ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	eosinophil migration (GO:0072677)	9.44249583
2	negative regulation of peptidyl-threonine phosphorylation (GO:0010801)	9.38098959
3	regulation of sister chromatid cohesion (GO:0007063)	9.23953292
4	regulation of mononuclear cell migration (GO:0071675)	9.21222286
5	ribosomal small subunit assembly (GO:0000028)	8.61204203
6	branch elongation of an epithelium (GO:0060602)	8.33912674
7	fucose catabolic process (GO:0019317)	8.00879777
8	L-fucose metabolic process (GO:0042354)	8.00879777
9	L-fucose catabolic process (GO:0042355)	8.00879777
10	negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)	7.96695694
11	negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)	7.80827447
12	vesicle fusion (GO:0006906)	7.65182886
13	positive regulation of chromosome segregation (GO:0051984)	7.60745761
14	coenzyme A biosynthetic process (GO:0015937)	7.47863843
15	peptidyl-lysine dimethylation (GO:0018027)	7.45281428
16	autophagic vacuole fusion (GO:0000046)	6.86359359
17	localization within membrane (GO:0051668)	6.62900376
18	macrophage chemotaxis (GO:0048246)	6.50144798
19	organ growth (GO:0035265)	6.37066457
20	axis elongation (GO:0003401)	6.14536754
21	positive regulation of calcium ion import (GO:0090280)	6.12026742
22	establishment of mitotic spindle orientation (GO:0000132)	5.88487246
23	negative regulation of GTP catabolic process (GO:0033125)	5.87477644
24	negative regulation of GTPase activity (GO:0034260)	5.87477644
25	regulation of beta-amyloid formation (GO:1902003)	5.84396031
26	monocyte chemotaxis (GO:0002548)	5.71915482
27	protein import into peroxisome matrix (GO:0016558)	5.70247130
28	regulation of nitric-oxide synthase biosynthetic process (GO:0051769)	5.68213642
29	regulation of T cell receptor signaling pathway (GO:0050856)	5.62167846
30	organelle membrane fusion (GO:0090174)	5.28267705
31	establishment of mitotic spindle localization (GO:0040001)	5.17041418
32	establishment of spindle orientation (GO:0051294)	5.09594732
33	non-recombinational repair (GO:0000726)	5.04777829
34	double-strand break repair via nonhomologous end joining (GO:0006303)	5.04777829
35	oxidative demethylation (GO:0070989)	4.92460195
36	histone H3-K9 methylation (GO:0051567)	4.87222446
37	acrosome assembly (GO:0001675)	4.85484408
38	seminiferous tubule development (GO:0072520)	4.81084988
39	3-UTR-mediated mRNA stabilization (GO:0070935)	4.80239817
40	detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)	4.78705704
41	negative regulation of circadian rhythm (GO:0042754)	4.65450933
42	purine nucleoside bisphosphate biosynthetic process (GO:0034033)	4.63373741
43	ribonucleoside bisphosphate biosynthetic process (GO:0034030)	4.63373741
44	nucleoside bisphosphate biosynthetic process (GO:0033866)	4.63373741
45	pantothenate metabolic process (GO:0015939)	4.61233231
46	regulation of amyloid precursor protein catabolic process (GO:1902991)	4.59588646
47	positive chemotaxis (GO:0050918)	4.58397455
48	organelle fusion (GO:0048284)	4.55652930
49	regulation of stem cell maintenance (GO:2000036)	4.50934065
50	fucose metabolic process (GO:0006004)	4.41203209
51	regulation of autophagic vacuole assembly (GO:2000785)	4.30890450
52	fucosylation (GO:0036065)	4.29719802
53	coenzyme A metabolic process (GO:0015936)	4.26088690
54	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	4.23589652
55	positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)	4.22220589
56	regulation of fibroblast growth factor receptor signaling pathway (GO:0040036)	4.19912042
57	detection of chemical stimulus involved in sensory perception of taste (GO:0050912)	4.11086317
58	negative regulation of purine nucleotide catabolic process (GO:0033122)	4.02653471
59	histone H3-K9 modification (GO:0061647)	4.01745200
60	regulation of mammary gland epithelial cell proliferation (GO:0033599)	4.00485136
61	protein targeting to lysosome (GO:0006622)	3.99073133
62	establishment of protein localization to vacuole (GO:0072666)	3.99073133
63	protein targeting to vacuole (GO:0006623)	3.99073133
64	negative regulation of nucleotide catabolic process (GO:0030812)	3.93536886
65	regulation of antigen receptor-mediated signaling pathway (GO:0050854)	3.91082332
66	single-organism membrane fusion (GO:0044801)	3.77663456
67	establishment of spindle localization (GO:0051293)	3.77590721
68	membrane budding (GO:0006900)	3.75416812
69	negative regulation of macroautophagy (GO:0016242)	3.74729026
70	regulation of cellular amide metabolic process (GO:0034248)	3.69693211
71	negative regulation of nucleoside metabolic process (GO:0045978)	3.67137861
72	regulation of peptidyl-threonine phosphorylation (GO:0010799)	3.66590507
73	protein targeting to peroxisome (GO:0006625)	3.66241245
74	establishment of protein localization to peroxisome (GO:0072663)	3.66241245
75	protein localization to peroxisome (GO:0072662)	3.66241245
76	regulation of calcium ion import (GO:0090279)	3.59216620
77	regulation of vacuole organization (GO:0044088)	3.58444151
78	imidazole-containing compound metabolic process (GO:0052803)	3.55938430
79	preassembly of GPI anchor in ER membrane (GO:0016254)	3.49842032
80	sodium-independent organic anion transport (GO:0043252)	3.44692872
81	ER to Golgi vesicle-mediated transport (GO:0006888)	3.39579923
82	metallo-sulfur cluster assembly (GO:0031163)	3.38923522
83	iron-sulfur cluster assembly (GO:0016226)	3.38923522
84	peroxisomal transport (GO:0043574)	3.38565852
85	negative regulation of dendrite morphogenesis (GO:0050774)	3.38289259
86	DNA demethylation (GO:0080111)	3.38093319
87	vesicle targeting (GO:0006903)	3.38057939
88	DNA integration (GO:0015074)	3.37461036
89	peptidyl-lysine trimethylation (GO:0018023)	3.32245742
90	regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:2	3.29595755
91	proteasome assembly (GO:0043248)	3.20878716
92	negative regulation of ERK1 and ERK2 cascade (GO:0070373)	3.19571323
93	protein prenylation (GO:0018342)	12.7221036
94	prenylation (GO:0097354)	12.7221036
95	negative regulation of Ras GTPase activity (GO:0034261)	12.3277031
96	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	11.8491797
97	positive regulation of mitotic sister chromatid separation (GO:1901970)	11.8491797
98	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	11.8491797
99	eosinophil chemotaxis (GO:0048245)	10.4382367
100	negative regulation of T cell receptor signaling pathway (GO:0050860)	10.1250386

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	9.41349017
2	VDR_22108803_ChIP-Seq_LS180_Human	6.44871357
3	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	4.51667535
4	NOTCH1_21737748_ChIP-Seq_TLL_Human	4.45347762
5	AR_21572438_ChIP-Seq_LNCaP_Human	3.39618428
6	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.78932417
7	SRY_22984422_ChIP-ChIP_TESTIS_Rat	2.78894822
8	ZNF263_19887448_ChIP-Seq_K562_Human	2.49553158
9	ZIC3_20872845_ChIP-ChIP_MESCs_Mouse	2.49131853
10	YY1_21170310_ChIP-Seq_MESCs_Mouse	2.48144586
11	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.34518183
12	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.32524343
13	GATA1_22025678_ChIP-Seq_K562_Human	10.6973469
14	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.88285769
15	RXR_22108803_ChIP-Seq_LS180_Human	1.86788592
16	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.82740913
17	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.79306708
18	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.79306708
19	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.69316255
20	BCAT_22108803_ChIP-Seq_LS180_Human	1.61678392
21	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.60601116
22	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.59724743
23	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.54034091
24	EZH2_22144423_ChIP-Seq_EOC_Human	1.45772473
25	IRF1_19129219_ChIP-ChIP_H3396_Human	1.41750981
26	TAF15_26573619_Chip-Seq_HEK293_Human	1.41644837
27	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.39600720
28	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.36632757
29	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.35297059
30	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.35297059
31	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.35297059
32	TP53_16413492_ChIP-PET_HCT116_Human	1.34354764
33	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.33524257
34	GBX2_23144817_ChIP-Seq_PC3_Human	1.28736031
35	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.27142298
36	GATA3_26560356_Chip-Seq_TH1_Human	1.20831909
37	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.17560736
38	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.14318492
39	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.13762752
40	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.12235552
41	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.10901010
42	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.07944161
43	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.07310647
44	ZNF274_21170338_ChIP-Seq_K562_Hela	1.02011588
45	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.00701184
46	ETS1_20019798_ChIP-Seq_JURKAT_Human	0.99253681
47	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	0.90880563
48	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.90710733
49	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.90252397
50	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.88723104
51	CTCF_21964334_Chip-Seq_Bcells_Human	0.86813853
52	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.86361952
53	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.85387211
54	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	0.83752449
55	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.81966079
56	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	0.80904333
57	TP53_22573176_ChIP-Seq_HFKS_Human	0.80419397
58	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.77573755
59	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	0.75302530
60	EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	0.73802410
61	SOX3_22085726_ChIP-Seq_MUSCLE_Mouse	0.72856563
62	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.72514070
63	RING1B_27294783_Chip-Seq_NPCs_Mouse	0.72446679
64	STAT1_20625510_ChIP-Seq_HELA_Human	0.71613953
65	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	0.71533494
66	TBX3_20139965_ChIP-Seq_ESCs_Mouse	0.71064522
67	TBX3_20139965_ChIP-Seq_MESCs_Mouse	0.70565640
68	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.69850249
69	CTNNB1_20460455_ChIP-Seq_HCT116_Human	0.68994025
70	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.68870899
71	GATA3_21867929_ChIP-Seq_TH1_Mouse	0.68565174
72	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.67220560
73	FUS_26573619_Chip-Seq_HEK293_Human	0.66278274
74	SUZ12_27294783_Chip-Seq_ESCs_Mouse	0.64669305
75	CDX2_20551321_ChIP-Seq_CACO-2_Human	0.64614978
76	TCF4_22108803_ChIP-Seq_LS180_Human	0.64065130
77	TRIM28_19339689_ChIP-ChIP_MESCs_Mouse	0.63965700
78	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	0.63546846
79	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.63491427
80	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.63491427
81	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.62730684
82	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.62636119
83	NANOG_20526341_ChIP-Seq_ESCs_Human	0.62449652
84	NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human	0.62421668
85	MYC_18555785_ChIP-Seq_MESCs_Mouse	0.62413645
86	RUNX_20019798_ChIP-Seq_JUKART_Human	0.61999878
87	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.60856828
88	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	0.60514216
89	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.60178632
90	P300_19829295_ChIP-Seq_ESCs_Human	0.59792869
91	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.59764192
92	HTT_18923047_ChIP-ChIP_STHdh_Human	0.59472015
93	SMC3_22415368_ChIP-Seq_MEFs_Mouse	0.59229387
94	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.58907016
95	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.58000736
96	OCT1_27270436_Chip-Seq_PROSTATE_Human	0.54823301
97	NANOG_19829295_ChIP-Seq_ESCs_Human	0.53729425
98	SOX2_19829295_ChIP-Seq_ESCs_Human	0.53729425
99	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.53224951
100	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.52934101

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003303_peritoneal_inflammation	9.55416877
2	MP0006082_CNS_inflammation	5.13823730
3	MP0000467_abnormal_esophagus_morphology	3.18868987
4	MP0001664_abnormal_digestion	3.15149702
5	MP0001663_abnormal_digestive_system	3.14611057
6	MP0001919_abnormal_reproductive_system	2.69446861
7	MP0003115_abnormal_respiratory_system	2.55314407
8	MP0002751_abnormal_autonomic_nervous	2.47948378
9	MP0005381_digestive/alimentary_phenotyp	2.42081934
10	MP0000383_abnormal_hair_follicle	2.30425956
11	MP0002876_abnormal_thyroid_physiology	2.03344957
12	MP0000566_synostosis	13.0735877
13	MP0000534_abnormal_ureter_morphology	1.74496946
14	MP0005166_decreased_susceptibility_to	1.69508294
15	MP0005389_reproductive_system_phenotype	1.68682208
16	MP0001915_intracranial_hemorrhage	1.66503770
17	MP0003937_abnormal_limbs/digits/tail_de	1.58318529
18	MP0010678_abnormal_skin_adnexa	1.48284762
19	MP0001293_anophthalmia	1.38824497
20	MP0000428_abnormal_craniofacial_morphol	1.38600842
21	MP0001545_abnormal_hematopoietic_system	1.29268954
22	MP0005397_hematopoietic_system_phenotyp	1.29268954
23	MP0003453_abnormal_keratinocyte_physiol	1.26192521
24	MP0001286_abnormal_eye_development	1.18215641
25	MP0005076_abnormal_cell_differentiation	1.13442009
26	MP0003942_abnormal_urinary_system	1.06970251
27	MP0005501_abnormal_skin_physiology	1.02651242
28	MP0000490_abnormal_crypts_of	1.00940307
29	MP0000026_abnormal_inner_ear	0.97407886
30	MP0001963_abnormal_hearing_physiology	0.94044726
31	MP0001764_abnormal_homeostasis	0.91129484
32	MP0002109_abnormal_limb_morphology	0.88943696
33	MP0000858_altered_metastatic_potential	0.85952546
34	MP0000470_abnormal_stomach_morphology	0.83074567
35	MP0003763_abnormal_thymus_physiology	0.81829428
36	MP0002019_abnormal_tumor_incidence	0.79918863
37	MP0003329_amyloid_beta_deposits	0.76216458
38	MP0005197_abnormal_uvea_morphology	0.75793289
39	MP0002184_abnormal_innervation	0.75442173
40	MP0002115_abnormal_skeleton_extremities	0.74162024
41	MP0000358_abnormal_cell_content/	0.64558621
42	MP0003879_abnormal_hair_cell	0.60618950
43	MP0002210_abnormal_sex_determination	0.59000278
44	MP0010155_abnormal_intestine_physiology	0.58977367
45	MP0000477_abnormal_intestine_morphology	0.58583322
46	MP0000432_abnormal_head_morphology	0.57007652
47	MP0009763_increased_sensitivity_to	0.56536244
48	MP0001485_abnormal_pinna_reflex	0.56054498
49	MP0002163_abnormal_gland_morphology	0.55577713
50	MP0005508_abnormal_skeleton_morphology	0.55325222
51	MP0005253_abnormal_eye_physiology	0.55207473
52	MP0002405_respiratory_system_inflammati	0.53809298
53	MP0001175_abnormal_lung_morphology	0.53781488
54	MP0000681_abnormal_thyroid_gland	0.53779333
55	MP0001986_abnormal_taste_sensitivity	0.53748787
56	MP0006292_abnormal_olfactory_placode	0.53603806
57	MP0006276_abnormal_autonomic_nervous	0.53016724
58	MP0009379_abnormal_foot_pigmentation	0.51435263
59	MP0003935_abnormal_craniofacial_develop	0.51416960
60	MP0009672_abnormal_birth_weight	0.49442208
61	MP0002735_abnormal_chemical_nociception	0.49022870
62	MP0003878_abnormal_ear_physiology	0.48186405
63	MP0005377_hearing/vestibular/ear_phenot	0.48186405
64	MP0000049_abnormal_middle_ear	0.48166378
65	MP0003195_calcinosis	0.47884043
66	MP0002752_abnormal_somatic_nervous	0.47368727
67	MP0005391_vision/eye_phenotype	0.47122821
68	MP0004742_abnormal_vestibular_system	0.46559467
69	MP0005645_abnormal_hypothalamus_physiol	0.43755697
70	MP0002113_abnormal_skeleton_development	0.43452781
71	MP0005423_abnormal_somatic_nervous	0.42758099
72	MP0003936_abnormal_reproductive_system	0.42483304
73	MP0005646_abnormal_pituitary_gland	0.40866288
74	MP0000604_amyloidosis	0.40177810
75	MP0005023_abnormal_wound_healing	0.38822442
76	MP0003122_maternal_imprinting	0.38192862
77	MP0000163_abnormal_cartilage_morphology	0.37938085
78	MP0008058_abnormal_DNA_repair	0.37908637
79	MP0003315_abnormal_perineum_morphology	0.37556649
80	MP0000377_abnormal_hair_follicle	0.37363085
81	MP0002277_abnormal_respiratory_mucosa	0.35921041
82	MP0003136_yellow_coat_color	0.35797085
83	MP0002822_catalepsy	0.35590996
84	MP0001968_abnormal_touch/_nociception	0.35411514
85	MP0004885_abnormal_endolymph	0.35317777
86	MP0004145_abnormal_muscle_electrophysio	0.34717359
87	MP0002736_abnormal_nociception_after	0.34347950
88	MP0000955_abnormal_spinal_cord	0.33905669
89	MP0002697_abnormal_eye_size	0.33495995
90	MP0003638_abnormal_response/metabolism_	0.33340997
91	MP0002136_abnormal_kidney_physiology	0.31441050
92	MP0000627_abnormal_mammary_gland	0.30500490
93	MP0005379_endocrine/exocrine_gland_phen	0.29221085
94	MP0005195_abnormal_posterior_eye	0.28769208
95	MP0003880_abnormal_central_pattern	0.28558427
96	MP0002092_abnormal_eye_morphology	0.27752520
97	MP0003011_delayed_dark_adaptation	0.27575841
98	MP0002168_other_aberrant_phenotype	0.24783835
99	MP0008875_abnormal_xenobiotic_pharmacok	0.23357718
100	MP0010771_integument_phenotype	0.22567422

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Duplicated collecting system (HP:0000081)	9.45334054
2	Long foot (HP:0001833)	8.88207599
3	Abnormality of the renal collecting system (HP:0004742)	8.57091427
4	Large for gestational age (HP:0001520)	7.39757035
5	Acute lymphatic leukemia (HP:0006721)	7.05556788
6	Adactyly (HP:0009776)	6.76042991
7	Progressive muscle weakness (HP:0003323)	6.37434065
8	Abnormality of fatty-acid metabolism (HP:0004359)	6.19705029
9	Hypoplastic pelvis (HP:0008839)	5.89185049
10	Dry hair (HP:0011359)	5.46108566
11	Autoamputation (HP:0001218)	5.41697172
12	Pulmonary artery stenosis (HP:0004415)	5.40912584
13	Ureteral stenosis (HP:0000071)	5.12401284
14	Ureteral duplication (HP:0000073)	5.10725386
15	Brushfield spots (HP:0001088)	5.00366207
16	Menstrual irregularities (HP:0000858)	4.99643171
17	Steatorrhea (HP:0002570)	4.98466827
18	Ureteral obstruction (HP:0006000)	4.72364836
19	Hypoplastic nipples (HP:0002557)	4.70967489
20	Severe muscular hypotonia (HP:0006829)	4.28460133
21	Abnormal auditory evoked potentials (HP:0006958)	4.14155753
22	Sudden death (HP:0001699)	4.13569358
23	Increased number of teeth (HP:0011069)	4.13445171
24	Reduced subcutaneous adipose tissue (HP:0003758)	4.11911835
25	Abnormal ventriculo-arterial connection (HP:0011563)	4.02132771
26	Transposition of the great arteries (HP:0001669)	4.02132771
27	Abnormal connection of the cardiac segments (HP:0011545)	4.02132771
28	Broad-based gait (HP:0002136)	3.96718750
29	Fat malabsorption (HP:0002630)	3.84746253
30	Decreased lacrimation (HP:0000633)	3.76625705
31	Anhidrosis (HP:0000970)	3.66690244
32	Wide intermamillary distance (HP:0006610)	3.64731371
33	Palmoplantar hyperkeratosis (HP:0000972)	3.49395946
34	Decreased muscle mass (HP:0003199)	3.30023921
35	Palmar hyperkeratosis (HP:0010765)	3.28030058
36	Polymicrogyria (HP:0002126)	3.17416355
37	Myoglobinuria (HP:0002913)	3.04384670
38	Abnormality of vision evoked potentials (HP:0000649)	3.03722760
39	Polyneuropathy (HP:0001271)	2.96518503
40	Generalized amyotrophy (HP:0003700)	2.92612914
41	Broad nasal tip (HP:0000455)	2.91511790
42	Flat face (HP:0012368)	2.85007159
43	Plantar hyperkeratosis (HP:0007556)	2.81009676
44	Rhabdomyolysis (HP:0003201)	2.79555490
45	Large hands (HP:0001176)	2.76237816
46	Chorioretinal coloboma (HP:0000567)	2.61797703
47	Overfolded helix (HP:0000396)	2.61032653
48	Epiphyseal stippling (HP:0010655)	2.53395051
49	Clubbing of toes (HP:0100760)	2.53294879
50	Widely spaced teeth (HP:0000687)	2.50632964
51	Steppage gait (HP:0003376)	2.42575924
52	Thickened calvaria (HP:0002684)	2.40149175
53	Posterior embryotoxon (HP:0000627)	2.35406586
54	Abnormally folded helix (HP:0008544)	2.34747381
55	Hypoplastic iliac wings (HP:0002866)	2.31837617
56	Abnormality of the line of Schwalbe (HP:0008048)	2.27732165
57	Basal ganglia calcification (HP:0002135)	2.23452627
58	Purpura (HP:0000979)	2.16915961
59	Female pseudohermaphroditism (HP:0010458)	2.14984156
60	Anxiety (HP:0000739)	2.14369746
61	Aplasia/Hypoplasia of the nipples (HP:0006709)	2.10473394
62	Spastic tetraplegia (HP:0002510)	2.07182279
63	Foot dorsiflexor weakness (HP:0009027)	2.04985099
64	Thickened nuchal skin fold (HP:0000474)	2.04755288
65	Absent toe (HP:0010760)	2.02977451
66	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	12.0369558
67	Prenatal maternal abnormality (HP:0002686)	1.92477332
68	Depressed nasal ridge (HP:0000457)	1.88925368
69	Abnormality of the foot musculature (HP:0001436)	1.86731561
70	Arthrogryposis multiplex congenita (HP:0002804)	1.82227655
71	Generalized muscle weakness (HP:0003324)	1.81779437
72	Hammertoe (HP:0001765)	1.81514393
73	Congenital onset (HP:0003577)	1.81233715
74	External ear malformation (HP:0008572)	1.81053790
75	Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)	1.80567744
76	Stereotypic behavior (HP:0000733)	1.78309188
77	Abnormal epiphyseal ossification (HP:0010656)	1.75082246
78	Scrotal hypoplasia (HP:0000046)	1.73522124
79	Lactic acidosis (HP:0003128)	1.73289991
80	Primary adrenal insufficiency (HP:0008207)	1.68004516
81	Decreased motor nerve conduction velocity (HP:0003431)	1.60958452
82	Gangrene (HP:0100758)	1.60372845
83	Decreased number of peripheral myelinated nerve fibers (HP:0003380)	1.58407865
84	Brachycephaly (HP:0000248)	1.55702778
85	Aplasia/Hypoplasia involving the pelvis (HP:0009103)	1.54130342
86	Abnormality of the epiphyses of the hand (HP:0005924)	1.52096862
87	Arterial thrombosis (HP:0004420)	1.51218964
88	Abnormal respiratory motile cilium morphology (HP:0005938)	1.48753511
89	Abnormal respiratory epithelium morphology (HP:0012253)	1.48753511
90	Abnormality involving the epiphyses of the upper limbs (HP:0003839)	1.48711470
91	Nail dystrophy (HP:0008404)	1.46982775
92	Underdeveloped supraorbital ridges (HP:0009891)	1.46254925
93	Hypoplastic ilia (HP:0000946)	1.45563458
94	Webbed neck (HP:0000465)	1.45401636
95	Short philtrum (HP:0000322)	1.44746802
96	Absent/shortened dynein arms (HP:0200106)	1.39388710
97	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.39388710
98	Retinitis pigmentosa (HP:0000510)	1.33467791
99	Fine hair (HP:0002213)	1.33112061
100	Retinopathy (HP:0000488)	1.32658263

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MKNK1	6.83268428
2	TAOK2	5.57832934
3	TAOK1	5.44129539
4	MAP3K3	4.02579423
5	MAP3K11	4.00372524
6	MAP2K3	3.89130928
7	JAK3	2.41537963
8	MKNK2	11.5596694
9	ABL2	1.96466948
10	DYRK1A	1.80533642
11	MAP3K5	1.33259403
12	MAP3K1	0.99956255
13	SRPK1	0.89199713
14	CHEK2	0.79315600
15	MAP3K8	0.63413613
16	PRKCQ	0.53913255
17	WNK3	0.40035023
18	TIE1	0.29992606
19	CSNK1A1	0.20323613
20	SIK2	0.19185313
21	INSRR	0.18425074
22	FRK	0.17919534
23	ADRBK2	0.16894948
24	GRK1	0.15919036
25	OBSCN	0.14257630
26	MAP4K2	0.14073751
27	ABL1	0.14068899
28	IGF1R	0.13137676
29	WNK4	0.10931517
30	PRKCD	0.10610215
31	TLK1	0.09666858
32	CSNK2A2	0.09609920
33	MUSK	0.08260036
34	CSNK1E	0.08239707
35	NTRK2	0.05271181
36	GRK7	0.04048808
37	TXK	0.03547822
38	CSNK2A1	0.03488881
39	MAPK15	0.03157000
40	CASK	0.02843529
41	EPHB2	0.02791863
42	AURKA	0.02705459
43	DYRK2	0.02691493
44	PRKCA	0.02227775
45	PRKCG	0.02033544
46	GRK5	0.01916962
47	PDK2	0.01643667
48	PRKD3	0.01413737
49	PRKACA	0.00669721
50	PAK3	0.00619510
51	EPHA4	0.00227648
52	PRKG1	-0.1037627
53	SYK	-0.1021945
54	PRKACG	-0.1007046
55	EPHA2	-0.0958798
56	MAPK14	-0.0933735
57	CAMK2G	-0.0931364
58	FLT3	-0.0893819
59	CDK2	-0.0891532
60	MAP2K6	-0.0853030
61	VRK2	-0.0829047
62	DAPK3	-0.0800385
63	NTRK1	-0.0770469
64	WNK1	-0.0769937
65	CAMK2A	-0.0765444
66	MAPK13	-0.0758741
67	ITK	-0.0750614
68	PRKCE	-0.0715468
69	PRKCH	-0.0714555
70	DDR2	-0.0697995
71	BTK	-0.0697439
72	MAP2K7	-0.0668956
73	LMTK2	-0.0656121
74	MARK1	-0.0592181
75	PKN1	-0.0512994
76	ZAK	-0.0501631
77	PIK3CG	-0.0484967
78	TAF1	-0.0465961
79	STK39	-0.0440410
80	PLK4	-0.0437763
81	KIT	-0.0436937
82	CAMKK2	-0.0434518
83	PIK3CA	-0.0407616
84	CAMK1	-0.0387358
85	MATK	-0.0380492
86	PHKG2	-0.0370342
87	PHKG1	-0.0370342
88	MAPKAPK5	-0.0354390
89	ERBB4	-0.0305654
90	ADRBK1	-0.0304657
91	PIM2	-0.0284174
92	SRC	-0.0280717
93	TNIK	-0.0269880
94	KDR	-0.0255351
95	OXSR1	-0.0137683
96	TEC	-0.0104465
97	NUAK1	-0.0093578
98	PRKCB	-0.0075476
99	VRK1	-0.0068127
100	PINK1	-0.0003408

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	8.18276386
2	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	6.90341273
3	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.37209634
4	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	3.19803813
5	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	3.10559020
6	RNA polymerase_Homo sapiens_hsa03020	3.04492903
7	Taste transduction_Homo sapiens_hsa04742	3.02620875
8	Butanoate metabolism_Homo sapiens_hsa00650	2.73151922
9	Fatty acid elongation_Homo sapiens_hsa00062	2.49769913
10	Lysine degradation_Homo sapiens_hsa00310	2.36451586
11	beta-Alanine metabolism_Homo sapiens_hsa00410	1.95014847
12	One carbon pool by folate_Homo sapiens_hsa00670	1.87935523
13	Tryptophan metabolism_Homo sapiens_hsa00380	1.83259652
14	Glycerolipid metabolism_Homo sapiens_hsa00561	1.80625786
15	Proteasome_Homo sapiens_hsa03050	1.65915445
16	Propanoate metabolism_Homo sapiens_hsa00640	1.62760480
17	Amoebiasis_Homo sapiens_hsa05146	1.52981229
18	Fatty acid degradation_Homo sapiens_hsa00071	1.26261857
19	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.15249824
20	Peroxisome_Homo sapiens_hsa04146	1.08277065
21	Fatty acid metabolism_Homo sapiens_hsa01212	1.06573671
22	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	1.01898318
23	Viral myocarditis_Homo sapiens_hsa05416	1.01750268
24	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.95516469
25	Complement and coagulation cascades_Homo sapiens_hsa04610	0.86257634
26	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.83201914
27	Nicotine addiction_Homo sapiens_hsa05033	0.78312138
28	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.73723949
29	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.68245245
30	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.67486345
31	Ribosome_Homo sapiens_hsa03010	0.67353490
32	Linoleic acid metabolism_Homo sapiens_hsa00591	0.67008843
33	Caffeine metabolism_Homo sapiens_hsa00232	0.66995370
34	Asthma_Homo sapiens_hsa05310	0.61607928
35	Pyrimidine metabolism_Homo sapiens_hsa00240	0.59794935
36	AMPK signaling pathway_Homo sapiens_hsa04152	0.58519508
37	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.58236637
38	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.57717870
39	Cholinergic synapse_Homo sapiens_hsa04725	0.57647551
40	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.56059418
41	Olfactory transduction_Homo sapiens_hsa04740	0.55763248
42	Retinol metabolism_Homo sapiens_hsa00830	0.55033698
43	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.52886800
44	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.51432869
45	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.49782443
46	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.48993761
47	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.48422647
48	Fat digestion and absorption_Homo sapiens_hsa04975	0.48338770
49	Nucleotide excision repair_Homo sapiens_hsa03420	0.48184796
50	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.47207763
51	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.47162144
52	Cardiac muscle contraction_Homo sapiens_hsa04260	0.45275041
53	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.44764136
54	Phototransduction_Homo sapiens_hsa04744	0.44053917
55	GnRH signaling pathway_Homo sapiens_hsa04912	0.43940805
56	Chemical carcinogenesis_Homo sapiens_hsa05204	0.43449296
57	Salmonella infection_Homo sapiens_hsa05132	0.41967078
58	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.38508773
59	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.37819619
60	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.37758205
61	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.37690045
62	Type I diabetes mellitus_Homo sapiens_hsa04940	0.37022577
63	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.36444481
64	MicroRNAs in cancer_Homo sapiens_hsa05206	0.35949099
65	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.35615529
66	Graft-versus-host disease_Homo sapiens_hsa05332	0.35123491
67	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.33188458
68	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.33052888
69	Allograft rejection_Homo sapiens_hsa05330	0.32757810
70	Huntingtons disease_Homo sapiens_hsa05016	0.32551096
71	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.30742989
72	Choline metabolism in cancer_Homo sapiens_hsa05231	0.30319652
73	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.29421321
74	Nitrogen metabolism_Homo sapiens_hsa00910	0.29375958
75	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.28777899
76	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.28626356
77	RNA transport_Homo sapiens_hsa03013	0.27097659
78	Purine metabolism_Homo sapiens_hsa00230	0.26257386
79	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.25596162
80	Protein digestion and absorption_Homo sapiens_hsa04974	0.25336504
81	Phagosome_Homo sapiens_hsa04145	0.25140372
82	Tyrosine metabolism_Homo sapiens_hsa00350	0.23873236
83	Insulin secretion_Homo sapiens_hsa04911	0.23059244
84	Malaria_Homo sapiens_hsa05144	0.22559508
85	Dopaminergic synapse_Homo sapiens_hsa04728	0.22128626
86	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.21568762
87	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.20837727
88	Metabolic pathways_Homo sapiens_hsa01100	0.18989335
89	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.16970167
90	Morphine addiction_Homo sapiens_hsa05032	0.16611553
91	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.15820738
92	Phenylalanine metabolism_Homo sapiens_hsa00360	0.15032636
93	Pancreatic secretion_Homo sapiens_hsa04972	0.14832296
94	Rheumatoid arthritis_Homo sapiens_hsa05323	0.14697808
95	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.13477131
96	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.13466583
97	Basal cell carcinoma_Homo sapiens_hsa05217	0.13053283
98	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.12486264
99	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.12160994
100	MAPK signaling pathway_Homo sapiens_hsa04010	0.12140829

GAPDHP59

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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