GAPDHP40

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of sister chromatid cohesion (GO:0007063)9.81706897
2eosinophil migration (GO:0072677)9.64036266
3negative regulation of peptidyl-threonine phosphorylation (GO:0010801)9.55720953
4regulation of mononuclear cell migration (GO:0071675)9.45938263
5branch elongation of an epithelium (GO:0060602)8.50320732
6positive regulation of chromosome segregation (GO:0051984)8.02864327
7negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)8.02283046
8ribosomal small subunit assembly (GO:0000028)7.91115171
9L-fucose catabolic process (GO:0042355)7.90366079
10fucose catabolic process (GO:0019317)7.90366079
11L-fucose metabolic process (GO:0042354)7.90366079
12negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)7.85286946
13vesicle fusion (GO:0006906)7.71644498
14peptidyl-lysine dimethylation (GO:0018027)7.55760857
15coenzyme A biosynthetic process (GO:0015937)7.39335976
16autophagic vacuole fusion (GO:0000046)6.91708879
17macrophage chemotaxis (GO:0048246)6.69880371
18localization within membrane (GO:0051668)6.61239892
19organ growth (GO:0035265)6.59830597
20axis elongation (GO:0003401)6.33930299
21positive regulation of calcium ion import (GO:0090280)5.95565605
22establishment of mitotic spindle orientation (GO:0000132)5.91364975
23regulation of beta-amyloid formation (GO:1902003)5.91356249
24regulation of nitric-oxide synthase biosynthetic process (GO:0051769)5.91002069
25negative regulation of GTPase activity (GO:0034260)5.80265789
26negative regulation of GTP catabolic process (GO:0033125)5.80265789
27regulation of T cell receptor signaling pathway (GO:0050856)5.72935528
28monocyte chemotaxis (GO:0002548)5.60789844
29protein import into peroxisome matrix (GO:0016558)5.58196982
30non-recombinational repair (GO:0000726)5.45374856
31double-strand break repair via nonhomologous end joining (GO:0006303)5.45374856
32organelle membrane fusion (GO:0090174)5.44172381
33establishment of mitotic spindle localization (GO:0040001)5.24667377
34establishment of spindle orientation (GO:0051294)5.11917956
353-UTR-mediated mRNA stabilization (GO:0070935)5.11101136
36negative regulation of circadian rhythm (GO:0042754)4.96120942
37acrosome assembly (GO:0001675)4.92818893
38histone H3-K9 methylation (GO:0051567)4.81753633
39seminiferous tubule development (GO:0072520)4.77009592
40pantothenate metabolic process (GO:0015939)4.72493072
41regulation of amyloid precursor protein catabolic process (GO:1902991)4.72445673
42positive chemotaxis (GO:0050918)4.70203562
43ribonucleoside bisphosphate biosynthetic process (GO:0034030)4.66934359
44nucleoside bisphosphate biosynthetic process (GO:0033866)4.66934359
45purine nucleoside bisphosphate biosynthetic process (GO:0034033)4.66934359
46organelle fusion (GO:0048284)4.66200584
47oxidative demethylation (GO:0070989)4.63948838
48detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)4.63574096
49regulation of stem cell maintenance (GO:2000036)4.49111380
50fucose metabolic process (GO:0006004)4.46308161
51positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.43037876
52regulation of autophagic vacuole assembly (GO:2000785)4.42203019
53coenzyme A metabolic process (GO:0015936)4.35786742
54regulation of ER to Golgi vesicle-mediated transport (GO:0060628)4.26228329
55fucosylation (GO:0036065)4.18134377
56protein targeting to vacuole (GO:0006623)4.17403451
57protein targeting to lysosome (GO:0006622)4.17403451
58establishment of protein localization to vacuole (GO:0072666)4.17403451
59regulation of fibroblast growth factor receptor signaling pathway (GO:0040036)4.05404749
60regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.02575553
61negative regulation of purine nucleotide catabolic process (GO:0033122)4.00826752
62histone H3-K9 modification (GO:0061647)4.00419237
63membrane budding (GO:0006900)3.99685394
64detection of chemical stimulus involved in sensory perception of taste (GO:0050912)3.95934543
65single-organism membrane fusion (GO:0044801)3.85164071
66negative regulation of nucleotide catabolic process (GO:0030812)3.84223251
67regulation of cellular amide metabolic process (GO:0034248)3.83014188
68regulation of mammary gland epithelial cell proliferation (GO:0033599)3.82883194
69establishment of spindle localization (GO:0051293)3.76228867
70regulation of vacuole organization (GO:0044088)3.67989415
71negative regulation of nucleoside metabolic process (GO:0045978)3.67197180
72protein targeting to peroxisome (GO:0006625)3.66305340
73establishment of protein localization to peroxisome (GO:0072663)3.66305340
74protein localization to peroxisome (GO:0072662)3.66305340
75regulation of peptidyl-threonine phosphorylation (GO:0010799)3.64169493
76regulation of calcium ion import (GO:0090279)3.61467922
77vesicle targeting (GO:0006903)3.57805359
78DNA integration (GO:0015074)3.56731132
79ER to Golgi vesicle-mediated transport (GO:0006888)3.50736353
80negative regulation of macroautophagy (GO:0016242)3.50285268
81imidazole-containing compound metabolic process (GO:0052803)3.48231895
82telomere maintenance via recombination (GO:0000722)3.47593138
83sodium-independent organic anion transport (GO:0043252)3.46492112
84preassembly of GPI anchor in ER membrane (GO:0016254)3.42948756
85peroxisomal transport (GO:0043574)3.41552845
86regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:23.40263567
87negative regulation of dendrite morphogenesis (GO:0050774)3.39611194
88iron-sulfur cluster assembly (GO:0016226)3.35801416
89metallo-sulfur cluster assembly (GO:0031163)3.35801416
90proteasome assembly (GO:0043248)3.33571492
91Golgi transport vesicle coating (GO:0048200)3.28721576
92COPI coating of Golgi vesicle (GO:0048205)3.28721576
93prenylation (GO:0097354)12.8730666
94protein prenylation (GO:0018342)12.8730666
95positive regulation of mitotic sister chromatid separation (GO:1901970)12.3835463
96positive regulation of mitotic metaphase/anaphase transition (GO:0045842)12.3835463
97positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)12.3835463
98negative regulation of Ras GTPase activity (GO:0034261)12.2508016
99eosinophil chemotaxis (GO:0048245)10.6591407
100negative regulation of T cell receptor signaling pathway (GO:0050860)10.3492813

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse9.50090736
2VDR_22108803_ChIP-Seq_LS180_Human6.21028217
3RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.65773299
4NOTCH1_21737748_ChIP-Seq_TLL_Human4.64411970
5AR_21572438_ChIP-Seq_LNCaP_Human3.37223521
6SRY_22984422_ChIP-ChIP_TESTIS_Rat2.80258273
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.77760255
8ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.65201677
9ZNF263_19887448_ChIP-Seq_K562_Human2.62227882
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.55157190
11YY1_21170310_ChIP-Seq_MESCs_Mouse2.49073547
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.33234899
13TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.30350557
14GATA1_22025678_ChIP-Seq_K562_Human11.5709124
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.91783267
16PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.85549559
17POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.80550840
18TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.80550840
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.80207512
20RXR_22108803_ChIP-Seq_LS180_Human1.76289160
21SRF_21415370_ChIP-Seq_HL-1_Mouse1.66061068
22PCGF2_27294783_Chip-Seq_ESCs_Mouse1.58031213
23BCAT_22108803_ChIP-Seq_LS180_Human1.57184276
24KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.53059642
25KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.53059642
26KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.53059642
27P53_22127205_ChIP-Seq_FIBROBLAST_Human1.47586398
28TAF15_26573619_Chip-Seq_HEK293_Human1.39047784
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.37776895
30TP53_16413492_ChIP-PET_HCT116_Human1.36281312
31IRF1_19129219_ChIP-ChIP_H3396_Human1.33221707
32STAT3_1855785_ChIP-Seq_MESCs_Mouse1.26918656
33GATA3_26560356_Chip-Seq_TH1_Human1.26090237
34PCGF2_27294783_Chip-Seq_NPCs_Mouse1.20787674
35NR3C1_21868756_ChIP-Seq_MCF10A_Human1.16769932
36GBX2_23144817_ChIP-Seq_PC3_Human1.16703053
37GATA2_21666600_ChIP-Seq_HMVEC_Human1.15261789
38HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.13197653
39POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.11833318
40SUZ12_27294783_Chip-Seq_NPCs_Mouse1.07129836
41MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.03938067
42FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.01639367
43WDR5_24793694_ChIP-Seq_LNCAP_Human0.97142928
44GABP_17652178_ChIP-ChIP_JURKAT_Human0.97021533
45CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96892718
46ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.93225121
47CTCF_21964334_Chip-Seq_Bcells_Human0.91670074
48ETS1_20019798_ChIP-Seq_JURKAT_Human0.91181019
49FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.89982408
50RUNX_20019798_ChIP-Seq_JUKART_Human0.88846645
51NFE2_27457419_Chip-Seq_LIVER_Mouse0.86939658
52OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.86222134
53TBX3_20139965_ChIP-Seq_ESCs_Mouse0.84586190
54TBX3_20139965_ChIP-Seq_MESCs_Mouse0.84255564
55CDX2_20551321_ChIP-Seq_CACO-2_Human0.82585991
56MYC_18555785_ChIP-Seq_MESCs_Mouse0.81240072
57ZFP57_27257070_Chip-Seq_ESCs_Mouse0.80917092
58SOX3_22085726_ChIP-Seq_MUSCLE_Mouse0.79517755
59JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.77341510
60NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.76790938
61ZNF274_21170338_ChIP-Seq_K562_Hela0.76730629
62CTBP1_25329375_ChIP-Seq_LNCAP_Human0.73267679
63IKZF1_21737484_ChIP-ChIP_HCT116_Human0.73189435
64POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.71770880
65VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.71021676
66TP53_22573176_ChIP-Seq_HFKS_Human0.70551269
67TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.68994707
68GATA1_19941826_ChIP-Seq_K562_Human0.68738265
69SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.68344280
70JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.67603540
71EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.66908151
72REST_18959480_ChIP-ChIP_MESCs_Mouse0.65961114
73CTNNB1_20460455_ChIP-Seq_HCT116_Human0.65532691
74RING1B_27294783_Chip-Seq_NPCs_Mouse0.65301849
75KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.65045852
76FUS_26573619_Chip-Seq_HEK293_Human0.61332617
77GATA3_21867929_ChIP-Seq_TH1_Mouse0.61311427
78HTT_18923047_ChIP-ChIP_STHdh_Human0.60444151
79EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.59425081
80HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.58416225
81CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.58373751
82KAP1_22055183_ChIP-Seq_ESCs_Mouse0.57871809
83CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.57598731
84PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.57564334
85STAT1_20625510_ChIP-Seq_HELA_Human0.57315494
86TCF4_22108803_ChIP-Seq_LS180_Human0.57073469
87SMC1_22415368_ChIP-Seq_MEFs_Mouse0.56817356
88FOXH1_21741376_ChIP-Seq_ESCs_Human0.56712889
89TCF3_18692474_ChIP-Seq_MEFs_Mouse0.55842158
90FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.54011303
91GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.53701688
92LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.53304447
93NR3C1_23031785_ChIP-Seq_PC12_Mouse0.53155101
94FOXA1_25329375_ChIP-Seq_VCAP_Human0.52561646
95FOXA1_27270436_Chip-Seq_PROSTATE_Human0.52561646
96SMC3_22415368_ChIP-Seq_MEFs_Mouse0.51736929
97SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.51506688
98RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.50340713
99NANOG_20526341_ChIP-Seq_ESCs_Human0.50092828
100P300_19829295_ChIP-Seq_ESCs_Human0.49961580

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation9.92165221
2MP0006082_CNS_inflammation5.44778581
3MP0000467_abnormal_esophagus_morphology3.30989408
4MP0001664_abnormal_digestion3.21225973
5MP0001663_abnormal_digestive_system3.17888751
6MP0001919_abnormal_reproductive_system2.71182918
7MP0002751_abnormal_autonomic_nervous2.62089380
8MP0000383_abnormal_hair_follicle2.57445407
9MP0003115_abnormal_respiratory_system2.53925124
10MP0005381_digestive/alimentary_phenotyp2.46559844
11MP0000566_synostosis13.1753940
12MP0002876_abnormal_thyroid_physiology1.76955685
13MP0010678_abnormal_skin_adnexa1.76269831
14MP0005166_decreased_susceptibility_to1.75046941
15MP0001915_intracranial_hemorrhage1.68914455
16MP0005389_reproductive_system_phenotype1.62698729
17MP0000534_abnormal_ureter_morphology1.61205153
18MP0003937_abnormal_limbs/digits/tail_de1.61195642
19MP0003453_abnormal_keratinocyte_physiol1.53996624
20MP0000428_abnormal_craniofacial_morphol1.43901355
21MP0005397_hematopoietic_system_phenotyp1.42123380
22MP0001545_abnormal_hematopoietic_system1.42123380
23MP0005076_abnormal_cell_differentiation1.38288755
24MP0005501_abnormal_skin_physiology1.18542266
25MP0001293_anophthalmia1.13998841
26MP0001286_abnormal_eye_development1.12920585
27MP0000490_abnormal_crypts_of1.11905476
28MP0000858_altered_metastatic_potential1.07802357
29MP0003763_abnormal_thymus_physiology1.06564742
30MP0002019_abnormal_tumor_incidence0.91017664
31MP0003329_amyloid_beta_deposits0.89451780
32MP0002109_abnormal_limb_morphology0.86744815
33MP0001764_abnormal_homeostasis0.86238401
34MP0003942_abnormal_urinary_system0.81428320
35MP0000026_abnormal_inner_ear0.80435554
36MP0000470_abnormal_stomach_morphology0.79886927
37MP0001963_abnormal_hearing_physiology0.79789189
38MP0002115_abnormal_skeleton_extremities0.77027504
39MP0000358_abnormal_cell_content/0.74615024
40MP0010155_abnormal_intestine_physiology0.73137785
41MP0005197_abnormal_uvea_morphology0.72943198
42MP0000477_abnormal_intestine_morphology0.65997473
43MP0005508_abnormal_skeleton_morphology0.65271026
44MP0009763_increased_sensitivity_to0.64613898
45MP0000432_abnormal_head_morphology0.61307926
46MP0002405_respiratory_system_inflammati0.60044949
47MP0009672_abnormal_birth_weight0.59642168
48MP0002184_abnormal_innervation0.59188030
49MP0005023_abnormal_wound_healing0.57550107
50MP0000604_amyloidosis0.55764191
51MP0002210_abnormal_sex_determination0.53111215
52MP0003935_abnormal_craniofacial_develop0.51566469
53MP0001175_abnormal_lung_morphology0.49876121
54MP0005253_abnormal_eye_physiology0.49165934
55MP0008058_abnormal_DNA_repair0.47633257
56MP0002113_abnormal_skeleton_development0.47184398
57MP0000377_abnormal_hair_follicle0.46347644
58MP0000681_abnormal_thyroid_gland0.45265190
59MP0002822_catalepsy0.39487466
60MP0000627_abnormal_mammary_gland0.39074080
61MP0005391_vision/eye_phenotype0.38471113
62MP0003638_abnormal_response/metabolism_0.38450507
63MP0003448_altered_tumor_morphology0.37437601
64MP0002697_abnormal_eye_size0.37346405
65MP0000163_abnormal_cartilage_morphology0.35517488
66MP0003936_abnormal_reproductive_system0.35377216
67MP0002752_abnormal_somatic_nervous0.34054873
68MP0001986_abnormal_taste_sensitivity0.33008172
69MP0005025_abnormal_response_to0.30510776
70MP0005423_abnormal_somatic_nervous0.30355637
71MP0010771_integument_phenotype0.29065990
72MP0002136_abnormal_kidney_physiology0.28911099
73MP0003878_abnormal_ear_physiology0.28661225
74MP0005377_hearing/vestibular/ear_phenot0.28661225
75MP0000350_abnormal_cell_proliferation0.27625532
76MP0002168_other_aberrant_phenotype0.27572576
77MP0002735_abnormal_chemical_nociception0.26769473
78MP0002736_abnormal_nociception_after0.26569896
79MP0003195_calcinosis0.26488693
80MP0006276_abnormal_autonomic_nervous0.23907457
81MP0008004_abnormal_stomach_pH0.23737595
82MP0004197_abnormal_fetal_growth/weight/0.23640553
83MP0005390_skeleton_phenotype0.23069438
84MP0000049_abnormal_middle_ear0.23032957
85MP0005332_abnormal_amino_acid0.21749762
86MP0003880_abnormal_central_pattern0.21174349
87MP0000372_irregular_coat_pigmentation0.20740201
88MP0002452_abnormal_antigen_presenting0.20646126
89MP0005645_abnormal_hypothalamus_physiol0.20642352
90MP0002102_abnormal_ear_morphology0.20488686
91MP0002277_abnormal_respiratory_mucosa0.20234200
92MP0003283_abnormal_digestive_organ0.20117100
93MP0002837_dystrophic_cardiac_calcinosis0.19557637
94MP0002092_abnormal_eye_morphology0.19317681
95MP0003136_yellow_coat_color0.18696122
96MP0002116_abnormal_craniofacial_bone0.17579837
97MP0000955_abnormal_spinal_cord0.16792907
98MP0003315_abnormal_perineum_morphology0.16758581
99MP0009931_abnormal_skin_appearance0.16119742
100MP0003077_abnormal_cell_cycle0.15780998

Predicted human phenotypes

RankGene SetZ-score
1Duplicated collecting system (HP:0000081)9.32870138
2Long foot (HP:0001833)9.12565273
3Abnormality of the renal collecting system (HP:0004742)8.35334766
4Large for gestational age (HP:0001520)7.28334950
5Acute lymphatic leukemia (HP:0006721)7.10738585
6Adactyly (HP:0009776)6.75546372
7Progressive muscle weakness (HP:0003323)6.63888898
8Hypoplastic pelvis (HP:0008839)6.35620516
9Abnormality of fatty-acid metabolism (HP:0004359)6.24954373
10Dry hair (HP:0011359)5.92868093
11Autoamputation (HP:0001218)5.82085659
12Pulmonary artery stenosis (HP:0004415)5.64280328
13Ureteral stenosis (HP:0000071)5.47773732
14Steatorrhea (HP:0002570)5.20323329
15Brushfield spots (HP:0001088)5.20065481
16Menstrual irregularities (HP:0000858)5.18062847
17Ureteral duplication (HP:0000073)5.10595420
18Ureteral obstruction (HP:0006000)5.06804015
19Hypoplastic nipples (HP:0002557)4.91082516
20Abnormal auditory evoked potentials (HP:0006958)4.59431367
21Sudden death (HP:0001699)4.45678886
22Reduced subcutaneous adipose tissue (HP:0003758)4.41472193
23Abnormal ventriculo-arterial connection (HP:0011563)4.27271439
24Transposition of the great arteries (HP:0001669)4.27271439
25Abnormal connection of the cardiac segments (HP:0011545)4.27271439
26Severe muscular hypotonia (HP:0006829)4.21932342
27Decreased lacrimation (HP:0000633)4.07829469
28Fat malabsorption (HP:0002630)4.01778098
29Increased number of teeth (HP:0011069)3.98372630
30Anhidrosis (HP:0000970)3.96051996
31Broad-based gait (HP:0002136)3.81853231
32Palmoplantar hyperkeratosis (HP:0000972)3.74587569
33Palmar hyperkeratosis (HP:0010765)3.54253535
34Abnormality of vision evoked potentials (HP:0000649)3.46921656
35Wide intermamillary distance (HP:0006610)3.34991858
36Polyneuropathy (HP:0001271)3.31114503
37Generalized amyotrophy (HP:0003700)3.27795493
38Decreased muscle mass (HP:0003199)3.26906526
39Broad nasal tip (HP:0000455)3.20043325
40Polymicrogyria (HP:0002126)3.13082523
41Myoglobinuria (HP:0002913)3.13043243
42Large hands (HP:0001176)3.07670519
43Plantar hyperkeratosis (HP:0007556)3.01708088
44Rhabdomyolysis (HP:0003201)3.00612871
45Clubbing of toes (HP:0100760)2.73084750
46Flat face (HP:0012368)2.70147009
47Epiphyseal stippling (HP:0010655)2.67760117
48Chorioretinal coloboma (HP:0000567)2.61555212
49Steppage gait (HP:0003376)2.52845606
50Hypoplastic iliac wings (HP:0002866)2.50446231
51Overfolded helix (HP:0000396)2.45921089
52Thickened calvaria (HP:0002684)2.39981604
53Basal ganglia calcification (HP:0002135)2.39809735
54Widely spaced teeth (HP:0000687)2.37048695
55Purpura (HP:0000979)2.30905398
56Posterior embryotoxon (HP:0000627)2.29764400
57Abnormality of the line of Schwalbe (HP:0008048)2.21709440
58Abnormally folded helix (HP:0008544)2.21473507
59Anxiety (HP:0000739)2.19252319
60Aplasia/Hypoplasia of the nipples (HP:0006709)2.17838741
61Female pseudohermaphroditism (HP:0010458)2.13886964
62Absent toe (HP:0010760)2.13751476
63Foot dorsiflexor weakness (HP:0009027)2.12519357
64Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)2.04769481
65Abnormality of long-chain fatty-acid metabolism (HP:0010964)12.2744992
66Prenatal maternal abnormality (HP:0002686)1.98176023
67External ear malformation (HP:0008572)1.95567264
68Hammertoe (HP:0001765)1.95081039
69Abnormality of the foot musculature (HP:0001436)1.94602393
70Generalized muscle weakness (HP:0003324)1.91221025
71Thickened nuchal skin fold (HP:0000474)1.90907031
72Spastic tetraplegia (HP:0002510)1.90515446
73Abnormal epiphyseal ossification (HP:0010656)1.89137426
74Primary adrenal insufficiency (HP:0008207)1.88435074
75Arthrogryposis multiplex congenita (HP:0002804)1.83261715
76Congenital onset (HP:0003577)1.81136307
77Abnormality of the epiphyses of the hand (HP:0005924)1.79318911
78Gangrene (HP:0100758)1.78615821
79Stereotypic behavior (HP:0000733)1.75086977
80Depressed nasal ridge (HP:0000457)1.69631956
81Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.69259920
82Arterial thrombosis (HP:0004420)1.67033261
83Lactic acidosis (HP:0003128)1.66667063
84Decreased motor nerve conduction velocity (HP:0003431)1.66285450
85Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.64688351
86Brachycephaly (HP:0000248)1.60390089
87Short philtrum (HP:0000322)1.60021998
88Underdeveloped supraorbital ridges (HP:0009891)1.57444454
89Nail dystrophy (HP:0008404)1.56357394
90Scrotal hypoplasia (HP:0000046)1.55602170
91Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.52739936
92Respiratory insufficiency due to muscle weakness (HP:0002747)1.44792507
93Hypoplastic ilia (HP:0000946)1.42883903
94Opacification of the corneal stroma (HP:0007759)1.40841930
95Abnormality of primary teeth (HP:0006481)1.36543556
96Retinopathy (HP:0000488)1.34980614
97Postnatal microcephaly (HP:0005484)1.33997785
98Webbed neck (HP:0000465)1.32405944
99Postnatal growth retardation (HP:0008897)1.31938521
100Pulmonary embolism (HP:0002204)1.30342956

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MKNK16.84923196
2TAOK25.58387837
3TAOK15.50582716
4MAP3K34.11267806
5MAP3K114.00751266
6MAP2K33.99575587
7JAK32.44812266
8MKNK211.5520138
9ABL21.90666907
10DYRK1A1.76694432
11MAP3K51.34897219
12SRPK11.01880536
13MAP3K11.01512402
14CHEK20.82544638
15MAP3K80.67305640
16PRKCQ0.49338569
17CSNK1A10.20096160
18ABL10.15176166
19INSRR0.14689281
20IGF1R0.13887253
21OBSCN0.13008205
22WNK30.10970759
23TXK0.10124884
24MUSK0.10090464
25MAP4K20.09952365
26GRK10.08851419
27ADRBK20.08761761
28TIE10.08726315
29PRKCD0.08695115
30CSNK2A20.07138569
31GRK70.05081713
32CSNK2A10.03915314
33CSNK1E0.03251520
34AURKA0.02375452
35TLK10.01861021
36PIK3CG0.01081750
37MAPK150.01081177
38PRKCA0.00988461
39ERBB40.00467503
40ZAK0.00285610
41PRKACG-0.1147102
42MAP2K7-0.1146519
43FLT3-0.1132980
44MAPK13-0.1121722
45MAP4K1-0.1120819
46IKBKE-0.1115833
47TNK2-0.1114993
48TGFBR1-0.1113314
49PIM1-0.1084748
50PASK-0.1078058
51LYN-0.1074500
52PIK3CA-0.1069802
53PRKG1-0.1067738
54DAPK3-0.1018435
55MAPK14-0.1007641
56BTK-0.0982393
57BMPR1B-0.0978459
58BCKDK-0.0954294
59STK16-0.0954117
60BLK-0.0948541
61SYK-0.0947382
62PKN1-0.0947081
63PRKCE-0.0889413
64TTN-0.0878494
65MYLK-0.0876962
66CAMK2G-0.0872279
67CCNB1-0.0868367
68CAMK2A-0.0864364
69CDK2-0.0861612
70GRK6-0.0856745
71FRK-0.0850354
72MST1R-0.0826631
73EPHA2-0.0806650
74PIM2-0.0795454
75ADRBK1-0.0792389
76EPHB2-0.0788010
77MAPKAPK5-0.0787236
78MAP2K6-0.0786536
79PINK1-0.0742847
80DDR2-0.0741548
81STK39-0.0715813
82NTRK2-0.0637562
83LMTK2-0.0621058
84VRK1-0.0616436
85PRKCG-0.0589269
86ITK-0.0513970
87KIT-0.0479208
88TEC-0.0469276
89OXSR1-0.0454606
90MATK-0.0398887
91SRC-0.0339280
92KDR-0.0337746
93PHKG1-0.0337655
94PHKG2-0.0337655
95EPHA4-0.0315938
96WNK4-0.0309997
97GRK5-0.0262853
98PRKACA-0.0210437
99PLK4-0.0096670
100PRKCB-0.0081275

Predicted pathways (KEGG)

RankGene SetZ-score
1SNARE interactions in vesicular transport_Homo sapiens_hsa041308.48586739
2Pantothenate and CoA biosynthesis_Homo sapiens_hsa007707.19455723
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.32602783
4RNA polymerase_Homo sapiens_hsa030203.17487465
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.12531179
6Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.01984494
7Taste transduction_Homo sapiens_hsa047422.97189114
8Fatty acid elongation_Homo sapiens_hsa000622.87153108
9Lysine degradation_Homo sapiens_hsa003102.59637851
10Butanoate metabolism_Homo sapiens_hsa006502.48003783
11Proteasome_Homo sapiens_hsa030502.03404453
12beta-Alanine metabolism_Homo sapiens_hsa004101.99725406
13One carbon pool by folate_Homo sapiens_hsa006701.87691020
14Tryptophan metabolism_Homo sapiens_hsa003801.82865081
15Glycerolipid metabolism_Homo sapiens_hsa005611.81521914
16Amoebiasis_Homo sapiens_hsa051461.74333060
17Propanoate metabolism_Homo sapiens_hsa006401.68152768
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.28366593
19Fatty acid degradation_Homo sapiens_hsa000711.19326911
20Viral myocarditis_Homo sapiens_hsa054161.15014309
21Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.11062230
22Fatty acid metabolism_Homo sapiens_hsa012120.98331595
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.93897156
24Peroxisome_Homo sapiens_hsa041460.90199986
25Complement and coagulation cascades_Homo sapiens_hsa046100.90037534
26Glycerophospholipid metabolism_Homo sapiens_hsa005640.75336449
27Epstein-Barr virus infection_Homo sapiens_hsa051690.68532722
28Pyrimidine metabolism_Homo sapiens_hsa002400.64154285
29Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.63914273
30Caffeine metabolism_Homo sapiens_hsa002320.63635026
31Maturity onset diabetes of the young_Homo sapiens_hsa049500.61928081
32AMPK signaling pathway_Homo sapiens_hsa041520.60996201
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.59885700
34Asthma_Homo sapiens_hsa053100.58747684
35Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.54860572
36Nucleotide excision repair_Homo sapiens_hsa034200.53590246
37MicroRNAs in cancer_Homo sapiens_hsa052060.52453693
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.51931923
39Retinol metabolism_Homo sapiens_hsa008300.51214016
40Olfactory transduction_Homo sapiens_hsa047400.51087110
41Toll-like receptor signaling pathway_Homo sapiens_hsa046200.50048749
42Autoimmune thyroid disease_Homo sapiens_hsa053200.49987290
43Transcriptional misregulation in cancer_Homo sapiens_hsa052020.49695125
44Nicotine addiction_Homo sapiens_hsa050330.47770931
45Steroid hormone biosynthesis_Homo sapiens_hsa001400.47532541
46Allograft rejection_Homo sapiens_hsa053300.46266887
47Cholinergic synapse_Homo sapiens_hsa047250.45996796
48Graft-versus-host disease_Homo sapiens_hsa053320.45531783
49Salmonella infection_Homo sapiens_hsa051320.45492116
50Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.43227161
51Linoleic acid metabolism_Homo sapiens_hsa005910.39374453
52Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.39241778
53Type I diabetes mellitus_Homo sapiens_hsa049400.37833562
54Phosphatidylinositol signaling system_Homo sapiens_hsa040700.37774078
55Systemic lupus erythematosus_Homo sapiens_hsa053220.37589046
56Intestinal immune network for IgA production_Homo sapiens_hsa046720.37345782
57Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.37249455
58Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.36711302
59Choline metabolism in cancer_Homo sapiens_hsa052310.35691755
60Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.35678830
61Hematopoietic cell lineage_Homo sapiens_hsa046400.34759541
62Fat digestion and absorption_Homo sapiens_hsa049750.33986375
63Chemical carcinogenesis_Homo sapiens_hsa052040.33944334
64RNA transport_Homo sapiens_hsa030130.33722147
65GnRH signaling pathway_Homo sapiens_hsa049120.33714995
66Purine metabolism_Homo sapiens_hsa002300.33204707
67Phototransduction_Homo sapiens_hsa047440.31214530
68TNF signaling pathway_Homo sapiens_hsa046680.31078394
69Nitrogen metabolism_Homo sapiens_hsa009100.30119601
70Toxoplasmosis_Homo sapiens_hsa051450.30082493
71Malaria_Homo sapiens_hsa051440.26630565
72Tyrosine metabolism_Homo sapiens_hsa003500.25845558
73Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.25140354
74Protein digestion and absorption_Homo sapiens_hsa049740.24969289
75Staphylococcus aureus infection_Homo sapiens_hsa051500.23962929
76Primary immunodeficiency_Homo sapiens_hsa053400.23577755
77Phagosome_Homo sapiens_hsa041450.22584625
78Pentose and glucuronate interconversions_Homo sapiens_hsa000400.22210005
79Arachidonic acid metabolism_Homo sapiens_hsa005900.19937455
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.19649925
81Oxytocin signaling pathway_Homo sapiens_hsa049210.17927700
82Ovarian steroidogenesis_Homo sapiens_hsa049130.16080377
83ECM-receptor interaction_Homo sapiens_hsa045120.15188405
84Phenylalanine metabolism_Homo sapiens_hsa003600.14495838
85Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.13401376
86Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.13239114
87Metabolic pathways_Homo sapiens_hsa011000.13232327
88African trypanosomiasis_Homo sapiens_hsa051430.12601790
89Rheumatoid arthritis_Homo sapiens_hsa053230.12365438
90Starch and sucrose metabolism_Homo sapiens_hsa005000.12164378
91Drug metabolism - other enzymes_Homo sapiens_hsa009830.11479919
92Vitamin digestion and absorption_Homo sapiens_hsa049770.10734687
93Bile secretion_Homo sapiens_hsa049760.07721789
94alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.07528254
95Primary bile acid biosynthesis_Homo sapiens_hsa001200.07079933
96Tuberculosis_Homo sapiens_hsa051520.06914619
97Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.06668304
98MAPK signaling pathway_Homo sapiens_hsa040100.05413816
99Rap1 signaling pathway_Homo sapiens_hsa040150.04534877
100Renin-angiotensin system_Homo sapiens_hsa046140.03973663

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