

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | positive regulation of mitotic sister chromatid separation (GO:1901970) | 8.98028897 |
| 2 | positive regulation of mitotic metaphase/anaphase transition (GO:0045842) | 8.98028897 |
| 3 | positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101) | 8.98028897 |
| 4 | negative regulation of Ras GTPase activity (GO:0034261) | 8.92008262 |
| 5 | eosinophil chemotaxis (GO:0048245) | 8.69771265 |
| 6 | negative regulation of T cell receptor signaling pathway (GO:0050860) | 8.18434324 |
| 7 | eosinophil migration (GO:0072677) | 7.85574510 |
| 8 | regulation of sister chromatid cohesion (GO:0007063) | 7.75062714 |
| 9 | ribosomal small subunit assembly (GO:0000028) | 7.57757775 |
| 10 | L-fucose metabolic process (GO:0042354) | 7.44852932 |
| 11 | L-fucose catabolic process (GO:0042355) | 7.44852932 |
| 12 | fucose catabolic process (GO:0019317) | 7.44852932 |
| 13 | regulation of mononuclear cell migration (GO:0071675) | 6.74734970 |
| 14 | negative regulation of antigen receptor-mediated signaling pathway (GO:0050858) | 6.36904675 |
| 15 | coenzyme A biosynthetic process (GO:0015937) | 6.17090008 |
| 16 | negative regulation of peptidyl-threonine phosphorylation (GO:0010801) | 6.11778565 |
| 17 | branch elongation of an epithelium (GO:0060602) | 6.01581918 |
| 18 | positive regulation of chromosome segregation (GO:0051984) | 5.89035026 |
| 19 | proteasome assembly (GO:0043248) | 5.61827792 |
| 20 | vesicle fusion (GO:0006906) | 5.48234485 |
| 21 | autophagic vacuole fusion (GO:0000046) | 5.29219166 |
| 22 | negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037) | 5.25125210 |
| 23 | macrophage chemotaxis (GO:0048246) | 5.16558950 |
| 24 | double-strand break repair via nonhomologous end joining (GO:0006303) | 5.06989887 |
| 25 | non-recombinational repair (GO:0000726) | 5.06989887 |
| 26 | regulation of T cell receptor signaling pathway (GO:0050856) | 5.03572496 |
| 27 | peptidyl-lysine dimethylation (GO:0018027) | 4.60738171 |
| 28 | organ growth (GO:0035265) | 4.53657789 |
| 29 | organelle membrane fusion (GO:0090174) | 4.48470459 |
| 30 | localization within membrane (GO:0051668) | 4.47842224 |
| 31 | protein import into peroxisome matrix (GO:0016558) | 4.47435261 |
| 32 | positive regulation of calcium ion import (GO:0090280) | 4.34798483 |
| 33 | iron-sulfur cluster assembly (GO:0016226) | 4.30236040 |
| 34 | metallo-sulfur cluster assembly (GO:0031163) | 4.30236040 |
| 35 | monocyte chemotaxis (GO:0002548) | 4.28772794 |
| 36 | DNA integration (GO:0015074) | 4.21455059 |
| 37 | regulation of nitric-oxide synthase biosynthetic process (GO:0051769) | 4.11612455 |
| 38 | acrosome assembly (GO:0001675) | 4.09183705 |
| 39 | establishment of mitotic spindle orientation (GO:0000132) | 4.03323298 |
| 40 | axis elongation (GO:0003401) | 3.99171198 |
| 41 | purine nucleoside bisphosphate biosynthetic process (GO:0034033) | 3.99138658 |
| 42 | ribonucleoside bisphosphate biosynthetic process (GO:0034030) | 3.99138658 |
| 43 | nucleoside bisphosphate biosynthetic process (GO:0033866) | 3.99138658 |
| 44 | pantothenate metabolic process (GO:0015939) | 3.99055993 |
| 45 | fucose metabolic process (GO:0006004) | 3.98801138 |
| 46 | DNA demethylation (GO:0080111) | 3.95837894 |
| 47 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.91538308 |
| 48 | fucosylation (GO:0036065) | 3.84204878 |
| 49 | detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580) | 3.79877176 |
| 50 | preassembly of GPI anchor in ER membrane (GO:0016254) | 3.77622071 |
| 51 | seminiferous tubule development (GO:0072520) | 3.76639640 |
| 52 | negative regulation of GTP catabolic process (GO:0033125) | 3.71860794 |
| 53 | negative regulation of GTPase activity (GO:0034260) | 3.71860794 |
| 54 | establishment of mitotic spindle localization (GO:0040001) | 3.66582274 |
| 55 | coenzyme A metabolic process (GO:0015936) | 3.62710833 |
| 56 | oxidative demethylation (GO:0070989) | 3.60652324 |
| 57 | mitochondrial RNA metabolic process (GO:0000959) | 3.60206046 |
| 58 | regulation of antigen receptor-mediated signaling pathway (GO:0050854) | 3.52194905 |
| 59 | organelle fusion (GO:0048284) | 3.51545475 |
| 60 | regulation of ER to Golgi vesicle-mediated transport (GO:0060628) | 3.51108333 |
| 61 | telomere maintenance via recombination (GO:0000722) | 3.46835777 |
| 62 | DNA dealkylation (GO:0035510) | 3.39676007 |
| 63 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.37859832 |
| 64 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.35394903 |
| 65 | termination of RNA polymerase III transcription (GO:0006386) | 3.35394903 |
| 66 | establishment of spindle orientation (GO:0051294) | 3.30789168 |
| 67 | positive chemotaxis (GO:0050918) | 3.27590004 |
| 68 | detection of chemical stimulus involved in sensory perception of taste (GO:0050912) | 3.22717085 |
| 69 | cytidine deamination (GO:0009972) | 3.19110632 |
| 70 | cytidine metabolic process (GO:0046087) | 3.19110632 |
| 71 | cytidine catabolic process (GO:0006216) | 3.19110632 |
| 72 | intracellular protein transmembrane import (GO:0044743) | 3.17960706 |
| 73 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.17586386 |
| 74 | DNA deamination (GO:0045006) | 3.16689106 |
| 75 | regulation of beta-amyloid formation (GO:1902003) | 3.16662079 |
| 76 | positive regulation of interleukin-1 beta secretion (GO:0050718) | 3.16102931 |
| 77 | negative regulation of circadian rhythm (GO:0042754) | 3.15483923 |
| 78 | protein localization to peroxisome (GO:0072662) | 3.12784391 |
| 79 | protein targeting to peroxisome (GO:0006625) | 3.12784391 |
| 80 | establishment of protein localization to peroxisome (GO:0072663) | 3.12784391 |
| 81 | negative regulation of macroautophagy (GO:0016242) | 3.12777878 |
| 82 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.09188812 |
| 83 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.09188812 |
| 84 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.08964238 |
| 85 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.08964238 |
| 86 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.08964238 |
| 87 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.07317359 |
| 88 | ER to Golgi vesicle-mediated transport (GO:0006888) | 2.99505233 |
| 89 | RNA methylation (GO:0001510) | 2.97253873 |
| 90 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 2.97033710 |
| 91 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 2.97033710 |
| 92 | positive regulation of interleukin-1 secretion (GO:0050716) | 2.96170314 |
| 93 | tRNA modification (GO:0006400) | 2.94575892 |
| 94 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 2.94229229 |
| 95 | single-organism membrane fusion (GO:0044801) | 2.92395921 |
| 96 | mitotic recombination (GO:0006312) | 2.91301656 |
| 97 | GPI anchor biosynthetic process (GO:0006506) | 2.90807405 |
| 98 | regulation of autophagic vacuole assembly (GO:2000785) | 2.90061866 |
| 99 | protein prenylation (GO:0018342) | 10.2579416 |
| 100 | prenylation (GO:0097354) | 10.2579416 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 8.52081983 |
| 2 | GATA1_22025678_ChIP-Seq_K562_Human | 6.88762547 |
| 3 | VDR_22108803_ChIP-Seq_LS180_Human | 5.13368617 |
| 4 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.83170262 |
| 5 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.95572805 |
| 6 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 3.71989496 |
| 7 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.97084839 |
| 8 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.87965902 |
| 9 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 2.75153900 |
| 10 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.68416978 |
| 11 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 2.65556214 |
| 12 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.53382572 |
| 13 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 2.49689052 |
| 14 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 2.47820413 |
| 15 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.45589171 |
| 16 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 2.43732002 |
| 17 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.36702736 |
| 18 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.32106790 |
| 19 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.22846901 |
| 20 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.09280153 |
| 21 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 2.09004142 |
| 22 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.08259833 |
| 23 | AR_21572438_ChIP-Seq_LNCaP_Human | 2.04057487 |
| 24 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.90720316 |
| 25 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.76944436 |
| 26 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.72430578 |
| 27 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 1.71060466 |
| 28 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.69487496 |
| 29 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.66472404 |
| 30 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 1.62610859 |
| 31 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.57056181 |
| 32 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.55199475 |
| 33 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.52692544 |
| 34 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.47088399 |
| 35 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.40364954 |
| 36 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.39726392 |
| 37 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.37067247 |
| 38 | BCAT_22108803_ChIP-Seq_LS180_Human | 1.35034849 |
| 39 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.34014736 |
| 40 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.33462293 |
| 41 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.27421248 |
| 42 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.27038808 |
| 43 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.25978144 |
| 44 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.25101074 |
| 45 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.21720291 |
| 46 | GATA3_26560356_Chip-Seq_TH1_Human | 1.20714638 |
| 47 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.19635292 |
| 48 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.19307498 |
| 49 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.16039379 |
| 50 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.13006290 |
| 51 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.10679050 |
| 52 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 1.10679050 |
| 53 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.07503929 |
| 54 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.04876266 |
| 55 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.03706306 |
| 56 | ZIC3_20872845_ChIP-ChIP_MESCs_Mouse | 1.02231669 |
| 57 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 0.97108296 |
| 58 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 0.97108296 |
| 59 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 0.94470156 |
| 60 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 0.93855116 |
| 61 | FUS_26573619_Chip-Seq_HEK293_Human | 0.92297621 |
| 62 | ERG_20517297_ChIP-Seq_VCAP_Human | 0.91799221 |
| 63 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 0.88936258 |
| 64 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 0.88643845 |
| 65 | SOX2_19829295_ChIP-Seq_ESCs_Human | 0.88579996 |
| 66 | NANOG_19829295_ChIP-Seq_ESCs_Human | 0.88579996 |
| 67 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 0.88346240 |
| 68 | P300_19829295_ChIP-Seq_ESCs_Human | 0.87456927 |
| 69 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.87410021 |
| 70 | FOXH1_21741376_ChIP-Seq_EPCs_Human | 0.86245316 |
| 71 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 0.85123485 |
| 72 | CEBPA_26348894_ChIP-Seq_LIVER_Mouse | 0.84432137 |
| 73 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 0.84150944 |
| 74 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 0.82637980 |
| 75 | RXR_22108803_ChIP-Seq_LS180_Human | 0.82604395 |
| 76 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 0.82508125 |
| 77 | NANOG_20526341_ChIP-Seq_ESCs_Human | 0.81618267 |
| 78 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 0.81115200 |
| 79 | TTF2_22483619_ChIP-Seq_HELA_Human | 0.80094601 |
| 80 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 0.80080506 |
| 81 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 0.76752931 |
| 82 | AR_20517297_ChIP-Seq_VCAP_Human | 0.76034945 |
| 83 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 0.75855397 |
| 84 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 0.73324815 |
| 85 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 0.72362587 |
| 86 | STAT1_20625510_ChIP-Seq_HELA_Human | 0.72030046 |
| 87 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 0.71691910 |
| 88 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 0.71526615 |
| 89 | MYC_18940864_ChIP-ChIP_HL60_Human | 0.71050089 |
| 90 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 0.70906784 |
| 91 | WDR5_24793694_ChIP-Seq_LNCAP_Human | 0.69951091 |
| 92 | KAP1_22055183_ChIP-Seq_ESCs_Mouse | 0.69255358 |
| 93 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 0.68349881 |
| 94 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 0.67670720 |
| 95 | FOXH1_21741376_ChIP-Seq_ESCs_Human | 0.67465676 |
| 96 | TCF4_22108803_ChIP-Seq_LS180_Human | 0.66233306 |
| 97 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.66152100 |
| 98 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 0.65634759 |
| 99 | GATA3_21878914_ChIP-Seq_MCF-7_Human | 0.65509638 |
| 100 | NCOR_22424771_ChIP-Seq_293T_Human | 0.65077146 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003303_peritoneal_inflammation | 7.38753727 |
| 2 | MP0006082_CNS_inflammation | 4.90569238 |
| 3 | MP0001919_abnormal_reproductive_system | 3.07925267 |
| 4 | MP0001663_abnormal_digestive_system | 2.95080351 |
| 5 | MP0001664_abnormal_digestion | 2.58021504 |
| 6 | MP0002876_abnormal_thyroid_physiology | 2.57112727 |
| 7 | MP0002751_abnormal_autonomic_nervous | 2.45015859 |
| 8 | MP0000467_abnormal_esophagus_morphology | 2.43227028 |
| 9 | MP0005381_digestive/alimentary_phenotyp | 2.14200562 |
| 10 | MP0005389_reproductive_system_phenotype | 2.13658639 |
| 11 | MP0000383_abnormal_hair_follicle | 2.00120823 |
| 12 | MP0000566_synostosis | 10.5118640 |
| 13 | MP0008058_abnormal_DNA_repair | 1.89858608 |
| 14 | MP0005166_decreased_susceptibility_to | 1.71822807 |
| 15 | MP0003115_abnormal_respiratory_system | 1.69210620 |
| 16 | MP0002102_abnormal_ear_morphology | 1.64605974 |
| 17 | MP0004147_increased_porphyrin_level | 1.63094479 |
| 18 | MP0000372_irregular_coat_pigmentation | 1.57204179 |
| 19 | MP0001764_abnormal_homeostasis | 1.53841277 |
| 20 | MP0003937_abnormal_limbs/digits/tail_de | 1.46494774 |
| 21 | MP0000534_abnormal_ureter_morphology | 1.39315090 |
| 22 | MP0008875_abnormal_xenobiotic_pharmacok | 1.32003672 |
| 23 | MP0005671_abnormal_response_to | 1.31618617 |
| 24 | MP0003763_abnormal_thymus_physiology | 1.30575964 |
| 25 | MP0005360_urolithiasis | 1.27003488 |
| 26 | MP0000490_abnormal_crypts_of | 1.19084316 |
| 27 | MP0008872_abnormal_physiological_respon | 1.16474609 |
| 28 | MP0003718_maternal_effect | 1.14807950 |
| 29 | MP0001293_anophthalmia | 1.11393681 |
| 30 | MP0006292_abnormal_olfactory_placode | 1.11001854 |
| 31 | MP0005645_abnormal_hypothalamus_physiol | 1.07865671 |
| 32 | MP0003806_abnormal_nucleotide_metabolis | 1.07385427 |
| 33 | MP0001529_abnormal_vocalization | 1.05188452 |
| 34 | MP0005253_abnormal_eye_physiology | 1.02757632 |
| 35 | MP0010678_abnormal_skin_adnexa | 1.02320228 |
| 36 | MP0003646_muscle_fatigue | 1.00542132 |
| 37 | MP0001873_stomach_inflammation | 0.99426972 |
| 38 | MP0002938_white_spotting | 0.98691744 |
| 39 | MP0010155_abnormal_intestine_physiology | 0.98683807 |
| 40 | MP0002019_abnormal_tumor_incidence | 0.98620205 |
| 41 | MP0001286_abnormal_eye_development | 0.97390306 |
| 42 | MP0001915_intracranial_hemorrhage | 0.95784515 |
| 43 | MP0009785_altered_susceptibility_to | 0.95328056 |
| 44 | MP0002210_abnormal_sex_determination | 0.93224240 |
| 45 | MP0001963_abnormal_hearing_physiology | 0.92648157 |
| 46 | MP0006276_abnormal_autonomic_nervous | 0.91049117 |
| 47 | MP0005646_abnormal_pituitary_gland | 0.89324150 |
| 48 | MP0005085_abnormal_gallbladder_physiolo | 0.87685106 |
| 49 | MP0005332_abnormal_amino_acid | 0.87317202 |
| 50 | MP0000026_abnormal_inner_ear | 0.87258789 |
| 51 | MP0000358_abnormal_cell_content/ | 0.83570396 |
| 52 | MP0003195_calcinosis | 0.83015088 |
| 53 | MP0006072_abnormal_retinal_apoptosis | 0.77794138 |
| 54 | MP0001485_abnormal_pinna_reflex | 0.77480030 |
| 55 | MP0001905_abnormal_dopamine_level | 0.77284463 |
| 56 | MP0005501_abnormal_skin_physiology | 0.77036341 |
| 57 | MP0004145_abnormal_muscle_electrophysio | 0.76202909 |
| 58 | MP0002736_abnormal_nociception_after | 0.76080688 |
| 59 | MP0005084_abnormal_gallbladder_morpholo | 0.75468122 |
| 60 | MP0002277_abnormal_respiratory_mucosa | 0.74878406 |
| 61 | MP0003077_abnormal_cell_cycle | 0.72847876 |
| 62 | MP0005551_abnormal_eye_electrophysiolog | 0.71815861 |
| 63 | MP0002138_abnormal_hepatobiliary_system | 0.71799375 |
| 64 | MP0002109_abnormal_limb_morphology | 0.70934052 |
| 65 | MP0003693_abnormal_embryo_hatching | 0.70262886 |
| 66 | MP0001800_abnormal_humoral_immune | 0.70093928 |
| 67 | MP0009763_increased_sensitivity_to | 0.69949329 |
| 68 | MP0001835_abnormal_antigen_presentation | 0.68898615 |
| 69 | MP0002822_catalepsy | 0.65585689 |
| 70 | MP0002405_respiratory_system_inflammati | 0.65443064 |
| 71 | MP0005395_other_phenotype | 0.62362763 |
| 72 | MP0003786_premature_aging | 0.61143296 |
| 73 | MP0005410_abnormal_fertilization | 0.60572322 |
| 74 | MP0002184_abnormal_innervation | 0.60067150 |
| 75 | MP0003878_abnormal_ear_physiology | 0.58772813 |
| 76 | MP0005377_hearing/vestibular/ear_phenot | 0.58772813 |
| 77 | MP0001986_abnormal_taste_sensitivity | 0.58582709 |
| 78 | MP0003011_delayed_dark_adaptation | 0.58389786 |
| 79 | MP0004142_abnormal_muscle_tone | 0.58375438 |
| 80 | MP0003942_abnormal_urinary_system | 0.56994437 |
| 81 | MP0002837_dystrophic_cardiac_calcinosis | 0.56134747 |
| 82 | MP0005025_abnormal_response_to | 0.54942917 |
| 83 | MP0000428_abnormal_craniofacial_morphol | 0.54924324 |
| 84 | MP0010094_abnormal_chromosome_stability | 0.54253597 |
| 85 | MP0001790_abnormal_immune_system | 0.54251712 |
| 86 | MP0005387_immune_system_phenotype | 0.54251712 |
| 87 | MP0002148_abnormal_hypersensitivity_rea | 0.53225198 |
| 88 | MP0002115_abnormal_skeleton_extremities | 0.52522177 |
| 89 | MP0001929_abnormal_gametogenesis | 0.51547861 |
| 90 | MP0009764_decreased_sensitivity_to | 0.51028624 |
| 91 | MP0002452_abnormal_antigen_presenting | 0.50932680 |
| 92 | MP0003638_abnormal_response/metabolism_ | 0.50748800 |
| 93 | MP0000477_abnormal_intestine_morphology | 0.50423917 |
| 94 | MP0000470_abnormal_stomach_morphology | 0.49056163 |
| 95 | MP0005075_abnormal_melanosome_morpholog | 0.48539438 |
| 96 | MP0005167_abnormal_blood-brain_barrier | 0.47745879 |
| 97 | MP0001666_abnormal_nutrient_absorption | 0.47646218 |
| 98 | MP0009333_abnormal_splenocyte_physiolog | 0.47205979 |
| 99 | MP0010386_abnormal_urinary_bladder | 0.46809438 |
| 100 | MP0008877_abnormal_DNA_methylation | 0.46446295 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Abnormality of long-chain fatty-acid metabolism (HP:0010964) | 8.82993373 |
| 2 | Duplicated collecting system (HP:0000081) | 7.07958663 |
| 3 | Abnormality of the renal collecting system (HP:0004742) | 6.45476996 |
| 4 | Long foot (HP:0001833) | 5.95263917 |
| 5 | Abnormality of fatty-acid metabolism (HP:0004359) | 5.46365351 |
| 6 | Large for gestational age (HP:0001520) | 5.39004732 |
| 7 | Adactyly (HP:0009776) | 5.06588033 |
| 8 | Progressive muscle weakness (HP:0003323) | 4.53092832 |
| 9 | Hypoplastic pelvis (HP:0008839) | 4.51727930 |
| 10 | Dry hair (HP:0011359) | 4.30143528 |
| 11 | Acute lymphatic leukemia (HP:0006721) | 4.27055717 |
| 12 | Ureteral stenosis (HP:0000071) | 4.17897581 |
| 13 | Autoamputation (HP:0001218) | 4.16155533 |
| 14 | Ureteral obstruction (HP:0006000) | 3.88506856 |
| 15 | Ureteral duplication (HP:0000073) | 3.82235014 |
| 16 | Reduced subcutaneous adipose tissue (HP:0003758) | 3.78207299 |
| 17 | Brushfield spots (HP:0001088) | 3.77687299 |
| 18 | Acute necrotizing encephalopathy (HP:0006965) | 3.72644123 |
| 19 | Steatorrhea (HP:0002570) | 3.49941450 |
| 20 | Lactic acidosis (HP:0003128) | 3.39256125 |
| 21 | Acute encephalopathy (HP:0006846) | 3.26745986 |
| 22 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.26654821 |
| 23 | Pulmonary artery stenosis (HP:0004415) | 3.24408687 |
| 24 | Mitochondrial inheritance (HP:0001427) | 3.22454155 |
| 25 | 3-Methylglutaconic aciduria (HP:0003535) | 3.21646758 |
| 26 | Menstrual irregularities (HP:0000858) | 3.09209081 |
| 27 | Hepatocellular necrosis (HP:0001404) | 3.06347766 |
| 28 | Broad-based gait (HP:0002136) | 3.05411935 |
| 29 | Progressive macrocephaly (HP:0004481) | 3.04853558 |
| 30 | Hypoplastic nipples (HP:0002557) | 3.04064152 |
| 31 | Severe muscular hypotonia (HP:0006829) | 2.96657310 |
| 32 | Increased serum lactate (HP:0002151) | 2.96619785 |
| 33 | Fat malabsorption (HP:0002630) | 2.92584291 |
| 34 | Abnormal auditory evoked potentials (HP:0006958) | 2.90729356 |
| 35 | Increased CSF lactate (HP:0002490) | 2.89179415 |
| 36 | Hepatic necrosis (HP:0002605) | 2.79147000 |
| 37 | Clubbing of toes (HP:0100760) | 2.76458846 |
| 38 | Anhidrosis (HP:0000970) | 2.76065589 |
| 39 | Polyneuropathy (HP:0001271) | 2.64491743 |
| 40 | Decreased muscle mass (HP:0003199) | 2.62968805 |
| 41 | Exercise intolerance (HP:0003546) | 2.59249072 |
| 42 | Increased hepatocellular lipid droplets (HP:0006565) | 2.57013816 |
| 43 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.56235351 |
| 44 | Wide intermamillary distance (HP:0006610) | 2.52167495 |
| 45 | Epiphyseal stippling (HP:0010655) | 2.51865740 |
| 46 | Renal Fanconi syndrome (HP:0001994) | 2.43978869 |
| 47 | Cerebral edema (HP:0002181) | 2.43852928 |
| 48 | Polymicrogyria (HP:0002126) | 2.42876288 |
| 49 | Sudden death (HP:0001699) | 2.42184659 |
| 50 | Lipid accumulation in hepatocytes (HP:0006561) | 2.41574263 |
| 51 | Respiratory failure (HP:0002878) | 2.41177867 |
| 52 | Transposition of the great arteries (HP:0001669) | 2.40730450 |
| 53 | Abnormal connection of the cardiac segments (HP:0011545) | 2.40730450 |
| 54 | Abnormal ventriculo-arterial connection (HP:0011563) | 2.40730450 |
| 55 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.39766477 |
| 56 | Abnormality of alanine metabolism (HP:0010916) | 2.39766477 |
| 57 | Hyperalaninemia (HP:0003348) | 2.39766477 |
| 58 | CNS demyelination (HP:0007305) | 2.37027567 |
| 59 | Increased number of teeth (HP:0011069) | 2.32781674 |
| 60 | Metabolic acidosis (HP:0001942) | 2.21152989 |
| 61 | Decreased lacrimation (HP:0000633) | 2.16963399 |
| 62 | Myoglobinuria (HP:0002913) | 2.16934069 |
| 63 | Chorioretinal coloboma (HP:0000567) | 2.15460411 |
| 64 | Palmoplantar hyperkeratosis (HP:0000972) | 2.13605548 |
| 65 | Rhabdomyolysis (HP:0003201) | 2.06930885 |
| 66 | Palmar hyperkeratosis (HP:0010765) | 2.02699232 |
| 67 | Flat face (HP:0012368) | 1.93990028 |
| 68 | Hyperammonemia (HP:0001987) | 1.92015665 |
| 69 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 1.90365724 |
| 70 | Female pseudohermaphroditism (HP:0010458) | 1.87389092 |
| 71 | Optic disc pallor (HP:0000543) | 1.86255336 |
| 72 | Generalized aminoaciduria (HP:0002909) | 1.85969161 |
| 73 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 1.83906113 |
| 74 | Lethargy (HP:0001254) | 1.79287670 |
| 75 | Anxiety (HP:0000739) | 1.77930359 |
| 76 | Congenital, generalized hypertrichosis (HP:0004540) | 1.77018193 |
| 77 | Spastic tetraplegia (HP:0002510) | 1.76235931 |
| 78 | Abnormality of vision evoked potentials (HP:0000649) | 1.74971114 |
| 79 | Large hands (HP:0001176) | 1.73263288 |
| 80 | Gangrene (HP:0100758) | 1.73257024 |
| 81 | Abnormal epiphyseal ossification (HP:0010656) | 1.72460677 |
| 82 | Congenital stationary night blindness (HP:0007642) | 1.71215647 |
| 83 | Widely spaced teeth (HP:0000687) | 1.70235865 |
| 84 | Exertional dyspnea (HP:0002875) | 1.69720797 |
| 85 | Increased intramyocellular lipid droplets (HP:0012240) | 1.68719638 |
| 86 | Glycosuria (HP:0003076) | 1.64874525 |
| 87 | Abnormality of urine glucose concentration (HP:0011016) | 1.64874525 |
| 88 | Congenital onset (HP:0003577) | 1.63674730 |
| 89 | Hypothermia (HP:0002045) | 1.63673675 |
| 90 | Plantar hyperkeratosis (HP:0007556) | 1.62965384 |
| 91 | Aplasia/Hypoplasia of the nipples (HP:0006709) | 1.61121862 |
| 92 | Aplastic anemia (HP:0001915) | 1.60358519 |
| 93 | Methylmalonic aciduria (HP:0012120) | 1.60247305 |
| 94 | Abnormality of renal resorption (HP:0011038) | 1.58361247 |
| 95 | Postnatal microcephaly (HP:0005484) | 1.58203875 |
| 96 | Retinopathy (HP:0000488) | 1.57884400 |
| 97 | Constricted visual fields (HP:0001133) | 1.56355999 |
| 98 | Generalized amyotrophy (HP:0003700) | 1.56035808 |
| 99 | Overfolded helix (HP:0000396) | 1.54933589 |
| 100 | Hypoplastic iliac wings (HP:0002866) | 1.51623412 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MKNK1 | 6.41846767 |
| 2 | TAOK1 | 5.20174417 |
| 3 | TAOK2 | 4.69201198 |
| 4 | MAP3K3 | 3.68131171 |
| 5 | MAP3K11 | 3.48557168 |
| 6 | MAP2K3 | 3.31638445 |
| 7 | JAK3 | 2.07927319 |
| 8 | MKNK2 | 10.6405215 |
| 9 | SRPK1 | 1.86171220 |
| 10 | ABL2 | 1.71671010 |
| 11 | VRK2 | 1.70057824 |
| 12 | DYRK1A | 1.47407217 |
| 13 | TXK | 1.31953630 |
| 14 | MAP3K5 | 1.25512075 |
| 15 | ZAK | 1.22980972 |
| 16 | TLK1 | 1.00772581 |
| 17 | VRK1 | 0.94977342 |
| 18 | TSSK6 | 0.89227823 |
| 19 | CHEK2 | 0.85221455 |
| 20 | NUAK1 | 0.84514616 |
| 21 | BUB1 | 0.84334495 |
| 22 | TIE1 | 0.83485368 |
| 23 | NEK1 | 0.82914742 |
| 24 | MAP4K2 | 0.75229570 |
| 25 | TRIM28 | 0.73943594 |
| 26 | GRK1 | 0.72640525 |
| 27 | ADRBK2 | 0.68400682 |
| 28 | CCNB1 | 0.65888789 |
| 29 | PRKCQ | 0.65261214 |
| 30 | BMPR1B | 0.64606362 |
| 31 | MST4 | 0.64161826 |
| 32 | MAP3K1 | 0.55016649 |
| 33 | EIF2AK3 | 0.51838325 |
| 34 | INSRR | 0.50748539 |
| 35 | NME1 | 0.50109494 |
| 36 | EIF2AK1 | 0.49350961 |
| 37 | FRK | 0.49341190 |
| 38 | PLK3 | 0.47958655 |
| 39 | MAP3K8 | 0.46360883 |
| 40 | PBK | 0.46309554 |
| 41 | WNK3 | 0.46080773 |
| 42 | CDC7 | 0.41717944 |
| 43 | TAF1 | 0.41673195 |
| 44 | WNK4 | 0.41230743 |
| 45 | BCKDK | 0.40851889 |
| 46 | PDK2 | 0.40235071 |
| 47 | STK39 | 0.38319789 |
| 48 | CSNK1G3 | 0.37177988 |
| 49 | PLK4 | 0.33140464 |
| 50 | CSNK1A1 | 0.32969118 |
| 51 | OXSR1 | 0.31528894 |
| 52 | KDR | 0.31026330 |
| 53 | MAP2K7 | 0.30760670 |
| 54 | TEC | 0.26893436 |
| 55 | CSNK1G2 | 0.26060596 |
| 56 | CSNK1A1L | 0.25993315 |
| 57 | CSNK1G1 | 0.25709651 |
| 58 | OBSCN | 0.24234119 |
| 59 | DYRK2 | 0.23561040 |
| 60 | GRK5 | 0.22999195 |
| 61 | CSNK2A2 | 0.22923529 |
| 62 | AURKA | 0.22103851 |
| 63 | CSNK2A1 | 0.21727364 |
| 64 | IGF1R | 0.20167720 |
| 65 | ACVR1B | 0.19629423 |
| 66 | PLK2 | 0.18327780 |
| 67 | PHKG2 | 0.16074403 |
| 68 | PHKG1 | 0.16074403 |
| 69 | MAP2K6 | 0.15374072 |
| 70 | AURKB | 0.15265754 |
| 71 | MAP4K1 | 0.14667830 |
| 72 | EIF2AK2 | 0.14311697 |
| 73 | STK16 | 0.14208310 |
| 74 | FES | 0.13687260 |
| 75 | TGFBR2 | 0.12893185 |
| 76 | PRKCD | 0.12028558 |
| 77 | CSNK1E | 0.11461311 |
| 78 | ABL1 | 0.11048536 |
| 79 | RPS6KA5 | 0.10508792 |
| 80 | BCR | 0.10452155 |
| 81 | PRKCA | 0.10187573 |
| 82 | MAP3K4 | 0.09780432 |
| 83 | ADRBK1 | 0.09516381 |
| 84 | PLK1 | 0.09504143 |
| 85 | MYLK | 0.09487673 |
| 86 | STK38L | 0.09135125 |
| 87 | MAP3K12 | 0.09092357 |
| 88 | MATK | 0.08395683 |
| 89 | ITK | 0.07885178 |
| 90 | PIM2 | 0.07852058 |
| 91 | IKBKB | 0.07626619 |
| 92 | ATR | 0.07566790 |
| 93 | DAPK1 | 0.07108210 |
| 94 | PRKACA | 0.06618791 |
| 95 | KIT | 0.06544317 |
| 96 | MUSK | 0.05313097 |
| 97 | PRKCG | 0.04925836 |
| 98 | MAPK13 | 0.04904363 |
| 99 | GRK7 | 0.03825454 |
| 100 | PRKCB | 0.03686416 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 4.99391339 |
| 2 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 4.35491280 |
| 3 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 3.79412382 |
| 4 | RNA polymerase_Homo sapiens_hsa03020 | 3.53741016 |
| 5 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 2.84256485 |
| 6 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.55736087 |
| 7 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 2.48360327 |
| 8 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.48330972 |
| 9 | Parkinsons disease_Homo sapiens_hsa05012 | 2.03574374 |
| 10 | Butanoate metabolism_Homo sapiens_hsa00650 | 2.03032212 |
| 11 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.83987518 |
| 12 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.81672775 |
| 13 | Protein export_Homo sapiens_hsa03060 | 1.70192773 |
| 14 | Huntingtons disease_Homo sapiens_hsa05016 | 1.66171825 |
| 15 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.60288796 |
| 16 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.58901334 |
| 17 | Taste transduction_Homo sapiens_hsa04742 | 1.49037024 |
| 18 | Tryptophan metabolism_Homo sapiens_hsa00380 | 1.48143727 |
| 19 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.47366238 |
| 20 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.36386200 |
| 21 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 1.34165601 |
| 22 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.32849795 |
| 23 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.30223384 |
| 24 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 1.30029442 |
| 25 | Ribosome_Homo sapiens_hsa03010 | 1.28745986 |
| 26 | Asthma_Homo sapiens_hsa05310 | 1.26664704 |
| 27 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.24149639 |
| 28 | Alzheimers disease_Homo sapiens_hsa05010 | 1.22905624 |
| 29 | Peroxisome_Homo sapiens_hsa04146 | 1.22317009 |
| 30 | RNA transport_Homo sapiens_hsa03013 | 1.13938981 |
| 31 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.13214614 |
| 32 | Homologous recombination_Homo sapiens_hsa03440 | 1.11556948 |
| 33 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 1.11312604 |
| 34 | Allograft rejection_Homo sapiens_hsa05330 | 1.11201537 |
| 35 | Purine metabolism_Homo sapiens_hsa00230 | 1.07184544 |
| 36 | DNA replication_Homo sapiens_hsa03030 | 1.06720271 |
| 37 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.05438756 |
| 38 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.04289357 |
| 39 | Mismatch repair_Homo sapiens_hsa03430 | 1.00817859 |
| 40 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.97698642 |
| 41 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.97442126 |
| 42 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.96715895 |
| 43 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.96512661 |
| 44 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.96015875 |
| 45 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.95964419 |
| 46 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.93611274 |
| 47 | Sulfur relay system_Homo sapiens_hsa04122 | 0.91945792 |
| 48 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.90817054 |
| 49 | Base excision repair_Homo sapiens_hsa03410 | 0.90814560 |
| 50 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.87026825 |
| 51 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.83078592 |
| 52 | Lysine degradation_Homo sapiens_hsa00310 | 0.81310118 |
| 53 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.79213827 |
| 54 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.79058329 |
| 55 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.76069836 |
| 56 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.75717136 |
| 57 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.74485414 |
| 58 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.74132007 |
| 59 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.73273774 |
| 60 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.72628913 |
| 61 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.71161898 |
| 62 | Metabolic pathways_Homo sapiens_hsa01100 | 0.69966665 |
| 63 | Phototransduction_Homo sapiens_hsa04744 | 0.69818473 |
| 64 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.69184684 |
| 65 | RNA degradation_Homo sapiens_hsa03018 | 0.66611984 |
| 66 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.63786795 |
| 67 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.62615121 |
| 68 | Retinol metabolism_Homo sapiens_hsa00830 | 0.62472992 |
| 69 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.60729763 |
| 70 | Viral myocarditis_Homo sapiens_hsa05416 | 0.60192656 |
| 71 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.59289920 |
| 72 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.58251037 |
| 73 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.55982180 |
| 74 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.55898140 |
| 75 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.55780027 |
| 76 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.55422272 |
| 77 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.54117516 |
| 78 | Basal transcription factors_Homo sapiens_hsa03022 | 0.53821096 |
| 79 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.53622309 |
| 80 | Spliceosome_Homo sapiens_hsa03040 | 0.53241748 |
| 81 | Carbon metabolism_Homo sapiens_hsa01200 | 0.52752943 |
| 82 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.51699097 |
| 83 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.51438206 |
| 84 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.51355607 |
| 85 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.47783413 |
| 86 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.47714699 |
| 87 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.47503181 |
| 88 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.46834912 |
| 89 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.44065916 |
| 90 | Olfactory transduction_Homo sapiens_hsa04740 | 0.43868505 |
| 91 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.43057919 |
| 92 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.42433854 |
| 93 | Nicotine addiction_Homo sapiens_hsa05033 | 0.42024473 |
| 94 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.39075740 |
| 95 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.39035563 |
| 96 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.37852565 |
| 97 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.36906962 |
| 98 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.36457623 |
| 99 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.36249907 |
| 100 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.35276913 |

