GAPDHP29

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of protein localization to mitochondrial membrane (GO:0090151)6.15987590
2proteasome assembly (GO:0043248)6.06830025
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.72666996
4DNA deamination (GO:0045006)5.36225250
5ATP synthesis coupled proton transport (GO:0015986)5.35725340
6energy coupled proton transport, down electrochemical gradient (GO:0015985)5.35725340
7GTP biosynthetic process (GO:0006183)5.09872216
8mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.92344580
9mitochondrial respiratory chain complex I assembly (GO:0032981)4.92344580
10NADH dehydrogenase complex assembly (GO:0010257)4.92344580
11rRNA modification (GO:0000154)4.71539134
12protein complex biogenesis (GO:0070271)4.67535537
13UTP biosynthetic process (GO:0006228)4.59523141
14chaperone-mediated protein transport (GO:0072321)4.52605331
15mitochondrial respiratory chain complex assembly (GO:0033108)4.40443093
16guanosine-containing compound biosynthetic process (GO:1901070)4.17919603
17UTP metabolic process (GO:0046051)4.17259588
18rRNA methylation (GO:0031167)4.11283942
19negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.99926978
20transcription elongation from RNA polymerase I promoter (GO:0006362)3.99449966
21mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.86142802
22DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.85286574
23termination of RNA polymerase III transcription (GO:0006386)3.84409238
24transcription elongation from RNA polymerase III promoter (GO:0006385)3.84409238
25establishment of integrated proviral latency (GO:0075713)3.84018471
26pseudouridine synthesis (GO:0001522)3.82980104
27establishment of viral latency (GO:0019043)3.81590226
28CTP metabolic process (GO:0046036)3.77478327
29CTP biosynthetic process (GO:0006241)3.77478327
30positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.76663230
31signal transduction involved in DNA integrity checkpoint (GO:0072401)3.75950938
32signal transduction involved in DNA damage checkpoint (GO:0072422)3.75950938
33signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.73842144
34signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.73842144
35signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.73842144
36nucleoside transmembrane transport (GO:1901642)3.73760718
37intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.71568471
38signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.71568471
39pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.70317214
40regulation of cellular amino acid metabolic process (GO:0006521)3.70142295
41protein targeting to mitochondrion (GO:0006626)3.69631577
42purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.69233711
43signal transduction involved in cell cycle checkpoint (GO:0072395)3.68745588
44purine nucleoside triphosphate biosynthetic process (GO:0009145)3.68601501
45electron transport chain (GO:0022900)3.67990505
46respiratory electron transport chain (GO:0022904)3.66000655
47regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.57962596
48termination of RNA polymerase I transcription (GO:0006363)3.56265251
49negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.52456876
50negative regulation of ligase activity (GO:0051352)3.52456876
51regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.51390688
52pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.48470322
53sulfation (GO:0051923)3.48312895
54ribosomal large subunit biogenesis (GO:0042273)3.48170661
55intracellular protein transmembrane import (GO:0044743)3.47227171
56anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.45681936
57protein localization to mitochondrion (GO:0070585)3.44281860
58protein maturation by protein folding (GO:0022417)3.43605662
59establishment of protein localization to mitochondrion (GO:0072655)3.34709931
60atrial cardiac muscle cell action potential (GO:0086014)3.33262205
61ribonucleoside triphosphate biosynthetic process (GO:0009201)3.32422942
62pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.31660860
63regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.31182105
64ATP biosynthetic process (GO:0006754)3.24821551
65pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.23173642
66positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.20946149
67interferon-gamma secretion (GO:0072643)3.20646453
68cullin deneddylation (GO:0010388)3.20164144
69transcription from RNA polymerase I promoter (GO:0006360)3.18957754
70translation (GO:0006412)3.12519950
71cellular response to interferon-beta (GO:0035458)3.08568563
72positive regulation of ligase activity (GO:0051351)3.08481713
73GDP-mannose metabolic process (GO:0019673)3.07327577
74negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.07053844
75nucleoside triphosphate biosynthetic process (GO:0009142)3.05560974
76cellular component biogenesis (GO:0044085)3.05254953
77water-soluble vitamin biosynthetic process (GO:0042364)3.05026049
78nucleoside diphosphate phosphorylation (GO:0006165)3.05016901
79DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.01410550
80cytidine metabolic process (GO:0046087)2.99097448
81cytidine catabolic process (GO:0006216)2.99097448
82cytidine deamination (GO:0009972)2.99097448
83response to interferon-beta (GO:0035456)2.98550378
84nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.94049452
85maturation of SSU-rRNA (GO:0030490)2.91771586
86retina homeostasis (GO:0001895)2.90154192
87maturation of 5.8S rRNA (GO:0000460)2.90115943
88positive regulation of cell cycle arrest (GO:0071158)2.87603088
89detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)2.87339870
90rRNA processing (GO:0006364)2.86980544
91mitotic nuclear envelope reassembly (GO:0007084)2.86759757
92nuclear envelope reassembly (GO:0031468)2.86759757
93transcription initiation from RNA polymerase I promoter (GO:0006361)2.86677795
94exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.85549228
957-methylguanosine mRNA capping (GO:0006370)2.82943996
96endothelial tube morphogenesis (GO:0061154)2.82492268
97morphogenesis of an endothelium (GO:0003159)2.82492268
98protein deneddylation (GO:0000338)2.80736890
99nucleoside transport (GO:0015858)2.80583675
100positive regulation of defense response to virus by host (GO:0002230)2.79448232

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.26627863
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.71538162
3EST1_17652178_ChIP-ChIP_JURKAT_Human4.30792206
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.30656403
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.23293090
6ETS1_20019798_ChIP-Seq_JURKAT_Human3.71267870
7HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.60966148
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.38504171
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.27673007
10CREB1_15753290_ChIP-ChIP_HEK293T_Human3.02791231
11CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.00606382
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.95076663
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.89863704
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.85729192
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.85370783
16YY1_21170310_ChIP-Seq_MESCs_Mouse2.84786526
17SRF_21415370_ChIP-Seq_HL-1_Mouse2.84400402
18MYC_18358816_ChIP-ChIP_MESCs_Mouse2.72334879
19EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.60027073
20VDR_23849224_ChIP-Seq_CD4+_Human2.52336815
21THAP11_20581084_ChIP-Seq_MESCs_Mouse2.51756230
22ELK1_19687146_ChIP-ChIP_HELA_Human2.42771106
23PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.40531391
24FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.39884202
25FOXP3_21729870_ChIP-Seq_TREG_Human2.32017093
26MYC_19079543_ChIP-ChIP_MESCs_Mouse2.27362343
27DCP1A_22483619_ChIP-Seq_HELA_Human2.25365041
28XRN2_22483619_ChIP-Seq_HELA_Human2.10893950
29E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.09651662
30MYC_19030024_ChIP-ChIP_MESCs_Mouse2.04473231
31E2F1_18555785_ChIP-Seq_MESCs_Mouse2.03578918
32TTF2_22483619_ChIP-Seq_HELA_Human2.00857621
33CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.00621211
34ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.86183008
35GABP_19822575_ChIP-Seq_HepG2_Human1.84663127
36ELK1_22589737_ChIP-Seq_MCF10A_Human1.74070926
37VDR_22108803_ChIP-Seq_LS180_Human1.73316979
38NELFA_20434984_ChIP-Seq_ESCs_Mouse1.71798800
39CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.62826023
40TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.60420937
41HOXB4_20404135_ChIP-ChIP_EML_Mouse1.56081922
42E2F4_17652178_ChIP-ChIP_JURKAT_Human1.55716107
43PADI4_21655091_ChIP-ChIP_MCF-7_Human1.53420242
44BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.50876480
45ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.49490156
46CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.47990090
47ZNF274_21170338_ChIP-Seq_K562_Hela1.42519100
48CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.41825247
49FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.37583260
50MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.35723817
51TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32424545
52FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.30765813
53POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.28360753
54DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.27808061
55POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.27034042
56CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.24186542
57HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.23166831
58CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.22344668
59KDM5A_27292631_Chip-Seq_BREAST_Human1.19946431
60PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19848714
61MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.17943248
62MYC_18940864_ChIP-ChIP_HL60_Human1.16768165
63ELF5_23300383_ChIP-Seq_T47D_Human1.15978049
64SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.11716467
65CTCF_18555785_ChIP-Seq_MESCs_Mouse1.11641265
66NANOG_18555785_ChIP-Seq_MESCs_Mouse1.09521164
67ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.07658730
68HIF1A_21447827_ChIP-Seq_MCF-7_Human1.07620461
69PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.07213043
70YY1_22570637_ChIP-Seq_MALME-3M_Human1.07174900
71FOXP1_21924763_ChIP-Seq_HESCs_Human1.04034416
72KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.03758973
73TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.03356858
74IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.00312474
75EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.00271706
76YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.98593691
77TP53_22573176_ChIP-Seq_HFKS_Human0.96778048
78MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.96495091
79TET1_21451524_ChIP-Seq_MESCs_Mouse0.93982128
80LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93356947
81PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.92857935
82POU5F1_16153702_ChIP-ChIP_HESCs_Human0.91557269
83NOTCH1_21737748_ChIP-Seq_TLL_Human0.91323949
84TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.91234463
85CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.88580709
86NANOG_16153702_ChIP-ChIP_HESCs_Human0.86695664
87CIITA_25753668_ChIP-Seq_RAJI_Human0.84514883
88EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.83682003
89SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.82456226
90NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.81933727
91SOX2_16153702_ChIP-ChIP_HESCs_Human0.80367229
92SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.78506537
93EGR1_23403033_ChIP-Seq_LIVER_Mouse0.78188767
94FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77903905
95STAT1_20625510_ChIP-Seq_HELA_Human0.77665394
96E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.77563340
97STAT4_19710469_ChIP-ChIP_TH1__Mouse0.77399106
98RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.76659100
99ERG_20517297_ChIP-Seq_VCAP_Human0.76348525
100PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.76196145

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010368_abnormal_lymphatic_system3.11590923
2MP0002736_abnormal_nociception_after2.74577028
3MP0005083_abnormal_biliary_tract2.64921111
4MP0010030_abnormal_orbit_morphology2.58942557
5MP0001968_abnormal_touch/_nociception2.49000652
6MP0001879_abnormal_lymphatic_vessel2.23267901
7MP0004957_abnormal_blastocyst_morpholog2.21340558
8MP0003786_premature_aging2.18525569
9MP0005084_abnormal_gallbladder_morpholo2.16967641
10MP0004142_abnormal_muscle_tone2.13274400
11MP0005165_increased_susceptibility_to2.12522437
12MP0004885_abnormal_endolymph2.09652874
13MP0003186_abnormal_redox_activity2.03027319
14MP0003693_abnormal_embryo_hatching2.00551705
15MP0006035_abnormal_mitochondrial_morpho2.00430127
16MP0003718_maternal_effect1.99933323
17MP0004145_abnormal_muscle_electrophysio1.94921545
18MP0008775_abnormal_heart_ventricle1.93339451
19MP0006072_abnormal_retinal_apoptosis1.92937532
20MP0000685_abnormal_immune_system1.85744836
21MP0009780_abnormal_chondrocyte_physiolo1.79654081
22MP0004133_heterotaxia1.78338350
23MP0009046_muscle_twitch1.75259695
24MP0004147_increased_porphyrin_level1.74869926
25MP0008058_abnormal_DNA_repair1.71019572
26MP0003123_paternal_imprinting1.66211120
27MP0008877_abnormal_DNA_methylation1.65946319
28MP0000749_muscle_degeneration1.62868482
29MP0008872_abnormal_physiological_respon1.62569202
30MP0000750_abnormal_muscle_regeneration1.60999371
31MP0001529_abnormal_vocalization1.59601922
32MP0009745_abnormal_behavioral_response1.59446046
33MP0003646_muscle_fatigue1.57061331
34MP0002272_abnormal_nervous_system1.52474583
35MP0003806_abnormal_nucleotide_metabolis1.50728861
36MP0008875_abnormal_xenobiotic_pharmacok1.48669677
37MP0004272_abnormal_basement_membrane1.48128816
38MP0005365_abnormal_bile_salt1.45682377
39MP0003011_delayed_dark_adaptation1.44281307
40MP0002282_abnormal_trachea_morphology1.38317978
41MP0008007_abnormal_cellular_replicative1.37011555
42MP0009379_abnormal_foot_pigmentation1.36983295
43MP0000013_abnormal_adipose_tissue1.35325059
44MP0005330_cardiomyopathy1.32965214
45MP0003077_abnormal_cell_cycle1.27119794
46MP0000613_abnormal_salivary_gland1.27051072
47MP0000358_abnormal_cell_content/1.25880768
48MP0002837_dystrophic_cardiac_calcinosis1.24677169
49MP0003137_abnormal_impulse_conducting1.20564780
50MP0003638_abnormal_response/metabolism_1.19240580
51MP0006036_abnormal_mitochondrial_physio1.18915572
52MP0003567_abnormal_fetal_cardiomyocyte1.18813933
53MP0001905_abnormal_dopamine_level1.17963343
54MP0002067_abnormal_sensory_capabilities1.17869160
55MP0005595_abnormal_vascular_smooth1.16544902
56MP0003878_abnormal_ear_physiology1.15861586
57MP0005377_hearing/vestibular/ear_phenot1.15861586
58MP0000647_abnormal_sebaceous_gland1.15119688
59MP0009697_abnormal_copulation1.11584679
60MP0005167_abnormal_blood-brain_barrier1.10196642
61MP0002277_abnormal_respiratory_mucosa1.09224758
62MP0003329_amyloid_beta_deposits1.06526123
63MP0009250_abnormal_appendicular_skeleto1.05009371
64MP0008932_abnormal_embryonic_tissue1.02705706
65MP0003959_abnormal_lean_body0.99687856
66MP0002160_abnormal_reproductive_system0.99146408
67MP0005620_abnormal_muscle_contractility0.97255113
68MP0002733_abnormal_thermal_nociception0.97147281
69MP0009333_abnormal_splenocyte_physiolog0.96386881
70MP0003119_abnormal_digestive_system0.96090952
71MP0002102_abnormal_ear_morphology0.95502035
72MP0003937_abnormal_limbs/digits/tail_de0.95443783
73MP0000747_muscle_weakness0.94547926
74MP0000049_abnormal_middle_ear0.93654102
75MP0005389_reproductive_system_phenotype0.89569706
76MP0004019_abnormal_vitamin_homeostasis0.89322060
77MP0002210_abnormal_sex_determination0.88277516
78MP0002332_abnormal_exercise_endurance0.86954767
79MP0002089_abnormal_postnatal_growth/wei0.84699525
80MP0002106_abnormal_muscle_physiology0.84332091
81MP0002064_seizures0.80351047
82MP0000026_abnormal_inner_ear0.79971337
83MP0004264_abnormal_extraembryonic_tissu0.79209887
84MP0001486_abnormal_startle_reflex0.78857437
85MP0002932_abnormal_joint_morphology0.78554294
86MP0005584_abnormal_enzyme/coenzyme_acti0.74214506
87MP0001542_abnormal_bone_strength0.73459116
88MP0004742_abnormal_vestibular_system0.73451863
89MP0002184_abnormal_innervation0.72981040
90MP0000537_abnormal_urethra_morphology0.72974639
91MP0002938_white_spotting0.72874798
92MP0001970_abnormal_pain_threshold0.72433426
93MP0006054_spinal_hemorrhage0.71701991
94MP0001293_anophthalmia0.70493823
95MP0005551_abnormal_eye_electrophysiolog0.70340485
96MP0000163_abnormal_cartilage_morphology0.70212559
97MP0010094_abnormal_chromosome_stability0.69894209
98MP0005085_abnormal_gallbladder_physiolo0.69729409
99MP0000230_abnormal_systemic_arterial0.67369868
100MP0004036_abnormal_muscle_relaxation0.66784676

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.51774258
2Mitochondrial inheritance (HP:0001427)4.45908458
3Hepatocellular necrosis (HP:0001404)4.36965380
4Increased CSF lactate (HP:0002490)4.23689924
5Abnormal mitochondria in muscle tissue (HP:0008316)3.89688981
6Hepatic necrosis (HP:0002605)3.87141617
7Conjunctival hamartoma (HP:0100780)3.83344721
8Acute encephalopathy (HP:0006846)3.75074814
9Progressive macrocephaly (HP:0004481)3.70004674
10Congenital, generalized hypertrichosis (HP:0004540)3.68241026
11Increased serum pyruvate (HP:0003542)3.53528111
12Oral leukoplakia (HP:0002745)3.33511070
13Opisthotonus (HP:0002179)3.17151360
14Abnormality of glycolysis (HP:0004366)3.13440676
15Abnormality of alanine metabolism (HP:0010916)3.01163712
16Hyperalaninemia (HP:0003348)3.01163712
17Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.01163712
18Increased serum lactate (HP:0002151)2.97030067
19Increased hepatocellular lipid droplets (HP:0006565)2.92712519
20Lipid accumulation in hepatocytes (HP:0006561)2.85028998
21Hypoplastic pelvis (HP:0008839)2.77778434
22Cerebral edema (HP:0002181)2.77020184
23Rough bone trabeculation (HP:0100670)2.73875221
24Optic disc pallor (HP:0000543)2.71080283
25Increased IgM level (HP:0003496)2.69775318
26Stomatitis (HP:0010280)2.65938788
27Reduced subcutaneous adipose tissue (HP:0003758)2.63926387
28Abnormality of the phalanges of the 2nd finger (HP:0009541)2.62853518
29Elevated erythrocyte sedimentation rate (HP:0003565)2.60548978
30Lactic acidosis (HP:0003128)2.57053839
31Renal Fanconi syndrome (HP:0001994)2.51817102
32Adactyly (HP:0009776)2.50221002
33Abnormal number of erythroid precursors (HP:0012131)2.49234424
34Type I transferrin isoform profile (HP:0003642)2.47706381
35Hypokinesia (HP:0002375)2.44989249
36Leukodystrophy (HP:0002415)2.38267310
373-Methylglutaconic aciduria (HP:0003535)2.36866180
38Adrenal hypoplasia (HP:0000835)2.36712256
39Respiratory failure (HP:0002878)2.35583349
40Hypoplasia of the uterus (HP:0000013)2.34707332
41Delayed CNS myelination (HP:0002188)2.34507753
42Testicular atrophy (HP:0000029)2.33457058
43Exertional dyspnea (HP:0002875)2.24722991
44Palpebral edema (HP:0100540)2.23383581
45Gliosis (HP:0002171)2.18254427
46Short femoral neck (HP:0100864)2.17979996
47CNS demyelination (HP:0007305)2.15745547
48Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.14439701
49Colon cancer (HP:0003003)2.13530340
50Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.13416688
51Abnormal protein N-linked glycosylation (HP:0012347)2.13416688
52Abnormal protein glycosylation (HP:0012346)2.13416688
53Abnormal glycosylation (HP:0012345)2.13416688
54Aplasia/hypoplasia of the uterus (HP:0008684)2.11377640
55Methylmalonic aciduria (HP:0012120)2.10456119
56Abnormality of placental membranes (HP:0011409)2.07296004
57Amniotic constriction ring (HP:0009775)2.07296004
58Exercise intolerance (HP:0003546)2.07290494
59Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.06660852
60Abnormality of cells of the erythroid lineage (HP:0012130)2.05375192
61Multiple lipomas (HP:0001012)2.04562286
62Large for gestational age (HP:0001520)2.03268732
63Severe muscular hypotonia (HP:0006829)2.01610401
64IgG deficiency (HP:0004315)2.01603832
65Entropion (HP:0000621)2.01230919
66Hypoplasia of the pons (HP:0012110)1.95392548
67Furrowed tongue (HP:0000221)1.95290057
68Abnormality of the proximal phalanges of the hand (HP:0009834)1.94519138
69Abnormal lung lobation (HP:0002101)1.92650402
70Abnormality of the middle phalanges of the toes (HP:0010183)1.91878928
71Fibular aplasia (HP:0002990)1.91689819
72Aplasia/Hypoplasia of the sacrum (HP:0008517)1.90902171
73Cerebral hypomyelination (HP:0006808)1.90648012
74Abnormal trabecular bone morphology (HP:0100671)1.89138066
75Progressive microcephaly (HP:0000253)1.88834495
76Neoplasm of the adrenal gland (HP:0100631)1.88496367
77Lethargy (HP:0001254)1.87974883
78Hamartoma of the eye (HP:0010568)1.87169927
79Pancytopenia (HP:0001876)1.86076844
80Emotional lability (HP:0000712)1.85815227
81True hermaphroditism (HP:0010459)1.85122728
82Meningioma (HP:0002858)1.85001987
83Aplasia involving bones of the upper limbs (HP:0009823)1.84451924
84Aplasia of the phalanges of the hand (HP:0009802)1.84451924
85Aplasia involving bones of the extremities (HP:0009825)1.84451924
86Abnormality of the pons (HP:0007361)1.83447152
87Ulnar claw (HP:0001178)1.82512113
88Microretrognathia (HP:0000308)1.81961322
89Sparse eyelashes (HP:0000653)1.81831289
90Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.81610183
91Methylmalonic acidemia (HP:0002912)1.80426610
92Flat capital femoral epiphysis (HP:0003370)1.80366646
93Anophthalmia (HP:0000528)1.79553672
94X-linked dominant inheritance (HP:0001423)1.79176639
95Neoplasm of the adrenal cortex (HP:0100641)1.78486917
96Poor head control (HP:0002421)1.78252884
97Congenital ichthyosiform erythroderma (HP:0007431)1.78199045
98Decreased activity of mitochondrial respiratory chain (HP:0008972)1.78161157
99Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.78161157
100Abnormality of renal resorption (HP:0011038)1.77497006

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK26.82932494
2TIE14.85929746
3NME23.74355215
4TAF12.96550031
5NUAK12.96256635
6BUB12.92734416
7VRK12.87304828
8TESK12.32916337
9TESK22.24706592
10MST42.15487481
11LIMK12.09110704
12STK161.89058202
13BCKDK1.83881018
14EPHA21.82498548
15PHKG11.81696401
16PHKG21.81696401
17PBK1.76003495
18CSNK1G31.62591329
19SMG11.58240238
20CSNK1A1L1.56293086
21KDR1.55897879
22ZAK1.52467734
23TSSK61.47533079
24TRIM281.47081977
25CSNK1G11.44483230
26DAPK11.42539855
27EPHB21.42494068
28GRK11.38363723
29PDK21.36075047
30LMTK21.35805834
31PLK31.34167287
32SRPK11.33579179
33DYRK21.31387511
34ADRBK21.29664126
35TNIK1.27455591
36CSNK1G21.23956037
37NEK11.18579126
38GRK51.04107630
39PIM21.00371393
40NEK90.98594996
41MAP2K70.87075772
42BMPR1B0.85524447
43MUSK0.84765038
44ABL20.84296633
45GRK70.83511315
46ARAF0.81112649
47TLK10.75616194
48AURKA0.75124976
49PINK10.71733284
50NME10.70144763
51BLK0.67673413
52PTK2B0.67552686
53ILK0.64894756
54CDK80.64293028
55EIF2AK20.64165565
56PRKCI0.62382442
57TAOK20.61913900
58CCNB10.61773830
59EIF2AK30.60381459
60DAPK30.60322072
61RPS6KA50.59900304
62PAK40.59843239
63EIF2AK10.58116191
64MAP3K120.57257535
65DAPK20.54718272
66MAPKAPK50.51300903
67HIPK20.50645621
68INSRR0.48222262
69ADRBK10.46882503
70CDC70.46209021
71MAPKAPK30.45675979
72FGFR10.45530528
73MAP2K60.45269867
74IKBKB0.45196750
75OXSR10.41106619
76STK390.40982433
77MAP3K110.40624081
78PLK10.40386743
79CDK190.39753639
80IRAK30.39604035
81TEC0.36372515
82CDK70.34638243
83CSNK1A10.34519285
84CHEK20.30840841
85CSNK2A20.30391423
86CSNK2A10.30005219
87BCR0.26934980
88CAMK2G0.25839099
89CAMKK20.24138670
90ATR0.23785942
91STK40.23288550
92MARK10.21856851
93MET0.21331701
94AURKB0.20353194
95PRKCG0.19768625
96IKBKE0.18061626
97CAMK40.17724777
98PLK40.17303703
99MAP3K80.16150278
100GSK3A0.16020517

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.15625572
2Oxidative phosphorylation_Homo sapiens_hsa001904.01207282
3Ribosome_Homo sapiens_hsa030103.77783004
4Parkinsons disease_Homo sapiens_hsa050123.27414528
5Sulfur relay system_Homo sapiens_hsa041223.10765388
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.98476209
7RNA polymerase_Homo sapiens_hsa030202.80857405
8Huntingtons disease_Homo sapiens_hsa050162.53978713
9Alzheimers disease_Homo sapiens_hsa050102.39106738
10Protein export_Homo sapiens_hsa030602.08727088
11Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.91018563
12Folate biosynthesis_Homo sapiens_hsa007901.88680871
13Homologous recombination_Homo sapiens_hsa034401.82169971
14Nucleotide excision repair_Homo sapiens_hsa034201.78363988
15Pyrimidine metabolism_Homo sapiens_hsa002401.77823353
16DNA replication_Homo sapiens_hsa030301.76947501
17Cyanoamino acid metabolism_Homo sapiens_hsa004601.72052428
18Fatty acid elongation_Homo sapiens_hsa000621.71810851
19Cardiac muscle contraction_Homo sapiens_hsa042601.61651134
20Basal transcription factors_Homo sapiens_hsa030221.57021894
21Sulfur metabolism_Homo sapiens_hsa009201.56928522
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.55808939
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.47982332
24Base excision repair_Homo sapiens_hsa034101.47685190
25Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.42688218
26RNA degradation_Homo sapiens_hsa030181.41279006
27Mismatch repair_Homo sapiens_hsa034301.38833484
282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.34077182
29Purine metabolism_Homo sapiens_hsa002301.31160149
30Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.28666913
31RNA transport_Homo sapiens_hsa030131.26708086
32One carbon pool by folate_Homo sapiens_hsa006701.26472737
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.19951500
34Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.11633019
35Pyruvate metabolism_Homo sapiens_hsa006201.04881964
36Peroxisome_Homo sapiens_hsa041461.04752369
37Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.02130584
38Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.01625197
39Spliceosome_Homo sapiens_hsa030401.00563388
40Vitamin B6 metabolism_Homo sapiens_hsa007500.96593143
41Biosynthesis of amino acids_Homo sapiens_hsa012300.94523555
42Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.91178515
43Glutathione metabolism_Homo sapiens_hsa004800.90910076
44Selenocompound metabolism_Homo sapiens_hsa004500.89543092
45Carbon metabolism_Homo sapiens_hsa012000.88517654
46Primary bile acid biosynthesis_Homo sapiens_hsa001200.85395763
47Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.84640701
48Fructose and mannose metabolism_Homo sapiens_hsa000510.81061155
49Metabolic pathways_Homo sapiens_hsa011000.78405222
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.77815024
51Cysteine and methionine metabolism_Homo sapiens_hsa002700.76638902
52Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.75854373
53Caffeine metabolism_Homo sapiens_hsa002320.75744083
54Tryptophan metabolism_Homo sapiens_hsa003800.75592494
55Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.75086897
56Steroid biosynthesis_Homo sapiens_hsa001000.73640534
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.73435703
58Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70819915
59Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.70220566
60Primary immunodeficiency_Homo sapiens_hsa053400.68772657
61Nitrogen metabolism_Homo sapiens_hsa009100.66401226
62Pentose phosphate pathway_Homo sapiens_hsa000300.66218957
63Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.64357420
64N-Glycan biosynthesis_Homo sapiens_hsa005100.62969978
65Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.62673714
66Salivary secretion_Homo sapiens_hsa049700.62445952
67Collecting duct acid secretion_Homo sapiens_hsa049660.61783375
68Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.59958292
69Non-homologous end-joining_Homo sapiens_hsa034500.58718337
70Fanconi anemia pathway_Homo sapiens_hsa034600.58590846
71Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.54146626
72Nicotine addiction_Homo sapiens_hsa050330.50124518
73Galactose metabolism_Homo sapiens_hsa000520.49872359
74Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.49005639
75SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48580727
76Propanoate metabolism_Homo sapiens_hsa006400.46168331
77Steroid hormone biosynthesis_Homo sapiens_hsa001400.45426146
78Vibrio cholerae infection_Homo sapiens_hsa051100.44988194
79Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.42170813
80Intestinal immune network for IgA production_Homo sapiens_hsa046720.39112856
81Mineral absorption_Homo sapiens_hsa049780.36709421
82Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.36037524
83Retinol metabolism_Homo sapiens_hsa008300.35709554
84Arginine and proline metabolism_Homo sapiens_hsa003300.35243637
85Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.32052724
86Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.30657617
87Chemical carcinogenesis_Homo sapiens_hsa052040.30584701
88Arginine biosynthesis_Homo sapiens_hsa002200.29345039
89Morphine addiction_Homo sapiens_hsa050320.29124280
90Basal cell carcinoma_Homo sapiens_hsa052170.28143416
91Regulation of autophagy_Homo sapiens_hsa041400.26615574
92Pentose and glucuronate interconversions_Homo sapiens_hsa000400.25544152
93Insulin secretion_Homo sapiens_hsa049110.24752439
94Epstein-Barr virus infection_Homo sapiens_hsa051690.20534252
95Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.18087369
96Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.16791885
97Systemic lupus erythematosus_Homo sapiens_hsa053220.15857621
98Maturity onset diabetes of the young_Homo sapiens_hsa049500.15801163
99Rheumatoid arthritis_Homo sapiens_hsa053230.15465275
100Fatty acid degradation_Homo sapiens_hsa000710.14716775

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