ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of sister chromatid cohesion (GO:0007063)	9.75044415
2	negative regulation of peptidyl-threonine phosphorylation (GO:0010801)	9.67802394
3	eosinophil migration (GO:0072677)	9.55229296
4	regulation of mononuclear cell migration (GO:0071675)	9.43073156
5	branch elongation of an epithelium (GO:0060602)	8.46679435
6	positive regulation of chromosome segregation (GO:0051984)	8.07990276
7	negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)	8.03334684
8	fucose catabolic process (GO:0019317)	7.85031963
9	L-fucose metabolic process (GO:0042354)	7.85031963
10	L-fucose catabolic process (GO:0042355)	7.85031963
11	negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)	7.78683409
12	peptidyl-lysine dimethylation (GO:0018027)	7.70689729
13	vesicle fusion (GO:0006906)	7.64778613
14	ribosomal small subunit assembly (GO:0000028)	7.41647264
15	coenzyme A biosynthetic process (GO:0015937)	7.23025704
16	autophagic vacuole fusion (GO:0000046)	6.88402839
17	macrophage chemotaxis (GO:0048246)	6.66710589
18	organ growth (GO:0035265)	6.62782584
19	localization within membrane (GO:0051668)	6.59447582
20	axis elongation (GO:0003401)	6.39465604
21	regulation of beta-amyloid formation (GO:1902003)	6.05538258
22	establishment of mitotic spindle orientation (GO:0000132)	5.98087220
23	regulation of nitric-oxide synthase biosynthetic process (GO:0051769)	5.95846241
24	positive regulation of calcium ion import (GO:0090280)	5.89112006
25	negative regulation of GTPase activity (GO:0034260)	5.87834265
26	negative regulation of GTP catabolic process (GO:0033125)	5.87834265
27	regulation of T cell receptor signaling pathway (GO:0050856)	5.68292087
28	monocyte chemotaxis (GO:0002548)	5.53936453
29	protein import into peroxisome matrix (GO:0016558)	5.46636848
30	organelle membrane fusion (GO:0090174)	5.42477883
31	double-strand break repair via nonhomologous end joining (GO:0006303)	5.38251403
32	non-recombinational repair (GO:0000726)	5.38251403
33	3-UTR-mediated mRNA stabilization (GO:0070935)	5.33141599
34	establishment of mitotic spindle localization (GO:0040001)	5.29751914
35	establishment of spindle orientation (GO:0051294)	5.21926379
36	seminiferous tubule development (GO:0072520)	5.15038019
37	acrosome assembly (GO:0001675)	5.11150018
38	negative regulation of circadian rhythm (GO:0042754)	4.96605368
39	histone H3-K9 methylation (GO:0051567)	4.90487135
40	regulation of amyloid precursor protein catabolic process (GO:1902991)	4.85411198
41	positive chemotaxis (GO:0050918)	4.68674801
42	oxidative demethylation (GO:0070989)	4.68533752
43	detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)	4.63425826
44	organelle fusion (GO:0048284)	4.62772660
45	pantothenate metabolic process (GO:0015939)	4.60918733
46	positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)	4.57849606
47	regulation of stem cell maintenance (GO:2000036)	4.57497071
48	purine nucleoside bisphosphate biosynthetic process (GO:0034033)	4.54787566
49	ribonucleoside bisphosphate biosynthetic process (GO:0034030)	4.54787566
50	nucleoside bisphosphate biosynthetic process (GO:0033866)	4.54787566
51	fucose metabolic process (GO:0006004)	4.49070256
52	regulation of autophagic vacuole assembly (GO:2000785)	4.32706411
53	protein targeting to lysosome (GO:0006622)	4.29616584
54	establishment of protein localization to vacuole (GO:0072666)	4.29616584
55	protein targeting to vacuole (GO:0006623)	4.29616584
56	coenzyme A metabolic process (GO:0015936)	4.18919214
57	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	4.17165145
58	fucosylation (GO:0036065)	4.16301631
59	histone H3-K9 modification (GO:0061647)	4.11286835
60	negative regulation of purine nucleotide catabolic process (GO:0033122)	4.07648301
61	detection of chemical stimulus involved in sensory perception of taste (GO:0050912)	4.05166802
62	regulation of fibroblast growth factor receptor signaling pathway (GO:0040036)	4.03606705
63	regulation of antigen receptor-mediated signaling pathway (GO:0050854)	4.03298499
64	regulation of cellular amide metabolic process (GO:0034248)	3.96124271
65	single-organism membrane fusion (GO:0044801)	3.91313033
66	negative regulation of nucleotide catabolic process (GO:0030812)	3.91277484
67	regulation of mammary gland epithelial cell proliferation (GO:0033599)	3.90247635
68	membrane budding (GO:0006900)	3.89016466
69	establishment of spindle localization (GO:0051293)	3.84421494
70	negative regulation of nucleoside metabolic process (GO:0045978)	3.72299135
71	regulation of peptidyl-threonine phosphorylation (GO:0010799)	3.70028665
72	vesicle targeting (GO:0006903)	3.65292786
73	Golgi transport vesicle coating (GO:0048200)	3.61959881
74	COPI coating of Golgi vesicle (GO:0048205)	3.61959881
75	regulation of vacuole organization (GO:0044088)	3.60485621
76	establishment of protein localization to peroxisome (GO:0072663)	3.55656297
77	protein localization to peroxisome (GO:0072662)	3.55656297
78	protein targeting to peroxisome (GO:0006625)	3.55656297
79	DNA integration (GO:0015074)	3.54124328
80	regulation of calcium ion import (GO:0090279)	3.53289055
81	ER to Golgi vesicle-mediated transport (GO:0006888)	3.49805157
82	imidazole-containing compound metabolic process (GO:0052803)	3.48307468
83	regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:2	3.48247546
84	negative regulation of dendrite morphogenesis (GO:0050774)	3.47669530
85	sodium-independent organic anion transport (GO:0043252)	3.45483966
86	negative regulation of macroautophagy (GO:0016242)	3.40591366
87	RNA methylation (GO:0001510)	3.35999498
88	peroxisomal transport (GO:0043574)	3.32158460
89	telomere maintenance via recombination (GO:0000722)	3.30704092
90	COPII vesicle coating (GO:0048208)	3.28372216
91	labyrinthine layer development (GO:0060711)	3.28044922
92	peptidyl-lysine trimethylation (GO:0018023)	3.27176645
93	prenylation (GO:0097354)	12.7531037
94	protein prenylation (GO:0018342)	12.7531037
95	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	12.4085003
96	positive regulation of mitotic sister chromatid separation (GO:1901970)	12.4085003
97	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	12.4085003
98	negative regulation of Ras GTPase activity (GO:0034261)	12.3112470
99	eosinophil chemotaxis (GO:0048245)	10.5568744
100	negative regulation of T cell receptor signaling pathway (GO:0050860)	10.3125489

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	9.11007984
2	VDR_22108803_ChIP-Seq_LS180_Human	6.36146672
3	NOTCH1_21737748_ChIP-Seq_TLL_Human	4.59826226
4	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	4.45029670
5	AR_21572438_ChIP-Seq_LNCaP_Human	3.48948812
6	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.97681235
7	SRY_22984422_ChIP-ChIP_TESTIS_Rat	2.73346913
8	ZIC3_20872845_ChIP-ChIP_MESCs_Mouse	2.64233916
9	ZNF263_19887448_ChIP-Seq_K562_Human	2.60522780
10	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.36710910
11	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.36212528
12	YY1_21170310_ChIP-Seq_MESCs_Mouse	2.35850102
13	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	2.35329766
14	GATA1_22025678_ChIP-Seq_K562_Human	11.7532144
15	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.93446862
16	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.93446862
17	RXR_22108803_ChIP-Seq_LS180_Human	1.84220928
18	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.75041897
19	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.65000178
20	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.60255086
21	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.60255086
22	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.60255086
23	BCAT_22108803_ChIP-Seq_LS180_Human	1.57513814
24	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.57315683
25	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.50836767
26	TAF15_26573619_Chip-Seq_HEK293_Human	1.42899875
27	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.40699647
28	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.38478345
29	TP53_16413492_ChIP-PET_HCT116_Human	1.36583542
30	GATA3_26560356_Chip-Seq_TH1_Human	1.34613952
31	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.29547314
32	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.24015983
33	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.22329884
34	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.21303804
35	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.18971676
36	IRF1_19129219_ChIP-ChIP_H3396_Human	1.18946344
37	GBX2_23144817_ChIP-Seq_PC3_Human	1.18130033
38	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.10487248
39	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.08984630
40	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.07294954
41	RUNX_20019798_ChIP-Seq_JUKART_Human	1.04463588
42	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.03868892
43	CTCF_21964334_Chip-Seq_Bcells_Human	1.00313368
44	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	0.96955595
45	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.96899713
46	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	0.95037609
47	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	0.89184299
48	GATA1_19941826_ChIP-Seq_K562_Human	0.88825928
49	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.88351412
50	TBX3_20139965_ChIP-Seq_ESCs_Mouse	0.86961295
51	TBX3_20139965_ChIP-Seq_MESCs_Mouse	0.86790748
52	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.86755866
53	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	0.86458171
54	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.85996990
55	CTNNB1_20460455_ChIP-Seq_HCT116_Human	0.82183888
56	NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human	0.81602292
57	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.79643567
58	CDX2_20551321_ChIP-Seq_CACO-2_Human	0.79342776
59	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.78921845
60	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	0.78427700
61	EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	0.76664227
62	SOX3_22085726_ChIP-Seq_MUSCLE_Mouse	0.76271757
63	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	0.75273212
64	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.72146752
65	ZNF274_21170338_ChIP-Seq_K562_Hela	0.71686173
66	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.66610205
67	TP53_22573176_ChIP-Seq_HFKS_Human	0.66481026
68	RING1B_27294783_Chip-Seq_NPCs_Mouse	0.66251471
69	TRIM28_19339689_ChIP-ChIP_MESCs_Mouse	0.63292492
70	FUS_26573619_Chip-Seq_HEK293_Human	0.62538176
71	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	0.62471708
72	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.62018532
73	ETS1_20019798_ChIP-Seq_JURKAT_Human	0.61059295
74	STAT1_20625510_ChIP-Seq_HELA_Human	0.59637110
75	SMC1_22415368_ChIP-Seq_MEFs_Mouse	0.59403065
76	GATA3_21867929_ChIP-Seq_TH1_Mouse	0.59305698
77	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.58684663
78	EOMES_20176728_ChIP-ChIP_TSCs_Mouse	0.57524721
79	OCT1_27270436_Chip-Seq_PROSTATE_Human	0.57504110
80	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.57317711
81	TCF4_22108803_ChIP-Seq_LS180_Human	0.57282723
82	LUZP1_20508642_ChIP-Seq_ESCs_Mouse	0.57258590
83	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.56982294
84	HTT_18923047_ChIP-ChIP_STHdh_Human	0.56962732
85	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.56741828
86	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.56114754
87	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.54612105
88	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.53399188
89	GATA2_19941826_ChIP-Seq_K562_Human	0.52774356
90	NR3C1_23031785_ChIP-Seq_PC12_Mouse	0.52662400
91	SMC3_22415368_ChIP-Seq_MEFs_Mouse	0.52250761
92	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.51952336
93	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.51628102
94	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	0.51503537
95	SOX9_24532713_ChIP-Seq_HFSC_Mouse	0.51235424
96	NANOG_20526341_ChIP-Seq_ESCs_Human	0.50851979
97	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.50809646
98	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.50796988
99	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	0.50713395
100	P300_19829295_ChIP-Seq_ESCs_Human	0.50523106

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006082_CNS_inflammation	5.47907265
2	MP0000467_abnormal_esophagus_morphology	3.35971081
3	MP0001664_abnormal_digestion	3.22270337
4	MP0001663_abnormal_digestive_system	3.11676923
5	MP0001919_abnormal_reproductive_system	2.64534187
6	MP0003115_abnormal_respiratory_system	2.60565483
7	MP0002751_abnormal_autonomic_nervous	2.53464407
8	MP0000383_abnormal_hair_follicle	2.49832489
9	MP0005381_digestive/alimentary_phenotyp	2.41335211
10	MP0000566_synostosis	13.0653008
11	MP0003303_peritoneal_inflammation	10.1034596
12	MP0005166_decreased_susceptibility_to	1.78133851
13	MP0001915_intracranial_hemorrhage	1.74099876
14	MP0010678_abnormal_skin_adnexa	1.72584182
15	MP0002876_abnormal_thyroid_physiology	1.72271584
16	MP0003453_abnormal_keratinocyte_physiol	1.60893259
17	MP0000534_abnormal_ureter_morphology	1.59625159
18	MP0003937_abnormal_limbs/digits/tail_de	1.57919876
19	MP0005389_reproductive_system_phenotype	1.53129030
20	MP0005397_hematopoietic_system_phenotyp	1.52818852
21	MP0001545_abnormal_hematopoietic_system	1.52818852
22	MP0005076_abnormal_cell_differentiation	1.51260314
23	MP0000428_abnormal_craniofacial_morphol	1.40560998
24	MP0005501_abnormal_skin_physiology	1.19507906
25	MP0003763_abnormal_thymus_physiology	1.10392864
26	MP0000858_altered_metastatic_potential	1.08605234
27	MP0000490_abnormal_crypts_of	1.08539067
28	MP0001286_abnormal_eye_development	1.06899696
29	MP0001293_anophthalmia	1.02478474
30	MP0003329_amyloid_beta_deposits	0.97593628
31	MP0002019_abnormal_tumor_incidence	0.89737996
32	MP0002109_abnormal_limb_morphology	0.86641247
33	MP0000470_abnormal_stomach_morphology	0.84003403
34	MP0001963_abnormal_hearing_physiology	0.81482716
35	MP0002115_abnormal_skeleton_extremities	0.81378260
36	MP0001764_abnormal_homeostasis	0.81063490
37	MP0000026_abnormal_inner_ear	0.78253307
38	MP0003942_abnormal_urinary_system	0.76535950
39	MP0000358_abnormal_cell_content/	0.75035188
40	MP0001986_abnormal_taste_sensitivity	0.72531498
41	MP0010155_abnormal_intestine_physiology	0.71726547
42	MP0005197_abnormal_uvea_morphology	0.66606492
43	MP0000477_abnormal_intestine_morphology	0.65057951
44	MP0009763_increased_sensitivity_to	0.64279614
45	MP0005423_abnormal_somatic_nervous	0.63989998
46	MP0002405_respiratory_system_inflammati	0.63030162
47	MP0000604_amyloidosis	0.62642192
48	MP0005508_abnormal_skeleton_morphology	0.62455215
49	MP0000432_abnormal_head_morphology	0.60870082
50	MP0009672_abnormal_birth_weight	0.59821587
51	MP0002210_abnormal_sex_determination	0.56863675
52	MP0005023_abnormal_wound_healing	0.56254853
53	MP0002184_abnormal_innervation	0.53604042
54	MP0001175_abnormal_lung_morphology	0.53344449
55	MP0000681_abnormal_thyroid_gland	0.52903426
56	MP0003935_abnormal_craniofacial_develop	0.51427683
57	MP0000377_abnormal_hair_follicle	0.47404977
58	MP0002113_abnormal_skeleton_development	0.46975789
59	MP0005253_abnormal_eye_physiology	0.45745194
60	MP0008058_abnormal_DNA_repair	0.43607250
61	MP0003448_altered_tumor_morphology	0.42969843
62	MP0005410_abnormal_fertilization	0.40172667
63	MP0003878_abnormal_ear_physiology	0.38523586
64	MP0005377_hearing/vestibular/ear_phenot	0.38523586
65	MP0003638_abnormal_response/metabolism_	0.37344555
66	MP0000627_abnormal_mammary_gland	0.37325223
67	MP0003136_yellow_coat_color	0.37246269
68	MP0005391_vision/eye_phenotype	0.35851756
69	MP0002735_abnormal_chemical_nociception	0.35405556
70	MP0000163_abnormal_cartilage_morphology	0.33552979
71	MP0003936_abnormal_reproductive_system	0.33400925
72	MP0002136_abnormal_kidney_physiology	0.32957668
73	MP0005025_abnormal_response_to	0.32698177
74	MP0002697_abnormal_eye_size	0.32103863
75	MP0000350_abnormal_cell_proliferation	0.30595567
76	MP0002822_catalepsy	0.29036394
77	MP0002752_abnormal_somatic_nervous	0.28260008
78	MP0010771_integument_phenotype	0.27510405
79	MP0008004_abnormal_stomach_pH	0.27301648
80	MP0002168_other_aberrant_phenotype	0.27244601
81	MP0004197_abnormal_fetal_growth/weight/	0.24678674
82	MP0002452_abnormal_antigen_presenting	0.24479642
83	MP0005390_skeleton_phenotype	0.23355541
84	MP0002161_abnormal_fertility/fecundity	0.21982878
85	MP0004019_abnormal_vitamin_homeostasis	0.19038188
86	MP0001929_abnormal_gametogenesis	0.18728140
87	MP0009931_abnormal_skin_appearance	0.18530698
88	MP0003077_abnormal_cell_cycle	0.17582615
89	MP0003880_abnormal_central_pattern	0.17557671
90	MP0002736_abnormal_nociception_after	0.17499722
91	MP0002092_abnormal_eye_morphology	0.17441685
92	MP0005332_abnormal_amino_acid	0.17197147
93	MP0003091_abnormal_cell_migration	0.16985975
94	MP0002116_abnormal_craniofacial_bone	0.16133236
95	MP0002081_perinatal_lethality	0.16082859
96	MP0006276_abnormal_autonomic_nervous	0.15967885
97	MP0000955_abnormal_spinal_cord	0.15787555
98	MP0003195_calcinosis	0.15657678
99	MP0005000_abnormal_immune_tolerance	0.15354133
100	MP0000049_abnormal_middle_ear	0.13309613

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Duplicated collecting system (HP:0000081)	9.28607113
2	Long foot (HP:0001833)	9.10633931
3	Abnormality of the renal collecting system (HP:0004742)	8.30122593
4	Acute lymphatic leukemia (HP:0006721)	7.22117620
5	Large for gestational age (HP:0001520)	7.21700650
6	Progressive muscle weakness (HP:0003323)	6.78074832
7	Adactyly (HP:0009776)	6.68185006
8	Hypoplastic pelvis (HP:0008839)	6.21634895
9	Abnormality of fatty-acid metabolism (HP:0004359)	6.14940930
10	Autoamputation (HP:0001218)	5.86216720
11	Dry hair (HP:0011359)	5.79435982
12	Pulmonary artery stenosis (HP:0004415)	5.60062555
13	Ureteral stenosis (HP:0000071)	5.56050743
14	Menstrual irregularities (HP:0000858)	5.44629556
15	Steatorrhea (HP:0002570)	5.27851364
16	Ureteral obstruction (HP:0006000)	5.14935196
17	Ureteral duplication (HP:0000073)	5.08247324
18	Brushfield spots (HP:0001088)	5.06273262
19	Hypoplastic nipples (HP:0002557)	4.88644495
20	Abnormal auditory evoked potentials (HP:0006958)	4.60530232
21	Sudden death (HP:0001699)	4.45851471
22	Abnormal ventriculo-arterial connection (HP:0011563)	4.35669756
23	Transposition of the great arteries (HP:0001669)	4.35669756
24	Abnormal connection of the cardiac segments (HP:0011545)	4.35669756
25	Reduced subcutaneous adipose tissue (HP:0003758)	4.34325357
26	Fat malabsorption (HP:0002630)	4.09661321
27	Increased number of teeth (HP:0011069)	4.07285722
28	Severe muscular hypotonia (HP:0006829)	4.06564953
29	Decreased lacrimation (HP:0000633)	3.99028125
30	Anhidrosis (HP:0000970)	3.96478094
31	Palmoplantar hyperkeratosis (HP:0000972)	3.81119668
32	Broad-based gait (HP:0002136)	3.68558400
33	Palmar hyperkeratosis (HP:0010765)	3.60767209
34	Abnormality of vision evoked potentials (HP:0000649)	3.44061284
35	Polyneuropathy (HP:0001271)	3.35448678
36	Wide intermamillary distance (HP:0006610)	3.33024589
37	Broad nasal tip (HP:0000455)	3.29532368
38	Generalized amyotrophy (HP:0003700)	3.28309373
39	Large hands (HP:0001176)	3.24162914
40	Decreased muscle mass (HP:0003199)	3.15800375
41	Myoglobinuria (HP:0002913)	3.11544484
42	Plantar hyperkeratosis (HP:0007556)	3.07751536
43	Rhabdomyolysis (HP:0003201)	3.05199040
44	Polymicrogyria (HP:0002126)	2.99359555
45	Clubbing of toes (HP:0100760)	2.72058260
46	Flat face (HP:0012368)	2.65926683
47	Steppage gait (HP:0003376)	2.60302848
48	Epiphyseal stippling (HP:0010655)	2.55296461
49	Chorioretinal coloboma (HP:0000567)	2.52103103
50	Hypoplastic iliac wings (HP:0002866)	2.50792857
51	Overfolded helix (HP:0000396)	2.46397690
52	Widely spaced teeth (HP:0000687)	2.44172806
53	Basal ganglia calcification (HP:0002135)	2.37825280
54	Thickened calvaria (HP:0002684)	2.37240614
55	Purpura (HP:0000979)	2.36349035
56	Posterior embryotoxon (HP:0000627)	2.27707229
57	Abnormally folded helix (HP:0008544)	2.24990755
58	Foot dorsiflexor weakness (HP:0009027)	2.19858354
59	Abnormality of the line of Schwalbe (HP:0008048)	2.19335768
60	Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)	2.15017480
61	Anxiety (HP:0000739)	2.13442273
62	Absent toe (HP:0010760)	2.11219736
63	Aplasia/Hypoplasia of the nipples (HP:0006709)	2.09849407
64	Female pseudohermaphroditism (HP:0010458)	2.07723684
65	Hammertoe (HP:0001765)	2.02640645
66	Abnormality of the foot musculature (HP:0001436)	2.00195313
67	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	12.1551829
68	Prenatal maternal abnormality (HP:0002686)	1.95724306
69	Stereotypic behavior (HP:0000733)	1.94191913
70	External ear malformation (HP:0008572)	1.93705799
71	Thickened nuchal skin fold (HP:0000474)	1.89115805
72	Abnormality of the epiphyses of the hand (HP:0005924)	1.87392700
73	Generalized muscle weakness (HP:0003324)	1.86546803
74	Spastic tetraplegia (HP:0002510)	1.84969002
75	Congenital onset (HP:0003577)	1.83005714
76	Primary adrenal insufficiency (HP:0008207)	1.82182785
77	Gangrene (HP:0100758)	1.81542552
78	Abnormal epiphyseal ossification (HP:0010656)	1.80172601
79	Arthrogryposis multiplex congenita (HP:0002804)	1.78405328
80	Decreased motor nerve conduction velocity (HP:0003431)	1.78236405
81	Arterial thrombosis (HP:0004420)	1.76229356
82	Abnormality involving the epiphyses of the upper limbs (HP:0003839)	1.76093211
83	Decreased number of peripheral myelinated nerve fibers (HP:0003380)	1.72221867
84	Brachycephaly (HP:0000248)	1.65542304
85	Short philtrum (HP:0000322)	1.58304696
86	Depressed nasal ridge (HP:0000457)	1.57800418
87	Underdeveloped supraorbital ridges (HP:0009891)	1.55099633
88	Aplasia/Hypoplasia involving the pelvis (HP:0009103)	1.54770269
89	Nail dystrophy (HP:0008404)	1.54354752
90	Scrotal hypoplasia (HP:0000046)	1.48221390
91	Hypoplastic ilia (HP:0000946)	1.47700122
92	Abnormality of primary teeth (HP:0006481)	1.38277812
93	Opacification of the corneal stroma (HP:0007759)	1.35238986
94	Pulmonary embolism (HP:0002204)	1.34775131
95	Respiratory insufficiency due to muscle weakness (HP:0002747)	1.34037812
96	Lactic acidosis (HP:0003128)	1.33117290
97	Retinopathy (HP:0000488)	1.32107418
98	Webbed neck (HP:0000465)	1.28486230
99	Freckling (HP:0001480)	1.27083193
100	Postnatal growth retardation (HP:0008897)	1.25360954

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MKNK1	6.84182713
2	TAOK2	5.58014758
3	TAOK1	5.50981372
4	MAP3K3	4.14782216
5	MAP2K3	4.02187312
6	MAP3K11	3.98587486
7	JAK3	2.46206964
8	MKNK2	11.5552025
9	ABL2	1.87004105
10	DYRK1A	1.75574456
11	MAP3K5	1.33116808
12	MAP3K1	1.05811950
13	SRPK1	0.98680635
14	CHEK2	0.81457650
15	MAP3K8	0.68947840
16	PRKCQ	0.47078007
17	INSRR	0.22682288
18	PLK4	0.19622542
19	CSNK1A1	0.19280077
20	ABL1	0.15161979
21	MAP4K2	0.13141446
22	IGF1R	0.13054753
23	OBSCN	0.09884153
24	MUSK	0.09412358
25	PIK3CG	0.08387789
26	MAPK15	0.07193803
27	PRKCD	0.06780785
28	WNK3	0.05280200
29	CSNK2A2	0.04766714
30	TIE1	0.04739036
31	GRK7	0.04680017
32	FRK	0.03764977
33	TXK	0.03127649
34	CSNK1E	0.02170350
35	CSNK2A1	0.02123468
36	PDK2	0.01773515
37	GRK1	0.01493273
38	EPHA4	0.00806087
39	ADRBK2	0.00751098
40	DDR2	0.00482527
41	PRKCA	0.00269831
42	RIPK4	-0.1261224
43	UHMK1	-0.1260533
44	CSK	-0.1260026
45	EGFR	-0.1254747
46	PINK1	-0.1238256
47	PRKACG	-0.1211979
48	MAPK7	-0.1207070
49	MOS	-0.1193546
50	CDK3	-0.1176745
51	IKBKE	-0.1169152
52	MAPK4	-0.1131239
53	PIM1	-0.1129967
54	PRKCE	-0.1110888
55	STK39	-0.1103135
56	CDK1	-0.1100062
57	CAMK2G	-0.1094430
58	LYN	-0.1086961
59	MAP2K6	-0.1066570
60	ADRBK1	-0.1061612
61	BRD4	-0.1048243
62	PRKG1	-0.1022406
63	PIK3CA	-0.1002500
64	SYK	-0.1002215
65	PRKG2	-0.0990113
66	CAMK2A	-0.0983253
67	PIM2	-0.0982272
68	OXSR1	-0.0979304
69	BTK	-0.0956587
70	TLK1	-0.0954924
71	PHKG2	-0.0930638
72	PHKG1	-0.0930638
73	WNK4	-0.0928084
74	PRKCG	-0.0917957
75	MAPK14	-0.0916481
76	PLK2	-0.0904422
77	PKN1	-0.0868288
78	GRK6	-0.0861245
79	PRKD3	-0.0857372
80	EPHA2	-0.0837341
81	NTRK2	-0.0818083
82	GRK5	-0.0753441
83	CDK2	-0.0714147
84	ITK	-0.0708421
85	TNK2	-0.0707888
86	LMTK2	-0.0637172
87	STK38L	-0.0631826
88	TEC	-0.0546004
89	KDR	-0.0542349
90	KIT	-0.0516684
91	TTN	-0.0494938
92	MATK	-0.0483331
93	NEK6	-0.0376874
94	SRC	-0.0305143
95	PRKACA	-0.0271362
96	MST1R	-0.0270194
97	BLK	-0.0246977
98	PRKCB	-0.0104679
99	ERBB4	-0.0086610
100	AURKA	-0.0031412

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	8.60842750
2	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	7.25639939
3	Taste transduction_Homo sapiens_hsa04742	3.18627690
4	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.08389566
5	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	3.05912168
6	RNA polymerase_Homo sapiens_hsa03020	2.96326822
7	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.77461518
8	Lysine degradation_Homo sapiens_hsa00310	2.70950538
9	Fatty acid elongation_Homo sapiens_hsa00062	2.65933322
10	Butanoate metabolism_Homo sapiens_hsa00650	2.51681277
11	beta-Alanine metabolism_Homo sapiens_hsa00410	2.02374611
12	Glycerolipid metabolism_Homo sapiens_hsa00561	1.90747964
13	Amoebiasis_Homo sapiens_hsa05146	1.90329004
14	Tryptophan metabolism_Homo sapiens_hsa00380	1.74518237
15	One carbon pool by folate_Homo sapiens_hsa00670	1.59650368
16	Propanoate metabolism_Homo sapiens_hsa00640	1.47679056
17	Proteasome_Homo sapiens_hsa03050	1.36572419
18	Viral myocarditis_Homo sapiens_hsa05416	1.21095524
19	Fatty acid degradation_Homo sapiens_hsa00071	1.19753525
20	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	1.18846701
21	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.15121141
22	Fatty acid metabolism_Homo sapiens_hsa01212	1.00547727
23	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.95067948
24	Complement and coagulation cascades_Homo sapiens_hsa04610	0.93495246
25	Olfactory transduction_Homo sapiens_hsa04740	0.84356741
26	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.84117150
27	Peroxisome_Homo sapiens_hsa04146	0.77301738
28	AMPK signaling pathway_Homo sapiens_hsa04152	0.71594156
29	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.69322706
30	MicroRNAs in cancer_Homo sapiens_hsa05206	0.68711032
31	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.68570949
32	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.68254920
33	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.66870799
34	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.65147954
35	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.64731432
36	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.61044939
37	Choline metabolism in cancer_Homo sapiens_hsa05231	0.58096808
38	Caffeine metabolism_Homo sapiens_hsa00232	0.54721659
39	Cholinergic synapse_Homo sapiens_hsa04725	0.54035645
40	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.51930970
41	Nicotine addiction_Homo sapiens_hsa05033	0.50919964
42	Pyrimidine metabolism_Homo sapiens_hsa00240	0.50438183
43	Salmonella infection_Homo sapiens_hsa05132	0.48950595
44	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.47100667
45	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.46478614
46	Retinol metabolism_Homo sapiens_hsa00830	0.44978935
47	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.44936211
48	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.44294465
49	GnRH signaling pathway_Homo sapiens_hsa04912	0.43796812
50	Graft-versus-host disease_Homo sapiens_hsa05332	0.43524399
51	Asthma_Homo sapiens_hsa05310	0.42926564
52	TNF signaling pathway_Homo sapiens_hsa04668	0.42060993
53	Toxoplasmosis_Homo sapiens_hsa05145	0.41577535
54	Allograft rejection_Homo sapiens_hsa05330	0.39121706
55	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.37767517
56	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.37390585
57	RNA transport_Homo sapiens_hsa03013	0.36195590
58	Protein digestion and absorption_Homo sapiens_hsa04974	0.36105482
59	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.35868117
60	Linoleic acid metabolism_Homo sapiens_hsa00591	0.33282550
61	Malaria_Homo sapiens_hsa05144	0.32855449
62	Nucleotide excision repair_Homo sapiens_hsa03420	0.32165275
63	Type I diabetes mellitus_Homo sapiens_hsa04940	0.31859157
64	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.30029290
65	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.29374528
66	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.28643659
67	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.27596860
68	ECM-receptor interaction_Homo sapiens_hsa04512	0.27251118
69	Chemical carcinogenesis_Homo sapiens_hsa05204	0.25997370
70	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.25672460
71	Purine metabolism_Homo sapiens_hsa00230	0.25307629
72	Tyrosine metabolism_Homo sapiens_hsa00350	0.24305557
73	Phototransduction_Homo sapiens_hsa04744	0.23846236
74	Phenylalanine metabolism_Homo sapiens_hsa00360	0.23508759
75	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.23386323
76	Phagosome_Homo sapiens_hsa04145	0.22940541
77	Fat digestion and absorption_Homo sapiens_hsa04975	0.22591384
78	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.22499594
79	Bile secretion_Homo sapiens_hsa04976	0.21744874
80	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.20646299
81	African trypanosomiasis_Homo sapiens_hsa05143	0.19173296
82	Nitrogen metabolism_Homo sapiens_hsa00910	0.16810384
83	Tuberculosis_Homo sapiens_hsa05152	0.15804432
84	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.15462033
85	MAPK signaling pathway_Homo sapiens_hsa04010	0.14926125
86	Influenza A_Homo sapiens_hsa05164	0.13844316
87	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.13593472
88	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.13189249
89	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.12667212
90	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.12655378
91	Primary immunodeficiency_Homo sapiens_hsa05340	0.11301209
92	Rap1 signaling pathway_Homo sapiens_hsa04015	0.10396391
93	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.10322395
94	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.09843309
95	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.09830112
96	Renin-angiotensin system_Homo sapiens_hsa04614	0.09521205
97	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.08315908
98	ABC transporters_Homo sapiens_hsa02010	0.06927186
99	Calcium signaling pathway_Homo sapiens_hsa04020	0.06833422
100	Salivary secretion_Homo sapiens_hsa04970	0.06247279

GAPDHP52

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »