GAPDHP58

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.06536426
2proteasome assembly (GO:0043248)5.70578291
3establishment of protein localization to mitochondrial membrane (GO:0090151)4.63114777
4cullin deneddylation (GO:0010388)4.61935939
5water-soluble vitamin biosynthetic process (GO:0042364)4.59894950
6mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.55073262
7regulation of cellular amino acid metabolic process (GO:0006521)4.54274483
8negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.44527944
9protein deneddylation (GO:0000338)4.42881356
10ATP synthesis coupled proton transport (GO:0015986)4.41977143
11energy coupled proton transport, down electrochemical gradient (GO:0015985)4.41977143
12maturation of 5.8S rRNA (GO:0000460)4.41191442
13DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.41099597
14signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)4.30594999
15signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)4.30594999
16signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)4.30594999
17signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)4.29121419
18intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)4.29121419
19chaperone-mediated protein transport (GO:0072321)4.26562635
20GTP biosynthetic process (GO:0006183)4.11740772
21positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.08760537
22signal transduction involved in DNA damage checkpoint (GO:0072422)4.08255547
23signal transduction involved in DNA integrity checkpoint (GO:0072401)4.08255547
24mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.02352216
25mitochondrial respiratory chain complex I assembly (GO:0032981)4.02352216
26NADH dehydrogenase complex assembly (GO:0010257)4.02352216
27signal transduction involved in cell cycle checkpoint (GO:0072395)4.01580104
28negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.99350288
29negative regulation of ligase activity (GO:0051352)3.99350288
30regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.96798455
31rRNA modification (GO:0000154)3.96013986
32regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.89518296
33cytidine metabolic process (GO:0046087)3.85965551
34cytidine catabolic process (GO:0006216)3.85965551
35cytidine deamination (GO:0009972)3.85965551
36protein complex biogenesis (GO:0070271)3.85692451
37mitochondrial respiratory chain complex assembly (GO:0033108)3.72148442
38regulation of response to tumor cell (GO:0002834)3.67301374
39positive regulation of response to tumor cell (GO:0002836)3.67301374
40positive regulation of immune response to tumor cell (GO:0002839)3.67301374
41regulation of immune response to tumor cell (GO:0002837)3.67301374
42anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.66563971
43UTP biosynthetic process (GO:0006228)3.59612693
44protein neddylation (GO:0045116)3.58538727
45termination of RNA polymerase III transcription (GO:0006386)3.55738193
46transcription elongation from RNA polymerase III promoter (GO:0006385)3.55738193
47antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.49336052
48rRNA methylation (GO:0031167)3.45956390
49respiratory chain complex IV assembly (GO:0008535)3.45317254
50positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.41453286
51UTP metabolic process (GO:0046051)3.41448645
52positive regulation of cell cycle arrest (GO:0071158)3.38554700
53ribosome assembly (GO:0042255)3.38395865
54guanosine-containing compound biosynthetic process (GO:1901070)3.38239113
55tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.34885186
56RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.34885186
57nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.30990804
58pseudouridine synthesis (GO:0001522)3.30902131
59peptidyl-histidine modification (GO:0018202)3.30483482
60regulation of cellular amine metabolic process (GO:0033238)3.29847086
61positive regulation of ligase activity (GO:0051351)3.28742463
62exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.25824712
63pyrimidine ribonucleoside catabolic process (GO:0046133)3.25206353
64antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.20282117
65DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.19218053
66DNA catabolic process, exonucleolytic (GO:0000738)3.14712085
67protein K6-linked ubiquitination (GO:0085020)3.14328711
68DNA double-strand break processing (GO:0000729)3.09295154
69mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.05127314
70purine nucleoside triphosphate biosynthetic process (GO:0009145)3.02356221
71CTP biosynthetic process (GO:0006241)3.01013676
72CTP metabolic process (GO:0046036)3.01013676
73respiratory electron transport chain (GO:0022904)3.00467317
74electron transport chain (GO:0022900)2.99430129
75negative regulation of mast cell activation (GO:0033004)2.98554916
76protein targeting to mitochondrion (GO:0006626)2.95548796
77purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.95127238
78regulation of ubiquitin-protein transferase activity (GO:0051438)2.92970406
79platelet dense granule organization (GO:0060155)2.92632567
80transcription elongation from RNA polymerase I promoter (GO:0006362)2.92106093
81termination of RNA polymerase I transcription (GO:0006363)2.90467831
82regulation of chronic inflammatory response (GO:0002676)2.87895661
83tRNA processing (GO:0008033)2.85828320
84regulation of ligase activity (GO:0051340)2.84425822
85negative regulation of protein ubiquitination (GO:0031397)2.82910410
86tRNA aminoacylation (GO:0043039)2.82455087
87amino acid activation (GO:0043038)2.82455087
88cytochrome complex assembly (GO:0017004)2.80358850
89tRNA metabolic process (GO:0006399)2.80011466
90L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.79763381
91regulation of cell cycle arrest (GO:0071156)2.79687081
92antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.79538001
93tRNA aminoacylation for protein translation (GO:0006418)2.78095577
94protein peptidyl-prolyl isomerization (GO:0000413)2.76920204
95pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.75325604
96negative regulation of G1/S transition of mitotic cell cycle (GO:2000134)2.74760454
97negative regulation of cell cycle G1/S phase transition (GO:1902807)2.74760454
98mitochondrial RNA metabolic process (GO:0000959)2.74025383
99protein localization to mitochondrion (GO:0070585)2.73255999
100GMP metabolic process (GO:0046037)2.73078055

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.43114188
2GABP_17652178_ChIP-ChIP_JURKAT_Human5.01598530
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.90119874
4EST1_17652178_ChIP-ChIP_JURKAT_Human4.25994188
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.71306559
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.59824110
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.21282960
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.12419429
9ELF1_17652178_ChIP-ChIP_JURKAT_Human3.00147050
10VDR_23849224_ChIP-Seq_CD4+_Human2.85453291
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.84072731
12CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.80055211
13ELK1_19687146_ChIP-ChIP_HELA_Human2.67851747
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.41657992
15FOXP3_21729870_ChIP-Seq_TREG_Human2.33897642
16MYC_18555785_ChIP-Seq_MESCs_Mouse2.23240653
17BP1_19119308_ChIP-ChIP_Hs578T_Human2.22752458
18E2F4_17652178_ChIP-ChIP_JURKAT_Human2.21165001
19SRF_21415370_ChIP-Seq_HL-1_Mouse2.20747463
20ZNF274_21170338_ChIP-Seq_K562_Hela2.13168202
21PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.11401647
22YY1_21170310_ChIP-Seq_MESCs_Mouse2.08084131
23VDR_22108803_ChIP-Seq_LS180_Human1.89131228
24NOTCH1_21737748_ChIP-Seq_TLL_Human1.87610420
25MYC_18358816_ChIP-ChIP_MESCs_Mouse1.84497868
26FLI1_27457419_Chip-Seq_LIVER_Mouse1.83640603
27DCP1A_22483619_ChIP-Seq_HELA_Human1.82469658
28CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.77624180
29HOXB4_20404135_ChIP-ChIP_EML_Mouse1.77366841
30EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.74720672
31FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.73126400
32PADI4_21655091_ChIP-ChIP_MCF-7_Human1.70822686
33MYC_19030024_ChIP-ChIP_MESCs_Mouse1.69733990
34MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.67668699
35IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.59922178
36CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.55427635
37THAP11_20581084_ChIP-Seq_MESCs_Mouse1.55320575
38GABP_19822575_ChIP-Seq_HepG2_Human1.54531862
39EWS_26573619_Chip-Seq_HEK293_Human1.53824930
40MYC_18940864_ChIP-ChIP_HL60_Human1.53375258
41PCGF2_27294783_Chip-Seq_ESCs_Mouse1.42306327
42IGF1R_20145208_ChIP-Seq_DFB_Human1.41770940
43E2F1_18555785_ChIP-Seq_MESCs_Mouse1.40507032
44PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31081555
45EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.30895059
46TTF2_22483619_ChIP-Seq_HELA_Human1.29918842
47ELK1_22589737_ChIP-Seq_MCF10A_Human1.29640965
48TP53_22573176_ChIP-Seq_HFKS_Human1.29189660
49CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.28861867
50IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.28402999
51TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28245792
52FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.27218211
53HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.26615039
54PCGF2_27294783_Chip-Seq_NPCs_Mouse1.24948122
55FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.21733022
56GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.18395551
57FOXA1_27270436_Chip-Seq_PROSTATE_Human1.11897302
58FOXA1_25329375_ChIP-Seq_VCAP_Human1.11897302
59SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.11217429
60ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.10848460
61FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.09939759
62HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.09313835
63MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.08349149
64YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.08286792
65AR_20517297_ChIP-Seq_VCAP_Human1.06799603
66SOX2_19829295_ChIP-Seq_ESCs_Human1.04480710
67NANOG_19829295_ChIP-Seq_ESCs_Human1.04480710
68CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.01870247
69GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01194030
70MYC_19079543_ChIP-ChIP_MESCs_Mouse0.99872944
71GATA3_26560356_Chip-Seq_TH2_Human0.99074529
72SUZ12_27294783_Chip-Seq_NPCs_Mouse0.98912677
73SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.98115158
74PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.97775912
75NFE2_27457419_Chip-Seq_LIVER_Mouse0.97587879
76NELFA_20434984_ChIP-Seq_ESCs_Mouse0.96735186
77P300_19829295_ChIP-Seq_ESCs_Human0.95527554
78STAT4_19710469_ChIP-ChIP_TH1__Mouse0.94549635
79NCOR_22424771_ChIP-Seq_293T_Human0.94219422
80POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.92723247
81PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.91035646
82IRF1_19129219_ChIP-ChIP_H3396_Human0.90388995
83GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.89903877
84FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89788840
85XRN2_22483619_ChIP-Seq_HELA_Human0.88832871
86LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86290099
87EGR1_23403033_ChIP-Seq_LIVER_Mouse0.84585557
88ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.83392599
89FUS_26573619_Chip-Seq_HEK293_Human0.82893281
90HOXB7_26014856_ChIP-Seq_BT474_Human0.82658744
91FOXH1_21741376_ChIP-Seq_EPCs_Human0.81862436
92FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.81739307
93EZH2_27294783_Chip-Seq_NPCs_Mouse0.79266882
94TAF2_19829295_ChIP-Seq_ESCs_Human0.76869457
95ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.76793782
96GATA3_21878914_ChIP-Seq_MCF-7_Human0.75736522
97AUTS2_25519132_ChIP-Seq_293T-REX_Human0.75587233
98KDM5A_27292631_Chip-Seq_BREAST_Human0.74780356
99E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.74168516
100MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.74117275

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology3.23185487
2MP0002138_abnormal_hepatobiliary_system2.86896148
3MP0005084_abnormal_gallbladder_morpholo2.66852315
4MP0005671_abnormal_response_to2.60527307
5MP0002163_abnormal_gland_morphology2.59372899
6MP0001835_abnormal_antigen_presentation2.54899125
7MP0001873_stomach_inflammation2.52159584
8MP0008058_abnormal_DNA_repair2.37306266
9MP0008872_abnormal_physiological_respon2.37115788
10MP0000685_abnormal_immune_system2.35486024
11MP0003786_premature_aging2.28370565
12MP0003693_abnormal_embryo_hatching2.25707638
13MP0005379_endocrine/exocrine_gland_phen2.18403736
14MP0003186_abnormal_redox_activity2.18171427
15MP0008007_abnormal_cellular_replicative2.17388785
16MP0008877_abnormal_DNA_methylation2.14315437
17MP0006036_abnormal_mitochondrial_physio2.10835328
18MP0003806_abnormal_nucleotide_metabolis1.99774735
19MP0005167_abnormal_blood-brain_barrier1.96080648
20MP0002148_abnormal_hypersensitivity_rea1.94813178
21MP0008875_abnormal_xenobiotic_pharmacok1.94593551
22MP0003950_abnormal_plasma_membrane1.86454407
23MP0004145_abnormal_muscle_electrophysio1.81284599
24MP0009333_abnormal_splenocyte_physiolog1.81245558
25MP0001790_abnormal_immune_system1.78842893
26MP0005387_immune_system_phenotype1.78842893
27MP0003718_maternal_effect1.78401738
28MP0009785_altered_susceptibility_to1.75240839
29MP0002166_altered_tumor_susceptibility1.72023907
30MP0006035_abnormal_mitochondrial_morpho1.71437470
31MP0003646_muscle_fatigue1.71378001
32MP0002876_abnormal_thyroid_physiology1.69384112
33MP0005645_abnormal_hypothalamus_physiol1.68712096
34MP0003011_delayed_dark_adaptation1.65440770
35MP0008775_abnormal_heart_ventricle1.62422300
36MP0002837_dystrophic_cardiac_calcinosis1.61607040
37MP0001529_abnormal_vocalization1.54495971
38MP0010094_abnormal_chromosome_stability1.53680089
39MP0004957_abnormal_blastocyst_morpholog1.52155929
40MP0002006_tumorigenesis1.43410709
41MP0001800_abnormal_humoral_immune1.35765035
42MP0004885_abnormal_endolymph1.34006549
43MP0005551_abnormal_eye_electrophysiolog1.29469789
44MP0005075_abnormal_melanosome_morpholog1.29161229
45MP0004147_increased_porphyrin_level1.28056818
46MP0006072_abnormal_retinal_apoptosis1.19904714
47MP0009764_decreased_sensitivity_to1.19322928
48MP0004142_abnormal_muscle_tone1.18831103
49MP0000372_irregular_coat_pigmentation1.18431513
50MP0006276_abnormal_autonomic_nervous1.18374549
51MP0001348_abnormal_lacrimal_gland1.17909591
52MP0001968_abnormal_touch/_nociception1.17530654
53MP0003195_calcinosis1.15947965
54MP0002736_abnormal_nociception_after1.14141546
55MP0006082_CNS_inflammation1.13948505
56MP0001501_abnormal_sleep_pattern1.10208117
57MP0004782_abnormal_surfactant_physiolog1.09608172
58MP0003866_abnormal_defecation1.06549640
59MP0005670_abnormal_white_adipose1.02983354
60MP0005332_abnormal_amino_acid1.01701351
61MP0005000_abnormal_immune_tolerance0.95970582
62MP0002723_abnormal_immune_serum0.91081629
63MP0000613_abnormal_salivary_gland0.90119060
64MP0004215_abnormal_myocardial_fiber0.87814309
65MP0002254_reproductive_system_inflammat0.87666414
66MP0003567_abnormal_fetal_cardiomyocyte0.87426440
67MP0000358_abnormal_cell_content/0.87288698
68MP0002693_abnormal_pancreas_physiology0.86053586
69MP0005389_reproductive_system_phenotype0.85838637
70MP0009745_abnormal_behavioral_response0.85520106
71MP0002751_abnormal_autonomic_nervous0.84320283
72MP0002452_abnormal_antigen_presenting0.83935647
73MP0001905_abnormal_dopamine_level0.83845067
74MP0010386_abnormal_urinary_bladder0.83239307
75MP0001984_abnormal_olfaction0.82315380
76MP0001502_abnormal_circadian_rhythm0.81679661
77MP0002420_abnormal_adaptive_immunity0.80800306
78MP0001764_abnormal_homeostasis0.80594819
79MP0001819_abnormal_immune_cell0.80152505
80MP0005253_abnormal_eye_physiology0.78755348
81MP0008873_increased_physiological_sensi0.78628829
82MP0005408_hypopigmentation0.78416452
83MP0001440_abnormal_grooming_behavior0.77261391
84MP0005646_abnormal_pituitary_gland0.75808369
85MP0000749_muscle_degeneration0.75637911
86MP0001663_abnormal_digestive_system0.74687785
87MP0009046_muscle_twitch0.74672929
88MP0005636_abnormal_mineral_homeostasis0.74301426
89MP0003111_abnormal_nucleus_morphology0.74178927
90MP0001986_abnormal_taste_sensitivity0.73800308
91MP0005365_abnormal_bile_salt0.73778390
92MP0005330_cardiomyopathy0.72924776
93MP0004019_abnormal_vitamin_homeostasis0.71372295
94MP0001881_abnormal_mammary_gland0.71314992
95MP0003077_abnormal_cell_cycle0.71094991
96MP0005410_abnormal_fertilization0.70966719
97MP0002272_abnormal_nervous_system0.70617169
98MP0002938_white_spotting0.70253820
99MP0005319_abnormal_enzyme/_coenzyme0.68956321
100MP0005165_increased_susceptibility_to0.68933282

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.02735857
2Acute encephalopathy (HP:0006846)4.42318638
3Abnormal mitochondria in muscle tissue (HP:0008316)4.30641252
4Mitochondrial inheritance (HP:0001427)4.30427000
5Increased CSF lactate (HP:0002490)4.23800989
6Progressive macrocephaly (HP:0004481)4.09593420
7Hepatocellular necrosis (HP:0001404)4.02439138
8Hepatic necrosis (HP:0002605)3.65951212
9Increased serum lactate (HP:0002151)3.61864885
10Cerebral edema (HP:0002181)3.28819736
11Hypoproteinemia (HP:0003075)3.15830970
123-Methylglutaconic aciduria (HP:0003535)3.07401109
13Stomatitis (HP:0010280)3.03575837
14Optic disc pallor (HP:0000543)3.00757575
15Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.90755716
16Increased serum pyruvate (HP:0003542)2.87671704
17Lactic acidosis (HP:0003128)2.85134739
18Increased hepatocellular lipid droplets (HP:0006565)2.83410852
19Lipid accumulation in hepatocytes (HP:0006561)2.79866015
20Abnormality of alanine metabolism (HP:0010916)2.79215751
21Hyperalaninemia (HP:0003348)2.79215751
22Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.79215751
23Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.78759532
24Respiratory failure (HP:0002878)2.74239634
25Abnormality of glycolysis (HP:0004366)2.72115797
26Abnormality of the anterior horn cell (HP:0006802)2.70246901
27Degeneration of anterior horn cells (HP:0002398)2.70246901
28Methylmalonic acidemia (HP:0002912)2.65529041
29Methylmalonic aciduria (HP:0012120)2.64423393
30Exercise intolerance (HP:0003546)2.64012668
31IgG deficiency (HP:0004315)2.63121546
32Decreased electroretinogram (ERG) amplitude (HP:0000654)2.62150828
33Pancreatic cysts (HP:0001737)2.56489220
34Elevated erythrocyte sedimentation rate (HP:0003565)2.45712653
35Abnormality of the pons (HP:0007361)2.45158317
36Leukodystrophy (HP:0002415)2.44319956
37Abnormality of midbrain morphology (HP:0002418)2.38496992
38Molar tooth sign on MRI (HP:0002419)2.38496992
39Renal Fanconi syndrome (HP:0001994)2.36867159
40Aplasia/hypoplasia of the uterus (HP:0008684)2.36747510
41Type I transferrin isoform profile (HP:0003642)2.36544411
42Oral leukoplakia (HP:0002745)2.35610213
43Meckel diverticulum (HP:0002245)2.34807609
44Lethargy (HP:0001254)2.32304866
45Abnormality of the ileum (HP:0001549)2.31145873
46Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.29780538
47Abnormal protein N-linked glycosylation (HP:0012347)2.29780538
48Abnormal protein glycosylation (HP:0012346)2.29780538
49Abnormal glycosylation (HP:0012345)2.29780538
50CNS demyelination (HP:0007305)2.28982421
51Increased IgM level (HP:0003496)2.28906704
52Abnormality of the labia minora (HP:0012880)2.28801620
53Large for gestational age (HP:0001520)2.28482664
54Colon cancer (HP:0003003)2.27725661
55Congenital, generalized hypertrichosis (HP:0004540)2.22504965
56Exertional dyspnea (HP:0002875)2.22503643
57Abnormality of the renal cortex (HP:0011035)2.21378737
58Congenital stationary night blindness (HP:0007642)2.19660472
59Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.18375555
60Decreased activity of mitochondrial respiratory chain (HP:0008972)2.18375555
61Progressive inability to walk (HP:0002505)2.18365811
62Dyschromatopsia (HP:0007641)2.15560706
63Cerebral hypomyelination (HP:0006808)2.15320094
64Abnormality of methionine metabolism (HP:0010901)2.15104083
65Hypoplasia of the uterus (HP:0000013)2.12902662
66Constricted visual fields (HP:0001133)2.12382023
67Abnormality of aspartate family amino acid metabolism (HP:0010899)2.09119988
68Abolished electroretinogram (ERG) (HP:0000550)2.04892210
69Pancytopenia (HP:0001876)2.04232358
70Hypoplasia of the pons (HP:0012110)1.98712098
71Inability to walk (HP:0002540)1.97812774
72Cerebral hemorrhage (HP:0001342)1.97616941
73Delayed CNS myelination (HP:0002188)1.92214710
74X-linked dominant inheritance (HP:0001423)1.92081544
75Horseshoe kidney (HP:0000085)1.91683250
76Nephronophthisis (HP:0000090)1.87750267
77Increased corneal curvature (HP:0100692)1.87606412
78Keratoconus (HP:0000563)1.87606412
79Polyuria (HP:0000103)1.85738083
80Abnormality of serum amino acid levels (HP:0003112)1.82830112
81Abnormality of the renal medulla (HP:0100957)1.82783766
82Pendular nystagmus (HP:0012043)1.82473180
83Rough bone trabeculation (HP:0100670)1.80273715
84Aplasia/Hypoplasia involving the musculature (HP:0001460)1.80104858
85True hermaphroditism (HP:0010459)1.80005774
86Oligodactyly (hands) (HP:0001180)1.79755652
87Intestinal atresia (HP:0011100)1.79641102
88Neutropenia (HP:0001875)1.78868334
89Duodenal stenosis (HP:0100867)1.75751578
90Small intestinal stenosis (HP:0012848)1.75751578
91Alkalosis (HP:0001948)1.66745172
92Chronic diarrhea (HP:0002028)1.66551775
93Abnormality of T cell physiology (HP:0011840)1.66488627
94Glycosuria (HP:0003076)1.66048416
95Abnormality of urine glucose concentration (HP:0011016)1.66048416
96Reduced antithrombin III activity (HP:0001976)1.62866257
97Abnormality of the vitamin B12 metabolism (HP:0004341)1.62706652
98Duplicated collecting system (HP:0000081)1.62136238
99CNS hypomyelination (HP:0003429)1.62092259
100Hypokalemic alkalosis (HP:0001949)1.62039726

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.91474212
2TIE13.70905378
3NUAK13.35477367
4TSSK63.34554799
5MST43.08683345
6BUB13.02751908
7EIF2AK32.85450975
8EIF2AK12.30124674
9GRK12.27364383
10VRK12.26360343
11SRPK12.21417151
12TAF12.18656119
13TRIM282.06529076
14TLK11.98497148
15PLK31.91849978
16MAP2K61.90925913
17ZAK1.87606199
18NEK11.83043327
19NME11.75177073
20ADRBK21.70718317
21PDK21.62258521
22TXK1.61507521
23BCKDK1.54852880
24PBK1.50145495
25DAPK11.44586376
26MAP3K121.39717366
27MAP4K21.33569937
28CSNK1G31.31758316
29MAPKAPK31.21739548
30TEC1.20887496
31CSNK1A1L1.19753879
32CSNK1G11.18707683
33BCR1.17828991
34STK161.13133481
35WNK41.13038961
36PLK21.08655141
37FES1.08634257
38EIF2AK21.06349659
39CSNK1G21.05723019
40STK391.03123725
41OXSR11.02551762
42PINK10.99261063
43DYRK20.98234387
44BMPR1B0.91640804
45GRK50.89202081
46TAOK30.87460759
47LIMK10.84478574
48FRK0.84164254
49IKBKB0.83215483
50INSRR0.82735425
51PASK0.81172930
52MYLK0.80332138
53PHKG10.78474354
54PHKG20.78474354
55KIT0.77549091
56FER0.72072839
57PIK3CG0.70907796
58TGFBR10.68099607
59CCNB10.67533434
60PTK2B0.64169697
61MKNK20.63657216
62MAPKAPK50.61540448
63MKNK10.54134452
64PRKCI0.49497969
65WNK30.49198845
66CDK80.48729335
67ATR0.48061639
68SMG10.46051457
69NME20.45158329
70PRKCQ0.44989409
71PRKCG0.44575650
72PLK10.44463904
73BRSK10.43943906
74TGFBR20.43687979
75SIK30.42734863
76PRKCE0.41616411
77ALK0.40430355
78STK38L0.39344109
79TTK0.38057647
80DAPK30.37939068
81NLK0.37441183
82ILK0.35751789
83AURKB0.35540740
84CSNK2A10.34352543
85MAP4K10.33620360
86ITK0.33332906
87CSNK1A10.32692989
88PAK30.29994902
89MAPK130.29638067
90PAK40.29524082
91RPS6KA50.25992200
92PIK3CA0.25474405
93CAMK2A0.25172790
94IGF1R0.24701214
95WEE10.24628930
96DAPK20.24622774
97CASK0.23742261
98NEK20.23389633
99TNIK0.22960684
100PRKG10.22506924

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.84080404
2Protein export_Homo sapiens_hsa030603.38780492
3Oxidative phosphorylation_Homo sapiens_hsa001902.99949883
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.88781223
5RNA polymerase_Homo sapiens_hsa030202.85399991
6Parkinsons disease_Homo sapiens_hsa050122.44401606
7One carbon pool by folate_Homo sapiens_hsa006701.92736194
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.90040522
9Mismatch repair_Homo sapiens_hsa034301.80950560
10Propanoate metabolism_Homo sapiens_hsa006401.77191555
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.73354142
12Huntingtons disease_Homo sapiens_hsa050161.66421579
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.66057899
14Homologous recombination_Homo sapiens_hsa034401.58159311
15RNA degradation_Homo sapiens_hsa030181.57546522
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.52044970
17Alzheimers disease_Homo sapiens_hsa050101.51935979
18Pyrimidine metabolism_Homo sapiens_hsa002401.51896746
19Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.50566153
20Sulfur metabolism_Homo sapiens_hsa009201.49797024
21Ribosome_Homo sapiens_hsa030101.47535962
22Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.46005628
23RNA transport_Homo sapiens_hsa030131.43913601
24Allograft rejection_Homo sapiens_hsa053301.41707240
25Basal transcription factors_Homo sapiens_hsa030221.39946801
26Nitrogen metabolism_Homo sapiens_hsa009101.39789221
27DNA replication_Homo sapiens_hsa030301.36550970
28Pyruvate metabolism_Homo sapiens_hsa006201.36336587
29Fatty acid elongation_Homo sapiens_hsa000621.35452102
30Intestinal immune network for IgA production_Homo sapiens_hsa046721.32603454
31Nucleotide excision repair_Homo sapiens_hsa034201.31528890
32Primary immunodeficiency_Homo sapiens_hsa053401.31502061
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.28432115
34Non-homologous end-joining_Homo sapiens_hsa034501.28389324
35Autoimmune thyroid disease_Homo sapiens_hsa053201.25285318
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.24198360
37Purine metabolism_Homo sapiens_hsa002301.23366248
38Collecting duct acid secretion_Homo sapiens_hsa049661.23090018
39Spliceosome_Homo sapiens_hsa030401.20256758
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.15821969
41Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.15753558
42Asthma_Homo sapiens_hsa053101.14894863
43Fanconi anemia pathway_Homo sapiens_hsa034601.14302485
44Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.09682037
45Base excision repair_Homo sapiens_hsa034101.06699884
46Graft-versus-host disease_Homo sapiens_hsa053321.06515748
47Type I diabetes mellitus_Homo sapiens_hsa049401.05395475
48Antigen processing and presentation_Homo sapiens_hsa046121.04910933
49Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.03678447
50Tryptophan metabolism_Homo sapiens_hsa003801.01332250
51Steroid biosynthesis_Homo sapiens_hsa001000.97028525
52Vitamin B6 metabolism_Homo sapiens_hsa007500.96874309
53Glutathione metabolism_Homo sapiens_hsa004800.96870798
54Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.96677549
55Linoleic acid metabolism_Homo sapiens_hsa005910.94767993
56Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.94130453
57alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.93361063
58Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.93340515
59Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.90992780
60beta-Alanine metabolism_Homo sapiens_hsa004100.87654810
61Phototransduction_Homo sapiens_hsa047440.87412610
62Peroxisome_Homo sapiens_hsa041460.81541687
63Cardiac muscle contraction_Homo sapiens_hsa042600.81289094
642-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.77943422
65Carbon metabolism_Homo sapiens_hsa012000.76811097
66Rheumatoid arthritis_Homo sapiens_hsa053230.75385004
67Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.75201119
68Metabolic pathways_Homo sapiens_hsa011000.71905987
69Butanoate metabolism_Homo sapiens_hsa006500.67490936
70SNARE interactions in vesicular transport_Homo sapiens_hsa041300.66814798
71Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.65585214
72Cyanoamino acid metabolism_Homo sapiens_hsa004600.64772701
73N-Glycan biosynthesis_Homo sapiens_hsa005100.63541335
74Folate biosynthesis_Homo sapiens_hsa007900.63134422
75Selenocompound metabolism_Homo sapiens_hsa004500.62121832
76Ether lipid metabolism_Homo sapiens_hsa005650.59791049
77Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.59583007
78Biosynthesis of amino acids_Homo sapiens_hsa012300.57839041
79Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.53423006
80Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.52377436
81Hematopoietic cell lineage_Homo sapiens_hsa046400.52233746
82Sulfur relay system_Homo sapiens_hsa041220.51370046
83Chemical carcinogenesis_Homo sapiens_hsa052040.47983701
84Caffeine metabolism_Homo sapiens_hsa002320.46644187
85Regulation of autophagy_Homo sapiens_hsa041400.46456431
86Arachidonic acid metabolism_Homo sapiens_hsa005900.44975756
87Pentose and glucuronate interconversions_Homo sapiens_hsa000400.43308388
88Epstein-Barr virus infection_Homo sapiens_hsa051690.39177503
89Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.39138696
90Vibrio cholerae infection_Homo sapiens_hsa051100.37775592
91Fatty acid degradation_Homo sapiens_hsa000710.36850647
92Arginine and proline metabolism_Homo sapiens_hsa003300.36264246
93Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.36203254
94p53 signaling pathway_Homo sapiens_hsa041150.36027408
95Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.35337000
96Fatty acid metabolism_Homo sapiens_hsa012120.35041864
97Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.34537153
98Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.32153505
99Fat digestion and absorption_Homo sapiens_hsa049750.31850332
100Steroid hormone biosynthesis_Homo sapiens_hsa001400.27108888

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »