GAPDHP37

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)5.94491617
2chaperone-mediated protein transport (GO:0072321)5.04140441
3cullin deneddylation (GO:0010388)4.60717746
4negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.42312445
5protein deneddylation (GO:0000338)4.39593840
6rRNA modification (GO:0000154)4.35934567
7DNA deamination (GO:0045006)4.28414815
8water-soluble vitamin biosynthetic process (GO:0042364)4.24310809
9establishment of protein localization to mitochondrial membrane (GO:0090151)4.11531585
10positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.03858782
11rRNA methylation (GO:0031167)4.00353552
12regulation of cellular amino acid metabolic process (GO:0006521)4.00062260
13regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.00041634
14GTP biosynthetic process (GO:0006183)3.96819618
15ribosomal small subunit assembly (GO:0000028)3.96480109
16protein neddylation (GO:0045116)3.95856751
17negative regulation of ligase activity (GO:0051352)3.95792046
18negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.95792046
19establishment of integrated proviral latency (GO:0075713)3.95396319
20DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.93611666
21anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.86854725
22intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.81865177
23signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.81865177
24signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.81512184
25signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.81512184
26signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.81512184
27fatty acid elongation (GO:0030497)3.75899942
28protein maturation by protein folding (GO:0022417)3.74568410
29mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.70261002
30signal transduction involved in DNA integrity checkpoint (GO:0072401)3.64762063
31signal transduction involved in DNA damage checkpoint (GO:0072422)3.64762063
32nucleotide-excision repair, DNA gap filling (GO:0006297)3.64330682
33termination of RNA polymerase III transcription (GO:0006386)3.61532119
34transcription elongation from RNA polymerase III promoter (GO:0006385)3.61532119
35signal transduction involved in cell cycle checkpoint (GO:0072395)3.59054746
36NADH dehydrogenase complex assembly (GO:0010257)3.56438508
37mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.56438508
38mitochondrial respiratory chain complex I assembly (GO:0032981)3.56438508
39regulation of isotype switching to IgG isotypes (GO:0048302)3.56433957
40maturation of 5.8S rRNA (GO:0000460)3.55782837
41UTP biosynthetic process (GO:0006228)3.52342576
42pseudouridine synthesis (GO:0001522)3.51705494
43response to pheromone (GO:0019236)3.47886533
44positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.39678281
45protein complex biogenesis (GO:0070271)3.39618653
46signal peptide processing (GO:0006465)3.38558753
47negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.37991361
48positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.32774841
49positive regulation of ligase activity (GO:0051351)3.29140322
50DNA strand elongation involved in DNA replication (GO:0006271)3.27866819
51DNA strand elongation (GO:0022616)3.23087877
52regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.23035550
53guanosine-containing compound biosynthetic process (GO:1901070)3.18008605
54L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.17002929
55CENP-A containing nucleosome assembly (GO:0034080)3.16994839
56nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.15673134
57single strand break repair (GO:0000012)3.15319449
58establishment of viral latency (GO:0019043)3.14499595
59ribosomal large subunit biogenesis (GO:0042273)3.13690349
60regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.13181115
61telomere maintenance via semi-conservative replication (GO:0032201)3.12285098
62protein targeting to mitochondrion (GO:0006626)3.12254282
63chromatin remodeling at centromere (GO:0031055)3.11727166
64mitochondrial respiratory chain complex assembly (GO:0033108)3.11719099
65transcription-coupled nucleotide-excision repair (GO:0006283)3.11189424
66mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.09532310
67respiratory electron transport chain (GO:0022904)3.05234535
68UTP metabolic process (GO:0046051)3.05183354
69positive regulation of cell cycle arrest (GO:0071158)3.04571818
70respiratory chain complex IV assembly (GO:0008535)3.04321836
71translation (GO:0006412)3.04267570
72DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.04264890
73regulation of chronic inflammatory response (GO:0002676)3.03725446
74exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.02437548
75electron transport chain (GO:0022900)2.96149591
76regulation of ubiquitin-protein transferase activity (GO:0051438)2.92184273
77rRNA processing (GO:0006364)2.92143136
78metaphase plate congression (GO:0051310)2.90005154
79peptidyl-histidine modification (GO:0018202)2.89211029
80energy coupled proton transport, down electrochemical gradient (GO:0015985)2.86235869
81ATP synthesis coupled proton transport (GO:0015986)2.86235869
82negative regulation of calcium ion transport into cytosol (GO:0010523)2.85851123
83regulation of ligase activity (GO:0051340)2.85441430
84antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.84833450
85pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.84079296
86protein localization to mitochondrion (GO:0070585)2.84070397
87rRNA metabolic process (GO:0016072)2.83668904
88regulation of cellular amine metabolic process (GO:0033238)2.83668215
89CTP biosynthetic process (GO:0006241)2.80920383
90CTP metabolic process (GO:0046036)2.80920383
91RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.79262713
92tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.79262713
93establishment of protein localization to mitochondrion (GO:0072655)2.78277773
94mitotic metaphase plate congression (GO:0007080)2.77871189
95pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.75931613
96histone mRNA metabolic process (GO:0008334)2.74482800
97maturation of SSU-rRNA (GO:0030490)2.70874168
98G1/S transition of mitotic cell cycle (GO:0000082)2.68076356
99cell cycle G1/S phase transition (GO:0044843)2.68076356
100spliceosomal snRNP assembly (GO:0000387)2.67930769

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.76477488
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.70333877
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.35465616
4EST1_17652178_ChIP-ChIP_JURKAT_Human4.21634165
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.83447071
6ELF1_17652178_ChIP-ChIP_JURKAT_Human3.63151312
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.45561875
8CREB1_15753290_ChIP-ChIP_HEK293T_Human3.30804862
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.18129116
10ETS1_20019798_ChIP-Seq_JURKAT_Human3.18011655
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.05662420
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.97582522
13CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.90124048
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.89027048
15VDR_23849224_ChIP-Seq_CD4+_Human2.80142056
16MYC_18555785_ChIP-Seq_MESCs_Mouse2.75570364
17FOXP3_21729870_ChIP-Seq_TREG_Human2.51006108
18ELK1_19687146_ChIP-ChIP_HELA_Human2.48773724
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.45557979
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.25484184
21MYC_18358816_ChIP-ChIP_MESCs_Mouse2.21842899
22SRF_21415370_ChIP-Seq_HL-1_Mouse2.20339852
23MYC_19030024_ChIP-ChIP_MESCs_Mouse2.12871907
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.09253462
25VDR_22108803_ChIP-Seq_LS180_Human2.08079401
26DCP1A_22483619_ChIP-Seq_HELA_Human2.08077975
27EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.00887376
28THAP11_20581084_ChIP-Seq_MESCs_Mouse1.94132999
29PADI4_21655091_ChIP-ChIP_MCF-7_Human1.91355202
30PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.90997124
31MYC_19079543_ChIP-ChIP_MESCs_Mouse1.88359620
32FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.84404688
33YY1_21170310_ChIP-Seq_MESCs_Mouse1.82669667
34IGF1R_20145208_ChIP-Seq_DFB_Human1.81347851
35E2F1_18555785_ChIP-Seq_MESCs_Mouse1.80232978
36FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.76626901
37GABP_19822575_ChIP-Seq_HepG2_Human1.75765068
38CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.72681042
39FLI1_27457419_Chip-Seq_LIVER_Mouse1.65095089
40HOXB4_20404135_ChIP-ChIP_EML_Mouse1.61734224
41XRN2_22483619_ChIP-Seq_HELA_Human1.59272472
42TTF2_22483619_ChIP-Seq_HELA_Human1.51758726
43EWS_26573619_Chip-Seq_HEK293_Human1.49225832
44ELK1_22589737_ChIP-Seq_MCF10A_Human1.46672700
45ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.43185613
46RBPJ_22232070_ChIP-Seq_NCS_Mouse1.41620055
47ZNF274_21170338_ChIP-Seq_K562_Hela1.40581269
48POU5F1_16153702_ChIP-ChIP_HESCs_Human1.39865901
49PCGF2_27294783_Chip-Seq_ESCs_Mouse1.38824894
50E2F7_22180533_ChIP-Seq_HELA_Human1.35670813
51NELFA_20434984_ChIP-Seq_ESCs_Mouse1.33146442
52MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.31568104
53MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.30582775
54PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30194222
55YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.28463672
56POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.27303690
57BP1_19119308_ChIP-ChIP_Hs578T_Human1.27117958
58NOTCH1_21737748_ChIP-Seq_TLL_Human1.26887792
59MYC_18940864_ChIP-ChIP_HL60_Human1.25037907
60HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.22720965
61CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.21269154
62SOX2_18555785_ChIP-Seq_MESCs_Mouse1.20054209
63CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.19054882
64CTBP2_25329375_ChIP-Seq_LNCAP_Human1.16572060
65ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.14925976
66HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.12697221
67EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.12623602
68IRF1_19129219_ChIP-ChIP_H3396_Human1.12116236
69FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.07488775
70GATA1_26923725_Chip-Seq_HPCs_Mouse0.99884265
71CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.98482628
72FUS_26573619_Chip-Seq_HEK293_Human0.97844566
73NANOG_16153702_ChIP-ChIP_HESCs_Human0.93345986
74SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.92020351
75NANOG_18555785_ChIP-Seq_MESCs_Mouse0.91882494
76AUTS2_25519132_ChIP-Seq_293T-REX_Human0.88476703
77AR_20517297_ChIP-Seq_VCAP_Human0.88314894
78ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.87272580
79EZH2_22144423_ChIP-Seq_EOC_Human0.86050112
80CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.85729429
81PCGF2_27294783_Chip-Seq_NPCs_Mouse0.85301686
82FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.84507195
83CTBP1_25329375_ChIP-Seq_LNCAP_Human0.84382184
84BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.83823576
85FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83045599
86POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.82979871
87MYCN_18555785_ChIP-Seq_MESCs_Mouse0.81112269
88E2F1_21310950_ChIP-Seq_MCF-7_Human0.80723410
89MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.80599492
90ZFP57_27257070_Chip-Seq_ESCs_Mouse0.80126384
91TP53_22573176_ChIP-Seq_HFKS_Human0.79948832
92P300_19829295_ChIP-Seq_ESCs_Human0.79497961
93KDM5A_27292631_Chip-Seq_BREAST_Human0.79477543
94NCOR_22424771_ChIP-Seq_293T_Human0.77671759
95E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.75870315
96FOXA1_27270436_Chip-Seq_PROSTATE_Human0.75506015
97FOXA1_25329375_ChIP-Seq_VCAP_Human0.75506015
98ERG_20887958_ChIP-Seq_HPC-7_Mouse0.74579511
99POU3F2_20337985_ChIP-ChIP_501MEL_Human0.73944064
100GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.73631120

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002736_abnormal_nociception_after3.69648472
2MP0008058_abnormal_DNA_repair3.68375453
3MP0006292_abnormal_olfactory_placode3.16996724
4MP0005423_abnormal_somatic_nervous3.16654891
5MP0001968_abnormal_touch/_nociception2.83083452
6MP0008789_abnormal_olfactory_epithelium2.60079314
7MP0001873_stomach_inflammation2.49115779
8MP0003693_abnormal_embryo_hatching2.46488757
9MP0010094_abnormal_chromosome_stability2.45711574
10MP0002102_abnormal_ear_morphology2.44280659
11MP0002138_abnormal_hepatobiliary_system2.41351357
12MP0001986_abnormal_taste_sensitivity2.36818133
13MP0003186_abnormal_redox_activity2.24573487
14MP0003880_abnormal_central_pattern2.23107726
15MP0008877_abnormal_DNA_methylation2.22946811
16MP0001984_abnormal_olfaction2.20714774
17MP0003806_abnormal_nucleotide_metabolis2.17107974
18MP0005499_abnormal_olfactory_system2.09394886
19MP0005394_taste/olfaction_phenotype2.09394886
20MP0003718_maternal_effect2.06147249
21MP0005551_abnormal_eye_electrophysiolog1.96101910
22MP0000685_abnormal_immune_system1.85648728
23MP0006035_abnormal_mitochondrial_morpho1.79529058
24MP0002277_abnormal_respiratory_mucosa1.79020230
25MP0004957_abnormal_blastocyst_morpholog1.78341142
26MP0006072_abnormal_retinal_apoptosis1.78263243
27MP0003315_abnormal_perineum_morphology1.65291139
28MP0005671_abnormal_response_to1.62098131
29MP0008007_abnormal_cellular_replicative1.60363263
30MP0008875_abnormal_xenobiotic_pharmacok1.57634242
31MP0001905_abnormal_dopamine_level1.57341502
32MP0004885_abnormal_endolymph1.52153745
33MP0008932_abnormal_embryonic_tissue1.51834275
34MP0010368_abnormal_lymphatic_system1.51337774
35MP0000749_muscle_degeneration1.47302392
36MP0004782_abnormal_surfactant_physiolog1.44167145
37MP0001764_abnormal_homeostasis1.41170248
38MP0005084_abnormal_gallbladder_morpholo1.36112623
39MP0005410_abnormal_fertilization1.34886034
40MP0005167_abnormal_blood-brain_barrier1.33347158
41MP0008057_abnormal_DNA_replication1.32644441
42MP0009333_abnormal_splenocyte_physiolog1.31665741
43MP0001293_anophthalmia1.30364222
44MP0006036_abnormal_mitochondrial_physio1.29632881
45MP0003077_abnormal_cell_cycle1.27346597
46MP0003786_premature_aging1.26468923
47MP0002733_abnormal_thermal_nociception1.26343501
48MP0009053_abnormal_anal_canal1.26118520
49MP0002938_white_spotting1.25242869
50MP0003950_abnormal_plasma_membrane1.23641326
51MP0001529_abnormal_vocalization1.21557321
52MP0001835_abnormal_antigen_presentation1.20853616
53MP0002234_abnormal_pharynx_morphology1.20450362
54MP0001486_abnormal_startle_reflex1.18794606
55MP0009250_abnormal_appendicular_skeleto1.14672562
56MP0004147_increased_porphyrin_level1.11470275
57MP0004145_abnormal_muscle_electrophysio1.09211902
58MP0005253_abnormal_eye_physiology1.07259719
59MP0002272_abnormal_nervous_system1.06336066
60MP0002210_abnormal_sex_determination1.06325300
61MP0003119_abnormal_digestive_system1.04780798
62MP0004142_abnormal_muscle_tone1.04442859
63MP0002734_abnormal_mechanical_nocicepti1.03464536
64MP0005310_abnormal_salivary_gland1.00401947
65MP0001881_abnormal_mammary_gland0.97561158
66MP0008872_abnormal_physiological_respon0.96030537
67MP0001929_abnormal_gametogenesis0.93686622
68MP0001970_abnormal_pain_threshold0.92726511
69MP0003252_abnormal_bile_duct0.90181704
70MP0009745_abnormal_behavioral_response0.89522874
71MP0002090_abnormal_vision0.88805899
72MP0003011_delayed_dark_adaptation0.88734561
73MP0002160_abnormal_reproductive_system0.88150391
74MP0002233_abnormal_nose_morphology0.85707680
75MP0004215_abnormal_myocardial_fiber0.84593647
76MP0000653_abnormal_sex_gland0.83974928
77MP0005389_reproductive_system_phenotype0.80976072
78MP0002751_abnormal_autonomic_nervous0.80832202
79MP0002006_tumorigenesis0.78630498
80MP0003136_yellow_coat_color0.78554166
81MP0003123_paternal_imprinting0.78273777
82MP0003878_abnormal_ear_physiology0.77339371
83MP0005377_hearing/vestibular/ear_phenot0.77339371
84MP0001145_abnormal_male_reproductive0.74833920
85MP0003943_abnormal_hepatobiliary_system0.74645451
86MP0005165_increased_susceptibility_to0.74393864
87MP0002148_abnormal_hypersensitivity_rea0.74066641
88MP0002405_respiratory_system_inflammati0.73075095
89MP0000358_abnormal_cell_content/0.71305414
90MP0005395_other_phenotype0.70348609
91MP0010771_integument_phenotype0.70272787
92MP0003936_abnormal_reproductive_system0.70010732
93MP0001119_abnormal_female_reproductive0.69240676
94MP0003195_calcinosis0.68592177
95MP0002735_abnormal_chemical_nociception0.68047024
96MP0003698_abnormal_male_reproductive0.67648925
97MP0005195_abnormal_posterior_eye0.66886201
98MP0006276_abnormal_autonomic_nervous0.66052931
99MP0005501_abnormal_skin_physiology0.66051635
100MP0002752_abnormal_somatic_nervous0.62771312

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.13753204
2Mitochondrial inheritance (HP:0001427)4.38875811
3Progressive macrocephaly (HP:0004481)4.35103771
4Abnormal mitochondria in muscle tissue (HP:0008316)4.34489075
5Acute encephalopathy (HP:0006846)4.24414838
6Hepatocellular necrosis (HP:0001404)4.19785448
7Increased CSF lactate (HP:0002490)4.12036916
8Hepatic necrosis (HP:0002605)3.81889661
9Increased hepatocellular lipid droplets (HP:0006565)3.78961652
10Renal Fanconi syndrome (HP:0001994)3.69789786
11Lipid accumulation in hepatocytes (HP:0006561)3.46147522
12Increased serum pyruvate (HP:0003542)3.36032331
13Cerebral edema (HP:0002181)3.23823075
14Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.21514033
15Abnormality of the labia minora (HP:0012880)3.19104647
16Abnormality of glycolysis (HP:0004366)3.13441362
17Pancreatic cysts (HP:0001737)3.10747179
18Optic disc pallor (HP:0000543)2.92315365
19Absent/shortened dynein arms (HP:0200106)2.85302166
20Dynein arm defect of respiratory motile cilia (HP:0012255)2.85302166
21Increased serum lactate (HP:0002151)2.75174418
22Absent rod-and cone-mediated responses on ERG (HP:0007688)2.74688446
23Medial flaring of the eyebrow (HP:0010747)2.72030228
24Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.69544087
25Respiratory failure (HP:0002878)2.58393988
26Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.43546236
27Rhinitis (HP:0012384)2.43303264
28Birth length less than 3rd percentile (HP:0003561)2.43051073
29Exercise intolerance (HP:0003546)2.40825643
30Pancreatic fibrosis (HP:0100732)2.40464285
31Decreased electroretinogram (ERG) amplitude (HP:0000654)2.40210917
32Lactic acidosis (HP:0003128)2.37521207
33Aplasia/Hypoplasia involving the musculature (HP:0001460)2.35494412
34Methylmalonic aciduria (HP:0012120)2.34581067
35Methylmalonic acidemia (HP:0002912)2.34421679
36CNS demyelination (HP:0007305)2.30695969
37Large for gestational age (HP:0001520)2.29777725
38Chronic bronchitis (HP:0004469)2.25241102
39Entropion (HP:0000621)2.21476221
40Abnormality of the pons (HP:0007361)2.20971617
41Short tibia (HP:0005736)2.20844732
42Exertional dyspnea (HP:0002875)2.20187973
43Supernumerary spleens (HP:0009799)2.19619292
44Glycosuria (HP:0003076)2.19214887
45Abnormality of urine glucose concentration (HP:0011016)2.19214887
46Aplasia/Hypoplasia of the tibia (HP:0005772)2.19171849
47True hermaphroditism (HP:0010459)2.17584441
48Abnormality of the anterior horn cell (HP:0006802)2.16202042
49Degeneration of anterior horn cells (HP:0002398)2.16202042
50Congenital primary aphakia (HP:0007707)2.16141860
51Leukodystrophy (HP:0002415)2.15950662
52Abnormality of renal resorption (HP:0011038)2.15016077
53Lethargy (HP:0001254)2.13828341
54Aplasia/Hypoplasia of the tongue (HP:0010295)2.13079504
55Molar tooth sign on MRI (HP:0002419)2.10228628
56Abnormality of midbrain morphology (HP:0002418)2.10228628
57Gait imbalance (HP:0002141)2.08599830
58Cerebral hypomyelination (HP:0006808)2.04188555
59Congenital, generalized hypertrichosis (HP:0004540)2.01018691
60Genital tract atresia (HP:0001827)2.00270977
61Abnormal respiratory motile cilium physiology (HP:0012261)1.98894520
62Abnormality of cells of the erythroid lineage (HP:0012130)1.98874978
63Microglossia (HP:0000171)1.96874059
64IgM deficiency (HP:0002850)1.96804683
65Sensory axonal neuropathy (HP:0003390)1.94569119
66Abnormality of the ileum (HP:0001549)1.92854369
67Abnormality of the metopic suture (HP:0005556)1.92590930
68Constricted visual fields (HP:0001133)1.92423916
69Abnormal rod and cone electroretinograms (HP:0008323)1.92402233
70Meckel diverticulum (HP:0002245)1.91981505
71Fibular aplasia (HP:0002990)1.91828011
72Increased intramyocellular lipid droplets (HP:0012240)1.91490642
73Respiratory difficulties (HP:0002880)1.91209857
74Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.90009800
75Decreased activity of mitochondrial respiratory chain (HP:0008972)1.90009800
76Abnormal number of erythroid precursors (HP:0012131)1.90005010
77Abnormal respiratory motile cilium morphology (HP:0005938)1.88821738
78Abnormal respiratory epithelium morphology (HP:0012253)1.88821738
79Carpal bone hypoplasia (HP:0001498)1.88330316
80Progressive microcephaly (HP:0000253)1.87437440
81Emotional lability (HP:0000712)1.84685677
82Abnormality of T cell physiology (HP:0011840)1.84110321
83Prominent metopic ridge (HP:0005487)1.83313031
84Metaphyseal dysplasia (HP:0100255)1.82899394
85Abnormal ciliary motility (HP:0012262)1.82615644
86Adrenal hypoplasia (HP:0000835)1.78765790
87Reticulocytopenia (HP:0001896)1.78382811
88Blindness (HP:0000618)1.78279380
89Dyschromatopsia (HP:0007641)1.77145931
90Septo-optic dysplasia (HP:0100842)1.76898110
91Nephrogenic diabetes insipidus (HP:0009806)1.75333469
92Aplasia/hypoplasia of the uterus (HP:0008684)1.75176453
93Absent septum pellucidum (HP:0001331)1.73074200
94Colon cancer (HP:0003003)1.72948900
95Abnormal lung lobation (HP:0002101)1.72835419
96Decreased central vision (HP:0007663)1.72481159
97Postnatal microcephaly (HP:0005484)1.72422658
98Vaginal atresia (HP:0000148)1.72009444
99Abnormality of macular pigmentation (HP:0008002)1.70268959
100Abnormality of aspartate family amino acid metabolism (HP:0010899)1.70117904

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.99671698
2TXK3.62789302
3NME23.44717555
4TAF13.14847851
5EIF2AK32.90727355
6BUB12.81219800
7EIF2AK12.77815048
8SRPK12.66376140
9VRK12.63908304
10MAP4K22.55997217
11MST42.48594445
12NUAK12.09610255
13TRIM282.06475184
14GRK12.01548373
15TLK11.97776549
16TNIK1.93756534
17TSSK61.90063237
18PLK31.74072422
19ADRBK21.61966629
20EIF2AK21.58042179
21CCNB11.43241736
22SMG11.35591175
23CSNK1G11.35000329
24CSNK1G31.33352934
25NME11.32772112
26NEK11.31730841
27BCKDK1.28562917
28FRK1.27944205
29ZAK1.27377522
30MAPKAPK31.24022692
31CSNK1G21.23545557
32CSNK1A1L1.15867280
33STK161.14543057
34GRK51.10879214
35BCR1.10186265
36ACVR1B1.09364001
37PBK1.04200246
38BMPR1B1.01983860
39ARAF0.99413191
40LIMK10.92640001
41MAP2K70.92096997
42DAPK10.92041196
43MAPKAPK50.91499280
44WNK30.89266945
45PASK0.88841082
46PLK20.88495947
47PHKG10.87766225
48PHKG20.87766225
49CAMKK20.86149245
50BRSK20.85278258
51DYRK20.85142280
52PLK10.84909444
53CDC70.81695210
54MAP3K120.79920004
55CASK0.78583643
56PLK40.78572684
57WEE10.78250730
58INSRR0.77654159
59LRRK20.71322545
60MAP3K130.63745455
61ERBB30.58967497
62CDK90.57297726
63TTK0.56755333
64BRSK10.56391594
65MAP3K40.55507612
66ATR0.52784584
67MKNK20.49392767
68TIE10.46901759
69STK100.46391896
70EPHA40.45012708
71ERBB40.44911849
72MAP3K90.44569723
73KDR0.43714425
74RPS6KA50.42476791
75PRKCQ0.41836249
76TAOK30.41730883
77PRKCI0.41542868
78STK240.39547819
79AURKB0.38381788
80EPHB20.37920420
81CDK70.36955564
82AURKA0.36526937
83IKBKE0.36419654
84TGFBR10.36311435
85ADRBK10.33405179
86PRKCG0.32535974
87CSNK2A10.32041646
88CDK140.30974994
89FGFR10.30917750
90MAPK130.30605017
91TNK20.29476277
92STK390.29140167
93IRAK10.28338609
94CDK180.27897571
95CSNK2A20.27165731
96FER0.27106581
97CDK150.25731655
98STK40.25263437
99PRKCE0.24307047
100MKNK10.24256160

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.37624852
2Ribosome_Homo sapiens_hsa030103.30454648
3Oxidative phosphorylation_Homo sapiens_hsa001903.07940334
4Protein export_Homo sapiens_hsa030603.07802471
5Mismatch repair_Homo sapiens_hsa034303.01544001
6DNA replication_Homo sapiens_hsa030302.78113690
7RNA polymerase_Homo sapiens_hsa030202.68126388
8Parkinsons disease_Homo sapiens_hsa050122.61260514
9Homologous recombination_Homo sapiens_hsa034402.40509021
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.40103667
11Nucleotide excision repair_Homo sapiens_hsa034202.18824240
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.03476770
13Basal transcription factors_Homo sapiens_hsa030222.01005747
14One carbon pool by folate_Homo sapiens_hsa006701.92972681
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.92406868
16Huntingtons disease_Homo sapiens_hsa050161.88965480
17Fatty acid elongation_Homo sapiens_hsa000621.83227082
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.81608125
19Fanconi anemia pathway_Homo sapiens_hsa034601.79800942
20Pyrimidine metabolism_Homo sapiens_hsa002401.70865665
21Base excision repair_Homo sapiens_hsa034101.69154698
22Vitamin B6 metabolism_Homo sapiens_hsa007501.62396880
23Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.57933744
24RNA degradation_Homo sapiens_hsa030181.52377510
25Alzheimers disease_Homo sapiens_hsa050101.52266358
26RNA transport_Homo sapiens_hsa030131.41069806
27Spliceosome_Homo sapiens_hsa030401.40279608
28Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.37535960
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.33061693
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.29934831
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.28151653
32Phototransduction_Homo sapiens_hsa047441.26566193
33Pyruvate metabolism_Homo sapiens_hsa006201.21838332
34Biosynthesis of amino acids_Homo sapiens_hsa012301.17770180
35Peroxisome_Homo sapiens_hsa041461.17531419
36Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.16356493
37Propanoate metabolism_Homo sapiens_hsa006401.16277567
38Purine metabolism_Homo sapiens_hsa002301.15367701
39Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.13309173
40Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.07972361
41Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.07727865
42Cell cycle_Homo sapiens_hsa041101.03910568
43Collecting duct acid secretion_Homo sapiens_hsa049661.00697999
44Nitrogen metabolism_Homo sapiens_hsa009100.97658141
45Non-homologous end-joining_Homo sapiens_hsa034500.96946055
46Regulation of autophagy_Homo sapiens_hsa041400.95636088
47Glutathione metabolism_Homo sapiens_hsa004800.95152573
48Cardiac muscle contraction_Homo sapiens_hsa042600.94082420
49Folate biosynthesis_Homo sapiens_hsa007900.84627711
50Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.81443889
51Asthma_Homo sapiens_hsa053100.81425214
52Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.80329982
53Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.75337119
54Carbon metabolism_Homo sapiens_hsa012000.74744675
55Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.67545533
56p53 signaling pathway_Homo sapiens_hsa041150.67082922
57Rheumatoid arthritis_Homo sapiens_hsa053230.66729565
58Metabolic pathways_Homo sapiens_hsa011000.64969179
59Fatty acid degradation_Homo sapiens_hsa000710.59169939
60Oocyte meiosis_Homo sapiens_hsa041140.56475417
61Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.55996335
62Caffeine metabolism_Homo sapiens_hsa002320.55952591
63Tryptophan metabolism_Homo sapiens_hsa003800.48945730
64Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48374299
65alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.46561874
66Epstein-Barr virus infection_Homo sapiens_hsa051690.45552536
67N-Glycan biosynthesis_Homo sapiens_hsa005100.45462734
68Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.45428213
69Primary immunodeficiency_Homo sapiens_hsa053400.43901722
70Allograft rejection_Homo sapiens_hsa053300.41377839
71Fatty acid metabolism_Homo sapiens_hsa012120.40095714
72Vibrio cholerae infection_Homo sapiens_hsa051100.38976752
73Sulfur metabolism_Homo sapiens_hsa009200.38905066
74Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.38605588
75Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.38048073
76Antigen processing and presentation_Homo sapiens_hsa046120.37725665
77Primary bile acid biosynthesis_Homo sapiens_hsa001200.36960162
78Systemic lupus erythematosus_Homo sapiens_hsa053220.36904737
79Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.36776178
80Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.36553505
81Chemical carcinogenesis_Homo sapiens_hsa052040.36100228
82Drug metabolism - other enzymes_Homo sapiens_hsa009830.35986575
83Nicotine addiction_Homo sapiens_hsa050330.34803391
84Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34612609
85Linoleic acid metabolism_Homo sapiens_hsa005910.33375409
86Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.31608669
87Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.31450015
88Measles_Homo sapiens_hsa051620.30855147
89Arginine and proline metabolism_Homo sapiens_hsa003300.30566061
90Cyanoamino acid metabolism_Homo sapiens_hsa004600.29214769
91Morphine addiction_Homo sapiens_hsa050320.28833869
92Retinol metabolism_Homo sapiens_hsa008300.28153819
93Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.27810852
94Type I diabetes mellitus_Homo sapiens_hsa049400.25153897
95Autoimmune thyroid disease_Homo sapiens_hsa053200.24332541
96Steroid biosynthesis_Homo sapiens_hsa001000.22341287
97Pentose phosphate pathway_Homo sapiens_hsa000300.21901603
98Arachidonic acid metabolism_Homo sapiens_hsa005900.19600695
99Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.19494249
100Graft-versus-host disease_Homo sapiens_hsa053320.17672154

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