ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	7.36710445
2	energy coupled proton transport, down electrochemical gradient (GO:0015985)	6.39024013
3	ATP synthesis coupled proton transport (GO:0015986)	6.39024013
4	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	5.09708551
5	mitochondrial respiratory chain complex I assembly (GO:0032981)	5.09708551
6	NADH dehydrogenase complex assembly (GO:0010257)	5.09708551
7	platelet dense granule organization (GO:0060155)	5.03665824
8	DNA strand renaturation (GO:0000733)	4.98052766
9	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.80575299
10	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.80232059
11	cullin deneddylation (GO:0010388)	4.52165235
12	blood vessel maturation (GO:0001955)	4.52100910
13	chaperone-mediated protein transport (GO:0072321)	4.51351068
14	protein complex biogenesis (GO:0070271)	4.43904927
15	respiratory electron transport chain (GO:0022904)	4.43840237
16	electron transport chain (GO:0022900)	4.33653295
17	proteasome assembly (GO:0043248)	4.23685682
18	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	4.13371399
19	regulation of mitotic spindle checkpoint (GO:1903504)	4.13371399
20	respiratory chain complex IV assembly (GO:0008535)	3.99360725
21	pyrimidine-containing compound transmembrane transport (GO:0072531)	3.98154138
22	mitochondrial respiratory chain complex assembly (GO:0033108)	3.89931259
23	protein deneddylation (GO:0000338)	3.81947882
24	establishment of integrated proviral latency (GO:0075713)	3.81665151
25	nucleotide transmembrane transport (GO:1901679)	3.77074356
26	viral mRNA export from host cell nucleus (GO:0046784)	3.74519974
27	cytochrome complex assembly (GO:0017004)	3.59555784
28	ATP biosynthetic process (GO:0006754)	3.58533142
29	aldehyde catabolic process (GO:0046185)	3.56681864
30	phagocytosis, recognition (GO:0006910)	3.53500118
31	regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)	3.52704540
32	signal peptide processing (GO:0006465)	3.52133832
33	DNA damage response, detection of DNA damage (GO:0042769)	3.49821246
34	GMP metabolic process (GO:0046037)	3.48097805
35	regulation of T cell chemotaxis (GO:0010819)	3.47516126
36	positive regulation of T cell chemotaxis (GO:0010820)	3.47516126
37	establishment of viral latency (GO:0019043)	3.45115555
38	hydrogen ion transmembrane transport (GO:1902600)	3.41622629
39	protein neddylation (GO:0045116)	3.39920042
40	ER overload response (GO:0006983)	3.38527818
41	multicellular organism reproduction (GO:0032504)	3.37281241
42	female mating behavior (GO:0060180)	3.36619167
43	L-fucose metabolic process (GO:0042354)	3.35632945
44	L-fucose catabolic process (GO:0042355)	3.35632945
45	fucose catabolic process (GO:0019317)	3.35632945
46	inner mitochondrial membrane organization (GO:0007007)	3.34975510
47	organelle membrane fusion (GO:0090174)	3.34733577
48	regulation of RIG-I signaling pathway (GO:0039535)	3.34328199
49	multicellular organismal aging (GO:0010259)	3.33254899
50	oxidative phosphorylation (GO:0006119)	3.32889599
51	adaptation of signaling pathway (GO:0023058)	3.31450944
52	positive regulation of interleukin-8 biosynthetic process (GO:0045416)	3.30928267
53	proton transport (GO:0015992)	3.29818963
54	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.28496292
55	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.27348488
56	protein peptidyl-prolyl isomerization (GO:0000413)	3.25548641
57	hydrogen transport (GO:0006818)	3.23217680
58	macrophage differentiation (GO:0030225)	3.21720439
59	endosome to pigment granule transport (GO:0043485)	3.21119710
60	endosome to melanosome transport (GO:0035646)	3.21119710
61	positive regulation of prostaglandin secretion (GO:0032308)	3.20458628
62	regulation of cilium movement (GO:0003352)	3.20290461
63	acrosome reaction (GO:0007340)	3.20287561
64	rRNA modification (GO:0000154)	3.12461283
65	regulation of nitric-oxide synthase biosynthetic process (GO:0051769)	3.03935690
66	neuromuscular synaptic transmission (GO:0007274)	3.02169933
67	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.97265428
68	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.94734536
69	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.93889158
70	protein localization to mitochondrion (GO:0070585)	2.92051033
71	protein polyglutamylation (GO:0018095)	2.90727079
72	response to pheromone (GO:0019236)	2.90029334
73	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.86241763
74	negative regulation of meiosis (GO:0045835)	2.84623581
75	positive regulation of natural killer cell differentiation (GO:0032825)	2.84238019
76	fusion of sperm to egg plasma membrane (GO:0007342)	2.83510140
77	protein targeting to mitochondrion (GO:0006626)	2.82188226
78	behavioral response to nicotine (GO:0035095)	2.79245340
79	negative regulation of telomere maintenance (GO:0032205)	2.79169325
80	histone mRNA metabolic process (GO:0008334)	2.78132509
81	termination of RNA polymerase III transcription (GO:0006386)	2.77912534
82	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.77912534
83	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	2.76752474
84	peptidyl-proline modification (GO:0018208)	2.76450508
85	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.75750796
86	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.75750796
87	positive regulation of inositol phosphate biosynthetic process (GO:0060732)	2.68759796
88	nucleoside triphosphate biosynthetic process (GO:0009142)	2.67740255
89	fucose metabolic process (GO:0006004)	2.67016398
90	cytokine biosynthetic process (GO:0042089)	2.67005922
91	killing of cells in other organism involved in symbiotic interaction (GO:0051883)	2.66128582
92	disruption of cells of other organism involved in symbiotic interaction (GO:0051818)	2.66128582
93	establishment of protein localization to mitochondrion (GO:0072655)	2.65174794
94	short-chain fatty acid metabolic process (GO:0046459)	2.64368052
95	anterograde synaptic vesicle transport (GO:0048490)	2.62202033
96	regulation of protein kinase A signaling (GO:0010738)	2.61445995
97	activation of adenylate cyclase activity (GO:0007190)	2.60217171
98	purine ribonucleoside monophosphate biosynthetic process (GO:0009168)	2.59994132
99	purine nucleoside monophosphate biosynthetic process (GO:0009127)	2.59994132
100	base-excision repair, AP site formation (GO:0006285)	2.59516941

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	5.53829968
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.60153631
3	EST1_17652178_ChIP-ChIP_JURKAT_Human	4.27275285
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.24629034
5	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.66333582
6	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.57749531
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.42571009
8	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.25174700
9	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.95409811
10	ELK1_19687146_ChIP-ChIP_HELA_Human	2.87338516
11	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.31213057
12	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.24960487
13	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.18405400
14	VDR_23849224_ChIP-Seq_CD4+_Human	2.18034750
15	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.10615633
16	PADI4_21655091_ChIP-ChIP_MCF-7_Human	2.08950372
17	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.05500894
18	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.00938887
19	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.91816637
20	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.82226871
21	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.74087796
22	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.68971225
23	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.64796828
24	ZNF274_21170338_ChIP-Seq_K562_Hela	1.62923811
25	VDR_22108803_ChIP-Seq_LS180_Human	1.60781305
26	GABP_19822575_ChIP-Seq_HepG2_Human	1.57463037
27	P300_19829295_ChIP-Seq_ESCs_Human	1.57390204
28	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.56144755
29	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.52167471
30	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.51021104
31	EWS_26573619_Chip-Seq_HEK293_Human	1.46106951
32	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.44945447
33	FOXP3_21729870_ChIP-Seq_TREG_Human	1.44907425
34	DCP1A_22483619_ChIP-Seq_HELA_Human	1.43091621
35	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.41201106
36	FUS_26573619_Chip-Seq_HEK293_Human	1.35693221
37	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.35606274
38	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.35500847
39	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.31622614
40	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.31471026
41	MYC_18940864_ChIP-ChIP_HL60_Human	1.30071491
42	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.29751301
43	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.27079624
44	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.27071200
45	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.25854684
46	BCAT_22108803_ChIP-Seq_LS180_Human	1.24665338
47	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.21564214
48	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.19234661
49	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.18783919
50	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.17067036
51	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.14303625
52	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.14196053
53	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.10996166
54	GBX2_23144817_ChIP-Seq_PC3_Human	1.10685737
55	XRN2_22483619_ChIP-Seq_HELA_Human	1.10560561
56	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.08244931
57	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.07309041
58	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.06549722
59	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.06011553
60	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.05552089
61	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.05438983
62	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.03702761
63	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.03067895
64	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.02486117
65	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.01060471
66	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.99825186
67	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.99452399
68	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.97625390
69	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.97143636
70	TP53_22573176_ChIP-Seq_HFKS_Human	0.96057128
71	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	0.95247954
72	SOX2_19829295_ChIP-Seq_ESCs_Human	0.93038297
73	NANOG_19829295_ChIP-Seq_ESCs_Human	0.93038297
74	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.92914707
75	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.91545765
76	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.90882924
77	IGF1R_20145208_ChIP-Seq_DFB_Human	0.89682384
78	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.89670656
79	MYC_19829295_ChIP-Seq_ESCs_Human	0.88798306
80	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.86744927
81	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.86613240
82	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.84821888
83	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.84821888
84	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	0.84549163
85	KDM5A_27292631_Chip-Seq_BREAST_Human	0.84397409
86	SOX9_26525672_Chip-Seq_Limbbuds_Mouse	0.83237057
87	TTF2_22483619_ChIP-Seq_HELA_Human	0.83200717
88	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.82001497
89	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.81629464
90	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.81500460
91	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.81491652
92	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.81256824
93	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.81151409
94	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.80424537
95	AR_20517297_ChIP-Seq_VCAP_Human	0.80128802
96	SMAD4_21799915_ChIP-Seq_A2780_Human	0.79722480
97	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.79437508
98	TAF15_26573619_Chip-Seq_HEK293_Human	0.79356804
99	TCF4_23295773_ChIP-Seq_U87_Human	0.79320349
100	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.78737117

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003303_peritoneal_inflammation	4.33832593
2	MP0006054_spinal_hemorrhage	4.31933616
3	MP0000372_irregular_coat_pigmentation	3.79344080
4	MP0004147_increased_porphyrin_level	3.31229083
5	MP0000015_abnormal_ear_pigmentation	2.93343566
6	MP0005174_abnormal_tail_pigmentation	2.63827111
7	MP0000569_abnormal_digit_pigmentation	2.55023660
8	MP0009379_abnormal_foot_pigmentation	2.45946094
9	MP0003806_abnormal_nucleotide_metabolis	2.42362573
10	MP0003283_abnormal_digestive_organ	2.42262667
11	MP0003787_abnormal_imprinting	2.41349261
12	MP0003011_delayed_dark_adaptation	2.40182185
13	MP0001529_abnormal_vocalization	2.24917070
14	MP0005310_abnormal_salivary_gland	2.23575958
15	MP0003950_abnormal_plasma_membrane	2.14701524
16	MP0003315_abnormal_perineum_morphology	2.11821662
17	MP0006276_abnormal_autonomic_nervous	2.03121064
18	MP0005187_abnormal_penis_morphology	2.02453483
19	MP0005075_abnormal_melanosome_morpholog	1.98703700
20	MP0005360_urolithiasis	1.89252097
21	MP0003195_calcinosis	1.81886651
22	MP0000749_muscle_degeneration	1.81871251
23	MP0003186_abnormal_redox_activity	1.78768890
24	MP0004142_abnormal_muscle_tone	1.77577412
25	MP0001984_abnormal_olfaction	1.70165168
26	MP0000383_abnormal_hair_follicle	1.64530502
27	MP0003880_abnormal_central_pattern	1.61934908
28	MP0002095_abnormal_skin_pigmentation	1.61293315
29	MP0004510_myositis	1.59558788
30	MP0004043_abnormal_pH_regulation	1.57863305
31	MP0002751_abnormal_autonomic_nervous	1.55892830
32	MP0003868_abnormal_feces_composition	1.54474432
33	MP0008058_abnormal_DNA_repair	1.54197559
34	MP0005451_abnormal_body_composition	1.52221202
35	MP0002090_abnormal_vision	1.51388878
36	MP0006036_abnormal_mitochondrial_physio	1.49380721
37	MP0005551_abnormal_eye_electrophysiolog	1.48877229
38	MP0010386_abnormal_urinary_bladder	1.47451325
39	MP0005253_abnormal_eye_physiology	1.44567677
40	MP0005408_hypopigmentation	1.42669707
41	MP0009046_muscle_twitch	1.40464480
42	MP0002909_abnormal_adrenal_gland	1.37297972
43	MP0001851_eye_inflammation	1.31805124
44	MP0008877_abnormal_DNA_methylation	1.29895971
45	MP0009745_abnormal_behavioral_response	1.29325596
46	MP0005410_abnormal_fertilization	1.27958652
47	MP0002163_abnormal_gland_morphology	1.26622999
48	MP0001968_abnormal_touch/_nociception	1.25698779
49	MP0004484_altered_response_of	1.25601055
50	MP0006035_abnormal_mitochondrial_morpho	1.24245554
51	MP0003718_maternal_effect	1.12868174
52	MP0002938_white_spotting	1.12514802
53	MP0000358_abnormal_cell_content/	1.10794895
54	MP0002254_reproductive_system_inflammat	1.07316567
55	MP0002272_abnormal_nervous_system	1.06161222
56	MP0005167_abnormal_blood-brain_barrier	1.06111254
57	MP0001879_abnormal_lymphatic_vessel	1.04740704
58	MP0004145_abnormal_muscle_electrophysio	1.01934239
59	MP0003172_abnormal_lysosome_physiology	1.01532135
60	MP0000647_abnormal_sebaceous_gland	0.97084722
61	MP0002876_abnormal_thyroid_physiology	0.95135351
62	MP0008872_abnormal_physiological_respon	0.94903765
63	MP0002108_abnormal_muscle_morphology	0.93106755
64	MP0003633_abnormal_nervous_system	0.89314029
65	MP0004742_abnormal_vestibular_system	0.87677275
66	MP0002184_abnormal_innervation	0.86031691
67	MP0006072_abnormal_retinal_apoptosis	0.80489005
68	MP0005085_abnormal_gallbladder_physiolo	0.78561751
69	MP0004215_abnormal_myocardial_fiber	0.78094508
70	MP0002064_seizures	0.76695232
71	MP0002837_dystrophic_cardiac_calcinosis	0.75237981
72	MP0002269_muscular_atrophy	0.72216311
73	MP0002735_abnormal_chemical_nociception	0.72035475
74	MP0000613_abnormal_salivary_gland	0.71994565
75	MP0008007_abnormal_cellular_replicative	0.71339982
76	MP0002067_abnormal_sensory_capabilities	0.70383800
77	MP0005395_other_phenotype	0.69912200
78	MP0003638_abnormal_response/metabolism_	0.69489607
79	MP0005503_abnormal_tendon_morphology	0.69291192
80	MP0009697_abnormal_copulation	0.68239186
81	MP0003646_muscle_fatigue	0.67971893
82	MP0001756_abnormal_urination	0.66540803
83	MP0008057_abnormal_DNA_replication	0.66176736
84	MP0000538_abnormal_urinary_bladder	0.64502916
85	MP0005266_abnormal_metabolism	0.64355883
86	MP0005165_increased_susceptibility_to	0.64135730
87	MP0005387_immune_system_phenotype	0.63796493
88	MP0001790_abnormal_immune_system	0.63796493
89	MP0001324_abnormal_eye_pigmentation	0.63520214
90	MP0005645_abnormal_hypothalamus_physiol	0.63104065
91	MP0002006_tumorigenesis	0.62776857
92	MP0005171_absent_coat_pigmentation	0.62702073
93	MP0005220_abnormal_exocrine_pancreas	0.61729614
94	MP0002736_abnormal_nociception_after	0.61222894
95	MP0002148_abnormal_hypersensitivity_rea	0.60399461
96	MP0001501_abnormal_sleep_pattern	0.60349409
97	MP0005386_behavior/neurological_phenoty	0.60037521
98	MP0004924_abnormal_behavior	0.60037521
99	MP0001485_abnormal_pinna_reflex	0.59252223
100	MP0010678_abnormal_skin_adnexa	0.54459772

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hepatocellular necrosis (HP:0001404)	5.66789483
2	Acute necrotizing encephalopathy (HP:0006965)	5.54192051
3	Acute encephalopathy (HP:0006846)	5.46486646
4	Mitochondrial inheritance (HP:0001427)	5.32467166
5	Hepatic necrosis (HP:0002605)	4.85145360
6	Increased CSF lactate (HP:0002490)	4.74430845
7	Abnormal mitochondria in muscle tissue (HP:0008316)	4.72335776
8	Progressive macrocephaly (HP:0004481)	4.41839989
9	Congenital stationary night blindness (HP:0007642)	4.11677516
10	Muscle fiber atrophy (HP:0100295)	4.07847017
11	Abnormality of the labia minora (HP:0012880)	4.03730256
12	Type 2 muscle fiber atrophy (HP:0003554)	3.94791098
13	Abnormal number of erythroid precursors (HP:0012131)	3.58788436
14	Respiratory failure (HP:0002878)	3.40392524
15	Cerebral edema (HP:0002181)	3.40284637
16	Abnormal hair whorl (HP:0010721)	3.24588694
17	3-Methylglutaconic aciduria (HP:0003535)	3.20645542
18	Colon cancer (HP:0003003)	3.20377139
19	Limb dystonia (HP:0002451)	3.18585243
20	Abnormality of cells of the erythroid lineage (HP:0012130)	2.87220695
21	Pancreatic cysts (HP:0001737)	2.85880107
22	Medial flaring of the eyebrow (HP:0010747)	2.82915826
23	Constricted visual fields (HP:0001133)	2.80067680
24	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.79639392
25	Emotional lability (HP:0000712)	2.79213502
26	Optic disc pallor (HP:0000543)	2.78232766
27	Increased serum lactate (HP:0002151)	2.77386039
28	Poor suck (HP:0002033)	2.75219180
29	Abnormality of the anterior horn cell (HP:0006802)	2.71384183
30	Degeneration of anterior horn cells (HP:0002398)	2.71384183
31	Aplastic anemia (HP:0001915)	2.64032720
32	Lactic acidosis (HP:0003128)	2.63702860
33	Abnormality of midbrain morphology (HP:0002418)	2.49637975
34	Molar tooth sign on MRI (HP:0002419)	2.49637975
35	Decreased central vision (HP:0007663)	2.48312085
36	Hypothermia (HP:0002045)	2.47927489
37	Parakeratosis (HP:0001036)	2.47539096
38	Pancreatic fibrosis (HP:0100732)	2.46520699
39	Conjunctival telangiectasia (HP:0000524)	2.39243407
40	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.37476943
41	CNS demyelination (HP:0007305)	2.32938116
42	Weak cry (HP:0001612)	2.31981713
43	Congenital primary aphakia (HP:0007707)	2.31524499
44	Lipid accumulation in hepatocytes (HP:0006561)	2.30525203
45	Leukodystrophy (HP:0002415)	2.30323152
46	Gait imbalance (HP:0002141)	2.27228494
47	Agammaglobulinemia (HP:0004432)	2.25946370
48	Neutropenia (HP:0001875)	2.24360016
49	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.21474520
50	Type I transferrin isoform profile (HP:0003642)	2.20432861
51	Lethargy (HP:0001254)	2.19978214
52	Ulnar claw (HP:0001178)	2.18243103
53	Abnormality of the vasculature of the conjunctiva (HP:0008054)	2.17470581
54	Increased hepatocellular lipid droplets (HP:0006565)	2.16278008
55	Methylmalonic aciduria (HP:0012120)	2.16271951
56	Methylmalonic acidemia (HP:0002912)	2.08539489
57	Bile duct proliferation (HP:0001408)	2.07477468
58	Abnormal biliary tract physiology (HP:0012439)	2.07477468
59	Renal Fanconi syndrome (HP:0001994)	2.04155956
60	Delayed CNS myelination (HP:0002188)	2.03236679
61	Fatigable weakness (HP:0003473)	2.02011410
62	Abnormality of the neuromuscular junction (HP:0003398)	2.02011410
63	Tubular atrophy (HP:0000092)	2.01978597
64	Abnormality of the renal medulla (HP:0100957)	2.01943050
65	Abnormality of the renal cortex (HP:0011035)	2.00603984
66	Cone-rod dystrophy (HP:0000548)	1.97260768
67	Exercise intolerance (HP:0003546)	1.95969596
68	Nephronophthisis (HP:0000090)	1.93890058
69	True hermaphroditism (HP:0010459)	1.92295203
70	Increased intramyocellular lipid droplets (HP:0012240)	1.92227250
71	Pheochromocytoma (HP:0002666)	1.90999058
72	Microvesicular hepatic steatosis (HP:0001414)	1.89819241
73	Cerebral hemorrhage (HP:0001342)	1.87065810
74	Vacuolated lymphocytes (HP:0001922)	1.85888846
75	Bilateral microphthalmos (HP:0007633)	1.85842323
76	Dicarboxylic aciduria (HP:0003215)	1.85499731
77	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.85499731
78	Renal cortical cysts (HP:0000803)	1.80114878
79	Abnormality of lateral ventricle (HP:0030047)	1.76935155
80	Keratoconjunctivitis (HP:0001096)	1.76253113
81	Short tibia (HP:0005736)	1.76116636
82	Nephrogenic diabetes insipidus (HP:0009806)	1.75528316
83	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.74982198
84	Sensory axonal neuropathy (HP:0003390)	1.73977657
85	Tubulointerstitial fibrosis (HP:0005576)	1.73526638
86	Gaze-evoked nystagmus (HP:0000640)	1.73422408
87	Nausea (HP:0002018)	1.73102590
88	X-linked dominant inheritance (HP:0001423)	1.71354463
89	Blindness (HP:0000618)	1.70886229
90	Neuroendocrine neoplasm (HP:0100634)	1.70702807
91	Abnormality of urine glucose concentration (HP:0011016)	1.68544660
92	Glycosuria (HP:0003076)	1.68544660
93	Genital tract atresia (HP:0001827)	1.64903498
94	Supernumerary spleens (HP:0009799)	1.64701043
95	Left ventricular hypertrophy (HP:0001712)	1.62593879
96	Abnormal rod and cone electroretinograms (HP:0008323)	1.62295598
97	Abnormality of macular pigmentation (HP:0008002)	1.61433300
98	Increased muscle lipid content (HP:0009058)	1.60690402
99	Attenuation of retinal blood vessels (HP:0007843)	1.59260119
100	Hyperalaninemia (HP:0003348)	1.56877507

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	VRK2	8.73900200
2	EIF2AK3	3.26632077
3	MAP3K12	2.99161022
4	SIK3	2.81040839
5	VRK1	2.75480776
6	BMPR1B	2.62494368
7	FRK	2.56879882
8	TAF1	2.41785359
9	NUAK1	2.40958931
10	EIF2AK1	2.00053756
11	MAP4K2	1.94688092
12	MAPKAPK5	1.76233741
13	MYLK	1.64884725
14	DAPK1	1.62538584
15	GRK7	1.60180699
16	PASK	1.49335486
17	GRK1	1.47021678
18	TSSK6	1.44626552
19	TRIM28	1.36782662
20	MARK1	1.34669965
21	KSR1	1.31630843
22	PLK2	1.21624433
23	CASK	1.21527888
24	MAP3K13	1.20994132
25	TAOK3	1.20279777
26	ADRBK2	1.19002924
27	MST4	1.15269651
28	PRKCG	1.11399195
29	SMG1	1.09834495
30	MAP3K9	1.09643421
31	GRK5	1.07518256
32	STK16	1.06244082
33	TGFBR1	1.04711502
34	CDC7	1.04566644
35	CDK8	1.03048313
36	PLK3	0.99275046
37	WNK3	0.98359650
38	NTRK3	0.96731020
39	PIK3CG	0.91633059
40	IRAK3	0.91272097
41	MAPK4	0.88933668
42	NME1	0.87398047
43	MAP3K3	0.86983596
44	FES	0.84744092
45	MAPKAPK3	0.83764102
46	MAPK13	0.83558149
47	DAPK3	0.81173101
48	PDK2	0.80333490
49	PINK1	0.78133058
50	EPHA4	0.78123853
51	NEK1	0.75826547
52	BUB1	0.74408252
53	DDR2	0.72741980
54	DYRK2	0.72029824
55	PAK3	0.70810609
56	NEK9	0.69803388
57	PRKCE	0.69565563
58	NME2	0.69365943
59	ADRBK1	0.69204949
60	STK39	0.64504793
61	TESK2	0.59264902
62	OXSR1	0.58088696
63	CAMK2A	0.53182830
64	CAMK2G	0.52499139
65	GRK6	0.51673251
66	CSNK1G1	0.49439927
67	CSNK1G3	0.49412587
68	MKNK1	0.43593085
69	MARK3	0.43543298
70	CDK6	0.41381380
71	ARAF	0.41238197
72	DYRK3	0.41205055
73	CLK1	0.40099418
74	TIE1	0.39067576
75	PLK1	0.38875043
76	PAK6	0.37484021
77	PRKCI	0.36315973
78	TRPM7	0.36124889
79	CDK4	0.35941528
80	KSR2	0.35882901
81	KIT	0.35254522
82	MKNK2	0.34289882
83	MAP3K11	0.34175229
84	INSRR	0.33513503
85	EIF2AK2	0.33130755
86	SRPK1	0.33039118
87	TNIK	0.32479834
88	LIMK1	0.29418959
89	GSK3A	0.29381165
90	PBK	0.27213087
91	RPS6KA5	0.27207511
92	CSNK1G2	0.27167527
93	PTK2B	0.26201494
94	KDR	0.26092152
95	CSNK1A1L	0.25229584
96	PRKACB	0.25108599
97	DYRK1A	0.24681088
98	TGFBR2	0.23387131
99	CSNK2A1	0.23311690
100	PRKAA2	0.22905642

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	4.94713684
2	Parkinsons disease_Homo sapiens_hsa05012	4.16929226
3	Protein export_Homo sapiens_hsa03060	3.46900728
4	Huntingtons disease_Homo sapiens_hsa05016	3.05698367
5	Alzheimers disease_Homo sapiens_hsa05010	2.94339411
6	Proteasome_Homo sapiens_hsa03050	2.75377287
7	RNA polymerase_Homo sapiens_hsa03020	2.61787406
8	Ribosome_Homo sapiens_hsa03010	2.54046530
9	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.42150577
10	Homologous recombination_Homo sapiens_hsa03440	2.23432810
11	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.21207974
12	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.07137619
13	Cardiac muscle contraction_Homo sapiens_hsa04260	1.77214782
14	Mismatch repair_Homo sapiens_hsa03430	1.73703758
15	DNA replication_Homo sapiens_hsa03030	1.68272711
16	Non-homologous end-joining_Homo sapiens_hsa03450	1.66963472
17	Spliceosome_Homo sapiens_hsa03040	1.62472856
18	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.60755175
19	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.48373802
20	Pyrimidine metabolism_Homo sapiens_hsa00240	1.47417204
21	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.42881125
22	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.41242431
23	Nicotine addiction_Homo sapiens_hsa05033	1.36960275
24	Purine metabolism_Homo sapiens_hsa00230	1.36186308
25	Basal transcription factors_Homo sapiens_hsa03022	1.36022697
26	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.34743331
27	RNA degradation_Homo sapiens_hsa03018	1.34228361
28	Base excision repair_Homo sapiens_hsa03410	1.27938490
29	Fatty acid metabolism_Homo sapiens_hsa01212	1.26586532
30	One carbon pool by folate_Homo sapiens_hsa00670	1.25152246
31	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.23146044
32	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.22283974
33	Glutathione metabolism_Homo sapiens_hsa00480	1.18811538
34	Butanoate metabolism_Homo sapiens_hsa00650	1.16234804
35	Primary immunodeficiency_Homo sapiens_hsa05340	1.15463545
36	Selenocompound metabolism_Homo sapiens_hsa00450	1.15253422
37	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.14312627
38	Fatty acid elongation_Homo sapiens_hsa00062	1.13110132
39	Fanconi anemia pathway_Homo sapiens_hsa03460	1.08169102
40	Phototransduction_Homo sapiens_hsa04744	1.07117089
41	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.06145886
42	Propanoate metabolism_Homo sapiens_hsa00640	1.04917699
43	Folate biosynthesis_Homo sapiens_hsa00790	1.02219554
44	Fatty acid degradation_Homo sapiens_hsa00071	0.91517402
45	Metabolic pathways_Homo sapiens_hsa01100	0.81588802
46	Collecting duct acid secretion_Homo sapiens_hsa04966	0.76719518
47	Renin-angiotensin system_Homo sapiens_hsa04614	0.75762224
48	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.73535309
49	Vibrio cholerae infection_Homo sapiens_hsa05110	0.72024655
50	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.71164288
51	RNA transport_Homo sapiens_hsa03013	0.68742061
52	Linoleic acid metabolism_Homo sapiens_hsa00591	0.68452023
53	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.67939042
54	Nucleotide excision repair_Homo sapiens_hsa03420	0.67281397
55	Tryptophan metabolism_Homo sapiens_hsa00380	0.64614679
56	Chemical carcinogenesis_Homo sapiens_hsa05204	0.63955804
57	Ether lipid metabolism_Homo sapiens_hsa00565	0.63080960
58	Lysosome_Homo sapiens_hsa04142	0.63076571
59	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.61742829
60	Morphine addiction_Homo sapiens_hsa05032	0.59840106
61	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.56594543
62	Taste transduction_Homo sapiens_hsa04742	0.55914185
63	Other glycan degradation_Homo sapiens_hsa00511	0.55575416
64	Retinol metabolism_Homo sapiens_hsa00830	0.54780195
65	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.54756947
66	Serotonergic synapse_Homo sapiens_hsa04726	0.53906363
67	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.53827370
68	Caffeine metabolism_Homo sapiens_hsa00232	0.53610657
69	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.52097107
70	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.51843648
71	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.51783210
72	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.48681984
73	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.45770463
74	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.43914693
75	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.43606385
76	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.41918453
77	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.41523056
78	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.40990231
79	Cell cycle_Homo sapiens_hsa04110	0.40421755
80	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.39737442
81	GABAergic synapse_Homo sapiens_hsa04727	0.38908049
82	Complement and coagulation cascades_Homo sapiens_hsa04610	0.38830448
83	Glutamatergic synapse_Homo sapiens_hsa04724	0.38773551
84	Circadian entrainment_Homo sapiens_hsa04713	0.36514556
85	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.36139478
86	Glycerolipid metabolism_Homo sapiens_hsa00561	0.35462358
87	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.35009676
88	Calcium signaling pathway_Homo sapiens_hsa04020	0.35000800
89	Peroxisome_Homo sapiens_hsa04146	0.34747085
90	Oocyte meiosis_Homo sapiens_hsa04114	0.34730804
91	Nitrogen metabolism_Homo sapiens_hsa00910	0.34138237
92	Cocaine addiction_Homo sapiens_hsa05030	0.33534117
93	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.32183593
94	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.32159950
95	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.31716767
96	Carbon metabolism_Homo sapiens_hsa01200	0.31272648
97	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.29262626
98	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.25867036
99	Sulfur metabolism_Homo sapiens_hsa00920	0.24992702
100	Rheumatoid arthritis_Homo sapiens_hsa05323	0.24046121

GAPDHP33

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »