ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of sister chromatid cohesion (GO:0007063)	9.81706897
2	eosinophil migration (GO:0072677)	9.64036266
3	negative regulation of peptidyl-threonine phosphorylation (GO:0010801)	9.55720953
4	regulation of mononuclear cell migration (GO:0071675)	9.45938263
5	branch elongation of an epithelium (GO:0060602)	8.50320732
6	positive regulation of chromosome segregation (GO:0051984)	8.02864327
7	negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)	8.02283046
8	ribosomal small subunit assembly (GO:0000028)	7.91115171
9	L-fucose catabolic process (GO:0042355)	7.90366079
10	fucose catabolic process (GO:0019317)	7.90366079
11	L-fucose metabolic process (GO:0042354)	7.90366079
12	negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)	7.85286946
13	vesicle fusion (GO:0006906)	7.71644498
14	peptidyl-lysine dimethylation (GO:0018027)	7.55760857
15	coenzyme A biosynthetic process (GO:0015937)	7.39335976
16	autophagic vacuole fusion (GO:0000046)	6.91708879
17	macrophage chemotaxis (GO:0048246)	6.69880371
18	localization within membrane (GO:0051668)	6.61239892
19	organ growth (GO:0035265)	6.59830597
20	axis elongation (GO:0003401)	6.33930299
21	positive regulation of calcium ion import (GO:0090280)	5.95565605
22	establishment of mitotic spindle orientation (GO:0000132)	5.91364975
23	regulation of beta-amyloid formation (GO:1902003)	5.91356249
24	regulation of nitric-oxide synthase biosynthetic process (GO:0051769)	5.91002069
25	negative regulation of GTPase activity (GO:0034260)	5.80265789
26	negative regulation of GTP catabolic process (GO:0033125)	5.80265789
27	regulation of T cell receptor signaling pathway (GO:0050856)	5.72935528
28	monocyte chemotaxis (GO:0002548)	5.60789844
29	protein import into peroxisome matrix (GO:0016558)	5.58196982
30	double-strand break repair via nonhomologous end joining (GO:0006303)	5.45374856
31	non-recombinational repair (GO:0000726)	5.45374856
32	organelle membrane fusion (GO:0090174)	5.44172381
33	establishment of mitotic spindle localization (GO:0040001)	5.24667377
34	establishment of spindle orientation (GO:0051294)	5.11917956
35	3-UTR-mediated mRNA stabilization (GO:0070935)	5.11101136
36	negative regulation of circadian rhythm (GO:0042754)	4.96120942
37	acrosome assembly (GO:0001675)	4.92818893
38	histone H3-K9 methylation (GO:0051567)	4.81753633
39	seminiferous tubule development (GO:0072520)	4.77009592
40	pantothenate metabolic process (GO:0015939)	4.72493072
41	regulation of amyloid precursor protein catabolic process (GO:1902991)	4.72445673
42	positive chemotaxis (GO:0050918)	4.70203562
43	purine nucleoside bisphosphate biosynthetic process (GO:0034033)	4.66934359
44	ribonucleoside bisphosphate biosynthetic process (GO:0034030)	4.66934359
45	nucleoside bisphosphate biosynthetic process (GO:0033866)	4.66934359
46	organelle fusion (GO:0048284)	4.66200584
47	oxidative demethylation (GO:0070989)	4.63948838
48	detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)	4.63574096
49	regulation of stem cell maintenance (GO:2000036)	4.49111380
50	fucose metabolic process (GO:0006004)	4.46308161
51	positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)	4.43037876
52	regulation of autophagic vacuole assembly (GO:2000785)	4.42203019
53	coenzyme A metabolic process (GO:0015936)	4.35786742
54	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	4.26228329
55	fucosylation (GO:0036065)	4.18134377
56	protein targeting to vacuole (GO:0006623)	4.17403451
57	protein targeting to lysosome (GO:0006622)	4.17403451
58	establishment of protein localization to vacuole (GO:0072666)	4.17403451
59	regulation of fibroblast growth factor receptor signaling pathway (GO:0040036)	4.05404749
60	regulation of antigen receptor-mediated signaling pathway (GO:0050854)	4.02575553
61	negative regulation of purine nucleotide catabolic process (GO:0033122)	4.00826752
62	histone H3-K9 modification (GO:0061647)	4.00419237
63	membrane budding (GO:0006900)	3.99685394
64	detection of chemical stimulus involved in sensory perception of taste (GO:0050912)	3.95934543
65	single-organism membrane fusion (GO:0044801)	3.85164071
66	negative regulation of nucleotide catabolic process (GO:0030812)	3.84223251
67	regulation of cellular amide metabolic process (GO:0034248)	3.83014188
68	regulation of mammary gland epithelial cell proliferation (GO:0033599)	3.82883194
69	establishment of spindle localization (GO:0051293)	3.76228867
70	regulation of vacuole organization (GO:0044088)	3.67989415
71	negative regulation of nucleoside metabolic process (GO:0045978)	3.67197180
72	protein targeting to peroxisome (GO:0006625)	3.66305340
73	establishment of protein localization to peroxisome (GO:0072663)	3.66305340
74	protein localization to peroxisome (GO:0072662)	3.66305340
75	regulation of peptidyl-threonine phosphorylation (GO:0010799)	3.64169493
76	regulation of calcium ion import (GO:0090279)	3.61467922
77	vesicle targeting (GO:0006903)	3.57805359
78	DNA integration (GO:0015074)	3.56731132
79	ER to Golgi vesicle-mediated transport (GO:0006888)	3.50736353
80	negative regulation of macroautophagy (GO:0016242)	3.50285268
81	imidazole-containing compound metabolic process (GO:0052803)	3.48231895
82	telomere maintenance via recombination (GO:0000722)	3.47593138
83	sodium-independent organic anion transport (GO:0043252)	3.46492112
84	preassembly of GPI anchor in ER membrane (GO:0016254)	3.42948756
85	peroxisomal transport (GO:0043574)	3.41552845
86	regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:2	3.40263567
87	negative regulation of dendrite morphogenesis (GO:0050774)	3.39611194
88	iron-sulfur cluster assembly (GO:0016226)	3.35801416
89	metallo-sulfur cluster assembly (GO:0031163)	3.35801416
90	proteasome assembly (GO:0043248)	3.33571492
91	COPI coating of Golgi vesicle (GO:0048205)	3.28721576
92	Golgi transport vesicle coating (GO:0048200)	3.28721576
93	prenylation (GO:0097354)	12.8730666
94	protein prenylation (GO:0018342)	12.8730666
95	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	12.3835463
96	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	12.3835463
97	positive regulation of mitotic sister chromatid separation (GO:1901970)	12.3835463
98	negative regulation of Ras GTPase activity (GO:0034261)	12.2508016
99	eosinophil chemotaxis (GO:0048245)	10.6591407
100	negative regulation of T cell receptor signaling pathway (GO:0050860)	10.3492813

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	9.50090736
2	VDR_22108803_ChIP-Seq_LS180_Human	6.21028217
3	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	4.65773299
4	NOTCH1_21737748_ChIP-Seq_TLL_Human	4.64411970
5	AR_21572438_ChIP-Seq_LNCaP_Human	3.37223521
6	SRY_22984422_ChIP-ChIP_TESTIS_Rat	2.80258273
7	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.77760255
8	ZIC3_20872845_ChIP-ChIP_MESCs_Mouse	2.65201677
9	ZNF263_19887448_ChIP-Seq_K562_Human	2.62227882
10	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.55157190
11	YY1_21170310_ChIP-Seq_MESCs_Mouse	2.49073547
12	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.33234899
13	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	2.30350557
14	GATA1_22025678_ChIP-Seq_K562_Human	11.5709124
15	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.91783267
16	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.85549559
17	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.80550840
18	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.80550840
19	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.80207512
20	RXR_22108803_ChIP-Seq_LS180_Human	1.76289160
21	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.66061068
22	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.58031213
23	BCAT_22108803_ChIP-Seq_LS180_Human	1.57184276
24	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.53059642
25	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.53059642
26	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.53059642
27	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.47586398
28	TAF15_26573619_Chip-Seq_HEK293_Human	1.39047784
29	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.37776895
30	TP53_16413492_ChIP-PET_HCT116_Human	1.36281312
31	IRF1_19129219_ChIP-ChIP_H3396_Human	1.33221707
32	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.26918656
33	GATA3_26560356_Chip-Seq_TH1_Human	1.26090237
34	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.20787674
35	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.16769932
36	GBX2_23144817_ChIP-Seq_PC3_Human	1.16703053
37	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.15261789
38	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.13197653
39	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	1.11833318
40	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.07129836
41	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.03938067
42	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.01639367
43	WDR5_24793694_ChIP-Seq_LNCAP_Human	0.97142928
44	GABP_17652178_ChIP-ChIP_JURKAT_Human	0.97021533
45	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.96892718
46	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	0.93225121
47	CTCF_21964334_Chip-Seq_Bcells_Human	0.91670074
48	ETS1_20019798_ChIP-Seq_JURKAT_Human	0.91181019
49	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	0.89982408
50	RUNX_20019798_ChIP-Seq_JUKART_Human	0.88846645
51	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.86939658
52	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.86222134
53	TBX3_20139965_ChIP-Seq_ESCs_Mouse	0.84586190
54	TBX3_20139965_ChIP-Seq_MESCs_Mouse	0.84255564
55	CDX2_20551321_ChIP-Seq_CACO-2_Human	0.82585991
56	MYC_18555785_ChIP-Seq_MESCs_Mouse	0.81240072
57	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.80917092
58	SOX3_22085726_ChIP-Seq_MUSCLE_Mouse	0.79517755
59	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.77341510
60	NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human	0.76790938
61	ZNF274_21170338_ChIP-Seq_K562_Hela	0.76730629
62	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.73267679
63	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.73189435
64	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.71770880
65	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	0.71021676
66	TP53_22573176_ChIP-Seq_HFKS_Human	0.70551269
67	TRIM28_19339689_ChIP-ChIP_MESCs_Mouse	0.68994707
68	GATA1_19941826_ChIP-Seq_K562_Human	0.68738265
69	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	0.68344280
70	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	0.67603540
71	EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	0.66908151
72	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.65961114
73	CTNNB1_20460455_ChIP-Seq_HCT116_Human	0.65532691
74	RING1B_27294783_Chip-Seq_NPCs_Mouse	0.65301849
75	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.65045852
76	FUS_26573619_Chip-Seq_HEK293_Human	0.61332617
77	GATA3_21867929_ChIP-Seq_TH1_Mouse	0.61311427
78	HTT_18923047_ChIP-ChIP_STHdh_Human	0.60444151
79	EOMES_20176728_ChIP-ChIP_TSCs_Mouse	0.59425081
80	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.58416225
81	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.58373751
82	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.57871809
83	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.57598731
84	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.57564334
85	STAT1_20625510_ChIP-Seq_HELA_Human	0.57315494
86	TCF4_22108803_ChIP-Seq_LS180_Human	0.57073469
87	SMC1_22415368_ChIP-Seq_MEFs_Mouse	0.56817356
88	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.56712889
89	TCF3_18692474_ChIP-Seq_MEFs_Mouse	0.55842158
90	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.54011303
91	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	0.53701688
92	LUZP1_20508642_ChIP-Seq_ESCs_Mouse	0.53304447
93	NR3C1_23031785_ChIP-Seq_PC12_Mouse	0.53155101
94	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.52561646
95	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.52561646
96	SMC3_22415368_ChIP-Seq_MEFs_Mouse	0.51736929
97	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.51506688
98	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.50340713
99	NANOG_20526341_ChIP-Seq_ESCs_Human	0.50092828
100	P300_19829295_ChIP-Seq_ESCs_Human	0.49961580

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003303_peritoneal_inflammation	9.92165221
2	MP0006082_CNS_inflammation	5.44778581
3	MP0000467_abnormal_esophagus_morphology	3.30989408
4	MP0001664_abnormal_digestion	3.21225973
5	MP0001663_abnormal_digestive_system	3.17888751
6	MP0001919_abnormal_reproductive_system	2.71182918
7	MP0002751_abnormal_autonomic_nervous	2.62089380
8	MP0000383_abnormal_hair_follicle	2.57445407
9	MP0003115_abnormal_respiratory_system	2.53925124
10	MP0005381_digestive/alimentary_phenotyp	2.46559844
11	MP0000566_synostosis	13.1753940
12	MP0002876_abnormal_thyroid_physiology	1.76955685
13	MP0010678_abnormal_skin_adnexa	1.76269831
14	MP0005166_decreased_susceptibility_to	1.75046941
15	MP0001915_intracranial_hemorrhage	1.68914455
16	MP0005389_reproductive_system_phenotype	1.62698729
17	MP0000534_abnormal_ureter_morphology	1.61205153
18	MP0003937_abnormal_limbs/digits/tail_de	1.61195642
19	MP0003453_abnormal_keratinocyte_physiol	1.53996624
20	MP0000428_abnormal_craniofacial_morphol	1.43901355
21	MP0001545_abnormal_hematopoietic_system	1.42123380
22	MP0005397_hematopoietic_system_phenotyp	1.42123380
23	MP0005076_abnormal_cell_differentiation	1.38288755
24	MP0005501_abnormal_skin_physiology	1.18542266
25	MP0001293_anophthalmia	1.13998841
26	MP0001286_abnormal_eye_development	1.12920585
27	MP0000490_abnormal_crypts_of	1.11905476
28	MP0000858_altered_metastatic_potential	1.07802357
29	MP0003763_abnormal_thymus_physiology	1.06564742
30	MP0002019_abnormal_tumor_incidence	0.91017664
31	MP0003329_amyloid_beta_deposits	0.89451780
32	MP0002109_abnormal_limb_morphology	0.86744815
33	MP0001764_abnormal_homeostasis	0.86238401
34	MP0003942_abnormal_urinary_system	0.81428320
35	MP0000026_abnormal_inner_ear	0.80435554
36	MP0000470_abnormal_stomach_morphology	0.79886927
37	MP0001963_abnormal_hearing_physiology	0.79789189
38	MP0002115_abnormal_skeleton_extremities	0.77027504
39	MP0000358_abnormal_cell_content/	0.74615024
40	MP0010155_abnormal_intestine_physiology	0.73137785
41	MP0005197_abnormal_uvea_morphology	0.72943198
42	MP0000477_abnormal_intestine_morphology	0.65997473
43	MP0005508_abnormal_skeleton_morphology	0.65271026
44	MP0009763_increased_sensitivity_to	0.64613898
45	MP0000432_abnormal_head_morphology	0.61307926
46	MP0002405_respiratory_system_inflammati	0.60044949
47	MP0009672_abnormal_birth_weight	0.59642168
48	MP0002184_abnormal_innervation	0.59188030
49	MP0005023_abnormal_wound_healing	0.57550107
50	MP0000604_amyloidosis	0.55764191
51	MP0002210_abnormal_sex_determination	0.53111215
52	MP0003935_abnormal_craniofacial_develop	0.51566469
53	MP0001175_abnormal_lung_morphology	0.49876121
54	MP0005253_abnormal_eye_physiology	0.49165934
55	MP0008058_abnormal_DNA_repair	0.47633257
56	MP0002113_abnormal_skeleton_development	0.47184398
57	MP0000377_abnormal_hair_follicle	0.46347644
58	MP0000681_abnormal_thyroid_gland	0.45265190
59	MP0002822_catalepsy	0.39487466
60	MP0000627_abnormal_mammary_gland	0.39074080
61	MP0005391_vision/eye_phenotype	0.38471113
62	MP0003638_abnormal_response/metabolism_	0.38450507
63	MP0003448_altered_tumor_morphology	0.37437601
64	MP0002697_abnormal_eye_size	0.37346405
65	MP0000163_abnormal_cartilage_morphology	0.35517488
66	MP0003936_abnormal_reproductive_system	0.35377216
67	MP0002752_abnormal_somatic_nervous	0.34054873
68	MP0001986_abnormal_taste_sensitivity	0.33008172
69	MP0005025_abnormal_response_to	0.30510776
70	MP0005423_abnormal_somatic_nervous	0.30355637
71	MP0010771_integument_phenotype	0.29065990
72	MP0002136_abnormal_kidney_physiology	0.28911099
73	MP0005377_hearing/vestibular/ear_phenot	0.28661225
74	MP0003878_abnormal_ear_physiology	0.28661225
75	MP0000350_abnormal_cell_proliferation	0.27625532
76	MP0002168_other_aberrant_phenotype	0.27572576
77	MP0002735_abnormal_chemical_nociception	0.26769473
78	MP0002736_abnormal_nociception_after	0.26569896
79	MP0003195_calcinosis	0.26488693
80	MP0006276_abnormal_autonomic_nervous	0.23907457
81	MP0008004_abnormal_stomach_pH	0.23737595
82	MP0004197_abnormal_fetal_growth/weight/	0.23640553
83	MP0005390_skeleton_phenotype	0.23069438
84	MP0000049_abnormal_middle_ear	0.23032957
85	MP0005332_abnormal_amino_acid	0.21749762
86	MP0003880_abnormal_central_pattern	0.21174349
87	MP0000372_irregular_coat_pigmentation	0.20740201
88	MP0002452_abnormal_antigen_presenting	0.20646126
89	MP0005645_abnormal_hypothalamus_physiol	0.20642352
90	MP0002102_abnormal_ear_morphology	0.20488686
91	MP0002277_abnormal_respiratory_mucosa	0.20234200
92	MP0003283_abnormal_digestive_organ	0.20117100
93	MP0002837_dystrophic_cardiac_calcinosis	0.19557637
94	MP0002092_abnormal_eye_morphology	0.19317681
95	MP0003136_yellow_coat_color	0.18696122
96	MP0002116_abnormal_craniofacial_bone	0.17579837
97	MP0000955_abnormal_spinal_cord	0.16792907
98	MP0003315_abnormal_perineum_morphology	0.16758581
99	MP0009931_abnormal_skin_appearance	0.16119742
100	MP0003077_abnormal_cell_cycle	0.15780998

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Duplicated collecting system (HP:0000081)	9.32870138
2	Long foot (HP:0001833)	9.12565273
3	Abnormality of the renal collecting system (HP:0004742)	8.35334766
4	Large for gestational age (HP:0001520)	7.28334950
5	Acute lymphatic leukemia (HP:0006721)	7.10738585
6	Adactyly (HP:0009776)	6.75546372
7	Progressive muscle weakness (HP:0003323)	6.63888898
8	Hypoplastic pelvis (HP:0008839)	6.35620516
9	Abnormality of fatty-acid metabolism (HP:0004359)	6.24954373
10	Dry hair (HP:0011359)	5.92868093
11	Autoamputation (HP:0001218)	5.82085659
12	Pulmonary artery stenosis (HP:0004415)	5.64280328
13	Ureteral stenosis (HP:0000071)	5.47773732
14	Steatorrhea (HP:0002570)	5.20323329
15	Brushfield spots (HP:0001088)	5.20065481
16	Menstrual irregularities (HP:0000858)	5.18062847
17	Ureteral duplication (HP:0000073)	5.10595420
18	Ureteral obstruction (HP:0006000)	5.06804015
19	Hypoplastic nipples (HP:0002557)	4.91082516
20	Abnormal auditory evoked potentials (HP:0006958)	4.59431367
21	Sudden death (HP:0001699)	4.45678886
22	Reduced subcutaneous adipose tissue (HP:0003758)	4.41472193
23	Abnormal ventriculo-arterial connection (HP:0011563)	4.27271439
24	Transposition of the great arteries (HP:0001669)	4.27271439
25	Abnormal connection of the cardiac segments (HP:0011545)	4.27271439
26	Severe muscular hypotonia (HP:0006829)	4.21932342
27	Decreased lacrimation (HP:0000633)	4.07829469
28	Fat malabsorption (HP:0002630)	4.01778098
29	Increased number of teeth (HP:0011069)	3.98372630
30	Anhidrosis (HP:0000970)	3.96051996
31	Broad-based gait (HP:0002136)	3.81853231
32	Palmoplantar hyperkeratosis (HP:0000972)	3.74587569
33	Palmar hyperkeratosis (HP:0010765)	3.54253535
34	Abnormality of vision evoked potentials (HP:0000649)	3.46921656
35	Wide intermamillary distance (HP:0006610)	3.34991858
36	Polyneuropathy (HP:0001271)	3.31114503
37	Generalized amyotrophy (HP:0003700)	3.27795493
38	Decreased muscle mass (HP:0003199)	3.26906526
39	Broad nasal tip (HP:0000455)	3.20043325
40	Polymicrogyria (HP:0002126)	3.13082523
41	Myoglobinuria (HP:0002913)	3.13043243
42	Large hands (HP:0001176)	3.07670519
43	Plantar hyperkeratosis (HP:0007556)	3.01708088
44	Rhabdomyolysis (HP:0003201)	3.00612871
45	Clubbing of toes (HP:0100760)	2.73084750
46	Flat face (HP:0012368)	2.70147009
47	Epiphyseal stippling (HP:0010655)	2.67760117
48	Chorioretinal coloboma (HP:0000567)	2.61555212
49	Steppage gait (HP:0003376)	2.52845606
50	Hypoplastic iliac wings (HP:0002866)	2.50446231
51	Overfolded helix (HP:0000396)	2.45921089
52	Thickened calvaria (HP:0002684)	2.39981604
53	Basal ganglia calcification (HP:0002135)	2.39809735
54	Widely spaced teeth (HP:0000687)	2.37048695
55	Purpura (HP:0000979)	2.30905398
56	Posterior embryotoxon (HP:0000627)	2.29764400
57	Abnormality of the line of Schwalbe (HP:0008048)	2.21709440
58	Abnormally folded helix (HP:0008544)	2.21473507
59	Anxiety (HP:0000739)	2.19252319
60	Aplasia/Hypoplasia of the nipples (HP:0006709)	2.17838741
61	Female pseudohermaphroditism (HP:0010458)	2.13886964
62	Absent toe (HP:0010760)	2.13751476
63	Foot dorsiflexor weakness (HP:0009027)	2.12519357
64	Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)	2.04769481
65	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	12.2744992
66	Prenatal maternal abnormality (HP:0002686)	1.98176023
67	External ear malformation (HP:0008572)	1.95567264
68	Hammertoe (HP:0001765)	1.95081039
69	Abnormality of the foot musculature (HP:0001436)	1.94602393
70	Generalized muscle weakness (HP:0003324)	1.91221025
71	Thickened nuchal skin fold (HP:0000474)	1.90907031
72	Spastic tetraplegia (HP:0002510)	1.90515446
73	Abnormal epiphyseal ossification (HP:0010656)	1.89137426
74	Primary adrenal insufficiency (HP:0008207)	1.88435074
75	Arthrogryposis multiplex congenita (HP:0002804)	1.83261715
76	Congenital onset (HP:0003577)	1.81136307
77	Abnormality of the epiphyses of the hand (HP:0005924)	1.79318911
78	Gangrene (HP:0100758)	1.78615821
79	Stereotypic behavior (HP:0000733)	1.75086977
80	Depressed nasal ridge (HP:0000457)	1.69631956
81	Abnormality involving the epiphyses of the upper limbs (HP:0003839)	1.69259920
82	Arterial thrombosis (HP:0004420)	1.67033261
83	Lactic acidosis (HP:0003128)	1.66667063
84	Decreased motor nerve conduction velocity (HP:0003431)	1.66285450
85	Decreased number of peripheral myelinated nerve fibers (HP:0003380)	1.64688351
86	Brachycephaly (HP:0000248)	1.60390089
87	Short philtrum (HP:0000322)	1.60021998
88	Underdeveloped supraorbital ridges (HP:0009891)	1.57444454
89	Nail dystrophy (HP:0008404)	1.56357394
90	Scrotal hypoplasia (HP:0000046)	1.55602170
91	Aplasia/Hypoplasia involving the pelvis (HP:0009103)	1.52739936
92	Respiratory insufficiency due to muscle weakness (HP:0002747)	1.44792507
93	Hypoplastic ilia (HP:0000946)	1.42883903
94	Opacification of the corneal stroma (HP:0007759)	1.40841930
95	Abnormality of primary teeth (HP:0006481)	1.36543556
96	Retinopathy (HP:0000488)	1.34980614
97	Postnatal microcephaly (HP:0005484)	1.33997785
98	Webbed neck (HP:0000465)	1.32405944
99	Postnatal growth retardation (HP:0008897)	1.31938521
100	Pulmonary embolism (HP:0002204)	1.30342956

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MKNK1	6.84923196
2	TAOK2	5.58387837
3	TAOK1	5.50582716
4	MAP3K3	4.11267806
5	MAP3K11	4.00751266
6	MAP2K3	3.99575587
7	JAK3	2.44812266
8	MKNK2	11.5520138
9	ABL2	1.90666907
10	DYRK1A	1.76694432
11	MAP3K5	1.34897219
12	SRPK1	1.01880536
13	MAP3K1	1.01512402
14	CHEK2	0.82544638
15	MAP3K8	0.67305640
16	PRKCQ	0.49338569
17	CSNK1A1	0.20096160
18	ABL1	0.15176166
19	INSRR	0.14689281
20	IGF1R	0.13887253
21	OBSCN	0.13008205
22	WNK3	0.10970759
23	TXK	0.10124884
24	MUSK	0.10090464
25	MAP4K2	0.09952365
26	GRK1	0.08851419
27	ADRBK2	0.08761761
28	TIE1	0.08726315
29	PRKCD	0.08695115
30	CSNK2A2	0.07138569
31	GRK7	0.05081713
32	CSNK2A1	0.03915314
33	CSNK1E	0.03251520
34	AURKA	0.02375452
35	TLK1	0.01861021
36	PIK3CG	0.01081750
37	MAPK15	0.01081177
38	PRKCA	0.00988461
39	ERBB4	0.00467503
40	ZAK	0.00285610
41	PRKACG	-0.1147102
42	MAP2K7	-0.1146519
43	FLT3	-0.1132980
44	MAPK13	-0.1121722
45	MAP4K1	-0.1120819
46	IKBKE	-0.1115833
47	TNK2	-0.1114993
48	TGFBR1	-0.1113314
49	PIM1	-0.1084748
50	PASK	-0.1078058
51	LYN	-0.1074500
52	PIK3CA	-0.1069802
53	PRKG1	-0.1067738
54	DAPK3	-0.1018435
55	MAPK14	-0.1007641
56	BTK	-0.0982393
57	BMPR1B	-0.0978459
58	BCKDK	-0.0954294
59	STK16	-0.0954117
60	BLK	-0.0948541
61	SYK	-0.0947382
62	PKN1	-0.0947081
63	PRKCE	-0.0889413
64	TTN	-0.0878494
65	MYLK	-0.0876962
66	CAMK2G	-0.0872279
67	CCNB1	-0.0868367
68	CAMK2A	-0.0864364
69	CDK2	-0.0861612
70	GRK6	-0.0856745
71	FRK	-0.0850354
72	MST1R	-0.0826631
73	EPHA2	-0.0806650
74	PIM2	-0.0795454
75	ADRBK1	-0.0792389
76	EPHB2	-0.0788010
77	MAPKAPK5	-0.0787236
78	MAP2K6	-0.0786536
79	PINK1	-0.0742847
80	DDR2	-0.0741548
81	STK39	-0.0715813
82	NTRK2	-0.0637562
83	LMTK2	-0.0621058
84	VRK1	-0.0616436
85	PRKCG	-0.0589269
86	ITK	-0.0513970
87	KIT	-0.0479208
88	TEC	-0.0469276
89	OXSR1	-0.0454606
90	MATK	-0.0398887
91	SRC	-0.0339280
92	KDR	-0.0337746
93	PHKG1	-0.0337655
94	PHKG2	-0.0337655
95	EPHA4	-0.0315938
96	WNK4	-0.0309997
97	GRK5	-0.0262853
98	PRKACA	-0.0210437
99	PLK4	-0.0096670
100	PRKCB	-0.0081275

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	8.48586739
2	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	7.19455723
3	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.32602783
4	RNA polymerase_Homo sapiens_hsa03020	3.17487465
5	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	3.12531179
6	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	3.01984494
7	Taste transduction_Homo sapiens_hsa04742	2.97189114
8	Fatty acid elongation_Homo sapiens_hsa00062	2.87153108
9	Lysine degradation_Homo sapiens_hsa00310	2.59637851
10	Butanoate metabolism_Homo sapiens_hsa00650	2.48003783
11	Proteasome_Homo sapiens_hsa03050	2.03404453
12	beta-Alanine metabolism_Homo sapiens_hsa00410	1.99725406
13	One carbon pool by folate_Homo sapiens_hsa00670	1.87691020
14	Tryptophan metabolism_Homo sapiens_hsa00380	1.82865081
15	Glycerolipid metabolism_Homo sapiens_hsa00561	1.81521914
16	Amoebiasis_Homo sapiens_hsa05146	1.74333060
17	Propanoate metabolism_Homo sapiens_hsa00640	1.68152768
18	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.28366593
19	Fatty acid degradation_Homo sapiens_hsa00071	1.19326911
20	Viral myocarditis_Homo sapiens_hsa05416	1.15014309
21	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	1.11062230
22	Fatty acid metabolism_Homo sapiens_hsa01212	0.98331595
23	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.93897156
24	Peroxisome_Homo sapiens_hsa04146	0.90199986
25	Complement and coagulation cascades_Homo sapiens_hsa04610	0.90037534
26	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.75336449
27	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.68532722
28	Pyrimidine metabolism_Homo sapiens_hsa00240	0.64154285
29	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.63914273
30	Caffeine metabolism_Homo sapiens_hsa00232	0.63635026
31	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.61928081
32	AMPK signaling pathway_Homo sapiens_hsa04152	0.60996201
33	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.59885700
34	Asthma_Homo sapiens_hsa05310	0.58747684
35	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.54860572
36	Nucleotide excision repair_Homo sapiens_hsa03420	0.53590246
37	MicroRNAs in cancer_Homo sapiens_hsa05206	0.52453693
38	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.51931923
39	Retinol metabolism_Homo sapiens_hsa00830	0.51214016
40	Olfactory transduction_Homo sapiens_hsa04740	0.51087110
41	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.50048749
42	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.49987290
43	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.49695125
44	Nicotine addiction_Homo sapiens_hsa05033	0.47770931
45	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.47532541
46	Allograft rejection_Homo sapiens_hsa05330	0.46266887
47	Cholinergic synapse_Homo sapiens_hsa04725	0.45996796
48	Graft-versus-host disease_Homo sapiens_hsa05332	0.45531783
49	Salmonella infection_Homo sapiens_hsa05132	0.45492116
50	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.43227161
51	Linoleic acid metabolism_Homo sapiens_hsa00591	0.39374453
52	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.39241778
53	Type I diabetes mellitus_Homo sapiens_hsa04940	0.37833562
54	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.37774078
55	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.37589046
56	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.37345782
57	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.37249455
58	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.36711302
59	Choline metabolism in cancer_Homo sapiens_hsa05231	0.35691755
60	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.35678830
61	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.34759541
62	Fat digestion and absorption_Homo sapiens_hsa04975	0.33986375
63	Chemical carcinogenesis_Homo sapiens_hsa05204	0.33944334
64	RNA transport_Homo sapiens_hsa03013	0.33722147
65	GnRH signaling pathway_Homo sapiens_hsa04912	0.33714995
66	Purine metabolism_Homo sapiens_hsa00230	0.33204707
67	Phototransduction_Homo sapiens_hsa04744	0.31214530
68	TNF signaling pathway_Homo sapiens_hsa04668	0.31078394
69	Nitrogen metabolism_Homo sapiens_hsa00910	0.30119601
70	Toxoplasmosis_Homo sapiens_hsa05145	0.30082493
71	Malaria_Homo sapiens_hsa05144	0.26630565
72	Tyrosine metabolism_Homo sapiens_hsa00350	0.25845558
73	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.25140354
74	Protein digestion and absorption_Homo sapiens_hsa04974	0.24969289
75	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.23962929
76	Primary immunodeficiency_Homo sapiens_hsa05340	0.23577755
77	Phagosome_Homo sapiens_hsa04145	0.22584625
78	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.22210005
79	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.19937455
80	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.19649925
81	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.17927700
82	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.16080377
83	ECM-receptor interaction_Homo sapiens_hsa04512	0.15188405
84	Phenylalanine metabolism_Homo sapiens_hsa00360	0.14495838
85	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.13401376
86	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.13239114
87	Metabolic pathways_Homo sapiens_hsa01100	0.13232327
88	African trypanosomiasis_Homo sapiens_hsa05143	0.12601790
89	Rheumatoid arthritis_Homo sapiens_hsa05323	0.12365438
90	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.12164378
91	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.11479919
92	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.10734687
93	Bile secretion_Homo sapiens_hsa04976	0.07721789
94	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.07528254
95	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.07079933
96	Tuberculosis_Homo sapiens_hsa05152	0.06914619
97	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.06668304
98	MAPK signaling pathway_Homo sapiens_hsa04010	0.05413816
99	Rap1 signaling pathway_Homo sapiens_hsa04015	0.04534877
100	Renin-angiotensin system_Homo sapiens_hsa04614	0.03973663

GAPDHP40

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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