ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	eosinophil migration (GO:0072677)	9.73335406
2	regulation of sister chromatid cohesion (GO:0007063)	9.66226279
3	regulation of mononuclear cell migration (GO:0071675)	9.57353569
4	negative regulation of peptidyl-threonine phosphorylation (GO:0010801)	9.53891311
5	branch elongation of an epithelium (GO:0060602)	8.52419921
6	negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)	8.04591913
7	positive regulation of chromosome segregation (GO:0051984)	7.96488813
8	ribosomal small subunit assembly (GO:0000028)	7.77273536
9	L-fucose catabolic process (GO:0042355)	7.75946616
10	fucose catabolic process (GO:0019317)	7.75946616
11	L-fucose metabolic process (GO:0042354)	7.75946616
12	negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)	7.73654979
13	vesicle fusion (GO:0006906)	7.69111648
14	peptidyl-lysine dimethylation (GO:0018027)	7.39622632
15	coenzyme A biosynthetic process (GO:0015937)	7.11775319
16	autophagic vacuole fusion (GO:0000046)	6.92483130
17	macrophage chemotaxis (GO:0048246)	6.83481310
18	organ growth (GO:0035265)	6.58207254
19	localization within membrane (GO:0051668)	6.51977958
20	axis elongation (GO:0003401)	6.37644085
21	regulation of nitric-oxide synthase biosynthetic process (GO:0051769)	5.98248932
22	regulation of beta-amyloid formation (GO:1902003)	5.93381134
23	positive regulation of calcium ion import (GO:0090280)	5.92674995
24	establishment of mitotic spindle orientation (GO:0000132)	5.92092798
25	negative regulation of GTPase activity (GO:0034260)	5.76760500
26	negative regulation of GTP catabolic process (GO:0033125)	5.76760500
27	regulation of T cell receptor signaling pathway (GO:0050856)	5.75611603
28	monocyte chemotaxis (GO:0002548)	5.72141491
29	protein import into peroxisome matrix (GO:0016558)	5.42824654
30	organelle membrane fusion (GO:0090174)	5.42404356
31	double-strand break repair via nonhomologous end joining (GO:0006303)	5.23998208
32	non-recombinational repair (GO:0000726)	5.23998208
33	establishment of mitotic spindle localization (GO:0040001)	5.22784271
34	3-UTR-mediated mRNA stabilization (GO:0070935)	5.17330832
35	establishment of spindle orientation (GO:0051294)	5.14317594
36	acrosome assembly (GO:0001675)	4.90888732
37	negative regulation of circadian rhythm (GO:0042754)	4.90633386
38	histone H3-K9 methylation (GO:0051567)	4.82870953
39	regulation of amyloid precursor protein catabolic process (GO:1902991)	4.79424042
40	positive chemotaxis (GO:0050918)	4.74106730
41	detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)	4.69902545
42	regulation of autophagic vacuole assembly (GO:2000785)	4.67552727
43	seminiferous tubule development (GO:0072520)	4.66251929
44	pantothenate metabolic process (GO:0015939)	4.61936261
45	organelle fusion (GO:0048284)	4.60373777
46	positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)	4.55462946
47	oxidative demethylation (GO:0070989)	4.54309485
48	purine nucleoside bisphosphate biosynthetic process (GO:0034033)	4.46525847
49	ribonucleoside bisphosphate biosynthetic process (GO:0034030)	4.46525847
50	nucleoside bisphosphate biosynthetic process (GO:0033866)	4.46525847
51	regulation of stem cell maintenance (GO:2000036)	4.43320800
52	fucose metabolic process (GO:0006004)	4.37522822
53	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	4.32609951
54	membrane budding (GO:0006900)	4.29003909
55	protein targeting to lysosome (GO:0006622)	4.13143589
56	establishment of protein localization to vacuole (GO:0072666)	4.13143589
57	protein targeting to vacuole (GO:0006623)	4.13143589
58	coenzyme A metabolic process (GO:0015936)	4.11407339
59	regulation of antigen receptor-mediated signaling pathway (GO:0050854)	4.09314842
60	fucosylation (GO:0036065)	4.06972809
61	regulation of fibroblast growth factor receptor signaling pathway (GO:0040036)	4.02943695
62	histone H3-K9 modification (GO:0061647)	4.01265746
63	detection of chemical stimulus involved in sensory perception of taste (GO:0050912)	4.01261218
64	negative regulation of purine nucleotide catabolic process (GO:0033122)	4.00097064
65	negative regulation of macroautophagy (GO:0016242)	3.90021615
66	regulation of vacuole organization (GO:0044088)	3.89323761
67	regulation of cellular amide metabolic process (GO:0034248)	3.84082969
68	negative regulation of nucleotide catabolic process (GO:0030812)	3.83446752
69	single-organism membrane fusion (GO:0044801)	3.80233797
70	establishment of spindle localization (GO:0051293)	3.79393714
71	regulation of mammary gland epithelial cell proliferation (GO:0033599)	3.78987066
72	negative regulation of nucleoside metabolic process (GO:0045978)	3.63051550
73	vesicle targeting (GO:0006903)	3.58975632
74	regulation of peptidyl-threonine phosphorylation (GO:0010799)	3.58820930
75	protein localization to peroxisome (GO:0072662)	3.56385237
76	protein targeting to peroxisome (GO:0006625)	3.56385237
77	establishment of protein localization to peroxisome (GO:0072663)	3.56385237
78	DNA integration (GO:0015074)	3.55795804
79	regulation of calcium ion import (GO:0090279)	3.55750953
80	sodium-independent organic anion transport (GO:0043252)	3.48520319
81	imidazole-containing compound metabolic process (GO:0052803)	3.46255514
82	ER to Golgi vesicle-mediated transport (GO:0006888)	3.42626993
83	negative regulation of dendrite morphogenesis (GO:0050774)	3.39295778
84	labyrinthine layer development (GO:0060711)	3.34059191
85	peroxisomal transport (GO:0043574)	3.32348237
86	telomere maintenance via recombination (GO:0000722)	3.30019318
87	regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:2	3.29480237
88	Golgi transport vesicle coating (GO:0048200)	3.28086379
89	COPI coating of Golgi vesicle (GO:0048205)	3.28086379
90	protein localization to vacuole (GO:0072665)	3.27886471
91	protein localization to lysosome (GO:0061462)	3.27886471
92	peptidyl-lysine trimethylation (GO:0018023)	3.23391528
93	prenylation (GO:0097354)	12.7078589
94	protein prenylation (GO:0018342)	12.7078589
95	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	12.3915894
96	positive regulation of mitotic sister chromatid separation (GO:1901970)	12.3915894
97	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	12.3915894
98	negative regulation of Ras GTPase activity (GO:0034261)	12.2202608
99	eosinophil chemotaxis (GO:0048245)	10.7536927
100	negative regulation of T cell receptor signaling pathway (GO:0050860)	10.3044694

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	9.04973218
2	VDR_22108803_ChIP-Seq_LS180_Human	6.15052831
3	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	4.71650899
4	NOTCH1_21737748_ChIP-Seq_TLL_Human	4.52015024
5	AR_21572438_ChIP-Seq_LNCaP_Human	3.47661806
6	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.92948942
7	SRY_22984422_ChIP-ChIP_TESTIS_Rat	2.70210727
8	ZIC3_20872845_ChIP-ChIP_MESCs_Mouse	2.66157933
9	ZNF263_19887448_ChIP-Seq_K562_Human	2.60905828
10	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.37675250
11	YY1_21170310_ChIP-Seq_MESCs_Mouse	2.37547321
12	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.31245179
13	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	2.29306888
14	GATA1_22025678_ChIP-Seq_K562_Human	11.6349316
15	RXR_22108803_ChIP-Seq_LS180_Human	1.94767399
16	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.94068949
17	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.89636796
18	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.85219233
19	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.85219233
20	BCAT_22108803_ChIP-Seq_LS180_Human	1.59313909
21	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.57211063
22	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.52128701
23	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.45890458
24	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.44828170
25	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.43684395
26	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.43684395
27	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.43684395
28	TAF15_26573619_Chip-Seq_HEK293_Human	1.38337730
29	GBX2_23144817_ChIP-Seq_PC3_Human	1.33246723
30	TP53_16413492_ChIP-PET_HCT116_Human	1.29701883
31	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.28154005
32	IRF1_19129219_ChIP-ChIP_H3396_Human	1.24008263
33	GATA3_26560356_Chip-Seq_TH1_Human	1.23572995
34	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.20039397
35	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.17069138
36	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.16062764
37	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.13679388
38	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.13381858
39	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.12756087
40	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.11519722
41	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	1.07489622
42	RUNX_20019798_ChIP-Seq_JUKART_Human	1.03540656
43	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.03328066
44	CTCF_21964334_Chip-Seq_Bcells_Human	0.98153961
45	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.95863037
46	WDR5_24793694_ChIP-Seq_LNCAP_Human	0.94840057
47	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.94006132
48	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.91328945
49	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	0.90833331
50	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.90535055
51	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	0.88210279
52	HTT_18923047_ChIP-ChIP_STHdh_Human	0.87155690
53	GATA1_19941826_ChIP-Seq_K562_Human	0.84277497
54	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.84120620
55	TBX3_20139965_ChIP-Seq_ESCs_Mouse	0.82175598
56	TBX3_20139965_ChIP-Seq_MESCs_Mouse	0.81906731
57	CDX2_20551321_ChIP-Seq_CACO-2_Human	0.81846769
58	NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human	0.80578988
59	SOX3_22085726_ChIP-Seq_MUSCLE_Mouse	0.78344555
60	EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	0.77482922
61	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	0.75661104
62	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	0.73799884
63	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.71697378
64	RING1B_27294783_Chip-Seq_NPCs_Mouse	0.69270054
65	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.67836508
66	CTNNB1_20460455_ChIP-Seq_HCT116_Human	0.67616418
67	TP53_22573176_ChIP-Seq_HFKS_Human	0.65798261
68	ETS1_20019798_ChIP-Seq_JURKAT_Human	0.64698215
69	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.64251823
70	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.62258617
71	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.61640864
72	SMC1_22415368_ChIP-Seq_MEFs_Mouse	0.61635673
73	ZNF274_21170338_ChIP-Seq_K562_Hela	0.60741852
74	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.60738591
75	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.59190299
76	STAT1_20625510_ChIP-Seq_HELA_Human	0.58748692
77	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.58242220
78	NR3C1_23031785_ChIP-Seq_PC12_Mouse	0.58208661
79	GABP_17652178_ChIP-ChIP_JURKAT_Human	0.58146970
80	TRIM28_19339689_ChIP-ChIP_MESCs_Mouse	0.58048221
81	EOMES_20176728_ChIP-ChIP_TSCs_Mouse	0.58011925
82	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.57207186
83	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.56685144
84	TCF4_22108803_ChIP-Seq_LS180_Human	0.56024092
85	LUZP1_20508642_ChIP-Seq_ESCs_Mouse	0.55988930
86	GATA3_21867929_ChIP-Seq_TH1_Mouse	0.54539565
87	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.54257769
88	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.53283369
89	ERG_20517297_ChIP-Seq_VCAP_Human	0.53173194
90	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.52980430
91	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.52637028
92	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.52366759
93	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	0.52158863
94	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.51432201
95	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	0.51355730
96	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.50951807
97	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.50951807
98	MYC_18555785_ChIP-Seq_MESCs_Mouse	0.50873190
99	NANOG_20526341_ChIP-Seq_ESCs_Human	0.50413346
100	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.50201621

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003303_peritoneal_inflammation	9.97994437
2	MP0006082_CNS_inflammation	5.48455226
3	MP0000467_abnormal_esophagus_morphology	3.33206971
4	MP0001664_abnormal_digestion	3.23751680
5	MP0001663_abnormal_digestive_system	3.14774787
6	MP0001919_abnormal_reproductive_system	2.77723736
7	MP0002751_abnormal_autonomic_nervous	2.56916003
8	MP0000383_abnormal_hair_follicle	2.48929299
9	MP0003115_abnormal_respiratory_system	2.47548205
10	MP0005381_digestive/alimentary_phenotyp	2.44629901
11	MP0000566_synostosis	13.0429020
12	MP0005166_decreased_susceptibility_to	1.86259665
13	MP0002876_abnormal_thyroid_physiology	1.77574419
14	MP0010678_abnormal_skin_adnexa	1.72505618
15	MP0005389_reproductive_system_phenotype	1.62337846
16	MP0001915_intracranial_hemorrhage	1.60638942
17	MP0000534_abnormal_ureter_morphology	1.60414995
18	MP0003453_abnormal_keratinocyte_physiol	1.60131186
19	MP0003937_abnormal_limbs/digits/tail_de	1.55625761
20	MP0005397_hematopoietic_system_phenotyp	1.43848665
21	MP0001545_abnormal_hematopoietic_system	1.43848665
22	MP0005076_abnormal_cell_differentiation	1.43460869
23	MP0000428_abnormal_craniofacial_morphol	1.40512132
24	MP0005501_abnormal_skin_physiology	1.12991493
25	MP0000858_altered_metastatic_potential	1.10567240
26	MP0001286_abnormal_eye_development	1.09782509
27	MP0003763_abnormal_thymus_physiology	1.06152829
28	MP0000490_abnormal_crypts_of	1.05226955
29	MP0001293_anophthalmia	1.02710008
30	MP0002019_abnormal_tumor_incidence	0.95500067
31	MP0001764_abnormal_homeostasis	0.88871736
32	MP0003329_amyloid_beta_deposits	0.85305818
33	MP0002109_abnormal_limb_morphology	0.84420454
34	MP0000470_abnormal_stomach_morphology	0.84413757
35	MP0003942_abnormal_urinary_system	0.81055476
36	MP0002115_abnormal_skeleton_extremities	0.78642811
37	MP0005197_abnormal_uvea_morphology	0.77579375
38	MP0010155_abnormal_intestine_physiology	0.76933287
39	MP0000026_abnormal_inner_ear	0.76644798
40	MP0001963_abnormal_hearing_physiology	0.72684497
41	MP0000358_abnormal_cell_content/	0.72135903
42	MP0009763_increased_sensitivity_to	0.68974411
43	MP0005508_abnormal_skeleton_morphology	0.65641761
44	MP0000477_abnormal_intestine_morphology	0.64053546
45	MP0002405_respiratory_system_inflammati	0.60326686
46	MP0000432_abnormal_head_morphology	0.57757014
47	MP0005023_abnormal_wound_healing	0.55918984
48	MP0002184_abnormal_innervation	0.54818339
49	MP0000604_amyloidosis	0.54712227
50	MP0009672_abnormal_birth_weight	0.52174952
51	MP0001175_abnormal_lung_morphology	0.51810950
52	MP0000681_abnormal_thyroid_gland	0.50343950
53	MP0002113_abnormal_skeleton_development	0.48459283
54	MP0003935_abnormal_craniofacial_develop	0.48371947
55	MP0002210_abnormal_sex_determination	0.47467101
56	MP0002168_other_aberrant_phenotype	0.46867358
57	MP0005645_abnormal_hypothalamus_physiol	0.46785382
58	MP0003448_altered_tumor_morphology	0.45711049
59	MP0000377_abnormal_hair_follicle	0.44645767
60	MP0005025_abnormal_response_to	0.43893512
61	MP0005253_abnormal_eye_physiology	0.41804410
62	MP0002822_catalepsy	0.40260897
63	MP0005423_abnormal_somatic_nervous	0.40066467
64	MP0003638_abnormal_response/metabolism_	0.38747741
65	MP0000627_abnormal_mammary_gland	0.36951503
66	MP0000163_abnormal_cartilage_morphology	0.36380946
67	MP0001986_abnormal_taste_sensitivity	0.32944391
68	MP0002697_abnormal_eye_size	0.32783381
69	MP0005391_vision/eye_phenotype	0.32773787
70	MP0003936_abnormal_reproductive_system	0.32274690
71	MP0002452_abnormal_antigen_presenting	0.32174203
72	MP0003880_abnormal_central_pattern	0.31972711
73	MP0002752_abnormal_somatic_nervous	0.31765133
74	MP0008004_abnormal_stomach_pH	0.29542482
75	MP0002136_abnormal_kidney_physiology	0.29482453
76	MP0005000_abnormal_immune_tolerance	0.29260023
77	MP0005390_skeleton_phenotype	0.28310344
78	MP0003195_calcinosis	0.27024947
79	MP0002735_abnormal_chemical_nociception	0.26753438
80	MP0001800_abnormal_humoral_immune	0.26178649
81	MP0010771_integument_phenotype	0.25987720
82	MP0008058_abnormal_DNA_repair	0.24416036
83	MP0003646_muscle_fatigue	0.24008283
84	MP0002736_abnormal_nociception_after	0.20184477
85	MP0002420_abnormal_adaptive_immunity	0.19879048
86	MP0004197_abnormal_fetal_growth/weight/	0.19267533
87	MP0000350_abnormal_cell_proliferation	0.19192971
88	MP0001819_abnormal_immune_cell	0.19087485
89	MP0005503_abnormal_tendon_morphology	0.18002440
90	MP0009931_abnormal_skin_appearance	0.17891846
91	MP0000049_abnormal_middle_ear	0.17032429
92	MP0005275_abnormal_skin_tensile	0.16873867
93	MP0005332_abnormal_amino_acid	0.16798369
94	MP0002638_abnormal_pupillary_reflex	0.16078667
95	MP0002419_abnormal_innate_immunity	0.15943352
96	MP0010386_abnormal_urinary_bladder	0.15942988
97	MP0005671_abnormal_response_to	0.15899678
98	MP0003283_abnormal_digestive_organ	0.15462683
99	MP0000343_altered_response_to	0.15460841
100	MP0002139_abnormal_hepatobiliary_system	0.15442693

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Duplicated collecting system (HP:0000081)	9.32672066
2	Long foot (HP:0001833)	9.10659879
3	Abnormality of the renal collecting system (HP:0004742)	8.40649899
4	Large for gestational age (HP:0001520)	7.13686601
5	Acute lymphatic leukemia (HP:0006721)	7.09001387
6	Progressive muscle weakness (HP:0003323)	6.98011128
7	Adactyly (HP:0009776)	6.66150429
8	Abnormality of fatty-acid metabolism (HP:0004359)	6.36863095
9	Hypoplastic pelvis (HP:0008839)	6.14312000
10	Dry hair (HP:0011359)	5.74547858
11	Pulmonary artery stenosis (HP:0004415)	5.65807712
12	Autoamputation (HP:0001218)	5.63791677
13	Ureteral stenosis (HP:0000071)	5.53249766
14	Brushfield spots (HP:0001088)	5.24260346
15	Steatorrhea (HP:0002570)	5.19461767
16	Menstrual irregularities (HP:0000858)	5.15923083
17	Ureteral obstruction (HP:0006000)	5.12851222
18	Ureteral duplication (HP:0000073)	5.11152785
19	Hypoplastic nipples (HP:0002557)	4.83802115
20	Reduced subcutaneous adipose tissue (HP:0003758)	4.55392565
21	Abnormal auditory evoked potentials (HP:0006958)	4.48894487
22	Sudden death (HP:0001699)	4.47994078
23	Abnormal ventriculo-arterial connection (HP:0011563)	4.20457634
24	Transposition of the great arteries (HP:0001669)	4.20457634
25	Abnormal connection of the cardiac segments (HP:0011545)	4.20457634
26	Fat malabsorption (HP:0002630)	4.01927900
27	Decreased lacrimation (HP:0000633)	3.96667018
28	Increased number of teeth (HP:0011069)	3.92144793
29	Severe muscular hypotonia (HP:0006829)	3.91059167
30	Palmoplantar hyperkeratosis (HP:0000972)	3.83307307
31	Anhidrosis (HP:0000970)	3.82980619
32	Broad-based gait (HP:0002136)	3.78301917
33	Palmar hyperkeratosis (HP:0010765)	3.61633680
34	Abnormality of vision evoked potentials (HP:0000649)	3.40040264
35	Polyneuropathy (HP:0001271)	3.31445217
36	Rhabdomyolysis (HP:0003201)	3.30063512
37	Generalized amyotrophy (HP:0003700)	3.26160929
38	Wide intermamillary distance (HP:0006610)	3.20632546
39	Broad nasal tip (HP:0000455)	3.19486081
40	Myoglobinuria (HP:0002913)	3.17012074
41	Large hands (HP:0001176)	3.13998805
42	Plantar hyperkeratosis (HP:0007556)	3.11030931
43	Decreased muscle mass (HP:0003199)	3.08799510
44	Polymicrogyria (HP:0002126)	3.01284785
45	Clubbing of toes (HP:0100760)	2.95821249
46	Epiphyseal stippling (HP:0010655)	2.67334005
47	Flat face (HP:0012368)	2.54782335
48	Hypoplastic iliac wings (HP:0002866)	2.53158373
49	Chorioretinal coloboma (HP:0000567)	2.51495025
50	Steppage gait (HP:0003376)	2.44775140
51	Basal ganglia calcification (HP:0002135)	2.43248949
52	Purpura (HP:0000979)	2.41821626
53	Overfolded helix (HP:0000396)	2.41814679
54	Widely spaced teeth (HP:0000687)	2.35218864
55	Thickened calvaria (HP:0002684)	2.29440366
56	Posterior embryotoxon (HP:0000627)	2.28021858
57	Abnormality of the line of Schwalbe (HP:0008048)	2.20936077
58	Foot dorsiflexor weakness (HP:0009027)	2.18328556
59	Anxiety (HP:0000739)	2.18001531
60	Abnormally folded helix (HP:0008544)	2.17999049
61	Absent toe (HP:0010760)	2.17299183
62	Female pseudohermaphroditism (HP:0010458)	2.11648120
63	Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)	2.08422471
64	External ear malformation (HP:0008572)	2.03335750
65	Aplasia/Hypoplasia of the nipples (HP:0006709)	2.02497402
66	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	12.0734098
67	Thickened nuchal skin fold (HP:0000474)	1.99692481
68	Abnormality of the foot musculature (HP:0001436)	1.98464569
69	Hammertoe (HP:0001765)	1.95588309
70	Prenatal maternal abnormality (HP:0002686)	1.94369426
71	Primary adrenal insufficiency (HP:0008207)	1.90876701
72	Abnormal epiphyseal ossification (HP:0010656)	1.89356089
73	Generalized muscle weakness (HP:0003324)	1.84854099
74	Gangrene (HP:0100758)	1.82965406
75	Stereotypic behavior (HP:0000733)	1.80921140
76	Abnormality of the epiphyses of the hand (HP:0005924)	1.80086790
77	Arterial thrombosis (HP:0004420)	1.78197730
78	Spastic tetraplegia (HP:0002510)	1.76012491
79	Arthrogryposis multiplex congenita (HP:0002804)	1.72414158
80	Congenital onset (HP:0003577)	1.70970937
81	Depressed nasal ridge (HP:0000457)	1.67654109
82	Abnormality involving the epiphyses of the upper limbs (HP:0003839)	1.67505446
83	Decreased motor nerve conduction velocity (HP:0003431)	1.64334072
84	Nail dystrophy (HP:0008404)	1.57715849
85	Underdeveloped supraorbital ridges (HP:0009891)	1.56294203
86	Aplasia/Hypoplasia involving the pelvis (HP:0009103)	1.56151601
87	Lactic acidosis (HP:0003128)	1.55727097
88	Short philtrum (HP:0000322)	1.55033913
89	Decreased number of peripheral myelinated nerve fibers (HP:0003380)	1.54395539
90	Scrotal hypoplasia (HP:0000046)	1.52941276
91	Hyperammonemia (HP:0001987)	1.50905303
92	Brachycephaly (HP:0000248)	1.50340513
93	Respiratory insufficiency due to muscle weakness (HP:0002747)	1.48267856
94	Hypoplastic ilia (HP:0000946)	1.46496736
95	Pulmonary embolism (HP:0002204)	1.39487951
96	Abnormality of primary teeth (HP:0006481)	1.39335501
97	Webbed neck (HP:0000465)	1.36295471
98	Opacification of the corneal stroma (HP:0007759)	1.34703904
99	Freckling (HP:0001480)	1.33370570
100	Metabolic acidosis (HP:0001942)	1.27132672

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MKNK1	6.81550839
2	TAOK2	5.59650995
3	TAOK1	5.52979770
4	MAP3K3	4.13601277
5	MAP3K11	4.05809118
6	MAP2K3	4.00631342
7	JAK3	2.46660932
8	MKNK2	11.5286131
9	ABL2	1.87707337
10	DYRK1A	1.76007058
11	MAP3K5	1.34293077
12	MAP3K1	1.00988541
13	SRPK1	0.95301597
14	CHEK2	0.78171402
15	MAP3K8	0.66594501
16	PRKCQ	0.47626986
17	KDR	0.24569880
18	TXK	0.22945538
19	CSNK1A1	0.18700281
20	MAP3K10	0.16973045
21	ABL1	0.16930570
22	IGF1R	0.15595290
23	INSRR	0.14608455
24	OBSCN	0.14055716
25	MUSK	0.12782230
26	GRK1	0.12545101
27	MAP4K2	0.08700810
28	PRKCD	0.07621001
29	GRK7	0.07413204
30	WNK3	0.05551985
31	CSNK2A2	0.05268453
32	TIE1	0.04906895
33	ADRBK2	0.04727530
34	MAPK15	0.04576659
35	PINK1	0.04224011
36	CSNK2A1	0.01828465
37	PRKCA	0.00939476
38	PIK3CG	0.00442999
39	CSNK1E	0.00438691
40	AURKA	0.00271431
41	PRKCE	-0.1210686
42	TGFBR2	-0.1200535
43	PIK3CA	-0.1191349
44	MARK1	-0.1177029
45	ZAK	-0.1162422
46	CAMK2B	-0.1111318
47	EGFR	-0.1108319
48	PRKACG	-0.1104602
49	PRKG1	-0.1102734
50	ROCK1	-0.1082750
51	STK39	-0.1078711
52	MAPK14	-0.1077799
53	MAPK4	-0.1060383
54	TNK2	-0.1041454
55	CAMK2G	-0.1011098
56	CDK2	-0.1010194
57	MAPKAPK5	-0.0999234
58	PRKCG	-0.0989375
59	WEE1	-0.0982772
60	MAP2K6	-0.0973854
61	PIM1	-0.0945120
62	MAP4K1	-0.0926501
63	PKN1	-0.0923726
64	WNK4	-0.0910617
65	CAMK2A	-0.0875911
66	DAPK3	-0.0875015
67	LYN	-0.0823282
68	SYK	-0.0804042
69	NEK9	-0.0797619
70	PIM2	-0.0786391
71	BTK	-0.0782127
72	OXSR1	-0.0762499
73	EPHA2	-0.0748957
74	ERBB2	-0.0726635
75	VRK2	-0.0712866
76	NTRK2	-0.0701319
77	VRK1	-0.0667671
78	ADRBK1	-0.0633596
79	TLK1	-0.0609541
80	BLK	-0.0593226
81	DDR2	-0.0590916
82	FRK	-0.0585720
83	PHKG1	-0.0548971
84	PHKG2	-0.0548971
85	LMTK2	-0.0490713
86	ITK	-0.0469519
87	MST1R	-0.0455961
88	TTN	-0.0423622
89	PLK4	-0.0418718
90	EPHA4	-0.0361392
91	GRK6	-0.0347717
92	GRK5	-0.0297027
93	TEC	-0.0295356
94	PRKACA	-0.0236229
95	MYLK	-0.0200024
96	KIT	-0.0186681
97	SRC	-0.0178995
98	PRKCB	-0.0166716
99	MATK	-0.0146687
100	ERBB4	-0.0003731

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	8.78908178
2	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	7.15438340
3	Taste transduction_Homo sapiens_hsa04742	3.11797985
4	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.02158470
5	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	2.91347061
6	RNA polymerase_Homo sapiens_hsa03020	2.78187012
7	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.67403029
8	Fatty acid elongation_Homo sapiens_hsa00062	2.64761679
9	Butanoate metabolism_Homo sapiens_hsa00650	2.49363137
10	Lysine degradation_Homo sapiens_hsa00310	2.47988485
11	beta-Alanine metabolism_Homo sapiens_hsa00410	1.94612105
12	Proteasome_Homo sapiens_hsa03050	1.92909193
13	Amoebiasis_Homo sapiens_hsa05146	1.84962181
14	One carbon pool by folate_Homo sapiens_hsa00670	1.77344721
15	Glycerolipid metabolism_Homo sapiens_hsa00561	1.77228151
16	Tryptophan metabolism_Homo sapiens_hsa00380	1.63777931
17	Propanoate metabolism_Homo sapiens_hsa00640	1.58150882
18	Viral myocarditis_Homo sapiens_hsa05416	1.17092135
19	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	1.12202322
20	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.12010536
21	Peroxisome_Homo sapiens_hsa04146	1.08592041
22	Fatty acid degradation_Homo sapiens_hsa00071	1.01791694
23	Complement and coagulation cascades_Homo sapiens_hsa04610	1.00546753
24	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.90194741
25	Fatty acid metabolism_Homo sapiens_hsa01212	0.79802717
26	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.72184554
27	Malaria_Homo sapiens_hsa05144	0.71213013
28	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.64269058
29	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.64113868
30	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.64059291
31	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.63320298
32	Caffeine metabolism_Homo sapiens_hsa00232	0.63017817
33	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.62306739
34	Salmonella infection_Homo sapiens_hsa05132	0.61355199
35	MicroRNAs in cancer_Homo sapiens_hsa05206	0.61184455
36	Olfactory transduction_Homo sapiens_hsa04740	0.59918826
37	AMPK signaling pathway_Homo sapiens_hsa04152	0.59141754
38	Retinol metabolism_Homo sapiens_hsa00830	0.57928325
39	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.57898515
40	Nicotine addiction_Homo sapiens_hsa05033	0.57466851
41	Asthma_Homo sapiens_hsa05310	0.57107748
42	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.56466893
43	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.55764557
44	Cholinergic synapse_Homo sapiens_hsa04725	0.53541514
45	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.53231097
46	Graft-versus-host disease_Homo sapiens_hsa05332	0.52899390
47	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.52072481
48	Phototransduction_Homo sapiens_hsa04744	0.49993281
49	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.49091501
50	Allograft rejection_Homo sapiens_hsa05330	0.49012360
51	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.47449076
52	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.46452484
53	Primary immunodeficiency_Homo sapiens_hsa05340	0.46079753
54	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.45971741
55	Type I diabetes mellitus_Homo sapiens_hsa04940	0.45089368
56	Choline metabolism in cancer_Homo sapiens_hsa05231	0.44280092
57	GnRH signaling pathway_Homo sapiens_hsa04912	0.43038402
58	Pyrimidine metabolism_Homo sapiens_hsa00240	0.40378412
59	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.39838689
60	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.39678134
61	TNF signaling pathway_Homo sapiens_hsa04668	0.38130522
62	Toxoplasmosis_Homo sapiens_hsa05145	0.36384285
63	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.35996971
64	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.34899787
65	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.34875885
66	Linoleic acid metabolism_Homo sapiens_hsa00591	0.34484339
67	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.33784188
68	Nucleotide excision repair_Homo sapiens_hsa03420	0.33231906
69	Chemical carcinogenesis_Homo sapiens_hsa05204	0.32442730
70	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.31624372
71	Protein digestion and absorption_Homo sapiens_hsa04974	0.29463802
72	Tyrosine metabolism_Homo sapiens_hsa00350	0.29111424
73	Phagosome_Homo sapiens_hsa04145	0.28682548
74	ABC transporters_Homo sapiens_hsa02010	0.28603869
75	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.27871840
76	Nitrogen metabolism_Homo sapiens_hsa00910	0.26704745
77	Purine metabolism_Homo sapiens_hsa00230	0.26024131
78	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.25863624
79	Fat digestion and absorption_Homo sapiens_hsa04975	0.25423879
80	ECM-receptor interaction_Homo sapiens_hsa04512	0.22519239
81	Phenylalanine metabolism_Homo sapiens_hsa00360	0.21955682
82	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.20552188
83	Rheumatoid arthritis_Homo sapiens_hsa05323	0.19825932
84	RNA transport_Homo sapiens_hsa03013	0.19168937
85	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.18681286
86	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.17829325
87	African trypanosomiasis_Homo sapiens_hsa05143	0.17382435
88	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.16771878
89	Renin-angiotensin system_Homo sapiens_hsa04614	0.16113368
90	Antigen processing and presentation_Homo sapiens_hsa04612	0.15755503
91	Tuberculosis_Homo sapiens_hsa05152	0.15356614
92	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.13346966
93	Bile secretion_Homo sapiens_hsa04976	0.13264384
94	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.11782722
95	MAPK signaling pathway_Homo sapiens_hsa04010	0.11050973
96	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.10432345
97	Rap1 signaling pathway_Homo sapiens_hsa04015	0.10107705
98	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.10069364
99	Calcium signaling pathway_Homo sapiens_hsa04020	0.08533705
100	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.08491229

GAPDHP36

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »