

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | proteasome assembly (GO:0043248) | 5.94491617 |
| 2 | chaperone-mediated protein transport (GO:0072321) | 5.04140441 |
| 3 | cullin deneddylation (GO:0010388) | 4.60717746 |
| 4 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.42312445 |
| 5 | protein deneddylation (GO:0000338) | 4.39593840 |
| 6 | rRNA modification (GO:0000154) | 4.35934567 |
| 7 | DNA deamination (GO:0045006) | 4.28414815 |
| 8 | water-soluble vitamin biosynthetic process (GO:0042364) | 4.24310809 |
| 9 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.11531585 |
| 10 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 4.03858782 |
| 11 | rRNA methylation (GO:0031167) | 4.00353552 |
| 12 | regulation of cellular amino acid metabolic process (GO:0006521) | 4.00062260 |
| 13 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 4.00041634 |
| 14 | GTP biosynthetic process (GO:0006183) | 3.96819618 |
| 15 | ribosomal small subunit assembly (GO:0000028) | 3.96480109 |
| 16 | protein neddylation (GO:0045116) | 3.95856751 |
| 17 | negative regulation of ligase activity (GO:0051352) | 3.95792046 |
| 18 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.95792046 |
| 19 | establishment of integrated proviral latency (GO:0075713) | 3.95396319 |
| 20 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.93611666 |
| 21 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.86854725 |
| 22 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.81865177 |
| 23 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.81865177 |
| 24 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.81512184 |
| 25 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.81512184 |
| 26 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.81512184 |
| 27 | fatty acid elongation (GO:0030497) | 3.75899942 |
| 28 | protein maturation by protein folding (GO:0022417) | 3.74568410 |
| 29 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.70261002 |
| 30 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.64762063 |
| 31 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.64762063 |
| 32 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 3.64330682 |
| 33 | termination of RNA polymerase III transcription (GO:0006386) | 3.61532119 |
| 34 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.61532119 |
| 35 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.59054746 |
| 36 | NADH dehydrogenase complex assembly (GO:0010257) | 3.56438508 |
| 37 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.56438508 |
| 38 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.56438508 |
| 39 | regulation of isotype switching to IgG isotypes (GO:0048302) | 3.56433957 |
| 40 | maturation of 5.8S rRNA (GO:0000460) | 3.55782837 |
| 41 | UTP biosynthetic process (GO:0006228) | 3.52342576 |
| 42 | pseudouridine synthesis (GO:0001522) | 3.51705494 |
| 43 | response to pheromone (GO:0019236) | 3.47886533 |
| 44 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.39678281 |
| 45 | protein complex biogenesis (GO:0070271) | 3.39618653 |
| 46 | signal peptide processing (GO:0006465) | 3.38558753 |
| 47 | negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315) | 3.37991361 |
| 48 | positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523) | 3.32774841 |
| 49 | positive regulation of ligase activity (GO:0051351) | 3.29140322 |
| 50 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.27866819 |
| 51 | DNA strand elongation (GO:0022616) | 3.23087877 |
| 52 | regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003339 | 3.23035550 |
| 53 | guanosine-containing compound biosynthetic process (GO:1901070) | 3.18008605 |
| 54 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 3.17002929 |
| 55 | CENP-A containing nucleosome assembly (GO:0034080) | 3.16994839 |
| 56 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.15673134 |
| 57 | single strand break repair (GO:0000012) | 3.15319449 |
| 58 | establishment of viral latency (GO:0019043) | 3.14499595 |
| 59 | ribosomal large subunit biogenesis (GO:0042273) | 3.13690349 |
| 60 | regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522) | 3.13181115 |
| 61 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.12285098 |
| 62 | protein targeting to mitochondrion (GO:0006626) | 3.12254282 |
| 63 | chromatin remodeling at centromere (GO:0031055) | 3.11727166 |
| 64 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.11719099 |
| 65 | transcription-coupled nucleotide-excision repair (GO:0006283) | 3.11189424 |
| 66 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.09532310 |
| 67 | respiratory electron transport chain (GO:0022904) | 3.05234535 |
| 68 | UTP metabolic process (GO:0046051) | 3.05183354 |
| 69 | positive regulation of cell cycle arrest (GO:0071158) | 3.04571818 |
| 70 | respiratory chain complex IV assembly (GO:0008535) | 3.04321836 |
| 71 | translation (GO:0006412) | 3.04267570 |
| 72 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 3.04264890 |
| 73 | regulation of chronic inflammatory response (GO:0002676) | 3.03725446 |
| 74 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.02437548 |
| 75 | electron transport chain (GO:0022900) | 2.96149591 |
| 76 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 2.92184273 |
| 77 | rRNA processing (GO:0006364) | 2.92143136 |
| 78 | metaphase plate congression (GO:0051310) | 2.90005154 |
| 79 | peptidyl-histidine modification (GO:0018202) | 2.89211029 |
| 80 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 2.86235869 |
| 81 | ATP synthesis coupled proton transport (GO:0015986) | 2.86235869 |
| 82 | negative regulation of calcium ion transport into cytosol (GO:0010523) | 2.85851123 |
| 83 | regulation of ligase activity (GO:0051340) | 2.85441430 |
| 84 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 2.84833450 |
| 85 | pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148) | 2.84079296 |
| 86 | protein localization to mitochondrion (GO:0070585) | 2.84070397 |
| 87 | rRNA metabolic process (GO:0016072) | 2.83668904 |
| 88 | regulation of cellular amine metabolic process (GO:0033238) | 2.83668215 |
| 89 | CTP biosynthetic process (GO:0006241) | 2.80920383 |
| 90 | CTP metabolic process (GO:0046036) | 2.80920383 |
| 91 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 2.79262713 |
| 92 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 2.79262713 |
| 93 | establishment of protein localization to mitochondrion (GO:0072655) | 2.78277773 |
| 94 | mitotic metaphase plate congression (GO:0007080) | 2.77871189 |
| 95 | pyrimidine nucleoside triphosphate metabolic process (GO:0009147) | 2.75931613 |
| 96 | histone mRNA metabolic process (GO:0008334) | 2.74482800 |
| 97 | maturation of SSU-rRNA (GO:0030490) | 2.70874168 |
| 98 | G1/S transition of mitotic cell cycle (GO:0000082) | 2.68076356 |
| 99 | cell cycle G1/S phase transition (GO:0044843) | 2.68076356 |
| 100 | spliceosomal snRNP assembly (GO:0000387) | 2.67930769 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 5.76477488 |
| 2 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.70333877 |
| 3 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 4.35465616 |
| 4 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 4.21634165 |
| 5 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 3.83447071 |
| 6 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 3.63151312 |
| 7 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.45561875 |
| 8 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.30804862 |
| 9 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.18129116 |
| 10 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.18011655 |
| 11 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 3.05662420 |
| 12 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.97582522 |
| 13 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.90124048 |
| 14 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.89027048 |
| 15 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.80142056 |
| 16 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.75570364 |
| 17 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.51006108 |
| 18 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.48773724 |
| 19 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.45557979 |
| 20 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.25484184 |
| 21 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.21842899 |
| 22 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.20339852 |
| 23 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.12871907 |
| 24 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 2.09253462 |
| 25 | VDR_22108803_ChIP-Seq_LS180_Human | 2.08079401 |
| 26 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.08077975 |
| 27 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 2.00887376 |
| 28 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.94132999 |
| 29 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.91355202 |
| 30 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.90997124 |
| 31 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.88359620 |
| 32 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.84404688 |
| 33 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.82669667 |
| 34 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.81347851 |
| 35 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.80232978 |
| 36 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.76626901 |
| 37 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.75765068 |
| 38 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.72681042 |
| 39 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.65095089 |
| 40 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.61734224 |
| 41 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.59272472 |
| 42 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.51758726 |
| 43 | EWS_26573619_Chip-Seq_HEK293_Human | 1.49225832 |
| 44 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.46672700 |
| 45 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.43185613 |
| 46 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.41620055 |
| 47 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.40581269 |
| 48 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.39865901 |
| 49 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.38824894 |
| 50 | E2F7_22180533_ChIP-Seq_HELA_Human | 1.35670813 |
| 51 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.33146442 |
| 52 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.31568104 |
| 53 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.30582775 |
| 54 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.30194222 |
| 55 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.28463672 |
| 56 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.27303690 |
| 57 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.27117958 |
| 58 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.26887792 |
| 59 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.25037907 |
| 60 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.22720965 |
| 61 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.21269154 |
| 62 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.20054209 |
| 63 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.19054882 |
| 64 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.16572060 |
| 65 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.14925976 |
| 66 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.12697221 |
| 67 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.12623602 |
| 68 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.12116236 |
| 69 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.07488775 |
| 70 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 0.99884265 |
| 71 | CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse | 0.98482628 |
| 72 | FUS_26573619_Chip-Seq_HEK293_Human | 0.97844566 |
| 73 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 0.93345986 |
| 74 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 0.92020351 |
| 75 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 0.91882494 |
| 76 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 0.88476703 |
| 77 | AR_20517297_ChIP-Seq_VCAP_Human | 0.88314894 |
| 78 | ATF3_23680149_ChIP-Seq_GBM1-GSC_Human | 0.87272580 |
| 79 | EZH2_22144423_ChIP-Seq_EOC_Human | 0.86050112 |
| 80 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.85729429 |
| 81 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 0.85301686 |
| 82 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.84507195 |
| 83 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 0.84382184 |
| 84 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 0.83823576 |
| 85 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.83045599 |
| 86 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 0.82979871 |
| 87 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 0.81112269 |
| 88 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 0.80723410 |
| 89 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 0.80599492 |
| 90 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 0.80126384 |
| 91 | TP53_22573176_ChIP-Seq_HFKS_Human | 0.79948832 |
| 92 | P300_19829295_ChIP-Seq_ESCs_Human | 0.79497961 |
| 93 | KDM5A_27292631_Chip-Seq_BREAST_Human | 0.79477543 |
| 94 | NCOR_22424771_ChIP-Seq_293T_Human | 0.77671759 |
| 95 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.75870315 |
| 96 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 0.75506015 |
| 97 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 0.75506015 |
| 98 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 0.74579511 |
| 99 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 0.73944064 |
| 100 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 0.73631120 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0002736_abnormal_nociception_after | 3.69648472 |
| 2 | MP0008058_abnormal_DNA_repair | 3.68375453 |
| 3 | MP0006292_abnormal_olfactory_placode | 3.16996724 |
| 4 | MP0005423_abnormal_somatic_nervous | 3.16654891 |
| 5 | MP0001968_abnormal_touch/_nociception | 2.83083452 |
| 6 | MP0008789_abnormal_olfactory_epithelium | 2.60079314 |
| 7 | MP0001873_stomach_inflammation | 2.49115779 |
| 8 | MP0003693_abnormal_embryo_hatching | 2.46488757 |
| 9 | MP0010094_abnormal_chromosome_stability | 2.45711574 |
| 10 | MP0002102_abnormal_ear_morphology | 2.44280659 |
| 11 | MP0002138_abnormal_hepatobiliary_system | 2.41351357 |
| 12 | MP0001986_abnormal_taste_sensitivity | 2.36818133 |
| 13 | MP0003186_abnormal_redox_activity | 2.24573487 |
| 14 | MP0003880_abnormal_central_pattern | 2.23107726 |
| 15 | MP0008877_abnormal_DNA_methylation | 2.22946811 |
| 16 | MP0001984_abnormal_olfaction | 2.20714774 |
| 17 | MP0003806_abnormal_nucleotide_metabolis | 2.17107974 |
| 18 | MP0005499_abnormal_olfactory_system | 2.09394886 |
| 19 | MP0005394_taste/olfaction_phenotype | 2.09394886 |
| 20 | MP0003718_maternal_effect | 2.06147249 |
| 21 | MP0005551_abnormal_eye_electrophysiolog | 1.96101910 |
| 22 | MP0000685_abnormal_immune_system | 1.85648728 |
| 23 | MP0006035_abnormal_mitochondrial_morpho | 1.79529058 |
| 24 | MP0002277_abnormal_respiratory_mucosa | 1.79020230 |
| 25 | MP0004957_abnormal_blastocyst_morpholog | 1.78341142 |
| 26 | MP0006072_abnormal_retinal_apoptosis | 1.78263243 |
| 27 | MP0003315_abnormal_perineum_morphology | 1.65291139 |
| 28 | MP0005671_abnormal_response_to | 1.62098131 |
| 29 | MP0008007_abnormal_cellular_replicative | 1.60363263 |
| 30 | MP0008875_abnormal_xenobiotic_pharmacok | 1.57634242 |
| 31 | MP0001905_abnormal_dopamine_level | 1.57341502 |
| 32 | MP0004885_abnormal_endolymph | 1.52153745 |
| 33 | MP0008932_abnormal_embryonic_tissue | 1.51834275 |
| 34 | MP0010368_abnormal_lymphatic_system | 1.51337774 |
| 35 | MP0000749_muscle_degeneration | 1.47302392 |
| 36 | MP0004782_abnormal_surfactant_physiolog | 1.44167145 |
| 37 | MP0001764_abnormal_homeostasis | 1.41170248 |
| 38 | MP0005084_abnormal_gallbladder_morpholo | 1.36112623 |
| 39 | MP0005410_abnormal_fertilization | 1.34886034 |
| 40 | MP0005167_abnormal_blood-brain_barrier | 1.33347158 |
| 41 | MP0008057_abnormal_DNA_replication | 1.32644441 |
| 42 | MP0009333_abnormal_splenocyte_physiolog | 1.31665741 |
| 43 | MP0001293_anophthalmia | 1.30364222 |
| 44 | MP0006036_abnormal_mitochondrial_physio | 1.29632881 |
| 45 | MP0003077_abnormal_cell_cycle | 1.27346597 |
| 46 | MP0003786_premature_aging | 1.26468923 |
| 47 | MP0002733_abnormal_thermal_nociception | 1.26343501 |
| 48 | MP0009053_abnormal_anal_canal | 1.26118520 |
| 49 | MP0002938_white_spotting | 1.25242869 |
| 50 | MP0003950_abnormal_plasma_membrane | 1.23641326 |
| 51 | MP0001529_abnormal_vocalization | 1.21557321 |
| 52 | MP0001835_abnormal_antigen_presentation | 1.20853616 |
| 53 | MP0002234_abnormal_pharynx_morphology | 1.20450362 |
| 54 | MP0001486_abnormal_startle_reflex | 1.18794606 |
| 55 | MP0009250_abnormal_appendicular_skeleto | 1.14672562 |
| 56 | MP0004147_increased_porphyrin_level | 1.11470275 |
| 57 | MP0004145_abnormal_muscle_electrophysio | 1.09211902 |
| 58 | MP0005253_abnormal_eye_physiology | 1.07259719 |
| 59 | MP0002272_abnormal_nervous_system | 1.06336066 |
| 60 | MP0002210_abnormal_sex_determination | 1.06325300 |
| 61 | MP0003119_abnormal_digestive_system | 1.04780798 |
| 62 | MP0004142_abnormal_muscle_tone | 1.04442859 |
| 63 | MP0002734_abnormal_mechanical_nocicepti | 1.03464536 |
| 64 | MP0005310_abnormal_salivary_gland | 1.00401947 |
| 65 | MP0001881_abnormal_mammary_gland | 0.97561158 |
| 66 | MP0008872_abnormal_physiological_respon | 0.96030537 |
| 67 | MP0001929_abnormal_gametogenesis | 0.93686622 |
| 68 | MP0001970_abnormal_pain_threshold | 0.92726511 |
| 69 | MP0003252_abnormal_bile_duct | 0.90181704 |
| 70 | MP0009745_abnormal_behavioral_response | 0.89522874 |
| 71 | MP0002090_abnormal_vision | 0.88805899 |
| 72 | MP0003011_delayed_dark_adaptation | 0.88734561 |
| 73 | MP0002160_abnormal_reproductive_system | 0.88150391 |
| 74 | MP0002233_abnormal_nose_morphology | 0.85707680 |
| 75 | MP0004215_abnormal_myocardial_fiber | 0.84593647 |
| 76 | MP0000653_abnormal_sex_gland | 0.83974928 |
| 77 | MP0005389_reproductive_system_phenotype | 0.80976072 |
| 78 | MP0002751_abnormal_autonomic_nervous | 0.80832202 |
| 79 | MP0002006_tumorigenesis | 0.78630498 |
| 80 | MP0003136_yellow_coat_color | 0.78554166 |
| 81 | MP0003123_paternal_imprinting | 0.78273777 |
| 82 | MP0003878_abnormal_ear_physiology | 0.77339371 |
| 83 | MP0005377_hearing/vestibular/ear_phenot | 0.77339371 |
| 84 | MP0001145_abnormal_male_reproductive | 0.74833920 |
| 85 | MP0003943_abnormal_hepatobiliary_system | 0.74645451 |
| 86 | MP0005165_increased_susceptibility_to | 0.74393864 |
| 87 | MP0002148_abnormal_hypersensitivity_rea | 0.74066641 |
| 88 | MP0002405_respiratory_system_inflammati | 0.73075095 |
| 89 | MP0000358_abnormal_cell_content/ | 0.71305414 |
| 90 | MP0005395_other_phenotype | 0.70348609 |
| 91 | MP0010771_integument_phenotype | 0.70272787 |
| 92 | MP0003936_abnormal_reproductive_system | 0.70010732 |
| 93 | MP0001119_abnormal_female_reproductive | 0.69240676 |
| 94 | MP0003195_calcinosis | 0.68592177 |
| 95 | MP0002735_abnormal_chemical_nociception | 0.68047024 |
| 96 | MP0003698_abnormal_male_reproductive | 0.67648925 |
| 97 | MP0005195_abnormal_posterior_eye | 0.66886201 |
| 98 | MP0006276_abnormal_autonomic_nervous | 0.66052931 |
| 99 | MP0005501_abnormal_skin_physiology | 0.66051635 |
| 100 | MP0002752_abnormal_somatic_nervous | 0.62771312 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 5.13753204 |
| 2 | Mitochondrial inheritance (HP:0001427) | 4.38875811 |
| 3 | Progressive macrocephaly (HP:0004481) | 4.35103771 |
| 4 | Abnormal mitochondria in muscle tissue (HP:0008316) | 4.34489075 |
| 5 | Acute encephalopathy (HP:0006846) | 4.24414838 |
| 6 | Hepatocellular necrosis (HP:0001404) | 4.19785448 |
| 7 | Increased CSF lactate (HP:0002490) | 4.12036916 |
| 8 | Hepatic necrosis (HP:0002605) | 3.81889661 |
| 9 | Increased hepatocellular lipid droplets (HP:0006565) | 3.78961652 |
| 10 | Renal Fanconi syndrome (HP:0001994) | 3.69789786 |
| 11 | Lipid accumulation in hepatocytes (HP:0006561) | 3.46147522 |
| 12 | Increased serum pyruvate (HP:0003542) | 3.36032331 |
| 13 | Cerebral edema (HP:0002181) | 3.23823075 |
| 14 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 3.21514033 |
| 15 | Abnormality of the labia minora (HP:0012880) | 3.19104647 |
| 16 | Abnormality of glycolysis (HP:0004366) | 3.13441362 |
| 17 | Pancreatic cysts (HP:0001737) | 3.10747179 |
| 18 | Optic disc pallor (HP:0000543) | 2.92315365 |
| 19 | Absent/shortened dynein arms (HP:0200106) | 2.85302166 |
| 20 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 2.85302166 |
| 21 | Increased serum lactate (HP:0002151) | 2.75174418 |
| 22 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 2.74688446 |
| 23 | Medial flaring of the eyebrow (HP:0010747) | 2.72030228 |
| 24 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.69544087 |
| 25 | Respiratory failure (HP:0002878) | 2.58393988 |
| 26 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.43546236 |
| 27 | Rhinitis (HP:0012384) | 2.43303264 |
| 28 | Birth length less than 3rd percentile (HP:0003561) | 2.43051073 |
| 29 | Exercise intolerance (HP:0003546) | 2.40825643 |
| 30 | Pancreatic fibrosis (HP:0100732) | 2.40464285 |
| 31 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 2.40210917 |
| 32 | Lactic acidosis (HP:0003128) | 2.37521207 |
| 33 | Aplasia/Hypoplasia involving the musculature (HP:0001460) | 2.35494412 |
| 34 | Methylmalonic aciduria (HP:0012120) | 2.34581067 |
| 35 | Methylmalonic acidemia (HP:0002912) | 2.34421679 |
| 36 | CNS demyelination (HP:0007305) | 2.30695969 |
| 37 | Large for gestational age (HP:0001520) | 2.29777725 |
| 38 | Chronic bronchitis (HP:0004469) | 2.25241102 |
| 39 | Entropion (HP:0000621) | 2.21476221 |
| 40 | Abnormality of the pons (HP:0007361) | 2.20971617 |
| 41 | Short tibia (HP:0005736) | 2.20844732 |
| 42 | Exertional dyspnea (HP:0002875) | 2.20187973 |
| 43 | Supernumerary spleens (HP:0009799) | 2.19619292 |
| 44 | Glycosuria (HP:0003076) | 2.19214887 |
| 45 | Abnormality of urine glucose concentration (HP:0011016) | 2.19214887 |
| 46 | Aplasia/Hypoplasia of the tibia (HP:0005772) | 2.19171849 |
| 47 | True hermaphroditism (HP:0010459) | 2.17584441 |
| 48 | Abnormality of the anterior horn cell (HP:0006802) | 2.16202042 |
| 49 | Degeneration of anterior horn cells (HP:0002398) | 2.16202042 |
| 50 | Congenital primary aphakia (HP:0007707) | 2.16141860 |
| 51 | Leukodystrophy (HP:0002415) | 2.15950662 |
| 52 | Abnormality of renal resorption (HP:0011038) | 2.15016077 |
| 53 | Lethargy (HP:0001254) | 2.13828341 |
| 54 | Aplasia/Hypoplasia of the tongue (HP:0010295) | 2.13079504 |
| 55 | Molar tooth sign on MRI (HP:0002419) | 2.10228628 |
| 56 | Abnormality of midbrain morphology (HP:0002418) | 2.10228628 |
| 57 | Gait imbalance (HP:0002141) | 2.08599830 |
| 58 | Cerebral hypomyelination (HP:0006808) | 2.04188555 |
| 59 | Congenital, generalized hypertrichosis (HP:0004540) | 2.01018691 |
| 60 | Genital tract atresia (HP:0001827) | 2.00270977 |
| 61 | Abnormal respiratory motile cilium physiology (HP:0012261) | 1.98894520 |
| 62 | Abnormality of cells of the erythroid lineage (HP:0012130) | 1.98874978 |
| 63 | Microglossia (HP:0000171) | 1.96874059 |
| 64 | IgM deficiency (HP:0002850) | 1.96804683 |
| 65 | Sensory axonal neuropathy (HP:0003390) | 1.94569119 |
| 66 | Abnormality of the ileum (HP:0001549) | 1.92854369 |
| 67 | Abnormality of the metopic suture (HP:0005556) | 1.92590930 |
| 68 | Constricted visual fields (HP:0001133) | 1.92423916 |
| 69 | Abnormal rod and cone electroretinograms (HP:0008323) | 1.92402233 |
| 70 | Meckel diverticulum (HP:0002245) | 1.91981505 |
| 71 | Fibular aplasia (HP:0002990) | 1.91828011 |
| 72 | Increased intramyocellular lipid droplets (HP:0012240) | 1.91490642 |
| 73 | Respiratory difficulties (HP:0002880) | 1.91209857 |
| 74 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 1.90009800 |
| 75 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 1.90009800 |
| 76 | Abnormal number of erythroid precursors (HP:0012131) | 1.90005010 |
| 77 | Abnormal respiratory motile cilium morphology (HP:0005938) | 1.88821738 |
| 78 | Abnormal respiratory epithelium morphology (HP:0012253) | 1.88821738 |
| 79 | Carpal bone hypoplasia (HP:0001498) | 1.88330316 |
| 80 | Progressive microcephaly (HP:0000253) | 1.87437440 |
| 81 | Emotional lability (HP:0000712) | 1.84685677 |
| 82 | Abnormality of T cell physiology (HP:0011840) | 1.84110321 |
| 83 | Prominent metopic ridge (HP:0005487) | 1.83313031 |
| 84 | Metaphyseal dysplasia (HP:0100255) | 1.82899394 |
| 85 | Abnormal ciliary motility (HP:0012262) | 1.82615644 |
| 86 | Adrenal hypoplasia (HP:0000835) | 1.78765790 |
| 87 | Reticulocytopenia (HP:0001896) | 1.78382811 |
| 88 | Blindness (HP:0000618) | 1.78279380 |
| 89 | Dyschromatopsia (HP:0007641) | 1.77145931 |
| 90 | Septo-optic dysplasia (HP:0100842) | 1.76898110 |
| 91 | Nephrogenic diabetes insipidus (HP:0009806) | 1.75333469 |
| 92 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.75176453 |
| 93 | Absent septum pellucidum (HP:0001331) | 1.73074200 |
| 94 | Colon cancer (HP:0003003) | 1.72948900 |
| 95 | Abnormal lung lobation (HP:0002101) | 1.72835419 |
| 96 | Decreased central vision (HP:0007663) | 1.72481159 |
| 97 | Postnatal microcephaly (HP:0005484) | 1.72422658 |
| 98 | Vaginal atresia (HP:0000148) | 1.72009444 |
| 99 | Abnormality of macular pigmentation (HP:0008002) | 1.70268959 |
| 100 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 1.70117904 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | VRK2 | 5.99671698 |
| 2 | TXK | 3.62789302 |
| 3 | NME2 | 3.44717555 |
| 4 | TAF1 | 3.14847851 |
| 5 | EIF2AK3 | 2.90727355 |
| 6 | BUB1 | 2.81219800 |
| 7 | EIF2AK1 | 2.77815048 |
| 8 | SRPK1 | 2.66376140 |
| 9 | VRK1 | 2.63908304 |
| 10 | MAP4K2 | 2.55997217 |
| 11 | MST4 | 2.48594445 |
| 12 | NUAK1 | 2.09610255 |
| 13 | TRIM28 | 2.06475184 |
| 14 | GRK1 | 2.01548373 |
| 15 | TLK1 | 1.97776549 |
| 16 | TNIK | 1.93756534 |
| 17 | TSSK6 | 1.90063237 |
| 18 | PLK3 | 1.74072422 |
| 19 | ADRBK2 | 1.61966629 |
| 20 | EIF2AK2 | 1.58042179 |
| 21 | CCNB1 | 1.43241736 |
| 22 | SMG1 | 1.35591175 |
| 23 | CSNK1G1 | 1.35000329 |
| 24 | CSNK1G3 | 1.33352934 |
| 25 | NME1 | 1.32772112 |
| 26 | NEK1 | 1.31730841 |
| 27 | BCKDK | 1.28562917 |
| 28 | FRK | 1.27944205 |
| 29 | ZAK | 1.27377522 |
| 30 | MAPKAPK3 | 1.24022692 |
| 31 | CSNK1G2 | 1.23545557 |
| 32 | CSNK1A1L | 1.15867280 |
| 33 | STK16 | 1.14543057 |
| 34 | GRK5 | 1.10879214 |
| 35 | BCR | 1.10186265 |
| 36 | ACVR1B | 1.09364001 |
| 37 | PBK | 1.04200246 |
| 38 | BMPR1B | 1.01983860 |
| 39 | ARAF | 0.99413191 |
| 40 | LIMK1 | 0.92640001 |
| 41 | MAP2K7 | 0.92096997 |
| 42 | DAPK1 | 0.92041196 |
| 43 | MAPKAPK5 | 0.91499280 |
| 44 | WNK3 | 0.89266945 |
| 45 | PASK | 0.88841082 |
| 46 | PLK2 | 0.88495947 |
| 47 | PHKG1 | 0.87766225 |
| 48 | PHKG2 | 0.87766225 |
| 49 | CAMKK2 | 0.86149245 |
| 50 | BRSK2 | 0.85278258 |
| 51 | DYRK2 | 0.85142280 |
| 52 | PLK1 | 0.84909444 |
| 53 | CDC7 | 0.81695210 |
| 54 | MAP3K12 | 0.79920004 |
| 55 | CASK | 0.78583643 |
| 56 | PLK4 | 0.78572684 |
| 57 | WEE1 | 0.78250730 |
| 58 | INSRR | 0.77654159 |
| 59 | LRRK2 | 0.71322545 |
| 60 | MAP3K13 | 0.63745455 |
| 61 | ERBB3 | 0.58967497 |
| 62 | CDK9 | 0.57297726 |
| 63 | TTK | 0.56755333 |
| 64 | BRSK1 | 0.56391594 |
| 65 | MAP3K4 | 0.55507612 |
| 66 | ATR | 0.52784584 |
| 67 | MKNK2 | 0.49392767 |
| 68 | TIE1 | 0.46901759 |
| 69 | STK10 | 0.46391896 |
| 70 | EPHA4 | 0.45012708 |
| 71 | ERBB4 | 0.44911849 |
| 72 | MAP3K9 | 0.44569723 |
| 73 | KDR | 0.43714425 |
| 74 | RPS6KA5 | 0.42476791 |
| 75 | PRKCQ | 0.41836249 |
| 76 | TAOK3 | 0.41730883 |
| 77 | PRKCI | 0.41542868 |
| 78 | STK24 | 0.39547819 |
| 79 | AURKB | 0.38381788 |
| 80 | EPHB2 | 0.37920420 |
| 81 | CDK7 | 0.36955564 |
| 82 | AURKA | 0.36526937 |
| 83 | IKBKE | 0.36419654 |
| 84 | TGFBR1 | 0.36311435 |
| 85 | ADRBK1 | 0.33405179 |
| 86 | PRKCG | 0.32535974 |
| 87 | CSNK2A1 | 0.32041646 |
| 88 | CDK14 | 0.30974994 |
| 89 | FGFR1 | 0.30917750 |
| 90 | MAPK13 | 0.30605017 |
| 91 | TNK2 | 0.29476277 |
| 92 | STK39 | 0.29140167 |
| 93 | IRAK1 | 0.28338609 |
| 94 | CDK18 | 0.27897571 |
| 95 | CSNK2A2 | 0.27165731 |
| 96 | FER | 0.27106581 |
| 97 | CDK15 | 0.25731655 |
| 98 | STK4 | 0.25263437 |
| 99 | PRKCE | 0.24307047 |
| 100 | MKNK1 | 0.24256160 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 5.37624852 |
| 2 | Ribosome_Homo sapiens_hsa03010 | 3.30454648 |
| 3 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.07940334 |
| 4 | Protein export_Homo sapiens_hsa03060 | 3.07802471 |
| 5 | Mismatch repair_Homo sapiens_hsa03430 | 3.01544001 |
| 6 | DNA replication_Homo sapiens_hsa03030 | 2.78113690 |
| 7 | RNA polymerase_Homo sapiens_hsa03020 | 2.68126388 |
| 8 | Parkinsons disease_Homo sapiens_hsa05012 | 2.61260514 |
| 9 | Homologous recombination_Homo sapiens_hsa03440 | 2.40509021 |
| 10 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.40103667 |
| 11 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.18824240 |
| 12 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 2.03476770 |
| 13 | Basal transcription factors_Homo sapiens_hsa03022 | 2.01005747 |
| 14 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.92972681 |
| 15 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.92406868 |
| 16 | Huntingtons disease_Homo sapiens_hsa05016 | 1.88965480 |
| 17 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.83227082 |
| 18 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.81608125 |
| 19 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.79800942 |
| 20 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.70865665 |
| 21 | Base excision repair_Homo sapiens_hsa03410 | 1.69154698 |
| 22 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.62396880 |
| 23 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.57933744 |
| 24 | RNA degradation_Homo sapiens_hsa03018 | 1.52377510 |
| 25 | Alzheimers disease_Homo sapiens_hsa05010 | 1.52266358 |
| 26 | RNA transport_Homo sapiens_hsa03013 | 1.41069806 |
| 27 | Spliceosome_Homo sapiens_hsa03040 | 1.40279608 |
| 28 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.37535960 |
| 29 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.33061693 |
| 30 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.29934831 |
| 31 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.28151653 |
| 32 | Phototransduction_Homo sapiens_hsa04744 | 1.26566193 |
| 33 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.21838332 |
| 34 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.17770180 |
| 35 | Peroxisome_Homo sapiens_hsa04146 | 1.17531419 |
| 36 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.16356493 |
| 37 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.16277567 |
| 38 | Purine metabolism_Homo sapiens_hsa00230 | 1.15367701 |
| 39 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.13309173 |
| 40 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.07972361 |
| 41 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 1.07727865 |
| 42 | Cell cycle_Homo sapiens_hsa04110 | 1.03910568 |
| 43 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.00697999 |
| 44 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.97658141 |
| 45 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.96946055 |
| 46 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.95636088 |
| 47 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.95152573 |
| 48 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.94082420 |
| 49 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.84627711 |
| 50 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.81443889 |
| 51 | Asthma_Homo sapiens_hsa05310 | 0.81425214 |
| 52 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.80329982 |
| 53 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.75337119 |
| 54 | Carbon metabolism_Homo sapiens_hsa01200 | 0.74744675 |
| 55 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.67545533 |
| 56 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.67082922 |
| 57 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.66729565 |
| 58 | Metabolic pathways_Homo sapiens_hsa01100 | 0.64969179 |
| 59 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.59169939 |
| 60 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.56475417 |
| 61 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.55996335 |
| 62 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.55952591 |
| 63 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.48945730 |
| 64 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.48374299 |
| 65 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.46561874 |
| 66 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.45552536 |
| 67 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.45462734 |
| 68 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.45428213 |
| 69 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.43901722 |
| 70 | Allograft rejection_Homo sapiens_hsa05330 | 0.41377839 |
| 71 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.40095714 |
| 72 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.38976752 |
| 73 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.38905066 |
| 74 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.38605588 |
| 75 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.38048073 |
| 76 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.37725665 |
| 77 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.36960162 |
| 78 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.36904737 |
| 79 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.36776178 |
| 80 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.36553505 |
| 81 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.36100228 |
| 82 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.35986575 |
| 83 | Nicotine addiction_Homo sapiens_hsa05033 | 0.34803391 |
| 84 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.34612609 |
| 85 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.33375409 |
| 86 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.31608669 |
| 87 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.31450015 |
| 88 | Measles_Homo sapiens_hsa05162 | 0.30855147 |
| 89 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.30566061 |
| 90 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.29214769 |
| 91 | Morphine addiction_Homo sapiens_hsa05032 | 0.28833869 |
| 92 | Retinol metabolism_Homo sapiens_hsa00830 | 0.28153819 |
| 93 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.27810852 |
| 94 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.25153897 |
| 95 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.24332541 |
| 96 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.22341287 |
| 97 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.21901603 |
| 98 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.19600695 |
| 99 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.19494249 |
| 100 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.17672154 |

