GAPDHP46

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.99886949
2establishment of protein localization to mitochondrial membrane (GO:0090151)5.53550900
3thalamus development (GO:0021794)5.08190457
4cytidine metabolic process (GO:0046087)4.86939371
5cytidine catabolic process (GO:0006216)4.86939371
6cytidine deamination (GO:0009972)4.86939371
7RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.66930889
8tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.66930889
9mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.66051912
10mitochondrial respiratory chain complex I assembly (GO:0032981)4.66051912
11NADH dehydrogenase complex assembly (GO:0010257)4.66051912
12protein neddylation (GO:0045116)4.60255600
13protein complex biogenesis (GO:0070271)4.55557645
14mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.54535822
15ATP synthesis coupled proton transport (GO:0015986)4.46920567
16energy coupled proton transport, down electrochemical gradient (GO:0015985)4.46920567
17response to gravity (GO:0009629)4.42965355
18regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.36955967
19mitochondrial respiratory chain complex assembly (GO:0033108)4.36383468
20negative regulation of thymocyte apoptotic process (GO:0070244)4.22445495
21cullin deneddylation (GO:0010388)3.98164122
22chaperone-mediated protein transport (GO:0072321)3.86817953
23mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.81501348
24pyrimidine ribonucleoside catabolic process (GO:0046133)3.74892643
25negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.71220590
26nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.67484505
27DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.66161467
28signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.60358589
29signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.60358589
30signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.60358589
31polyamine biosynthetic process (GO:0006596)3.58414730
32protein deneddylation (GO:0000338)3.56978557
33signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.56417058
34intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.56417058
35exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.53993066
36regulation of cellular amino acid metabolic process (GO:0006521)3.49543059
37respiratory electron transport chain (GO:0022904)3.49508255
38signal transduction involved in DNA integrity checkpoint (GO:0072401)3.45081043
39signal transduction involved in DNA damage checkpoint (GO:0072422)3.45081043
40electron transport chain (GO:0022900)3.44319328
41negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.43692342
42signal peptide processing (GO:0006465)3.42198686
43pseudouridine synthesis (GO:0001522)3.38944084
44signal transduction involved in cell cycle checkpoint (GO:0072395)3.37882665
45regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.34102076
46transcription elongation from RNA polymerase I promoter (GO:0006362)3.33972031
47skeletal muscle tissue regeneration (GO:0043403)3.32025020
48regulation of thymocyte apoptotic process (GO:0070243)3.31962047
49proteasome assembly (GO:0043248)3.25783856
50termination of RNA polymerase I transcription (GO:0006363)3.23201550
51maturation of 5.8S rRNA (GO:0000460)3.23152170
52transcription from RNA polymerase I promoter (GO:0006360)3.18218825
53water-soluble vitamin biosynthetic process (GO:0042364)3.17200192
54transcription initiation from RNA polymerase I promoter (GO:0006361)3.15205388
55nucleobase biosynthetic process (GO:0046112)3.09848354
56purine nucleobase biosynthetic process (GO:0009113)3.07669248
57positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.07456030
58skeletal muscle adaptation (GO:0043501)3.07118146
59regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.01500460
60negative regulation of ligase activity (GO:0051352)3.01077820
61negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.01077820
62positive regulation of endothelial cell differentiation (GO:0045603)2.95381895
63positive regulation of cell cycle arrest (GO:0071158)2.95070620
64transcription elongation from RNA polymerase III promoter (GO:0006385)2.93261648
65termination of RNA polymerase III transcription (GO:0006386)2.93261648
66intracellular protein transmembrane import (GO:0044743)2.91347158
67postreplication repair (GO:0006301)2.88313211
68DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.87983279
69folic acid-containing compound biosynthetic process (GO:0009396)2.87430989
70rRNA processing (GO:0006364)2.87164768
71protein K6-linked ubiquitination (GO:0085020)2.87161566
72DNA damage response, detection of DNA damage (GO:0042769)2.84680653
73anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.84366334
74regulation of centriole replication (GO:0046599)2.83683504
75response to muscle activity (GO:0014850)2.83367654
76antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.80897857
77IMP biosynthetic process (GO:0006188)2.80355851
78striated muscle atrophy (GO:0014891)2.79339933
79negative regulation of muscle hypertrophy (GO:0014741)2.76565533
80peptidyl-histidine modification (GO:0018202)2.75900332
81regulation of chronic inflammatory response (GO:0002676)2.75350354
82cellular biogenic amine biosynthetic process (GO:0042401)2.74750744
83rRNA metabolic process (GO:0016072)2.73492783
84maturation of SSU-rRNA (GO:0030490)2.71864010
85regulation of timing of cell differentiation (GO:0048505)2.69461132
86activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.67892996
87respiratory chain complex IV assembly (GO:0008535)2.67409888
88protein targeting to mitochondrion (GO:0006626)2.67223924
89inner mitochondrial membrane organization (GO:0007007)2.63865196
90rRNA modification (GO:0000154)2.63464943
91antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.62105109
92cytochrome complex assembly (GO:0017004)2.61188785
93actin-myosin filament sliding (GO:0033275)2.59720883
94muscle filament sliding (GO:0030049)2.59720883
95regulation of isotype switching to IgG isotypes (GO:0048302)2.58990437
96positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.57837465
97ATP biosynthetic process (GO:0006754)2.57721998
98muscle atrophy (GO:0014889)2.55810222
99negative regulation of heart rate (GO:0010459)2.54199753
100protein localization to mitochondrion (GO:0070585)2.54101013

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.10372311
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.52230145
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.47486163
4VDR_22108803_ChIP-Seq_LS180_Human4.10787021
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.64129153
6ELF1_17652178_ChIP-ChIP_JURKAT_Human3.48327870
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.96181095
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.79709155
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.73681005
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.73244980
11VDR_23849224_ChIP-Seq_CD4+_Human2.69042850
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.52608215
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.37437594
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.36868753
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.31795900
16PCGF2_27294783_Chip-Seq_ESCs_Mouse2.24325459
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.09725766
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.07596618
19IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.07342521
20E2F4_17652178_ChIP-ChIP_JURKAT_Human2.04171168
21ELK1_19687146_ChIP-ChIP_HELA_Human2.03573788
22PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.96199697
23E2F7_22180533_ChIP-Seq_HELA_Human1.88373005
24ZNF274_21170338_ChIP-Seq_K562_Hela1.80512457
25PCGF2_27294783_Chip-Seq_NPCs_Mouse1.80030950
26IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.77882202
27FOXP3_21729870_ChIP-Seq_TREG_Human1.73475998
28DCP1A_22483619_ChIP-Seq_HELA_Human1.69805720
29NOTCH1_21737748_ChIP-Seq_TLL_Human1.67978167
30TAF15_26573619_Chip-Seq_HEK293_Human1.67146094
31PADI4_21655091_ChIP-ChIP_MCF-7_Human1.66583778
32ER_23166858_ChIP-Seq_MCF-7_Human1.65369374
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.59670937
34EWS_26573619_Chip-Seq_HEK293_Human1.58470927
35EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.57098157
36AR_21572438_ChIP-Seq_LNCaP_Human1.54525182
37FUS_26573619_Chip-Seq_HEK293_Human1.52240482
38PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.51697099
39RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50687658
40FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.48941192
41SRF_21415370_ChIP-Seq_HL-1_Mouse1.48930486
42MYC_18555785_ChIP-Seq_MESCs_Mouse1.48265679
43MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.41602937
44IRF1_19129219_ChIP-ChIP_H3396_Human1.41084687
45AUTS2_25519132_ChIP-Seq_293T-REX_Human1.39118815
46THAP11_20581084_ChIP-Seq_MESCs_Mouse1.38760672
47ELK1_22589737_ChIP-Seq_MCF10A_Human1.37252026
48EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.36842750
49HOXB4_20404135_ChIP-ChIP_EML_Mouse1.35191293
50YY1_21170310_ChIP-Seq_MESCs_Mouse1.33783930
51TTF2_22483619_ChIP-Seq_HELA_Human1.33284098
52MYC_18940864_ChIP-ChIP_HL60_Human1.32287793
53EGR1_23403033_ChIP-Seq_LIVER_Mouse1.31200063
54FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.29971902
55P300_19829295_ChIP-Seq_ESCs_Human1.25992602
56TP53_22573176_ChIP-Seq_HFKS_Human1.22947164
57POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.22077943
58MYC_19030024_ChIP-ChIP_MESCs_Mouse1.20730911
59PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.19491259
60UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17265674
61IRF8_21731497_ChIP-ChIP_J774_Mouse1.15024011
62SUZ12_27294783_Chip-Seq_NPCs_Mouse1.14790584
63STAT4_19710469_ChIP-ChIP_TH1__Mouse1.14748600
64CTBP1_25329375_ChIP-Seq_LNCAP_Human1.13375277
65FOXA1_25329375_ChIP-Seq_VCAP_Human1.12693556
66FOXA1_27270436_Chip-Seq_PROSTATE_Human1.12693556
67ERG_20517297_ChIP-Seq_VCAP_Human1.07672681
68CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.06968820
69MYC_18358816_ChIP-ChIP_MESCs_Mouse1.06555385
70GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06250168
71GATA1_22025678_ChIP-Seq_K562_Human1.05511222
72MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.05338132
73AR_20517297_ChIP-Seq_VCAP_Human1.05298202
74GABP_19822575_ChIP-Seq_HepG2_Human1.05160243
75CTBP2_25329375_ChIP-Seq_LNCAP_Human1.03201416
76MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.02861379
77ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.02350832
78NFE2_27457419_Chip-Seq_LIVER_Mouse0.99795576
79HOXB7_26014856_ChIP-Seq_BT474_Human0.97261979
80PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95942654
81CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.94824210
82CDX2_22108803_ChIP-Seq_LS180_Human0.93691814
83FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.92033765
84POU5F1_16153702_ChIP-ChIP_HESCs_Human0.91564408
85EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.91323538
86CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.89804854
87EZH2_22144423_ChIP-Seq_EOC_Human0.87968914
88POU3F2_20337985_ChIP-ChIP_501MEL_Human0.87255227
89EZH2_27294783_Chip-Seq_NPCs_Mouse0.86979707
90NCOR_22424771_ChIP-Seq_293T_Human0.86189313
91MYC_19079543_ChIP-ChIP_MESCs_Mouse0.84881594
92NANOG_19829295_ChIP-Seq_ESCs_Human0.83522019
93SOX2_19829295_ChIP-Seq_ESCs_Human0.83522019
94LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.81807560
95CEBPB_22108803_ChIP-Seq_LS180_Human0.81742726
96TDRD3_21172665_ChIP-Seq_MCF-7_Human0.80042426
97TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.80024258
98FOXA1_21572438_ChIP-Seq_LNCaP_Human0.80006012
99YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.79539856
100NANOG_20526341_ChIP-Seq_ESCs_Human0.79535641

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005083_abnormal_biliary_tract4.01441813
2MP0005085_abnormal_gallbladder_physiolo3.62582460
3MP0004145_abnormal_muscle_electrophysio3.20964645
4MP0000566_synostosis2.89208778
5MP0002822_catalepsy2.85204422
6MP0001529_abnormal_vocalization2.63467134
7MP0000569_abnormal_digit_pigmentation2.54439226
8MP0002102_abnormal_ear_morphology2.50794610
9MP0005084_abnormal_gallbladder_morpholo2.44092623
10MP0003718_maternal_effect2.43888581
11MP0004142_abnormal_muscle_tone2.36764514
12MP0008872_abnormal_physiological_respon2.35848992
13MP0002138_abnormal_hepatobiliary_system2.26205930
14MP0002163_abnormal_gland_morphology2.25515527
15MP0003252_abnormal_bile_duct2.23013890
16MP0000749_muscle_degeneration2.19491092
17MP0000372_irregular_coat_pigmentation2.02987887
18MP0008875_abnormal_xenobiotic_pharmacok2.00423331
19MP0002736_abnormal_nociception_after1.91786428
20MP0001835_abnormal_antigen_presentation1.87223125
21MP0008004_abnormal_stomach_pH1.85219669
22MP0003186_abnormal_redox_activity1.84043652
23MP0004084_abnormal_cardiac_muscle1.81029302
24MP0003806_abnormal_nucleotide_metabolis1.79953165
25MP0004147_increased_porphyrin_level1.78331984
26MP0005645_abnormal_hypothalamus_physiol1.63799644
27MP0000490_abnormal_crypts_of1.62533210
28MP0002089_abnormal_postnatal_growth/wei1.59773961
29MP0003786_premature_aging1.55594280
30MP0004036_abnormal_muscle_relaxation1.54969662
31MP0000747_muscle_weakness1.53190333
32MP0009785_altered_susceptibility_to1.52802755
33MP0001873_stomach_inflammation1.47628501
34MP0003959_abnormal_lean_body1.47234034
35MP0002837_dystrophic_cardiac_calcinosis1.46247194
36MP0005671_abnormal_response_to1.44345030
37MP0005379_endocrine/exocrine_gland_phen1.43108135
38MP0004957_abnormal_blastocyst_morpholog1.41809369
39MP0005365_abnormal_bile_salt1.41081792
40MP0001968_abnormal_touch/_nociception1.36501759
41MP0002166_altered_tumor_susceptibility1.35843974
42MP0001348_abnormal_lacrimal_gland1.34206087
43MP0009697_abnormal_copulation1.28184170
44MP0005464_abnormal_platelet_physiology1.24369163
45MP0000685_abnormal_immune_system1.23266733
46MP0008569_lethality_at_weaning1.22386982
47MP0005670_abnormal_white_adipose1.21953956
48MP0005387_immune_system_phenotype1.18997238
49MP0001790_abnormal_immune_system1.18997238
50MP0002006_tumorigenesis1.17931680
51MP0003045_fibrosis1.17416948
52MP0003950_abnormal_plasma_membrane1.15887022
53MP0003693_abnormal_embryo_hatching1.10723445
54MP0005167_abnormal_blood-brain_barrier1.09689476
55MP0009745_abnormal_behavioral_response1.08904702
56MP0008057_abnormal_DNA_replication1.05601467
57MP0008877_abnormal_DNA_methylation1.05443861
58MP0002277_abnormal_respiratory_mucosa1.05294523
59MP0002733_abnormal_thermal_nociception1.00415211
60MP0005551_abnormal_eye_electrophysiolog1.00182297
61MP0002148_abnormal_hypersensitivity_rea1.00013968
62MP0006072_abnormal_retinal_apoptosis0.96118787
63MP0001800_abnormal_humoral_immune0.94505818
64MP0009333_abnormal_splenocyte_physiolog0.93739433
65MP0000427_abnormal_hair_cycle0.92970362
66MP0005620_abnormal_muscle_contractility0.91903073
67MP0006035_abnormal_mitochondrial_morpho0.91791767
68MP0000015_abnormal_ear_pigmentation0.89471582
69MP0001905_abnormal_dopamine_level0.86099048
70MP0009765_abnormal_xenobiotic_induced0.85449439
71MP0001666_abnormal_nutrient_absorption0.85007976
72MP0004215_abnormal_myocardial_fiber0.83953736
73MP0005075_abnormal_melanosome_morpholog0.82962518
74MP0003866_abnormal_defecation0.82707743
75MP0002234_abnormal_pharynx_morphology0.82046466
76MP0001664_abnormal_digestion0.81817862
77MP0002269_muscular_atrophy0.81622834
78MP0002095_abnormal_skin_pigmentation0.80975639
79MP0005636_abnormal_mineral_homeostasis0.79313781
80MP0005310_abnormal_salivary_gland0.76817489
81MP0009053_abnormal_anal_canal0.76608384
82MP0000477_abnormal_intestine_morphology0.74074421
83MP0008995_early_reproductive_senescence0.73276018
84MP0006036_abnormal_mitochondrial_physio0.73147876
85MP0001663_abnormal_digestive_system0.72706054
86MP0004381_abnormal_hair_follicle0.72001962
87MP0005646_abnormal_pituitary_gland0.71497569
88MP0001970_abnormal_pain_threshold0.71062018
89MP0010155_abnormal_intestine_physiology0.69394706
90MP0005584_abnormal_enzyme/coenzyme_acti0.69282574
91MP0005174_abnormal_tail_pigmentation0.69232054
92MP0001293_anophthalmia0.68988853
93MP0003077_abnormal_cell_cycle0.68098950
94MP0002272_abnormal_nervous_system0.67833668
95MP0003878_abnormal_ear_physiology0.66717970
96MP0005377_hearing/vestibular/ear_phenot0.66717970
97MP0002210_abnormal_sex_determination0.65937536
98MP0005395_other_phenotype0.64104367
99MP0009764_decreased_sensitivity_to0.63357662
100MP0010030_abnormal_orbit_morphology0.62188176

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.68087424
2Abnormal mitochondria in muscle tissue (HP:0008316)4.91662712
3Acute encephalopathy (HP:0006846)4.91428051
4Mitochondrial inheritance (HP:0001427)4.73698618
5Progressive macrocephaly (HP:0004481)4.70558121
6Palpebral edema (HP:0100540)4.48910989
7Increased CSF lactate (HP:0002490)4.25501419
8Hepatocellular necrosis (HP:0001404)4.14785827
9Hepatic necrosis (HP:0002605)4.05813857
103-Methylglutaconic aciduria (HP:0003535)3.75145265
11Cerebral edema (HP:0002181)3.22013067
12Congenital stationary night blindness (HP:0007642)3.14667387
13Increased hepatocellular lipid droplets (HP:0006565)3.14341707
14Congenital, generalized hypertrichosis (HP:0004540)3.09154329
15Generalized aminoaciduria (HP:0002909)3.05773274
16Hypoproteinemia (HP:0003075)2.94998446
17Increased serum lactate (HP:0002151)2.88538683
18Optic disc pallor (HP:0000543)2.84832223
19Exertional dyspnea (HP:0002875)2.84443695
20Stomatitis (HP:0010280)2.83418729
21Leukodystrophy (HP:0002415)2.73647064
22Respiratory failure (HP:0002878)2.72112149
23Renal Fanconi syndrome (HP:0001994)2.71957094
24Lipid accumulation in hepatocytes (HP:0006561)2.71818619
25Type II lissencephaly (HP:0007260)2.69244922
26Stenosis of the external auditory canal (HP:0000402)2.65891261
27Inability to walk (HP:0002540)2.63321338
28Exercise intolerance (HP:0003546)2.58554486
29Oligodactyly (hands) (HP:0001180)2.58393378
30Conjugated hyperbilirubinemia (HP:0002908)2.50571338
31IgG deficiency (HP:0004315)2.50268041
32Lactic acidosis (HP:0003128)2.44134410
33Abnormal pupillary function (HP:0007686)2.43003849
34Paralysis (HP:0003470)2.42174399
35Colon cancer (HP:0003003)2.38051824
36Neoplasm of the adrenal cortex (HP:0100641)2.36399866
37Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.32667897
38Abnormality of the renal cortex (HP:0011035)2.30785649
39Respiratory difficulties (HP:0002880)2.30307731
40Abnormality of the labia minora (HP:0012880)2.29863381
41Fair hair (HP:0002286)2.26353977
42Hypothermia (HP:0002045)2.25647017
43Periorbital edema (HP:0100539)2.24265497
44Methylmalonic aciduria (HP:0012120)2.24262293
45Absent phalangeal crease (HP:0006109)2.21907203
46Increased intramyocellular lipid droplets (HP:0012240)2.20535961
47Decreased activity of mitochondrial respiratory chain (HP:0008972)2.19666752
48Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.19666752
49Facial edema (HP:0000282)2.19479996
50Pendular nystagmus (HP:0012043)2.16834169
51Testicular atrophy (HP:0000029)2.14905576
52Aplasia/hypoplasia of the uterus (HP:0008684)2.12192081
53Palpitations (HP:0001962)2.11371214
54Myoglobinuria (HP:0002913)2.10431678
55Decreased electroretinogram (ERG) amplitude (HP:0000654)2.06810137
56Abnormal albumin level (HP:0012116)2.04932515
57Hypoalbuminemia (HP:0003073)2.04932515
58Absent rod-and cone-mediated responses on ERG (HP:0007688)2.04582931
59Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.04018416
60Gaze-evoked nystagmus (HP:0000640)2.01854204
61Abnormal hair whorl (HP:0010721)2.01498902
62Optic nerve hypoplasia (HP:0000609)1.98512217
63Abnormality of the pons (HP:0007361)1.97770090
64Elevated erythrocyte sedimentation rate (HP:0003565)1.96582036
65Petechiae (HP:0000967)1.95784202
662-3 toe syndactyly (HP:0004691)1.92713350
67Abnormality of purine metabolism (HP:0004352)1.91897515
68X-linked dominant inheritance (HP:0001423)1.91621590
69Abnormal rod and cone electroretinograms (HP:0008323)1.91400033
70Anterior segment dysgenesis (HP:0007700)1.91309403
71Molar tooth sign on MRI (HP:0002419)1.90646305
72Abnormality of midbrain morphology (HP:0002418)1.90646305
73Abnormal finger flexion creases (HP:0006143)1.90063270
74Muscle fiber atrophy (HP:0100295)1.89642214
75Hypoplasia of the pons (HP:0012110)1.88482681
76Abnormality of macular pigmentation (HP:0008002)1.88243423
77Volvulus (HP:0002580)1.87288230
78Renal cortical cysts (HP:0000803)1.87187813
79Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.83460238
80Round ear (HP:0100830)1.83218725
81Pancreatic cysts (HP:0001737)1.81658826
82Split foot (HP:0001839)1.81105067
83Type 2 muscle fiber atrophy (HP:0003554)1.81074381
84Hypophosphatemic rickets (HP:0004912)1.79530041
85Lethargy (HP:0001254)1.79435906
86Hypoplasia of the uterus (HP:0000013)1.75859801
87Increased serum pyruvate (HP:0003542)1.73091547
88Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.72037869
89Abnormality of alanine metabolism (HP:0010916)1.72037869
90Hyperalaninemia (HP:0003348)1.72037869
91Nephronophthisis (HP:0000090)1.71853719
92Neoplasm of the adrenal gland (HP:0100631)1.71526789
93Oligodactyly (HP:0012165)1.70647243
94Nemaline bodies (HP:0003798)1.70104235
95Upper limb muscle weakness (HP:0003484)1.69364074
96Limb hypertonia (HP:0002509)1.67413163
97Keratoconus (HP:0000563)1.67172673
98Increased corneal curvature (HP:0100692)1.67172673
99Death in childhood (HP:0003819)1.66888496
100Cheilitis (HP:0100825)1.64984474

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.30155648
2EIF2AK14.12641129
3TSSK63.35119263
4MST43.24132821
5TAF12.98439279
6NUAK12.67776496
7TXK2.50809853
8LMTK22.44385176
9EIF2AK32.43586755
10WNK42.39593539
11PHKG22.26133787
12PHKG12.26133787
13TAOK32.23310826
14BUB12.03454257
15TEC2.02887344
16NEK11.90394784
17PINK11.90370384
18VRK11.79801454
19PIM21.76124515
20ZAK1.69128690
21ARAF1.60817769
22NME11.54180290
23ADRBK21.46253985
24STK391.36709447
25GRK51.36320098
26OXSR11.35356948
27WNK11.35339709
28GRK11.34091997
29PLK31.29818813
30TIE11.21927457
31CSNK1G11.18084744
32SMG11.15458341
33SRPK11.15430077
34CSNK1G31.15163988
35EIF2AK21.14105180
36MAPKAPK31.11521562
37CSNK1A1L1.10066526
38PIK3CG1.09096322
39OBSCN1.08022225
40CSNK1G21.04790014
41PBK0.99562633
42DAPK10.96743922
43DYRK20.96171448
44MAP3K120.95713453
45TNK20.94067648
46CDC70.91167700
47MAP2K60.89443628
48TYRO30.87302000
49ITK0.86379314
50CAMK2G0.84401668
51TLK10.79282467
52MKNK20.78850660
53PASK0.76318417
54BCKDK0.74159640
55BCR0.71925337
56STK40.71468847
57BRAF0.70068079
58TRIM280.69766144
59PLK20.64225978
60DAPK30.62033484
61IKBKE0.60430119
62WNK30.58447663
63PRKCE0.58335641
64TGFBR10.55675889
65AKT30.54121174
66BMPR1B0.54075124
67PIM10.52630754
68FRK0.52549320
69MAPKAPK50.51632230
70PRKG20.49612980
71ATR0.49555417
72MELK0.48316134
73CHEK20.47583512
74PLK40.46927522
75ADRBK10.46047315
76MKNK10.45598787
77PRKCG0.43815546
78PDK20.43656475
79CAMKK20.43273719
80STK160.41768046
81IKBKB0.41565757
82PTK2B0.37355950
83PAK40.35688890
84RPS6KA50.34451479
85CSNK1A10.32163107
86WEE10.31455995
87SIK30.31252858
88TYK20.31208768
89GRK70.30821609
90KDR0.30580569
91PRKCI0.30487683
92MYLK0.30192176
93CSNK2A10.26159403
94NME20.25650123
95PAK10.25308191
96PRKG10.24674758
97CAMK2A0.24220720
98MAPK130.23796901
99CSNK1E0.23537129
100PRKCQ0.23369161

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.33796308
2Oxidative phosphorylation_Homo sapiens_hsa001903.67248295
3Parkinsons disease_Homo sapiens_hsa050123.38583447
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.93871319
5Ribosome_Homo sapiens_hsa030102.90730376
6Protein export_Homo sapiens_hsa030602.88371175
7RNA polymerase_Homo sapiens_hsa030202.54187766
8Alzheimers disease_Homo sapiens_hsa050102.36157225
9Huntingtons disease_Homo sapiens_hsa050162.17965176
10Asthma_Homo sapiens_hsa053102.16434045
11Homologous recombination_Homo sapiens_hsa034402.10933667
12RNA degradation_Homo sapiens_hsa030182.01362517
13Autoimmune thyroid disease_Homo sapiens_hsa053201.90268120
14Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.87994527
15Allograft rejection_Homo sapiens_hsa053301.83431599
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.68715835
17One carbon pool by folate_Homo sapiens_hsa006701.66582655
18Regulation of autophagy_Homo sapiens_hsa041401.63886104
19Cardiac muscle contraction_Homo sapiens_hsa042601.53815510
20Intestinal immune network for IgA production_Homo sapiens_hsa046721.49707376
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.42827126
22Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.39816261
23Sulfur metabolism_Homo sapiens_hsa009201.39434983
24Caffeine metabolism_Homo sapiens_hsa002321.36383481
25Basal transcription factors_Homo sapiens_hsa030221.34781998
26Antigen processing and presentation_Homo sapiens_hsa046121.33397678
27DNA replication_Homo sapiens_hsa030301.30311167
28Nucleotide excision repair_Homo sapiens_hsa034201.28859772
29Purine metabolism_Homo sapiens_hsa002301.27470199
30Graft-versus-host disease_Homo sapiens_hsa053321.27099079
31RNA transport_Homo sapiens_hsa030131.26933900
32Mismatch repair_Homo sapiens_hsa034301.24658730
33Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.20151980
34Propanoate metabolism_Homo sapiens_hsa006401.17162688
35Fanconi anemia pathway_Homo sapiens_hsa034601.15800541
36Spliceosome_Homo sapiens_hsa030401.15640828
37Linoleic acid metabolism_Homo sapiens_hsa005911.15522331
38Pyrimidine metabolism_Homo sapiens_hsa002401.13139889
39Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.08826018
40Primary immunodeficiency_Homo sapiens_hsa053401.06365138
41Phototransduction_Homo sapiens_hsa047441.04400338
42Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.01690721
43Non-homologous end-joining_Homo sapiens_hsa034500.98871561
44Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.98765020
45Nitrogen metabolism_Homo sapiens_hsa009100.93199624
46Systemic lupus erythematosus_Homo sapiens_hsa053220.89412263
47Arginine and proline metabolism_Homo sapiens_hsa003300.85840218
48Butanoate metabolism_Homo sapiens_hsa006500.83100814
49Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.82053707
50Folate biosynthesis_Homo sapiens_hsa007900.78645759
51Glutathione metabolism_Homo sapiens_hsa004800.78384738
52beta-Alanine metabolism_Homo sapiens_hsa004100.76445645
53Arachidonic acid metabolism_Homo sapiens_hsa005900.75382187
54Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.73856571
55alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.72007681
56Type I diabetes mellitus_Homo sapiens_hsa049400.68878445
57Hematopoietic cell lineage_Homo sapiens_hsa046400.68378569
58Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.64975905
59Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.63567442
60Nicotine addiction_Homo sapiens_hsa050330.63066808
61Chemical carcinogenesis_Homo sapiens_hsa052040.62086285
62Cysteine and methionine metabolism_Homo sapiens_hsa002700.61998056
63Ether lipid metabolism_Homo sapiens_hsa005650.60600209
64Peroxisome_Homo sapiens_hsa041460.59348110
65Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.59295538
66Metabolic pathways_Homo sapiens_hsa011000.58272219
67Circadian rhythm_Homo sapiens_hsa047100.55942477
68Tight junction_Homo sapiens_hsa045300.51652959
69Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.51551226
70Salivary secretion_Homo sapiens_hsa049700.50949157
71Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.49288557
72Retinol metabolism_Homo sapiens_hsa008300.49206366
73Tryptophan metabolism_Homo sapiens_hsa003800.49042906
74Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.44764793
75Rheumatoid arthritis_Homo sapiens_hsa053230.43272752
76Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.40673537
77Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.40161730
78Measles_Homo sapiens_hsa051620.37308048
79Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.36432175
80Cyanoamino acid metabolism_Homo sapiens_hsa004600.36186552
81Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.36166823
82Fat digestion and absorption_Homo sapiens_hsa049750.36090773
83Olfactory transduction_Homo sapiens_hsa047400.35821453
84Steroid hormone biosynthesis_Homo sapiens_hsa001400.35014437
85Morphine addiction_Homo sapiens_hsa050320.33772423
86Long-term depression_Homo sapiens_hsa047300.33494569
87Collecting duct acid secretion_Homo sapiens_hsa049660.33325957
88Steroid biosynthesis_Homo sapiens_hsa001000.32594148
89T cell receptor signaling pathway_Homo sapiens_hsa046600.32406801
90Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.29748651
91Pancreatic secretion_Homo sapiens_hsa049720.29733595
92Epstein-Barr virus infection_Homo sapiens_hsa051690.28439019
93ABC transporters_Homo sapiens_hsa020100.28107078
94Serotonergic synapse_Homo sapiens_hsa047260.27579135
95Tyrosine metabolism_Homo sapiens_hsa003500.27018644
96Base excision repair_Homo sapiens_hsa034100.25204266
97Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.24056671
98Mineral absorption_Homo sapiens_hsa049780.22839300
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.22356420
100NF-kappa B signaling pathway_Homo sapiens_hsa040640.22063235

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