51	TSSK6	0.01616007
52	PLK4	0.01086284
53	PRKCA	0.01055548
54	AURKA	0.00384633
55	OXSR1	0.00224648
56	GRK5	0.00016424
57	MAP3K4	-0.1022156
58	DAPK3	-0.1003299
59	MAP4K1	-0.0995428
60	MAP2K7	-0.0962313
61	PRKG1	-0.0940694
62	DYRK2	-0.0920235
63	LYN	-0.0911857
64	WEE1	-0.0890611
65	CAMK2A	-0.0887888
66	MYLK	-0.0879102
67	AKT3	-0.0866721
68	EIF2AK3	-0.0844787
69	MAPKAPK5	-0.0836888
70	SYK	-0.0823576
71	PRKCE	-0.0758815
72	PLK2	-0.0701685
73	MAP3K12	-0.0698294
74	PAK3	-0.0696082
75	GRK6	-0.0690541
76	BTK	-0.0673950
77	NTRK3	-0.0635772
78	PIK3CA	-0.0611443
79	KDR	-0.0608085
80	ADRBK1	-0.0595657
81	TNIK	-0.0533185
82	MATK	-0.0526582
83	MAP2K6	-0.0523005
84	PRKCG	-0.0522574
85	BCKDK	-0.0512691
86	ITK	-0.0418021
87	TAOK3	-0.0379435
88	SIK2	-0.0372684
89	SRC	-0.0344358
90	TGFBR1	-0.0301969
91	CCNB1	-0.0272980
92	PINK1	-0.0271913
93	MAPK15	-0.0255303
94	FES	-0.0244697
95	ERBB4	-0.0213786
96	BCR	-0.0197203
97	PDK2	-0.0164906
98	TRIM28	-0.0107773
99	PRKACA	-0.0098455
100	PRKCB	-0.0015646

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	7.98249790
2	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	6.71671453
3	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.42883591
4	RNA polymerase_Homo sapiens_hsa03020	3.33304938
5	Taste transduction_Homo sapiens_hsa04742	2.99294998
6	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.95626009
7	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	2.80406392
8	Fatty acid elongation_Homo sapiens_hsa00062	2.78829178
9	Proteasome_Homo sapiens_hsa03050	2.67738094
10	Butanoate metabolism_Homo sapiens_hsa00650	2.56399510
11	Lysine degradation_Homo sapiens_hsa00310	2.27609760
12	One carbon pool by folate_Homo sapiens_hsa00670	2.14572189
13	Tryptophan metabolism_Homo sapiens_hsa00380	2.02394079
14	beta-Alanine metabolism_Homo sapiens_hsa00410	1.86792297
15	Propanoate metabolism_Homo sapiens_hsa00640	1.82625584
16	Glycerolipid metabolism_Homo sapiens_hsa00561	1.76775015
17	Amoebiasis_Homo sapiens_hsa05146	1.33908252
18	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.31092977
19	Fatty acid degradation_Homo sapiens_hsa00071	1.18331632
20	Viral myocarditis_Homo sapiens_hsa05416	1.05766913
21	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.05183483
22	Fatty acid metabolism_Homo sapiens_hsa01212	1.04575162
23	Peroxisome_Homo sapiens_hsa04146	1.01242826
24	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.93993054
25	Caffeine metabolism_Homo sapiens_hsa00232	0.86280440
26	Asthma_Homo sapiens_hsa05310	0.82575436
27	Pyrimidine metabolism_Homo sapiens_hsa00240	0.76557771
28	Linoleic acid metabolism_Homo sapiens_hsa00591	0.74396657
29	Complement and coagulation cascades_Homo sapiens_hsa04610	0.74289446
30	Nucleotide excision repair_Homo sapiens_hsa03420	0.74147367
31	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.71489611
32	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.68819949
33	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.68527664
34	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.68256043
35	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.68220405
36	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.67873806
37	Allograft rejection_Homo sapiens_hsa05330	0.64797160
38	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.63029411
39	Nicotine addiction_Homo sapiens_hsa05033	0.62174717
40	Retinol metabolism_Homo sapiens_hsa00830	0.60271652
41	Olfactory transduction_Homo sapiens_hsa04740	0.55864669
42	RNA transport_Homo sapiens_hsa03013	0.55852491
43	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.53053059
44	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.51890742
45	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.50972230
46	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.50267410
47	Type I diabetes mellitus_Homo sapiens_hsa04940	0.49787838
48	Phototransduction_Homo sapiens_hsa04744	0.49648062
49	Graft-versus-host disease_Homo sapiens_hsa05332	0.49165421
50	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.49041636
51	Purine metabolism_Homo sapiens_hsa00230	0.46223188
52	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.46072153
53	Fat digestion and absorption_Homo sapiens_hsa04975	0.44088194
54	Chemical carcinogenesis_Homo sapiens_hsa05204	0.43783457
55	Primary immunodeficiency_Homo sapiens_hsa05340	0.41538263
56	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.40240985
57	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.39969041
58	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.38212122
59	Cholinergic synapse_Homo sapiens_hsa04725	0.37832670
60	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.36583432
61	AMPK signaling pathway_Homo sapiens_hsa04152	0.36499222
62	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.36144387
63	TNF signaling pathway_Homo sapiens_hsa04668	0.34291442
64	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.34116503
65	Nitrogen metabolism_Homo sapiens_hsa00910	0.33929226
66	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.33586224
67	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.33115307
68	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.30926937
69	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.30865547
70	Tyrosine metabolism_Homo sapiens_hsa00350	0.28878332
71	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.28496806
72	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.27718458
73	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.26593824
74	Metabolic pathways_Homo sapiens_hsa01100	0.25714794
75	MicroRNAs in cancer_Homo sapiens_hsa05206	0.25488775
76	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.25159762
77	Rheumatoid arthritis_Homo sapiens_hsa05323	0.24903207
78	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.23268306
79	Huntingtons disease_Homo sapiens_hsa05016	0.22039378
80	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.20135648
81	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.20092979
82	Malaria_Homo sapiens_hsa05144	0.20010488
83	Salmonella infection_Homo sapiens_hsa05132	0.19203939
84	Selenocompound metabolism_Homo sapiens_hsa00450	0.18992419
85	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.18027853
86	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.17528530
87	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.17433769
88	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.17232675
89	Protein digestion and absorption_Homo sapiens_hsa04974	0.17145562
90	Toxoplasmosis_Homo sapiens_hsa05145	0.15207338
91	GnRH signaling pathway_Homo sapiens_hsa04912	0.15132627
92	African trypanosomiasis_Homo sapiens_hsa05143	0.14070142
93	Phagosome_Homo sapiens_hsa04145	0.12785621
94	Ribosome_Homo sapiens_hsa03010	0.11554135
95	Steroid biosynthesis_Homo sapiens_hsa00100	0.08651459
96	Cardiac muscle contraction_Homo sapiens_hsa04260	0.08011797
97	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.07738275
98	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.07305701
99	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.06899149
100	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.06878817

GAPDHP28

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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