ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of action potential (GO:0045760)	9.47857240
2	positive regulation of uterine smooth muscle contraction (GO:0070474)	9.24410175
3	positive regulation of vascular permeability (GO:0043117)	7.75934494
4	regulation of uterine smooth muscle contraction (GO:0070472)	7.35434604
5	drinking behavior (GO:0042756)	7.30463852
6	urinary tract smooth muscle contraction (GO:0014848)	7.10518610
7	positive regulation of digestive system process (GO:0060456)	6.65238630
8	aggressive behavior (GO:0002118)	6.61599111
9	positive regulation of synaptic transmission, GABAergic (GO:0032230)	5.90774182
10	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	5.55215548
11	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	5.55215548
12	regulation of action potential (GO:0098900)	5.31323345
13	behavioral response to pain (GO:0048266)	5.02492672
14	folic acid-containing compound biosynthetic process (GO:0009396)	4.97856432
15	positive regulation of renal sodium excretion (GO:0035815)	4.77554891
16	proteasome assembly (GO:0043248)	4.56915264
17	terpenoid biosynthetic process (GO:0016114)	4.44844398
18	adenosine metabolic process (GO:0046085)	4.42318676
19	diterpenoid biosynthetic process (GO:0016102)	4.38727981
20	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	4.32672136
21	response to auditory stimulus (GO:0010996)	4.24171843
22	righting reflex (GO:0060013)	4.20698139
23	microtubule nucleation (GO:0007020)	4.15890717
24	adaptation of signaling pathway (GO:0023058)	3.85338157
25	amino acid salvage (GO:0043102)	3.85185051
26	L-methionine salvage (GO:0071267)	3.85185051
27	L-methionine biosynthetic process (GO:0071265)	3.85185051
28	purine nucleotide salvage (GO:0032261)	3.81361671
29	protein-cofactor linkage (GO:0018065)	3.78104451
30	water-soluble vitamin biosynthetic process (GO:0042364)	3.75085838
31	IMP biosynthetic process (GO:0006188)	3.73887275
32	rRNA modification (GO:0000154)	3.71736406
33	rRNA methylation (GO:0031167)	3.66108837
34	adult feeding behavior (GO:0008343)	3.54835705
35	pteridine-containing compound biosynthetic process (GO:0042559)	3.50000025
36	mitochondrial RNA metabolic process (GO:0000959)	3.49720833
37	regulation of synaptic transmission, GABAergic (GO:0032228)	3.44972088
38	platelet dense granule organization (GO:0060155)	3.39041236
39	homocysteine metabolic process (GO:0050667)	3.35413186
40	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.34381640
41	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.34381640
42	NADH dehydrogenase complex assembly (GO:0010257)	3.34381640
43	sulfur amino acid biosynthetic process (GO:0000097)	3.34287823
44	methionine metabolic process (GO:0006555)	3.33701870
45	behavioral defense response (GO:0002209)	3.30681972
46	behavioral fear response (GO:0001662)	3.30681972
47	response to pheromone (GO:0019236)	3.30328809
48	L-serine metabolic process (GO:0006563)	3.23265493
49	IMP metabolic process (GO:0046040)	3.21740817
50	pseudouridine synthesis (GO:0001522)	3.09068370
51	regulation of plasminogen activation (GO:0010755)	3.05537827
52	kinetochore assembly (GO:0051382)	3.04826829
53	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.99872529
54	DNA double-strand break processing (GO:0000729)	2.97784223
55	positive regulation of smooth muscle contraction (GO:0045987)	2.97201758
56	CENP-A containing nucleosome assembly (GO:0034080)	2.96985046
57	methionine biosynthetic process (GO:0009086)	2.96115383
58	regulation of cellular amino acid metabolic process (GO:0006521)	2.93559879
59	protein complex biogenesis (GO:0070271)	2.93034693
60	isoprenoid biosynthetic process (GO:0008299)	2.92454503
61	respiratory chain complex IV assembly (GO:0008535)	2.91998322
62	inner ear receptor cell development (GO:0060119)	2.90227774
63	regulation of cilium movement (GO:0003352)	2.88251496
64	regulation of microtubule-based movement (GO:0060632)	2.88027841
65	regulation of gonadotropin secretion (GO:0032276)	2.87945611
66	protein-chromophore linkage (GO:0018298)	2.87319869
67	fear response (GO:0042596)	2.87182225
68	mitochondrial respiratory chain complex assembly (GO:0033108)	2.87116591
69	kinetochore organization (GO:0051383)	2.87085738
70	replication fork processing (GO:0031297)	2.86706884
71	cysteine metabolic process (GO:0006534)	2.85688445
72	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.84262247
73	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.80993134
74	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.80993134
75	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.80993134
76	sulfur amino acid catabolic process (GO:0000098)	2.79971872
77	regulation of renal sodium excretion (GO:0035813)	2.79420191
78	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.77947795
79	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.77947795
80	positive regulation of inositol phosphate biosynthetic process (GO:0060732)	2.75865135
81	behavioral response to ethanol (GO:0048149)	2.73743338
82	purine nucleobase biosynthetic process (GO:0009113)	2.73162404
83	chromatin remodeling at centromere (GO:0031055)	2.73099816
84	regulation of digestive system process (GO:0044058)	2.73059942
85	positive regulation of guanylate cyclase activity (GO:0031284)	2.71625815
86	tRNA modification (GO:0006400)	2.71064186
87	white fat cell differentiation (GO:0050872)	2.70692881
88	cochlea development (GO:0090102)	2.69888927
89	eating behavior (GO:0042755)	2.68937192
90	negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)	2.68560763
91	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.66081438
92	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.63327391
93	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.63327391
94	tRNA processing (GO:0008033)	2.63035811
95	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.61983372
96	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.61012870
97	histone exchange (GO:0043486)	2.58568564
98	aspartate family amino acid biosynthetic process (GO:0009067)	2.56364549
99	protein neddylation (GO:0045116)	2.55756709
100	tachykinin receptor signaling pathway (GO:0007217)	10.4688898

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	8.78776201
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.95117461
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.35502025
4	ZNF274_21170338_ChIP-Seq_K562_Hela	3.23229154
5	VDR_22108803_ChIP-Seq_LS180_Human	3.09168454
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.98303506
7	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.87389499
8	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.73926212
9	GBX2_23144817_ChIP-Seq_PC3_Human	2.44438880
10	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.37387211
11	GATA1_22025678_ChIP-Seq_K562_Human	2.35200915
12	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.30622459
13	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.29546230
14	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.23238129
15	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.05386608
16	ELK1_19687146_ChIP-ChIP_HELA_Human	2.04736586
17	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.99647830
18	FUS_26573619_Chip-Seq_HEK293_Human	1.94759741
19	E2F7_22180533_ChIP-Seq_HELA_Human	1.94422471
20	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.94254863
21	TAF15_26573619_Chip-Seq_HEK293_Human	1.93219677
22	P300_19829295_ChIP-Seq_ESCs_Human	1.90335643
23	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.86745391
24	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.80465156
25	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.79594758
26	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.76382432
27	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.75076088
28	EWS_26573619_Chip-Seq_HEK293_Human	1.74352427
29	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.73407658
30	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.67971130
31	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.67598027
32	CBP_20019798_ChIP-Seq_JUKART_Human	1.65831459
33	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.65831459
34	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.62624148
35	VDR_23849224_ChIP-Seq_CD4+_Human	1.56658664
36	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.51237994
37	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.48111890
38	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.48063204
39	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.45916741
40	IGF1R_20145208_ChIP-Seq_DFB_Human	1.39762304
41	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.39288133
42	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.37703679
43	TP53_22573176_ChIP-Seq_HFKS_Human	1.37383361
44	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.37186872
45	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.35253276
46	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.34791038
47	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.31916269
48	FOXP3_21729870_ChIP-Seq_TREG_Human	1.31421471
49	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.30959632
50	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.30753288
51	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.29767456
52	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.27219053
53	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.24894603
54	ER_23166858_ChIP-Seq_MCF-7_Human	1.22912321
55	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.18238064
56	SMAD4_21799915_ChIP-Seq_A2780_Human	1.18057081
57	SOX9_26525672_Chip-Seq_Limbbuds_Mouse	1.17071683
58	TCF4_22108803_ChIP-Seq_LS180_Human	1.16181633
59	BCAT_22108803_ChIP-Seq_LS180_Human	1.13401691
60	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.13090071
61	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.12717004
62	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.11602554
63	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.11432437
64	AR_25329375_ChIP-Seq_VCAP_Human	1.10920949
65	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.10665224
66	GABP_19822575_ChIP-Seq_HepG2_Human	1.10463408
67	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.10458105
68	NCOR_22424771_ChIP-Seq_293T_Human	1.09592209
69	SOX2_19829295_ChIP-Seq_ESCs_Human	1.08897339
70	NANOG_19829295_ChIP-Seq_ESCs_Human	1.08897339
71	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.08564007
72	STAT3_23295773_ChIP-Seq_U87_Human	1.08327404
73	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.06750312
74	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.05678293
75	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.05000199
76	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.03673698
77	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.01661848
78	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.01262320
79	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.00076163
80	PHF8_20622853_ChIP-Seq_HELA_Human	0.99616429
81	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.96064062
82	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.95642028
83	RUNX2_22187159_ChIP-Seq_PCA_Human	0.94644226
84	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.94536553
85	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.94336150
86	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.93955573
87	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.92507183
88	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	0.91156809
89	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.90276261
90	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.90276261
91	EZH2_22144423_ChIP-Seq_EOC_Human	0.90016484
92	TCF4_23295773_ChIP-Seq_U87_Human	0.89343878
93	JUN_21703547_ChIP-Seq_K562_Human	0.88983689
94	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.86675140
95	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.85108916
96	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.84924049
97	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.84664542
98	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.84337797
99	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.83370661
100	AR_21572438_ChIP-Seq_LNCaP_Human	0.82787250

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002736_abnormal_nociception_after	6.21320297
2	MP0001529_abnormal_vocalization	4.98422630
3	MP0001968_abnormal_touch/_nociception	4.66956557
4	MP0002277_abnormal_respiratory_mucosa	4.66031054
5	MP0002735_abnormal_chemical_nociception	4.35418723
6	MP0004147_increased_porphyrin_level	3.71511904
7	MP0002938_white_spotting	3.28014075
8	MP0008872_abnormal_physiological_respon	2.72745178
9	MP0005360_urolithiasis	2.60891649
10	MP0003183_abnormal_peptide_metabolism	2.44093894
11	MP0002138_abnormal_hepatobiliary_system	2.39250437
12	MP0003718_maternal_effect	2.36867083
13	MP0000372_irregular_coat_pigmentation	2.21419343
14	MP0002734_abnormal_mechanical_nocicepti	2.08362807
15	MP0003880_abnormal_central_pattern	2.06428115
16	MP0003136_yellow_coat_color	1.96878380
17	MP0009780_abnormal_chondrocyte_physiolo	1.89906510
18	MP0005174_abnormal_tail_pigmentation	1.87503769
19	MP0005646_abnormal_pituitary_gland	1.73155684
20	MP0005171_absent_coat_pigmentation	1.70817469
21	MP0003195_calcinosis	1.65231988
22	MP0002095_abnormal_skin_pigmentation	1.63679477
23	MP0008058_abnormal_DNA_repair	1.57643863
24	MP0008995_early_reproductive_senescence	1.55123144
25	MP0005623_abnormal_meninges_morphology	1.54843844
26	MP0001661_extended_life_span	1.53204625
27	MP0005551_abnormal_eye_electrophysiolog	1.49976575
28	MP0000647_abnormal_sebaceous_gland	1.48296240
29	MP0003252_abnormal_bile_duct	1.45794387
30	MP0002234_abnormal_pharynx_morphology	1.40247144
31	MP0009745_abnormal_behavioral_response	1.38439526
32	MP0009697_abnormal_copulation	1.37064254
33	MP0000569_abnormal_digit_pigmentation	1.36910328
34	MP0003693_abnormal_embryo_hatching	1.27487697
35	MP0002272_abnormal_nervous_system	1.25127423
36	MP0005084_abnormal_gallbladder_morpholo	1.22146735
37	MP0003950_abnormal_plasma_membrane	1.17745975
38	MP0010094_abnormal_chromosome_stability	1.13369610
39	MP0005395_other_phenotype	1.13098244
40	MP0003646_muscle_fatigue	1.11881469
41	MP0004885_abnormal_endolymph	1.10865183
42	MP0002933_joint_inflammation	1.09396354
43	MP0002067_abnormal_sensory_capabilities	1.07969042
44	MP0004270_analgesia	1.05489064
45	MP0002572_abnormal_emotion/affect_behav	1.04835655
46	MP0009046_muscle_twitch	1.04292801
47	MP0003656_abnormal_erythrocyte_physiolo	1.03139964
48	MP0001970_abnormal_pain_threshold	1.02392454
49	MP0003186_abnormal_redox_activity	1.01756801
50	MP0002102_abnormal_ear_morphology	1.01756237
51	MP0005386_behavior/neurological_phenoty	1.01014205
52	MP0004924_abnormal_behavior	1.01014205
53	MP0000015_abnormal_ear_pigmentation	0.99524427
54	MP0002139_abnormal_hepatobiliary_system	0.99116296
55	MP0000631_abnormal_neuroendocrine_gland	0.98576964
56	MP0004145_abnormal_muscle_electrophysio	0.95333656
57	MP0005670_abnormal_white_adipose	0.93974447
58	MP0003635_abnormal_synaptic_transmissio	0.92984871
59	MP0002396_abnormal_hematopoietic_system	0.92668382
60	MP0002751_abnormal_autonomic_nervous	0.92049120
61	MP0008789_abnormal_olfactory_epithelium	0.91428258
62	MP0003806_abnormal_nucleotide_metabolis	0.89088146
63	MP0005394_taste/olfaction_phenotype	0.86292966
64	MP0005499_abnormal_olfactory_system	0.86292966
65	MP0005310_abnormal_salivary_gland	0.82938102
66	MP0001486_abnormal_startle_reflex	0.81988791
67	MP0002837_dystrophic_cardiac_calcinosis	0.79863671
68	MP0004859_abnormal_synaptic_plasticity	0.79792905
69	MP0005085_abnormal_gallbladder_physiolo	0.78383840
70	MP0006036_abnormal_mitochondrial_physio	0.76185547
71	MP0000013_abnormal_adipose_tissue	0.73703512
72	MP0003786_premature_aging	0.73606546
73	MP0005253_abnormal_eye_physiology	0.73436320
74	MP0002928_abnormal_bile_duct	0.72111716
75	MP0001764_abnormal_homeostasis	0.72091339
76	MP0003111_abnormal_nucleus_morphology	0.69597930
77	MP0004142_abnormal_muscle_tone	0.68170577
78	MP0003633_abnormal_nervous_system	0.67309173
79	MP0008875_abnormal_xenobiotic_pharmacok	0.66701716
80	MP0002233_abnormal_nose_morphology	0.66197589
81	MP0001905_abnormal_dopamine_level	0.65481698
82	MP0006276_abnormal_autonomic_nervous	0.65214976
83	MP0005408_hypopigmentation	0.64335389
84	MP0003937_abnormal_limbs/digits/tail_de	0.64118621
85	MP0005332_abnormal_amino_acid	0.63656799
86	MP0000371_diluted_coat_color	0.63323839
87	MP0003045_fibrosis	0.63274994
88	MP0005367_renal/urinary_system_phenotyp	0.63043691
89	MP0000516_abnormal_urinary_system	0.63043691
90	MP0005187_abnormal_penis_morphology	0.62607988
91	MP0001984_abnormal_olfaction	0.62601879
92	MP0000026_abnormal_inner_ear	0.60958350
93	MP0004043_abnormal_pH_regulation	0.60627417
94	MP0001756_abnormal_urination	0.60449990
95	MP0000749_muscle_degeneration	0.60399516
96	MP0005195_abnormal_posterior_eye	0.59201091
97	MP0002557_abnormal_social/conspecific_i	0.58949295
98	MP0003755_abnormal_palate_morphology	0.58693177
99	MP0001293_anophthalmia	0.58230805
100	MP0004484_altered_response_of	0.58132071

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of alanine metabolism (HP:0010916)	4.62500813
2	Hyperalaninemia (HP:0003348)	4.62500813
3	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	4.62500813
4	Congenital sensorineural hearing impairment (HP:0008527)	3.93338126
5	Decreased electroretinogram (ERG) amplitude (HP:0000654)	3.79823472
6	Constricted visual fields (HP:0001133)	3.78604129
7	Increased serum pyruvate (HP:0003542)	3.25168057
8	Abnormality of glycolysis (HP:0004366)	3.21305909
9	Abnormality of the labia minora (HP:0012880)	3.20900256
10	Abnormality of the pons (HP:0007361)	3.11185413
11	Type I transferrin isoform profile (HP:0003642)	2.98154145
12	Abnormality of serum amino acid levels (HP:0003112)	2.96811938
13	Increased hepatocellular lipid droplets (HP:0006565)	2.96756823
14	Hypoproteinemia (HP:0003075)	2.87204869
15	Natal tooth (HP:0000695)	2.86722743
16	Thyroid-stimulating hormone excess (HP:0002925)	2.83860001
17	Atonic seizures (HP:0010819)	2.76723686
18	Abnormality of methionine metabolism (HP:0010901)	2.74997535
19	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.66973003
20	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.65350421
21	Lipid accumulation in hepatocytes (HP:0006561)	2.64647531
22	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.62949153
23	Meckel diverticulum (HP:0002245)	2.61204398
24	Acute encephalopathy (HP:0006846)	2.58681778
25	Renal cortical cysts (HP:0000803)	2.57277921
26	Increased serum lactate (HP:0002151)	2.54921419
27	Abnormality of the ileum (HP:0001549)	2.53520701
28	Mitochondrial inheritance (HP:0001427)	2.53489646
29	Acute necrotizing encephalopathy (HP:0006965)	2.53201713
30	Hyperglycinemia (HP:0002154)	2.50962749
31	Birth length less than 3rd percentile (HP:0003561)	2.49321050
32	Cerebral hypomyelination (HP:0006808)	2.46983516
33	Premature ovarian failure (HP:0008209)	2.46081563
34	Increased CSF lactate (HP:0002490)	2.44295668
35	Action tremor (HP:0002345)	2.43243487
36	Abnormality of the preputium (HP:0100587)	2.40654721
37	Pendular nystagmus (HP:0012043)	2.40313665
38	Duplicated collecting system (HP:0000081)	2.38957753
39	Abnormality of chromosome stability (HP:0003220)	2.37861465
40	Hypoplasia of the pons (HP:0012110)	2.36418594
41	Pancreatic cysts (HP:0001737)	2.35690742
42	Patchy hypopigmentation of hair (HP:0011365)	2.34492915
43	White forelock (HP:0002211)	2.33535892
44	Renal Fanconi syndrome (HP:0001994)	2.32905282
45	Homocystinuria (HP:0002156)	2.31311364
46	Abnormality of homocysteine metabolism (HP:0010919)	2.31311364
47	Abnormality of the renal cortex (HP:0011035)	2.27436499
48	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.26165217
49	Abnormality of the renal collecting system (HP:0004742)	2.23913847
50	Fibular aplasia (HP:0002990)	2.22049244
51	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.21766989
52	Abnormality of sulfur amino acid metabolism (HP:0004339)	2.21384192
53	Methylmalonic aciduria (HP:0012120)	2.14219456
54	Chromsome breakage (HP:0040012)	2.13877962
55	Clubbing of toes (HP:0100760)	2.12151296
56	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.12137265
57	Abnormal protein N-linked glycosylation (HP:0012347)	2.12137265
58	Abnormal protein glycosylation (HP:0012346)	2.12137265
59	Abnormal glycosylation (HP:0012345)	2.12137265
60	Gait imbalance (HP:0002141)	2.11809589
61	Facial cleft (HP:0002006)	2.10364272
62	Methylmalonic acidemia (HP:0002912)	2.06742596
63	Attenuation of retinal blood vessels (HP:0007843)	2.06451915
64	Progressive macrocephaly (HP:0004481)	2.06439180
65	Abolished electroretinogram (ERG) (HP:0000550)	2.03364986
66	True hermaphroditism (HP:0010459)	1.98559617
67	Abnormality of the carotid arteries (HP:0005344)	1.97614978
68	Abnormality of glycine metabolism (HP:0010895)	1.96691131
69	Abnormality of serine family amino acid metabolism (HP:0010894)	1.96691131
70	Abnormal mitochondria in muscle tissue (HP:0008316)	1.96234655
71	Cerebral edema (HP:0002181)	1.95224626
72	Spinal muscular atrophy (HP:0007269)	1.94147064
73	Lactic acidosis (HP:0003128)	1.92113534
74	Anorexia (HP:0002039)	1.90335693
75	Medial flaring of the eyebrow (HP:0010747)	1.89923517
76	Aplasia/hypoplasia of the uterus (HP:0008684)	1.89705803
77	Panhypogammaglobulinemia (HP:0003139)	1.89700735
78	Esophageal varix (HP:0002040)	1.87571021
79	Duodenal stenosis (HP:0100867)	1.86109645
80	Small intestinal stenosis (HP:0012848)	1.86109645
81	Pancreatic fibrosis (HP:0100732)	1.85389068
82	3-Methylglutaconic aciduria (HP:0003535)	1.84811344
83	Abnormality of the fetal cardiovascular system (HP:0010948)	1.84696127
84	Abnormal umbilical cord blood vessels (HP:0011403)	1.84696127
85	Single umbilical artery (HP:0001195)	1.84696127
86	Ileus (HP:0002595)	1.84079676
87	Hepatocellular necrosis (HP:0001404)	1.82872239
88	Chronic otitis media (HP:0000389)	1.81596452
89	Medulloblastoma (HP:0002885)	1.80135706
90	Abnormality of urine glucose concentration (HP:0011016)	1.78898395
91	Glycosuria (HP:0003076)	1.78898395
92	Degeneration of anterior horn cells (HP:0002398)	1.78623448
93	Abnormality of the anterior horn cell (HP:0006802)	1.78623448
94	Chronic hepatic failure (HP:0100626)	1.77133253
95	Aplastic anemia (HP:0001915)	1.76617245
96	Large for gestational age (HP:0001520)	1.75501881
97	Long clavicles (HP:0000890)	1.75285999
98	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	1.72010596
99	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.72010596
100	Hypoplasia of the uterus (HP:0000013)	1.71882766

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TNIK	4.09307270
2	MAPK13	3.62548921
3	VRK2	2.97634818
4	EIF2AK1	2.62095825
5	CCNB1	2.51434642
6	BUB1	2.44107038
7	VRK1	2.35457347
8	EIF2AK3	2.25563220
9	BRSK2	2.23486183
10	TSSK6	2.20722796
11	BMPR1B	2.20572477
12	MARK1	2.19790484
13	ZAK	2.18666820
14	WNK3	1.99522312
15	NUAK1	1.97165023
16	TRIM28	1.95841695
17	BCR	1.95094613
18	NEK9	1.90714267
19	ACVR1B	1.79547846
20	BCKDK	1.77067148
21	MAPKAPK5	1.74409419
22	PLK3	1.71869234
23	MKNK1	1.68861426
24	PAK3	1.59117893
25	PHKG1	1.51849380
26	PHKG2	1.51849380
27	PRKCI	1.42410910
28	EIF2AK2	1.42132981
29	MAP3K12	1.38371028
30	TLK1	1.37089872
31	SIK3	1.28370085
32	BRSK1	1.27089571
33	CASK	1.26642173
34	PBK	1.26131555
35	DYRK2	1.24120435
36	NTRK2	1.22984189
37	PLK2	1.21965813
38	MST4	1.18685977
39	MAP3K3	1.16639881
40	SRPK1	1.11844666
41	TAF1	1.09973946
42	SGK2	1.09439999
43	FER	1.07370525
44	EPHA4	1.01719833
45	FGFR1	0.97599737
46	NTRK3	0.96429200
47	PKN1	0.94675630
48	CAMKK2	0.94437927
49	GRK1	0.94104020
50	PLK4	0.93440730
51	FGR	0.90050632
52	CDK8	0.89825071
53	PRKCE	0.87528518
54	NEK1	0.87452662
55	MARK3	0.86482427
56	DAPK1	0.85618013
57	CDK9	0.82414512
58	SGK223	0.82250167
59	SGK494	0.82250167
60	CSNK1G2	0.81439701
61	TTK	0.79765100
62	TAOK3	0.77403087
63	PRKCG	0.76942526
64	NME1	0.76629644
65	ADRBK1	0.66688084
66	MAP2K1	0.64673874
67	CSNK1G1	0.59904845
68	CSNK1G3	0.59827997
69	CSNK1A1L	0.59638429
70	CAMK2A	0.56286632
71	CAMK2B	0.53989817
72	TEC	0.53523722
73	CHEK2	0.48838399
74	TGFBR1	0.48516547
75	SGK1	0.48125422
76	STK39	0.47032510
77	FRK	0.46516498
78	MKNK2	0.44367195
79	ERBB3	0.44234291
80	STK11	0.42531929
81	RPS6KB1	0.40927622
82	MAPKAPK3	0.37463878
83	PRKCQ	0.37428020
84	ADRBK2	0.36617687
85	INSRR	0.35543333
86	OXSR1	0.35160901
87	ABL2	0.35015753
88	CSNK1D	0.34769185
89	MINK1	0.32681875
90	PLK1	0.31409103
91	GSK3A	0.31365319
92	EPHB2	0.31312228
93	CAMK2D	0.30856707
94	ABL1	0.30751125
95	ATR	0.29971835
96	PAK4	0.28670131
97	CSNK1A1	0.27127919
98	BRD4	0.25864473
99	TIE1	0.25462380
100	DAPK3	0.25288520

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	4.69759102
2	One carbon pool by folate_Homo sapiens_hsa00670	2.89222777
3	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.77020781
4	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.61271542
5	Protein export_Homo sapiens_hsa03060	2.44260108
6	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.36276318
7	RNA polymerase_Homo sapiens_hsa03020	2.35044419
8	Oxidative phosphorylation_Homo sapiens_hsa00190	2.33079167
9	Propanoate metabolism_Homo sapiens_hsa00640	2.27426935
10	Nitrogen metabolism_Homo sapiens_hsa00910	2.06704199
11	Homologous recombination_Homo sapiens_hsa03440	2.06247086
12	Cysteine and methionine metabolism_Homo sapiens_hsa00270	2.05089395
13	Non-homologous end-joining_Homo sapiens_hsa03450	1.95162172
14	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.89919997
15	Nicotine addiction_Homo sapiens_hsa05033	1.88774511
16	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.87951871
17	Basal transcription factors_Homo sapiens_hsa03022	1.77139567
18	Mismatch repair_Homo sapiens_hsa03430	1.75537922
19	Parkinsons disease_Homo sapiens_hsa05012	1.74381616
20	RNA degradation_Homo sapiens_hsa03018	1.73672902
21	Fanconi anemia pathway_Homo sapiens_hsa03460	1.70626165
22	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.64135716
23	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.52059001
24	Phototransduction_Homo sapiens_hsa04744	1.50014495
25	Huntingtons disease_Homo sapiens_hsa05016	1.44551241
26	Butanoate metabolism_Homo sapiens_hsa00650	1.39237517
27	Taste transduction_Homo sapiens_hsa04742	1.37402316
28	Collecting duct acid secretion_Homo sapiens_hsa04966	1.34474303
29	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.33793282
30	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.31040599
31	ABC transporters_Homo sapiens_hsa02010	1.30859414
32	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.30654298
33	Base excision repair_Homo sapiens_hsa03410	1.29332790
34	Glutamatergic synapse_Homo sapiens_hsa04724	1.26601661
35	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.22362408
36	Arginine biosynthesis_Homo sapiens_hsa00220	1.22242802
37	Nucleotide excision repair_Homo sapiens_hsa03420	1.21241624
38	RNA transport_Homo sapiens_hsa03013	1.18963695
39	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.17223630
40	Linoleic acid metabolism_Homo sapiens_hsa00591	1.15626358
41	Alzheimers disease_Homo sapiens_hsa05010	1.14564135
42	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.13860396
43	Purine metabolism_Homo sapiens_hsa00230	1.11556193
44	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.08125211
45	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.07590126
46	Spliceosome_Homo sapiens_hsa03040	1.06703302
47	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.06205536
48	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.05499763
49	DNA replication_Homo sapiens_hsa03030	1.05170169
50	Sulfur relay system_Homo sapiens_hsa04122	1.04116805
51	Ether lipid metabolism_Homo sapiens_hsa00565	1.03848061
52	Peroxisome_Homo sapiens_hsa04146	1.03055794
53	Pyrimidine metabolism_Homo sapiens_hsa00240	1.02122194
54	Selenocompound metabolism_Homo sapiens_hsa00450	0.96897762
55	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.93923722
56	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.93478367
57	Folate biosynthesis_Homo sapiens_hsa00790	0.91601651
58	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.89715925
59	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.85895695
60	Carbon metabolism_Homo sapiens_hsa01200	0.82829880
61	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.81412661
62	Sulfur metabolism_Homo sapiens_hsa00920	0.80337715
63	Metabolic pathways_Homo sapiens_hsa01100	0.78356773
64	GABAergic synapse_Homo sapiens_hsa04727	0.76221070
65	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.74824576
66	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.74178145
67	Morphine addiction_Homo sapiens_hsa05032	0.74099889
68	Asthma_Homo sapiens_hsa05310	0.73092850
69	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.70867613
70	Regulation of autophagy_Homo sapiens_hsa04140	0.70721988
71	Fat digestion and absorption_Homo sapiens_hsa04975	0.70027848
72	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.68210842
73	Pyruvate metabolism_Homo sapiens_hsa00620	0.64841516
74	Steroid biosynthesis_Homo sapiens_hsa00100	0.64449437
75	Serotonergic synapse_Homo sapiens_hsa04726	0.60288228
76	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.59876429
77	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.56861666
78	Tryptophan metabolism_Homo sapiens_hsa00380	0.54748508
79	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.52952845
80	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.51964649
81	Ribosome_Homo sapiens_hsa03010	0.51466011
82	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.51330170
83	Retinol metabolism_Homo sapiens_hsa00830	0.49497494
84	Olfactory transduction_Homo sapiens_hsa04740	0.48106234
85	Glutathione metabolism_Homo sapiens_hsa00480	0.48057246
86	Fatty acid elongation_Homo sapiens_hsa00062	0.47494718
87	Calcium signaling pathway_Homo sapiens_hsa04020	0.44892060
88	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.43538107
89	Alcoholism_Homo sapiens_hsa05034	0.41064387
90	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.40396764
91	Type I diabetes mellitus_Homo sapiens_hsa04940	0.38758423
92	Circadian entrainment_Homo sapiens_hsa04713	0.36656902
93	Primary immunodeficiency_Homo sapiens_hsa05340	0.35086028
94	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.34127828
95	Galactose metabolism_Homo sapiens_hsa00052	0.32641278
96	Caffeine metabolism_Homo sapiens_hsa00232	0.32464606
97	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.30249532
98	Chemical carcinogenesis_Homo sapiens_hsa05204	0.26363873
99	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.26277781
100	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.25740739

GAPDHP55

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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