GAPDHP31

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chaperone-mediated protein transport (GO:0072321)6.05272107
2DNA deamination (GO:0045006)5.65349314
3regulation of chronic inflammatory response (GO:0002676)5.57252321
4ATP synthesis coupled proton transport (GO:0015986)5.48147101
5energy coupled proton transport, down electrochemical gradient (GO:0015985)5.48147101
6mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.98482136
7protein neddylation (GO:0045116)4.89043661
8maturation of SSU-rRNA (GO:0030490)4.81119403
9proteasome assembly (GO:0043248)4.72815817
10establishment of protein localization to mitochondrial membrane (GO:0090151)4.58446085
11rRNA modification (GO:0000154)4.51834151
12positive regulation of prostaglandin secretion (GO:0032308)4.30513388
13regulation of response to tumor cell (GO:0002834)4.27166545
14positive regulation of response to tumor cell (GO:0002836)4.27166545
15positive regulation of immune response to tumor cell (GO:0002839)4.27166545
16regulation of immune response to tumor cell (GO:0002837)4.27166545
17regulation of immunoglobulin secretion (GO:0051023)4.22959848
18regulation of isotype switching to IgG isotypes (GO:0048302)4.01371220
19ribosomal large subunit biogenesis (GO:0042273)4.00643762
20pseudouridine synthesis (GO:0001522)4.00421966
21regulation of cellular amino acid metabolic process (GO:0006521)4.00317259
22negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.84839012
23protein complex biogenesis (GO:0070271)3.84418283
24rRNA methylation (GO:0031167)3.84362106
25mitochondrial respiratory chain complex I assembly (GO:0032981)3.80500234
26NADH dehydrogenase complex assembly (GO:0010257)3.80500234
27mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.80500234
28protein deneddylation (GO:0000338)3.78919877
29mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.78565377
30water-soluble vitamin biosynthetic process (GO:0042364)3.72124934
31DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.66951719
32respiratory electron transport chain (GO:0022904)3.64958302
33mitochondrial respiratory chain complex assembly (GO:0033108)3.64607325
34electron transport chain (GO:0022900)3.62926384
35signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.61899112
36signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.61899112
37signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.61899112
38intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.55697868
39signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.55697868
40ribosomal small subunit biogenesis (GO:0042274)3.52924800
41regulation of prostaglandin secretion (GO:0032306)3.52325386
42regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.50373496
43regulation of mitotic spindle checkpoint (GO:1903504)3.50373496
44exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.48880663
45signal transduction involved in DNA integrity checkpoint (GO:0072401)3.45503811
46signal transduction involved in DNA damage checkpoint (GO:0072422)3.45503811
47positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.45197965
48ribosomal small subunit assembly (GO:0000028)3.41234559
49signal transduction involved in cell cycle checkpoint (GO:0072395)3.39579730
50maturation of 5.8S rRNA (GO:0000460)3.38691448
51aldehyde catabolic process (GO:0046185)3.38265724
52negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.38027574
53negative regulation of ligase activity (GO:0051352)3.38027574
54somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.37464660
55somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.37464660
56isotype switching (GO:0045190)3.37464660
57nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.37075000
58protein-cofactor linkage (GO:0018065)3.35916352
59GTP biosynthetic process (GO:0006183)3.32528075
60regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.30388121
61activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO3.28779255
62viral transcription (GO:0019083)3.25496849
63protein targeting to mitochondrion (GO:0006626)3.25447145
64purine nucleoside triphosphate biosynthetic process (GO:0009145)3.25271218
65purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.22029158
66translation (GO:0006412)3.21691118
67ATP biosynthetic process (GO:0006754)3.18713711
68folic acid-containing compound biosynthetic process (GO:0009396)3.17786112
69respiratory chain complex IV assembly (GO:0008535)3.16846962
70rRNA processing (GO:0006364)3.13321408
71anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.10620493
72establishment of protein localization to mitochondrion (GO:0072655)3.09798230
73translational termination (GO:0006415)3.08772475
74rRNA metabolic process (GO:0016072)3.08495673
75cellular component biogenesis (GO:0044085)3.07308081
76SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.03398191
77positive regulation of fatty acid transport (GO:2000193)3.03323027
78antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.03054051
79ribonucleoprotein complex biogenesis (GO:0022613)3.01643402
80protein localization to mitochondrion (GO:0070585)3.00053211
81CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.99296315
82cotranslational protein targeting to membrane (GO:0006613)2.98950495
83tolerance induction (GO:0002507)2.98922103
84cullin deneddylation (GO:0010388)2.98557804
85protein targeting to ER (GO:0045047)2.97988218
86negative regulation of nitric oxide biosynthetic process (GO:0045019)2.97207124
87behavioral response to nicotine (GO:0035095)2.90340194
88translational elongation (GO:0006414)2.88298118
89regulation of female receptivity (GO:0045924)2.88058574
90positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.87703567
91positive regulation of icosanoid secretion (GO:0032305)2.86762748
92regulation of cellular amine metabolic process (GO:0033238)2.86313412
93hydrogen ion transmembrane transport (GO:1902600)2.85596317
94ribonucleoside triphosphate biosynthetic process (GO:0009201)2.84457838
95cytochrome complex assembly (GO:0017004)2.81234949
96positive regulation of cell cycle arrest (GO:0071158)2.79528136
97protein localization to endoplasmic reticulum (GO:0070972)2.79285689
98antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.77669978
99establishment of protein localization to endoplasmic reticulum (GO:0072599)2.76406574
100metallo-sulfur cluster assembly (GO:0031163)2.75011983

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human6.11055456
2GABP_17652178_ChIP-ChIP_JURKAT_Human5.24874836
3EST1_17652178_ChIP-ChIP_JURKAT_Human4.31696901
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.77420077
5ETS1_20019798_ChIP-Seq_JURKAT_Human3.42698879
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.41060077
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.33408377
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.19903975
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.92753120
10YY1_21170310_ChIP-Seq_MESCs_Mouse2.87552517
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.79638743
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.79359998
13VDR_23849224_ChIP-Seq_CD4+_Human2.71992545
14ELK1_19687146_ChIP-ChIP_HELA_Human2.42258441
15NOTCH1_21737748_ChIP-Seq_TLL_Human2.36420315
16E2F4_17652178_ChIP-ChIP_JURKAT_Human2.31466257
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.31355073
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.27253668
19MYC_18358816_ChIP-ChIP_MESCs_Mouse2.23384263
20HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.19364078
21FOXP3_21729870_ChIP-Seq_TREG_Human2.08374625
22HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.06613974
23ELF1_17652178_ChIP-ChIP_JURKAT_Human1.96027543
24IGF1R_20145208_ChIP-Seq_DFB_Human1.95058120
25TTF2_22483619_ChIP-Seq_HELA_Human1.90704954
26ZNF274_21170338_ChIP-Seq_K562_Hela1.89162168
27SRF_21415370_ChIP-Seq_HL-1_Mouse1.85268027
28EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.85230227
29CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.79427969
30MYC_18940864_ChIP-ChIP_HL60_Human1.78654587
31MYC_19030024_ChIP-ChIP_MESCs_Mouse1.76076015
32PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.73601467
33DCP1A_22483619_ChIP-Seq_HELA_Human1.73516767
34THAP11_20581084_ChIP-Seq_MESCs_Mouse1.73096190
35XRN2_22483619_ChIP-Seq_HELA_Human1.72632194
36FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.70796913
37MYC_19079543_ChIP-ChIP_MESCs_Mouse1.67680569
38CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.58505294
39TP53_22573176_ChIP-Seq_HFKS_Human1.58149721
40EWS_26573619_Chip-Seq_HEK293_Human1.55172437
41GABP_19822575_ChIP-Seq_HepG2_Human1.54527213
42HOXB4_20404135_ChIP-ChIP_EML_Mouse1.49002431
43E2F1_18555785_ChIP-Seq_MESCs_Mouse1.46332072
44PADI4_21655091_ChIP-ChIP_MCF-7_Human1.44660695
45PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43074579
46ELK1_22589737_ChIP-Seq_MCF10A_Human1.37714834
47POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.37442805
48FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.36154601
49EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.33234505
50FLI1_27457419_Chip-Seq_LIVER_Mouse1.32415238
51SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.31187219
52VDR_22108803_ChIP-Seq_LS180_Human1.31181686
53TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.26380920
54LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24750505
55ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.22567469
56FOXA1_25329375_ChIP-Seq_VCAP_Human1.19645704
57FOXA1_27270436_Chip-Seq_PROSTATE_Human1.19645704
58IRF1_19129219_ChIP-ChIP_H3396_Human1.19069943
59KDM5A_27292631_Chip-Seq_BREAST_Human1.16597152
60PCGF2_27294783_Chip-Seq_NPCs_Mouse1.12538338
61PCGF2_27294783_Chip-Seq_ESCs_Mouse1.09902257
62MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.08377731
63PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.06390201
64CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.04571170
65YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04519710
66AUTS2_25519132_ChIP-Seq_293T-REX_Human1.02874587
67BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.02321906
68CTCF_18555785_ChIP-Seq_MESCs_Mouse1.02302405
69CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.01384521
70GATA3_21878914_ChIP-Seq_MCF-7_Human1.01306566
71NCOR_22424771_ChIP-Seq_293T_Human1.00773868
72FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.00285648
73ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.99513926
74NELFA_20434984_ChIP-Seq_ESCs_Mouse0.98366666
75MYC_19829295_ChIP-Seq_ESCs_Human0.96805428
76MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.95564170
77LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.92481399
78TAF2_19829295_ChIP-Seq_ESCs_Human0.91885326
79EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.91024410
80GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.90046851
81SALL4_22934838_ChIP-ChIP_CD34+_Human0.87998011
82FOXH1_21741376_ChIP-Seq_EPCs_Human0.87315549
83SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.85956171
84FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85851193
85PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.83636237
86HOXB7_26014856_ChIP-Seq_BT474_Human0.82908805
87AR_20517297_ChIP-Seq_VCAP_Human0.82768615
88PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.81627888
89IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.81115168
90STAT4_19710469_ChIP-ChIP_TH1__Mouse0.80224071
91P53_21459846_ChIP-Seq_SAOS-2_Human0.79484980
92NFE2_27457419_Chip-Seq_LIVER_Mouse0.79020619
93FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.78482954
94ERG_20517297_ChIP-Seq_VCAP_Human0.78174954
95TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.77504382
96GATA3_26560356_Chip-Seq_TH2_Human0.77454424
97IRF8_22096565_ChIP-ChIP_GC-B_Human0.76378069
98TDRD3_21172665_ChIP-Seq_MCF-7_Human0.75946634
99EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.75641463
100STAT1_20625510_ChIP-Seq_HELA_Human0.74988680

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001348_abnormal_lacrimal_gland4.30878175
2MP0005646_abnormal_pituitary_gland3.64540716
3MP0004147_increased_porphyrin_level3.42421954
4MP0002163_abnormal_gland_morphology3.38142949
5MP0002102_abnormal_ear_morphology3.03448176
6MP0000685_abnormal_immune_system2.93784541
7MP0001873_stomach_inflammation2.80915619
8MP0008875_abnormal_xenobiotic_pharmacok2.72450009
9MP0003646_muscle_fatigue2.48372663
10MP0008872_abnormal_physiological_respon2.43474746
11MP0006036_abnormal_mitochondrial_physio2.40936827
12MP0009333_abnormal_splenocyte_physiolog2.16638910
13MP0001835_abnormal_antigen_presentation1.96638332
14MP0005379_endocrine/exocrine_gland_phen1.93752978
15MP0001529_abnormal_vocalization1.88194135
16MP0005671_abnormal_response_to1.87916129
17MP0003011_delayed_dark_adaptation1.82780265
18MP0001968_abnormal_touch/_nociception1.80112366
19MP0003315_abnormal_perineum_morphology1.79542976
20MP0004885_abnormal_endolymph1.70050682
21MP0008877_abnormal_DNA_methylation1.68335771
22MP0002736_abnormal_nociception_after1.67195845
23MP0001790_abnormal_immune_system1.61631751
24MP0005387_immune_system_phenotype1.61631751
25MP0002006_tumorigenesis1.58834063
26MP0001984_abnormal_olfaction1.57880685
27MP0008789_abnormal_olfactory_epithelium1.56607307
28MP0003693_abnormal_embryo_hatching1.56244728
29MP0003718_maternal_effect1.53829742
30MP0005084_abnormal_gallbladder_morpholo1.50177150
31MP0005645_abnormal_hypothalamus_physiol1.49273501
32MP0003045_fibrosis1.49270243
33MP0004145_abnormal_muscle_electrophysio1.48907825
34MP0005187_abnormal_penis_morphology1.48287139
35MP0002138_abnormal_hepatobiliary_system1.44526144
36MP0002277_abnormal_respiratory_mucosa1.43630992
37MP0001346_abnormal_lacrimal_gland1.41290528
38MP0009764_decreased_sensitivity_to1.39899013
39MP0006276_abnormal_autonomic_nervous1.38727182
40MP0001440_abnormal_grooming_behavior1.35912425
41MP0002160_abnormal_reproductive_system1.35213282
42MP0006082_CNS_inflammation1.32581296
43MP0004142_abnormal_muscle_tone1.30607452
44MP0005167_abnormal_blood-brain_barrier1.29545356
45MP0003866_abnormal_defecation1.28152459
46MP0001986_abnormal_taste_sensitivity1.26858189
47MP0002166_altered_tumor_susceptibility1.25247652
48MP0003786_premature_aging1.24965006
49MP0001800_abnormal_humoral_immune1.18759805
50MP0003806_abnormal_nucleotide_metabolis1.18364126
51MP0004043_abnormal_pH_regulation1.17149845
52MP0002272_abnormal_nervous_system1.12525217
53MP0002733_abnormal_thermal_nociception1.12079661
54MP0002148_abnormal_hypersensitivity_rea1.11586342
55MP0002876_abnormal_thyroid_physiology1.11230830
56MP0005499_abnormal_olfactory_system1.10953596
57MP0005394_taste/olfaction_phenotype1.10953596
58MP0003186_abnormal_redox_activity1.09778325
59MP0008058_abnormal_DNA_repair1.08856080
60MP0003763_abnormal_thymus_physiology1.06221283
61MP0006035_abnormal_mitochondrial_morpho1.04642130
62MP0006292_abnormal_olfactory_placode1.04004414
63MP0001663_abnormal_digestive_system0.98334104
64MP0005389_reproductive_system_phenotype0.97952046
65MP0005551_abnormal_eye_electrophysiolog0.97067385
66MP0005000_abnormal_immune_tolerance0.96874284
67MP0005377_hearing/vestibular/ear_phenot0.96618829
68MP0003878_abnormal_ear_physiology0.96618829
69MP0003567_abnormal_fetal_cardiomyocyte0.95906162
70MP0001881_abnormal_mammary_gland0.94915742
71MP0000613_abnormal_salivary_gland0.92755553
72MP0008007_abnormal_cellular_replicative0.92158933
73MP0002723_abnormal_immune_serum0.87063979
74MP0004742_abnormal_vestibular_system0.86909417
75MP0009745_abnormal_behavioral_response0.86304605
76MP0010094_abnormal_chromosome_stability0.85556910
77MP0002735_abnormal_chemical_nociception0.84821188
78MP0006072_abnormal_retinal_apoptosis0.82785206
79MP0001293_anophthalmia0.81996547
80MP0003959_abnormal_lean_body0.79596793
81MP0003436_decreased_susceptibility_to0.79471832
82MP0005332_abnormal_amino_acid0.79335427
83MP0002405_respiratory_system_inflammati0.78512961
84MP0005310_abnormal_salivary_gland0.75978173
85MP0008775_abnormal_heart_ventricle0.75491309
86MP0001905_abnormal_dopamine_level0.75322127
87MP0001970_abnormal_pain_threshold0.74294756
88MP0008932_abnormal_embryonic_tissue0.74278799
89MP0000689_abnormal_spleen_morphology0.73176384
90MP0005448_abnormal_energy_balance0.72202782
91MP0009785_altered_susceptibility_to0.71532816
92MP0000631_abnormal_neuroendocrine_gland0.71284978
93MP0005636_abnormal_mineral_homeostasis0.70110126
94MP0000703_abnormal_thymus_morphology0.69747114
95MP0005083_abnormal_biliary_tract0.69629791
96MP0000230_abnormal_systemic_arterial0.67384539
97MP0003787_abnormal_imprinting0.67181887
98MP0001919_abnormal_reproductive_system0.64705391
99MP0004957_abnormal_blastocyst_morpholog0.63892318
100MP0003936_abnormal_reproductive_system0.63141169

Predicted human phenotypes

RankGene SetZ-score
1Increased hepatocellular lipid droplets (HP:0006565)4.51418025
2Acute necrotizing encephalopathy (HP:0006965)4.50480991
3Increased IgM level (HP:0003496)4.13612424
4Lipid accumulation in hepatocytes (HP:0006561)4.07569458
5Abnormal mitochondria in muscle tissue (HP:0008316)4.07027281
6Mitochondrial inheritance (HP:0001427)3.95571044
7Increased CSF lactate (HP:0002490)3.91670336
8Acute encephalopathy (HP:0006846)3.90780233
9Stomatitis (HP:0010280)3.88962000
10Increased intramyocellular lipid droplets (HP:0012240)3.77807986
11Renal Fanconi syndrome (HP:0001994)3.75589109
12Progressive macrocephaly (HP:0004481)3.65235571
13Exertional dyspnea (HP:0002875)3.31530376
14Congenital, generalized hypertrichosis (HP:0004540)3.20596126
15Increased serum lactate (HP:0002151)3.15975673
16Increased muscle lipid content (HP:0009058)3.13691368
17Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.12125540
183-Methylglutaconic aciduria (HP:0003535)3.03754703
19Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.87972137
20IgG deficiency (HP:0004315)2.86046895
21Absent/shortened dynein arms (HP:0200106)2.83698896
22Dynein arm defect of respiratory motile cilia (HP:0012255)2.83698896
23Septo-optic dysplasia (HP:0100842)2.81364162
24Cerebral edema (HP:0002181)2.80021177
25Molar tooth sign on MRI (HP:0002419)2.79414610
26Abnormality of midbrain morphology (HP:0002418)2.79414610
27Nephronophthisis (HP:0000090)2.79410142
28Abnormality of the labia minora (HP:0012880)2.78785321
29Colon cancer (HP:0003003)2.76340719
30Optic disc pallor (HP:0000543)2.74881067
31Progressive microcephaly (HP:0000253)2.68008484
32Abnormality of the renal medulla (HP:0100957)2.54244082
33Respiratory difficulties (HP:0002880)2.52339310
34Absent rod-and cone-mediated responses on ERG (HP:0007688)2.46204861
35Abnormality of T cell physiology (HP:0011840)2.45922003
36Abnormality of cells of the erythroid lineage (HP:0012130)2.45534669
37Lactic acidosis (HP:0003128)2.43577038
38Hepatocellular necrosis (HP:0001404)2.42919582
39Abnormal number of erythroid precursors (HP:0012131)2.42082330
40Aplasia/Hypoplasia of the spleen (HP:0010451)2.39331585
41Hypochromic anemia (HP:0001931)2.36909341
42Exercise intolerance (HP:0003546)2.35872051
43Asplenia (HP:0001746)2.35177466
44Optic nerve coloboma (HP:0000588)2.35093193
45Hypochromic microcytic anemia (HP:0004840)2.34370537
46Congenital stationary night blindness (HP:0007642)2.34221761
47Hepatic necrosis (HP:0002605)2.31652509
48Hypoplasia of the pons (HP:0012110)2.30127250
49Abnormality of the pons (HP:0007361)2.27870957
50Abnormality of the renal cortex (HP:0011035)2.26878801
51Abnormality of renal resorption (HP:0011038)2.26341686
52Macrocytic anemia (HP:0001972)2.25912563
53Abnormal rod and cone electroretinograms (HP:0008323)2.25536259
54Neuroendocrine neoplasm (HP:0100634)2.24731502
55Polydipsia (HP:0001959)2.22851782
56Abnormal drinking behavior (HP:0030082)2.22851782
57Pancreatic cysts (HP:0001737)2.21756671
58Decreased activity of mitochondrial respiratory chain (HP:0008972)2.20198152
59Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.20198152
60Cerebral hypomyelination (HP:0006808)2.17651152
61Autoimmune hemolytic anemia (HP:0001890)2.17261240
62Tubulointerstitial nephritis (HP:0001970)2.16691326
63Elevated erythrocyte sedimentation rate (HP:0003565)2.15420732
64Reticulocytopenia (HP:0001896)2.11987546
65Abnormal ciliary motility (HP:0012262)2.08584558
66Lethargy (HP:0001254)2.07053037
67Methylmalonic acidemia (HP:0002912)2.06453370
68Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.04278357
69Abnormality of alanine metabolism (HP:0010916)2.04278357
70Hyperalaninemia (HP:0003348)2.04278357
71Respiratory failure (HP:0002878)2.02325675
72Bile duct proliferation (HP:0001408)2.01912048
73Abnormal biliary tract physiology (HP:0012439)2.01912048
74Abnormal delayed hypersensitivity skin test (HP:0002963)2.00626370
75Pendular nystagmus (HP:0012043)1.98380430
76Abnormal respiratory epithelium morphology (HP:0012253)1.98021943
77Abnormal respiratory motile cilium morphology (HP:0005938)1.98021943
78Renal cortical cysts (HP:0000803)1.97620938
79Neutropenia (HP:0001875)1.94395867
80Glycosuria (HP:0003076)1.93705304
81Abnormality of urine glucose concentration (HP:0011016)1.93705304
82Cleft eyelid (HP:0000625)1.91872759
83Abnormality of T cells (HP:0002843)1.91835998
84Optic nerve hypoplasia (HP:0000609)1.89640228
85Leukodystrophy (HP:0002415)1.88835341
86Absent septum pellucidum (HP:0001331)1.88371251
87Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.87135145
88True hermaphroditism (HP:0010459)1.86772541
89CNS hypomyelination (HP:0003429)1.85762628
90Neoplasm of head and neck (HP:0012288)1.84977740
91Esophageal neoplasm (HP:0100751)1.84977740
92Type 2 muscle fiber atrophy (HP:0003554)1.83782130
93Tinnitus (HP:0000360)1.81413989
94Stomach cancer (HP:0012126)1.81034633
95Pancreatic fibrosis (HP:0100732)1.80905025
96Rhinitis (HP:0012384)1.78719207
97Methylmalonic aciduria (HP:0012120)1.78241572
98Pallor (HP:0000980)1.77749177
99Posterior subcapsular cataract (HP:0007787)1.77244229
100Abnormality of the vocal cords (HP:0008777)1.73548984

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TSSK63.85894443
2VRK23.54918137
3NUAK13.06219249
4PBK2.95251478
5TXK2.86979318
6TLK12.62737098
7BUB12.60301677
8EIF2AK32.56644912
9WNK42.51634712
10ZAK2.49504442
11TIE12.42012629
12GRK12.41910821
13NEK12.36605542
14EIF2AK12.24777839
15STK162.13058269
16ADRBK22.12040357
17NME22.00041121
18PLK31.89257520
19EIF2AK21.81430932
20VRK11.68070763
21BMPR1B1.64006862
22CDK81.57282375
23NME11.56083160
24PDK21.44061802
25IKBKE1.41234247
26IKBKB1.39439508
27TGFBR21.35424334
28MST41.31948716
29SRPK11.31119809
30BCR1.27631804
31MAP2K21.25280812
32STK391.25100420
33WNK31.24355944
34TNIK1.23437360
35OXSR11.21588669
36PIK3CA1.16626044
37DYRK21.15417130
38FES1.14758199
39KIT1.11518741
40BCKDK1.11084888
41PLK21.09577380
42FRK1.05541958
43CDC71.04032221
44CSNK1G21.03134840
45TAOK30.95074175
46MAP3K140.91405099
47BRD40.84887883
48DAPK10.83803267
49STK40.82319268
50CSNK1G30.77193144
51GRK70.76365964
52MAP2K60.72713001
53TBK10.71106343
54PAK30.69142108
55ALK0.63978678
56CDK190.63937766
57ADRBK10.63071318
58DAPK20.59376588
59TEC0.57494697
60PRKCG0.56787448
61CSNK1G10.55395298
62TAF10.53717437
63PLK10.53176461
64CAMKK20.52995333
65CSNK1A1L0.51967819
66PIM20.51957435
67CSNK2A20.51431755
68PHKG20.51352992
69PHKG10.51352992
70GRK50.50133581
71ABL20.49694523
72PIK3CG0.48731805
73MARK30.48436281
74ATR0.48375175
75PAK40.47909446
76INSRR0.47735703
77MAP4K20.43515766
78WNK10.42794164
79TGFBR10.41742334
80STK38L0.41709398
81MAPK130.41584644
82TRIM280.40411432
83CAMK1D0.40389620
84PRKCQ0.40127180
85RPS6KA50.39878737
86PRKCI0.39812806
87BRSK20.39752149
88LCK0.38963289
89CSNK2A10.38822617
90AURKB0.37602990
91CAMK2A0.37071497
92RPS6KA10.35822355
93SYK0.35254258
94WEE10.34740312
95ERBB20.34692694
96PAK60.34156125
97STK240.34027373
98CHEK20.33836375
99CSNK1E0.33621559
100MINK10.33567730

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.01198618
2Ribosome_Homo sapiens_hsa030103.89267386
3Oxidative phosphorylation_Homo sapiens_hsa001903.64275808
4Parkinsons disease_Homo sapiens_hsa050123.22412862
5Protein export_Homo sapiens_hsa030602.99942997
6One carbon pool by folate_Homo sapiens_hsa006702.86575708
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.58446554
8Asthma_Homo sapiens_hsa053102.44436987
9RNA polymerase_Homo sapiens_hsa030202.37109211
10Vitamin B6 metabolism_Homo sapiens_hsa007502.23705414
11Alzheimers disease_Homo sapiens_hsa050102.15464335
12Huntingtons disease_Homo sapiens_hsa050162.15052402
13Allograft rejection_Homo sapiens_hsa053302.10562365
14Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.96877341
15Autoimmune thyroid disease_Homo sapiens_hsa053201.95964239
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.95174460
17Nitrogen metabolism_Homo sapiens_hsa009101.85587603
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.80374029
19Intestinal immune network for IgA production_Homo sapiens_hsa046721.67287815
20Sulfur relay system_Homo sapiens_hsa041221.62850580
21Primary immunodeficiency_Homo sapiens_hsa053401.61803356
22Cardiac muscle contraction_Homo sapiens_hsa042601.58929094
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.58499096
24RNA degradation_Homo sapiens_hsa030181.43060845
25RNA transport_Homo sapiens_hsa030131.36651907
26Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.31984118
27DNA replication_Homo sapiens_hsa030301.28964278
28Spliceosome_Homo sapiens_hsa030401.25849231
29Fatty acid elongation_Homo sapiens_hsa000621.22966916
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.22371539
31Homologous recombination_Homo sapiens_hsa034401.19582532
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.18388903
33Pyrimidine metabolism_Homo sapiens_hsa002401.18186305
34Basal transcription factors_Homo sapiens_hsa030221.16387839
35Linoleic acid metabolism_Homo sapiens_hsa005911.13282363
36Mismatch repair_Homo sapiens_hsa034301.09221566
37Caffeine metabolism_Homo sapiens_hsa002321.07104590
38Phototransduction_Homo sapiens_hsa047441.05096339
39Propanoate metabolism_Homo sapiens_hsa006401.04137302
40Fanconi anemia pathway_Homo sapiens_hsa034600.98531754
41Base excision repair_Homo sapiens_hsa034100.97851167
42Nucleotide excision repair_Homo sapiens_hsa034200.97675420
43Peroxisome_Homo sapiens_hsa041460.95917676
44Tryptophan metabolism_Homo sapiens_hsa003800.93842292
45alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.89416508
46Pyruvate metabolism_Homo sapiens_hsa006200.87670660
47Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.81661906
48Type I diabetes mellitus_Homo sapiens_hsa049400.80285146
49Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.77483984
50Purine metabolism_Homo sapiens_hsa002300.75910729
51Nicotine addiction_Homo sapiens_hsa050330.74717119
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.72699682
53Folate biosynthesis_Homo sapiens_hsa007900.72608040
54Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.71519495
55Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.70903869
56Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.70539788
57Metabolic pathways_Homo sapiens_hsa011000.67621168
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.67408211
59beta-Alanine metabolism_Homo sapiens_hsa004100.67214162
60NF-kappa B signaling pathway_Homo sapiens_hsa040640.64867383
61Collecting duct acid secretion_Homo sapiens_hsa049660.64721844
62Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.62694233
63Retinol metabolism_Homo sapiens_hsa008300.62600118
64Selenocompound metabolism_Homo sapiens_hsa004500.61755942
65Sulfur metabolism_Homo sapiens_hsa009200.58546364
66Rheumatoid arthritis_Homo sapiens_hsa053230.57038351
67Vitamin digestion and absorption_Homo sapiens_hsa049770.55003812
68Steroid hormone biosynthesis_Homo sapiens_hsa001400.54775661
69Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.54172288
70Arginine biosynthesis_Homo sapiens_hsa002200.54055657
71Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.54039043
72Chemical carcinogenesis_Homo sapiens_hsa052040.51504667
73Hematopoietic cell lineage_Homo sapiens_hsa046400.50449613
74Fat digestion and absorption_Homo sapiens_hsa049750.49465185
75Non-homologous end-joining_Homo sapiens_hsa034500.46602116
76Arachidonic acid metabolism_Homo sapiens_hsa005900.45793001
77Mineral absorption_Homo sapiens_hsa049780.45556087
78Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45371403
79Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.45293620
80Ether lipid metabolism_Homo sapiens_hsa005650.43052730
81Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.42749404
82Legionellosis_Homo sapiens_hsa051340.41716686
83NOD-like receptor signaling pathway_Homo sapiens_hsa046210.41264024
84Butanoate metabolism_Homo sapiens_hsa006500.40539579
85Graft-versus-host disease_Homo sapiens_hsa053320.39372615
86Arginine and proline metabolism_Homo sapiens_hsa003300.37368498
87Carbon metabolism_Homo sapiens_hsa012000.36878751
88Antigen processing and presentation_Homo sapiens_hsa046120.36551712
89Steroid biosynthesis_Homo sapiens_hsa001000.35447081
90Olfactory transduction_Homo sapiens_hsa047400.35310762
912-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.31706024
92Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.31362636
93Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.30482758
94Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.30343974
95Pentose and glucuronate interconversions_Homo sapiens_hsa000400.29685838
96T cell receptor signaling pathway_Homo sapiens_hsa046600.29105335
97Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.28949851
98p53 signaling pathway_Homo sapiens_hsa041150.28017366
99Drug metabolism - other enzymes_Homo sapiens_hsa009830.27064343
100Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.26988060

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