ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	8.61154441
2	positive regulation of mitotic sister chromatid separation (GO:1901970)	8.61154441
3	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	8.61154441
4	eosinophil chemotaxis (GO:0048245)	8.10727465
5	negative regulation of T cell receptor signaling pathway (GO:0050860)	7.95854496
6	negative regulation of Ras GTPase activity (GO:0034261)	7.91205778
7	L-fucose catabolic process (GO:0042355)	7.51494950
8	fucose catabolic process (GO:0019317)	7.51494950
9	L-fucose metabolic process (GO:0042354)	7.51494950
10	eosinophil migration (GO:0072677)	7.31572334
11	regulation of sister chromatid cohesion (GO:0007063)	6.65693011
12	regulation of mononuclear cell migration (GO:0071675)	6.60879467
13	negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)	6.30770167
14	ribosomal small subunit assembly (GO:0000028)	6.18540452
15	negative regulation of peptidyl-threonine phosphorylation (GO:0010801)	5.97320051
16	branch elongation of an epithelium (GO:0060602)	5.94618982
17	vesicle fusion (GO:0006906)	5.89466662
18	proteasome assembly (GO:0043248)	5.58526541
19	positive regulation of chromosome segregation (GO:0051984)	5.56323313
20	regulation of T cell receptor signaling pathway (GO:0050856)	5.35879134
21	autophagic vacuole fusion (GO:0000046)	5.23122130
22	coenzyme A biosynthetic process (GO:0015937)	5.17206539
23	macrophage chemotaxis (GO:0048246)	5.02606335
24	negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)	4.82569396
25	non-recombinational repair (GO:0000726)	4.52818341
26	double-strand break repair via nonhomologous end joining (GO:0006303)	4.52818341
27	organ growth (GO:0035265)	4.37952401
28	organelle membrane fusion (GO:0090174)	4.36543307
29	metallo-sulfur cluster assembly (GO:0031163)	4.35773781
30	iron-sulfur cluster assembly (GO:0016226)	4.35773781
31	protein import into peroxisome matrix (GO:0016558)	4.27044702
32	localization within membrane (GO:0051668)	4.16916432
33	regulation of nitric-oxide synthase biosynthetic process (GO:0051769)	4.16769581
34	positive regulation of calcium ion import (GO:0090280)	4.10201085
35	oxidative demethylation (GO:0070989)	4.09549363
36	preassembly of GPI anchor in ER membrane (GO:0016254)	4.05479159
37	fucose metabolic process (GO:0006004)	4.03183027
38	fucosylation (GO:0036065)	4.03104102
39	peptidyl-lysine dimethylation (GO:0018027)	3.93855546
40	detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)	3.92960590
41	axis elongation (GO:0003401)	3.91856682
42	pantothenate metabolic process (GO:0015939)	3.91220714
43	monocyte chemotaxis (GO:0002548)	3.87904723
44	regulation of antigen receptor-mediated signaling pathway (GO:0050854)	3.76730978
45	acrosome assembly (GO:0001675)	3.73695862
46	organelle fusion (GO:0048284)	3.69102593
47	DNA integration (GO:0015074)	3.68270238
48	DNA demethylation (GO:0080111)	3.63818797
49	DNA deamination (GO:0045006)	3.61168788
50	seminiferous tubule development (GO:0072520)	3.51894220
51	detection of chemical stimulus involved in sensory perception of taste (GO:0050912)	3.45529568
52	coenzyme A metabolic process (GO:0015936)	3.40891723
53	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	3.38400720
54	negative regulation of GTP catabolic process (GO:0033125)	3.29443699
55	negative regulation of GTPase activity (GO:0034260)	3.29443699
56	RNA methylation (GO:0001510)	3.28583445
57	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.28525392
58	termination of RNA polymerase III transcription (GO:0006386)	3.28525392
59	protein targeting to peroxisome (GO:0006625)	3.26827601
60	establishment of protein localization to peroxisome (GO:0072663)	3.26827601
61	protein localization to peroxisome (GO:0072662)	3.26827601
62	response to pheromone (GO:0019236)	3.25863951
63	regulation of cellular amino acid metabolic process (GO:0006521)	3.24676657
64	single-organism membrane fusion (GO:0044801)	3.21688285
65	positive chemotaxis (GO:0050918)	3.21459414
66	ribonucleoside bisphosphate biosynthetic process (GO:0034030)	3.19220484
67	nucleoside bisphosphate biosynthetic process (GO:0033866)	3.19220484
68	purine nucleoside bisphosphate biosynthetic process (GO:0034033)	3.19220484
69	ER to Golgi vesicle-mediated transport (GO:0006888)	3.18406788
70	folic acid-containing compound biosynthetic process (GO:0009396)	3.18017720
71	establishment of mitotic spindle orientation (GO:0000132)	3.16141202
72	GPI anchor biosynthetic process (GO:0006506)	3.15112869
73	mitochondrial RNA metabolic process (GO:0000959)	3.14951330
74	tRNA modification (GO:0006400)	3.12430729
75	telomere maintenance via recombination (GO:0000722)	3.11454950
76	intracellular protein transmembrane import (GO:0044743)	3.10730865
77	negative regulation of circadian rhythm (GO:0042754)	3.07939590
78	regulation of beta-amyloid formation (GO:1902003)	3.04522794
79	membrane budding (GO:0006900)	3.01849164
80	GPI anchor metabolic process (GO:0006505)	3.00876210
81	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.97239712
82	histone H3-K9 methylation (GO:0051567)	2.96963860
83	regulation of T cell apoptotic process (GO:0070232)	2.96383358
84	protein sumoylation (GO:0016925)	2.95075676
85	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.94758374
86	DNA dealkylation (GO:0035510)	2.92906645
87	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.88493453
88	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.88493453
89	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.88493453
90	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.87593285
91	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.87593285
92	peroxisomal transport (GO:0043574)	2.85174324
93	protein neddylation (GO:0045116)	2.84582726
94	regulation of autophagic vacuole assembly (GO:2000785)	2.84537900
95	RNA modification (GO:0009451)	2.82694453
96	lipid particle organization (GO:0034389)	2.81793372
97	establishment of mitotic spindle localization (GO:0040001)	2.81087960
98	negative regulation of macroautophagy (GO:0016242)	2.80601698
99	prenylation (GO:0097354)	10.3138550
100	protein prenylation (GO:0018342)	10.3138550

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	8.14899289
2	GATA1_22025678_ChIP-Seq_K562_Human	5.74955937
3	VDR_22108803_ChIP-Seq_LS180_Human	5.08816473
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.86426443
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.92135971
6	NOTCH1_21737748_ChIP-Seq_TLL_Human	3.90811174
7	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.96785148
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.86212360
9	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.85429958
10	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.78897698
11	ZNF274_21170338_ChIP-Seq_K562_Hela	2.60585092
12	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.59782945
13	YY1_21170310_ChIP-Seq_MESCs_Mouse	2.58311485
14	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.56944246
15	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.51346079
16	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.48873471
17	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.46724836
18	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.25331276
19	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.24026211
20	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.16343253
21	VDR_23849224_ChIP-Seq_CD4+_Human	2.08426486
22	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.01756017
23	ELK1_19687146_ChIP-ChIP_HELA_Human	1.85632603
24	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.81198767
25	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.80761607
26	AR_21572438_ChIP-Seq_LNCaP_Human	1.75607557
27	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.71646600
28	FOXP3_21729870_ChIP-Seq_TREG_Human	1.64253131
29	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.60589666
30	TAF15_26573619_Chip-Seq_HEK293_Human	1.44782197
31	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.43740525
32	IRF1_19129219_ChIP-ChIP_H3396_Human	1.41670091
33	TP53_22573176_ChIP-Seq_HFKS_Human	1.41079403
34	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.33588619
35	ZNF263_19887448_ChIP-Seq_K562_Human	1.32588691
36	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.30104110
37	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.30082463
38	GABP_19822575_ChIP-Seq_HepG2_Human	1.27472768
39	BCAT_22108803_ChIP-Seq_LS180_Human	1.26886163
40	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.25790833
41	GATA3_26560356_Chip-Seq_TH1_Human	1.23572436
42	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.19149696
43	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.18603814
44	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.15615287
45	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.14478467
46	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.14180253
47	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.13942668
48	DCP1A_22483619_ChIP-Seq_HELA_Human	1.13553682
49	FUS_26573619_Chip-Seq_HEK293_Human	1.10366028
50	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.09976433
51	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.06619947
52	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.06619947
53	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.06399411
54	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.06399411
55	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.04326122
56	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.02524685
57	P300_19829295_ChIP-Seq_ESCs_Human	1.01679702
58	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.00148414
59	AR_20517297_ChIP-Seq_VCAP_Human	0.98704629
60	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	0.98684674
61	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.98216331
62	SRY_22984422_ChIP-ChIP_TESTIS_Rat	0.98023882
63	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.95001392
64	MYC_18940864_ChIP-ChIP_HL60_Human	0.93119908
65	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.91725319
66	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.91468441
67	NANOG_19829295_ChIP-Seq_ESCs_Human	0.91340031
68	SOX2_19829295_ChIP-Seq_ESCs_Human	0.91340031
69	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.90113901
70	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.88443323
71	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.84608825
72	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.83273944
73	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.82474048
74	GBX2_23144817_ChIP-Seq_PC3_Human	0.82212448
75	ERG_20517297_ChIP-Seq_VCAP_Human	0.82078665
76	TTF2_22483619_ChIP-Seq_HELA_Human	0.81302279
77	TCF4_22108803_ChIP-Seq_LS180_Human	0.81030893
78	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.80516684
79	NANOG_20526341_ChIP-Seq_ESCs_Human	0.79399362
80	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.79136806
81	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.78692070
82	CBP_20019798_ChIP-Seq_JUKART_Human	0.78692070
83	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.78359799
84	NCOR_22424771_ChIP-Seq_293T_Human	0.78170629
85	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.77914857
86	IGF1R_20145208_ChIP-Seq_DFB_Human	0.77846382
87	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.76289785
88	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.76182580
89	EWS_26573619_Chip-Seq_HEK293_Human	0.76161192
90	ZIC3_20872845_ChIP-ChIP_MESCs_Mouse	0.74833995
91	RXR_22108803_ChIP-Seq_LS180_Human	0.74663150
92	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.72610788
93	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.72582022
94	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.72197070
95	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.72139045
96	STAT3_1855785_ChIP-Seq_MESCs_Mouse	0.72044011
97	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.71848598
98	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.70506162
99	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.70181141
100	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.69860203

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000566_synostosis	9.41257325
2	MP0003303_peritoneal_inflammation	6.99468818
3	MP0006082_CNS_inflammation	5.10934575
4	MP0001663_abnormal_digestive_system	2.72007812
5	MP0001664_abnormal_digestion	2.56977352
6	MP0002751_abnormal_autonomic_nervous	2.52505647
7	MP0002102_abnormal_ear_morphology	2.49580016
8	MP0002876_abnormal_thyroid_physiology	2.44693052
9	MP0001919_abnormal_reproductive_system	2.42312921
10	MP0000467_abnormal_esophagus_morphology	2.18767600
11	MP0000383_abnormal_hair_follicle	2.08356691
12	MP0005381_digestive/alimentary_phenotyp	1.93311943
13	MP0008058_abnormal_DNA_repair	1.88177363
14	MP0005671_abnormal_response_to	1.76125403
15	MP0005389_reproductive_system_phenotype	1.71975345
16	MP0008875_abnormal_xenobiotic_pharmacok	1.57364543
17	MP0002163_abnormal_gland_morphology	1.54636041
18	MP0001986_abnormal_taste_sensitivity	1.54414184
19	MP0004147_increased_porphyrin_level	1.50014202
20	MP0003763_abnormal_thymus_physiology	1.49292616
21	MP0005166_decreased_susceptibility_to	1.49264484
22	MP0001764_abnormal_homeostasis	1.41084299
23	MP0001293_anophthalmia	1.39350070
24	MP0003195_calcinosis	1.38385507
25	MP0006072_abnormal_retinal_apoptosis	1.34996769
26	MP0008877_abnormal_DNA_methylation	1.34281360
27	MP0005253_abnormal_eye_physiology	1.31822548
28	MP0002736_abnormal_nociception_after	1.31599048
29	MP0003115_abnormal_respiratory_system	1.30754585
30	MP0003937_abnormal_limbs/digits/tail_de	1.28453680
31	MP0005084_abnormal_gallbladder_morpholo	1.27770217
32	MP0008872_abnormal_physiological_respon	1.26367353
33	MP0010155_abnormal_intestine_physiology	1.14325888
34	MP0009785_altered_susceptibility_to	1.12723478
35	MP0000490_abnormal_crypts_of	1.12081378
36	MP0003011_delayed_dark_adaptation	1.11161816
37	MP0001529_abnormal_vocalization	1.10879235
38	MP0010678_abnormal_skin_adnexa	1.09449726
39	MP0000372_irregular_coat_pigmentation	1.07834791
40	MP0003718_maternal_effect	1.07300470
41	MP0001968_abnormal_touch/_nociception	1.04549987
42	MP0002138_abnormal_hepatobiliary_system	1.03352886
43	MP0005387_immune_system_phenotype	1.03313249
44	MP0001790_abnormal_immune_system	1.03313249
45	MP0002019_abnormal_tumor_incidence	1.02732688
46	MP0000358_abnormal_cell_content/	0.97736643
47	MP0002405_respiratory_system_inflammati	0.96372457
48	MP0004145_abnormal_muscle_electrophysio	0.94550643
49	MP0005379_endocrine/exocrine_gland_phen	0.94526320
50	MP0001286_abnormal_eye_development	0.91739917
51	MP0005645_abnormal_hypothalamus_physiol	0.90799957
52	MP0002234_abnormal_pharynx_morphology	0.85133934
53	MP0005551_abnormal_eye_electrophysiolog	0.84904469
54	MP0002210_abnormal_sex_determination	0.84463558
55	MP0005501_abnormal_skin_physiology	0.82364980
56	MP0009763_increased_sensitivity_to	0.82037531
57	MP0001800_abnormal_humoral_immune	0.80825578
58	MP0003806_abnormal_nucleotide_metabolis	0.78924020
59	MP0006276_abnormal_autonomic_nervous	0.78921019
60	MP0001915_intracranial_hemorrhage	0.77201818
61	MP0001873_stomach_inflammation	0.76536416
62	MP0005410_abnormal_fertilization	0.75790070
63	MP0000026_abnormal_inner_ear	0.74545759
64	MP0009333_abnormal_splenocyte_physiolog	0.74090184
65	MP0003077_abnormal_cell_cycle	0.73715377
66	MP0005000_abnormal_immune_tolerance	0.73235489
67	MP0003878_abnormal_ear_physiology	0.73216137
68	MP0005377_hearing/vestibular/ear_phenot	0.73216137
69	MP0002837_dystrophic_cardiac_calcinosis	0.73211729
70	MP0002148_abnormal_hypersensitivity_rea	0.72595521
71	MP0005025_abnormal_response_to	0.71966982
72	MP0003693_abnormal_embryo_hatching	0.71879342
73	MP0001348_abnormal_lacrimal_gland	0.71076227
74	MP0008789_abnormal_olfactory_epithelium	0.69157061
75	MP0001963_abnormal_hearing_physiology	0.69062888
76	MP0006292_abnormal_olfactory_placode	0.67670966
77	MP0002452_abnormal_antigen_presenting	0.67548545
78	MP0001905_abnormal_dopamine_level	0.65121742
79	MP0005332_abnormal_amino_acid	0.64551714
80	MP0002109_abnormal_limb_morphology	0.63933528
81	MP0002420_abnormal_adaptive_immunity	0.63757651
82	MP0001819_abnormal_immune_cell	0.63212246
83	MP0009697_abnormal_copulation	0.61366839
84	MP0002653_abnormal_ependyma_morphology	0.60418510
85	MP0005395_other_phenotype	0.60178370
86	MP0000477_abnormal_intestine_morphology	0.60132269
87	MP0002184_abnormal_innervation	0.59826715
88	MP0002277_abnormal_respiratory_mucosa	0.59195412
89	MP0010094_abnormal_chromosome_stability	0.59156877
90	MP0001835_abnormal_antigen_presentation	0.58678635
91	MP0005391_vision/eye_phenotype	0.57213346
92	MP0004885_abnormal_endolymph	0.57123929
93	MP0010368_abnormal_lymphatic_system	0.56963743
94	MP0003786_premature_aging	0.56849805
95	MP0001929_abnormal_gametogenesis	0.56592766
96	MP0005423_abnormal_somatic_nervous	0.56280066
97	MP0003866_abnormal_defecation	0.55391097
98	MP0001119_abnormal_female_reproductive	0.54656267
99	MP0010386_abnormal_urinary_bladder	0.54427767
100	MP0005085_abnormal_gallbladder_physiolo	0.54382942

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	8.27214120
2	Duplicated collecting system (HP:0000081)	6.68280506
3	Abnormality of the renal collecting system (HP:0004742)	6.05199754
4	Large for gestational age (HP:0001520)	5.69741474
5	Long foot (HP:0001833)	5.02640821
6	Adactyly (HP:0009776)	4.97658966
7	Abnormality of fatty-acid metabolism (HP:0004359)	4.82984615
8	Hypoplastic pelvis (HP:0008839)	4.41089538
9	Acute lymphatic leukemia (HP:0006721)	4.24693029
10	Dry hair (HP:0011359)	4.09470989
11	Brushfield spots (HP:0001088)	3.83649773
12	Autoamputation (HP:0001218)	3.72940305
13	Progressive muscle weakness (HP:0003323)	3.66922636
14	Ureteral duplication (HP:0000073)	3.62741619
15	Severe muscular hypotonia (HP:0006829)	3.43019249
16	Ureteral stenosis (HP:0000071)	3.41591491
17	Steatorrhea (HP:0002570)	3.40646629
18	Ureteral obstruction (HP:0006000)	3.15156805
19	Acute necrotizing encephalopathy (HP:0006965)	3.07287905
20	Mitochondrial inheritance (HP:0001427)	3.04820524
21	Pulmonary artery stenosis (HP:0004415)	3.04762679
22	Lactic acidosis (HP:0003128)	3.03933276
23	Abnormal auditory evoked potentials (HP:0006958)	2.98575391
24	Increased CSF lactate (HP:0002490)	2.88183442
25	Hypoplastic nipples (HP:0002557)	2.86691047
26	Menstrual irregularities (HP:0000858)	2.81328346
27	Reduced subcutaneous adipose tissue (HP:0003758)	2.80723878
28	Hepatocellular necrosis (HP:0001404)	2.76633491
29	Increased serum lactate (HP:0002151)	2.76119554
30	Anhidrosis (HP:0000970)	2.74653330
31	Acute encephalopathy (HP:0006846)	2.74279464
32	Abnormal mitochondria in muscle tissue (HP:0008316)	2.74165373
33	Clubbing of toes (HP:0100760)	2.73370318
34	Fat malabsorption (HP:0002630)	2.58857428
35	Broad-based gait (HP:0002136)	2.58004828
36	Renal Fanconi syndrome (HP:0001994)	2.57774507
37	Polyneuropathy (HP:0001271)	2.55232021
38	Hepatic necrosis (HP:0002605)	2.53189619
39	Increased hepatocellular lipid droplets (HP:0006565)	2.48247044
40	Epiphyseal stippling (HP:0010655)	2.47771716
41	Polymicrogyria (HP:0002126)	2.44273305
42	Progressive macrocephaly (HP:0004481)	2.44008435
43	Chorioretinal coloboma (HP:0000567)	2.39219885
44	Exercise intolerance (HP:0003546)	2.37306782
45	Lipid accumulation in hepatocytes (HP:0006561)	2.31933772
46	Hypoproteinemia (HP:0003075)	2.29468544
47	CNS demyelination (HP:0007305)	2.27032174
48	Decreased lacrimation (HP:0000633)	2.23059935
49	3-Methylglutaconic aciduria (HP:0003535)	2.22012938
50	Decreased muscle mass (HP:0003199)	2.21357953
51	Palmoplantar hyperkeratosis (HP:0000972)	2.19500612
52	Rhabdomyolysis (HP:0003201)	2.18040152
53	Palmar hyperkeratosis (HP:0010765)	2.17193505
54	IgG deficiency (HP:0004315)	2.16771981
55	Pancreatic cysts (HP:0001737)	2.12335526
56	Sudden death (HP:0001699)	2.11407454
57	Myoglobinuria (HP:0002913)	2.11027724
58	Respiratory failure (HP:0002878)	2.08086248
59	True hermaphroditism (HP:0010459)	2.01919614
60	Cerebral edema (HP:0002181)	1.98467516
61	Abnormality of B cell number (HP:0010975)	1.96492506
62	Wide intermamillary distance (HP:0006610)	1.96178886
63	Elevated erythrocyte sedimentation rate (HP:0003565)	1.95756932
64	Aplastic anemia (HP:0001915)	1.89832755
65	Abnormality of vision evoked potentials (HP:0000649)	1.89584061
66	Female pseudohermaphroditism (HP:0010458)	1.87267056
67	Increased number of teeth (HP:0011069)	1.85780225
68	Pancreatic fibrosis (HP:0100732)	1.84670946
69	Degeneration of anterior horn cells (HP:0002398)	1.84054201
70	Abnormality of the anterior horn cell (HP:0006802)	1.84054201
71	Overfolded helix (HP:0000396)	1.83592398
72	Optic disc pallor (HP:0000543)	1.82517484
73	Congenital stationary night blindness (HP:0007642)	1.81667719
74	Abnormality of midbrain morphology (HP:0002418)	1.78463378
75	Molar tooth sign on MRI (HP:0002419)	1.78463378
76	B lymphocytopenia (HP:0010976)	1.77437730
77	Transposition of the great arteries (HP:0001669)	1.76443271
78	Abnormal connection of the cardiac segments (HP:0011545)	1.76443271
79	Abnormal ventriculo-arterial connection (HP:0011563)	1.76443271
80	Absent/shortened dynein arms (HP:0200106)	1.75823531
81	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.75823531
82	Abolished electroretinogram (ERG) (HP:0000550)	1.75095451
83	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.74980108
84	Type 2 muscle fiber atrophy (HP:0003554)	1.74805296
85	Exertional dyspnea (HP:0002875)	1.73528914
86	Abnormal respiratory motile cilium morphology (HP:0005938)	1.71743221
87	Abnormal respiratory epithelium morphology (HP:0012253)	1.71743221
88	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.71734971
89	Abnormality of alanine metabolism (HP:0010916)	1.71734971
90	Hyperalaninemia (HP:0003348)	1.71734971
91	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.70591285
92	Plantar hyperkeratosis (HP:0007556)	1.69712979
93	Stomatitis (HP:0010280)	1.69217659
94	Abnormality of the renal cortex (HP:0011035)	1.68640377
95	Metabolic acidosis (HP:0001942)	1.66859698
96	Abnormality of the labia minora (HP:0012880)	1.66758264
97	Medial flaring of the eyebrow (HP:0010747)	1.66009987
98	Severe combined immunodeficiency (HP:0004430)	1.63916540
99	Abnormal epiphyseal ossification (HP:0010656)	1.63904991
100	Broad nasal tip (HP:0000455)	1.62262935

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MKNK1	6.31114185
2	TAOK2	4.74431441
3	TAOK1	4.49728185
4	MAP3K11	3.43998697
5	MAP3K3	3.25494629
6	MAP2K3	3.02418773
7	JAK3	2.14117750
8	MKNK2	10.3639316
9	SRPK1	1.72943609
10	ABL2	1.63538639
11	TIE1	1.48779077
12	DYRK1A	1.48136482
13	VRK2	1.46884925
14	TXK	1.31576973
15	MAP3K5	1.21823752
16	TSSK6	1.19082221
17	BCR	1.17444509
18	TLK1	1.16405226
19	MAP4K2	1.16046618
20	TRIM28	1.08614613
21	ZAK	1.08392071
22	ADRBK2	0.98364695
23	VRK1	0.92995932
24	BCKDK	0.88850805
25	NUAK1	0.88553829
26	BUB1	0.85563314
27	NEK1	0.84955432
28	CHEK2	0.78889648
29	GRK1	0.71780976
30	MST4	0.68714791
31	EIF2AK3	0.64454400
32	PRKCQ	0.64329154
33	CSNK1G3	0.63351582
34	KDR	0.62531660
35	WNK3	0.57669950
36	PLK3	0.57074280
37	TEC	0.53546356
38	CSNK1G1	0.53205029
39	TAF1	0.52866011
40	PLK4	0.51560381
41	WNK4	0.49151750
42	TESK2	0.49073897
43	CSNK1A1L	0.48433391
44	BMPR1B	0.48053300
45	MAP3K8	0.47589875
46	OXSR1	0.47072587
47	TAOK3	0.46837271
48	CSNK1G2	0.45058445
49	STK16	0.44102852
50	MAP3K1	0.42486568
51	NME1	0.38867175
52	ITK	0.37575141
53	PLK2	0.36850677
54	CSNK1A1	0.36090870
55	FRK	0.32631732
56	FES	0.31969222
57	PBK	0.31346261
58	PHKG2	0.31139539
59	PHKG1	0.31139539
60	TESK1	0.29550993
61	GRK7	0.28686893
62	INSRR	0.28532893
63	EIF2AK2	0.28090635
64	MAP2K6	0.27405141
65	IGF1R	0.26752989
66	MAPKAPK3	0.26625948
67	MAP4K1	0.26435767
68	EIF2AK1	0.25073123
69	STK39	0.24148662
70	PINK1	0.23096210
71	GRK5	0.21489261
72	ERBB3	0.19725554
73	CSNK2A1	0.18691907
74	MAP2K7	0.18124693
75	DYRK2	0.17414932
76	TGFBR2	0.17270857
77	MAPK13	0.17075133
78	TGFBR1	0.16887064
79	MAP3K4	0.16502486
80	DAPK1	0.16479718
81	CAMKK2	0.16161829
82	CSNK2A2	0.14524172
83	LIMK1	0.14301520
84	ABL1	0.13553846
85	OBSCN	0.13156314
86	SIK3	0.11867169
87	KIT	0.11713697
88	TNIK	0.11667169
89	ADRBK1	0.11605612
90	MINK1	0.11533823
91	AURKA	0.11358191
92	SYK	0.11173583
93	PTK2B	0.10876705
94	PRKCE	0.09769084
95	PRKCA	0.08631732
96	PRKCD	0.08479131
97	WEE1	0.08369923
98	PRKCG	0.07141330
99	FLT3	0.07025294
100	PAK3	0.06840823

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	4.89818042
2	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	4.72946009
3	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	3.97150211
4	RNA polymerase_Homo sapiens_hsa03020	3.61458581
5	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.23062127
6	Protein export_Homo sapiens_hsa03060	2.55160582
7	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.50646695
8	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.11698484
9	Propanoate metabolism_Homo sapiens_hsa00640	2.11158873
10	One carbon pool by folate_Homo sapiens_hsa00670	2.10457150
11	Oxidative phosphorylation_Homo sapiens_hsa00190	2.08873088
12	Fatty acid elongation_Homo sapiens_hsa00062	2.04224666
13	Butanoate metabolism_Homo sapiens_hsa00650	1.89834416
14	Primary immunodeficiency_Homo sapiens_hsa05340	1.74738757
15	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.71802863
16	Parkinsons disease_Homo sapiens_hsa05012	1.71333158
17	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.65068560
18	Taste transduction_Homo sapiens_hsa04742	1.56548636
19	Pyrimidine metabolism_Homo sapiens_hsa00240	1.45707932
20	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.43534467
21	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.40728685
22	Tryptophan metabolism_Homo sapiens_hsa00380	1.36682337
23	Peroxisome_Homo sapiens_hsa04146	1.29434005
24	Huntingtons disease_Homo sapiens_hsa05016	1.27678779
25	beta-Alanine metabolism_Homo sapiens_hsa00410	1.26940900
26	Phototransduction_Homo sapiens_hsa04744	1.19683218
27	Caffeine metabolism_Homo sapiens_hsa00232	1.18473184
28	RNA transport_Homo sapiens_hsa03013	1.17065050
29	Nucleotide excision repair_Homo sapiens_hsa03420	1.16653748
30	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.15226938
31	Purine metabolism_Homo sapiens_hsa00230	1.12878227
32	Allograft rejection_Homo sapiens_hsa05330	1.12755539
33	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.08329180
34	Asthma_Homo sapiens_hsa05310	1.07805449
35	Homologous recombination_Homo sapiens_hsa03440	1.02732339
36	Graft-versus-host disease_Homo sapiens_hsa05332	0.99972145
37	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.99270554
38	Basal transcription factors_Homo sapiens_hsa03022	0.96942265
39	Alzheimers disease_Homo sapiens_hsa05010	0.93292697
40	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.91877012
41	Nitrogen metabolism_Homo sapiens_hsa00910	0.88170442
42	Steroid biosynthesis_Homo sapiens_hsa00100	0.87499494
43	Mismatch repair_Homo sapiens_hsa03430	0.84051614
44	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.83378364
45	Glycerolipid metabolism_Homo sapiens_hsa00561	0.82573201
46	Type I diabetes mellitus_Homo sapiens_hsa04940	0.82466872
47	RNA degradation_Homo sapiens_hsa03018	0.80794232
48	Ribosome_Homo sapiens_hsa03010	0.79336496
49	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.79017786
50	Selenocompound metabolism_Homo sapiens_hsa00450	0.78898560
51	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.75979502
52	Antigen processing and presentation_Homo sapiens_hsa04612	0.75445869
53	Linoleic acid metabolism_Homo sapiens_hsa00591	0.72605333
54	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.71530497
55	Fanconi anemia pathway_Homo sapiens_hsa03460	0.71299205
56	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.70944436
57	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.68476580
58	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.68013281
59	Fatty acid degradation_Homo sapiens_hsa00071	0.67204199
60	Carbon metabolism_Homo sapiens_hsa01200	0.67054040
61	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.66086141
62	DNA replication_Homo sapiens_hsa03030	0.65350995
63	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.64312028
64	Lysine degradation_Homo sapiens_hsa00310	0.62434431
65	Metabolic pathways_Homo sapiens_hsa01100	0.61703352
66	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.58289317
67	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.58230184
68	Fatty acid metabolism_Homo sapiens_hsa01212	0.57610329
69	Rheumatoid arthritis_Homo sapiens_hsa05323	0.57278787
70	Non-homologous end-joining_Homo sapiens_hsa03450	0.56949236
71	Collecting duct acid secretion_Homo sapiens_hsa04966	0.56857677
72	Chemical carcinogenesis_Homo sapiens_hsa05204	0.56758225
73	Base excision repair_Homo sapiens_hsa03410	0.55309569
74	Viral myocarditis_Homo sapiens_hsa05416	0.53644081
75	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.50624436
76	Retinol metabolism_Homo sapiens_hsa00830	0.49526232
77	Cardiac muscle contraction_Homo sapiens_hsa04260	0.48025624
78	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.47359623
79	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.46098595
80	Olfactory transduction_Homo sapiens_hsa04740	0.45855203
81	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.45806195
82	Sulfur metabolism_Homo sapiens_hsa00920	0.45355298
83	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.43087519
84	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.42547611
85	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.42256243
86	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.41717239
87	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.41256931
88	Glutathione metabolism_Homo sapiens_hsa00480	0.40772749
89	Pyruvate metabolism_Homo sapiens_hsa00620	0.40297389
90	Spliceosome_Homo sapiens_hsa03040	0.37739671
91	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.37553871
92	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.37050420
93	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.36827811
94	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.36623587
95	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.35526556
96	Fat digestion and absorption_Homo sapiens_hsa04975	0.33975903
97	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.32367155
98	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.31667396
99	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.29465395
100	Nicotine addiction_Homo sapiens_hsa05033	0.29296225

GAPDHP38

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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