ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	4.96726531
2	regulation of response to tumor cell (GO:0002834)	4.88615393
3	positive regulation of response to tumor cell (GO:0002836)	4.88615393
4	positive regulation of immune response to tumor cell (GO:0002839)	4.88615393
5	regulation of immune response to tumor cell (GO:0002837)	4.88615393
6	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.72150003
7	water-soluble vitamin biosynthetic process (GO:0042364)	4.57834389
8	proteasome assembly (GO:0043248)	4.35423232
9	rRNA modification (GO:0000154)	3.95623115
10	cellular ketone body metabolic process (GO:0046950)	3.77306394
11	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.62951395
12	peptidyl-histidine modification (GO:0018202)	3.62522292
13	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.59759652
14	replication fork processing (GO:0031297)	3.59693026
15	rRNA methylation (GO:0031167)	3.53991654
16	respiratory chain complex IV assembly (GO:0008535)	3.50611503
17	regulation of cellular amino acid metabolic process (GO:0006521)	3.48126240
18	ketone body metabolic process (GO:1902224)	3.43835838
19	GMP metabolic process (GO:0046037)	3.39754959
20	lactate metabolic process (GO:0006089)	3.39373972
21	DNA double-strand break processing (GO:0000729)	3.38505826
22	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	3.34599434
23	platelet dense granule organization (GO:0060155)	3.31911189
24	regulation of hexokinase activity (GO:1903299)	3.30058093
25	regulation of glucokinase activity (GO:0033131)	3.30058093
26	pseudouridine synthesis (GO:0001522)	3.28911234
27	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	3.28163028
28	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	3.28163028
29	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	3.28163028
30	cullin deneddylation (GO:0010388)	3.23469350
31	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	3.23318916
32	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	3.23318916
33	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.21958250
34	signal peptide processing (GO:0006465)	3.16692398
35	kinetochore assembly (GO:0051382)	3.15291659
36	protein complex biogenesis (GO:0070271)	3.15221444
37	protein deneddylation (GO:0000338)	3.12481272
38	cytochrome complex assembly (GO:0017004)	3.10256438
39	CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)	3.10044514
40	DNA strand renaturation (GO:0000733)	3.07443784
41	kynurenine metabolic process (GO:0070189)	3.07362283
42	nucleotide transmembrane transport (GO:1901679)	3.05771702
43	signal transduction involved in DNA integrity checkpoint (GO:0072401)	3.05420857
44	signal transduction involved in DNA damage checkpoint (GO:0072422)	3.05420857
45	serotonin receptor signaling pathway (GO:0007210)	3.04041601
46	establishment of integrated proviral latency (GO:0075713)	3.02083218
47	signal transduction involved in cell cycle checkpoint (GO:0072395)	3.00227764
48	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.98860764
49	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.97425609
50	mitochondrial respiratory chain complex assembly (GO:0033108)	2.95590468
51	negative regulation of acute inflammatory response (GO:0002674)	2.89024728
52	mannosylation (GO:0097502)	2.86586346
53	CENP-A containing nucleosome assembly (GO:0034080)	2.86221183
54	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.85956912
55	NADH dehydrogenase complex assembly (GO:0010257)	2.85956912
56	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.85956912
57	cellular response to interferon-beta (GO:0035458)	2.80249322
58	response to X-ray (GO:0010165)	2.78934028
59	chromatin remodeling at centromere (GO:0031055)	2.78451782
60	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.77455838
61	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.77399381
62	T cell mediated immunity (GO:0002456)	2.77015788
63	cytidine deamination (GO:0009972)	2.76267502
64	cytidine metabolic process (GO:0046087)	2.76267502
65	cytidine catabolic process (GO:0006216)	2.76267502
66	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.75979148
67	termination of RNA polymerase III transcription (GO:0006386)	2.75979148
68	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.73888594
69	tRNA processing (GO:0008033)	2.72066424
70	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.70682117
71	negative regulation of ligase activity (GO:0051352)	2.70682117
72	piRNA metabolic process (GO:0034587)	2.69295852
73	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.69271309
74	CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)	2.68120374
75	T-helper cell differentiation (GO:0042093)	2.68120374
76	tryptophan catabolic process (GO:0006569)	2.67632716
77	indole-containing compound catabolic process (GO:0042436)	2.67632716
78	indolalkylamine catabolic process (GO:0046218)	2.67632716
79	tricarboxylic acid cycle (GO:0006099)	2.67479049
80	protein K6-linked ubiquitination (GO:0085020)	2.65854322
81	aldehyde catabolic process (GO:0046185)	2.62884659
82	attachment of spindle microtubules to kinetochore (GO:0008608)	2.61790642
83	L-methionine biosynthetic process (GO:0071265)	2.57970090
84	amino acid salvage (GO:0043102)	2.57970090
85	L-methionine salvage (GO:0071267)	2.57970090
86	adenosine metabolic process (GO:0046085)	2.57006491
87	tRNA metabolic process (GO:0006399)	2.56271439
88	tryptophan metabolic process (GO:0006568)	2.55494244
89	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.54551352
90	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.54551352
91	glutathione derivative biosynthetic process (GO:1901687)	2.53935787
92	glutathione derivative metabolic process (GO:1901685)	2.53935787
93	regulation of helicase activity (GO:0051095)	2.53163643
94	histone exchange (GO:0043486)	2.52513793
95	postreplication repair (GO:0006301)	2.51491822
96	negative regulation of T-helper cell differentiation (GO:0045623)	2.51450108
97	negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)	2.51450108
98	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.49062925
99	maturation of 5.8S rRNA (GO:0000460)	2.48399319
100	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.47794339

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	5.12052324
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.26690973
3	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.47806854
4	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.45080279
5	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.88588820
6	ZNF274_21170338_ChIP-Seq_K562_Hela	2.76800429
7	VDR_22108803_ChIP-Seq_LS180_Human	2.75596843
8	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.69931649
9	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.67052041
10	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.34522960
11	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.30834639
12	ELK1_19687146_ChIP-ChIP_HELA_Human	2.29957631
13	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.20232115
14	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.19717820
15	VDR_23849224_ChIP-Seq_CD4+_Human	2.18972623
16	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.16906181
17	FOXP3_21729870_ChIP-Seq_TREG_Human	2.04703311
18	EWS_26573619_Chip-Seq_HEK293_Human	2.00790507
19	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.97064051
20	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.91439145
21	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.89844697
22	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.87718964
23	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.87426817
24	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.86035604
25	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.84716735
26	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.81498404
27	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.81213506
28	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.79827909
29	IGF1R_20145208_ChIP-Seq_DFB_Human	1.77946021
30	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.76265805
31	MYC_18940864_ChIP-ChIP_HL60_Human	1.62823714
32	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.61346844
33	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.57842291
34	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.55970679
35	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.54799689
36	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.53703394
37	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.51673063
38	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.50559378
39	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.48564790
40	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.42042431
41	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.41808933
42	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.40139778
43	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.39424628
44	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.39424628
45	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.34497525
46	P300_19829295_ChIP-Seq_ESCs_Human	1.29811285
47	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.28882087
48	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.28300199
49	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.28255170
50	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.28092521
51	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.27606226
52	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.25838489
53	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.25499263
54	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.24884428
55	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.23935728
56	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.23887720
57	SOX2_19829295_ChIP-Seq_ESCs_Human	1.22816719
58	NANOG_19829295_ChIP-Seq_ESCs_Human	1.22816719
59	IRF1_19129219_ChIP-ChIP_H3396_Human	1.22625536
60	TP53_22573176_ChIP-Seq_HFKS_Human	1.21955614
61	AR_20517297_ChIP-Seq_VCAP_Human	1.19755498
62	FUS_26573619_Chip-Seq_HEK293_Human	1.18372171
63	TCF4_22108803_ChIP-Seq_LS180_Human	1.17595914
64	ER_23166858_ChIP-Seq_MCF-7_Human	1.17436553
65	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.17336724
66	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.13586199
67	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.12018321
68	CDX2_22108803_ChIP-Seq_LS180_Human	1.07143179
69	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.07001442
70	HTT_18923047_ChIP-ChIP_STHdh_Human	1.06827330
71	HOXB7_26014856_ChIP-Seq_BT474_Human	1.06637564
72	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.06328791
73	SALL4_22934838_ChIP-ChIP_CD34+_Human	1.05469457
74	DCP1A_22483619_ChIP-Seq_HELA_Human	1.04948970
75	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.04027904
76	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.03067818
77	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.00939946
78	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.00913504
79	NCOR_22424771_ChIP-Seq_293T_Human	1.00108877
80	GABP_19822575_ChIP-Seq_HepG2_Human	0.98674181
81	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.98393027
82	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	0.97890370
83	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.97199232
84	GATA3_26560356_Chip-Seq_TH2_Human	0.97140800
85	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.96894342
86	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.96791756
87	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.96302396
88	PHF8_20622853_ChIP-Seq_HELA_Human	0.96014069
89	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.94576832
90	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.93680490
91	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.93369807
92	RBPJ_21746931_ChIP-Seq_IB4_Human	0.91157449
93	TAF15_26573619_Chip-Seq_HEK293_Human	0.90326142
94	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.88139180
95	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	0.87860466
96	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.87755172
97	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.87694697
98	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.87567388
99	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.87179749
100	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.86535862

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001986_abnormal_taste_sensitivity	4.39490306
2	MP0008875_abnormal_xenobiotic_pharmacok	3.88464250
3	MP0000372_irregular_coat_pigmentation	3.81303229
4	MP0003136_yellow_coat_color	3.15445481
5	MP0003806_abnormal_nucleotide_metabolis	3.14502231
6	MP0002163_abnormal_gland_morphology	3.06373334
7	MP0002102_abnormal_ear_morphology	2.94140391
8	MP0005171_absent_coat_pigmentation	2.91668948
9	MP0005075_abnormal_melanosome_morpholog	2.48735546
10	MP0005379_endocrine/exocrine_gland_phen	2.46554854
11	MP0002138_abnormal_hepatobiliary_system	2.39275838
12	MP0005408_hypopigmentation	2.33868706
13	MP0006082_CNS_inflammation	2.32090511
14	MP0003718_maternal_effect	2.31863258
15	MP0008872_abnormal_physiological_respon	2.16053787
16	MP0004381_abnormal_hair_follicle	2.15012414
17	MP0002938_white_spotting	2.10891024
18	MP0002876_abnormal_thyroid_physiology	2.10059600
19	MP0001348_abnormal_lacrimal_gland	2.05404713
20	MP0002736_abnormal_nociception_after	1.99239601
21	MP0002837_dystrophic_cardiac_calcinosis	1.98162848
22	MP0003186_abnormal_redox_activity	1.97763529
23	MP0005167_abnormal_blood-brain_barrier	1.94794565
24	MP0005174_abnormal_tail_pigmentation	1.92023271
25	MP0006036_abnormal_mitochondrial_physio	1.88336663
26	MP0000015_abnormal_ear_pigmentation	1.76105902
27	MP0003195_calcinosis	1.75114897
28	MP0006035_abnormal_mitochondrial_morpho	1.74775598
29	MP0005671_abnormal_response_to	1.70374402
30	MP0005084_abnormal_gallbladder_morpholo	1.70214251
31	MP0005551_abnormal_eye_electrophysiolog	1.64073552
32	MP0001968_abnormal_touch/_nociception	1.63856392
33	MP0004885_abnormal_endolymph	1.54452688
34	MP0008877_abnormal_DNA_methylation	1.52091301
35	MP0001764_abnormal_homeostasis	1.49071085
36	MP0003786_premature_aging	1.46989033
37	MP0010094_abnormal_chromosome_stability	1.46229107
38	MP0008058_abnormal_DNA_repair	1.45901134
39	MP0004145_abnormal_muscle_electrophysio	1.44927239
40	MP0008007_abnormal_cellular_replicative	1.38648173
41	MP0002166_altered_tumor_susceptibility	1.28765631
42	MP0003787_abnormal_imprinting	1.27595930
43	MP0003646_muscle_fatigue	1.22554400
44	MP0002877_abnormal_melanocyte_morpholog	1.21189729
45	MP0010329_abnormal_lipoprotein_level	1.21111048
46	MP0004019_abnormal_vitamin_homeostasis	1.20722237
47	MP0002234_abnormal_pharynx_morphology	1.20401734
48	MP0001501_abnormal_sleep_pattern	1.16746238
49	MP0009046_muscle_twitch	1.10813680
50	MP0002006_tumorigenesis	1.09621832
51	MP0000685_abnormal_immune_system	1.09322393
52	MP0002139_abnormal_hepatobiliary_system	1.08454033
53	MP0004957_abnormal_blastocyst_morpholog	1.08439116
54	MP0005253_abnormal_eye_physiology	1.08027462
55	MP0003693_abnormal_embryo_hatching	1.07813616
56	MP0006054_spinal_hemorrhage	1.06849177
57	MP0009333_abnormal_splenocyte_physiolog	0.99488363
58	MP0001485_abnormal_pinna_reflex	0.98833038
59	MP0008775_abnormal_heart_ventricle	0.98749401
60	MP0001873_stomach_inflammation	0.98683327
61	MP0001835_abnormal_antigen_presentation	0.98371315
62	MP0002095_abnormal_skin_pigmentation	0.96874782
63	MP0000569_abnormal_digit_pigmentation	0.93228786
64	MP0002638_abnormal_pupillary_reflex	0.92266089
65	MP0005365_abnormal_bile_salt	0.90276923
66	MP0005646_abnormal_pituitary_gland	0.89120197
67	MP0002272_abnormal_nervous_system	0.87316356
68	MP0005332_abnormal_amino_acid	0.86981163
69	MP0005395_other_phenotype	0.85095950
70	MP0000371_diluted_coat_color	0.84018777
71	MP0008873_increased_physiological_sensi	0.82936240
72	MP0006072_abnormal_retinal_apoptosis	0.80897907
73	MP0005085_abnormal_gallbladder_physiolo	0.80095955
74	MP0002751_abnormal_autonomic_nervous	0.79481581
75	MP0005387_immune_system_phenotype	0.77438883
76	MP0001790_abnormal_immune_system	0.77438883
77	MP0005330_cardiomyopathy	0.76824747
78	MP0000427_abnormal_hair_cycle	0.75582787
79	MP0009697_abnormal_copulation	0.75255645
80	MP0005410_abnormal_fertilization	0.74070026
81	MP0009745_abnormal_behavioral_response	0.74028165
82	MP0001293_anophthalmia	0.73684269
83	MP0005266_abnormal_metabolism	0.72374606
84	MP0004142_abnormal_muscle_tone	0.71988769
85	MP0001984_abnormal_olfaction	0.71049796
86	MP0004147_increased_porphyrin_level	0.70272167
87	MP0005310_abnormal_salivary_gland	0.69730976
88	MP0003111_abnormal_nucleus_morphology	0.69521069
89	MP0004215_abnormal_myocardial_fiber	0.68948955
90	MP0005389_reproductive_system_phenotype	0.68942682
91	MP0003567_abnormal_fetal_cardiomyocyte	0.68656414
92	MP0002148_abnormal_hypersensitivity_rea	0.66380588
93	MP0000358_abnormal_cell_content/	0.63761607
94	MP0001324_abnormal_eye_pigmentation	0.63466680
95	MP0003011_delayed_dark_adaptation	0.61892680
96	MP0003880_abnormal_central_pattern	0.60967683
97	MP0001929_abnormal_gametogenesis	0.60862996
98	MP0000613_abnormal_salivary_gland	0.60624372
99	MP0006276_abnormal_autonomic_nervous	0.58984960
100	MP0005636_abnormal_mineral_homeostasis	0.58684792

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	4.27837011
2	Abnormality of alanine metabolism (HP:0010916)	4.27837011
3	Hyperalaninemia (HP:0003348)	4.27837011
4	Increased CSF lactate (HP:0002490)	3.20947134
5	Acute necrotizing encephalopathy (HP:0006965)	3.14833917
6	Pancreatic cysts (HP:0001737)	3.10703049
7	Hypoplasia of the fovea (HP:0007750)	3.08810939
8	Aplasia/Hypoplasia of the fovea (HP:0008060)	3.08810939
9	Increased serum lactate (HP:0002151)	3.02719928
10	Abnormality of the renal cortex (HP:0011035)	3.02045018
11	Colon cancer (HP:0003003)	2.99879650
12	Abolished electroretinogram (ERG) (HP:0000550)	2.96455277
13	Progressive macrocephaly (HP:0004481)	2.95562988
14	Increased serum pyruvate (HP:0003542)	2.95193505
15	Acute encephalopathy (HP:0006846)	2.92308277
16	Hypoplasia of the uterus (HP:0000013)	2.91027877
17	Hepatocellular necrosis (HP:0001404)	2.87403964
18	Aplasia/hypoplasia of the uterus (HP:0008684)	2.86395323
19	Constricted visual fields (HP:0001133)	2.79600530
20	Spontaneous abortion (HP:0005268)	2.79598800
21	Abnormality of glycolysis (HP:0004366)	2.79141712
22	Congenital stationary night blindness (HP:0007642)	2.78202943
23	Optic disc pallor (HP:0000543)	2.77905509
24	Large for gestational age (HP:0001520)	2.76983011
25	Mitochondrial inheritance (HP:0001427)	2.73009702
26	Hepatic necrosis (HP:0002605)	2.67822035
27	Abnormal mitochondria in muscle tissue (HP:0008316)	2.65228614
28	Attenuation of retinal blood vessels (HP:0007843)	2.63473867
29	Abnormal rod and cone electroretinograms (HP:0008323)	2.62849627
30	Abnormality of the fovea (HP:0000493)	2.60021908
31	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.59963085
32	Pancreatic fibrosis (HP:0100732)	2.56638153
33	Abnormality of serum amino acid levels (HP:0003112)	2.51554895
34	Hypoplastic pelvis (HP:0008839)	2.48205801
35	Decreased central vision (HP:0007663)	2.47229384
36	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.44986995
37	Pendular nystagmus (HP:0012043)	2.41423993
38	Cerebral edema (HP:0002181)	2.39645421
39	Pancreatic islet-cell hyperplasia (HP:0004510)	2.36723819
40	Cutaneous melanoma (HP:0012056)	2.34887970
41	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.34658475
42	Hyperglycinuria (HP:0003108)	2.34111351
43	Increased IgM level (HP:0003496)	2.33331079
44	Congenital sensorineural hearing impairment (HP:0008527)	2.31722565
45	Abnormal biliary tract physiology (HP:0012439)	2.29816189
46	Bile duct proliferation (HP:0001408)	2.29816189
47	Lethargy (HP:0001254)	2.23137722
48	Dyschromatopsia (HP:0007641)	2.21150492
49	Hypoproteinemia (HP:0003075)	2.21117534
50	Progressive inability to walk (HP:0002505)	2.20246410
51	Lactic acidosis (HP:0003128)	2.19719450
52	Abnormality of the renal medulla (HP:0100957)	2.17818259
53	True hermaphroditism (HP:0010459)	2.17323818
54	Abnormality of the labia minora (HP:0012880)	2.16332742
55	Albinism (HP:0001022)	2.15545998
56	CNS demyelination (HP:0007305)	2.13449946
57	Abnormal biliary tract morphology (HP:0012440)	2.12335036
58	Hyperglycinemia (HP:0002154)	2.09539442
59	Supernumerary spleens (HP:0009799)	2.08616137
60	Eosinophilia (HP:0001880)	2.08194729
61	Hyperglycemia (HP:0003074)	2.08093440
62	Patchy hypopigmentation of hair (HP:0011365)	2.06446513
63	Epidermoid cyst (HP:0200040)	2.04444453
64	Polyuria (HP:0000103)	2.01434056
65	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.96714099
66	Patent foramen ovale (HP:0001655)	1.94529425
67	Central scotoma (HP:0000603)	1.93799037
68	Neoplasm of the adrenal gland (HP:0100631)	1.91861174
69	Respiratory failure (HP:0002878)	1.90960542
70	Increased corneal curvature (HP:0100692)	1.89350211
71	Keratoconus (HP:0000563)	1.89350211
72	Aplasia/Hypoplasia of the macula (HP:0008059)	1.88307980
73	Abnormality of methionine metabolism (HP:0010901)	1.87875369
74	Intestinal atresia (HP:0011100)	1.86442107
75	Nephronophthisis (HP:0000090)	1.86306720
76	IgG deficiency (HP:0004315)	1.86212508
77	Metabolic alkalosis (HP:0200114)	1.84945030
78	Polydipsia (HP:0001959)	1.84516584
79	Abnormal drinking behavior (HP:0030082)	1.84516584
80	Autoimmune hemolytic anemia (HP:0001890)	1.83347438
81	Biliary tract neoplasm (HP:0100574)	1.83230878
82	Tubulointerstitial fibrosis (HP:0005576)	1.80128423
83	Autoimmune thrombocytopenia (HP:0001973)	1.78491003
84	Hypokalemic alkalosis (HP:0001949)	1.78420886
85	Renal cortical cysts (HP:0000803)	1.77930526
86	White forelock (HP:0002211)	1.77515982
87	Ketoacidosis (HP:0001993)	1.77054523
88	Macular degeneration (HP:0000608)	1.76050920
89	Abnormal spermatogenesis (HP:0008669)	1.75991821
90	Abnormality of T cell physiology (HP:0011840)	1.75882429
91	3-Methylglutaconic aciduria (HP:0003535)	1.75260532
92	Leukodystrophy (HP:0002415)	1.74632862
93	Lipid accumulation in hepatocytes (HP:0006561)	1.74580358
94	Hypothermia (HP:0002045)	1.73723597
95	Stomach cancer (HP:0012126)	1.73329421
96	Ependymoma (HP:0002888)	1.73247664
97	Aplasia/Hypoplasia affecting the retina (HP:0008061)	1.73230993
98	Melanoma (HP:0002861)	1.72591431
99	Amaurosis fugax (HP:0100576)	1.72315130
100	Methylmalonic aciduria (HP:0012120)	1.70428055

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TIE1	4.77107517
2	BUB1	3.77339625
3	NUAK1	3.44579142
4	PDK2	3.42376980
5	VRK2	3.37454643
6	PBK	3.20557997
7	FRK	3.14722319
8	GRK1	2.36022871
9	TAF1	2.33680365
10	BCR	2.22197312
11	MAP4K2	2.10094788
12	MST4	2.07565751
13	NEK1	2.07321264
14	ZAK	1.97661331
15	TRIM28	1.89336703
16	BMPR1B	1.78620240
17	EIF2AK3	1.76807050
18	TSSK6	1.61316201
19	ADRBK2	1.59459069
20	WNK3	1.58650795
21	VRK1	1.56075223
22	PLK3	1.55213165
23	BCKDK	1.52077731
24	EIF2AK1	1.51537038
25	TGFBR2	1.47746511
26	TNIK	1.46589272
27	PLK2	1.41798244
28	FER	1.28383190
29	PLK4	1.27366775
30	CSNK1G3	1.23302639
31	OXSR1	1.19856035
32	CSNK1G1	1.18136366
33	TXK	1.17521895
34	MKNK1	1.14668403
35	STK38L	1.14027162
36	TGFBR1	1.07603162
37	MKNK2	1.07387354
38	MAP3K12	1.05381893
39	TEC	1.04695490
40	PHKG1	1.00818947
41	PHKG2	1.00818947
42	TLK1	1.00405266
43	ACVR1B	0.96671329
44	DAPK1	0.94353491
45	AKT3	0.92419777
46	CSNK1A1L	0.91362609
47	MAPKAPK5	0.90284706
48	SRPK1	0.89850578
49	CSNK1G2	0.89034834
50	MARK3	0.88767664
51	IKBKB	0.84222206
52	STK16	0.82297412
53	CCNB1	0.78823471
54	STK3	0.77611100
55	FES	0.76513737
56	GRK5	0.74901671
57	MYLK	0.68322777
58	TAOK3	0.65496425
59	NLK	0.61919442
60	PRKCI	0.60385571
61	FGFR2	0.60384376
62	NME1	0.59341014
63	PTK2B	0.55482140
64	PRKCE	0.54564422
65	CDK19	0.53833743
66	PAK3	0.52726648
67	KIT	0.52366523
68	DYRK2	0.52336979
69	TTK	0.52248546
70	STK39	0.52019549
71	ALK	0.49126610
72	NEK2	0.48002085
73	MAP4K1	0.47936343
74	STK4	0.45861096
75	DAPK2	0.45321114
76	WEE1	0.44699479
77	EIF2AK2	0.43457909
78	PLK1	0.42277036
79	INSRR	0.40138223
80	CDC7	0.39857227
81	PRKCG	0.39213449
82	PRKAA2	0.37859801
83	ATR	0.37855025
84	PINK1	0.37679925
85	CAMK2D	0.37607936
86	CSNK1A1	0.35717239
87	RPS6KA5	0.34498585
88	GSK3A	0.34421957
89	PASK	0.33344713
90	CDK8	0.32067293
91	BRSK2	0.29092591
92	AURKB	0.27642940
93	SMG1	0.26102335
94	MAPK13	0.24563598
95	CSNK2A1	0.24404723
96	ADRBK1	0.23258091
97	PRKG1	0.22051242
98	MAP3K3	0.21607877
99	DAPK3	0.21556258
100	FGFR1	0.21043422

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.98113456
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.00118067
3	Caffeine metabolism_Homo sapiens_hsa00232	2.67048330
4	Non-homologous end-joining_Homo sapiens_hsa03450	2.52116582
5	Protein export_Homo sapiens_hsa03060	2.40296956
6	Mismatch repair_Homo sapiens_hsa03430	2.21779555
7	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.10584386
8	RNA polymerase_Homo sapiens_hsa03020	2.03760050
9	One carbon pool by folate_Homo sapiens_hsa00670	1.96049513
10	Allograft rejection_Homo sapiens_hsa05330	1.93473424
11	Oxidative phosphorylation_Homo sapiens_hsa00190	1.88748392
12	Propanoate metabolism_Homo sapiens_hsa00640	1.86500830
13	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.85714099
14	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.84513768
15	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.77957010
16	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.75550369
17	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.71607840
18	Butanoate metabolism_Homo sapiens_hsa00650	1.65237947
19	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.62732390
20	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.61927366
21	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.60737719
22	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.60142138
23	Homologous recombination_Homo sapiens_hsa03440	1.59790733
24	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.57018651
25	RNA degradation_Homo sapiens_hsa03018	1.56142869
26	Tryptophan metabolism_Homo sapiens_hsa00380	1.54237720
27	Asthma_Homo sapiens_hsa05310	1.54040537
28	Pyruvate metabolism_Homo sapiens_hsa00620	1.48527035
29	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.47395579
30	Fatty acid elongation_Homo sapiens_hsa00062	1.47213545
31	Linoleic acid metabolism_Homo sapiens_hsa00591	1.45156504
32	Parkinsons disease_Homo sapiens_hsa05012	1.43142808
33	Phototransduction_Homo sapiens_hsa04744	1.38141389
34	Glutathione metabolism_Homo sapiens_hsa00480	1.37176444
35	DNA replication_Homo sapiens_hsa03030	1.34473483
36	Nucleotide excision repair_Homo sapiens_hsa03420	1.26673627
37	Steroid biosynthesis_Homo sapiens_hsa00100	1.26090390
38	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.20498112
39	Selenocompound metabolism_Homo sapiens_hsa00450	1.19033882
40	Fanconi anemia pathway_Homo sapiens_hsa03460	1.15933968
41	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.15006944
42	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.14441631
43	Type I diabetes mellitus_Homo sapiens_hsa04940	1.13083281
44	Fat digestion and absorption_Homo sapiens_hsa04975	1.11679138
45	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.11058324
46	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.10852928
47	Chemical carcinogenesis_Homo sapiens_hsa05204	1.07967675
48	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.07436716
49	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.06706240
50	Basal transcription factors_Homo sapiens_hsa03022	1.05745105
51	Ether lipid metabolism_Homo sapiens_hsa00565	1.05551799
52	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.04470365
53	RNA transport_Homo sapiens_hsa03013	1.03419232
54	Antigen processing and presentation_Homo sapiens_hsa04612	1.01670134
55	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.99657026
56	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.99226042
57	Fatty acid degradation_Homo sapiens_hsa00071	0.99056385
58	Carbon metabolism_Homo sapiens_hsa01200	0.94220603
59	Purine metabolism_Homo sapiens_hsa00230	0.93546303
60	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.93348705
61	Pyrimidine metabolism_Homo sapiens_hsa00240	0.93302347
62	Sulfur metabolism_Homo sapiens_hsa00920	0.93080020
63	Peroxisome_Homo sapiens_hsa04146	0.92569531
64	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.92157148
65	Nitrogen metabolism_Homo sapiens_hsa00910	0.91738665
66	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.87260542
67	Huntingtons disease_Homo sapiens_hsa05016	0.84732004
68	Base excision repair_Homo sapiens_hsa03410	0.83899083
69	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.81358355
70	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.78389016
71	Retinol metabolism_Homo sapiens_hsa00830	0.76639785
72	Graft-versus-host disease_Homo sapiens_hsa05332	0.76047812
73	Spliceosome_Homo sapiens_hsa03040	0.73307976
74	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.71575224
75	Primary immunodeficiency_Homo sapiens_hsa05340	0.70221109
76	Alzheimers disease_Homo sapiens_hsa05010	0.69749365
77	Collecting duct acid secretion_Homo sapiens_hsa04966	0.69426532
78	Metabolic pathways_Homo sapiens_hsa01100	0.66081666
79	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.65677270
80	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.63473941
81	Mineral absorption_Homo sapiens_hsa04978	0.60112083
82	beta-Alanine metabolism_Homo sapiens_hsa00410	0.60106944
83	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.58757376
84	Fatty acid metabolism_Homo sapiens_hsa01212	0.57059881
85	Arginine and proline metabolism_Homo sapiens_hsa00330	0.55416432
86	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.53264477
87	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.52231685
88	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.51721905
89	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.43881431
90	Rheumatoid arthritis_Homo sapiens_hsa05323	0.42399263
91	Glycerolipid metabolism_Homo sapiens_hsa00561	0.40473474
92	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.37937889
93	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.36491275
94	PPAR signaling pathway_Homo sapiens_hsa03320	0.36325325
95	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.35567325
96	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.35525520
97	Histidine metabolism_Homo sapiens_hsa00340	0.35205387
98	Galactose metabolism_Homo sapiens_hsa00052	0.28306209
99	Olfactory transduction_Homo sapiens_hsa04740	0.25290342
100	African trypanosomiasis_Homo sapiens_hsa05143	0.24091016

GAPDHP32

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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