GAPDHP60

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.18688710
2ATP synthesis coupled proton transport (GO:0015986)6.02560842
3energy coupled proton transport, down electrochemical gradient (GO:0015985)6.02560842
4establishment of protein localization to mitochondrial membrane (GO:0090151)5.79519567
5mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.36759648
6proteasome assembly (GO:0043248)5.12124398
7chaperone-mediated protein transport (GO:0072321)5.06669297
8protein complex biogenesis (GO:0070271)4.94967325
9protein neddylation (GO:0045116)4.88282663
10respiratory electron transport chain (GO:0022904)4.79902714
11mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.71963375
12mitochondrial respiratory chain complex I assembly (GO:0032981)4.71963375
13NADH dehydrogenase complex assembly (GO:0010257)4.71963375
14electron transport chain (GO:0022900)4.71829860
15mitochondrial respiratory chain complex assembly (GO:0033108)4.56186953
16DNA deamination (GO:0045006)4.40168733
17ribosomal small subunit assembly (GO:0000028)4.05907714
18termination of RNA polymerase III transcription (GO:0006386)3.97104430
19transcription elongation from RNA polymerase III promoter (GO:0006385)3.97104430
20cullin deneddylation (GO:0010388)3.93290434
21rRNA modification (GO:0000154)3.91320762
22negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.88757119
23regulation of cellular amino acid metabolic process (GO:0006521)3.70482844
24protein deneddylation (GO:0000338)3.69845647
25peptidyl-histidine modification (GO:0018202)3.63364132
26nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.61216730
27DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.58891144
28respiratory chain complex IV assembly (GO:0008535)3.55742983
29exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.54787450
30signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.52421971
31signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.52421971
32signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.52421971
33positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.51439444
34pseudouridine synthesis (GO:0001522)3.51386879
35water-soluble vitamin biosynthetic process (GO:0042364)3.50282377
36ATP biosynthetic process (GO:0006754)3.50199130
37hydrogen ion transmembrane transport (GO:1902600)3.50059381
38intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.48584658
39signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.48584658
40negative regulation of ligase activity (GO:0051352)3.46055583
41negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.46055583
42regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.45673347
43purine nucleoside triphosphate biosynthetic process (GO:0009145)3.45039368
44DNA double-strand break processing (GO:0000729)3.40264487
45protein-cofactor linkage (GO:0018065)3.39386266
46purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.39346981
47translation (GO:0006412)3.35103068
48signal transduction involved in DNA damage checkpoint (GO:0072422)3.34603323
49signal transduction involved in DNA integrity checkpoint (GO:0072401)3.34603323
50inner mitochondrial membrane organization (GO:0007007)3.31839060
51signal transduction involved in cell cycle checkpoint (GO:0072395)3.31400147
52SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.31254706
53cotranslational protein targeting to membrane (GO:0006613)3.29403992
54protein targeting to ER (GO:0045047)3.26589380
55maturation of SSU-rRNA (GO:0030490)3.25775453
56proton transport (GO:0015992)3.21130437
57maturation of 5.8S rRNA (GO:0000460)3.20775220
58intracellular protein transmembrane import (GO:0044743)3.20771042
59viral transcription (GO:0019083)3.20155702
60rRNA methylation (GO:0031167)3.18339010
61protein targeting to mitochondrion (GO:0006626)3.16581193
62establishment of protein localization to endoplasmic reticulum (GO:0072599)3.16035603
63DNA damage response, detection of DNA damage (GO:0042769)3.15231650
64hydrogen transport (GO:0006818)3.14883233
65translational termination (GO:0006415)3.14066207
66anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.13980421
67cytochrome complex assembly (GO:0017004)3.12843850
68cellular component biogenesis (GO:0044085)3.08969061
69ribosomal large subunit biogenesis (GO:0042273)3.08491383
70protein localization to endoplasmic reticulum (GO:0070972)3.07950241
71spliceosomal snRNP assembly (GO:0000387)3.05685583
72GTP biosynthetic process (GO:0006183)3.04981844
73establishment of protein localization to mitochondrion (GO:0072655)3.03400699
74tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.01167873
75RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.01167873
76deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.00542520
77nucleobase biosynthetic process (GO:0046112)2.99044661
78aldehyde catabolic process (GO:0046185)2.98920409
79ribonucleoside triphosphate biosynthetic process (GO:0009201)2.98789813
80rRNA processing (GO:0006364)2.98400068
81protein localization to mitochondrion (GO:0070585)2.98178642
82positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.97109119
83tRNA processing (GO:0008033)2.95251242
84translational elongation (GO:0006414)2.94632169
85rRNA metabolic process (GO:0016072)2.93616905
86chromatin remodeling at centromere (GO:0031055)2.91744643
87regulation of mitochondrial translation (GO:0070129)2.89867775
88response to pheromone (GO:0019236)2.89206431
89positive regulation of ligase activity (GO:0051351)2.88679579
90mannosylation (GO:0097502)2.88112201
91L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.88024785
92purine nucleoside monophosphate biosynthetic process (GO:0009127)2.86191244
93purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.86191244
94CENP-A containing nucleosome assembly (GO:0034080)2.84267890
95purine nucleobase biosynthetic process (GO:0009113)2.82397357
96DNA catabolic process, exonucleolytic (GO:0000738)2.81586271
97translational initiation (GO:0006413)2.80299580
98regulation of nuclear cell cycle DNA replication (GO:0033262)2.77540302
99oxidative phosphorylation (GO:0006119)2.75744939
100nucleoside triphosphate biosynthetic process (GO:0009142)2.74825481

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.31023539
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.99310513
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.73689139
4EST1_17652178_ChIP-ChIP_JURKAT_Human4.45888493
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.35586094
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.32463777
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.14659214
8ETS1_20019798_ChIP-Seq_JURKAT_Human2.97819258
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.78876340
10CREB1_15753290_ChIP-ChIP_HEK293T_Human2.77557684
11VDR_23849224_ChIP-Seq_CD4+_Human2.74562248
12ELK1_19687146_ChIP-ChIP_HELA_Human2.68652188
13CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.65003591
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.60068851
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.50301497
16ZNF274_21170338_ChIP-Seq_K562_Hela2.48750864
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.36747547
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.34132730
19FOXP3_21729870_ChIP-Seq_TREG_Human2.32464926
20FLI1_27457419_Chip-Seq_LIVER_Mouse2.23080302
21E2F4_17652178_ChIP-ChIP_JURKAT_Human2.11715645
22PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.10426588
23VDR_22108803_ChIP-Seq_LS180_Human2.05758888
24SRF_21415370_ChIP-Seq_HL-1_Mouse2.04901092
25MYC_18358816_ChIP-ChIP_MESCs_Mouse1.88595206
26EWS_26573619_Chip-Seq_HEK293_Human1.82157377
27MYC_18940864_ChIP-ChIP_HL60_Human1.81061685
28PCGF2_27294783_Chip-Seq_ESCs_Mouse1.78572632
29DCP1A_22483619_ChIP-Seq_HELA_Human1.76419265
30IGF1R_20145208_ChIP-Seq_DFB_Human1.74383070
31MYC_19030024_ChIP-ChIP_MESCs_Mouse1.71951998
32FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.69968051
33FUS_26573619_Chip-Seq_HEK293_Human1.66698164
34THAP11_20581084_ChIP-Seq_MESCs_Mouse1.60956555
35TTF2_22483619_ChIP-Seq_HELA_Human1.60452209
36YY1_21170310_ChIP-Seq_MESCs_Mouse1.59246604
37NOTCH1_21737748_ChIP-Seq_TLL_Human1.57895141
38PADI4_21655091_ChIP-ChIP_MCF-7_Human1.55871585
39PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55864077
40TP53_22573176_ChIP-Seq_HFKS_Human1.53594180
41GABP_19822575_ChIP-Seq_HepG2_Human1.51372121
42HOXB4_20404135_ChIP-ChIP_EML_Mouse1.48041844
43E2F1_18555785_ChIP-Seq_MESCs_Mouse1.43687596
44HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.40810861
45EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.37263464
46CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.36206618
47MYC_19079543_ChIP-ChIP_MESCs_Mouse1.35302521
48GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26455614
49PCGF2_27294783_Chip-Seq_NPCs_Mouse1.26193590
50ELK1_22589737_ChIP-Seq_MCF10A_Human1.25765410
51IRF1_19129219_ChIP-ChIP_H3396_Human1.25580077
52CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.24216012
53MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.21710869
54ZFP57_27257070_Chip-Seq_ESCs_Mouse1.21296913
55XRN2_22483619_ChIP-Seq_HELA_Human1.20967243
56POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.19939564
57EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.17627390
58SOX2_19829295_ChIP-Seq_ESCs_Human1.17410514
59NANOG_19829295_ChIP-Seq_ESCs_Human1.17410514
60YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14320963
61POU3F2_20337985_ChIP-ChIP_501MEL_Human1.13256353
62P300_19829295_ChIP-Seq_ESCs_Human1.12736759
63ER_23166858_ChIP-Seq_MCF-7_Human1.12203306
64GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.11513411
65ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.11028098
66GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.08626949
67FOXA1_25329375_ChIP-Seq_VCAP_Human1.07824735
68FOXA1_27270436_Chip-Seq_PROSTATE_Human1.07824735
69CTBP1_25329375_ChIP-Seq_LNCAP_Human1.07147091
70ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.06885903
71MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.04852601
72AR_20517297_ChIP-Seq_VCAP_Human1.04462003
73SUZ12_27294783_Chip-Seq_NPCs_Mouse1.02917932
74NELFA_20434984_ChIP-Seq_ESCs_Mouse1.01934262
75NFE2_27457419_Chip-Seq_LIVER_Mouse1.01523421
76CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.01518586
77CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.99494395
78HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.96626340
79FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.92951715
80CTBP2_25329375_ChIP-Seq_LNCAP_Human0.92685148
81GATA3_21878914_ChIP-Seq_MCF-7_Human0.92197834
82HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.91849197
83EGR1_23403033_ChIP-Seq_LIVER_Mouse0.91846310
84FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.91456558
85CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.91021204
86NCOR_22424771_ChIP-Seq_293T_Human0.90010323
87POU5F1_16153702_ChIP-ChIP_HESCs_Human0.89381354
88TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88972129
89EZH2_27294783_Chip-Seq_NPCs_Mouse0.87724844
90AUTS2_25519132_ChIP-Seq_293T-REX_Human0.85819344
91ETV2_25802403_ChIP-Seq_MESCs_Mouse0.85585094
92KDM5A_27292631_Chip-Seq_BREAST_Human0.81034612
93IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.80455653
94CBP_20019798_ChIP-Seq_JUKART_Human0.80455653
95PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.80278853
96KLF5_20875108_ChIP-Seq_MESCs_Mouse0.79978758
97SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.79803165
98ERG_20517297_ChIP-Seq_VCAP_Human0.77645270
99GBX2_23144817_ChIP-Seq_PC3_Human0.77562934
100UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.75988591

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004147_increased_porphyrin_level2.89318720
2MP0005084_abnormal_gallbladder_morpholo2.67069941
3MP0000372_irregular_coat_pigmentation2.63471034
4MP0002102_abnormal_ear_morphology2.63279401
5MP0006292_abnormal_olfactory_placode2.62176580
6MP0008877_abnormal_DNA_methylation2.40875390
7MP0003186_abnormal_redox_activity2.40385878
8MP0003806_abnormal_nucleotide_metabolis2.24114039
9MP0006072_abnormal_retinal_apoptosis2.11828656
10MP0003567_abnormal_fetal_cardiomyocyte2.06986327
11MP0008058_abnormal_DNA_repair2.03200743
12MP0008872_abnormal_physiological_respon1.99646129
13MP0002163_abnormal_gland_morphology1.93233665
14MP0001529_abnormal_vocalization1.90903293
15MP0004885_abnormal_endolymph1.89868910
16MP0003786_premature_aging1.86506865
17MP0009697_abnormal_copulation1.86072498
18MP0002277_abnormal_respiratory_mucosa1.81917764
19MP0002837_dystrophic_cardiac_calcinosis1.81271865
20MP0006036_abnormal_mitochondrial_physio1.72735855
21MP0010094_abnormal_chromosome_stability1.69571876
22MP0005551_abnormal_eye_electrophysiolog1.69034064
23MP0001984_abnormal_olfaction1.66958575
24MP0008789_abnormal_olfactory_epithelium1.65607394
25MP0006035_abnormal_mitochondrial_morpho1.64373611
26MP0009379_abnormal_foot_pigmentation1.64190851
27MP0003011_delayed_dark_adaptation1.63923143
28MP0008875_abnormal_xenobiotic_pharmacok1.63764027
29MP0002736_abnormal_nociception_after1.63365300
30MP0005379_endocrine/exocrine_gland_phen1.59650760
31MP0003693_abnormal_embryo_hatching1.57504266
32MP0005075_abnormal_melanosome_morpholog1.55259458
33MP0001919_abnormal_reproductive_system1.53008300
34MP0003718_maternal_effect1.51831106
35MP0002234_abnormal_pharynx_morphology1.50139669
36MP0002138_abnormal_hepatobiliary_system1.50004496
37MP0003880_abnormal_central_pattern1.48949605
38MP0004142_abnormal_muscle_tone1.45165715
39MP0005389_reproductive_system_phenotype1.43775482
40MP0002160_abnormal_reproductive_system1.43716264
41MP0001968_abnormal_touch/_nociception1.42972102
42MP0001485_abnormal_pinna_reflex1.38536075
43MP0005645_abnormal_hypothalamus_physiol1.37020562
44MP0002938_white_spotting1.36196678
45MP0003878_abnormal_ear_physiology1.34679446
46MP0005377_hearing/vestibular/ear_phenot1.34679446
47MP0001293_anophthalmia1.32487880
48MP0005394_taste/olfaction_phenotype1.31068898
49MP0005499_abnormal_olfactory_system1.31068898
50MP0003646_muscle_fatigue1.28402561
51MP0005646_abnormal_pituitary_gland1.26768091
52MP0005253_abnormal_eye_physiology1.26574053
53MP0004145_abnormal_muscle_electrophysio1.26255582
54MP0005671_abnormal_response_to1.25395274
55MP0004957_abnormal_blastocyst_morpholog1.25224154
56MP0008995_early_reproductive_senescence1.24900168
57MP0001835_abnormal_antigen_presentation1.23969111
58MP0000685_abnormal_immune_system1.23401820
59MP0004742_abnormal_vestibular_system1.22052139
60MP0002876_abnormal_thyroid_physiology1.19746372
61MP0001905_abnormal_dopamine_level1.16647557
62MP0005636_abnormal_mineral_homeostasis1.14235460
63MP0005360_urolithiasis1.13600527
64MP0005387_immune_system_phenotype1.05228768
65MP0001790_abnormal_immune_system1.05228768
66MP0006276_abnormal_autonomic_nervous1.03176324
67MP0001188_hyperpigmentation1.00353452
68MP0009046_muscle_twitch0.99975218
69MP0009745_abnormal_behavioral_response0.98638434
70MP0002751_abnormal_autonomic_nervous0.98062993
71MP0009333_abnormal_splenocyte_physiolog0.96451936
72MP0009785_altered_susceptibility_to0.94320413
73MP0000631_abnormal_neuroendocrine_gland0.92602082
74MP0002272_abnormal_nervous_system0.91905151
75MP0008007_abnormal_cellular_replicative0.89190024
76MP0005332_abnormal_amino_acid0.88618197
77MP0003787_abnormal_imprinting0.88523944
78MP0004133_heterotaxia0.88097234
79MP0002638_abnormal_pupillary_reflex0.87553322
80MP0005410_abnormal_fertilization0.86802917
81MP0002210_abnormal_sex_determination0.86728509
82MP0001929_abnormal_gametogenesis0.85592434
83MP0004043_abnormal_pH_regulation0.81505469
84MP0000427_abnormal_hair_cycle0.81193238
85MP0001764_abnormal_homeostasis0.80997144
86MP0000653_abnormal_sex_gland0.76377800
87MP0002006_tumorigenesis0.76230307
88MP0003195_calcinosis0.75882957
89MP0002148_abnormal_hypersensitivity_rea0.75224930
90MP0003111_abnormal_nucleus_morphology0.74672305
91MP0003077_abnormal_cell_cycle0.72812189
92MP0001348_abnormal_lacrimal_gland0.72292948
93MP0001501_abnormal_sleep_pattern0.70577486
94MP0001800_abnormal_humoral_immune0.70412611
95MP0001881_abnormal_mammary_gland0.69586186
96MP0001486_abnormal_startle_reflex0.69300289
97MP0000358_abnormal_cell_content/0.68404185
98MP0009764_decreased_sensitivity_to0.67569251
99MP0002095_abnormal_skin_pigmentation0.66708928
100MP0004215_abnormal_myocardial_fiber0.66658998

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.72031413
2Acute encephalopathy (HP:0006846)5.29546240
3Abnormal mitochondria in muscle tissue (HP:0008316)5.13743568
4Mitochondrial inheritance (HP:0001427)5.03585165
5Increased hepatocellular lipid droplets (HP:0006565)4.95703665
6Increased CSF lactate (HP:0002490)4.71724709
7Progressive macrocephaly (HP:0004481)4.71259607
8Lipid accumulation in hepatocytes (HP:0006561)4.59113602
9Renal Fanconi syndrome (HP:0001994)4.16251214
103-Methylglutaconic aciduria (HP:0003535)4.10980373
11Hepatocellular necrosis (HP:0001404)4.07210830
12Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.94797674
13Hepatic necrosis (HP:0002605)3.85511625
14Cerebral edema (HP:0002181)3.71867898
15Increased intramyocellular lipid droplets (HP:0012240)3.51158902
16Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.42540368
17Increased serum lactate (HP:0002151)3.33842676
18Exertional dyspnea (HP:0002875)3.32937577
19Optic disc pallor (HP:0000543)3.19252670
20Lactic acidosis (HP:0003128)3.10133851
21Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.95186719
22Decreased activity of mitochondrial respiratory chain (HP:0008972)2.95186719
23Exercise intolerance (HP:0003546)2.90396549
24Increased muscle lipid content (HP:0009058)2.89103163
25Respiratory failure (HP:0002878)2.84668331
26Abnormality of the renal cortex (HP:0011035)2.83674123
27Renal cortical cysts (HP:0000803)2.76760443
28Congenital, generalized hypertrichosis (HP:0004540)2.75961038
29Pancreatic cysts (HP:0001737)2.67623521
30Abnormality of renal resorption (HP:0011038)2.59654003
31Glycosuria (HP:0003076)2.57870150
32Abnormality of urine glucose concentration (HP:0011016)2.57870150
33Leukodystrophy (HP:0002415)2.57791736
34Lethargy (HP:0001254)2.54655593
35Respiratory difficulties (HP:0002880)2.52672351
36Abnormality of the labia minora (HP:0012880)2.50200998
37Hypothermia (HP:0002045)2.43090875
38Aplasia/hypoplasia of the uterus (HP:0008684)2.42182653
39Abnormality of midbrain morphology (HP:0002418)2.39706265
40Molar tooth sign on MRI (HP:0002419)2.39706265
41Abnormal number of erythroid precursors (HP:0012131)2.38667621
42Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.35343353
43Abnormality of alanine metabolism (HP:0010916)2.35343353
44Hyperalaninemia (HP:0003348)2.35343353
45Abolished electroretinogram (ERG) (HP:0000550)2.34923305
46Colon cancer (HP:0003003)2.34049758
47Pancreatic fibrosis (HP:0100732)2.31985544
48Medial flaring of the eyebrow (HP:0010747)2.23469858
49Generalized aminoaciduria (HP:0002909)2.22192827
50Type I transferrin isoform profile (HP:0003642)2.20458071
51Degeneration of anterior horn cells (HP:0002398)2.19271410
52Abnormality of the anterior horn cell (HP:0006802)2.19271410
53True hermaphroditism (HP:0010459)2.18716555
54Abnormality of cells of the erythroid lineage (HP:0012130)2.14377937
55Congenital stationary night blindness (HP:0007642)2.11833580
56Hyperglycinemia (HP:0002154)2.08614295
57Reticulocytopenia (HP:0001896)2.05357995
58IgG deficiency (HP:0004315)2.02754238
59Hypoplasia of the uterus (HP:0000013)2.02288067
60Hyperphosphaturia (HP:0003109)2.00936360
61Methylmalonic aciduria (HP:0012120)1.91182803
62Decreased electroretinogram (ERG) amplitude (HP:0000654)1.90580221
63CNS demyelination (HP:0007305)1.88939879
64Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.88491448
65Abnormal protein N-linked glycosylation (HP:0012347)1.88491448
66Abnormal protein glycosylation (HP:0012346)1.88491448
67Abnormal glycosylation (HP:0012345)1.88491448
68Nephronophthisis (HP:0000090)1.88275103
69Constricted visual fields (HP:0001133)1.86793865
70Septo-optic dysplasia (HP:0100842)1.86097602
71Hyperglycinuria (HP:0003108)1.84961156
72Sclerocornea (HP:0000647)1.84920060
73Meckel diverticulum (HP:0002245)1.83473240
74Pendular nystagmus (HP:0012043)1.83155000
75Methylmalonic acidemia (HP:0002912)1.81331407
76Type II lissencephaly (HP:0007260)1.79580741
77Aplastic anemia (HP:0001915)1.79236555
78Abnormality of serum amino acid levels (HP:0003112)1.78927641
79Hypoproteinemia (HP:0003075)1.77661138
80Increased serum pyruvate (HP:0003542)1.77508438
81Abnormality of the renal medulla (HP:0100957)1.77292757
82Abnormality of the ileum (HP:0001549)1.77202760
83X-linked dominant inheritance (HP:0001423)1.75948133
84Blindness (HP:0000618)1.75089479
85Abnormal rod and cone electroretinograms (HP:0008323)1.74909554
86Hypomagnesemia (HP:0002917)1.74281051
87Cerebral hypomyelination (HP:0006808)1.74259937
88Macrocytic anemia (HP:0001972)1.72820005
89Pancytopenia (HP:0001876)1.71987769
90Dyschromatopsia (HP:0007641)1.71669242
91Abnormality of aspartate family amino acid metabolism (HP:0010899)1.71227136
92Testicular atrophy (HP:0000029)1.70896991
93Delayed CNS myelination (HP:0002188)1.69351625
94Attenuation of retinal blood vessels (HP:0007843)1.67395804
95Tubular atrophy (HP:0000092)1.67200947
96Absent rod-and cone-mediated responses on ERG (HP:0007688)1.66167609
97IgM deficiency (HP:0002850)1.65515147
98Aplasia/Hypoplasia of the uvula (HP:0010293)1.64845843
99Polyuria (HP:0000103)1.61605945
100Abnormality of B cell number (HP:0010975)1.59061753

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.47106387
2BUB12.76522678
3ZAK2.73384105
4MST42.70202423
5VRK12.70062780
6EIF2AK32.60165835
7TLK12.29559716
8MAP4K22.22835430
9NUAK12.13607889
10TXK2.08483369
11BMPR1B2.07928142
12GRK12.02440384
13MAP3K122.00155006
14TIE11.99747683
15EIF2AK11.89743771
16TSSK61.83684350
17OXSR11.82239642
18ADRBK21.77306819
19PBK1.75223340
20SRPK11.72610820
21STK391.68332181
22FRK1.63414913
23BCKDK1.63374644
24NME11.62693714
25PLK31.58136161
26TRIM281.56052995
27TAF11.46007199
28NME21.45703919
29NEK11.44862629
30DYRK21.44482874
31WNK31.43443670
32INSRR1.33153492
33BCR1.29500227
34MAPK131.26434365
35STK161.23873533
36CDC71.21909161
37WNK41.20320618
38PINK11.19961142
39CSNK1G11.08302393
40CSNK1G31.03551596
41EIF2AK21.01654616
42PDK21.01458585
43PHKG20.96172655
44PHKG10.96172655
45TAOK30.94956223
46WEE10.91329421
47CDK80.91185655
48KDR0.90365480
49MKNK10.89909369
50CSNK1G20.87915030
51MKNK20.87354039
52TGFBR10.84149294
53CSNK1A1L0.79738623
54PLK20.78423112
55TNIK0.78350702
56CDK190.77674349
57TEC0.75720254
58PASK0.74051307
59MAP2K60.73660510
60ATR0.70816784
61CCNB10.70085037
62PLK10.67658517
63DAPK10.64782439
64IKBKB0.62579500
65FER0.61554385
66FES0.58467271
67CSNK2A20.58169518
68DAPK30.55326145
69PRKCG0.55292115
70GRK50.55077634
71KIT0.54770184
72TTK0.53851821
73MYLK0.53384613
74ADRBK10.51770815
75FGFR10.51516040
76CSNK2A10.51321593
77PRKCE0.48582354
78MAP4K10.47288046
79AURKB0.47024233
80CLK10.45486702
81PAK30.44918895
82STK40.43786577
83CSNK1A10.43194714
84PRKCI0.42000706
85OBSCN0.41383830
86BMPR20.40478181
87LIMK10.38331359
88AKT30.37580538
89MARK10.37062920
90ATM0.37032547
91PLK40.36740086
92ALK0.35605645
93RPS6KA50.34587149
94PRKCQ0.34407677
95PRKACA0.33580648
96STK38L0.32852061
97ACVR1B0.32384650
98NLK0.32049267
99CSNK1E0.31746909
100ITK0.31018423

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.47745418
2Oxidative phosphorylation_Homo sapiens_hsa001904.31750443
3Parkinsons disease_Homo sapiens_hsa050123.71579827
4Ribosome_Homo sapiens_hsa030103.49669453
5Protein export_Homo sapiens_hsa030603.09264802
6RNA polymerase_Homo sapiens_hsa030202.97734774
7Huntingtons disease_Homo sapiens_hsa050162.48048674
8Alzheimers disease_Homo sapiens_hsa050102.40755204
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.25753774
10Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.11380623
11Homologous recombination_Homo sapiens_hsa034402.05398200
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.98529104
13Non-homologous end-joining_Homo sapiens_hsa034501.89149452
14Mismatch repair_Homo sapiens_hsa034301.86909158
15One carbon pool by folate_Homo sapiens_hsa006701.86572149
16Propanoate metabolism_Homo sapiens_hsa006401.78568107
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.77286833
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.76006412
19RNA degradation_Homo sapiens_hsa030181.70748277
20Cardiac muscle contraction_Homo sapiens_hsa042601.69784180
21DNA replication_Homo sapiens_hsa030301.65100648
22Basal transcription factors_Homo sapiens_hsa030221.57176233
23Pyrimidine metabolism_Homo sapiens_hsa002401.51828197
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.49079283
25Asthma_Homo sapiens_hsa053101.47807060
26Nucleotide excision repair_Homo sapiens_hsa034201.41533879
27Spliceosome_Homo sapiens_hsa030401.40446980
28RNA transport_Homo sapiens_hsa030131.32947521
29Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.32427097
30Intestinal immune network for IgA production_Homo sapiens_hsa046721.28845134
31Allograft rejection_Homo sapiens_hsa053301.28380132
32Purine metabolism_Homo sapiens_hsa002301.27425813
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.23755893
34Fanconi anemia pathway_Homo sapiens_hsa034601.21807250
35Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.19687148
36Base excision repair_Homo sapiens_hsa034101.18620555
37Autoimmune thyroid disease_Homo sapiens_hsa053201.17290398
38Phototransduction_Homo sapiens_hsa047441.15159784
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.09139320
40Type I diabetes mellitus_Homo sapiens_hsa049401.04131026
41Primary immunodeficiency_Homo sapiens_hsa053401.00292809
42Graft-versus-host disease_Homo sapiens_hsa053320.99610450
43Pyruvate metabolism_Homo sapiens_hsa006200.98908696
44Folate biosynthesis_Homo sapiens_hsa007900.96855982
45Peroxisome_Homo sapiens_hsa041460.92913475
46Fatty acid elongation_Homo sapiens_hsa000620.92300136
47Caffeine metabolism_Homo sapiens_hsa002320.86776623
48Butanoate metabolism_Homo sapiens_hsa006500.85634486
49Linoleic acid metabolism_Homo sapiens_hsa005910.81586458
50Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.81138577
51Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.80662277
52Metabolic pathways_Homo sapiens_hsa011000.79739722
53Collecting duct acid secretion_Homo sapiens_hsa049660.73537529
54Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.72465725
55Sulfur metabolism_Homo sapiens_hsa009200.71626878
56Selenocompound metabolism_Homo sapiens_hsa004500.71406037
57Antigen processing and presentation_Homo sapiens_hsa046120.70171470
58Maturity onset diabetes of the young_Homo sapiens_hsa049500.69875963
59Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.68782271
60Glutathione metabolism_Homo sapiens_hsa004800.68093997
61Primary bile acid biosynthesis_Homo sapiens_hsa001200.65784558
62Systemic lupus erythematosus_Homo sapiens_hsa053220.65164125
63Rheumatoid arthritis_Homo sapiens_hsa053230.62481829
64Nitrogen metabolism_Homo sapiens_hsa009100.62439499
65Chemical carcinogenesis_Homo sapiens_hsa052040.62292220
66Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.61761923
67Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.60491684
68alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.58299310
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.57733033
70Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.57206779
71Steroid biosynthesis_Homo sapiens_hsa001000.56228619
72Vitamin B6 metabolism_Homo sapiens_hsa007500.54430934
73Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.51597136
74Tryptophan metabolism_Homo sapiens_hsa003800.47094307
75Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.46331492
76Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.45425617
77Sulfur relay system_Homo sapiens_hsa041220.43668597
78Carbon metabolism_Homo sapiens_hsa012000.41209685
79Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.41203002
80Pentose and glucuronate interconversions_Homo sapiens_hsa000400.40360744
81Retinol metabolism_Homo sapiens_hsa008300.39959053
82SNARE interactions in vesicular transport_Homo sapiens_hsa041300.38699822
83Steroid hormone biosynthesis_Homo sapiens_hsa001400.33509420
84p53 signaling pathway_Homo sapiens_hsa041150.33096824
85Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.31971943
86beta-Alanine metabolism_Homo sapiens_hsa004100.31530802
87Olfactory transduction_Homo sapiens_hsa047400.31135083
88Epstein-Barr virus infection_Homo sapiens_hsa051690.30836295
89Vitamin digestion and absorption_Homo sapiens_hsa049770.30066838
902-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.28034061
91Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.26942634
92Regulation of autophagy_Homo sapiens_hsa041400.26908555
93Arachidonic acid metabolism_Homo sapiens_hsa005900.26397765
94Drug metabolism - other enzymes_Homo sapiens_hsa009830.25617575
95N-Glycan biosynthesis_Homo sapiens_hsa005100.25156632
96Fat digestion and absorption_Homo sapiens_hsa049750.24726082
97Taste transduction_Homo sapiens_hsa047420.24382818
98Hematopoietic cell lineage_Homo sapiens_hsa046400.24012461
99Nicotine addiction_Homo sapiens_hsa050330.22221179
100Mineral absorption_Homo sapiens_hsa049780.21802207

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