GAPDHP44

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1eosinophil chemotaxis (GO:0048245)8.54531067
2prenylation (GO:0097354)8.09579446
3protein prenylation (GO:0018342)8.09579446
4ribosomal small subunit assembly (GO:0000028)7.78941652
5positive regulation of mitotic sister chromatid separation (GO:1901970)7.77237101
6positive regulation of mitotic metaphase/anaphase transition (GO:0045842)7.77237101
7positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)7.77237101
8eosinophil migration (GO:0072677)7.70012037
9negative regulation of Ras GTPase activity (GO:0034261)7.13028626
10negative regulation of T cell receptor signaling pathway (GO:0050860)6.81654953
11L-fucose catabolic process (GO:0042355)6.08927349
12fucose catabolic process (GO:0019317)6.08927349
13L-fucose metabolic process (GO:0042354)6.08927349
14regulation of mononuclear cell migration (GO:0071675)6.06857410
15proteasome assembly (GO:0043248)5.76318043
16regulation of sister chromatid cohesion (GO:0007063)5.45189145
17negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)5.43028622
18macrophage chemotaxis (GO:0048246)5.24859409
19negative regulation of peptidyl-threonine phosphorylation (GO:0010801)5.22205887
20cytidine deamination (GO:0009972)5.18385258
21cytidine metabolic process (GO:0046087)5.18385258
22cytidine catabolic process (GO:0006216)5.18385258
23DNA deamination (GO:0045006)5.09395156
24positive regulation of chromosome segregation (GO:0051984)5.06774417
25branch elongation of an epithelium (GO:0060602)4.81366153
26vesicle fusion (GO:0006906)4.67186417
27negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)4.66873386
28coenzyme A biosynthetic process (GO:0015937)4.64914148
29autophagic vacuole fusion (GO:0000046)4.61507447
30regulation of T cell receptor signaling pathway (GO:0050856)4.56073092
31pyrimidine ribonucleoside catabolic process (GO:0046133)4.36334410
32regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.10353284
33localization within membrane (GO:0051668)4.09092463
34mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.09010817
35energy coupled proton transport, down electrochemical gradient (GO:0015985)4.05741015
36ATP synthesis coupled proton transport (GO:0015986)4.05741015
37organelle membrane fusion (GO:0090174)3.91795718
38detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)3.90818655
39monocyte chemotaxis (GO:0002548)3.88585328
40positive regulation of calcium ion import (GO:0090280)3.85401253
41DNA demethylation (GO:0080111)3.81754970
42non-recombinational repair (GO:0000726)3.78914230
43double-strand break repair via nonhomologous end joining (GO:0006303)3.78914230
44regulation of cellular amino acid metabolic process (GO:0006521)3.78063104
45positive chemotaxis (GO:0050918)3.77911526
46preassembly of GPI anchor in ER membrane (GO:0016254)3.75787791
47organ growth (GO:0035265)3.72835834
48oxidative demethylation (GO:0070989)3.70131646
49protein import into peroxisome matrix (GO:0016558)3.69462425
50iron-sulfur cluster assembly (GO:0016226)3.64114789
51metallo-sulfur cluster assembly (GO:0031163)3.64114789
52DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.60606512
53mitochondrial respiratory chain complex I assembly (GO:0032981)3.59469798
54NADH dehydrogenase complex assembly (GO:0010257)3.59469798
55mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.59469798
56negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.58310502
57chaperone-mediated protein transport (GO:0072321)3.53188825
58termination of RNA polymerase III transcription (GO:0006386)3.52772954
59transcription elongation from RNA polymerase III promoter (GO:0006385)3.52772954
60protein complex biogenesis (GO:0070271)3.48950146
61signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.48814891
62intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.48814891
63signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.46866474
64signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.46866474
65signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.46866474
66signal transduction involved in DNA integrity checkpoint (GO:0072401)3.43219289
67signal transduction involved in DNA damage checkpoint (GO:0072422)3.43219289
68establishment of protein localization to mitochondrial membrane (GO:0090151)3.40669623
69pantothenate metabolic process (GO:0015939)3.39636967
70DNA integration (GO:0015074)3.38738818
71signal transduction involved in cell cycle checkpoint (GO:0072395)3.38468591
72detection of chemical stimulus involved in sensory perception of taste (GO:0050912)3.36857845
73mitochondrial respiratory chain complex assembly (GO:0033108)3.27544404
74mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.27390389
75positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.24498908
76DNA dealkylation (GO:0035510)3.24314452
77regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.23973221
78protein neddylation (GO:0045116)3.21773325
79regulation of autophagic vacuole assembly (GO:2000785)3.20772665
80peptidyl-lysine dimethylation (GO:0018027)3.17623308
81seminiferous tubule development (GO:0072520)3.16418217
82respiratory electron transport chain (GO:0022904)3.14375765
83negative regulation of ligase activity (GO:0051352)3.14246128
84negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.14246128
85GPI anchor biosynthetic process (GO:0006506)3.11566789
86electron transport chain (GO:0022900)3.08797004
87fucosylation (GO:0036065)3.07881634
88axis elongation (GO:0003401)3.07327995
89regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.05011142
90intracellular protein transmembrane import (GO:0044743)3.04853069
91regulation of T cell apoptotic process (GO:0070232)2.98748598
92organelle fusion (GO:0048284)2.96258474
93antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.95593007
94membrane budding (GO:0006900)2.89528999
95regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.86110478
96regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.84268967
97fucose metabolic process (GO:0006004)2.84088938
98regulation of beta-amyloid formation (GO:1902003)2.83230417
99RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.83146221
100tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.83146221

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse6.71003508
2GATA1_22025678_ChIP-Seq_K562_Human5.95245150
3VDR_22108803_ChIP-Seq_LS180_Human5.02699848
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.70088661
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.96688826
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.51964779
7ELF1_17652178_ChIP-ChIP_JURKAT_Human3.14708599
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.89737401
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.88969269
10YY1_21170310_ChIP-Seq_MESCs_Mouse2.87650557
11CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.72795929
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.67935011
13NOTCH1_21737748_ChIP-Seq_TLL_Human2.65302258
14RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.61483074
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.59238523
16SRF_21415370_ChIP-Seq_HL-1_Mouse2.58654255
17BP1_19119308_ChIP-ChIP_Hs578T_Human2.41002751
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.30517249
19VDR_23849224_ChIP-Seq_CD4+_Human2.16626306
20CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.09286981
21PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse2.03676991
22MYC_18555785_ChIP-Seq_MESCs_Mouse1.95459424
23ELK1_19687146_ChIP-ChIP_HELA_Human1.90235722
24SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.86972860
25FLI1_27457419_Chip-Seq_LIVER_Mouse1.85152548
26IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.76596508
27FOXP3_21729870_ChIP-Seq_TREG_Human1.70961897
28SRY_22984422_ChIP-ChIP_TESTIS_Rat1.69244440
29HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.69148276
30CREB1_15753290_ChIP-ChIP_HEK293T_Human1.66969473
31IRF1_19129219_ChIP-ChIP_H3396_Human1.66058733
32POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.57071826
33AR_21572438_ChIP-Seq_LNCaP_Human1.56256498
34ZNF274_21170338_ChIP-Seq_K562_Hela1.53588581
35MYC_18358816_ChIP-ChIP_MESCs_Mouse1.53431756
36EGR1_23403033_ChIP-Seq_LIVER_Mouse1.51481358
37GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48968187
38IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.47810589
39PCGF2_27294783_Chip-Seq_ESCs_Mouse1.44798672
40HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.38382298
41ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.37212622
42TP53_22573176_ChIP-Seq_HFKS_Human1.28092881
43E2F4_17652178_ChIP-ChIP_JURKAT_Human1.25979635
44DCP1A_22483619_ChIP-Seq_HELA_Human1.23714692
45THAP11_20581084_ChIP-Seq_MESCs_Mouse1.23705783
46CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.21997587
47BCAT_22108803_ChIP-Seq_LS180_Human1.20013351
48TAF15_26573619_Chip-Seq_HEK293_Human1.19329954
49MYC_19030024_ChIP-ChIP_MESCs_Mouse1.18460466
50POU5F1_16153702_ChIP-ChIP_HESCs_Human1.17205143
51MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.16828202
52E2F1_18555785_ChIP-Seq_MESCs_Mouse1.13431446
53ZFP57_27257070_Chip-Seq_ESCs_Mouse1.11485894
54TTF2_22483619_ChIP-Seq_HELA_Human1.10889005
55GABP_19822575_ChIP-Seq_HepG2_Human1.10107991
56FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.08854182
57PCGF2_27294783_Chip-Seq_NPCs_Mouse1.06650227
58ERG_20517297_ChIP-Seq_VCAP_Human1.04257404
59RXR_22108803_ChIP-Seq_LS180_Human1.02040595
60FUS_26573619_Chip-Seq_HEK293_Human1.01918335
61FOXA1_25329375_ChIP-Seq_VCAP_Human1.01300443
62FOXA1_27270436_Chip-Seq_PROSTATE_Human1.01300443
63ELK1_22589737_ChIP-Seq_MCF10A_Human0.99665324
64PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.99160328
65CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.99124046
66ZNF263_19887448_ChIP-Seq_K562_Human0.98544623
67HOXB4_20404135_ChIP-ChIP_EML_Mouse0.96285671
68MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.94904915
69KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.93616492
70NANOG_20526341_ChIP-Seq_ESCs_Human0.92097026
71CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.91307962
72HTT_18923047_ChIP-ChIP_STHdh_Human0.91286689
73FOXH1_21741376_ChIP-Seq_EPCs_Human0.90019453
74MYC_18940864_ChIP-ChIP_HL60_Human0.89600862
75GATA3_26560356_Chip-Seq_TH1_Human0.89424894
76TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86933136
77STAT4_19710469_ChIP-ChIP_TH1__Mouse0.86748986
78HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.85007456
79EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.84866466
80SOX2_19829295_ChIP-Seq_ESCs_Human0.84619589
81NANOG_19829295_ChIP-Seq_ESCs_Human0.84619589
82IRF8_22096565_ChIP-ChIP_GC-B_Human0.83665262
83PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.82673971
84EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.82200311
85P300_19829295_ChIP-Seq_ESCs_Human0.82130500
86NANOG_16153702_ChIP-ChIP_HESCs_Human0.81564273
87TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.79501689
88IKZF1_21737484_ChIP-ChIP_HCT116_Human0.79002689
89AR_20517297_ChIP-Seq_VCAP_Human0.78055998
90CTBP1_25329375_ChIP-Seq_LNCAP_Human0.77015827
91RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.76769822
92FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.76425052
93STAT1_20625510_ChIP-Seq_HELA_Human0.75276606
94GATA3_21878914_ChIP-Seq_MCF-7_Human0.74462501
95STAT3_1855785_ChIP-Seq_MESCs_Mouse0.74233645
96SUZ12_27294783_Chip-Seq_NPCs_Mouse0.74194648
97NCOR_22424771_ChIP-Seq_293T_Human0.73324417
98ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.73091942
99PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.72890407
100TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.72715931

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis9.03538616
2MP0003303_peritoneal_inflammation5.48432551
3MP0006082_CNS_inflammation4.16065899
4MP0005671_abnormal_response_to2.81131943
5MP0001919_abnormal_reproductive_system2.51226370
6MP0001663_abnormal_digestive_system2.41008881
7MP0001664_abnormal_digestion2.39024884
8MP0002876_abnormal_thyroid_physiology2.33332856
9MP0002751_abnormal_autonomic_nervous2.10965466
10MP0004145_abnormal_muscle_electrophysio2.07496414
11MP0002138_abnormal_hepatobiliary_system2.06475155
12MP0005389_reproductive_system_phenotype2.05305627
13MP0000467_abnormal_esophagus_morphology1.99828923
14MP0002102_abnormal_ear_morphology1.85070373
15MP0005381_digestive/alimentary_phenotyp1.76269892
16MP0005645_abnormal_hypothalamus_physiol1.74436153
17MP0005166_decreased_susceptibility_to1.61891079
18MP0001905_abnormal_dopamine_level1.55584809
19MP0003937_abnormal_limbs/digits/tail_de1.45460683
20MP0001764_abnormal_homeostasis1.37436442
21MP0005360_urolithiasis1.33165272
22MP0008872_abnormal_physiological_respon1.31296680
23MP0006072_abnormal_retinal_apoptosis1.31259407
24MP0001968_abnormal_touch/_nociception1.28638887
25MP0001529_abnormal_vocalization1.27874139
26MP0002736_abnormal_nociception_after1.27087981
27MP0000372_irregular_coat_pigmentation1.25767279
28MP0003806_abnormal_nucleotide_metabolis1.25263513
29MP0003763_abnormal_thymus_physiology1.25057846
30MP0009785_altered_susceptibility_to1.24473187
31MP0010155_abnormal_intestine_physiology1.23558204
32MP0001293_anophthalmia1.23310355
33MP0008875_abnormal_xenobiotic_pharmacok1.22878273
34MP0000685_abnormal_immune_system1.18438629
35MP0005085_abnormal_gallbladder_physiolo1.17466200
36MP0003115_abnormal_respiratory_system1.16371172
37MP0000490_abnormal_crypts_of1.11748347
38MP0000383_abnormal_hair_follicle1.11047890
39MP0005253_abnormal_eye_physiology1.08906427
40MP0000534_abnormal_ureter_morphology1.08621511
41MP0005083_abnormal_biliary_tract1.07263098
42MP0009333_abnormal_splenocyte_physiolog1.04401785
43MP0003638_abnormal_response/metabolism_1.03728238
44MP0005084_abnormal_gallbladder_morpholo1.03094108
45MP0002139_abnormal_hepatobiliary_system1.02811822
46MP0002837_dystrophic_cardiac_calcinosis1.02004900
47MP0002163_abnormal_gland_morphology1.01118998
48MP0009379_abnormal_foot_pigmentation0.95565665
49MP0002277_abnormal_respiratory_mucosa0.95474074
50MP0004019_abnormal_vitamin_homeostasis0.94894688
51MP0001835_abnormal_antigen_presentation0.93845398
52MP0003718_maternal_effect0.93303682
53MP0008058_abnormal_DNA_repair0.92438086
54MP0001963_abnormal_hearing_physiology0.91602883
55MP0002166_altered_tumor_susceptibility0.91511205
56MP0002006_tumorigenesis0.90820585
57MP0002019_abnormal_tumor_incidence0.89723027
58MP0001485_abnormal_pinna_reflex0.89669061
59MP0000026_abnormal_inner_ear0.87719350
60MP0005377_hearing/vestibular/ear_phenot0.87669568
61MP0003878_abnormal_ear_physiology0.87669568
62MP0002210_abnormal_sex_determination0.87022690
63MP0004147_increased_porphyrin_level0.86896783
64MP0002938_white_spotting0.85137745
65MP0006292_abnormal_olfactory_placode0.84479150
66MP0009697_abnormal_copulation0.83942771
67MP0004142_abnormal_muscle_tone0.83081638
68MP0003252_abnormal_bile_duct0.81469417
69MP0000477_abnormal_intestine_morphology0.81315865
70MP0002160_abnormal_reproductive_system0.81232951
71MP0003959_abnormal_lean_body0.80869964
72MP0005332_abnormal_amino_acid0.80628587
73MP0004885_abnormal_endolymph0.80496657
74MP0001800_abnormal_humoral_immune0.79260025
75MP0009763_increased_sensitivity_to0.77844691
76MP0001790_abnormal_immune_system0.77474157
77MP0005387_immune_system_phenotype0.77474157
78MP0002109_abnormal_limb_morphology0.75764126
79MP0006276_abnormal_autonomic_nervous0.75671888
80MP0001501_abnormal_sleep_pattern0.75155018
81MP0005025_abnormal_response_to0.74819150
82MP0002148_abnormal_hypersensitivity_rea0.74587057
83MP0009745_abnormal_behavioral_response0.71271078
84MP0003866_abnormal_defecation0.70414288
85MP0000049_abnormal_middle_ear0.69915703
86MP0000358_abnormal_cell_content/0.69630679
87MP0001119_abnormal_female_reproductive0.68074096
88MP0002735_abnormal_chemical_nociception0.67261412
89MP0009764_decreased_sensitivity_to0.67001756
90MP0003786_premature_aging0.66224987
91MP0002115_abnormal_skeleton_extremities0.65850850
92MP0003646_muscle_fatigue0.65073192
93MP0009643_abnormal_urine_homeostasis0.64495647
94MP0002733_abnormal_thermal_nociception0.63560217
95MP0005000_abnormal_immune_tolerance0.62838430
96MP0002272_abnormal_nervous_system0.61791731
97MP0005551_abnormal_eye_electrophysiolog0.59900218
98MP0006036_abnormal_mitochondrial_physio0.59085192
99MP0001286_abnormal_eye_development0.58833799
100MP0002420_abnormal_adaptive_immunity0.58619093

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of long-chain fatty-acid metabolism (HP:0010964)7.16718386
2Duplicated collecting system (HP:0000081)5.48702367
3Abnormality of the renal collecting system (HP:0004742)5.22748791
4Abnormality of fatty-acid metabolism (HP:0004359)4.58771884
5Large for gestational age (HP:0001520)4.39513832
6Adactyly (HP:0009776)4.29424770
7Long foot (HP:0001833)4.23176524
8Hypoplastic pelvis (HP:0008839)4.22505182
9Dry hair (HP:0011359)4.15826875
10Acute necrotizing encephalopathy (HP:0006965)4.03060210
11Mitochondrial inheritance (HP:0001427)3.99616540
12Reduced subcutaneous adipose tissue (HP:0003758)3.71459489
13Hepatocellular necrosis (HP:0001404)3.70599182
14Abnormal mitochondria in muscle tissue (HP:0008316)3.63221802
15Hepatic necrosis (HP:0002605)3.52382535
16Acute encephalopathy (HP:0006846)3.51166420
17Progressive muscle weakness (HP:0003323)3.49207017
18Increased CSF lactate (HP:0002490)3.42157914
19Progressive macrocephaly (HP:0004481)3.35003665
20Lactic acidosis (HP:0003128)3.34731857
21Brushfield spots (HP:0001088)3.24324860
22Menstrual irregularities (HP:0000858)3.17552157
23Ureteral duplication (HP:0000073)3.16387239
24Ureteral stenosis (HP:0000071)3.13122227
25Steatorrhea (HP:0002570)2.99595761
26Acute lymphatic leukemia (HP:0006721)2.97408277
27Broad-based gait (HP:0002136)2.96017806
28Severe muscular hypotonia (HP:0006829)2.90875729
29Increased serum lactate (HP:0002151)2.82389654
303-Methylglutaconic aciduria (HP:0003535)2.80915764
31Ureteral obstruction (HP:0006000)2.79667238
32Increased hepatocellular lipid droplets (HP:0006565)2.72732710
33Renal Fanconi syndrome (HP:0001994)2.72217068
34Rhabdomyolysis (HP:0003201)2.71244932
35Cerebral edema (HP:0002181)2.68959975
36Respiratory failure (HP:0002878)2.68107378
37Autoamputation (HP:0001218)2.63447819
38Myoglobinuria (HP:0002913)2.62942906
39Lipid accumulation in hepatocytes (HP:0006561)2.61721088
40Pulmonary artery stenosis (HP:0004415)2.61654960
41Exercise intolerance (HP:0003546)2.59101383
42Fat malabsorption (HP:0002630)2.56061292
43Oral leukoplakia (HP:0002745)2.48821391
44CNS demyelination (HP:0007305)2.46558050
45Decreased lacrimation (HP:0000633)2.38359776
46Anhidrosis (HP:0000970)2.38087238
47Abnormal auditory evoked potentials (HP:0006958)2.34628721
48Optic disc pallor (HP:0000543)2.31752329
49Aplastic anemia (HP:0001915)2.31630216
50Hypoproteinemia (HP:0003075)2.31613692
51Congenital, generalized hypertrichosis (HP:0004540)2.28442919
52Metabolic acidosis (HP:0001942)2.24960051
53Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.22196792
54Abolished electroretinogram (ERG) (HP:0000550)2.17914535
55Hypoplastic nipples (HP:0002557)2.17437066
56Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.16464623
57Decreased activity of mitochondrial respiratory chain (HP:0008972)2.16464623
58Increased intramyocellular lipid droplets (HP:0012240)2.12830304
59Decreased electroretinogram (ERG) amplitude (HP:0000654)2.11928181
60Abnormality of urine glucose concentration (HP:0011016)2.07483744
61Glycosuria (HP:0003076)2.07483744
62Increased IgM level (HP:0003496)2.05763393
63Chorioretinal coloboma (HP:0000567)2.05630237
64Polyneuropathy (HP:0001271)2.04495997
65Epiphyseal stippling (HP:0010655)2.04268558
66Palpebral edema (HP:0100540)2.03990443
67Wide intermamillary distance (HP:0006610)1.98868114
68Abnormality of the phalanges of the 2nd finger (HP:0009541)1.98805062
69Congenital stationary night blindness (HP:0007642)1.97409159
70Abnormal number of erythroid precursors (HP:0012131)1.96646098
71Sudden death (HP:0001699)1.95923057
72Clubbing of toes (HP:0100760)1.94233847
73Absent rod-and cone-mediated responses on ERG (HP:0007688)1.93909660
74IgG deficiency (HP:0004315)1.92458264
75Conjunctival hamartoma (HP:0100780)1.92379005
76Generalized aminoaciduria (HP:0002909)1.91141129
77Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.90763533
78Aplasia/hypoplasia of the uterus (HP:0008684)1.88869946
79Hypoplasia of the uterus (HP:0000013)1.82267471
80Pancreatic fibrosis (HP:0100732)1.79586759
81Leukodystrophy (HP:0002415)1.78378316
82Abnormality of renal resorption (HP:0011038)1.77587796
83Exertional dyspnea (HP:0002875)1.76559613
84Pancreatic cysts (HP:0001737)1.76332229
85Increased muscle lipid content (HP:0009058)1.76173551
86Female pseudohermaphroditism (HP:0010458)1.74644161
87Abnormality of the proximal phalanges of the hand (HP:0009834)1.72945397
88Abnormal rod and cone electroretinograms (HP:0008323)1.72714472
89Lethargy (HP:0001254)1.71044477
90Elevated erythrocyte sedimentation rate (HP:0003565)1.70068077
91Polymicrogyria (HP:0002126)1.69024966
92Abnormality of cells of the erythroid lineage (HP:0012130)1.68632497
93Decreased muscle mass (HP:0003199)1.64881038
94Type I transferrin isoform profile (HP:0003642)1.63089657
95Transposition of the great arteries (HP:0001669)1.61986221
96Abnormal connection of the cardiac segments (HP:0011545)1.61986221
97Abnormal ventriculo-arterial connection (HP:0011563)1.61986221
98Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.61985896
99Severe combined immunodeficiency (HP:0004430)1.61683248
100Increased number of teeth (HP:0011069)1.61342572

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MKNK29.75228463
2MKNK15.96558754
3TAOK24.45512129
4TAOK14.15286873
5MAP3K113.52074381
6MAP3K32.87221098
7VRK22.58538719
8MAP2K32.50598446
9JAK32.02102376
10KDR1.79903283
11ABL21.76127779
12BUB11.71468316
13SRPK11.70919184
14ZAK1.45772759
15TLK11.45661865
16TIE11.40307957
17VRK11.39806864
18TESK21.37158049
19MAP4K21.35328293
20DYRK1A1.33120055
21BCKDK1.22307727
22NUAK11.22208805
23TAF11.12357047
24CDK191.04222127
25MAP3K121.01910467
26WNK41.00990173
27TXK0.95373016
28CHEK20.93439404
29MAP3K50.89079289
30ADRBK20.89022971
31CSNK1G30.78368748
32NME20.75582186
33GRK10.73710874
34PRKCQ0.66586657
35CSNK1G10.63594046
36NEK10.61865364
37CSNK1G20.59273495
38GRK70.58794278
39CSNK1A1L0.57330523
40PHKG10.57223683
41PHKG20.57223683
42OXSR10.56678784
43TRIM280.54745601
44AURKA0.54577301
45DAPK10.53881527
46OBSCN0.53545141
47STK390.53018641
48MYLK0.51721195
49LIMK10.51498097
50STK160.47488048
51WNK30.47077593
52CSNK1A10.46609039
53RPS6KA50.46438810
54INSRR0.46128899
55FRK0.45443444
56BMPR1B0.43288645
57TESK10.42808860
58DAPK30.41203815
59MAP3K80.40873653
60DYRK20.39381946
61CDC70.36554355
62PDK20.35712027
63MAP3K10.35103937
64TEC0.33991581
65PLK30.31600758
66GRK50.30070650
67CSNK2A10.29389385
68CSNK2A20.28528539
69MAPKAPK30.28100194
70MUSK0.27007282
71PINK10.26359430
72EIF2AK30.25337953
73MAPKAPK50.24626908
74PIK3CG0.24511412
75BCR0.24508364
76PLK40.22837167
77PIK3CA0.22568279
78TNIK0.22006541
79NME10.21864961
80ITK0.21329491
81MAP4K10.20752920
82PRKCD0.19627901
83PLK20.19382038
84PRKCA0.19102126
85MAP2K70.17694655
86PRKACA0.17667317
87ADRBK10.16861552
88IGF1R0.16283100
89ATR0.16198338
90MST40.13732922
91PIM20.12549591
92TAOK30.12283329
93BLK0.12206585
94IKBKB0.11375103
95EPHB20.11289913
96KIT0.10736593
97CAMK2G0.09554735
98CSNK1E0.09429112
99ABL10.08727863
100PRKCG0.08491039

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.10963487
2SNARE interactions in vesicular transport_Homo sapiens_hsa041303.76087824
3Oxidative phosphorylation_Homo sapiens_hsa001903.33846179
4RNA polymerase_Homo sapiens_hsa030202.97673727
5Parkinsons disease_Homo sapiens_hsa050122.81169459
6Ribosome_Homo sapiens_hsa030102.71004057
7Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.68884610
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.45628945
9Huntingtons disease_Homo sapiens_hsa050162.07600764
10Protein export_Homo sapiens_hsa030602.01499244
11Alzheimers disease_Homo sapiens_hsa050101.97495216
12Systemic lupus erythematosus_Homo sapiens_hsa053221.83318897
13Primary immunodeficiency_Homo sapiens_hsa053401.72767825
14Fatty acid elongation_Homo sapiens_hsa000621.71229849
15Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.61907808
16Asthma_Homo sapiens_hsa053101.60384259
17Cardiac muscle contraction_Homo sapiens_hsa042601.53699876
18Butanoate metabolism_Homo sapiens_hsa006501.50340132
19Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.49697631
20Graft-versus-host disease_Homo sapiens_hsa053321.48786570
21Autoimmune thyroid disease_Homo sapiens_hsa053201.35525318
22Taste transduction_Homo sapiens_hsa047421.35244940
23Allograft rejection_Homo sapiens_hsa053301.34816652
24One carbon pool by folate_Homo sapiens_hsa006701.34492789
25Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.29378379
26Antigen processing and presentation_Homo sapiens_hsa046121.27601232
27Pyrimidine metabolism_Homo sapiens_hsa002401.26977761
28Type I diabetes mellitus_Homo sapiens_hsa049401.25950939
29Propanoate metabolism_Homo sapiens_hsa006401.25881505
30Intestinal immune network for IgA production_Homo sapiens_hsa046721.25580125
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.24211772
32Peroxisome_Homo sapiens_hsa041461.22426640
33Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.11101120
34Tryptophan metabolism_Homo sapiens_hsa003801.10818187
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.10707495
36Maturity onset diabetes of the young_Homo sapiens_hsa049501.09364411
37Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.08278591
38Caffeine metabolism_Homo sapiens_hsa002321.07713342
39Cyanoamino acid metabolism_Homo sapiens_hsa004600.96750209
40Sulfur metabolism_Homo sapiens_hsa009200.96392183
41Fat digestion and absorption_Homo sapiens_hsa049750.93015380
42Chemical carcinogenesis_Homo sapiens_hsa052040.92042069
43Nitrogen metabolism_Homo sapiens_hsa009100.88781157
44Purine metabolism_Homo sapiens_hsa002300.86857207
45DNA replication_Homo sapiens_hsa030300.85947699
46Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.84634413
47RNA transport_Homo sapiens_hsa030130.83714979
48Fatty acid degradation_Homo sapiens_hsa000710.82848476
49Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.81399648
50Alcoholism_Homo sapiens_hsa050340.81254326
51Mismatch repair_Homo sapiens_hsa034300.79868637
52Rheumatoid arthritis_Homo sapiens_hsa053230.79005552
53Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.78342520
54Nucleotide excision repair_Homo sapiens_hsa034200.78234880
55Linoleic acid metabolism_Homo sapiens_hsa005910.77524788
562-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.75898488
57Glutathione metabolism_Homo sapiens_hsa004800.74639980
58beta-Alanine metabolism_Homo sapiens_hsa004100.74458474
59Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.72847562
60Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.72404248
61Homologous recombination_Homo sapiens_hsa034400.71637265
62Retinol metabolism_Homo sapiens_hsa008300.71515524
63Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.70614090
64Viral myocarditis_Homo sapiens_hsa054160.69617446
65Pentose and glucuronate interconversions_Homo sapiens_hsa000400.66261142
66RNA degradation_Homo sapiens_hsa030180.65968445
67Vitamin digestion and absorption_Homo sapiens_hsa049770.64892077
68Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.64888085
69Carbon metabolism_Homo sapiens_hsa012000.63698183
70Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.63265717
71Folate biosynthesis_Homo sapiens_hsa007900.62633556
72Metabolic pathways_Homo sapiens_hsa011000.61569344
73alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.60371015
74Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.59661713
75Drug metabolism - other enzymes_Homo sapiens_hsa009830.57882298
76Hematopoietic cell lineage_Homo sapiens_hsa046400.57832160
77Arginine biosynthesis_Homo sapiens_hsa002200.55935628
78Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.55253555
79Spliceosome_Homo sapiens_hsa030400.55161101
80Sulfur relay system_Homo sapiens_hsa041220.55089338
81Glycerolipid metabolism_Homo sapiens_hsa005610.54314646
82Steroid hormone biosynthesis_Homo sapiens_hsa001400.52443068
83Primary bile acid biosynthesis_Homo sapiens_hsa001200.51925709
84Phototransduction_Homo sapiens_hsa047440.51835539
85Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.49829453
86Cysteine and methionine metabolism_Homo sapiens_hsa002700.48996130
87Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.48700580
88Epstein-Barr virus infection_Homo sapiens_hsa051690.47957520
89Base excision repair_Homo sapiens_hsa034100.46681719
90Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.44354679
91Basal transcription factors_Homo sapiens_hsa030220.43581874
92Fanconi anemia pathway_Homo sapiens_hsa034600.42457344
93Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.41957573
94Fatty acid metabolism_Homo sapiens_hsa012120.39664853
95Transcriptional misregulation in cancer_Homo sapiens_hsa052020.38664465
96Biosynthesis of amino acids_Homo sapiens_hsa012300.37974208
97Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.37882841
98Renin-angiotensin system_Homo sapiens_hsa046140.37260331
99Nicotine addiction_Homo sapiens_hsa050330.37178348
100Arachidonic acid metabolism_Homo sapiens_hsa005900.37114927

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