ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of skeletal muscle contraction (GO:0014819)	7.38380952
2	skeletal muscle adaptation (GO:0043501)	6.10748830
3	striated muscle atrophy (GO:0014891)	5.78899299
4	negative regulation of muscle hypertrophy (GO:0014741)	5.64766966
5	muscle atrophy (GO:0014889)	5.33744087
6	negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)	5.00889158
7	skeletal muscle tissue regeneration (GO:0043403)	4.75406795
8	muscle filament sliding (GO:0030049)	4.74649641
9	actin-myosin filament sliding (GO:0033275)	4.74649641
10	regulation of centriole replication (GO:0046599)	4.64507619
11	protein deneddylation (GO:0000338)	4.42313743
12	ganglion development (GO:0061548)	4.38587554
13	response to muscle activity (GO:0014850)	4.36470206
14	positive regulation of mitochondrial calcium ion concentration (GO:0051561)	4.19256680
15	negative regulation of skeletal muscle tissue development (GO:0048642)	4.11991470
16	response to interferon-beta (GO:0035456)	4.11656099
17	cullin deneddylation (GO:0010388)	4.08663175
18	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla	4.03013575
19	platelet dense granule organization (GO:0060155)	3.95555082
20	protein K6-linked ubiquitination (GO:0085020)	3.88445201
21	DNA damage response, signal transduction resulting in transcription (GO:0042772)	3.85955064
22	proteasome assembly (GO:0043248)	3.81867048
23	actin-mediated cell contraction (GO:0070252)	3.76211437
24	heart field specification (GO:0003128)	3.75970121
25	secondary heart field specification (GO:0003139)	3.75970121
26	positive regulation of cardiac muscle cell differentiation (GO:2000727)	3.73870189
27	DNA deamination (GO:0045006)	3.71002284
28	mesenchymal cell differentiation involved in kidney development (GO:0072161)	3.57027773
29	mesenchymal cell differentiation involved in renal system development (GO:2001012)	3.57027773
30	extracellular fibril organization (GO:0043206)	3.56232837
31	protein polyglutamylation (GO:0018095)	3.52886311
32	protein maturation by protein folding (GO:0022417)	3.46063352
33	pseudouridine synthesis (GO:0001522)	3.45814382
34	detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)	3.44484707
35	cellular response to interferon-beta (GO:0035458)	3.41565865
36	response to testosterone (GO:0033574)	3.40535561
37	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	3.33125976
38	regulation of DNA endoreduplication (GO:0032875)	3.28485003
39	mesenchymal cell proliferation (GO:0010463)	3.27592920
40	cellular zinc ion homeostasis (GO:0006882)	3.22857817
41	kinetochore assembly (GO:0051382)	3.21663366
42	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.21637762
43	mesonephros development (GO:0001823)	3.19121331
44	positive regulation of actin filament depolymerization (GO:0030836)	3.18108553
45	morphogenesis of an endothelium (GO:0003159)	3.18100694
46	endothelial tube morphogenesis (GO:0061154)	3.18100694
47	maturation of 5.8S rRNA (GO:0000460)	3.15273254
48	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.14816486
49	regulation of gene expression by genetic imprinting (GO:0006349)	3.13164775
50	lung secretory cell differentiation (GO:0061140)	3.08217268
51	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	3.07773763
52	cartilage morphogenesis (GO:0060536)	3.07146612
53	retina homeostasis (GO:0001895)	3.01964288
54	growth hormone secretion (GO:0030252)	2.99915069
55	mitochondrial calcium ion homeostasis (GO:0051560)	2.97731090
56	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.93262561
57	regulation of cell proliferation involved in kidney development (GO:1901722)	2.91597227
58	mitotic nuclear envelope reassembly (GO:0007084)	2.91148054
59	nuclear envelope reassembly (GO:0031468)	2.91148054
60	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	2.90596055
61	lung morphogenesis (GO:0060425)	2.89811944
62	mitochondrion distribution (GO:0048311)	2.87432451
63	embryonic hindlimb morphogenesis (GO:0035116)	2.84958249
64	cellular response to dexamethasone stimulus (GO:0071549)	2.84330685
65	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.83573260
66	positive regulation of endothelial cell differentiation (GO:0045603)	2.83512789
67	mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)	2.82827171
68	cellular response to exogenous dsRNA (GO:0071360)	2.80787351
69	detection of chemical stimulus involved in sensory perception of taste (GO:0050912)	2.80526952
70	regulation of glomerulus development (GO:0090192)	2.78329461
71	negative regulation of striated muscle tissue development (GO:0045843)	2.76101052
72	response to activity (GO:0014823)	2.75469252
73	negative regulation of muscle tissue development (GO:1901862)	2.71844682
74	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.71632079
75	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.71632079
76	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.70625158
77	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.70625158
78	DNA damage response, signal transduction by p53 class mediator (GO:0030330)	2.68603277
79	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.68480905
80	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.68480905
81	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.68480905
82	striated muscle adaptation (GO:0014888)	2.68444841
83	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	2.67619140
84	regulation of relaxation of muscle (GO:1901077)	2.66700676
85	regulation of transcription involved in cell fate commitment (GO:0060850)	2.65976703
86	protein heterotetramerization (GO:0051290)	2.65244878
87	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.65223177
88	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.64998845
89	negative regulation of ligase activity (GO:0051352)	2.64998845
90	endoplasmic reticulum calcium ion homeostasis (GO:0032469)	2.62390023
91	regulation of timing of cell differentiation (GO:0048505)	2.62310990
92	xenobiotic catabolic process (GO:0042178)	2.61848243
93	positive regulation of inositol phosphate biosynthetic process (GO:0060732)	2.61228565
94	cranial suture morphogenesis (GO:0060363)	2.60517210
95	response to folic acid (GO:0051593)	2.58797407
96	interferon-gamma secretion (GO:0072643)	2.57802239
97	auditory behavior (GO:0031223)	2.56950750
98	protein complex biogenesis (GO:0070271)	2.55445394
99	response to dexamethasone (GO:0071548)	2.55260225
100	response to gravity (GO:0009629)	10.0780407

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	6.15677401
2	VDR_22108803_ChIP-Seq_LS180_Human	5.00167167
3	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	3.90871790
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.67942621
5	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.57015997
6	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	3.39738213
7	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.17194705
8	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.15755994
9	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.05346327
10	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.03558701
11	HIF1A_21447827_ChIP-Seq_MCF-7_Human	2.85459798
12	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.62211852
13	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.53500823
14	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.31822449
15	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.30550894
16	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	2.23937477
17	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.18711223
18	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.17109378
19	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.14729969
20	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.13613219
21	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.02033310
22	RARG_19884340_ChIP-ChIP_MEFs_Mouse	2.01723567
23	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.00066663
24	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.99122334
25	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.97104312
26	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.96685078
27	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.96203319
28	ELK1_19687146_ChIP-ChIP_HELA_Human	1.93357233
29	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.91526953
30	ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	1.90742517
31	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.81234770
32	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.71632180
33	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.68202522
34	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.66876778
35	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.65068277
36	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.64925897
37	GABP_19822575_ChIP-Seq_HepG2_Human	1.64737821
38	VDR_23849224_ChIP-Seq_CD4+_Human	1.62272371
39	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.59023342
40	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.56284835
41	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.55423517
42	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.54634390
43	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.52676223
44	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.45825331
45	CIITA_25753668_ChIP-Seq_RAJI_Human	1.45724912
46	JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.45562774
47	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.44870128
48	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.43582794
49	TAF15_26573619_Chip-Seq_HEK293_Human	1.41781256
50	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.41766785
51	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.41349464
52	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.41243159
53	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.36103703
54	CBP_21632823_ChIP-Seq_H3396_Human	1.35768029
55	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.35575944
56	MYC_18940864_ChIP-ChIP_HL60_Human	1.34412497
57	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.32879107
58	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.31788534
59	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.28882260
60	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.25431039
61	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.22657861
62	FUS_26573619_Chip-Seq_HEK293_Human	1.21270213
63	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.19613538
64	CJUN_26792858_Chip-Seq_BT549_Human	1.19189821
65	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.17665002
66	FOXP3_21729870_ChIP-Seq_TREG_Human	1.16935305
67	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	1.14782834
68	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.10612258
69	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.08366045
70	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.07111071
71	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.06786937
72	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.03623528
73	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	1.03400335
74	SMAD2_18955504_ChIP-ChIP_HaCaT_Human	1.03400335
75	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.01967050
76	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.97680312
77	XRN2_22483619_ChIP-Seq_HELA_Human	0.97330484
78	STAT4_19710469_ChIP-ChIP_TH1__Mouse	0.96978393
79	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.95213432
80	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.91894741
81	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	0.91824478
82	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	0.91335500
83	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.90831228
84	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.90567287
85	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.90506623
86	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.90153704
87	CTCF_18555785_ChIP-Seq_MESCs_Mouse	0.88869032
88	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	0.87303090
89	ELF5_23300383_ChIP-Seq_T47D_Human	0.86878055
90	SOX17_20123909_ChIP-Seq_XEN_Mouse	0.83887939
91	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	0.83750316
92	EOMES_21245162_ChIP-Seq_HESCs_Human	0.83026464
93	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	0.81887987
94	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	0.81799539
95	CSB_26484114_Chip-Seq_FIBROBLAST_Human	0.80512318
96	POU5F1_16518401_ChIP-PET_MESCs_Mouse	0.80028368
97	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.79106383
98	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.78617170
99	DCP1A_22483619_ChIP-Seq_HELA_Human	0.78343251
100	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.77112053

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003950_abnormal_plasma_membrane	4.54126268
2	MP0000751_myopathy	4.27290755
3	MP0000747_muscle_weakness	3.93831386
4	MP0000749_muscle_degeneration	3.04229152
5	MP0003646_muscle_fatigue	2.89999111
6	MP0002089_abnormal_postnatal_growth/wei	2.65508190
7	MP0000750_abnormal_muscle_regeneration	2.53048008
8	MP0002822_catalepsy	2.51515851
9	MP0003123_paternal_imprinting	2.45079677
10	MP0004145_abnormal_muscle_electrophysio	2.41970543
11	MP0002269_muscular_atrophy	2.41839507
12	MP0005257_abnormal_intraocular_pressure	2.41679163
13	MP0002095_abnormal_skin_pigmentation	2.29366241
14	MP0000759_abnormal_skeletal_muscle	2.29153077
15	MP0000372_irregular_coat_pigmentation	2.22453658
16	MP0004036_abnormal_muscle_relaxation	2.15042716
17	MP0008789_abnormal_olfactory_epithelium	2.08879467
18	MP0000427_abnormal_hair_cycle	1.99675757
19	MP0008775_abnormal_heart_ventricle	1.97287208
20	MP0002106_abnormal_muscle_physiology	1.93787738
21	MP0001968_abnormal_touch/_nociception	1.71279203
22	MP0004147_increased_porphyrin_level	1.69859388
23	MP0010030_abnormal_orbit_morphology	1.69404809
24	MP0000733_abnormal_muscle_development	1.54361536
25	MP0009780_abnormal_chondrocyte_physiolo	1.53922892
26	MP0000569_abnormal_digit_pigmentation	1.46779440
27	MP0004885_abnormal_endolymph	1.46710392
28	MP0005620_abnormal_muscle_contractility	1.46709857
29	MP0006072_abnormal_retinal_apoptosis	1.46368252
30	MP0005083_abnormal_biliary_tract	1.45335835
31	MP0005369_muscle_phenotype	1.43586634
32	MP0002177_abnormal_outer_ear	1.42814305
33	MP0003937_abnormal_limbs/digits/tail_de	1.41250322
34	MP0010368_abnormal_lymphatic_system	1.36041340
35	MP0002295_abnormal_pulmonary_circulatio	1.35404494
36	MP0001879_abnormal_lymphatic_vessel	1.34871113
37	MP0003191_abnormal_cellular_cholesterol	1.30872051
38	MP0002332_abnormal_exercise_endurance	1.30743561
39	MP0004087_abnormal_muscle_fiber	1.30122038
40	MP0002653_abnormal_ependyma_morphology	1.29693716
41	MP0002736_abnormal_nociception_after	1.28105283
42	MP0009745_abnormal_behavioral_response	1.26171099
43	MP0000383_abnormal_hair_follicle	1.26090811
44	MP0003942_abnormal_urinary_system	1.25451928
45	MP0004134_abnormal_chest_morphology	1.21855744
46	MP0010678_abnormal_skin_adnexa	1.21577785
47	MP0001299_abnormal_eye_distance/	1.19663845
48	MP0000013_abnormal_adipose_tissue	1.18139156
49	MP0000049_abnormal_middle_ear	1.14870549
50	MP0000647_abnormal_sebaceous_gland	1.14292185
51	MP0003718_maternal_effect	1.14089073
52	MP0004142_abnormal_muscle_tone	1.13813369
53	MP0003111_abnormal_nucleus_morphology	1.12642524
54	MP0001542_abnormal_bone_strength	1.09477418
55	MP0001529_abnormal_vocalization	1.06431073
56	MP0001905_abnormal_dopamine_level	1.03606602
57	MP0002108_abnormal_muscle_morphology	1.02304153
58	MP0003786_premature_aging	1.01862636
59	MP0004133_heterotaxia	1.01414133
60	MP0001243_abnormal_dermal_layer	0.99080484
61	MP0010234_abnormal_vibrissa_follicle	0.98239686
62	MP0005171_absent_coat_pigmentation	0.96074213
63	MP0000613_abnormal_salivary_gland	0.95110431
64	MP0000534_abnormal_ureter_morphology	0.94895807
65	MP0003077_abnormal_cell_cycle	0.92904289
66	MP0003656_abnormal_erythrocyte_physiolo	0.86007588
67	MP0004270_analgesia	0.85880654
68	MP0005165_increased_susceptibility_to	0.85710465
69	MP0002282_abnormal_trachea_morphology	0.84289725
70	MP0000762_abnormal_tongue_morphology	0.84001042
71	MP0005197_abnormal_uvea_morphology	0.82514065
72	MP0002075_abnormal_coat/hair_pigmentati	0.82266104
73	MP0002735_abnormal_chemical_nociception	0.80971831
74	MP0002733_abnormal_thermal_nociception	0.79588375
75	MP0002896_abnormal_bone_mineralization	0.79348395
76	MP0009250_abnormal_appendicular_skeleto	0.77651661
77	MP0010094_abnormal_chromosome_stability	0.75492658
78	MP0002233_abnormal_nose_morphology	0.74939914
79	MP0003705_abnormal_hypodermis_morpholog	0.74806648
80	MP0005646_abnormal_pituitary_gland	0.74149898
81	MP0008770_decreased_survivor_rate	0.72553577
82	MP0002734_abnormal_mechanical_nocicepti	0.70896789
83	MP0003385_abnormal_body_wall	0.70421006
84	MP0000537_abnormal_urethra_morphology	0.70029610
85	MP0003959_abnormal_lean_body	0.69475171
86	MP0002138_abnormal_hepatobiliary_system	0.68508467
87	MP0003943_abnormal_hepatobiliary_system	0.66623882
88	MP0004484_altered_response_of	0.65367427
89	MP0005499_abnormal_olfactory_system	0.64178129
90	MP0005394_taste/olfaction_phenotype	0.64178129
91	MP0003119_abnormal_digestive_system	0.62003170
92	MP0003755_abnormal_palate_morphology	0.61966110
93	MP0002938_white_spotting	0.61936992
94	MP0005174_abnormal_tail_pigmentation	0.61852863
95	MP0001340_abnormal_eyelid_morphology	0.61268883
96	MP0006054_spinal_hemorrhage	0.59546932
97	MP0002184_abnormal_innervation	0.59416054
98	MP0003806_abnormal_nucleotide_metabolis	0.59200014
99	MP0002751_abnormal_autonomic_nervous	0.57608850
100	MP0005253_abnormal_eye_physiology	0.55343722

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Palpebral edema (HP:0100540)	5.54354576
2	Fibular aplasia (HP:0002990)	5.03010045
3	Mask-like facies (HP:0000298)	4.98539180
4	Aplasia involving bones of the extremities (HP:0009825)	4.19531910
5	Aplasia involving bones of the upper limbs (HP:0009823)	4.19531910
6	Aplasia of the phalanges of the hand (HP:0009802)	4.19531910
7	Ulnar deviation of the wrist (HP:0003049)	3.75207045
8	Conjunctival hamartoma (HP:0100780)	3.68101317
9	Absent phalangeal crease (HP:0006109)	3.62100199
10	Nemaline bodies (HP:0003798)	3.54808011
11	Short tibia (HP:0005736)	3.52926914
12	Reduced subcutaneous adipose tissue (HP:0003758)	3.38052053
13	Adrenal hypoplasia (HP:0000835)	3.23782012
14	Aplasia/Hypoplasia of the tibia (HP:0005772)	3.16544531
15	Microglossia (HP:0000171)	3.10086807
16	Exercise-induced myalgia (HP:0003738)	3.08045250
17	Glucose intolerance (HP:0000833)	2.97393905
18	Severe muscular hypotonia (HP:0006829)	2.96134666
19	Round ear (HP:0100830)	2.93573315
20	Abnormal finger flexion creases (HP:0006143)	2.91133089
21	Distal arthrogryposis (HP:0005684)	2.88366871
22	Delayed CNS myelination (HP:0002188)	2.87345974
23	Deformed tarsal bones (HP:0008119)	2.79625941
24	Abnormal gallbladder physiology (HP:0012438)	2.78491091
25	Cholecystitis (HP:0001082)	2.78491091
26	Muscle fiber inclusion bodies (HP:0100299)	2.75982792
27	Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)	2.75968870
28	Calcaneovalgus deformity (HP:0001848)	2.75069972
29	Elevated erythrocyte sedimentation rate (HP:0003565)	2.75054966
30	Absent speech (HP:0001344)	2.74000698
31	Hyperkalemia (HP:0002153)	2.68630848
32	Hepatocellular necrosis (HP:0001404)	2.66816713
33	Secondary amenorrhea (HP:0000869)	2.53735186
34	IgG deficiency (HP:0004315)	2.44605131
35	Mesomelia (HP:0003027)	2.44231097
36	Abnormality of the pons (HP:0007361)	2.37403869
37	Paralysis (HP:0003470)	2.37074460
38	IgM deficiency (HP:0002850)	2.32930341
39	Entropion (HP:0000621)	2.32614488
40	Hepatic necrosis (HP:0002605)	2.27804681
41	Myopathic facies (HP:0002058)	2.24968134
42	Progressive microcephaly (HP:0000253)	2.21849642
43	3-Methylglutaconic aciduria (HP:0003535)	2.21033001
44	Neck muscle weakness (HP:0000467)	2.20237681
45	Type 2 muscle fiber atrophy (HP:0003554)	2.17988118
46	Hamartoma of the eye (HP:0010568)	2.17671239
47	Down-sloping shoulders (HP:0200021)	2.16597052
48	Submucous cleft hard palate (HP:0000176)	2.13008015
49	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.12054125
50	Absent hand (HP:0004050)	2.10961858
51	Periorbital edema (HP:0100539)	2.10749774
52	Short 4th metacarpal (HP:0010044)	2.10455319
53	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	2.10455319
54	Facial edema (HP:0000282)	2.07771788
55	Cavernous hemangioma (HP:0001048)	2.06896370
56	Amyloidosis (HP:0011034)	2.06699886
57	Action tremor (HP:0002345)	2.06587417
58	Abnormality of the columella (HP:0009929)	2.06371063
59	Aplasia/Hypoplasia of the fibula (HP:0006492)	2.03147601
60	2-3 toe syndactyly (HP:0004691)	2.02718666
61	Lower limb amyotrophy (HP:0007210)	2.00803173
62	Mitochondrial inheritance (HP:0001427)	1.98520799
63	Muscle fiber atrophy (HP:0100295)	1.95054197
64	Decreased circulating renin level (HP:0003351)	1.94636186
65	Increased CSF lactate (HP:0002490)	1.93224345
66	Cerebral hypomyelination (HP:0006808)	1.92876494
67	Hypokinesia (HP:0002375)	1.91726634
68	Emotional lability (HP:0000712)	1.90190452
69	Acute necrotizing encephalopathy (HP:0006965)	1.89335523
70	Opisthotonus (HP:0002179)	1.88744167
71	Abnormal glucose tolerance (HP:0001952)	1.85875161
72	Hypoplasia of the uterus (HP:0000013)	1.85484129
73	Toxemia of pregnancy (HP:0100603)	1.85349624
74	Furrowed tongue (HP:0000221)	1.82668042
75	Aplasia/Hypoplasia of the ulna (HP:0006495)	1.78734757
76	Hypoplastic pelvis (HP:0008839)	1.77746261
77	Increased serum lactate (HP:0002151)	1.77107661
78	True hermaphroditism (HP:0010459)	1.74695306
79	Neonatal respiratory distress (HP:0002643)	1.73441517
80	Abnormal mitochondria in muscle tissue (HP:0008316)	1.73368797
81	Decreased subcutaneous fat (HP:0001002)	1.72584232
82	Bone cyst (HP:0012062)	1.72042410
83	Short femoral neck (HP:0100864)	1.71954372
84	Myoglobinuria (HP:0002913)	1.70981720
85	Increased connective tissue (HP:0009025)	1.70318958
86	Myotonia (HP:0002486)	1.70019841
87	Intellectual disability, moderate (HP:0002342)	1.69742996
88	Preaxial hand polydactyly (HP:0001177)	1.69677933
89	Asplenia (HP:0001746)	1.67483264
90	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.67191563
91	Absent septum pellucidum (HP:0001331)	1.66717578
92	Type 1 muscle fiber predominance (HP:0003803)	1.66613284
93	Fatigue (HP:0012378)	1.65548918
94	Neuroendocrine neoplasm (HP:0100634)	1.65203521
95	Type I transferrin isoform profile (HP:0003642)	1.62770475
96	Palpitations (HP:0001962)	1.62682186
97	Abnormal protein glycosylation (HP:0012346)	1.61829957
98	Abnormal glycosylation (HP:0012345)	1.61829957
99	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.61829957
100	Abnormal protein N-linked glycosylation (HP:0012347)	1.61829957

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	VRK2	5.26229495
2	NME2	5.17923059
3	TESK2	4.15555301
4	MAP4K2	3.96801589
5	TESK1	3.80067436
6	PHKG2	3.64613827
7	PHKG1	3.64613827
8	NUAK1	3.33388226
9	LIMK1	3.25431836
10	ARAF	3.00190325
11	LMTK2	2.80621847
12	CASK	2.45223688
13	MOS	2.18480210
14	EIF2AK1	1.79921121
15	TAF1	1.68890538
16	BUB1	1.50035697
17	CCNB1	1.49229522
18	PIM2	1.47843942
19	EPHA2	1.38076816
20	CSNK1A1L	1.33398209
21	CSNK1G3	1.30121984
22	ABL2	1.27879893
23	OBSCN	1.24153434
24	BCKDK	1.21204133
25	CSNK1G1	1.19464388
26	CSNK1G2	1.17282567
27	RAF1	1.14973484
28	NEK1	1.13087048
29	LATS1	1.10734625
30	TIE1	1.10311360
31	TLK1	1.09668080
32	VRK1	1.09415838
33	TXK	1.07041486
34	DAPK1	0.95607991
35	WNK4	0.89160211
36	MAP3K9	0.87955346
37	NEK9	0.87060780
38	SRPK1	0.82193036
39	EIF2AK3	0.81405193
40	PBK	0.81256495
41	MAPKAPK3	0.81164430
42	SMG1	0.80597851
43	BRAF	0.79793170
44	AURKA	0.78771260
45	PTK2B	0.76594015
46	EIF2AK2	0.74999134
47	MAP2K7	0.74071434
48	STK16	0.73213758
49	PRKD3	0.70088554
50	GRK5	0.61685768
51	MAP3K12	0.61103743
52	MARK3	0.59216331
53	TSSK6	0.56079744
54	ILK	0.50983957
55	CHEK2	0.50109821
56	TNIK	0.47977754
57	STK38L	0.47204092
58	HIPK2	0.44677540
59	MAPK13	0.44134190
60	STK38	0.40228354
61	AKT3	0.39369459
62	DYRK2	0.39226647
63	MAPK7	0.38850469
64	TRIM28	0.36898293
65	MAPK11	0.35888022
66	TAOK1	0.35644319
67	KSR1	0.35172217
68	PAK6	0.34629068
69	PRKD2	0.33891683
70	MAP3K13	0.31893531
71	MST4	0.30793100
72	PAK1	0.30720351
73	PIM1	0.29958390
74	MET	0.29884194
75	JAK3	0.29450001
76	PLK3	0.28815236
77	ERBB2	0.27535191
78	CAMK2G	0.25637197
79	MARK1	0.25377989
80	MINK1	0.25364497
81	EPHA4	0.25157923
82	EPHB2	0.25016758
83	CSNK1A1	0.24578718
84	ERBB4	0.23627777
85	WNK1	0.23490404
86	ATR	0.22518308
87	NTRK2	0.21440509
88	MKNK2	0.21106056
89	PRKCI	0.21030860
90	PIK3CA	0.19470933
91	INSRR	0.19433482
92	PDK2	0.18483258
93	PRKCE	0.16280422
94	KDR	0.14869186
95	DYRK1A	0.14172607
96	CDK7	0.13919166
97	PRKG1	0.13444886
98	STK10	0.12565935
99	TAOK2	0.12372604
100	CSNK2A1	0.12311202

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	5.19096219
2	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.98157054
3	Circadian rhythm_Homo sapiens_hsa04710	2.60926743
4	Hedgehog signaling pathway_Homo sapiens_hsa04340	2.52934607
5	RNA polymerase_Homo sapiens_hsa03020	2.47057984
6	Sulfur relay system_Homo sapiens_hsa04122	2.46199571
7	Salivary secretion_Homo sapiens_hsa04970	2.36003918
8	Folate biosynthesis_Homo sapiens_hsa00790	2.32017446
9	Regulation of autophagy_Homo sapiens_hsa04140	2.28169260
10	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.10185571
11	Tight junction_Homo sapiens_hsa04530	2.01433391
12	Oxidative phosphorylation_Homo sapiens_hsa00190	1.97093639
13	Basal cell carcinoma_Homo sapiens_hsa05217	1.93303102
14	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.91875290
15	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.75101060
16	Huntingtons disease_Homo sapiens_hsa05016	1.68331038
17	Parkinsons disease_Homo sapiens_hsa05012	1.59942333
18	Wnt signaling pathway_Homo sapiens_hsa04310	1.55829162
19	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.52867445
20	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.52793386
21	Ribosome_Homo sapiens_hsa03010	1.52215689
22	Nitrogen metabolism_Homo sapiens_hsa00910	1.49355112
23	Alzheimers disease_Homo sapiens_hsa05010	1.46961981
24	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.37525728
25	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.32912852
26	Pyrimidine metabolism_Homo sapiens_hsa00240	1.31987684
27	Nucleotide excision repair_Homo sapiens_hsa03420	1.31475107
28	Spliceosome_Homo sapiens_hsa03040	1.29616159
29	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.23384869
30	Purine metabolism_Homo sapiens_hsa00230	1.22148353
31	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.22037186
32	Glutathione metabolism_Homo sapiens_hsa00480	1.15845116
33	Base excision repair_Homo sapiens_hsa03410	1.15438169
34	RNA degradation_Homo sapiens_hsa03018	1.15019639
35	RNA transport_Homo sapiens_hsa03013	1.11259534
36	Basal transcription factors_Homo sapiens_hsa03022	1.09832325
37	Cardiac muscle contraction_Homo sapiens_hsa04260	1.07145936
38	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.05775624
39	Shigellosis_Homo sapiens_hsa05131	1.05749107
40	Homologous recombination_Homo sapiens_hsa03440	1.05506809
41	Carbon metabolism_Homo sapiens_hsa01200	1.03257831
42	Oocyte meiosis_Homo sapiens_hsa04114	1.03187416
43	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.99418200
44	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.98032559
45	Fanconi anemia pathway_Homo sapiens_hsa03460	0.96943150
46	Pentose phosphate pathway_Homo sapiens_hsa00030	0.92084264
47	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.91643110
48	Morphine addiction_Homo sapiens_hsa05032	0.90043039
49	Mineral absorption_Homo sapiens_hsa04978	0.89664503
50	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.88267549
51	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.88064588
52	Glucagon signaling pathway_Homo sapiens_hsa04922	0.83912070
53	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.81783616
54	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.80890027
55	Hippo signaling pathway_Homo sapiens_hsa04390	0.80431750
56	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.80057839
57	Thyroid cancer_Homo sapiens_hsa05216	0.79503770
58	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.79021642
59	DNA replication_Homo sapiens_hsa03030	0.78019747
60	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.77694919
61	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.73342491
62	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.71929820
63	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.71918382
64	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.71900976
65	Primary immunodeficiency_Homo sapiens_hsa05340	0.71836717
66	Vibrio cholerae infection_Homo sapiens_hsa05110	0.70599701
67	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.68427109
68	Phototransduction_Homo sapiens_hsa04744	0.68360131
69	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.66636755
70	Gastric acid secretion_Homo sapiens_hsa04971	0.63690452
71	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.59595223
72	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.59440974
73	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.59328008
74	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.58518040
75	Nicotine addiction_Homo sapiens_hsa05033	0.58367528
76	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.56758353
77	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.56430702
78	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.55743866
79	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.55544087
80	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.54536389
81	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.54070967
82	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.54015350
83	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.52362770
84	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.48730702
85	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.46407413
86	Calcium signaling pathway_Homo sapiens_hsa04020	0.44586187
87	Mismatch repair_Homo sapiens_hsa03430	0.43515431
88	Peroxisome_Homo sapiens_hsa04146	0.42736498
89	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.37305407
90	Adherens junction_Homo sapiens_hsa04520	0.37019964
91	Fatty acid elongation_Homo sapiens_hsa00062	0.37010663
92	Metabolic pathways_Homo sapiens_hsa01100	0.35476928
93	Caffeine metabolism_Homo sapiens_hsa00232	0.35031383
94	GABAergic synapse_Homo sapiens_hsa04727	0.31675283
95	Circadian entrainment_Homo sapiens_hsa04713	0.31310940
96	Chemical carcinogenesis_Homo sapiens_hsa05204	0.31119258
97	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.29773425
98	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.28961883
99	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.27951182
100	Arginine biosynthesis_Homo sapiens_hsa00220	0.26929497

GAPDHP51

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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