GAPDHP61

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of mitotic sister chromatid separation (GO:1901970)8.98028897
2positive regulation of mitotic metaphase/anaphase transition (GO:0045842)8.98028897
3positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)8.98028897
4negative regulation of Ras GTPase activity (GO:0034261)8.92008262
5eosinophil chemotaxis (GO:0048245)8.69771265
6negative regulation of T cell receptor signaling pathway (GO:0050860)8.18434324
7eosinophil migration (GO:0072677)7.85574510
8regulation of sister chromatid cohesion (GO:0007063)7.75062714
9ribosomal small subunit assembly (GO:0000028)7.57757775
10L-fucose metabolic process (GO:0042354)7.44852932
11L-fucose catabolic process (GO:0042355)7.44852932
12fucose catabolic process (GO:0019317)7.44852932
13regulation of mononuclear cell migration (GO:0071675)6.74734970
14negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)6.36904675
15coenzyme A biosynthetic process (GO:0015937)6.17090008
16negative regulation of peptidyl-threonine phosphorylation (GO:0010801)6.11778565
17branch elongation of an epithelium (GO:0060602)6.01581918
18positive regulation of chromosome segregation (GO:0051984)5.89035026
19proteasome assembly (GO:0043248)5.61827792
20vesicle fusion (GO:0006906)5.48234485
21autophagic vacuole fusion (GO:0000046)5.29219166
22negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)5.25125210
23macrophage chemotaxis (GO:0048246)5.16558950
24double-strand break repair via nonhomologous end joining (GO:0006303)5.06989887
25non-recombinational repair (GO:0000726)5.06989887
26regulation of T cell receptor signaling pathway (GO:0050856)5.03572496
27peptidyl-lysine dimethylation (GO:0018027)4.60738171
28organ growth (GO:0035265)4.53657789
29organelle membrane fusion (GO:0090174)4.48470459
30localization within membrane (GO:0051668)4.47842224
31protein import into peroxisome matrix (GO:0016558)4.47435261
32positive regulation of calcium ion import (GO:0090280)4.34798483
33iron-sulfur cluster assembly (GO:0016226)4.30236040
34metallo-sulfur cluster assembly (GO:0031163)4.30236040
35monocyte chemotaxis (GO:0002548)4.28772794
36DNA integration (GO:0015074)4.21455059
37regulation of nitric-oxide synthase biosynthetic process (GO:0051769)4.11612455
38acrosome assembly (GO:0001675)4.09183705
39establishment of mitotic spindle orientation (GO:0000132)4.03323298
40axis elongation (GO:0003401)3.99171198
41purine nucleoside bisphosphate biosynthetic process (GO:0034033)3.99138658
42ribonucleoside bisphosphate biosynthetic process (GO:0034030)3.99138658
43nucleoside bisphosphate biosynthetic process (GO:0033866)3.99138658
44pantothenate metabolic process (GO:0015939)3.99055993
45fucose metabolic process (GO:0006004)3.98801138
46DNA demethylation (GO:0080111)3.95837894
47folic acid-containing compound biosynthetic process (GO:0009396)3.91538308
48fucosylation (GO:0036065)3.84204878
49detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)3.79877176
50preassembly of GPI anchor in ER membrane (GO:0016254)3.77622071
51seminiferous tubule development (GO:0072520)3.76639640
52negative regulation of GTP catabolic process (GO:0033125)3.71860794
53negative regulation of GTPase activity (GO:0034260)3.71860794
54establishment of mitotic spindle localization (GO:0040001)3.66582274
55coenzyme A metabolic process (GO:0015936)3.62710833
56oxidative demethylation (GO:0070989)3.60652324
57mitochondrial RNA metabolic process (GO:0000959)3.60206046
58regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.52194905
59organelle fusion (GO:0048284)3.51545475
60regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.51108333
61telomere maintenance via recombination (GO:0000722)3.46835777
62DNA dealkylation (GO:0035510)3.39676007
63regulation of cellular amino acid metabolic process (GO:0006521)3.37859832
64transcription elongation from RNA polymerase III promoter (GO:0006385)3.35394903
65termination of RNA polymerase III transcription (GO:0006386)3.35394903
66establishment of spindle orientation (GO:0051294)3.30789168
67positive chemotaxis (GO:0050918)3.27590004
68detection of chemical stimulus involved in sensory perception of taste (GO:0050912)3.22717085
69cytidine deamination (GO:0009972)3.19110632
70cytidine metabolic process (GO:0046087)3.19110632
71cytidine catabolic process (GO:0006216)3.19110632
72intracellular protein transmembrane import (GO:0044743)3.17960706
73DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.17586386
74DNA deamination (GO:0045006)3.16689106
75regulation of beta-amyloid formation (GO:1902003)3.16662079
76positive regulation of interleukin-1 beta secretion (GO:0050718)3.16102931
77negative regulation of circadian rhythm (GO:0042754)3.15483923
78protein localization to peroxisome (GO:0072662)3.12784391
79protein targeting to peroxisome (GO:0006625)3.12784391
80establishment of protein localization to peroxisome (GO:0072663)3.12784391
81negative regulation of macroautophagy (GO:0016242)3.12777878
82signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.09188812
83intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.09188812
84signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.08964238
85signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.08964238
86signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.08964238
87negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.07317359
88ER to Golgi vesicle-mediated transport (GO:0006888)2.99505233
89RNA methylation (GO:0001510)2.97253873
90signal transduction involved in DNA integrity checkpoint (GO:0072401)2.97033710
91signal transduction involved in DNA damage checkpoint (GO:0072422)2.97033710
92positive regulation of interleukin-1 secretion (GO:0050716)2.96170314
93tRNA modification (GO:0006400)2.94575892
94signal transduction involved in cell cycle checkpoint (GO:0072395)2.94229229
95single-organism membrane fusion (GO:0044801)2.92395921
96mitotic recombination (GO:0006312)2.91301656
97GPI anchor biosynthetic process (GO:0006506)2.90807405
98regulation of autophagic vacuole assembly (GO:2000785)2.90061866
99protein prenylation (GO:0018342)10.2579416
100prenylation (GO:0097354)10.2579416

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse8.52081983
2GATA1_22025678_ChIP-Seq_K562_Human6.88762547
3VDR_22108803_ChIP-Seq_LS180_Human5.13368617
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.83170262
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.95572805
6NOTCH1_21737748_ChIP-Seq_TLL_Human3.71989496
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.97084839
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.87965902
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.75153900
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.68416978
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.65556214
12CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.53382572
13RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.49689052
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.47820413
15SRF_21415370_ChIP-Seq_HL-1_Mouse2.45589171
16YY1_21170310_ChIP-Seq_MESCs_Mouse2.43732002
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.36702736
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.32106790
19MYC_18555785_ChIP-Seq_MESCs_Mouse2.22846901
20VDR_23849224_ChIP-Seq_CD4+_Human2.09280153
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.09004142
22ZNF274_21170338_ChIP-Seq_K562_Hela2.08259833
23AR_21572438_ChIP-Seq_LNCaP_Human2.04057487
24PCGF2_27294783_Chip-Seq_ESCs_Mouse1.90720316
25FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.76944436
26IRF1_19129219_ChIP-ChIP_H3396_Human1.72430578
27PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.71060466
28CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.69487496
29SRY_22984422_ChIP-ChIP_TESTIS_Rat1.66472404
30CREB1_15753290_ChIP-ChIP_HEK293T_Human1.62610859
31ELK1_19687146_ChIP-ChIP_HELA_Human1.57056181
32FOXP3_21729870_ChIP-Seq_TREG_Human1.55199475
33E2F4_17652178_ChIP-ChIP_JURKAT_Human1.52692544
34PCGF2_27294783_Chip-Seq_NPCs_Mouse1.47088399
35ZNF263_19887448_ChIP-Seq_K562_Human1.40364954
36MYC_18358816_ChIP-ChIP_MESCs_Mouse1.39726392
37GABP_19822575_ChIP-Seq_HepG2_Human1.37067247
38BCAT_22108803_ChIP-Seq_LS180_Human1.35034849
39HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.34014736
40THAP11_20581084_ChIP-Seq_MESCs_Mouse1.33462293
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.27421248
42HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.27038808
43POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.25978144
44DCP1A_22483619_ChIP-Seq_HELA_Human1.25101074
45FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.21720291
46GATA3_26560356_Chip-Seq_TH1_Human1.20714638
47MYC_19030024_ChIP-ChIP_MESCs_Mouse1.19635292
48TP53_22573176_ChIP-Seq_HFKS_Human1.19307498
49SUZ12_27294783_Chip-Seq_NPCs_Mouse1.16039379
50NFE2_27457419_Chip-Seq_LIVER_Mouse1.13006290
51TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10679050
52POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10679050
53TAF15_26573619_Chip-Seq_HEK293_Human1.07503929
54E2F1_18555785_ChIP-Seq_MESCs_Mouse1.04876266
55ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.03706306
56ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.02231669
57FOXA1_27270436_Chip-Seq_PROSTATE_Human0.97108296
58FOXA1_25329375_ChIP-Seq_VCAP_Human0.97108296
59EGR1_23403033_ChIP-Seq_LIVER_Mouse0.94470156
60CTBP1_25329375_ChIP-Seq_LNCAP_Human0.93855116
61FUS_26573619_Chip-Seq_HEK293_Human0.92297621
62ERG_20517297_ChIP-Seq_VCAP_Human0.91799221
63MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.88936258
64GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.88643845
65SOX2_19829295_ChIP-Seq_ESCs_Human0.88579996
66NANOG_19829295_ChIP-Seq_ESCs_Human0.88579996
67PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.88346240
68P300_19829295_ChIP-Seq_ESCs_Human0.87456927
69FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.87410021
70FOXH1_21741376_ChIP-Seq_EPCs_Human0.86245316
71POU5F1_16153702_ChIP-ChIP_HESCs_Human0.85123485
72CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.84432137
73STAT3_1855785_ChIP-Seq_MESCs_Mouse0.84150944
74SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.82637980
75RXR_22108803_ChIP-Seq_LS180_Human0.82604395
76ZFP57_27257070_Chip-Seq_ESCs_Mouse0.82508125
77NANOG_20526341_ChIP-Seq_ESCs_Human0.81618267
78HOXB4_20404135_ChIP-ChIP_EML_Mouse0.81115200
79TTF2_22483619_ChIP-Seq_HELA_Human0.80094601
80ELK1_22589737_ChIP-Seq_MCF10A_Human0.80080506
81YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.76752931
82AR_20517297_ChIP-Seq_VCAP_Human0.76034945
83P53_22127205_ChIP-Seq_FIBROBLAST_Human0.75855397
84BP1_19119308_ChIP-ChIP_Hs578T_Human0.73324815
85KLF5_20875108_ChIP-Seq_MESCs_Mouse0.72362587
86STAT1_20625510_ChIP-Seq_HELA_Human0.72030046
87IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.71691910
88EZH2_27294783_Chip-Seq_NPCs_Mouse0.71526615
89MYC_18940864_ChIP-ChIP_HL60_Human0.71050089
90IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.70906784
91WDR5_24793694_ChIP-Seq_LNCAP_Human0.69951091
92KAP1_22055183_ChIP-Seq_ESCs_Mouse0.69255358
93TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.68349881
94EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.67670720
95FOXH1_21741376_ChIP-Seq_ESCs_Human0.67465676
96TCF4_22108803_ChIP-Seq_LS180_Human0.66233306
97CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.66152100
98CRX_20693478_ChIP-Seq_RETINA_Mouse0.65634759
99GATA3_21878914_ChIP-Seq_MCF-7_Human0.65509638
100NCOR_22424771_ChIP-Seq_293T_Human0.65077146

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation7.38753727
2MP0006082_CNS_inflammation4.90569238
3MP0001919_abnormal_reproductive_system3.07925267
4MP0001663_abnormal_digestive_system2.95080351
5MP0001664_abnormal_digestion2.58021504
6MP0002876_abnormal_thyroid_physiology2.57112727
7MP0002751_abnormal_autonomic_nervous2.45015859
8MP0000467_abnormal_esophagus_morphology2.43227028
9MP0005381_digestive/alimentary_phenotyp2.14200562
10MP0005389_reproductive_system_phenotype2.13658639
11MP0000383_abnormal_hair_follicle2.00120823
12MP0000566_synostosis10.5118640
13MP0008058_abnormal_DNA_repair1.89858608
14MP0005166_decreased_susceptibility_to1.71822807
15MP0003115_abnormal_respiratory_system1.69210620
16MP0002102_abnormal_ear_morphology1.64605974
17MP0004147_increased_porphyrin_level1.63094479
18MP0000372_irregular_coat_pigmentation1.57204179
19MP0001764_abnormal_homeostasis1.53841277
20MP0003937_abnormal_limbs/digits/tail_de1.46494774
21MP0000534_abnormal_ureter_morphology1.39315090
22MP0008875_abnormal_xenobiotic_pharmacok1.32003672
23MP0005671_abnormal_response_to1.31618617
24MP0003763_abnormal_thymus_physiology1.30575964
25MP0005360_urolithiasis1.27003488
26MP0000490_abnormal_crypts_of1.19084316
27MP0008872_abnormal_physiological_respon1.16474609
28MP0003718_maternal_effect1.14807950
29MP0001293_anophthalmia1.11393681
30MP0006292_abnormal_olfactory_placode1.11001854
31MP0005645_abnormal_hypothalamus_physiol1.07865671
32MP0003806_abnormal_nucleotide_metabolis1.07385427
33MP0001529_abnormal_vocalization1.05188452
34MP0005253_abnormal_eye_physiology1.02757632
35MP0010678_abnormal_skin_adnexa1.02320228
36MP0003646_muscle_fatigue1.00542132
37MP0001873_stomach_inflammation0.99426972
38MP0002938_white_spotting0.98691744
39MP0010155_abnormal_intestine_physiology0.98683807
40MP0002019_abnormal_tumor_incidence0.98620205
41MP0001286_abnormal_eye_development0.97390306
42MP0001915_intracranial_hemorrhage0.95784515
43MP0009785_altered_susceptibility_to0.95328056
44MP0002210_abnormal_sex_determination0.93224240
45MP0001963_abnormal_hearing_physiology0.92648157
46MP0006276_abnormal_autonomic_nervous0.91049117
47MP0005646_abnormal_pituitary_gland0.89324150
48MP0005085_abnormal_gallbladder_physiolo0.87685106
49MP0005332_abnormal_amino_acid0.87317202
50MP0000026_abnormal_inner_ear0.87258789
51MP0000358_abnormal_cell_content/0.83570396
52MP0003195_calcinosis0.83015088
53MP0006072_abnormal_retinal_apoptosis0.77794138
54MP0001485_abnormal_pinna_reflex0.77480030
55MP0001905_abnormal_dopamine_level0.77284463
56MP0005501_abnormal_skin_physiology0.77036341
57MP0004145_abnormal_muscle_electrophysio0.76202909
58MP0002736_abnormal_nociception_after0.76080688
59MP0005084_abnormal_gallbladder_morpholo0.75468122
60MP0002277_abnormal_respiratory_mucosa0.74878406
61MP0003077_abnormal_cell_cycle0.72847876
62MP0005551_abnormal_eye_electrophysiolog0.71815861
63MP0002138_abnormal_hepatobiliary_system0.71799375
64MP0002109_abnormal_limb_morphology0.70934052
65MP0003693_abnormal_embryo_hatching0.70262886
66MP0001800_abnormal_humoral_immune0.70093928
67MP0009763_increased_sensitivity_to0.69949329
68MP0001835_abnormal_antigen_presentation0.68898615
69MP0002822_catalepsy0.65585689
70MP0002405_respiratory_system_inflammati0.65443064
71MP0005395_other_phenotype0.62362763
72MP0003786_premature_aging0.61143296
73MP0005410_abnormal_fertilization0.60572322
74MP0002184_abnormal_innervation0.60067150
75MP0003878_abnormal_ear_physiology0.58772813
76MP0005377_hearing/vestibular/ear_phenot0.58772813
77MP0001986_abnormal_taste_sensitivity0.58582709
78MP0003011_delayed_dark_adaptation0.58389786
79MP0004142_abnormal_muscle_tone0.58375438
80MP0003942_abnormal_urinary_system0.56994437
81MP0002837_dystrophic_cardiac_calcinosis0.56134747
82MP0005025_abnormal_response_to0.54942917
83MP0000428_abnormal_craniofacial_morphol0.54924324
84MP0010094_abnormal_chromosome_stability0.54253597
85MP0001790_abnormal_immune_system0.54251712
86MP0005387_immune_system_phenotype0.54251712
87MP0002148_abnormal_hypersensitivity_rea0.53225198
88MP0002115_abnormal_skeleton_extremities0.52522177
89MP0001929_abnormal_gametogenesis0.51547861
90MP0009764_decreased_sensitivity_to0.51028624
91MP0002452_abnormal_antigen_presenting0.50932680
92MP0003638_abnormal_response/metabolism_0.50748800
93MP0000477_abnormal_intestine_morphology0.50423917
94MP0000470_abnormal_stomach_morphology0.49056163
95MP0005075_abnormal_melanosome_morpholog0.48539438
96MP0005167_abnormal_blood-brain_barrier0.47745879
97MP0001666_abnormal_nutrient_absorption0.47646218
98MP0009333_abnormal_splenocyte_physiolog0.47205979
99MP0010386_abnormal_urinary_bladder0.46809438
100MP0008877_abnormal_DNA_methylation0.46446295

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of long-chain fatty-acid metabolism (HP:0010964)8.82993373
2Duplicated collecting system (HP:0000081)7.07958663
3Abnormality of the renal collecting system (HP:0004742)6.45476996
4Long foot (HP:0001833)5.95263917
5Abnormality of fatty-acid metabolism (HP:0004359)5.46365351
6Large for gestational age (HP:0001520)5.39004732
7Adactyly (HP:0009776)5.06588033
8Progressive muscle weakness (HP:0003323)4.53092832
9Hypoplastic pelvis (HP:0008839)4.51727930
10Dry hair (HP:0011359)4.30143528
11Acute lymphatic leukemia (HP:0006721)4.27055717
12Ureteral stenosis (HP:0000071)4.17897581
13Autoamputation (HP:0001218)4.16155533
14Ureteral obstruction (HP:0006000)3.88506856
15Ureteral duplication (HP:0000073)3.82235014
16Reduced subcutaneous adipose tissue (HP:0003758)3.78207299
17Brushfield spots (HP:0001088)3.77687299
18Acute necrotizing encephalopathy (HP:0006965)3.72644123
19Steatorrhea (HP:0002570)3.49941450
20Lactic acidosis (HP:0003128)3.39256125
21Acute encephalopathy (HP:0006846)3.26745986
22Abnormal mitochondria in muscle tissue (HP:0008316)3.26654821
23Pulmonary artery stenosis (HP:0004415)3.24408687
24Mitochondrial inheritance (HP:0001427)3.22454155
253-Methylglutaconic aciduria (HP:0003535)3.21646758
26Menstrual irregularities (HP:0000858)3.09209081
27Hepatocellular necrosis (HP:0001404)3.06347766
28Broad-based gait (HP:0002136)3.05411935
29Progressive macrocephaly (HP:0004481)3.04853558
30Hypoplastic nipples (HP:0002557)3.04064152
31Severe muscular hypotonia (HP:0006829)2.96657310
32Increased serum lactate (HP:0002151)2.96619785
33Fat malabsorption (HP:0002630)2.92584291
34Abnormal auditory evoked potentials (HP:0006958)2.90729356
35Increased CSF lactate (HP:0002490)2.89179415
36Hepatic necrosis (HP:0002605)2.79147000
37Clubbing of toes (HP:0100760)2.76458846
38Anhidrosis (HP:0000970)2.76065589
39Polyneuropathy (HP:0001271)2.64491743
40Decreased muscle mass (HP:0003199)2.62968805
41Exercise intolerance (HP:0003546)2.59249072
42Increased hepatocellular lipid droplets (HP:0006565)2.57013816
43Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.56235351
44Wide intermamillary distance (HP:0006610)2.52167495
45Epiphyseal stippling (HP:0010655)2.51865740
46Renal Fanconi syndrome (HP:0001994)2.43978869
47Cerebral edema (HP:0002181)2.43852928
48Polymicrogyria (HP:0002126)2.42876288
49Sudden death (HP:0001699)2.42184659
50Lipid accumulation in hepatocytes (HP:0006561)2.41574263
51Respiratory failure (HP:0002878)2.41177867
52Transposition of the great arteries (HP:0001669)2.40730450
53Abnormal connection of the cardiac segments (HP:0011545)2.40730450
54Abnormal ventriculo-arterial connection (HP:0011563)2.40730450
55Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.39766477
56Abnormality of alanine metabolism (HP:0010916)2.39766477
57Hyperalaninemia (HP:0003348)2.39766477
58CNS demyelination (HP:0007305)2.37027567
59Increased number of teeth (HP:0011069)2.32781674
60Metabolic acidosis (HP:0001942)2.21152989
61Decreased lacrimation (HP:0000633)2.16963399
62Myoglobinuria (HP:0002913)2.16934069
63Chorioretinal coloboma (HP:0000567)2.15460411
64Palmoplantar hyperkeratosis (HP:0000972)2.13605548
65Rhabdomyolysis (HP:0003201)2.06930885
66Palmar hyperkeratosis (HP:0010765)2.02699232
67Flat face (HP:0012368)1.93990028
68Hyperammonemia (HP:0001987)1.92015665
69Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.90365724
70Female pseudohermaphroditism (HP:0010458)1.87389092
71Optic disc pallor (HP:0000543)1.86255336
72Generalized aminoaciduria (HP:0002909)1.85969161
73Decreased electroretinogram (ERG) amplitude (HP:0000654)1.83906113
74Lethargy (HP:0001254)1.79287670
75Anxiety (HP:0000739)1.77930359
76Congenital, generalized hypertrichosis (HP:0004540)1.77018193
77Spastic tetraplegia (HP:0002510)1.76235931
78Abnormality of vision evoked potentials (HP:0000649)1.74971114
79Large hands (HP:0001176)1.73263288
80Gangrene (HP:0100758)1.73257024
81Abnormal epiphyseal ossification (HP:0010656)1.72460677
82Congenital stationary night blindness (HP:0007642)1.71215647
83Widely spaced teeth (HP:0000687)1.70235865
84Exertional dyspnea (HP:0002875)1.69720797
85Increased intramyocellular lipid droplets (HP:0012240)1.68719638
86Glycosuria (HP:0003076)1.64874525
87Abnormality of urine glucose concentration (HP:0011016)1.64874525
88Congenital onset (HP:0003577)1.63674730
89Hypothermia (HP:0002045)1.63673675
90Plantar hyperkeratosis (HP:0007556)1.62965384
91Aplasia/Hypoplasia of the nipples (HP:0006709)1.61121862
92Aplastic anemia (HP:0001915)1.60358519
93Methylmalonic aciduria (HP:0012120)1.60247305
94Abnormality of renal resorption (HP:0011038)1.58361247
95Postnatal microcephaly (HP:0005484)1.58203875
96Retinopathy (HP:0000488)1.57884400
97Constricted visual fields (HP:0001133)1.56355999
98Generalized amyotrophy (HP:0003700)1.56035808
99Overfolded helix (HP:0000396)1.54933589
100Hypoplastic iliac wings (HP:0002866)1.51623412

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MKNK16.41846767
2TAOK15.20174417
3TAOK24.69201198
4MAP3K33.68131171
5MAP3K113.48557168
6MAP2K33.31638445
7JAK32.07927319
8MKNK210.6405215
9SRPK11.86171220
10ABL21.71671010
11VRK21.70057824
12DYRK1A1.47407217
13TXK1.31953630
14MAP3K51.25512075
15ZAK1.22980972
16TLK11.00772581
17VRK10.94977342
18TSSK60.89227823
19CHEK20.85221455
20NUAK10.84514616
21BUB10.84334495
22TIE10.83485368
23NEK10.82914742
24MAP4K20.75229570
25TRIM280.73943594
26GRK10.72640525
27ADRBK20.68400682
28CCNB10.65888789
29PRKCQ0.65261214
30BMPR1B0.64606362
31MST40.64161826
32MAP3K10.55016649
33EIF2AK30.51838325
34INSRR0.50748539
35NME10.50109494
36EIF2AK10.49350961
37FRK0.49341190
38PLK30.47958655
39MAP3K80.46360883
40PBK0.46309554
41WNK30.46080773
42CDC70.41717944
43TAF10.41673195
44WNK40.41230743
45BCKDK0.40851889
46PDK20.40235071
47STK390.38319789
48CSNK1G30.37177988
49PLK40.33140464
50CSNK1A10.32969118
51OXSR10.31528894
52KDR0.31026330
53MAP2K70.30760670
54TEC0.26893436
55CSNK1G20.26060596
56CSNK1A1L0.25993315
57CSNK1G10.25709651
58OBSCN0.24234119
59DYRK20.23561040
60GRK50.22999195
61CSNK2A20.22923529
62AURKA0.22103851
63CSNK2A10.21727364
64IGF1R0.20167720
65ACVR1B0.19629423
66PLK20.18327780
67PHKG20.16074403
68PHKG10.16074403
69MAP2K60.15374072
70AURKB0.15265754
71MAP4K10.14667830
72EIF2AK20.14311697
73STK160.14208310
74FES0.13687260
75TGFBR20.12893185
76PRKCD0.12028558
77CSNK1E0.11461311
78ABL10.11048536
79RPS6KA50.10508792
80BCR0.10452155
81PRKCA0.10187573
82MAP3K40.09780432
83ADRBK10.09516381
84PLK10.09504143
85MYLK0.09487673
86STK38L0.09135125
87MAP3K120.09092357
88MATK0.08395683
89ITK0.07885178
90PIM20.07852058
91IKBKB0.07626619
92ATR0.07566790
93DAPK10.07108210
94PRKACA0.06618791
95KIT0.06544317
96MUSK0.05313097
97PRKCG0.04925836
98MAPK130.04904363
99GRK70.03825454
100PRKCB0.03686416

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.99391339
2SNARE interactions in vesicular transport_Homo sapiens_hsa041304.35491280
3Pantothenate and CoA biosynthesis_Homo sapiens_hsa007703.79412382
4RNA polymerase_Homo sapiens_hsa030203.53741016
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.84256485
6One carbon pool by folate_Homo sapiens_hsa006702.55736087
7Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.48360327
8Oxidative phosphorylation_Homo sapiens_hsa001902.48330972
9Parkinsons disease_Homo sapiens_hsa050122.03574374
10Butanoate metabolism_Homo sapiens_hsa006502.03032212
11Propanoate metabolism_Homo sapiens_hsa006401.83987518
12Fatty acid elongation_Homo sapiens_hsa000621.81672775
13Protein export_Homo sapiens_hsa030601.70192773
14Huntingtons disease_Homo sapiens_hsa050161.66171825
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.60288796
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.58901334
17Taste transduction_Homo sapiens_hsa047421.49037024
18Tryptophan metabolism_Homo sapiens_hsa003801.48143727
19Pyrimidine metabolism_Homo sapiens_hsa002401.47366238
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.36386200
21Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.34165601
22Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.32849795
23Nucleotide excision repair_Homo sapiens_hsa034201.30223384
24beta-Alanine metabolism_Homo sapiens_hsa004101.30029442
25Ribosome_Homo sapiens_hsa030101.28745986
26Asthma_Homo sapiens_hsa053101.26664704
27Autoimmune thyroid disease_Homo sapiens_hsa053201.24149639
28Alzheimers disease_Homo sapiens_hsa050101.22905624
29Peroxisome_Homo sapiens_hsa041461.22317009
30RNA transport_Homo sapiens_hsa030131.13938981
31Primary immunodeficiency_Homo sapiens_hsa053401.13214614
32Homologous recombination_Homo sapiens_hsa034401.11556948
33Glycerolipid metabolism_Homo sapiens_hsa005611.11312604
34Allograft rejection_Homo sapiens_hsa053301.11201537
35Purine metabolism_Homo sapiens_hsa002301.07184544
36DNA replication_Homo sapiens_hsa030301.06720271
37Caffeine metabolism_Homo sapiens_hsa002321.05438756
38Sulfur metabolism_Homo sapiens_hsa009201.04289357
39Mismatch repair_Homo sapiens_hsa034301.00817859
40Fat digestion and absorption_Homo sapiens_hsa049750.97698642
41Linoleic acid metabolism_Homo sapiens_hsa005910.97442126
42Graft-versus-host disease_Homo sapiens_hsa053320.96715895
43Systemic lupus erythematosus_Homo sapiens_hsa053220.96512661
44Type I diabetes mellitus_Homo sapiens_hsa049400.96015875
45Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.95964419
46Steroid biosynthesis_Homo sapiens_hsa001000.93611274
47Sulfur relay system_Homo sapiens_hsa041220.91945792
48Intestinal immune network for IgA production_Homo sapiens_hsa046720.90817054
49Base excision repair_Homo sapiens_hsa034100.90814560
50Fatty acid degradation_Homo sapiens_hsa000710.87026825
51Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.83078592
52Lysine degradation_Homo sapiens_hsa003100.81310118
53Nitrogen metabolism_Homo sapiens_hsa009100.79213827
54alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.79058329
552-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.76069836
56Cysteine and methionine metabolism_Homo sapiens_hsa002700.75717136
57Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.74485414
58Cardiac muscle contraction_Homo sapiens_hsa042600.74132007
59Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.73273774
60Maturity onset diabetes of the young_Homo sapiens_hsa049500.72628913
61Vitamin digestion and absorption_Homo sapiens_hsa049770.71161898
62Metabolic pathways_Homo sapiens_hsa011000.69966665
63Phototransduction_Homo sapiens_hsa047440.69818473
64Fatty acid metabolism_Homo sapiens_hsa012120.69184684
65RNA degradation_Homo sapiens_hsa030180.66611984
66Chemical carcinogenesis_Homo sapiens_hsa052040.63786795
67Collecting duct acid secretion_Homo sapiens_hsa049660.62615121
68Retinol metabolism_Homo sapiens_hsa008300.62472992
69Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.60729763
70Viral myocarditis_Homo sapiens_hsa054160.60192656
71Rheumatoid arthritis_Homo sapiens_hsa053230.59289920
72Epstein-Barr virus infection_Homo sapiens_hsa051690.58251037
73Antigen processing and presentation_Homo sapiens_hsa046120.55982180
74Ether lipid metabolism_Homo sapiens_hsa005650.55898140
75Non-homologous end-joining_Homo sapiens_hsa034500.55780027
76Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.55422272
77Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.54117516
78Basal transcription factors_Homo sapiens_hsa030220.53821096
79Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.53622309
80Spliceosome_Homo sapiens_hsa030400.53241748
81Carbon metabolism_Homo sapiens_hsa012000.52752943
82Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.51699097
83Fanconi anemia pathway_Homo sapiens_hsa034600.51438206
84Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.51355607
85Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.47783413
86Vitamin B6 metabolism_Homo sapiens_hsa007500.47714699
87Hematopoietic cell lineage_Homo sapiens_hsa046400.47503181
88Glutathione metabolism_Homo sapiens_hsa004800.46834912
89Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44065916
90Olfactory transduction_Homo sapiens_hsa047400.43868505
91Steroid hormone biosynthesis_Homo sapiens_hsa001400.43057919
92Arginine biosynthesis_Homo sapiens_hsa002200.42433854
93Nicotine addiction_Homo sapiens_hsa050330.42024473
94Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.39075740
95Pyruvate metabolism_Homo sapiens_hsa006200.39035563
96Arachidonic acid metabolism_Homo sapiens_hsa005900.37852565
97Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.36906962
98Pentose and glucuronate interconversions_Homo sapiens_hsa000400.36457623
99Selenocompound metabolism_Homo sapiens_hsa004500.36249907
100Folate biosynthesis_Homo sapiens_hsa007900.35276913

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