ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	negative regulation of Ras GTPase activity (GO:0034261)	8.94594934
2	positive regulation of mitotic sister chromatid separation (GO:1901970)	8.60451472
3	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	8.60451472
4	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	8.60451472
5	regulation of T cell tolerance induction (GO:0002664)	8.55748934
6	eosinophil chemotaxis (GO:0048245)	7.76122047
7	eosinophil migration (GO:0072677)	7.24599409
8	negative regulation of T cell receptor signaling pathway (GO:0050860)	7.17367757
9	regulation of tolerance induction (GO:0002643)	7.12244458
10	regulation of sister chromatid cohesion (GO:0007063)	7.02357429
11	vesicle fusion (GO:0006906)	6.95536487
12	positive regulation of mast cell activation involved in immune response (GO:0033008)	6.72599272
13	positive regulation of mast cell degranulation (GO:0043306)	6.72599272
14	negative regulation of peptidyl-threonine phosphorylation (GO:0010801)	6.53364709
15	L-fucose catabolic process (GO:0042355)	6.42590055
16	fucose catabolic process (GO:0019317)	6.42590055
17	L-fucose metabolic process (GO:0042354)	6.42590055
18	regulation of mononuclear cell migration (GO:0071675)	6.27986044
19	branch elongation of an epithelium (GO:0060602)	6.20374854
20	regulation of T cell cytokine production (GO:0002724)	6.00489726
21	negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)	5.88126820
22	catecholamine biosynthetic process (GO:0042423)	5.69928667
23	catechol-containing compound biosynthetic process (GO:0009713)	5.69928667
24	positive regulation of mast cell activation (GO:0033005)	5.48640949
25	positive regulation of chromosome segregation (GO:0051984)	5.04283603
26	T cell apoptotic process (GO:0070231)	5.02830119
27	positive regulation of myeloid leukocyte mediated immunity (GO:0002888)	5.01959234
28	negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)	5.01503946
29	cellular biogenic amine biosynthetic process (GO:0042401)	4.99794755
30	autophagic vacuole fusion (GO:0000046)	4.84098430
31	peptidyl-lysine dimethylation (GO:0018027)	4.79682865
32	amine biosynthetic process (GO:0009309)	4.73336099
33	angiotensin maturation (GO:0002003)	4.70632857
34	protein targeting to vacuole (GO:0006623)	4.66238664
35	protein targeting to lysosome (GO:0006622)	4.66238664
36	establishment of protein localization to vacuole (GO:0072666)	4.66238664
37	axis elongation (GO:0003401)	4.59206243
38	regulation of nitric-oxide synthase biosynthetic process (GO:0051769)	4.54296880
39	positive regulation of leukocyte degranulation (GO:0043302)	4.54149984
40	macrophage chemotaxis (GO:0048246)	4.41739724
41	regulation of T cell receptor signaling pathway (GO:0050856)	4.40182453
42	regulation of mast cell activation involved in immune response (GO:0033006)	4.36839625
43	regulation of beta-amyloid formation (GO:1902003)	4.34039159
44	ribosomal small subunit assembly (GO:0000028)	4.31346201
45	lymphocyte apoptotic process (GO:0070227)	4.29610615
46	organ growth (GO:0035265)	4.25276103
47	monocyte chemotaxis (GO:0002548)	4.14784090
48	coenzyme A biosynthetic process (GO:0015937)	4.11499209
49	oxidative demethylation (GO:0070989)	4.04049113
50	positive regulation of calcium ion import (GO:0090280)	4.02797510
51	DNA dealkylation (GO:0035510)	3.96938485
52	metallo-sulfur cluster assembly (GO:0031163)	3.89953131
53	iron-sulfur cluster assembly (GO:0016226)	3.89953131
54	organelle membrane fusion (GO:0090174)	3.82194384
55	negative regulation of GTP catabolic process (GO:0033125)	3.80494154
56	negative regulation of GTPase activity (GO:0034260)	3.80494154
57	establishment of mitotic spindle orientation (GO:0000132)	3.75263917
58	organelle fusion (GO:0048284)	3.74354681
59	histone H3-K9 methylation (GO:0051567)	3.72275563
60	localization within membrane (GO:0051668)	3.71153611
61	detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)	3.70203558
62	replication fork processing (GO:0031297)	3.65992994
63	regulation of mast cell activation (GO:0033003)	3.58653862
64	leukocyte apoptotic process (GO:0071887)	3.58245482
65	non-recombinational repair (GO:0000726)	3.57419146
66	double-strand break repair via nonhomologous end joining (GO:0006303)	3.57419146
67	DNA demethylation (GO:0080111)	3.54940586
68	fucosylation (GO:0036065)	3.50741857
69	3-UTR-mediated mRNA stabilization (GO:0070935)	3.48411591
70	negative regulation of mast cell activation (GO:0033004)	3.48242028
71	protein import into peroxisome matrix (GO:0016558)	3.43522983
72	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	3.41739871
73	histone H3-K9 modification (GO:0061647)	3.41149275
74	positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)	3.40937173
75	regulation of antigen receptor-mediated signaling pathway (GO:0050854)	3.39602806
76	acrosome assembly (GO:0001675)	3.36217971
77	positive regulation of regulated secretory pathway (GO:1903307)	3.31076854
78	negative regulation of circadian rhythm (GO:0042754)	3.30773247
79	DNA integration (GO:0015074)	3.24711223
80	phenol-containing compound biosynthetic process (GO:0046189)	3.23860967
81	regulation of mast cell degranulation (GO:0043304)	3.22973677
82	seminiferous tubule development (GO:0072520)	3.16918011
83	establishment of spindle orientation (GO:0051294)	3.16890003
84	detection of chemical stimulus involved in sensory perception of taste (GO:0050912)	3.15547087
85	regulation of activated T cell proliferation (GO:0046006)	3.15391039
86	establishment of mitotic spindle localization (GO:0040001)	3.15170077
87	regulation of amyloid precursor protein catabolic process (GO:1902991)	3.14133483
88	protein localization to lysosome (GO:0061462)	3.13713548
89	protein localization to vacuole (GO:0072665)	3.13713548
90	urate metabolic process (GO:0046415)	3.08497682
91	single-organism membrane fusion (GO:0044801)	3.04217398
92	centriole replication (GO:0007099)	3.03485727
93	regulation of autophagic vacuole assembly (GO:2000785)	3.03321401
94	fucose metabolic process (GO:0006004)	3.01710169
95	regulation of hexokinase activity (GO:1903299)	2.97348497
96	regulation of glucokinase activity (GO:0033131)	2.97348497
97	peroxisome fission (GO:0016559)	2.95296248
98	imidazole-containing compound metabolic process (GO:0052803)	13.4578362
99	prenylation (GO:0097354)	10.5052584
100	protein prenylation (GO:0018342)	10.5052584

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	9.16866917
2	GATA1_22025678_ChIP-Seq_K562_Human	6.69662885
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	5.52761210
4	VDR_22108803_ChIP-Seq_LS180_Human	4.81834844
5	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	4.41301058
6	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	4.01063500
7	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.90895474
8	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.93837886
9	AR_21572438_ChIP-Seq_LNCaP_Human	2.62928279
10	IRF1_19129219_ChIP-ChIP_H3396_Human	2.52983586
11	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.36867577
12	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.00447551
13	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.94362505
14	RXR_22108803_ChIP-Seq_LS180_Human	1.88945875
15	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.76869656
16	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.71188596
17	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.69223620
18	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.66829266
19	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.65533448
20	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.64347346
21	BCAT_22108803_ChIP-Seq_LS180_Human	1.60953932
22	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.58531111
23	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.56820620
24	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.56820620
25	RUNX_20019798_ChIP-Seq_JUKART_Human	1.56450004
26	GBX2_23144817_ChIP-Seq_PC3_Human	1.55035338
27	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.49430520
28	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.43986534
29	TAF15_26573619_Chip-Seq_HEK293_Human	1.41540098
30	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.40947890
31	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.40813474
32	ZNF274_21170338_ChIP-Seq_K562_Hela	1.40490214
33	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.40357157
34	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.33631104
35	TP53_22573176_ChIP-Seq_HFKS_Human	1.28245195
36	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.25904265
37	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.19875221
38	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.18979766
39	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.17509160
40	MYB_21317192_ChIP-Seq_ERMYB_Mouse	1.16768881
41	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.16048880
42	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.15218610
43	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.14649249
44	ZIC3_20872845_ChIP-ChIP_MESCs_Mouse	1.14604845
45	P300_19829295_ChIP-Seq_ESCs_Human	1.13233408
46	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	1.11771873
47	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.10664095
48	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.10405148
49	TP53_16413492_ChIP-PET_HCT116_Human	1.09096328
50	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.08045938
51	IGF1R_20145208_ChIP-Seq_DFB_Human	1.05996251
52	CBP_20019798_ChIP-Seq_JUKART_Human	1.03485320
53	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.03485320
54	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.00668758
55	FUS_26573619_Chip-Seq_HEK293_Human	0.99096922
56	GATA3_26560356_Chip-Seq_TH1_Human	0.97812523
57	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.94859173
58	NANOG_19829295_ChIP-Seq_ESCs_Human	0.94687798
59	SOX2_19829295_ChIP-Seq_ESCs_Human	0.94687798
60	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.94558016
61	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	0.93954376
62	KLF4_18555785_Chip-Seq_ESCs_Mouse	0.93047125
63	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.92999688
64	SOX2_18555785_Chip-Seq_ESCs_Mouse	0.92507951
65	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.92484833
66	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.89975690
67	STAT3_23295773_ChIP-Seq_U87_Human	0.89602390
68	TBX3_20139965_ChIP-Seq_ESCs_Mouse	0.89453237
69	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.89238812
70	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.89238812
71	ZFX_18555785_Chip-Seq_ESCs_Mouse	0.88954596
72	TBX3_20139965_ChIP-Seq_MESCs_Mouse	0.88152852
73	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.87613666
74	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.87429384
75	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.86381210
76	SMAD1_18555785_Chip-Seq_ESCs_Mouse	0.86132447
77	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.86101473
78	DROSHA_22980978_ChIP-Seq_HELA_Human	0.85022041
79	ER_23166858_ChIP-Seq_MCF-7_Human	0.83048386
80	NMYC_18555785_Chip-Seq_ESCs_Mouse	0.82969520
81	P300_18555785_Chip-Seq_ESCs_Mouse	0.82382268
82	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.81088653
83	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.80753329
84	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.79700106
85	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.79082353
86	OCT4_20526341_ChIP-Seq_ESCs_Human	0.78162718
87	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	0.77667577
88	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.77391877
89	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.76250583
90	VDR_24787735_ChIP-Seq_THP-1_Human	0.76219788
91	NANOG_20526341_ChIP-Seq_ESCs_Human	0.76084139
92	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.75384552
93	P53_22387025_ChIP-Seq_ESCs_Mouse	0.75238597
94	TCF4_22108803_ChIP-Seq_LS180_Human	0.75223050
95	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.74833282
96	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.74324877
97	OCT4_18555785_Chip-Seq_ESCs_Mouse	0.73338979
98	SALL1_21062744_ChIP-ChIP_HESCs_Human	0.72512335
99	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.72498932
100	PU1_27457419_Chip-Seq_LIVER_Mouse	0.72358446

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000566_synostosis	8.71998874
2	MP0003303_peritoneal_inflammation	7.42339561
3	MP0006082_CNS_inflammation	5.82640839
4	MP0002735_abnormal_chemical_nociception	4.68510063
5	MP0003195_calcinosis	2.86659989
6	MP0001663_abnormal_digestive_system	2.60365970
7	MP0001919_abnormal_reproductive_system	2.45377763
8	MP0005171_absent_coat_pigmentation	2.32701574
9	MP0002751_abnormal_autonomic_nervous	2.26389770
10	MP0001664_abnormal_digestion	2.25747687
11	MP0005075_abnormal_melanosome_morpholog	2.24096690
12	MP0000372_irregular_coat_pigmentation	2.23947313
13	MP0000467_abnormal_esophagus_morphology	2.21723125
14	MP0005076_abnormal_cell_differentiation	2.14692889
15	MP0001873_stomach_inflammation	2.08871339
16	MP0008961_abnormal_basal_metabolism	2.07377063
17	MP0000383_abnormal_hair_follicle	2.07264573
18	MP0008058_abnormal_DNA_repair	1.93527999
19	MP0003283_abnormal_digestive_organ	1.84748881
20	MP0003115_abnormal_respiratory_system	1.81840945
21	MP0005381_digestive/alimentary_phenotyp	1.80542152
22	MP0002734_abnormal_mechanical_nocicepti	1.63804635
23	MP0008995_early_reproductive_senescence	1.61843949
24	MP0002971_abnormal_brown_adipose	1.57615845
25	MP0003136_yellow_coat_color	1.55784865
26	MP0005389_reproductive_system_phenotype	1.54970382
27	MP0005503_abnormal_tendon_morphology	1.48810364
28	MP0009115_abnormal_fat_cell	1.48575640
29	MP0006054_spinal_hemorrhage	1.46028572
30	MP0002733_abnormal_thermal_nociception	1.43246576
31	MP0003638_abnormal_response/metabolism_	1.42633844
32	MP0002876_abnormal_thyroid_physiology	1.40394964
33	MP0005166_decreased_susceptibility_to	1.37738141
34	MP0001915_intracranial_hemorrhage	1.37443109
35	MP0002148_abnormal_hypersensitivity_rea	1.30395403
36	MP0002405_respiratory_system_inflammati	1.28690010
37	MP0001348_abnormal_lacrimal_gland	1.26536178
38	MP0010678_abnormal_skin_adnexa	1.25189544
39	MP0001545_abnormal_hematopoietic_system	1.23771245
40	MP0005397_hematopoietic_system_phenotyp	1.23771245
41	MP0003763_abnormal_thymus_physiology	1.23597478
42	MP0003183_abnormal_peptide_metabolism	1.22755919
43	MP0005448_abnormal_energy_balance	1.19625464
44	MP0006276_abnormal_autonomic_nervous	1.12589770
45	MP0003453_abnormal_keratinocyte_physiol	0.99357784
46	MP0001970_abnormal_pain_threshold	0.94861515
47	MP0005501_abnormal_skin_physiology	0.92422396
48	MP0009840_abnormal_foam_cell	0.91156660
49	MP0005647_abnormal_sex_gland	0.90137767
50	MP0005083_abnormal_biliary_tract	0.85269612
51	MP0000465_gastrointestinal_hemorrhage	0.85116167
52	MP0002102_abnormal_ear_morphology	0.83654667
53	MP0002254_reproductive_system_inflammat	0.82358078
54	MP0005197_abnormal_uvea_morphology	0.82356244
55	MP0000733_abnormal_muscle_development	0.80088272
56	MP0005387_immune_system_phenotype	0.78854131
57	MP0001790_abnormal_immune_system	0.78854131
58	MP0009763_increased_sensitivity_to	0.78254898
59	MP0003937_abnormal_limbs/digits/tail_de	0.77825701
60	MP0002970_abnormal_white_adipose	0.76486577
61	MP0009765_abnormal_xenobiotic_induced	0.76110198
62	MP0005334_abnormal_fat_pad	0.76078457
63	MP0005253_abnormal_eye_physiology	0.75868927
64	MP0008877_abnormal_DNA_methylation	0.72203219
65	MP0001286_abnormal_eye_development	0.71344457
66	MP0003787_abnormal_imprinting	0.69948337
67	MP0002127_abnormal_cardiovascular_syste	0.69696939
68	MP0002210_abnormal_sex_determination	0.68317598
69	MP0001800_abnormal_humoral_immune	0.63933755
70	MP0005174_abnormal_tail_pigmentation	0.63343218
71	MP0002184_abnormal_innervation	0.62945610
72	MP0008872_abnormal_physiological_respon	0.61969116
73	MP0002109_abnormal_limb_morphology	0.60835500
74	MP0003950_abnormal_plasma_membrane	0.59895639
75	MP0002638_abnormal_pupillary_reflex	0.59799434
76	MP0005332_abnormal_amino_acid	0.58093785
77	MP0002572_abnormal_emotion/affect_behav	0.57840914
78	MP0001764_abnormal_homeostasis	0.57176747
79	MP0000858_altered_metastatic_potential	0.55175890
80	MP0002452_abnormal_antigen_presenting	0.54376391
81	MP0002019_abnormal_tumor_incidence	0.53521960
82	MP0001819_abnormal_immune_cell	0.53454568
83	MP0002420_abnormal_adaptive_immunity	0.53283110
84	MP0000371_diluted_coat_color	0.52803471
85	MP0001986_abnormal_taste_sensitivity	0.52234338
86	MP0004381_abnormal_hair_follicle	0.51734567
87	MP0002136_abnormal_kidney_physiology	0.51729993
88	MP0000716_abnormal_immune_system	0.51173580
89	MP0005551_abnormal_eye_electrophysiolog	0.49646662
90	MP0002115_abnormal_skeleton_extremities	0.49437427
91	MP0001293_anophthalmia	0.49334868
92	MP0002398_abnormal_bone_marrow	0.49294055
93	MP0000428_abnormal_craniofacial_morphol	0.49279495
94	MP0000534_abnormal_ureter_morphology	0.48804037
95	MP0002722_abnormal_immune_system	0.47081973
96	MP0001963_abnormal_hearing_physiology	0.45970704
97	MP0000470_abnormal_stomach_morphology	0.45021521
98	MP0004484_altered_response_of	0.44201924
99	MP0001175_abnormal_lung_morphology	0.43110249
100	MP0001119_abnormal_female_reproductive	0.43079098

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Duplicated collecting system (HP:0000081)	8.24397127
2	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	8.11852558
3	Abnormality of the renal collecting system (HP:0004742)	7.53188002
4	Adactyly (HP:0009776)	5.74591596
5	Large for gestational age (HP:0001520)	5.70066694
6	Long foot (HP:0001833)	5.59253547
7	Male infertility (HP:0003251)	5.57514765
8	Abnormality of fatty-acid metabolism (HP:0004359)	5.11643063
9	Acute lymphatic leukemia (HP:0006721)	5.09832968
10	Steatorrhea (HP:0002570)	5.05805283
11	Dry hair (HP:0011359)	4.94076408
12	Hypoplastic pelvis (HP:0008839)	4.89857623
13	Decreased lacrimation (HP:0000633)	4.74889063
14	Failure to thrive in infancy (HP:0001531)	4.58527727
15	Ureteral duplication (HP:0000073)	4.26060597
16	Pulmonary artery stenosis (HP:0004415)	4.10055942
17	Fat malabsorption (HP:0002630)	3.86947030
18	Autoamputation (HP:0001218)	3.78673181
19	Ureteral obstruction (HP:0006000)	3.60483128
20	Severe muscular hypotonia (HP:0006829)	3.56599850
21	Palmoplantar hyperkeratosis (HP:0000972)	3.54598385
22	Progressive muscle weakness (HP:0003323)	3.48415685
23	Ureteral stenosis (HP:0000071)	3.46728910
24	Palmar hyperkeratosis (HP:0010765)	3.36658587
25	Increased number of teeth (HP:0011069)	3.35240194
26	Broad-based gait (HP:0002136)	3.30116106
27	Rhinitis (HP:0012384)	3.23945198
28	Hypoplastic nipples (HP:0002557)	3.20789143
29	Menstrual irregularities (HP:0000858)	3.09158187
30	Anhidrosis (HP:0000970)	3.03441366
31	Abnormal auditory evoked potentials (HP:0006958)	2.97392788
32	Broad nasal tip (HP:0000455)	2.87372255
33	Brushfield spots (HP:0001088)	2.86788483
34	Abnormality of vision evoked potentials (HP:0000649)	2.84844611
35	Clubbing of toes (HP:0100760)	2.82760035
36	Recurrent sinusitis (HP:0011108)	2.79502707
37	Sudden death (HP:0001699)	2.72281654
38	Plantar hyperkeratosis (HP:0007556)	2.71385349
39	Hypophosphatemic rickets (HP:0004912)	2.69129564
40	Autoimmune thrombocytopenia (HP:0001973)	2.66703862
41	Abnormal ventriculo-arterial connection (HP:0011563)	2.63597568
42	Transposition of the great arteries (HP:0001669)	2.63597568
43	Abnormal connection of the cardiac segments (HP:0011545)	2.63597568
44	Intrahepatic cholestasis (HP:0001406)	2.47062585
45	Polymicrogyria (HP:0002126)	2.45590476
46	Polyneuropathy (HP:0001271)	2.39197578
47	Basal ganglia calcification (HP:0002135)	2.38322678
48	Premature graying of hair (HP:0002216)	2.38021845
49	Steppage gait (HP:0003376)	2.37157760
50	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.36806319
51	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.34809371
52	Myoglobinuria (HP:0002913)	2.30797631
53	Orthostatic hypotension (HP:0001278)	2.30460349
54	Alveolar cell carcinoma (HP:0006519)	2.30388506
55	Recurrent corneal erosions (HP:0000495)	2.21564518
56	Widely spaced teeth (HP:0000687)	2.17109003
57	Papilledema (HP:0001085)	2.16473898
58	Decreased muscle mass (HP:0003199)	2.15912636
59	Reduced subcutaneous adipose tissue (HP:0003758)	2.13693094
60	Wide intermamillary distance (HP:0006610)	2.13319252
61	Neoplasm of the tracheobronchial system (HP:0100552)	2.04126974
62	Episodic fever (HP:0001954)	2.02897086
63	Rhabdomyolysis (HP:0003201)	2.01053153
64	Flat face (HP:0012368)	1.98074174
65	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	1.94811977
66	Hypoplastic iliac wings (HP:0002866)	1.92617265
67	Alacrima (HP:0000522)	1.91321543
68	Stereotypic behavior (HP:0000733)	1.89643491
69	Polydipsia (HP:0001959)	1.88436500
70	Abnormal drinking behavior (HP:0030082)	1.88436500
71	Overfolded helix (HP:0000396)	1.88051882
72	Metabolic acidosis (HP:0001942)	1.87602679
73	Abnormality of T cell physiology (HP:0011840)	1.87270769
74	Recurrent cutaneous fungal infections (HP:0011370)	1.82559041
75	Chronic mucocutaneous candidiasis (HP:0002728)	1.82559041
76	Gangrene (HP:0100758)	1.82401321
77	Epiphyseal stippling (HP:0010655)	1.80460360
78	Chorioretinal coloboma (HP:0000567)	1.78879270
79	Impaired proprioception (HP:0010831)	1.78315150
80	Aplasia/Hypoplasia of the nipples (HP:0006709)	1.77407717
81	Bronchiectasis (HP:0002110)	1.75458952
82	Cellular immunodeficiency (HP:0005374)	1.75248953
83	Retinopathy (HP:0000488)	1.72849456
84	Postnatal growth retardation (HP:0008897)	1.72091555
85	Congenital onset (HP:0003577)	1.70864971
86	Abnormality of the basal ganglia (HP:0002134)	1.69953809
87	Anxiety (HP:0000739)	1.65376986
88	Pustule (HP:0200039)	1.63314537
89	IgG deficiency (HP:0004315)	1.63137040
90	Attenuation of retinal blood vessels (HP:0007843)	1.62504294
91	Autoimmune hemolytic anemia (HP:0001890)	1.56878744
92	Nail dystrophy (HP:0008404)	1.56806775
93	Infertility (HP:0000789)	1.56716185
94	Congenital stationary night blindness (HP:0007642)	1.56306668
95	Arterial thrombosis (HP:0004420)	1.55201306
96	Primary adrenal insufficiency (HP:0008207)	1.54223664
97	Abnormally folded helix (HP:0008544)	1.53672789
98	Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)	1.52356774
99	Rough bone trabeculation (HP:0100670)	1.52295556
100	Albinism (HP:0001022)	1.51879845

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TAOK1	6.21422700
2	MKNK1	6.02909964
3	TAOK2	5.12954602
4	TRIM28	4.98313603
5	MAP3K3	3.30092160
6	MAP3K11	3.16937665
7	MAP2K3	3.09924669
8	MKNK2	10.3041840
9	JAK3	1.97294483
10	DYRK1A	1.58947677
11	ABL2	1.51029011
12	FRK	1.48810079
13	TNIK	1.26730586
14	FER	1.06300298
15	MAP3K5	1.01037661
16	MAP4K2	0.90558177
17	WNK3	0.73027812
18	MAP3K1	0.67569485
19	BCKDK	0.63239020
20	PDK2	0.63067903
21	CHEK2	0.62629357
22	GRK6	0.61463679
23	PRKCQ	0.60087083
24	ADRBK2	0.59197720
25	GRK1	0.58469307
26	MARK3	0.53304798
27	STK24	0.47016949
28	MATK	0.43656177
29	SRPK1	0.42767503
30	INSRR	0.41616973
31	TIE1	0.41195245
32	SIK3	0.38199774
33	PRKD2	0.38021244
34	GRK7	0.35792798
35	DAPK2	0.34763872
36	CAMKK2	0.33989715
37	IRAK3	0.33221907
38	MAP4K1	0.32857606
39	IKBKE	0.27749305
40	EPHA4	0.27490983
41	OBSCN	0.24822053
42	IRAK4	0.24086548
43	TGFBR2	0.23552449
44	CSF1R	0.22968283
45	CHUK	0.22412755
46	MAP3K8	0.22219534
47	ACVR1B	0.21283582
48	PKN1	0.20734996
49	MAPK13	0.20174047
50	FES	0.19898555
51	ABL1	0.19516651
52	MAP3K4	0.18254307
53	MAP2K7	0.17648922
54	ADRBK1	0.17519938
55	IGF1R	0.17258038
56	STK39	0.17215992
57	PAK3	0.16151615
58	PNCK	0.16096798
59	GRK5	0.15532814
60	LYN	0.15038771
61	CSNK1A1	0.14860300
62	TNK2	0.13687981
63	GSK3A	0.13341055
64	PRKCE	0.12995253
65	TXK	0.12931152
66	BMPR1B	0.12776866
67	WNK4	0.12758998
68	ERBB3	0.12728065
69	PIM1	0.11888362
70	PRKACA	0.11316066
71	EPHA3	0.11233693
72	MARK2	0.09773120
73	ERBB2	0.09379838
74	INSR	0.08992804
75	PRKCA	0.08834281
76	PRKCI	0.08823098
77	SYK	0.08338405
78	PRKCD	0.08068703
79	PLK2	0.07752248
80	PRPF4B	0.07234225
81	IKBKB	0.06686400
82	PRKCB	0.05949258
83	MAP3K2	0.05773115
84	PRKCH	0.05259465
85	CSNK2A1	0.05089373
86	PIK3CG	0.04412804
87	TEC	0.04062362
88	LCK	0.03785203
89	BTK	0.03498004
90	CASK	0.02861103
91	CAMKK1	0.02695584
92	PTK2B	0.02352967
93	STK16	0.02350667
94	STK10	0.01991282
95	JAK2	0.01896550
96	BRSK2	0.01865774
97	EGFR	0.01804057
98	CSNK1E	0.01614444
99	WNK1	0.00672972
100	KIT	-0.0014427

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	6.39055010
2	Histidine metabolism_Homo sapiens_hsa00340	5.26798901
3	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	4.48559785
4	Asthma_Homo sapiens_hsa05310	4.11886831
5	Renin-angiotensin system_Homo sapiens_hsa04614	3.71975391
6	Taste transduction_Homo sapiens_hsa04742	2.53939557
7	Butanoate metabolism_Homo sapiens_hsa00650	2.37789894
8	Caffeine metabolism_Homo sapiens_hsa00232	2.31660142
9	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	2.17738974
10	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.09105552
11	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.73411847
12	RNA polymerase_Homo sapiens_hsa03020	1.68596819
13	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.65610817
14	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.63835836
15	Other glycan degradation_Homo sapiens_hsa00511	1.58789647
16	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.57373091
17	Lysine degradation_Homo sapiens_hsa00310	1.47288610
18	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.46830579
19	Peroxisome_Homo sapiens_hsa04146	1.43257556
20	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.36155613
21	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.30640798
22	Glycerolipid metabolism_Homo sapiens_hsa00561	1.27673501
23	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.23183064
24	Olfactory transduction_Homo sapiens_hsa04740	1.20504160
25	Linoleic acid metabolism_Homo sapiens_hsa00591	1.10386956
26	Tryptophan metabolism_Homo sapiens_hsa00380	1.08733586
27	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.04668668
28	Nitrogen metabolism_Homo sapiens_hsa00910	0.99370263
29	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.97439194
30	Phototransduction_Homo sapiens_hsa04744	0.97094274
31	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.96953632
32	Pancreatic secretion_Homo sapiens_hsa04972	0.94331080
33	Chemical carcinogenesis_Homo sapiens_hsa05204	0.89897621
34	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.89829391
35	Fatty acid degradation_Homo sapiens_hsa00071	0.89672718
36	Protein digestion and absorption_Homo sapiens_hsa04974	0.85580981
37	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.84945090
38	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.84072981
39	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.83882826
40	Retinol metabolism_Homo sapiens_hsa00830	0.82484311
41	beta-Alanine metabolism_Homo sapiens_hsa00410	0.80544614
42	Primary immunodeficiency_Homo sapiens_hsa05340	0.80019496
43	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.78644044
44	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.75389497
45	Nucleotide excision repair_Homo sapiens_hsa03420	0.74928543
46	Complement and coagulation cascades_Homo sapiens_hsa04610	0.73942687
47	Propanoate metabolism_Homo sapiens_hsa00640	0.70662889
48	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.69358073
49	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.68052882
50	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.62730896
51	Oocyte meiosis_Homo sapiens_hsa04114	0.62082460
52	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.60939405
53	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.58291927
54	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.57081971
55	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.56397636
56	Fatty acid elongation_Homo sapiens_hsa00062	0.56252984
57	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.56151115
58	Amoebiasis_Homo sapiens_hsa05146	0.53337618
59	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.52323905
60	Fat digestion and absorption_Homo sapiens_hsa04975	0.51895942
61	Fanconi anemia pathway_Homo sapiens_hsa03460	0.51816171
62	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.50759951
63	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.49215250
64	Choline metabolism in cancer_Homo sapiens_hsa05231	0.47583765
65	Fatty acid metabolism_Homo sapiens_hsa01212	0.47225729
66	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.46955156
67	Dopaminergic synapse_Homo sapiens_hsa04728	0.46525689
68	Ether lipid metabolism_Homo sapiens_hsa00565	0.45592260
69	Nicotine addiction_Homo sapiens_hsa05033	0.43854125
70	Homologous recombination_Homo sapiens_hsa03440	0.42521855
71	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.42447063
72	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.42093428
73	ABC transporters_Homo sapiens_hsa02010	0.42046782
74	AMPK signaling pathway_Homo sapiens_hsa04152	0.40169510
75	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.39827664
76	Allograft rejection_Homo sapiens_hsa05330	0.39262317
77	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.36140369
78	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.35273220
79	Cholinergic synapse_Homo sapiens_hsa04725	0.34314075
80	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.33410912
81	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.33375180
82	Morphine addiction_Homo sapiens_hsa05032	0.33160868
83	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.32906675
84	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.30685395
85	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.28777657
86	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.28707498
87	One carbon pool by folate_Homo sapiens_hsa00670	0.27215893
88	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.24538912
89	Long-term depression_Homo sapiens_hsa04730	0.24270448
90	Calcium signaling pathway_Homo sapiens_hsa04020	0.22974806
91	Viral myocarditis_Homo sapiens_hsa05416	0.22705188
92	Salivary secretion_Homo sapiens_hsa04970	0.22567890
93	GnRH signaling pathway_Homo sapiens_hsa04912	0.22140447
94	African trypanosomiasis_Homo sapiens_hsa05143	0.21726834
95	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.19994176
96	Cocaine addiction_Homo sapiens_hsa05030	0.17152722
97	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.16612859
98	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.16284275
99	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.14009623
100	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.12542900

GAPDHP42

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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