ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	negative regulation of T cell receptor signaling pathway (GO:0050860)	9.92276909
2	eosinophil migration (GO:0072677)	9.50691654
3	regulation of sister chromatid cohesion (GO:0007063)	8.76374451
4	regulation of mononuclear cell migration (GO:0071675)	8.73508113
5	negative regulation of peptidyl-threonine phosphorylation (GO:0010801)	8.72173156
6	L-fucose catabolic process (GO:0042355)	8.09870627
7	fucose catabolic process (GO:0019317)	8.09870627
8	L-fucose metabolic process (GO:0042354)	8.09870627
9	negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)	7.77765454
10	ribosomal small subunit assembly (GO:0000028)	7.76271654
11	branch elongation of an epithelium (GO:0060602)	7.68791647
12	vesicle fusion (GO:0006906)	7.47743234
13	negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)	7.30705357
14	positive regulation of chromosome segregation (GO:0051984)	7.10582193
15	peptidyl-lysine dimethylation (GO:0018027)	6.89755547
16	autophagic vacuole fusion (GO:0000046)	6.76218039
17	coenzyme A biosynthetic process (GO:0015937)	6.61400354
18	macrophage chemotaxis (GO:0048246)	6.43872596
19	organ growth (GO:0035265)	5.96003107
20	regulation of T cell receptor signaling pathway (GO:0050856)	5.88061390
21	localization within membrane (GO:0051668)	5.79360136
22	axis elongation (GO:0003401)	5.68510188
23	negative regulation of GTP catabolic process (GO:0033125)	5.66641171
24	negative regulation of GTPase activity (GO:0034260)	5.66641171
25	positive regulation of calcium ion import (GO:0090280)	5.64823629
26	regulation of nitric-oxide synthase biosynthetic process (GO:0051769)	5.62811642
27	establishment of mitotic spindle orientation (GO:0000132)	5.62464989
28	regulation of beta-amyloid formation (GO:1902003)	5.52838826
29	organelle membrane fusion (GO:0090174)	5.51845041
30	acrosome assembly (GO:0001675)	5.28719139
31	protein import into peroxisome matrix (GO:0016558)	5.24004915
32	monocyte chemotaxis (GO:0002548)	5.23996445
33	non-recombinational repair (GO:0000726)	4.94050485
34	double-strand break repair via nonhomologous end joining (GO:0006303)	4.94050485
35	establishment of mitotic spindle localization (GO:0040001)	4.90105659
36	protein targeting to vacuole (GO:0006623)	4.86586364
37	protein targeting to lysosome (GO:0006622)	4.86586364
38	establishment of protein localization to vacuole (GO:0072666)	4.86586364
39	establishment of spindle orientation (GO:0051294)	4.79069803
40	oxidative demethylation (GO:0070989)	4.78200695
41	detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)	4.70729894
42	negative regulation of circadian rhythm (GO:0042754)	4.69419075
43	3-UTR-mediated mRNA stabilization (GO:0070935)	4.59067363
44	organelle fusion (GO:0048284)	4.56021685
45	histone H3-K9 methylation (GO:0051567)	4.51221438
46	regulation of stem cell maintenance (GO:2000036)	4.49758953
47	pantothenate metabolic process (GO:0015939)	4.49616223
48	fucosylation (GO:0036065)	4.41914055
49	regulation of amyloid precursor protein catabolic process (GO:1902991)	4.41208072
50	positive chemotaxis (GO:0050918)	4.40481350
51	seminiferous tubule development (GO:0072520)	4.39214323
52	fucose metabolic process (GO:0006004)	4.30884915
53	regulation of antigen receptor-mediated signaling pathway (GO:0050854)	4.30535136
54	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	4.26187458
55	regulation of autophagic vacuole assembly (GO:2000785)	4.18968042
56	ribonucleoside bisphosphate biosynthetic process (GO:0034030)	4.10881090
57	nucleoside bisphosphate biosynthetic process (GO:0033866)	4.10881090
58	purine nucleoside bisphosphate biosynthetic process (GO:0034033)	4.10881090
59	detection of chemical stimulus involved in sensory perception of taste (GO:0050912)	4.08029533
60	positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)	4.00484483
61	coenzyme A metabolic process (GO:0015936)	3.95763413
62	preassembly of GPI anchor in ER membrane (GO:0016254)	3.86099547
63	mitochondrial RNA metabolic process (GO:0000959)	3.85774982
64	single-organism membrane fusion (GO:0044801)	3.81981908
65	negative regulation of purine nucleotide catabolic process (GO:0033122)	3.80382219
66	regulation of fibroblast growth factor receptor signaling pathway (GO:0040036)	3.77327825
67	protein localization to lysosome (GO:0061462)	3.75535114
68	protein localization to vacuole (GO:0072665)	3.75535114
69	folic acid-containing compound biosynthetic process (GO:0009396)	3.70438862
70	histone H3-K9 modification (GO:0061647)	3.69676965
71	ER to Golgi vesicle-mediated transport (GO:0006888)	3.66309700
72	negative regulation of nucleoside metabolic process (GO:0045978)	3.64690068
73	negative regulation of nucleotide catabolic process (GO:0030812)	3.59722095
74	vesicle targeting (GO:0006903)	3.47463425
75	negative regulation of macroautophagy (GO:0016242)	3.47263482
76	regulation of vacuole organization (GO:0044088)	3.44040357
77	DNA integration (GO:0015074)	3.43794153
78	COPII vesicle coating (GO:0048208)	3.42506597
79	regulation of mammary gland epithelial cell proliferation (GO:0033599)	3.41529206
80	regulation of cellular amide metabolic process (GO:0034248)	3.41436189
81	establishment of spindle localization (GO:0051293)	3.41276057
82	protein targeting to peroxisome (GO:0006625)	3.41205581
83	establishment of protein localization to peroxisome (GO:0072663)	3.41205581
84	protein localization to peroxisome (GO:0072662)	3.41205581
85	DNA demethylation (GO:0080111)	3.38601901
86	regulation of calcium ion import (GO:0090279)	3.36509390
87	sodium-independent organic anion transport (GO:0043252)	3.34697986
88	membrane budding (GO:0006900)	3.30518758
89	proteasome assembly (GO:0043248)	3.30513384
90	peroxisomal transport (GO:0043574)	3.28851822
91	regulation of peptidyl-threonine phosphorylation (GO:0010799)	3.24403590
92	imidazole-containing compound metabolic process (GO:0052803)	3.21157672
93	early endosome to late endosome transport (GO:0045022)	3.20559304
94	negative regulation of Ras GTPase activity (GO:0034261)	12.3799359
95	protein prenylation (GO:0018342)	12.2603047
96	prenylation (GO:0097354)	12.2603047
97	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	11.4091837
98	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	11.4091837
99	positive regulation of mitotic sister chromatid separation (GO:1901970)	11.4091837
100	eosinophil chemotaxis (GO:0048245)	10.4906568

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	VDR_22108803_ChIP-Seq_LS180_Human	6.18102570
2	NOTCH1_21737748_ChIP-Seq_TLL_Human	4.31671518
3	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	4.17807772
4	AR_21572438_ChIP-Seq_LNCaP_Human	2.99438988
5	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.65952760
6	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.57018592
7	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.55599841
8	ZNF263_19887448_ChIP-Seq_K562_Human	2.45854523
9	SRY_22984422_ChIP-ChIP_TESTIS_Rat	2.31053450
10	YY1_21170310_ChIP-Seq_MESCs_Mouse	2.09227436
11	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.08462147
12	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	10.5082144
13	GATA1_22025678_ChIP-Seq_K562_Human	10.2329879
14	ZIC3_20872845_ChIP-ChIP_MESCs_Mouse	1.94807485
15	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.81448116
16	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.81361574
17	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.74650617
18	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.71418679
19	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.71418679
20	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.66541380
21	BCAT_22108803_ChIP-Seq_LS180_Human	1.64911699
22	IRF1_19129219_ChIP-ChIP_H3396_Human	1.63187317
23	RXR_22108803_ChIP-Seq_LS180_Human	1.58466972
24	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.50787845
25	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.44697850
26	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.43981743
27	GATA3_26560356_Chip-Seq_TH1_Human	1.43681002
28	TAF15_26573619_Chip-Seq_HEK293_Human	1.40849584
29	ZNF274_21170338_ChIP-Seq_K562_Hela	1.38391846
30	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.37488749
31	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.36043395
32	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.34892322
33	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.26477502
34	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.26147168
35	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.24323682
36	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.24323682
37	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.24323682
38	TP53_16413492_ChIP-PET_HCT116_Human	1.23390933
39	GBX2_23144817_ChIP-Seq_PC3_Human	1.15885353
40	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.15406079
41	TP53_22573176_ChIP-Seq_HFKS_Human	1.05999573
42	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.05574278
43	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.03493611
44	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.02763446
45	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.02753012
46	RUNX_20019798_ChIP-Seq_JUKART_Human	1.02648132
47	ETS1_20019798_ChIP-Seq_JURKAT_Human	0.97392326
48	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.96719836
49	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	0.93465918
50	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	0.90441899
51	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.89570732
52	STAT1_20625510_ChIP-Seq_HELA_Human	0.88934368
53	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.88320406
54	FUS_26573619_Chip-Seq_HEK293_Human	0.86492792
55	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.85922160
56	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.85922160
57	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	0.85218053
58	WDR5_24793694_ChIP-Seq_LNCAP_Human	0.84440139
59	TCF4_22108803_ChIP-Seq_LS180_Human	0.79974220
60	CTCF_21964334_Chip-Seq_Bcells_Human	0.78098229
61	P300_19829295_ChIP-Seq_ESCs_Human	0.77070850
62	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.75803738
63	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.74313261
64	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.74303326
65	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.73728640
66	GATA1_19941826_ChIP-Seq_K562_Human	0.72595097
67	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.72590124
68	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	0.72056735
69	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.71995812
70	OCT1_27270436_Chip-Seq_PROSTATE_Human	0.70504379
71	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.70312221
72	NANOG_19829295_ChIP-Seq_ESCs_Human	0.69693116
73	SOX2_19829295_ChIP-Seq_ESCs_Human	0.69693116
74	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	0.68432427
75	GATA3_21867929_ChIP-Seq_TH1_Mouse	0.68093828
76	SOX3_22085726_ChIP-Seq_MUSCLE_Mouse	0.67067415
77	LUZP1_20508642_ChIP-Seq_ESCs_Mouse	0.66071663
78	ERG_20517297_ChIP-Seq_VCAP_Human	0.65080728
79	TBX3_20139965_ChIP-Seq_ESCs_Mouse	0.65066583
80	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	0.64695663
81	TBX3_20139965_ChIP-Seq_MESCs_Mouse	0.64446492
82	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.63143975
83	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.62547735
84	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.61581494
85	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.61559023
86	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.60847258
87	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.60216621
88	VDR_23849224_ChIP-Seq_CD4+_Human	0.59842592
89	CTNNB1_20460455_ChIP-Seq_HCT116_Human	0.59435121
90	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.59342102
91	CBP_20019798_ChIP-Seq_JUKART_Human	0.59342102
92	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.59256346
93	HTT_18923047_ChIP-ChIP_STHdh_Human	0.58677571
94	NANOG_20526341_ChIP-Seq_ESCs_Human	0.58338008
95	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.57966865
96	ELF1_17652178_ChIP-ChIP_JURKAT_Human	0.57390009
97	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.56063795
98	GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse	0.55281440
99	MYC_18555785_ChIP-Seq_MESCs_Mouse	0.55220792
100	CBP_21632823_ChIP-Seq_H3396_Human	0.54433061

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003303_peritoneal_inflammation	9.42810050
2	MP0006082_CNS_inflammation	5.53726540
3	MP0001663_abnormal_digestive_system	3.19552285
4	MP0000467_abnormal_esophagus_morphology	3.00522651
5	MP0001664_abnormal_digestion	2.98252349
6	MP0001919_abnormal_reproductive_system	2.74242390
7	MP0000383_abnormal_hair_follicle	2.51606469
8	MP0002751_abnormal_autonomic_nervous	2.36156405
9	MP0005381_digestive/alimentary_phenotyp	2.36047254
10	MP0003115_abnormal_respiratory_system	2.28970036
11	MP0000566_synostosis	12.5723426
12	MP0002876_abnormal_thyroid_physiology	1.99963945
13	MP0005389_reproductive_system_phenotype	1.69748849
14	MP0005166_decreased_susceptibility_to	1.67057653
15	MP0010678_abnormal_skin_adnexa	1.61782902
16	MP0000534_abnormal_ureter_morphology	1.56159261
17	MP0003937_abnormal_limbs/digits/tail_de	1.53389789
18	MP0003136_yellow_coat_color	1.27676750
19	MP0001915_intracranial_hemorrhage	1.21453893
20	MP0005076_abnormal_cell_differentiation	1.19298959
21	MP0000428_abnormal_craniofacial_morphol	1.14071848
22	MP0001764_abnormal_homeostasis	1.13630738
23	MP0003453_abnormal_keratinocyte_physiol	1.10596307
24	MP0001293_anophthalmia	1.06344544
25	MP0003763_abnormal_thymus_physiology	1.06284828
26	MP0005397_hematopoietic_system_phenotyp	1.03870152
27	MP0001545_abnormal_hematopoietic_system	1.03870152
28	MP0001286_abnormal_eye_development	1.03480017
29	MP0000858_altered_metastatic_potential	0.99363287
30	MP0005501_abnormal_skin_physiology	0.99301570
31	MP0002019_abnormal_tumor_incidence	0.93244493
32	MP0002138_abnormal_hepatobiliary_system	0.87023586
33	MP0000026_abnormal_inner_ear	0.86542013
34	MP0002109_abnormal_limb_morphology	0.86512555
35	MP0001963_abnormal_hearing_physiology	0.85671928
36	MP0005360_urolithiasis	0.83310099
37	MP0005646_abnormal_pituitary_gland	0.81927579
38	MP0002938_white_spotting	0.81625012
39	MP0002638_abnormal_pupillary_reflex	0.77433174
40	MP0000358_abnormal_cell_content/	0.76945887
41	MP0008995_early_reproductive_senescence	0.76731727
42	MP0002405_respiratory_system_inflammati	0.76529176
43	MP0005253_abnormal_eye_physiology	0.76390411
44	MP0002115_abnormal_skeleton_extremities	0.75984695
45	MP0000490_abnormal_crypts_of	0.75948190
46	MP0009763_increased_sensitivity_to	0.74990670
47	MP0004885_abnormal_endolymph	0.74627524
48	MP0004381_abnormal_hair_follicle	0.72821704
49	MP0003195_calcinosis	0.72548898
50	MP0005075_abnormal_melanosome_morpholog	0.72548044
51	MP0010155_abnormal_intestine_physiology	0.72485882
52	MP0002736_abnormal_nociception_after	0.71162399
53	MP0000470_abnormal_stomach_morphology	0.70010966
54	MP0003329_amyloid_beta_deposits	0.68780517
55	MP0003942_abnormal_urinary_system	0.68606716
56	MP0002210_abnormal_sex_determination	0.65668034
57	MP0005197_abnormal_uvea_morphology	0.65528092
58	MP0002184_abnormal_innervation	0.65407839
59	MP0008872_abnormal_physiological_respon	0.57336191
60	MP0005332_abnormal_amino_acid	0.55851182
61	MP0003724_increased_susceptibility_to	0.53542526
62	MP0008058_abnormal_DNA_repair	0.53248115
63	MP0002735_abnormal_chemical_nociception	0.52261303
64	MP0005551_abnormal_eye_electrophysiolog	0.50097367
65	MP0001968_abnormal_touch/_nociception	0.50011625
66	MP0000377_abnormal_hair_follicle	0.48202453
67	MP0004145_abnormal_muscle_electrophysio	0.48149386
68	MP0005025_abnormal_response_to	0.46899619
69	MP0002095_abnormal_skin_pigmentation	0.46615352
70	MP0001800_abnormal_humoral_immune	0.45771591
71	MP0000477_abnormal_intestine_morphology	0.45400878
72	MP0001175_abnormal_lung_morphology	0.43468721
73	MP0005000_abnormal_immune_tolerance	0.43316478
74	MP0002452_abnormal_antigen_presenting	0.42843372
75	MP0000604_amyloidosis	0.42420389
76	MP0000432_abnormal_head_morphology	0.41353172
77	MP0003638_abnormal_response/metabolism_	0.40380153
78	MP0003936_abnormal_reproductive_system	0.40347403
79	MP0002136_abnormal_kidney_physiology	0.40334415
80	MP0005391_vision/eye_phenotype	0.39295248
81	MP0001501_abnormal_sleep_pattern	0.39261591
82	MP0000627_abnormal_mammary_gland	0.38606826
83	MP0005508_abnormal_skeleton_morphology	0.38370748
84	MP0006276_abnormal_autonomic_nervous	0.38159184
85	MP0000681_abnormal_thyroid_gland	0.36863599
86	MP0002163_abnormal_gland_morphology	0.36770640
87	MP0008875_abnormal_xenobiotic_pharmacok	0.34832161
88	MP0005671_abnormal_response_to	0.33892757
89	MP0003935_abnormal_craniofacial_develop	0.33743195
90	MP0003646_muscle_fatigue	0.32959431
91	MP0005023_abnormal_wound_healing	0.32889791
92	MP0004147_increased_porphyrin_level	0.32864010
93	MP0002752_abnormal_somatic_nervous	0.32821600
94	MP0000013_abnormal_adipose_tissue	0.32712653
95	MP0002113_abnormal_skeleton_development	0.32003594
96	MP0002837_dystrophic_cardiac_calcinosis	0.31991051
97	MP0003880_abnormal_central_pattern	0.31863768
98	MP0003011_delayed_dark_adaptation	0.31257964
99	MP0009672_abnormal_birth_weight	0.30403251
100	MP0001502_abnormal_circadian_rhythm	0.29363847

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Duplicated collecting system (HP:0000081)	9.36619402
2	Abnormality of the renal collecting system (HP:0004742)	8.44212280
3	Long foot (HP:0001833)	8.01008540
4	Large for gestational age (HP:0001520)	7.47318841
5	Adactyly (HP:0009776)	6.68015973
6	Acute lymphatic leukemia (HP:0006721)	6.60299536
7	Progressive muscle weakness (HP:0003323)	6.13628960
8	Abnormality of fatty-acid metabolism (HP:0004359)	6.01181882
9	Hypoplastic pelvis (HP:0008839)	5.90491043
10	Dry hair (HP:0011359)	5.31236582
11	Autoamputation (HP:0001218)	5.26709358
12	Ureteral stenosis (HP:0000071)	4.91203443
13	Pulmonary artery stenosis (HP:0004415)	4.90064726
14	Brushfield spots (HP:0001088)	4.80261030
15	Steatorrhea (HP:0002570)	4.78750069
16	Ureteral duplication (HP:0000073)	4.74361589
17	Hypoplastic nipples (HP:0002557)	4.64076891
18	Menstrual irregularities (HP:0000858)	4.61246240
19	Ureteral obstruction (HP:0006000)	4.51791186
20	Reduced subcutaneous adipose tissue (HP:0003758)	4.40048599
21	Severe muscular hypotonia (HP:0006829)	4.00920861
22	Abnormal auditory evoked potentials (HP:0006958)	3.96203026
23	Sudden death (HP:0001699)	3.77975953
24	Fat malabsorption (HP:0002630)	3.74463312
25	Broad-based gait (HP:0002136)	3.73740971
26	Increased number of teeth (HP:0011069)	3.66041730
27	Anhidrosis (HP:0000970)	3.65199904
28	Transposition of the great arteries (HP:0001669)	3.57849677
29	Abnormal connection of the cardiac segments (HP:0011545)	3.57849677
30	Abnormal ventriculo-arterial connection (HP:0011563)	3.57849677
31	Decreased lacrimation (HP:0000633)	3.57658198
32	Polyneuropathy (HP:0001271)	3.23318810
33	Palmoplantar hyperkeratosis (HP:0000972)	3.21046805
34	Palmar hyperkeratosis (HP:0010765)	3.02733276
35	Decreased muscle mass (HP:0003199)	3.01349244
36	Abnormality of vision evoked potentials (HP:0000649)	2.95030867
37	Broad nasal tip (HP:0000455)	2.92626636
38	Polymicrogyria (HP:0002126)	2.88974134
39	Wide intermamillary distance (HP:0006610)	2.88016592
40	Clubbing of toes (HP:0100760)	2.84957400
41	Hypoplastic iliac wings (HP:0002866)	2.79305448
42	Myoglobinuria (HP:0002913)	2.72018379
43	Rhabdomyolysis (HP:0003201)	2.59072377
44	Large hands (HP:0001176)	2.53311076
45	Plantar hyperkeratosis (HP:0007556)	2.53009009
46	Chorioretinal coloboma (HP:0000567)	2.51183145
47	Generalized amyotrophy (HP:0003700)	2.47911117
48	Widely spaced teeth (HP:0000687)	2.47177862
49	Steppage gait (HP:0003376)	2.45620387
50	Epiphyseal stippling (HP:0010655)	2.41531349
51	Basal ganglia calcification (HP:0002135)	2.39841733
52	Flat face (HP:0012368)	2.31297697
53	Aplasia/Hypoplasia of the nipples (HP:0006709)	2.28143791
54	Lactic acidosis (HP:0003128)	2.17310842
55	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.16891444
56	Abnormality of alanine metabolism (HP:0010916)	2.16891444
57	Hyperalaninemia (HP:0003348)	2.16891444
58	Female pseudohermaphroditism (HP:0010458)	2.15113561
59	Overfolded helix (HP:0000396)	2.09306718
60	Thickened calvaria (HP:0002684)	2.09047564
61	Purpura (HP:0000979)	2.04779183
62	Anxiety (HP:0000739)	2.03981047
63	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	11.4941292
64	Primary adrenal insufficiency (HP:0008207)	1.98896078
65	Gangrene (HP:0100758)	1.95373227
66	Arterial thrombosis (HP:0004420)	1.92695853
67	Pulmonary embolism (HP:0002204)	1.90924113
68	Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)	1.88177418
69	Prenatal maternal abnormality (HP:0002686)	1.86974616
70	Absent toe (HP:0010760)	1.86224487
71	Abnormally folded helix (HP:0008544)	1.86130967
72	Thickened nuchal skin fold (HP:0000474)	1.84517411
73	Abnormal epiphyseal ossification (HP:0010656)	1.83788538
74	Metabolic acidosis (HP:0001942)	1.82851241
75	Congenital onset (HP:0003577)	1.79947966
76	Posterior embryotoxon (HP:0000627)	1.79368613
77	Constricted visual fields (HP:0001133)	1.79239476
78	External ear malformation (HP:0008572)	1.75811391
79	Spastic tetraplegia (HP:0002510)	1.75444898
80	Foot dorsiflexor weakness (HP:0009027)	1.74756639
81	Congenital sensorineural hearing impairment (HP:0008527)	1.73191972
82	Abnormality of the line of Schwalbe (HP:0008048)	1.71749220
83	Arthrogryposis multiplex congenita (HP:0002804)	1.69649506
84	Stereotypic behavior (HP:0000733)	1.66129358
85	Generalized muscle weakness (HP:0003324)	1.63840402
86	Decreased number of peripheral myelinated nerve fibers (HP:0003380)	1.61805469
87	Hammertoe (HP:0001765)	1.60635327
88	Depressed nasal ridge (HP:0000457)	1.60200700
89	Abnormality of the epiphyses of the hand (HP:0005924)	1.56788522
90	Abnormality of the foot musculature (HP:0001436)	1.56631729
91	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.53088333
92	Abnormality involving the epiphyses of the upper limbs (HP:0003839)	1.46000590
93	Aplasia/Hypoplasia involving the pelvis (HP:0009103)	1.45448616
94	Hypoplastic ilia (HP:0000946)	1.44714114
95	Increased serum lactate (HP:0002151)	1.42278131
96	Retinopathy (HP:0000488)	1.41303168
97	Thrombophlebitis (HP:0004418)	1.40954084
98	Scrotal hypoplasia (HP:0000046)	1.40842765
99	Decreased motor nerve conduction velocity (HP:0003431)	1.38121475
100	Congenital stationary night blindness (HP:0007642)	1.38115289

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MKNK1	6.74398821
2	TAOK2	5.33585681
3	TAOK1	5.18337921
4	MAP3K3	4.36489451
5	MAP2K3	4.18268110
6	MAP3K11	3.85855370
7	JAK3	2.69583640
8	MKNK2	11.4556585
9	ABL2	1.83617144
10	DYRK1A	1.77325317
11	MAP3K5	1.24283477
12	MAP3K1	0.92539855
13	SRPK1	0.91473952
14	CHEK2	0.83288596
15	PRKCQ	0.61181225
16	MAP3K8	0.56953942
17	TIE1	0.39437349
18	TXK	0.37695390
19	GRK1	0.34421572
20	CSNK1A1	0.30491015
21	WNK3	0.28234339
22	MAP4K2	0.25558336
23	TEC	0.25434852
24	ACVR1B	0.24036076
25	ADRBK2	0.23787745
26	MAP4K1	0.21277713
27	ITK	0.19934747
28	FRK	0.17198962
29	ABL1	0.16478641
30	STK16	0.15865565
31	INSRR	0.14664901
32	PDK2	0.14336417
33	OBSCN	0.13991740
34	PIK3CG	0.13101691
35	IGF1R	0.13026276
36	PRKCD	0.12960837
37	NTRK2	0.10552826
38	PRKD3	0.09467708
39	ADRBK1	0.09213219
40	TLK1	0.08856503
41	CSNK2A2	0.08038898
42	PIK3CA	0.07877274
43	CSNK1G1	0.07175601
44	EPHA4	0.07138371
45	BMPR1B	0.06651974
46	WNK4	0.06325762
47	PRKCA	0.05874887
48	CCNB1	0.05504053
49	IKBKB	0.05251138
50	VRK1	0.04742497
51	SYK	0.04479892
52	MAPK13	0.04328644
53	CSNK2A1	0.03870868
54	GRK7	0.03837008
55	NME1	0.03576412
56	CSNK1E	0.03371902
57	MUSK	0.02993137
58	CSNK1G3	0.02438573
59	PRKACA	0.02077479
60	BTK	0.02055513
61	FLT3	0.01299914
62	KIT	0.01009756
63	PRKCB	0.00315088
64	NUAK1	0.00101041
65	CAMK2A	-0.0745924
66	FGR	-0.0711751
67	NTRK3	-0.0708883
68	BMPR2	-0.0671366
69	LCK	-0.0670313
70	ERBB4	-0.0667084
71	MAP3K4	-0.0632641
72	CAMK1	-0.0614514
73	LYN	-0.0610627
74	ZAK	-0.0603603
75	OXSR1	-0.0537930
76	TNIK	-0.0520012
77	CSNK1G2	-0.0489077
78	CAMK2D	-0.0435638
79	TGFBR1	-0.0418944
80	PIM2	-0.0393051
81	CDK9	-0.0381613
82	SRC	-0.0303843
83	IKBKE	-0.0301555
84	AURKA	-0.0291871
85	FES	-0.0265112
86	MAPK15	-0.0240007
87	GRK6	-0.0239950
88	PRKCG	-0.0166742
89	SGK494	-0.0158402
90	SGK223	-0.0158402
91	SGK2	-0.0156332
92	TNK2	-0.0155792
93	TAF1	-0.0148445
94	EPHB2	-0.0115203
95	GRK5	-0.0062333
96	PRKCE	-0.0059920
97	MAPKAPK5	-0.0051596
98	PHKG2	-0.0047149
99	PHKG1	-0.0047149
100	RPS6KB2	-0.0019176

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	7.93910210
2	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	6.39497786
3	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.67359006
4	Taste transduction_Homo sapiens_hsa04742	3.12024291
5	RNA polymerase_Homo sapiens_hsa03020	2.88419063
6	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.74261947
7	Proteasome_Homo sapiens_hsa03050	2.72922077
8	One carbon pool by folate_Homo sapiens_hsa00670	2.67901338
9	Butanoate metabolism_Homo sapiens_hsa00650	2.47114747
10	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	2.28339178
11	Fatty acid elongation_Homo sapiens_hsa00062	2.08633933
12	Lysine degradation_Homo sapiens_hsa00310	2.06361727
13	beta-Alanine metabolism_Homo sapiens_hsa00410	1.90949397
14	Propanoate metabolism_Homo sapiens_hsa00640	1.81811298
15	Tryptophan metabolism_Homo sapiens_hsa00380	1.80077522
16	Glycerolipid metabolism_Homo sapiens_hsa00561	1.76489229
17	Amoebiasis_Homo sapiens_hsa05146	1.35478158
18	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.10460107
19	Peroxisome_Homo sapiens_hsa04146	1.05701043
20	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.02780390
21	Nitrogen metabolism_Homo sapiens_hsa00910	0.94635359
22	Fatty acid degradation_Homo sapiens_hsa00071	0.93030288
23	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.92850837
24	Asthma_Homo sapiens_hsa05310	0.91582586
25	Type I diabetes mellitus_Homo sapiens_hsa04940	0.88991293
26	Allograft rejection_Homo sapiens_hsa05330	0.88118832
27	Linoleic acid metabolism_Homo sapiens_hsa00591	0.82504413
28	Nicotine addiction_Homo sapiens_hsa05033	0.81776465
29	Complement and coagulation cascades_Homo sapiens_hsa04610	0.81731763
30	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.81550401
31	Viral myocarditis_Homo sapiens_hsa05416	0.80433048
32	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.80154322
33	Graft-versus-host disease_Homo sapiens_hsa05332	0.79916673
34	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.79408552
35	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.78471884
36	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.75999741
37	Retinol metabolism_Homo sapiens_hsa00830	0.74808890
38	Caffeine metabolism_Homo sapiens_hsa00232	0.70670483
39	Olfactory transduction_Homo sapiens_hsa04740	0.68506322
40	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.67871495
41	Phototransduction_Homo sapiens_hsa04744	0.67005640
42	Rheumatoid arthritis_Homo sapiens_hsa05323	0.66199049
43	Primary immunodeficiency_Homo sapiens_hsa05340	0.65696246
44	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.65567574
45	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.63996569
46	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.63801921
47	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.63063261
48	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.61237630
49	Cholinergic synapse_Homo sapiens_hsa04725	0.59667478
50	Fatty acid metabolism_Homo sapiens_hsa01212	0.57336462
51	Pyrimidine metabolism_Homo sapiens_hsa00240	0.57110089
52	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.56000031
53	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.55920197
54	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.53524669
55	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.51271668
56	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.50075880
57	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.48788522
58	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.48085667
59	Collecting duct acid secretion_Homo sapiens_hsa04966	0.47737448
60	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.47074166
61	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.46916130
62	Arginine biosynthesis_Homo sapiens_hsa00220	0.46529699
63	AMPK signaling pathway_Homo sapiens_hsa04152	0.43750929
64	Serotonergic synapse_Homo sapiens_hsa04726	0.43462472
65	Chemical carcinogenesis_Homo sapiens_hsa05204	0.41034810
66	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.40378790
67	Nucleotide excision repair_Homo sapiens_hsa03420	0.40276484
68	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.40265185
69	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.39119181
70	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.37768455
71	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.36158746
72	Purine metabolism_Homo sapiens_hsa00230	0.35332205
73	Sulfur metabolism_Homo sapiens_hsa00920	0.34653001
74	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.34651648
75	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.31260975
76	Morphine addiction_Homo sapiens_hsa05032	0.30256896
77	Ether lipid metabolism_Homo sapiens_hsa00565	0.29504206
78	RNA transport_Homo sapiens_hsa03013	0.28592409
79	Metabolic pathways_Homo sapiens_hsa01100	0.28514630
80	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.28466581
81	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.28181254
82	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.26657912
83	Antigen processing and presentation_Homo sapiens_hsa04612	0.26430646
84	Fat digestion and absorption_Homo sapiens_hsa04975	0.26185121
85	TNF signaling pathway_Homo sapiens_hsa04668	0.26074121
86	Choline metabolism in cancer_Homo sapiens_hsa05231	0.24748015
87	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.22526919
88	GABAergic synapse_Homo sapiens_hsa04727	0.19690686
89	GnRH signaling pathway_Homo sapiens_hsa04912	0.18507304
90	Phagosome_Homo sapiens_hsa04145	0.18342696
91	MicroRNAs in cancer_Homo sapiens_hsa05206	0.17454463
92	Salmonella infection_Homo sapiens_hsa05132	0.16225895
93	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.16133491
94	Tyrosine metabolism_Homo sapiens_hsa00350	0.15719172
95	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.15492009
96	African trypanosomiasis_Homo sapiens_hsa05143	0.15123075
97	Dopaminergic synapse_Homo sapiens_hsa04728	0.14917049
98	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.14731954
99	Huntingtons disease_Homo sapiens_hsa05016	0.13527104
100	Phenylalanine metabolism_Homo sapiens_hsa00360	0.12977355

GAPDHP39

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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