

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | chaperone-mediated protein transport (GO:0072321) | 6.05272107 |
| 2 | DNA deamination (GO:0045006) | 5.65349314 |
| 3 | regulation of chronic inflammatory response (GO:0002676) | 5.57252321 |
| 4 | ATP synthesis coupled proton transport (GO:0015986) | 5.48147101 |
| 5 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 5.48147101 |
| 6 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 4.98482136 |
| 7 | protein neddylation (GO:0045116) | 4.89043661 |
| 8 | maturation of SSU-rRNA (GO:0030490) | 4.81119403 |
| 9 | proteasome assembly (GO:0043248) | 4.72815817 |
| 10 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.58446085 |
| 11 | rRNA modification (GO:0000154) | 4.51834151 |
| 12 | positive regulation of prostaglandin secretion (GO:0032308) | 4.30513388 |
| 13 | regulation of response to tumor cell (GO:0002834) | 4.27166545 |
| 14 | positive regulation of response to tumor cell (GO:0002836) | 4.27166545 |
| 15 | positive regulation of immune response to tumor cell (GO:0002839) | 4.27166545 |
| 16 | regulation of immune response to tumor cell (GO:0002837) | 4.27166545 |
| 17 | regulation of immunoglobulin secretion (GO:0051023) | 4.22959848 |
| 18 | regulation of isotype switching to IgG isotypes (GO:0048302) | 4.01371220 |
| 19 | ribosomal large subunit biogenesis (GO:0042273) | 4.00643762 |
| 20 | pseudouridine synthesis (GO:0001522) | 4.00421966 |
| 21 | regulation of cellular amino acid metabolic process (GO:0006521) | 4.00317259 |
| 22 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.84839012 |
| 23 | protein complex biogenesis (GO:0070271) | 3.84418283 |
| 24 | rRNA methylation (GO:0031167) | 3.84362106 |
| 25 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.80500234 |
| 26 | NADH dehydrogenase complex assembly (GO:0010257) | 3.80500234 |
| 27 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.80500234 |
| 28 | protein deneddylation (GO:0000338) | 3.78919877 |
| 29 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.78565377 |
| 30 | water-soluble vitamin biosynthetic process (GO:0042364) | 3.72124934 |
| 31 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.66951719 |
| 32 | respiratory electron transport chain (GO:0022904) | 3.64958302 |
| 33 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.64607325 |
| 34 | electron transport chain (GO:0022900) | 3.62926384 |
| 35 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.61899112 |
| 36 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.61899112 |
| 37 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.61899112 |
| 38 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.55697868 |
| 39 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.55697868 |
| 40 | ribosomal small subunit biogenesis (GO:0042274) | 3.52924800 |
| 41 | regulation of prostaglandin secretion (GO:0032306) | 3.52325386 |
| 42 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 3.50373496 |
| 43 | regulation of mitotic spindle checkpoint (GO:1903504) | 3.50373496 |
| 44 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.48880663 |
| 45 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.45503811 |
| 46 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.45503811 |
| 47 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.45197965 |
| 48 | ribosomal small subunit assembly (GO:0000028) | 3.41234559 |
| 49 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.39579730 |
| 50 | maturation of 5.8S rRNA (GO:0000460) | 3.38691448 |
| 51 | aldehyde catabolic process (GO:0046185) | 3.38265724 |
| 52 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.38027574 |
| 53 | negative regulation of ligase activity (GO:0051352) | 3.38027574 |
| 54 | somatic recombination of immunoglobulin genes involved in immune response (GO:0002204) | 3.37464660 |
| 55 | somatic diversification of immunoglobulins involved in immune response (GO:0002208) | 3.37464660 |
| 56 | isotype switching (GO:0045190) | 3.37464660 |
| 57 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.37075000 |
| 58 | protein-cofactor linkage (GO:0018065) | 3.35916352 |
| 59 | GTP biosynthetic process (GO:0006183) | 3.32528075 |
| 60 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.30388121 |
| 61 | activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO | 3.28779255 |
| 62 | viral transcription (GO:0019083) | 3.25496849 |
| 63 | protein targeting to mitochondrion (GO:0006626) | 3.25447145 |
| 64 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 3.25271218 |
| 65 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 3.22029158 |
| 66 | translation (GO:0006412) | 3.21691118 |
| 67 | ATP biosynthetic process (GO:0006754) | 3.18713711 |
| 68 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.17786112 |
| 69 | respiratory chain complex IV assembly (GO:0008535) | 3.16846962 |
| 70 | rRNA processing (GO:0006364) | 3.13321408 |
| 71 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.10620493 |
| 72 | establishment of protein localization to mitochondrion (GO:0072655) | 3.09798230 |
| 73 | translational termination (GO:0006415) | 3.08772475 |
| 74 | rRNA metabolic process (GO:0016072) | 3.08495673 |
| 75 | cellular component biogenesis (GO:0044085) | 3.07308081 |
| 76 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 3.03398191 |
| 77 | positive regulation of fatty acid transport (GO:2000193) | 3.03323027 |
| 78 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.03054051 |
| 79 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.01643402 |
| 80 | protein localization to mitochondrion (GO:0070585) | 3.00053211 |
| 81 | CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369) | 2.99296315 |
| 82 | cotranslational protein targeting to membrane (GO:0006613) | 2.98950495 |
| 83 | tolerance induction (GO:0002507) | 2.98922103 |
| 84 | cullin deneddylation (GO:0010388) | 2.98557804 |
| 85 | protein targeting to ER (GO:0045047) | 2.97988218 |
| 86 | negative regulation of nitric oxide biosynthetic process (GO:0045019) | 2.97207124 |
| 87 | behavioral response to nicotine (GO:0035095) | 2.90340194 |
| 88 | translational elongation (GO:0006414) | 2.88298118 |
| 89 | regulation of female receptivity (GO:0045924) | 2.88058574 |
| 90 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 2.87703567 |
| 91 | positive regulation of icosanoid secretion (GO:0032305) | 2.86762748 |
| 92 | regulation of cellular amine metabolic process (GO:0033238) | 2.86313412 |
| 93 | hydrogen ion transmembrane transport (GO:1902600) | 2.85596317 |
| 94 | ribonucleoside triphosphate biosynthetic process (GO:0009201) | 2.84457838 |
| 95 | cytochrome complex assembly (GO:0017004) | 2.81234949 |
| 96 | positive regulation of cell cycle arrest (GO:0071158) | 2.79528136 |
| 97 | protein localization to endoplasmic reticulum (GO:0070972) | 2.79285689 |
| 98 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 2.77669978 |
| 99 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 2.76406574 |
| 100 | metallo-sulfur cluster assembly (GO:0031163) | 2.75011983 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 6.11055456 |
| 2 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 5.24874836 |
| 3 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 4.31696901 |
| 4 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.77420077 |
| 5 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.42698879 |
| 6 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 3.41060077 |
| 7 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.33408377 |
| 8 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.19903975 |
| 9 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.92753120 |
| 10 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 2.87552517 |
| 11 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.79638743 |
| 12 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.79359998 |
| 13 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.71992545 |
| 14 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.42258441 |
| 15 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 2.36420315 |
| 16 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.31466257 |
| 17 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.31355073 |
| 18 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.27253668 |
| 19 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.23384263 |
| 20 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 2.19364078 |
| 21 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.08374625 |
| 22 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.06613974 |
| 23 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.96027543 |
| 24 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.95058120 |
| 25 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.90704954 |
| 26 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.89162168 |
| 27 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.85268027 |
| 28 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.85230227 |
| 29 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.79427969 |
| 30 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.78654587 |
| 31 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.76076015 |
| 32 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.73601467 |
| 33 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.73516767 |
| 34 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.73096190 |
| 35 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.72632194 |
| 36 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.70796913 |
| 37 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.67680569 |
| 38 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.58505294 |
| 39 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.58149721 |
| 40 | EWS_26573619_Chip-Seq_HEK293_Human | 1.55172437 |
| 41 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.54527213 |
| 42 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.49002431 |
| 43 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.46332072 |
| 44 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.44660695 |
| 45 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.43074579 |
| 46 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.37714834 |
| 47 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.37442805 |
| 48 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.36154601 |
| 49 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.33234505 |
| 50 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.32415238 |
| 51 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.31187219 |
| 52 | VDR_22108803_ChIP-Seq_LS180_Human | 1.31181686 |
| 53 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.26380920 |
| 54 | LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.24750505 |
| 55 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.22567469 |
| 56 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.19645704 |
| 57 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.19645704 |
| 58 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.19069943 |
| 59 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.16597152 |
| 60 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.12538338 |
| 61 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.09902257 |
| 62 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.08377731 |
| 63 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 1.06390201 |
| 64 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.04571170 |
| 65 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.04519710 |
| 66 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 1.02874587 |
| 67 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.02321906 |
| 68 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 1.02302405 |
| 69 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.01384521 |
| 70 | GATA3_21878914_ChIP-Seq_MCF-7_Human | 1.01306566 |
| 71 | NCOR_22424771_ChIP-Seq_293T_Human | 1.00773868 |
| 72 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.00285648 |
| 73 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.99513926 |
| 74 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 0.98366666 |
| 75 | MYC_19829295_ChIP-Seq_ESCs_Human | 0.96805428 |
| 76 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 0.95564170 |
| 77 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.92481399 |
| 78 | TAF2_19829295_ChIP-Seq_ESCs_Human | 0.91885326 |
| 79 | EBNA1_20929547_Chip-Seq_RAJI-cells_Human | 0.91024410 |
| 80 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 0.90046851 |
| 81 | SALL4_22934838_ChIP-ChIP_CD34+_Human | 0.87998011 |
| 82 | FOXH1_21741376_ChIP-Seq_EPCs_Human | 0.87315549 |
| 83 | SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 0.85956171 |
| 84 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.85851193 |
| 85 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.83636237 |
| 86 | HOXB7_26014856_ChIP-Seq_BT474_Human | 0.82908805 |
| 87 | AR_20517297_ChIP-Seq_VCAP_Human | 0.82768615 |
| 88 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 0.81627888 |
| 89 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 0.81115168 |
| 90 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 0.80224071 |
| 91 | P53_21459846_ChIP-Seq_SAOS-2_Human | 0.79484980 |
| 92 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 0.79020619 |
| 93 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 0.78482954 |
| 94 | ERG_20517297_ChIP-Seq_VCAP_Human | 0.78174954 |
| 95 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.77504382 |
| 96 | GATA3_26560356_Chip-Seq_TH2_Human | 0.77454424 |
| 97 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 0.76378069 |
| 98 | TDRD3_21172665_ChIP-Seq_MCF-7_Human | 0.75946634 |
| 99 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 0.75641463 |
| 100 | STAT1_20625510_ChIP-Seq_HELA_Human | 0.74988680 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0001348_abnormal_lacrimal_gland | 4.30878175 |
| 2 | MP0005646_abnormal_pituitary_gland | 3.64540716 |
| 3 | MP0004147_increased_porphyrin_level | 3.42421954 |
| 4 | MP0002163_abnormal_gland_morphology | 3.38142949 |
| 5 | MP0002102_abnormal_ear_morphology | 3.03448176 |
| 6 | MP0000685_abnormal_immune_system | 2.93784541 |
| 7 | MP0001873_stomach_inflammation | 2.80915619 |
| 8 | MP0008875_abnormal_xenobiotic_pharmacok | 2.72450009 |
| 9 | MP0003646_muscle_fatigue | 2.48372663 |
| 10 | MP0008872_abnormal_physiological_respon | 2.43474746 |
| 11 | MP0006036_abnormal_mitochondrial_physio | 2.40936827 |
| 12 | MP0009333_abnormal_splenocyte_physiolog | 2.16638910 |
| 13 | MP0001835_abnormal_antigen_presentation | 1.96638332 |
| 14 | MP0005379_endocrine/exocrine_gland_phen | 1.93752978 |
| 15 | MP0001529_abnormal_vocalization | 1.88194135 |
| 16 | MP0005671_abnormal_response_to | 1.87916129 |
| 17 | MP0003011_delayed_dark_adaptation | 1.82780265 |
| 18 | MP0001968_abnormal_touch/_nociception | 1.80112366 |
| 19 | MP0003315_abnormal_perineum_morphology | 1.79542976 |
| 20 | MP0004885_abnormal_endolymph | 1.70050682 |
| 21 | MP0008877_abnormal_DNA_methylation | 1.68335771 |
| 22 | MP0002736_abnormal_nociception_after | 1.67195845 |
| 23 | MP0001790_abnormal_immune_system | 1.61631751 |
| 24 | MP0005387_immune_system_phenotype | 1.61631751 |
| 25 | MP0002006_tumorigenesis | 1.58834063 |
| 26 | MP0001984_abnormal_olfaction | 1.57880685 |
| 27 | MP0008789_abnormal_olfactory_epithelium | 1.56607307 |
| 28 | MP0003693_abnormal_embryo_hatching | 1.56244728 |
| 29 | MP0003718_maternal_effect | 1.53829742 |
| 30 | MP0005084_abnormal_gallbladder_morpholo | 1.50177150 |
| 31 | MP0005645_abnormal_hypothalamus_physiol | 1.49273501 |
| 32 | MP0003045_fibrosis | 1.49270243 |
| 33 | MP0004145_abnormal_muscle_electrophysio | 1.48907825 |
| 34 | MP0005187_abnormal_penis_morphology | 1.48287139 |
| 35 | MP0002138_abnormal_hepatobiliary_system | 1.44526144 |
| 36 | MP0002277_abnormal_respiratory_mucosa | 1.43630992 |
| 37 | MP0001346_abnormal_lacrimal_gland | 1.41290528 |
| 38 | MP0009764_decreased_sensitivity_to | 1.39899013 |
| 39 | MP0006276_abnormal_autonomic_nervous | 1.38727182 |
| 40 | MP0001440_abnormal_grooming_behavior | 1.35912425 |
| 41 | MP0002160_abnormal_reproductive_system | 1.35213282 |
| 42 | MP0006082_CNS_inflammation | 1.32581296 |
| 43 | MP0004142_abnormal_muscle_tone | 1.30607452 |
| 44 | MP0005167_abnormal_blood-brain_barrier | 1.29545356 |
| 45 | MP0003866_abnormal_defecation | 1.28152459 |
| 46 | MP0001986_abnormal_taste_sensitivity | 1.26858189 |
| 47 | MP0002166_altered_tumor_susceptibility | 1.25247652 |
| 48 | MP0003786_premature_aging | 1.24965006 |
| 49 | MP0001800_abnormal_humoral_immune | 1.18759805 |
| 50 | MP0003806_abnormal_nucleotide_metabolis | 1.18364126 |
| 51 | MP0004043_abnormal_pH_regulation | 1.17149845 |
| 52 | MP0002272_abnormal_nervous_system | 1.12525217 |
| 53 | MP0002733_abnormal_thermal_nociception | 1.12079661 |
| 54 | MP0002148_abnormal_hypersensitivity_rea | 1.11586342 |
| 55 | MP0002876_abnormal_thyroid_physiology | 1.11230830 |
| 56 | MP0005499_abnormal_olfactory_system | 1.10953596 |
| 57 | MP0005394_taste/olfaction_phenotype | 1.10953596 |
| 58 | MP0003186_abnormal_redox_activity | 1.09778325 |
| 59 | MP0008058_abnormal_DNA_repair | 1.08856080 |
| 60 | MP0003763_abnormal_thymus_physiology | 1.06221283 |
| 61 | MP0006035_abnormal_mitochondrial_morpho | 1.04642130 |
| 62 | MP0006292_abnormal_olfactory_placode | 1.04004414 |
| 63 | MP0001663_abnormal_digestive_system | 0.98334104 |
| 64 | MP0005389_reproductive_system_phenotype | 0.97952046 |
| 65 | MP0005551_abnormal_eye_electrophysiolog | 0.97067385 |
| 66 | MP0005000_abnormal_immune_tolerance | 0.96874284 |
| 67 | MP0005377_hearing/vestibular/ear_phenot | 0.96618829 |
| 68 | MP0003878_abnormal_ear_physiology | 0.96618829 |
| 69 | MP0003567_abnormal_fetal_cardiomyocyte | 0.95906162 |
| 70 | MP0001881_abnormal_mammary_gland | 0.94915742 |
| 71 | MP0000613_abnormal_salivary_gland | 0.92755553 |
| 72 | MP0008007_abnormal_cellular_replicative | 0.92158933 |
| 73 | MP0002723_abnormal_immune_serum | 0.87063979 |
| 74 | MP0004742_abnormal_vestibular_system | 0.86909417 |
| 75 | MP0009745_abnormal_behavioral_response | 0.86304605 |
| 76 | MP0010094_abnormal_chromosome_stability | 0.85556910 |
| 77 | MP0002735_abnormal_chemical_nociception | 0.84821188 |
| 78 | MP0006072_abnormal_retinal_apoptosis | 0.82785206 |
| 79 | MP0001293_anophthalmia | 0.81996547 |
| 80 | MP0003959_abnormal_lean_body | 0.79596793 |
| 81 | MP0003436_decreased_susceptibility_to | 0.79471832 |
| 82 | MP0005332_abnormal_amino_acid | 0.79335427 |
| 83 | MP0002405_respiratory_system_inflammati | 0.78512961 |
| 84 | MP0005310_abnormal_salivary_gland | 0.75978173 |
| 85 | MP0008775_abnormal_heart_ventricle | 0.75491309 |
| 86 | MP0001905_abnormal_dopamine_level | 0.75322127 |
| 87 | MP0001970_abnormal_pain_threshold | 0.74294756 |
| 88 | MP0008932_abnormal_embryonic_tissue | 0.74278799 |
| 89 | MP0000689_abnormal_spleen_morphology | 0.73176384 |
| 90 | MP0005448_abnormal_energy_balance | 0.72202782 |
| 91 | MP0009785_altered_susceptibility_to | 0.71532816 |
| 92 | MP0000631_abnormal_neuroendocrine_gland | 0.71284978 |
| 93 | MP0005636_abnormal_mineral_homeostasis | 0.70110126 |
| 94 | MP0000703_abnormal_thymus_morphology | 0.69747114 |
| 95 | MP0005083_abnormal_biliary_tract | 0.69629791 |
| 96 | MP0000230_abnormal_systemic_arterial | 0.67384539 |
| 97 | MP0003787_abnormal_imprinting | 0.67181887 |
| 98 | MP0001919_abnormal_reproductive_system | 0.64705391 |
| 99 | MP0004957_abnormal_blastocyst_morpholog | 0.63892318 |
| 100 | MP0003936_abnormal_reproductive_system | 0.63141169 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Increased hepatocellular lipid droplets (HP:0006565) | 4.51418025 |
| 2 | Acute necrotizing encephalopathy (HP:0006965) | 4.50480991 |
| 3 | Increased IgM level (HP:0003496) | 4.13612424 |
| 4 | Lipid accumulation in hepatocytes (HP:0006561) | 4.07569458 |
| 5 | Abnormal mitochondria in muscle tissue (HP:0008316) | 4.07027281 |
| 6 | Mitochondrial inheritance (HP:0001427) | 3.95571044 |
| 7 | Increased CSF lactate (HP:0002490) | 3.91670336 |
| 8 | Acute encephalopathy (HP:0006846) | 3.90780233 |
| 9 | Stomatitis (HP:0010280) | 3.88962000 |
| 10 | Increased intramyocellular lipid droplets (HP:0012240) | 3.77807986 |
| 11 | Renal Fanconi syndrome (HP:0001994) | 3.75589109 |
| 12 | Progressive macrocephaly (HP:0004481) | 3.65235571 |
| 13 | Exertional dyspnea (HP:0002875) | 3.31530376 |
| 14 | Congenital, generalized hypertrichosis (HP:0004540) | 3.20596126 |
| 15 | Increased serum lactate (HP:0002151) | 3.15975673 |
| 16 | Increased muscle lipid content (HP:0009058) | 3.13691368 |
| 17 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 3.12125540 |
| 18 | 3-Methylglutaconic aciduria (HP:0003535) | 3.03754703 |
| 19 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.87972137 |
| 20 | IgG deficiency (HP:0004315) | 2.86046895 |
| 21 | Absent/shortened dynein arms (HP:0200106) | 2.83698896 |
| 22 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 2.83698896 |
| 23 | Septo-optic dysplasia (HP:0100842) | 2.81364162 |
| 24 | Cerebral edema (HP:0002181) | 2.80021177 |
| 25 | Molar tooth sign on MRI (HP:0002419) | 2.79414610 |
| 26 | Abnormality of midbrain morphology (HP:0002418) | 2.79414610 |
| 27 | Nephronophthisis (HP:0000090) | 2.79410142 |
| 28 | Abnormality of the labia minora (HP:0012880) | 2.78785321 |
| 29 | Colon cancer (HP:0003003) | 2.76340719 |
| 30 | Optic disc pallor (HP:0000543) | 2.74881067 |
| 31 | Progressive microcephaly (HP:0000253) | 2.68008484 |
| 32 | Abnormality of the renal medulla (HP:0100957) | 2.54244082 |
| 33 | Respiratory difficulties (HP:0002880) | 2.52339310 |
| 34 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 2.46204861 |
| 35 | Abnormality of T cell physiology (HP:0011840) | 2.45922003 |
| 36 | Abnormality of cells of the erythroid lineage (HP:0012130) | 2.45534669 |
| 37 | Lactic acidosis (HP:0003128) | 2.43577038 |
| 38 | Hepatocellular necrosis (HP:0001404) | 2.42919582 |
| 39 | Abnormal number of erythroid precursors (HP:0012131) | 2.42082330 |
| 40 | Aplasia/Hypoplasia of the spleen (HP:0010451) | 2.39331585 |
| 41 | Hypochromic anemia (HP:0001931) | 2.36909341 |
| 42 | Exercise intolerance (HP:0003546) | 2.35872051 |
| 43 | Asplenia (HP:0001746) | 2.35177466 |
| 44 | Optic nerve coloboma (HP:0000588) | 2.35093193 |
| 45 | Hypochromic microcytic anemia (HP:0004840) | 2.34370537 |
| 46 | Congenital stationary night blindness (HP:0007642) | 2.34221761 |
| 47 | Hepatic necrosis (HP:0002605) | 2.31652509 |
| 48 | Hypoplasia of the pons (HP:0012110) | 2.30127250 |
| 49 | Abnormality of the pons (HP:0007361) | 2.27870957 |
| 50 | Abnormality of the renal cortex (HP:0011035) | 2.26878801 |
| 51 | Abnormality of renal resorption (HP:0011038) | 2.26341686 |
| 52 | Macrocytic anemia (HP:0001972) | 2.25912563 |
| 53 | Abnormal rod and cone electroretinograms (HP:0008323) | 2.25536259 |
| 54 | Neuroendocrine neoplasm (HP:0100634) | 2.24731502 |
| 55 | Polydipsia (HP:0001959) | 2.22851782 |
| 56 | Abnormal drinking behavior (HP:0030082) | 2.22851782 |
| 57 | Pancreatic cysts (HP:0001737) | 2.21756671 |
| 58 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.20198152 |
| 59 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.20198152 |
| 60 | Cerebral hypomyelination (HP:0006808) | 2.17651152 |
| 61 | Autoimmune hemolytic anemia (HP:0001890) | 2.17261240 |
| 62 | Tubulointerstitial nephritis (HP:0001970) | 2.16691326 |
| 63 | Elevated erythrocyte sedimentation rate (HP:0003565) | 2.15420732 |
| 64 | Reticulocytopenia (HP:0001896) | 2.11987546 |
| 65 | Abnormal ciliary motility (HP:0012262) | 2.08584558 |
| 66 | Lethargy (HP:0001254) | 2.07053037 |
| 67 | Methylmalonic acidemia (HP:0002912) | 2.06453370 |
| 68 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.04278357 |
| 69 | Abnormality of alanine metabolism (HP:0010916) | 2.04278357 |
| 70 | Hyperalaninemia (HP:0003348) | 2.04278357 |
| 71 | Respiratory failure (HP:0002878) | 2.02325675 |
| 72 | Bile duct proliferation (HP:0001408) | 2.01912048 |
| 73 | Abnormal biliary tract physiology (HP:0012439) | 2.01912048 |
| 74 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 2.00626370 |
| 75 | Pendular nystagmus (HP:0012043) | 1.98380430 |
| 76 | Abnormal respiratory epithelium morphology (HP:0012253) | 1.98021943 |
| 77 | Abnormal respiratory motile cilium morphology (HP:0005938) | 1.98021943 |
| 78 | Renal cortical cysts (HP:0000803) | 1.97620938 |
| 79 | Neutropenia (HP:0001875) | 1.94395867 |
| 80 | Glycosuria (HP:0003076) | 1.93705304 |
| 81 | Abnormality of urine glucose concentration (HP:0011016) | 1.93705304 |
| 82 | Cleft eyelid (HP:0000625) | 1.91872759 |
| 83 | Abnormality of T cells (HP:0002843) | 1.91835998 |
| 84 | Optic nerve hypoplasia (HP:0000609) | 1.89640228 |
| 85 | Leukodystrophy (HP:0002415) | 1.88835341 |
| 86 | Absent septum pellucidum (HP:0001331) | 1.88371251 |
| 87 | Aplasia/Hypoplasia of the optic nerve (HP:0008058) | 1.87135145 |
| 88 | True hermaphroditism (HP:0010459) | 1.86772541 |
| 89 | CNS hypomyelination (HP:0003429) | 1.85762628 |
| 90 | Neoplasm of head and neck (HP:0012288) | 1.84977740 |
| 91 | Esophageal neoplasm (HP:0100751) | 1.84977740 |
| 92 | Type 2 muscle fiber atrophy (HP:0003554) | 1.83782130 |
| 93 | Tinnitus (HP:0000360) | 1.81413989 |
| 94 | Stomach cancer (HP:0012126) | 1.81034633 |
| 95 | Pancreatic fibrosis (HP:0100732) | 1.80905025 |
| 96 | Rhinitis (HP:0012384) | 1.78719207 |
| 97 | Methylmalonic aciduria (HP:0012120) | 1.78241572 |
| 98 | Pallor (HP:0000980) | 1.77749177 |
| 99 | Posterior subcapsular cataract (HP:0007787) | 1.77244229 |
| 100 | Abnormality of the vocal cords (HP:0008777) | 1.73548984 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TSSK6 | 3.85894443 |
| 2 | VRK2 | 3.54918137 |
| 3 | NUAK1 | 3.06219249 |
| 4 | PBK | 2.95251478 |
| 5 | TXK | 2.86979318 |
| 6 | TLK1 | 2.62737098 |
| 7 | BUB1 | 2.60301677 |
| 8 | EIF2AK3 | 2.56644912 |
| 9 | WNK4 | 2.51634712 |
| 10 | ZAK | 2.49504442 |
| 11 | TIE1 | 2.42012629 |
| 12 | GRK1 | 2.41910821 |
| 13 | NEK1 | 2.36605542 |
| 14 | EIF2AK1 | 2.24777839 |
| 15 | STK16 | 2.13058269 |
| 16 | ADRBK2 | 2.12040357 |
| 17 | NME2 | 2.00041121 |
| 18 | PLK3 | 1.89257520 |
| 19 | EIF2AK2 | 1.81430932 |
| 20 | VRK1 | 1.68070763 |
| 21 | BMPR1B | 1.64006862 |
| 22 | CDK8 | 1.57282375 |
| 23 | NME1 | 1.56083160 |
| 24 | PDK2 | 1.44061802 |
| 25 | IKBKE | 1.41234247 |
| 26 | IKBKB | 1.39439508 |
| 27 | TGFBR2 | 1.35424334 |
| 28 | MST4 | 1.31948716 |
| 29 | SRPK1 | 1.31119809 |
| 30 | BCR | 1.27631804 |
| 31 | MAP2K2 | 1.25280812 |
| 32 | STK39 | 1.25100420 |
| 33 | WNK3 | 1.24355944 |
| 34 | TNIK | 1.23437360 |
| 35 | OXSR1 | 1.21588669 |
| 36 | PIK3CA | 1.16626044 |
| 37 | DYRK2 | 1.15417130 |
| 38 | FES | 1.14758199 |
| 39 | KIT | 1.11518741 |
| 40 | BCKDK | 1.11084888 |
| 41 | PLK2 | 1.09577380 |
| 42 | FRK | 1.05541958 |
| 43 | CDC7 | 1.04032221 |
| 44 | CSNK1G2 | 1.03134840 |
| 45 | TAOK3 | 0.95074175 |
| 46 | MAP3K14 | 0.91405099 |
| 47 | BRD4 | 0.84887883 |
| 48 | DAPK1 | 0.83803267 |
| 49 | STK4 | 0.82319268 |
| 50 | CSNK1G3 | 0.77193144 |
| 51 | GRK7 | 0.76365964 |
| 52 | MAP2K6 | 0.72713001 |
| 53 | TBK1 | 0.71106343 |
| 54 | PAK3 | 0.69142108 |
| 55 | ALK | 0.63978678 |
| 56 | CDK19 | 0.63937766 |
| 57 | ADRBK1 | 0.63071318 |
| 58 | DAPK2 | 0.59376588 |
| 59 | TEC | 0.57494697 |
| 60 | PRKCG | 0.56787448 |
| 61 | CSNK1G1 | 0.55395298 |
| 62 | TAF1 | 0.53717437 |
| 63 | PLK1 | 0.53176461 |
| 64 | CAMKK2 | 0.52995333 |
| 65 | CSNK1A1L | 0.51967819 |
| 66 | PIM2 | 0.51957435 |
| 67 | CSNK2A2 | 0.51431755 |
| 68 | PHKG2 | 0.51352992 |
| 69 | PHKG1 | 0.51352992 |
| 70 | GRK5 | 0.50133581 |
| 71 | ABL2 | 0.49694523 |
| 72 | PIK3CG | 0.48731805 |
| 73 | MARK3 | 0.48436281 |
| 74 | ATR | 0.48375175 |
| 75 | PAK4 | 0.47909446 |
| 76 | INSRR | 0.47735703 |
| 77 | MAP4K2 | 0.43515766 |
| 78 | WNK1 | 0.42794164 |
| 79 | TGFBR1 | 0.41742334 |
| 80 | STK38L | 0.41709398 |
| 81 | MAPK13 | 0.41584644 |
| 82 | TRIM28 | 0.40411432 |
| 83 | CAMK1D | 0.40389620 |
| 84 | PRKCQ | 0.40127180 |
| 85 | RPS6KA5 | 0.39878737 |
| 86 | PRKCI | 0.39812806 |
| 87 | BRSK2 | 0.39752149 |
| 88 | LCK | 0.38963289 |
| 89 | CSNK2A1 | 0.38822617 |
| 90 | AURKB | 0.37602990 |
| 91 | CAMK2A | 0.37071497 |
| 92 | RPS6KA1 | 0.35822355 |
| 93 | SYK | 0.35254258 |
| 94 | WEE1 | 0.34740312 |
| 95 | ERBB2 | 0.34692694 |
| 96 | PAK6 | 0.34156125 |
| 97 | STK24 | 0.34027373 |
| 98 | CHEK2 | 0.33836375 |
| 99 | CSNK1E | 0.33621559 |
| 100 | MINK1 | 0.33567730 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 5.01198618 |
| 2 | Ribosome_Homo sapiens_hsa03010 | 3.89267386 |
| 3 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.64275808 |
| 4 | Parkinsons disease_Homo sapiens_hsa05012 | 3.22412862 |
| 5 | Protein export_Homo sapiens_hsa03060 | 2.99942997 |
| 6 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.86575708 |
| 7 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.58446554 |
| 8 | Asthma_Homo sapiens_hsa05310 | 2.44436987 |
| 9 | RNA polymerase_Homo sapiens_hsa03020 | 2.37109211 |
| 10 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 2.23705414 |
| 11 | Alzheimers disease_Homo sapiens_hsa05010 | 2.15464335 |
| 12 | Huntingtons disease_Homo sapiens_hsa05016 | 2.15052402 |
| 13 | Allograft rejection_Homo sapiens_hsa05330 | 2.10562365 |
| 14 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.96877341 |
| 15 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.95964239 |
| 16 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.95174460 |
| 17 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.85587603 |
| 18 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.80374029 |
| 19 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.67287815 |
| 20 | Sulfur relay system_Homo sapiens_hsa04122 | 1.62850580 |
| 21 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.61803356 |
| 22 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.58929094 |
| 23 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.58499096 |
| 24 | RNA degradation_Homo sapiens_hsa03018 | 1.43060845 |
| 25 | RNA transport_Homo sapiens_hsa03013 | 1.36651907 |
| 26 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.31984118 |
| 27 | DNA replication_Homo sapiens_hsa03030 | 1.28964278 |
| 28 | Spliceosome_Homo sapiens_hsa03040 | 1.25849231 |
| 29 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.22966916 |
| 30 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.22371539 |
| 31 | Homologous recombination_Homo sapiens_hsa03440 | 1.19582532 |
| 32 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.18388903 |
| 33 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.18186305 |
| 34 | Basal transcription factors_Homo sapiens_hsa03022 | 1.16387839 |
| 35 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.13282363 |
| 36 | Mismatch repair_Homo sapiens_hsa03430 | 1.09221566 |
| 37 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.07104590 |
| 38 | Phototransduction_Homo sapiens_hsa04744 | 1.05096339 |
| 39 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.04137302 |
| 40 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.98531754 |
| 41 | Base excision repair_Homo sapiens_hsa03410 | 0.97851167 |
| 42 | Nucleotide excision repair_Homo sapiens_hsa03420 | 0.97675420 |
| 43 | Peroxisome_Homo sapiens_hsa04146 | 0.95917676 |
| 44 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.93842292 |
| 45 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.89416508 |
| 46 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.87670660 |
| 47 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.81661906 |
| 48 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.80285146 |
| 49 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.77483984 |
| 50 | Purine metabolism_Homo sapiens_hsa00230 | 0.75910729 |
| 51 | Nicotine addiction_Homo sapiens_hsa05033 | 0.74717119 |
| 52 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.72699682 |
| 53 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.72608040 |
| 54 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.71519495 |
| 55 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.70903869 |
| 56 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.70539788 |
| 57 | Metabolic pathways_Homo sapiens_hsa01100 | 0.67621168 |
| 58 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.67408211 |
| 59 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.67214162 |
| 60 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.64867383 |
| 61 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.64721844 |
| 62 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.62694233 |
| 63 | Retinol metabolism_Homo sapiens_hsa00830 | 0.62600118 |
| 64 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.61755942 |
| 65 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.58546364 |
| 66 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.57038351 |
| 67 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.55003812 |
| 68 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.54775661 |
| 69 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.54172288 |
| 70 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.54055657 |
| 71 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.54039043 |
| 72 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.51504667 |
| 73 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.50449613 |
| 74 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.49465185 |
| 75 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.46602116 |
| 76 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.45793001 |
| 77 | Mineral absorption_Homo sapiens_hsa04978 | 0.45556087 |
| 78 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.45371403 |
| 79 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.45293620 |
| 80 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.43052730 |
| 81 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.42749404 |
| 82 | Legionellosis_Homo sapiens_hsa05134 | 0.41716686 |
| 83 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.41264024 |
| 84 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.40539579 |
| 85 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.39372615 |
| 86 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.37368498 |
| 87 | Carbon metabolism_Homo sapiens_hsa01200 | 0.36878751 |
| 88 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.36551712 |
| 89 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.35447081 |
| 90 | Olfactory transduction_Homo sapiens_hsa04740 | 0.35310762 |
| 91 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.31706024 |
| 92 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.31362636 |
| 93 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.30482758 |
| 94 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.30343974 |
| 95 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.29685838 |
| 96 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.29105335 |
| 97 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.28949851 |
| 98 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.28017366 |
| 99 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.27064343 |
| 100 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.26988060 |

