GAPDHP33

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)7.36710445
2ATP synthesis coupled proton transport (GO:0015986)6.39024013
3energy coupled proton transport, down electrochemical gradient (GO:0015985)6.39024013
4mitochondrial respiratory chain complex I assembly (GO:0032981)5.09708551
5NADH dehydrogenase complex assembly (GO:0010257)5.09708551
6mitochondrial respiratory chain complex I biogenesis (GO:0097031)5.09708551
7platelet dense granule organization (GO:0060155)5.03665824
8DNA strand renaturation (GO:0000733)4.98052766
9establishment of protein localization to mitochondrial membrane (GO:0090151)4.80575299
10mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.80232059
11cullin deneddylation (GO:0010388)4.52165235
12blood vessel maturation (GO:0001955)4.52100910
13chaperone-mediated protein transport (GO:0072321)4.51351068
14protein complex biogenesis (GO:0070271)4.43904927
15respiratory electron transport chain (GO:0022904)4.43840237
16electron transport chain (GO:0022900)4.33653295
17proteasome assembly (GO:0043248)4.23685682
18regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)4.13371399
19regulation of mitotic spindle checkpoint (GO:1903504)4.13371399
20respiratory chain complex IV assembly (GO:0008535)3.99360725
21pyrimidine-containing compound transmembrane transport (GO:0072531)3.98154138
22mitochondrial respiratory chain complex assembly (GO:0033108)3.89931259
23protein deneddylation (GO:0000338)3.81947882
24establishment of integrated proviral latency (GO:0075713)3.81665151
25nucleotide transmembrane transport (GO:1901679)3.77074356
26viral mRNA export from host cell nucleus (GO:0046784)3.74519974
27cytochrome complex assembly (GO:0017004)3.59555784
28ATP biosynthetic process (GO:0006754)3.58533142
29aldehyde catabolic process (GO:0046185)3.56681864
30phagocytosis, recognition (GO:0006910)3.53500118
31regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.52704540
32signal peptide processing (GO:0006465)3.52133832
33DNA damage response, detection of DNA damage (GO:0042769)3.49821246
34GMP metabolic process (GO:0046037)3.48097805
35positive regulation of T cell chemotaxis (GO:0010820)3.47516126
36regulation of T cell chemotaxis (GO:0010819)3.47516126
37establishment of viral latency (GO:0019043)3.45115555
38hydrogen ion transmembrane transport (GO:1902600)3.41622629
39protein neddylation (GO:0045116)3.39920042
40ER overload response (GO:0006983)3.38527818
41multicellular organism reproduction (GO:0032504)3.37281241
42female mating behavior (GO:0060180)3.36619167
43L-fucose catabolic process (GO:0042355)3.35632945
44fucose catabolic process (GO:0019317)3.35632945
45L-fucose metabolic process (GO:0042354)3.35632945
46inner mitochondrial membrane organization (GO:0007007)3.34975510
47organelle membrane fusion (GO:0090174)3.34733577
48regulation of RIG-I signaling pathway (GO:0039535)3.34328199
49multicellular organismal aging (GO:0010259)3.33254899
50oxidative phosphorylation (GO:0006119)3.32889599
51adaptation of signaling pathway (GO:0023058)3.31450944
52positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.30928267
53proton transport (GO:0015992)3.29818963
54purine nucleoside triphosphate biosynthetic process (GO:0009145)3.28496292
55purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.27348488
56protein peptidyl-prolyl isomerization (GO:0000413)3.25548641
57hydrogen transport (GO:0006818)3.23217680
58macrophage differentiation (GO:0030225)3.21720439
59endosome to melanosome transport (GO:0035646)3.21119710
60endosome to pigment granule transport (GO:0043485)3.21119710
61positive regulation of prostaglandin secretion (GO:0032308)3.20458628
62regulation of cilium movement (GO:0003352)3.20290461
63acrosome reaction (GO:0007340)3.20287561
64rRNA modification (GO:0000154)3.12461283
65regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.03935690
66neuromuscular synaptic transmission (GO:0007274)3.02169933
67pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.97265428
68ribonucleoside triphosphate biosynthetic process (GO:0009201)2.94734536
69nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.93889158
70protein localization to mitochondrion (GO:0070585)2.92051033
71protein polyglutamylation (GO:0018095)2.90727079
72response to pheromone (GO:0019236)2.90029334
73exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.86241763
74negative regulation of meiosis (GO:0045835)2.84623581
75positive regulation of natural killer cell differentiation (GO:0032825)2.84238019
76fusion of sperm to egg plasma membrane (GO:0007342)2.83510140
77protein targeting to mitochondrion (GO:0006626)2.82188226
78behavioral response to nicotine (GO:0035095)2.79245340
79negative regulation of telomere maintenance (GO:0032205)2.79169325
80histone mRNA metabolic process (GO:0008334)2.78132509
81termination of RNA polymerase III transcription (GO:0006386)2.77912534
82transcription elongation from RNA polymerase III promoter (GO:0006385)2.77912534
83deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.76752474
84peptidyl-proline modification (GO:0018208)2.76450508
85somatic hypermutation of immunoglobulin genes (GO:0016446)2.75750796
86somatic diversification of immune receptors via somatic mutation (GO:0002566)2.75750796
87positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.68759796
88nucleoside triphosphate biosynthetic process (GO:0009142)2.67740255
89fucose metabolic process (GO:0006004)2.67016398
90cytokine biosynthetic process (GO:0042089)2.67005922
91disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.66128582
92killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.66128582
93establishment of protein localization to mitochondrion (GO:0072655)2.65174794
94short-chain fatty acid metabolic process (GO:0046459)2.64368052
95anterograde synaptic vesicle transport (GO:0048490)2.62202033
96regulation of protein kinase A signaling (GO:0010738)2.61445995
97activation of adenylate cyclase activity (GO:0007190)2.60217171
98purine nucleoside monophosphate biosynthetic process (GO:0009127)2.59994132
99purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.59994132
100base-excision repair, AP site formation (GO:0006285)2.59516941

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.53829968
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.60153631
3EST1_17652178_ChIP-ChIP_JURKAT_Human4.27275285
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.24629034
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.66333582
6ELF1_17652178_ChIP-ChIP_JURKAT_Human3.57749531
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.42571009
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.25174700
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.95409811
10ELK1_19687146_ChIP-ChIP_HELA_Human2.87338516
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.31213057
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.24960487
13BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.18405400
14VDR_23849224_ChIP-Seq_CD4+_Human2.18034750
15SRF_21415370_ChIP-Seq_HL-1_Mouse2.10615633
16PADI4_21655091_ChIP-ChIP_MCF-7_Human2.08950372
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.05500894
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.00938887
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.91816637
20PCGF2_27294783_Chip-Seq_ESCs_Mouse1.82226871
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.74087796
22LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.68971225
23PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.64796828
24ZNF274_21170338_ChIP-Seq_K562_Hela1.62923811
25VDR_22108803_ChIP-Seq_LS180_Human1.60781305
26GABP_19822575_ChIP-Seq_HepG2_Human1.57463037
27P300_19829295_ChIP-Seq_ESCs_Human1.57390204
28PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.56144755
29MYC_18555785_ChIP-Seq_MESCs_Mouse1.52167471
30THAP11_20581084_ChIP-Seq_MESCs_Mouse1.51021104
31EWS_26573619_Chip-Seq_HEK293_Human1.46106951
32FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.44945447
33FOXP3_21729870_ChIP-Seq_TREG_Human1.44907425
34DCP1A_22483619_ChIP-Seq_HELA_Human1.43091621
35RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.41201106
36FUS_26573619_Chip-Seq_HEK293_Human1.35693221
37SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.35606274
38MYC_18358816_ChIP-ChIP_MESCs_Mouse1.35500847
39HOXB4_20404135_ChIP-ChIP_EML_Mouse1.31622614
40STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.31471026
41MYC_18940864_ChIP-ChIP_HL60_Human1.30071491
42CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.29751301
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27079624
44PCGF2_27294783_Chip-Seq_NPCs_Mouse1.27071200
45GATA2_21666600_ChIP-Seq_HMVEC_Human1.25854684
46BCAT_22108803_ChIP-Seq_LS180_Human1.24665338
47YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.21564214
48MYC_19030024_ChIP-ChIP_MESCs_Mouse1.19234661
49ZFP57_27257070_Chip-Seq_ESCs_Mouse1.18783919
50SUZ12_27294783_Chip-Seq_NPCs_Mouse1.17067036
51CTBP2_25329375_ChIP-Seq_LNCAP_Human1.14303625
52CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.14196053
53ETV2_25802403_ChIP-Seq_MESCs_Mouse1.10996166
54GBX2_23144817_ChIP-Seq_PC3_Human1.10685737
55XRN2_22483619_ChIP-Seq_HELA_Human1.10560561
56EZH2_27294783_Chip-Seq_NPCs_Mouse1.08244931
57HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.07309041
58PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.06549722
59E2F1_18555785_ChIP-Seq_MESCs_Mouse1.06011553
60CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.05552089
61NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.05438983
62POU3F2_20337985_ChIP-ChIP_501MEL_Human1.03702761
63NFE2_27457419_Chip-Seq_LIVER_Mouse1.03067895
64E2F4_17652178_ChIP-ChIP_JURKAT_Human1.02486117
65SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.01060471
66CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.99825186
67MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.99452399
68BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.97625390
69EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.97143636
70TP53_22573176_ChIP-Seq_HFKS_Human0.96057128
71EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.95247954
72NANOG_19829295_ChIP-Seq_ESCs_Human0.93038297
73SOX2_19829295_ChIP-Seq_ESCs_Human0.93038297
74LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.92914707
75EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.91545765
76ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.90882924
77IGF1R_20145208_ChIP-Seq_DFB_Human0.89682384
78GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.89670656
79MYC_19829295_ChIP-Seq_ESCs_Human0.88798306
80RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.86744927
81FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86613240
82FOXA1_27270436_Chip-Seq_PROSTATE_Human0.84821888
83FOXA1_25329375_ChIP-Seq_VCAP_Human0.84821888
84HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.84549163
85KDM5A_27292631_Chip-Seq_BREAST_Human0.84397409
86SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.83237057
87TTF2_22483619_ChIP-Seq_HELA_Human0.83200717
88CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82001497
89CRX_20693478_ChIP-Seq_RETINA_Mouse0.81629464
90CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.81500460
91POU5F1_16153702_ChIP-ChIP_HESCs_Human0.81491652
92RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.81256824
93AUTS2_25519132_ChIP-Seq_293T-REX_Human0.81151409
94ELK1_22589737_ChIP-Seq_MCF10A_Human0.80424537
95AR_20517297_ChIP-Seq_VCAP_Human0.80128802
96SMAD4_21799915_ChIP-Seq_A2780_Human0.79722480
97FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.79437508
98TAF15_26573619_Chip-Seq_HEK293_Human0.79356804
99TCF4_23295773_ChIP-Seq_U87_Human0.79320349
100AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.78737117

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation4.33832593
2MP0006054_spinal_hemorrhage4.31933616
3MP0000372_irregular_coat_pigmentation3.79344080
4MP0004147_increased_porphyrin_level3.31229083
5MP0000015_abnormal_ear_pigmentation2.93343566
6MP0005174_abnormal_tail_pigmentation2.63827111
7MP0000569_abnormal_digit_pigmentation2.55023660
8MP0009379_abnormal_foot_pigmentation2.45946094
9MP0003806_abnormal_nucleotide_metabolis2.42362573
10MP0003283_abnormal_digestive_organ2.42262667
11MP0003787_abnormal_imprinting2.41349261
12MP0003011_delayed_dark_adaptation2.40182185
13MP0001529_abnormal_vocalization2.24917070
14MP0005310_abnormal_salivary_gland2.23575958
15MP0003950_abnormal_plasma_membrane2.14701524
16MP0003315_abnormal_perineum_morphology2.11821662
17MP0006276_abnormal_autonomic_nervous2.03121064
18MP0005187_abnormal_penis_morphology2.02453483
19MP0005075_abnormal_melanosome_morpholog1.98703700
20MP0005360_urolithiasis1.89252097
21MP0003195_calcinosis1.81886651
22MP0000749_muscle_degeneration1.81871251
23MP0003186_abnormal_redox_activity1.78768890
24MP0004142_abnormal_muscle_tone1.77577412
25MP0001984_abnormal_olfaction1.70165168
26MP0000383_abnormal_hair_follicle1.64530502
27MP0003880_abnormal_central_pattern1.61934908
28MP0002095_abnormal_skin_pigmentation1.61293315
29MP0004510_myositis1.59558788
30MP0004043_abnormal_pH_regulation1.57863305
31MP0002751_abnormal_autonomic_nervous1.55892830
32MP0003868_abnormal_feces_composition1.54474432
33MP0008058_abnormal_DNA_repair1.54197559
34MP0005451_abnormal_body_composition1.52221202
35MP0002090_abnormal_vision1.51388878
36MP0006036_abnormal_mitochondrial_physio1.49380721
37MP0005551_abnormal_eye_electrophysiolog1.48877229
38MP0010386_abnormal_urinary_bladder1.47451325
39MP0005253_abnormal_eye_physiology1.44567677
40MP0005408_hypopigmentation1.42669707
41MP0009046_muscle_twitch1.40464480
42MP0002909_abnormal_adrenal_gland1.37297972
43MP0001851_eye_inflammation1.31805124
44MP0008877_abnormal_DNA_methylation1.29895971
45MP0009745_abnormal_behavioral_response1.29325596
46MP0005410_abnormal_fertilization1.27958652
47MP0002163_abnormal_gland_morphology1.26622999
48MP0001968_abnormal_touch/_nociception1.25698779
49MP0004484_altered_response_of1.25601055
50MP0006035_abnormal_mitochondrial_morpho1.24245554
51MP0003718_maternal_effect1.12868174
52MP0002938_white_spotting1.12514802
53MP0000358_abnormal_cell_content/1.10794895
54MP0002254_reproductive_system_inflammat1.07316567
55MP0002272_abnormal_nervous_system1.06161222
56MP0005167_abnormal_blood-brain_barrier1.06111254
57MP0001879_abnormal_lymphatic_vessel1.04740704
58MP0004145_abnormal_muscle_electrophysio1.01934239
59MP0003172_abnormal_lysosome_physiology1.01532135
60MP0000647_abnormal_sebaceous_gland0.97084722
61MP0002876_abnormal_thyroid_physiology0.95135351
62MP0008872_abnormal_physiological_respon0.94903765
63MP0002108_abnormal_muscle_morphology0.93106755
64MP0003633_abnormal_nervous_system0.89314029
65MP0004742_abnormal_vestibular_system0.87677275
66MP0002184_abnormal_innervation0.86031691
67MP0006072_abnormal_retinal_apoptosis0.80489005
68MP0005085_abnormal_gallbladder_physiolo0.78561751
69MP0004215_abnormal_myocardial_fiber0.78094508
70MP0002064_seizures0.76695232
71MP0002837_dystrophic_cardiac_calcinosis0.75237981
72MP0002269_muscular_atrophy0.72216311
73MP0002735_abnormal_chemical_nociception0.72035475
74MP0000613_abnormal_salivary_gland0.71994565
75MP0008007_abnormal_cellular_replicative0.71339982
76MP0002067_abnormal_sensory_capabilities0.70383800
77MP0005395_other_phenotype0.69912200
78MP0003638_abnormal_response/metabolism_0.69489607
79MP0005503_abnormal_tendon_morphology0.69291192
80MP0009697_abnormal_copulation0.68239186
81MP0003646_muscle_fatigue0.67971893
82MP0001756_abnormal_urination0.66540803
83MP0008057_abnormal_DNA_replication0.66176736
84MP0000538_abnormal_urinary_bladder0.64502916
85MP0005266_abnormal_metabolism0.64355883
86MP0005165_increased_susceptibility_to0.64135730
87MP0001790_abnormal_immune_system0.63796493
88MP0005387_immune_system_phenotype0.63796493
89MP0001324_abnormal_eye_pigmentation0.63520214
90MP0005645_abnormal_hypothalamus_physiol0.63104065
91MP0002006_tumorigenesis0.62776857
92MP0005171_absent_coat_pigmentation0.62702073
93MP0005220_abnormal_exocrine_pancreas0.61729614
94MP0002736_abnormal_nociception_after0.61222894
95MP0002148_abnormal_hypersensitivity_rea0.60399461
96MP0001501_abnormal_sleep_pattern0.60349409
97MP0004924_abnormal_behavior0.60037521
98MP0005386_behavior/neurological_phenoty0.60037521
99MP0001485_abnormal_pinna_reflex0.59252223
100MP0010678_abnormal_skin_adnexa0.54459772

Predicted human phenotypes

RankGene SetZ-score
1Hepatocellular necrosis (HP:0001404)5.66789483
2Acute necrotizing encephalopathy (HP:0006965)5.54192051
3Acute encephalopathy (HP:0006846)5.46486646
4Mitochondrial inheritance (HP:0001427)5.32467166
5Hepatic necrosis (HP:0002605)4.85145360
6Increased CSF lactate (HP:0002490)4.74430845
7Abnormal mitochondria in muscle tissue (HP:0008316)4.72335776
8Progressive macrocephaly (HP:0004481)4.41839989
9Congenital stationary night blindness (HP:0007642)4.11677516
10Muscle fiber atrophy (HP:0100295)4.07847017
11Abnormality of the labia minora (HP:0012880)4.03730256
12Type 2 muscle fiber atrophy (HP:0003554)3.94791098
13Abnormal number of erythroid precursors (HP:0012131)3.58788436
14Respiratory failure (HP:0002878)3.40392524
15Cerebral edema (HP:0002181)3.40284637
16Abnormal hair whorl (HP:0010721)3.24588694
173-Methylglutaconic aciduria (HP:0003535)3.20645542
18Colon cancer (HP:0003003)3.20377139
19Limb dystonia (HP:0002451)3.18585243
20Abnormality of cells of the erythroid lineage (HP:0012130)2.87220695
21Pancreatic cysts (HP:0001737)2.85880107
22Medial flaring of the eyebrow (HP:0010747)2.82915826
23Constricted visual fields (HP:0001133)2.80067680
24Decreased electroretinogram (ERG) amplitude (HP:0000654)2.79639392
25Emotional lability (HP:0000712)2.79213502
26Optic disc pallor (HP:0000543)2.78232766
27Increased serum lactate (HP:0002151)2.77386039
28Poor suck (HP:0002033)2.75219180
29Abnormality of the anterior horn cell (HP:0006802)2.71384183
30Degeneration of anterior horn cells (HP:0002398)2.71384183
31Aplastic anemia (HP:0001915)2.64032720
32Lactic acidosis (HP:0003128)2.63702860
33Abnormality of midbrain morphology (HP:0002418)2.49637975
34Molar tooth sign on MRI (HP:0002419)2.49637975
35Decreased central vision (HP:0007663)2.48312085
36Hypothermia (HP:0002045)2.47927489
37Parakeratosis (HP:0001036)2.47539096
38Pancreatic fibrosis (HP:0100732)2.46520699
39Conjunctival telangiectasia (HP:0000524)2.39243407
40Aplasia/Hypoplasia of the tibia (HP:0005772)2.37476943
41CNS demyelination (HP:0007305)2.32938116
42Weak cry (HP:0001612)2.31981713
43Congenital primary aphakia (HP:0007707)2.31524499
44Lipid accumulation in hepatocytes (HP:0006561)2.30525203
45Leukodystrophy (HP:0002415)2.30323152
46Gait imbalance (HP:0002141)2.27228494
47Agammaglobulinemia (HP:0004432)2.25946370
48Neutropenia (HP:0001875)2.24360016
49Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.21474520
50Type I transferrin isoform profile (HP:0003642)2.20432861
51Lethargy (HP:0001254)2.19978214
52Ulnar claw (HP:0001178)2.18243103
53Abnormality of the vasculature of the conjunctiva (HP:0008054)2.17470581
54Increased hepatocellular lipid droplets (HP:0006565)2.16278008
55Methylmalonic aciduria (HP:0012120)2.16271951
56Methylmalonic acidemia (HP:0002912)2.08539489
57Abnormal biliary tract physiology (HP:0012439)2.07477468
58Bile duct proliferation (HP:0001408)2.07477468
59Renal Fanconi syndrome (HP:0001994)2.04155956
60Delayed CNS myelination (HP:0002188)2.03236679
61Fatigable weakness (HP:0003473)2.02011410
62Abnormality of the neuromuscular junction (HP:0003398)2.02011410
63Tubular atrophy (HP:0000092)2.01978597
64Abnormality of the renal medulla (HP:0100957)2.01943050
65Abnormality of the renal cortex (HP:0011035)2.00603984
66Cone-rod dystrophy (HP:0000548)1.97260768
67Exercise intolerance (HP:0003546)1.95969596
68Nephronophthisis (HP:0000090)1.93890058
69True hermaphroditism (HP:0010459)1.92295203
70Increased intramyocellular lipid droplets (HP:0012240)1.92227250
71Pheochromocytoma (HP:0002666)1.90999058
72Microvesicular hepatic steatosis (HP:0001414)1.89819241
73Cerebral hemorrhage (HP:0001342)1.87065810
74Vacuolated lymphocytes (HP:0001922)1.85888846
75Bilateral microphthalmos (HP:0007633)1.85842323
76Dicarboxylic aciduria (HP:0003215)1.85499731
77Abnormality of dicarboxylic acid metabolism (HP:0010995)1.85499731
78Renal cortical cysts (HP:0000803)1.80114878
79Abnormality of lateral ventricle (HP:0030047)1.76935155
80Keratoconjunctivitis (HP:0001096)1.76253113
81Short tibia (HP:0005736)1.76116636
82Nephrogenic diabetes insipidus (HP:0009806)1.75528316
83Absent rod-and cone-mediated responses on ERG (HP:0007688)1.74982198
84Sensory axonal neuropathy (HP:0003390)1.73977657
85Tubulointerstitial fibrosis (HP:0005576)1.73526638
86Gaze-evoked nystagmus (HP:0000640)1.73422408
87Nausea (HP:0002018)1.73102590
88X-linked dominant inheritance (HP:0001423)1.71354463
89Blindness (HP:0000618)1.70886229
90Neuroendocrine neoplasm (HP:0100634)1.70702807
91Glycosuria (HP:0003076)1.68544660
92Abnormality of urine glucose concentration (HP:0011016)1.68544660
93Genital tract atresia (HP:0001827)1.64903498
94Supernumerary spleens (HP:0009799)1.64701043
95Left ventricular hypertrophy (HP:0001712)1.62593879
96Abnormal rod and cone electroretinograms (HP:0008323)1.62295598
97Abnormality of macular pigmentation (HP:0008002)1.61433300
98Increased muscle lipid content (HP:0009058)1.60690402
99Attenuation of retinal blood vessels (HP:0007843)1.59260119
100Hyperalaninemia (HP:0003348)1.56877507

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK28.73900200
2EIF2AK33.26632077
3MAP3K122.99161022
4SIK32.81040839
5VRK12.75480776
6BMPR1B2.62494368
7FRK2.56879882
8TAF12.41785359
9NUAK12.40958931
10EIF2AK12.00053756
11MAP4K21.94688092
12MAPKAPK51.76233741
13MYLK1.64884725
14DAPK11.62538584
15GRK71.60180699
16PASK1.49335486
17GRK11.47021678
18TSSK61.44626552
19TRIM281.36782662
20MARK11.34669965
21KSR11.31630843
22PLK21.21624433
23CASK1.21527888
24MAP3K131.20994132
25TAOK31.20279777
26ADRBK21.19002924
27MST41.15269651
28PRKCG1.11399195
29SMG11.09834495
30MAP3K91.09643421
31GRK51.07518256
32STK161.06244082
33TGFBR11.04711502
34CDC71.04566644
35CDK81.03048313
36PLK30.99275046
37WNK30.98359650
38NTRK30.96731020
39PIK3CG0.91633059
40IRAK30.91272097
41MAPK40.88933668
42NME10.87398047
43MAP3K30.86983596
44FES0.84744092
45MAPKAPK30.83764102
46MAPK130.83558149
47DAPK30.81173101
48PDK20.80333490
49PINK10.78133058
50EPHA40.78123853
51NEK10.75826547
52BUB10.74408252
53DDR20.72741980
54DYRK20.72029824
55PAK30.70810609
56NEK90.69803388
57PRKCE0.69565563
58NME20.69365943
59ADRBK10.69204949
60STK390.64504793
61TESK20.59264902
62OXSR10.58088696
63CAMK2A0.53182830
64CAMK2G0.52499139
65GRK60.51673251
66CSNK1G10.49439927
67CSNK1G30.49412587
68MKNK10.43593085
69MARK30.43543298
70CDK60.41381380
71ARAF0.41238197
72DYRK30.41205055
73CLK10.40099418
74TIE10.39067576
75PLK10.38875043
76PAK60.37484021
77PRKCI0.36315973
78TRPM70.36124889
79CDK40.35941528
80KSR20.35882901
81KIT0.35254522
82MKNK20.34289882
83MAP3K110.34175229
84INSRR0.33513503
85EIF2AK20.33130755
86SRPK10.33039118
87TNIK0.32479834
88LIMK10.29418959
89GSK3A0.29381165
90PBK0.27213087
91RPS6KA50.27207511
92CSNK1G20.27167527
93PTK2B0.26201494
94KDR0.26092152
95CSNK1A1L0.25229584
96PRKACB0.25108599
97DYRK1A0.24681088
98TGFBR20.23387131
99CSNK2A10.23311690
100PRKAA20.22905642

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.94713684
2Parkinsons disease_Homo sapiens_hsa050124.16929226
3Protein export_Homo sapiens_hsa030603.46900728
4Huntingtons disease_Homo sapiens_hsa050163.05698367
5Alzheimers disease_Homo sapiens_hsa050102.94339411
6Proteasome_Homo sapiens_hsa030502.75377287
7RNA polymerase_Homo sapiens_hsa030202.61787406
8Ribosome_Homo sapiens_hsa030102.54046530
9Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.42150577
10Homologous recombination_Homo sapiens_hsa034402.23432810
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.21207974
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.07137619
13Cardiac muscle contraction_Homo sapiens_hsa042601.77214782
14Mismatch repair_Homo sapiens_hsa034301.73703758
15DNA replication_Homo sapiens_hsa030301.68272711
16Non-homologous end-joining_Homo sapiens_hsa034501.66963472
17Spliceosome_Homo sapiens_hsa030401.62472856
18SNARE interactions in vesicular transport_Homo sapiens_hsa041301.60755175
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.48373802
20Pyrimidine metabolism_Homo sapiens_hsa002401.47417204
21Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.42881125
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.41242431
23Nicotine addiction_Homo sapiens_hsa050331.36960275
24Purine metabolism_Homo sapiens_hsa002301.36186308
25Basal transcription factors_Homo sapiens_hsa030221.36022697
26Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.34743331
27RNA degradation_Homo sapiens_hsa030181.34228361
28Base excision repair_Homo sapiens_hsa034101.27938490
29Fatty acid metabolism_Homo sapiens_hsa012121.26586532
30One carbon pool by folate_Homo sapiens_hsa006701.25152246
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.23146044
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.22283974
33Glutathione metabolism_Homo sapiens_hsa004801.18811538
34Butanoate metabolism_Homo sapiens_hsa006501.16234804
35Primary immunodeficiency_Homo sapiens_hsa053401.15463545
36Selenocompound metabolism_Homo sapiens_hsa004501.15253422
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.14312627
38Fatty acid elongation_Homo sapiens_hsa000621.13110132
39Fanconi anemia pathway_Homo sapiens_hsa034601.08169102
40Phototransduction_Homo sapiens_hsa047441.07117089
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.06145886
42Propanoate metabolism_Homo sapiens_hsa006401.04917699
43Folate biosynthesis_Homo sapiens_hsa007901.02219554
44Fatty acid degradation_Homo sapiens_hsa000710.91517402
45Metabolic pathways_Homo sapiens_hsa011000.81588802
46Collecting duct acid secretion_Homo sapiens_hsa049660.76719518
47Renin-angiotensin system_Homo sapiens_hsa046140.75762224
48Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.73535309
49Vibrio cholerae infection_Homo sapiens_hsa051100.72024655
50Glycosaminoglycan degradation_Homo sapiens_hsa005310.71164288
51RNA transport_Homo sapiens_hsa030130.68742061
52Linoleic acid metabolism_Homo sapiens_hsa005910.68452023
53Glycerophospholipid metabolism_Homo sapiens_hsa005640.67939042
54Nucleotide excision repair_Homo sapiens_hsa034200.67281397
55Tryptophan metabolism_Homo sapiens_hsa003800.64614679
56Chemical carcinogenesis_Homo sapiens_hsa052040.63955804
57Ether lipid metabolism_Homo sapiens_hsa005650.63080960
58Lysosome_Homo sapiens_hsa041420.63076571
59Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.61742829
60Morphine addiction_Homo sapiens_hsa050320.59840106
61Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.56594543
62Taste transduction_Homo sapiens_hsa047420.55914185
63Other glycan degradation_Homo sapiens_hsa005110.55575416
64Retinol metabolism_Homo sapiens_hsa008300.54780195
65N-Glycan biosynthesis_Homo sapiens_hsa005100.54756947
66Serotonergic synapse_Homo sapiens_hsa047260.53906363
67Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.53827370
68Caffeine metabolism_Homo sapiens_hsa002320.53610657
69Arachidonic acid metabolism_Homo sapiens_hsa005900.52097107
70Intestinal immune network for IgA production_Homo sapiens_hsa046720.51843648
71Cysteine and methionine metabolism_Homo sapiens_hsa002700.51783210
72Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.48681984
73Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.45770463
74Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.43914693
75Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.43606385
76Transcriptional misregulation in cancer_Homo sapiens_hsa052020.41918453
77Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.41523056
78Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.40990231
79Cell cycle_Homo sapiens_hsa041100.40421755
80Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.39737442
81GABAergic synapse_Homo sapiens_hsa047270.38908049
82Complement and coagulation cascades_Homo sapiens_hsa046100.38830448
83Glutamatergic synapse_Homo sapiens_hsa047240.38773551
84Circadian entrainment_Homo sapiens_hsa047130.36514556
85Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.36139478
86Glycerolipid metabolism_Homo sapiens_hsa005610.35462358
87Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.35009676
88Calcium signaling pathway_Homo sapiens_hsa040200.35000800
89Peroxisome_Homo sapiens_hsa041460.34747085
90Oocyte meiosis_Homo sapiens_hsa041140.34730804
91Nitrogen metabolism_Homo sapiens_hsa009100.34138237
92Cocaine addiction_Homo sapiens_hsa050300.33534117
93Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.32183593
94alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.32159950
95Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.31716767
96Carbon metabolism_Homo sapiens_hsa012000.31272648
97Synaptic vesicle cycle_Homo sapiens_hsa047210.29262626
98Drug metabolism - other enzymes_Homo sapiens_hsa009830.25867036
99Sulfur metabolism_Homo sapiens_hsa009200.24992702
100Rheumatoid arthritis_Homo sapiens_hsa053230.24046121

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