

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 6.15987590 |
| 2 | proteasome assembly (GO:0043248) | 6.06830025 |
| 3 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 5.72666996 |
| 4 | DNA deamination (GO:0045006) | 5.36225250 |
| 5 | ATP synthesis coupled proton transport (GO:0015986) | 5.35725340 |
| 6 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 5.35725340 |
| 7 | GTP biosynthetic process (GO:0006183) | 5.09872216 |
| 8 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 4.92344580 |
| 9 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 4.92344580 |
| 10 | NADH dehydrogenase complex assembly (GO:0010257) | 4.92344580 |
| 11 | rRNA modification (GO:0000154) | 4.71539134 |
| 12 | protein complex biogenesis (GO:0070271) | 4.67535537 |
| 13 | UTP biosynthetic process (GO:0006228) | 4.59523141 |
| 14 | chaperone-mediated protein transport (GO:0072321) | 4.52605331 |
| 15 | mitochondrial respiratory chain complex assembly (GO:0033108) | 4.40443093 |
| 16 | guanosine-containing compound biosynthetic process (GO:1901070) | 4.17919603 |
| 17 | UTP metabolic process (GO:0046051) | 4.17259588 |
| 18 | rRNA methylation (GO:0031167) | 4.11283942 |
| 19 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.99926978 |
| 20 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 3.99449966 |
| 21 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.86142802 |
| 22 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.85286574 |
| 23 | termination of RNA polymerase III transcription (GO:0006386) | 3.84409238 |
| 24 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.84409238 |
| 25 | establishment of integrated proviral latency (GO:0075713) | 3.84018471 |
| 26 | pseudouridine synthesis (GO:0001522) | 3.82980104 |
| 27 | establishment of viral latency (GO:0019043) | 3.81590226 |
| 28 | CTP metabolic process (GO:0046036) | 3.77478327 |
| 29 | CTP biosynthetic process (GO:0006241) | 3.77478327 |
| 30 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.76663230 |
| 31 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.75950938 |
| 32 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.75950938 |
| 33 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.73842144 |
| 34 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.73842144 |
| 35 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.73842144 |
| 36 | nucleoside transmembrane transport (GO:1901642) | 3.73760718 |
| 37 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.71568471 |
| 38 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.71568471 |
| 39 | pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148) | 3.70317214 |
| 40 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.70142295 |
| 41 | protein targeting to mitochondrion (GO:0006626) | 3.69631577 |
| 42 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 3.69233711 |
| 43 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.68745588 |
| 44 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 3.68601501 |
| 45 | electron transport chain (GO:0022900) | 3.67990505 |
| 46 | respiratory electron transport chain (GO:0022904) | 3.66000655 |
| 47 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 3.57962596 |
| 48 | termination of RNA polymerase I transcription (GO:0006363) | 3.56265251 |
| 49 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.52456876 |
| 50 | negative regulation of ligase activity (GO:0051352) | 3.52456876 |
| 51 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.51390688 |
| 52 | pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209) | 3.48470322 |
| 53 | sulfation (GO:0051923) | 3.48312895 |
| 54 | ribosomal large subunit biogenesis (GO:0042273) | 3.48170661 |
| 55 | intracellular protein transmembrane import (GO:0044743) | 3.47227171 |
| 56 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.45681936 |
| 57 | protein localization to mitochondrion (GO:0070585) | 3.44281860 |
| 58 | protein maturation by protein folding (GO:0022417) | 3.43605662 |
| 59 | establishment of protein localization to mitochondrion (GO:0072655) | 3.34709931 |
| 60 | atrial cardiac muscle cell action potential (GO:0086014) | 3.33262205 |
| 61 | ribonucleoside triphosphate biosynthetic process (GO:0009201) | 3.32422942 |
| 62 | pyrimidine nucleoside triphosphate metabolic process (GO:0009147) | 3.31660860 |
| 63 | regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) | 3.31182105 |
| 64 | ATP biosynthetic process (GO:0006754) | 3.24821551 |
| 65 | pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208) | 3.23173642 |
| 66 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.20946149 |
| 67 | interferon-gamma secretion (GO:0072643) | 3.20646453 |
| 68 | cullin deneddylation (GO:0010388) | 3.20164144 |
| 69 | transcription from RNA polymerase I promoter (GO:0006360) | 3.18957754 |
| 70 | translation (GO:0006412) | 3.12519950 |
| 71 | cellular response to interferon-beta (GO:0035458) | 3.08568563 |
| 72 | positive regulation of ligase activity (GO:0051351) | 3.08481713 |
| 73 | GDP-mannose metabolic process (GO:0019673) | 3.07327577 |
| 74 | negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471) | 3.07053844 |
| 75 | nucleoside triphosphate biosynthetic process (GO:0009142) | 3.05560974 |
| 76 | cellular component biogenesis (GO:0044085) | 3.05254953 |
| 77 | water-soluble vitamin biosynthetic process (GO:0042364) | 3.05026049 |
| 78 | nucleoside diphosphate phosphorylation (GO:0006165) | 3.05016901 |
| 79 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 3.01410550 |
| 80 | cytidine metabolic process (GO:0046087) | 2.99097448 |
| 81 | cytidine catabolic process (GO:0006216) | 2.99097448 |
| 82 | cytidine deamination (GO:0009972) | 2.99097448 |
| 83 | response to interferon-beta (GO:0035456) | 2.98550378 |
| 84 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 2.94049452 |
| 85 | maturation of SSU-rRNA (GO:0030490) | 2.91771586 |
| 86 | retina homeostasis (GO:0001895) | 2.90154192 |
| 87 | maturation of 5.8S rRNA (GO:0000460) | 2.90115943 |
| 88 | positive regulation of cell cycle arrest (GO:0071158) | 2.87603088 |
| 89 | detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580) | 2.87339870 |
| 90 | rRNA processing (GO:0006364) | 2.86980544 |
| 91 | mitotic nuclear envelope reassembly (GO:0007084) | 2.86759757 |
| 92 | nuclear envelope reassembly (GO:0031468) | 2.86759757 |
| 93 | transcription initiation from RNA polymerase I promoter (GO:0006361) | 2.86677795 |
| 94 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 2.85549228 |
| 95 | 7-methylguanosine mRNA capping (GO:0006370) | 2.82943996 |
| 96 | endothelial tube morphogenesis (GO:0061154) | 2.82492268 |
| 97 | morphogenesis of an endothelium (GO:0003159) | 2.82492268 |
| 98 | protein deneddylation (GO:0000338) | 2.80736890 |
| 99 | nucleoside transport (GO:0015858) | 2.80583675 |
| 100 | positive regulation of defense response to virus by host (GO:0002230) | 2.79448232 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 5.26627863 |
| 2 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.71538162 |
| 3 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 4.30792206 |
| 4 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 4.30656403 |
| 5 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 4.23293090 |
| 6 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.71267870 |
| 7 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 3.60966148 |
| 8 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.38504171 |
| 9 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 3.27673007 |
| 10 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.02791231 |
| 11 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 3.00606382 |
| 12 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.95076663 |
| 13 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.89863704 |
| 14 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.85729192 |
| 15 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 2.85370783 |
| 16 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 2.84786526 |
| 17 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.84400402 |
| 18 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.72334879 |
| 19 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 2.60027073 |
| 20 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.52336815 |
| 21 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.51756230 |
| 22 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.42771106 |
| 23 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.40531391 |
| 24 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.39884202 |
| 25 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.32017093 |
| 26 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.27362343 |
| 27 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.25365041 |
| 28 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.10893950 |
| 29 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.09651662 |
| 30 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.04473231 |
| 31 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.03578918 |
| 32 | TTF2_22483619_ChIP-Seq_HELA_Human | 2.00857621 |
| 33 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 2.00621211 |
| 34 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.86183008 |
| 35 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.84663127 |
| 36 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.74070926 |
| 37 | VDR_22108803_ChIP-Seq_LS180_Human | 1.73316979 |
| 38 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.71798800 |
| 39 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.62826023 |
| 40 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.60420937 |
| 41 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.56081922 |
| 42 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.55716107 |
| 43 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.53420242 |
| 44 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.50876480 |
| 45 | ATF3_23680149_ChIP-Seq_GBM1-GSC_Human | 1.49490156 |
| 46 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.47990090 |
| 47 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.42519100 |
| 48 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.41825247 |
| 49 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.37583260 |
| 50 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.35723817 |
| 51 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.32424545 |
| 52 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.30765813 |
| 53 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.28360753 |
| 54 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.27808061 |
| 55 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.27034042 |
| 56 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 1.24186542 |
| 57 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.23166831 |
| 58 | CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse | 1.22344668 |
| 59 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.19946431 |
| 60 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.19848714 |
| 61 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.17943248 |
| 62 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.16768165 |
| 63 | ELF5_23300383_ChIP-Seq_T47D_Human | 1.15978049 |
| 64 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.11716467 |
| 65 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 1.11641265 |
| 66 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.09521164 |
| 67 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.07658730 |
| 68 | HIF1A_21447827_ChIP-Seq_MCF-7_Human | 1.07620461 |
| 69 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 1.07213043 |
| 70 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 1.07174900 |
| 71 | FOXP1_21924763_ChIP-Seq_HESCs_Human | 1.04034416 |
| 72 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.03758973 |
| 73 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.03356858 |
| 74 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.00312474 |
| 75 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 1.00271706 |
| 76 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 0.98593691 |
| 77 | TP53_22573176_ChIP-Seq_HFKS_Human | 0.96778048 |
| 78 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 0.96495091 |
| 79 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 0.93982128 |
| 80 | LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.93356947 |
| 81 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 0.92857935 |
| 82 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 0.91557269 |
| 83 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 0.91323949 |
| 84 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 0.91234463 |
| 85 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.88580709 |
| 86 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 0.86695664 |
| 87 | CIITA_25753668_ChIP-Seq_RAJI_Human | 0.84514883 |
| 88 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 0.83682003 |
| 89 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.82456226 |
| 90 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 0.81933727 |
| 91 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.80367229 |
| 92 | SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human | 0.78506537 |
| 93 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 0.78188767 |
| 94 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.77903905 |
| 95 | STAT1_20625510_ChIP-Seq_HELA_Human | 0.77665394 |
| 96 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.77563340 |
| 97 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 0.77399106 |
| 98 | RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 0.76659100 |
| 99 | ERG_20517297_ChIP-Seq_VCAP_Human | 0.76348525 |
| 100 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 0.76196145 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0010368_abnormal_lymphatic_system | 3.11590923 |
| 2 | MP0002736_abnormal_nociception_after | 2.74577028 |
| 3 | MP0005083_abnormal_biliary_tract | 2.64921111 |
| 4 | MP0010030_abnormal_orbit_morphology | 2.58942557 |
| 5 | MP0001968_abnormal_touch/_nociception | 2.49000652 |
| 6 | MP0001879_abnormal_lymphatic_vessel | 2.23267901 |
| 7 | MP0004957_abnormal_blastocyst_morpholog | 2.21340558 |
| 8 | MP0003786_premature_aging | 2.18525569 |
| 9 | MP0005084_abnormal_gallbladder_morpholo | 2.16967641 |
| 10 | MP0004142_abnormal_muscle_tone | 2.13274400 |
| 11 | MP0005165_increased_susceptibility_to | 2.12522437 |
| 12 | MP0004885_abnormal_endolymph | 2.09652874 |
| 13 | MP0003186_abnormal_redox_activity | 2.03027319 |
| 14 | MP0003693_abnormal_embryo_hatching | 2.00551705 |
| 15 | MP0006035_abnormal_mitochondrial_morpho | 2.00430127 |
| 16 | MP0003718_maternal_effect | 1.99933323 |
| 17 | MP0004145_abnormal_muscle_electrophysio | 1.94921545 |
| 18 | MP0008775_abnormal_heart_ventricle | 1.93339451 |
| 19 | MP0006072_abnormal_retinal_apoptosis | 1.92937532 |
| 20 | MP0000685_abnormal_immune_system | 1.85744836 |
| 21 | MP0009780_abnormal_chondrocyte_physiolo | 1.79654081 |
| 22 | MP0004133_heterotaxia | 1.78338350 |
| 23 | MP0009046_muscle_twitch | 1.75259695 |
| 24 | MP0004147_increased_porphyrin_level | 1.74869926 |
| 25 | MP0008058_abnormal_DNA_repair | 1.71019572 |
| 26 | MP0003123_paternal_imprinting | 1.66211120 |
| 27 | MP0008877_abnormal_DNA_methylation | 1.65946319 |
| 28 | MP0000749_muscle_degeneration | 1.62868482 |
| 29 | MP0008872_abnormal_physiological_respon | 1.62569202 |
| 30 | MP0000750_abnormal_muscle_regeneration | 1.60999371 |
| 31 | MP0001529_abnormal_vocalization | 1.59601922 |
| 32 | MP0009745_abnormal_behavioral_response | 1.59446046 |
| 33 | MP0003646_muscle_fatigue | 1.57061331 |
| 34 | MP0002272_abnormal_nervous_system | 1.52474583 |
| 35 | MP0003806_abnormal_nucleotide_metabolis | 1.50728861 |
| 36 | MP0008875_abnormal_xenobiotic_pharmacok | 1.48669677 |
| 37 | MP0004272_abnormal_basement_membrane | 1.48128816 |
| 38 | MP0005365_abnormal_bile_salt | 1.45682377 |
| 39 | MP0003011_delayed_dark_adaptation | 1.44281307 |
| 40 | MP0002282_abnormal_trachea_morphology | 1.38317978 |
| 41 | MP0008007_abnormal_cellular_replicative | 1.37011555 |
| 42 | MP0009379_abnormal_foot_pigmentation | 1.36983295 |
| 43 | MP0000013_abnormal_adipose_tissue | 1.35325059 |
| 44 | MP0005330_cardiomyopathy | 1.32965214 |
| 45 | MP0003077_abnormal_cell_cycle | 1.27119794 |
| 46 | MP0000613_abnormal_salivary_gland | 1.27051072 |
| 47 | MP0000358_abnormal_cell_content/ | 1.25880768 |
| 48 | MP0002837_dystrophic_cardiac_calcinosis | 1.24677169 |
| 49 | MP0003137_abnormal_impulse_conducting | 1.20564780 |
| 50 | MP0003638_abnormal_response/metabolism_ | 1.19240580 |
| 51 | MP0006036_abnormal_mitochondrial_physio | 1.18915572 |
| 52 | MP0003567_abnormal_fetal_cardiomyocyte | 1.18813933 |
| 53 | MP0001905_abnormal_dopamine_level | 1.17963343 |
| 54 | MP0002067_abnormal_sensory_capabilities | 1.17869160 |
| 55 | MP0005595_abnormal_vascular_smooth | 1.16544902 |
| 56 | MP0003878_abnormal_ear_physiology | 1.15861586 |
| 57 | MP0005377_hearing/vestibular/ear_phenot | 1.15861586 |
| 58 | MP0000647_abnormal_sebaceous_gland | 1.15119688 |
| 59 | MP0009697_abnormal_copulation | 1.11584679 |
| 60 | MP0005167_abnormal_blood-brain_barrier | 1.10196642 |
| 61 | MP0002277_abnormal_respiratory_mucosa | 1.09224758 |
| 62 | MP0003329_amyloid_beta_deposits | 1.06526123 |
| 63 | MP0009250_abnormal_appendicular_skeleto | 1.05009371 |
| 64 | MP0008932_abnormal_embryonic_tissue | 1.02705706 |
| 65 | MP0003959_abnormal_lean_body | 0.99687856 |
| 66 | MP0002160_abnormal_reproductive_system | 0.99146408 |
| 67 | MP0005620_abnormal_muscle_contractility | 0.97255113 |
| 68 | MP0002733_abnormal_thermal_nociception | 0.97147281 |
| 69 | MP0009333_abnormal_splenocyte_physiolog | 0.96386881 |
| 70 | MP0003119_abnormal_digestive_system | 0.96090952 |
| 71 | MP0002102_abnormal_ear_morphology | 0.95502035 |
| 72 | MP0003937_abnormal_limbs/digits/tail_de | 0.95443783 |
| 73 | MP0000747_muscle_weakness | 0.94547926 |
| 74 | MP0000049_abnormal_middle_ear | 0.93654102 |
| 75 | MP0005389_reproductive_system_phenotype | 0.89569706 |
| 76 | MP0004019_abnormal_vitamin_homeostasis | 0.89322060 |
| 77 | MP0002210_abnormal_sex_determination | 0.88277516 |
| 78 | MP0002332_abnormal_exercise_endurance | 0.86954767 |
| 79 | MP0002089_abnormal_postnatal_growth/wei | 0.84699525 |
| 80 | MP0002106_abnormal_muscle_physiology | 0.84332091 |
| 81 | MP0002064_seizures | 0.80351047 |
| 82 | MP0000026_abnormal_inner_ear | 0.79971337 |
| 83 | MP0004264_abnormal_extraembryonic_tissu | 0.79209887 |
| 84 | MP0001486_abnormal_startle_reflex | 0.78857437 |
| 85 | MP0002932_abnormal_joint_morphology | 0.78554294 |
| 86 | MP0005584_abnormal_enzyme/coenzyme_acti | 0.74214506 |
| 87 | MP0001542_abnormal_bone_strength | 0.73459116 |
| 88 | MP0004742_abnormal_vestibular_system | 0.73451863 |
| 89 | MP0002184_abnormal_innervation | 0.72981040 |
| 90 | MP0000537_abnormal_urethra_morphology | 0.72974639 |
| 91 | MP0002938_white_spotting | 0.72874798 |
| 92 | MP0001970_abnormal_pain_threshold | 0.72433426 |
| 93 | MP0006054_spinal_hemorrhage | 0.71701991 |
| 94 | MP0001293_anophthalmia | 0.70493823 |
| 95 | MP0005551_abnormal_eye_electrophysiolog | 0.70340485 |
| 96 | MP0000163_abnormal_cartilage_morphology | 0.70212559 |
| 97 | MP0010094_abnormal_chromosome_stability | 0.69894209 |
| 98 | MP0005085_abnormal_gallbladder_physiolo | 0.69729409 |
| 99 | MP0000230_abnormal_systemic_arterial | 0.67369868 |
| 100 | MP0004036_abnormal_muscle_relaxation | 0.66784676 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 4.51774258 |
| 2 | Mitochondrial inheritance (HP:0001427) | 4.45908458 |
| 3 | Hepatocellular necrosis (HP:0001404) | 4.36965380 |
| 4 | Increased CSF lactate (HP:0002490) | 4.23689924 |
| 5 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.89688981 |
| 6 | Hepatic necrosis (HP:0002605) | 3.87141617 |
| 7 | Conjunctival hamartoma (HP:0100780) | 3.83344721 |
| 8 | Acute encephalopathy (HP:0006846) | 3.75074814 |
| 9 | Progressive macrocephaly (HP:0004481) | 3.70004674 |
| 10 | Congenital, generalized hypertrichosis (HP:0004540) | 3.68241026 |
| 11 | Increased serum pyruvate (HP:0003542) | 3.53528111 |
| 12 | Oral leukoplakia (HP:0002745) | 3.33511070 |
| 13 | Opisthotonus (HP:0002179) | 3.17151360 |
| 14 | Abnormality of glycolysis (HP:0004366) | 3.13440676 |
| 15 | Abnormality of alanine metabolism (HP:0010916) | 3.01163712 |
| 16 | Hyperalaninemia (HP:0003348) | 3.01163712 |
| 17 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 3.01163712 |
| 18 | Increased serum lactate (HP:0002151) | 2.97030067 |
| 19 | Increased hepatocellular lipid droplets (HP:0006565) | 2.92712519 |
| 20 | Lipid accumulation in hepatocytes (HP:0006561) | 2.85028998 |
| 21 | Hypoplastic pelvis (HP:0008839) | 2.77778434 |
| 22 | Cerebral edema (HP:0002181) | 2.77020184 |
| 23 | Rough bone trabeculation (HP:0100670) | 2.73875221 |
| 24 | Optic disc pallor (HP:0000543) | 2.71080283 |
| 25 | Increased IgM level (HP:0003496) | 2.69775318 |
| 26 | Stomatitis (HP:0010280) | 2.65938788 |
| 27 | Reduced subcutaneous adipose tissue (HP:0003758) | 2.63926387 |
| 28 | Abnormality of the phalanges of the 2nd finger (HP:0009541) | 2.62853518 |
| 29 | Elevated erythrocyte sedimentation rate (HP:0003565) | 2.60548978 |
| 30 | Lactic acidosis (HP:0003128) | 2.57053839 |
| 31 | Renal Fanconi syndrome (HP:0001994) | 2.51817102 |
| 32 | Adactyly (HP:0009776) | 2.50221002 |
| 33 | Abnormal number of erythroid precursors (HP:0012131) | 2.49234424 |
| 34 | Type I transferrin isoform profile (HP:0003642) | 2.47706381 |
| 35 | Hypokinesia (HP:0002375) | 2.44989249 |
| 36 | Leukodystrophy (HP:0002415) | 2.38267310 |
| 37 | 3-Methylglutaconic aciduria (HP:0003535) | 2.36866180 |
| 38 | Adrenal hypoplasia (HP:0000835) | 2.36712256 |
| 39 | Respiratory failure (HP:0002878) | 2.35583349 |
| 40 | Hypoplasia of the uterus (HP:0000013) | 2.34707332 |
| 41 | Delayed CNS myelination (HP:0002188) | 2.34507753 |
| 42 | Testicular atrophy (HP:0000029) | 2.33457058 |
| 43 | Exertional dyspnea (HP:0002875) | 2.24722991 |
| 44 | Palpebral edema (HP:0100540) | 2.23383581 |
| 45 | Gliosis (HP:0002171) | 2.18254427 |
| 46 | Short femoral neck (HP:0100864) | 2.17979996 |
| 47 | CNS demyelination (HP:0007305) | 2.15745547 |
| 48 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 2.14439701 |
| 49 | Colon cancer (HP:0003003) | 2.13530340 |
| 50 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.13416688 |
| 51 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.13416688 |
| 52 | Abnormal protein glycosylation (HP:0012346) | 2.13416688 |
| 53 | Abnormal glycosylation (HP:0012345) | 2.13416688 |
| 54 | Aplasia/hypoplasia of the uterus (HP:0008684) | 2.11377640 |
| 55 | Methylmalonic aciduria (HP:0012120) | 2.10456119 |
| 56 | Abnormality of placental membranes (HP:0011409) | 2.07296004 |
| 57 | Amniotic constriction ring (HP:0009775) | 2.07296004 |
| 58 | Exercise intolerance (HP:0003546) | 2.07290494 |
| 59 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.06660852 |
| 60 | Abnormality of cells of the erythroid lineage (HP:0012130) | 2.05375192 |
| 61 | Multiple lipomas (HP:0001012) | 2.04562286 |
| 62 | Large for gestational age (HP:0001520) | 2.03268732 |
| 63 | Severe muscular hypotonia (HP:0006829) | 2.01610401 |
| 64 | IgG deficiency (HP:0004315) | 2.01603832 |
| 65 | Entropion (HP:0000621) | 2.01230919 |
| 66 | Hypoplasia of the pons (HP:0012110) | 1.95392548 |
| 67 | Furrowed tongue (HP:0000221) | 1.95290057 |
| 68 | Abnormality of the proximal phalanges of the hand (HP:0009834) | 1.94519138 |
| 69 | Abnormal lung lobation (HP:0002101) | 1.92650402 |
| 70 | Abnormality of the middle phalanges of the toes (HP:0010183) | 1.91878928 |
| 71 | Fibular aplasia (HP:0002990) | 1.91689819 |
| 72 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 1.90902171 |
| 73 | Cerebral hypomyelination (HP:0006808) | 1.90648012 |
| 74 | Abnormal trabecular bone morphology (HP:0100671) | 1.89138066 |
| 75 | Progressive microcephaly (HP:0000253) | 1.88834495 |
| 76 | Neoplasm of the adrenal gland (HP:0100631) | 1.88496367 |
| 77 | Lethargy (HP:0001254) | 1.87974883 |
| 78 | Hamartoma of the eye (HP:0010568) | 1.87169927 |
| 79 | Pancytopenia (HP:0001876) | 1.86076844 |
| 80 | Emotional lability (HP:0000712) | 1.85815227 |
| 81 | True hermaphroditism (HP:0010459) | 1.85122728 |
| 82 | Meningioma (HP:0002858) | 1.85001987 |
| 83 | Aplasia involving bones of the upper limbs (HP:0009823) | 1.84451924 |
| 84 | Aplasia of the phalanges of the hand (HP:0009802) | 1.84451924 |
| 85 | Aplasia involving bones of the extremities (HP:0009825) | 1.84451924 |
| 86 | Abnormality of the pons (HP:0007361) | 1.83447152 |
| 87 | Ulnar claw (HP:0001178) | 1.82512113 |
| 88 | Microretrognathia (HP:0000308) | 1.81961322 |
| 89 | Sparse eyelashes (HP:0000653) | 1.81831289 |
| 90 | Aplasia/Hypoplasia involving the pelvis (HP:0009103) | 1.81610183 |
| 91 | Methylmalonic acidemia (HP:0002912) | 1.80426610 |
| 92 | Flat capital femoral epiphysis (HP:0003370) | 1.80366646 |
| 93 | Anophthalmia (HP:0000528) | 1.79553672 |
| 94 | X-linked dominant inheritance (HP:0001423) | 1.79176639 |
| 95 | Neoplasm of the adrenal cortex (HP:0100641) | 1.78486917 |
| 96 | Poor head control (HP:0002421) | 1.78252884 |
| 97 | Congenital ichthyosiform erythroderma (HP:0007431) | 1.78199045 |
| 98 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 1.78161157 |
| 99 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 1.78161157 |
| 100 | Abnormality of renal resorption (HP:0011038) | 1.77497006 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | VRK2 | 6.82932494 |
| 2 | TIE1 | 4.85929746 |
| 3 | NME2 | 3.74355215 |
| 4 | TAF1 | 2.96550031 |
| 5 | NUAK1 | 2.96256635 |
| 6 | BUB1 | 2.92734416 |
| 7 | VRK1 | 2.87304828 |
| 8 | TESK1 | 2.32916337 |
| 9 | TESK2 | 2.24706592 |
| 10 | MST4 | 2.15487481 |
| 11 | LIMK1 | 2.09110704 |
| 12 | STK16 | 1.89058202 |
| 13 | BCKDK | 1.83881018 |
| 14 | EPHA2 | 1.82498548 |
| 15 | PHKG1 | 1.81696401 |
| 16 | PHKG2 | 1.81696401 |
| 17 | PBK | 1.76003495 |
| 18 | CSNK1G3 | 1.62591329 |
| 19 | SMG1 | 1.58240238 |
| 20 | CSNK1A1L | 1.56293086 |
| 21 | KDR | 1.55897879 |
| 22 | ZAK | 1.52467734 |
| 23 | TSSK6 | 1.47533079 |
| 24 | TRIM28 | 1.47081977 |
| 25 | CSNK1G1 | 1.44483230 |
| 26 | DAPK1 | 1.42539855 |
| 27 | EPHB2 | 1.42494068 |
| 28 | GRK1 | 1.38363723 |
| 29 | PDK2 | 1.36075047 |
| 30 | LMTK2 | 1.35805834 |
| 31 | PLK3 | 1.34167287 |
| 32 | SRPK1 | 1.33579179 |
| 33 | DYRK2 | 1.31387511 |
| 34 | ADRBK2 | 1.29664126 |
| 35 | TNIK | 1.27455591 |
| 36 | CSNK1G2 | 1.23956037 |
| 37 | NEK1 | 1.18579126 |
| 38 | GRK5 | 1.04107630 |
| 39 | PIM2 | 1.00371393 |
| 40 | NEK9 | 0.98594996 |
| 41 | MAP2K7 | 0.87075772 |
| 42 | BMPR1B | 0.85524447 |
| 43 | MUSK | 0.84765038 |
| 44 | ABL2 | 0.84296633 |
| 45 | GRK7 | 0.83511315 |
| 46 | ARAF | 0.81112649 |
| 47 | TLK1 | 0.75616194 |
| 48 | AURKA | 0.75124976 |
| 49 | PINK1 | 0.71733284 |
| 50 | NME1 | 0.70144763 |
| 51 | BLK | 0.67673413 |
| 52 | PTK2B | 0.67552686 |
| 53 | ILK | 0.64894756 |
| 54 | CDK8 | 0.64293028 |
| 55 | EIF2AK2 | 0.64165565 |
| 56 | PRKCI | 0.62382442 |
| 57 | TAOK2 | 0.61913900 |
| 58 | CCNB1 | 0.61773830 |
| 59 | EIF2AK3 | 0.60381459 |
| 60 | DAPK3 | 0.60322072 |
| 61 | RPS6KA5 | 0.59900304 |
| 62 | PAK4 | 0.59843239 |
| 63 | EIF2AK1 | 0.58116191 |
| 64 | MAP3K12 | 0.57257535 |
| 65 | DAPK2 | 0.54718272 |
| 66 | MAPKAPK5 | 0.51300903 |
| 67 | HIPK2 | 0.50645621 |
| 68 | INSRR | 0.48222262 |
| 69 | ADRBK1 | 0.46882503 |
| 70 | CDC7 | 0.46209021 |
| 71 | MAPKAPK3 | 0.45675979 |
| 72 | FGFR1 | 0.45530528 |
| 73 | MAP2K6 | 0.45269867 |
| 74 | IKBKB | 0.45196750 |
| 75 | OXSR1 | 0.41106619 |
| 76 | STK39 | 0.40982433 |
| 77 | MAP3K11 | 0.40624081 |
| 78 | PLK1 | 0.40386743 |
| 79 | CDK19 | 0.39753639 |
| 80 | IRAK3 | 0.39604035 |
| 81 | TEC | 0.36372515 |
| 82 | CDK7 | 0.34638243 |
| 83 | CSNK1A1 | 0.34519285 |
| 84 | CHEK2 | 0.30840841 |
| 85 | CSNK2A2 | 0.30391423 |
| 86 | CSNK2A1 | 0.30005219 |
| 87 | BCR | 0.26934980 |
| 88 | CAMK2G | 0.25839099 |
| 89 | CAMKK2 | 0.24138670 |
| 90 | ATR | 0.23785942 |
| 91 | STK4 | 0.23288550 |
| 92 | MARK1 | 0.21856851 |
| 93 | MET | 0.21331701 |
| 94 | AURKB | 0.20353194 |
| 95 | PRKCG | 0.19768625 |
| 96 | IKBKE | 0.18061626 |
| 97 | CAMK4 | 0.17724777 |
| 98 | PLK4 | 0.17303703 |
| 99 | MAP3K8 | 0.16150278 |
| 100 | GSK3A | 0.16020517 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 5.15625572 |
| 2 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 4.01207282 |
| 3 | Ribosome_Homo sapiens_hsa03010 | 3.77783004 |
| 4 | Parkinsons disease_Homo sapiens_hsa05012 | 3.27414528 |
| 5 | Sulfur relay system_Homo sapiens_hsa04122 | 3.10765388 |
| 6 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.98476209 |
| 7 | RNA polymerase_Homo sapiens_hsa03020 | 2.80857405 |
| 8 | Huntingtons disease_Homo sapiens_hsa05016 | 2.53978713 |
| 9 | Alzheimers disease_Homo sapiens_hsa05010 | 2.39106738 |
| 10 | Protein export_Homo sapiens_hsa03060 | 2.08727088 |
| 11 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.91018563 |
| 12 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.88680871 |
| 13 | Homologous recombination_Homo sapiens_hsa03440 | 1.82169971 |
| 14 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.78363988 |
| 15 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.77823353 |
| 16 | DNA replication_Homo sapiens_hsa03030 | 1.76947501 |
| 17 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 1.72052428 |
| 18 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.71810851 |
| 19 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.61651134 |
| 20 | Basal transcription factors_Homo sapiens_hsa03022 | 1.57021894 |
| 21 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.56928522 |
| 22 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.55808939 |
| 23 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.47982332 |
| 24 | Base excision repair_Homo sapiens_hsa03410 | 1.47685190 |
| 25 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.42688218 |
| 26 | RNA degradation_Homo sapiens_hsa03018 | 1.41279006 |
| 27 | Mismatch repair_Homo sapiens_hsa03430 | 1.38833484 |
| 28 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.34077182 |
| 29 | Purine metabolism_Homo sapiens_hsa00230 | 1.31160149 |
| 30 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.28666913 |
| 31 | RNA transport_Homo sapiens_hsa03013 | 1.26708086 |
| 32 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.26472737 |
| 33 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.19951500 |
| 34 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 1.11633019 |
| 35 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.04881964 |
| 36 | Peroxisome_Homo sapiens_hsa04146 | 1.04752369 |
| 37 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 1.02130584 |
| 38 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 1.01625197 |
| 39 | Spliceosome_Homo sapiens_hsa03040 | 1.00563388 |
| 40 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.96593143 |
| 41 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.94523555 |
| 42 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.91178515 |
| 43 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.90910076 |
| 44 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.89543092 |
| 45 | Carbon metabolism_Homo sapiens_hsa01200 | 0.88517654 |
| 46 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.85395763 |
| 47 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.84640701 |
| 48 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.81061155 |
| 49 | Metabolic pathways_Homo sapiens_hsa01100 | 0.78405222 |
| 50 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.77815024 |
| 51 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.76638902 |
| 52 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.75854373 |
| 53 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.75744083 |
| 54 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.75592494 |
| 55 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.75086897 |
| 56 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.73640534 |
| 57 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.73435703 |
| 58 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.70819915 |
| 59 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.70220566 |
| 60 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.68772657 |
| 61 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.66401226 |
| 62 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.66218957 |
| 63 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.64357420 |
| 64 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.62969978 |
| 65 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.62673714 |
| 66 | Salivary secretion_Homo sapiens_hsa04970 | 0.62445952 |
| 67 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.61783375 |
| 68 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.59958292 |
| 69 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.58718337 |
| 70 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.58590846 |
| 71 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.54146626 |
| 72 | Nicotine addiction_Homo sapiens_hsa05033 | 0.50124518 |
| 73 | Galactose metabolism_Homo sapiens_hsa00052 | 0.49872359 |
| 74 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.49005639 |
| 75 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.48580727 |
| 76 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.46168331 |
| 77 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.45426146 |
| 78 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.44988194 |
| 79 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.42170813 |
| 80 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.39112856 |
| 81 | Mineral absorption_Homo sapiens_hsa04978 | 0.36709421 |
| 82 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.36037524 |
| 83 | Retinol metabolism_Homo sapiens_hsa00830 | 0.35709554 |
| 84 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.35243637 |
| 85 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.32052724 |
| 86 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.30657617 |
| 87 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.30584701 |
| 88 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.29345039 |
| 89 | Morphine addiction_Homo sapiens_hsa05032 | 0.29124280 |
| 90 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.28143416 |
| 91 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.26615574 |
| 92 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.25544152 |
| 93 | Insulin secretion_Homo sapiens_hsa04911 | 0.24752439 |
| 94 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.20534252 |
| 95 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.18087369 |
| 96 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.16791885 |
| 97 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.15857621 |
| 98 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.15801163 |
| 99 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.15465275 |
| 100 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.14716775 |

