ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	protein prenylation (GO:0018342)	8.01426086
2	prenylation (GO:0097354)	8.01426086
3	positive regulation of mitotic sister chromatid separation (GO:1901970)	7.02987411
4	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	7.02987411
5	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	7.02987411
6	fucose catabolic process (GO:0019317)	6.27499358
7	L-fucose metabolic process (GO:0042354)	6.27499358
8	L-fucose catabolic process (GO:0042355)	6.27499358
9	regulation of sister chromatid cohesion (GO:0007063)	5.99590645
10	negative regulation of Ras GTPase activity (GO:0034261)	5.58222133
11	negative regulation of T cell receptor signaling pathway (GO:0050860)	5.52028818
12	proteasome assembly (GO:0043248)	4.84997548
13	eosinophil chemotaxis (GO:0048245)	4.79140316
14	branch elongation of an epithelium (GO:0060602)	4.76302195
15	positive regulation of chromosome segregation (GO:0051984)	4.66551514
16	DNA integration (GO:0015074)	4.61285286
17	eosinophil migration (GO:0072677)	4.36038446
18	acrosome assembly (GO:0001675)	4.31215675
19	negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)	4.30250740
20	organ growth (GO:0035265)	4.17381037
21	replication fork processing (GO:0031297)	4.00978097
22	coenzyme A biosynthetic process (GO:0015937)	4.00655366
23	limb bud formation (GO:0060174)	3.98149385
24	histone H3-K9 methylation (GO:0051567)	3.95223355
25	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	3.91819908
26	seminiferous tubule development (GO:0072520)	3.88091535
27	ribosomal small subunit assembly (GO:0000028)	3.83510643
28	vesicle fusion (GO:0006906)	3.83266322
29	regulation of mononuclear cell migration (GO:0071675)	3.81233434
30	negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)	3.79496869
31	double-strand break repair via nonhomologous end joining (GO:0006303)	3.78266719
32	non-recombinational repair (GO:0000726)	3.78266719
33	macrophage chemotaxis (GO:0048246)	3.72979234
34	DNA demethylation (GO:0080111)	3.70884443
35	regulation of T cell receptor signaling pathway (GO:0050856)	3.69458591
36	protein sumoylation (GO:0016925)	3.66306914
37	oxidative demethylation (GO:0070989)	3.65041028
38	peptidyl-lysine dimethylation (GO:0018027)	3.59549352
39	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.50360854
40	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.50360854
41	regulation of translation, ncRNA-mediated (GO:0045974)	3.50360854
42	negative regulation of peptidyl-threonine phosphorylation (GO:0010801)	3.47766902
43	somatic diversification of immune receptors via somatic mutation (GO:0002566)	3.47351537
44	somatic hypermutation of immunoglobulin genes (GO:0016446)	3.47351537
45	detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)	3.38627461
46	preassembly of GPI anchor in ER membrane (GO:0016254)	3.36221125
47	response to pheromone (GO:0019236)	3.31511619
48	autophagic vacuole fusion (GO:0000046)	3.30569505
49	axis elongation (GO:0003401)	3.21676302
50	histone H2A acetylation (GO:0043968)	3.19697425
51	telomere maintenance via recombination (GO:0000722)	3.19477856
52	fucosylation (GO:0036065)	3.11564418
53	mitotic recombination (GO:0006312)	3.05689020
54	peptidyl-lysine trimethylation (GO:0018023)	3.04574025
55	detection of chemical stimulus involved in sensory perception of taste (GO:0050912)	3.02232277
56	organelle membrane fusion (GO:0090174)	2.99584783
57	histone H3-K9 modification (GO:0061647)	2.99368908
58	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.98927704
59	double-strand break repair via homologous recombination (GO:0000724)	2.95790871
60	recombinational repair (GO:0000725)	2.94953940
61	regulation of timing of cell differentiation (GO:0048505)	2.93463529
62	signal peptide processing (GO:0006465)	2.92579574
63	protein targeting to vacuole (GO:0006623)	2.92553715
64	protein targeting to lysosome (GO:0006622)	2.92553715
65	establishment of protein localization to vacuole (GO:0072666)	2.92553715
66	positive regulation of calcium ion import (GO:0090280)	2.90679677
67	fucose metabolic process (GO:0006004)	2.90009414
68	DNA double-strand break processing (GO:0000729)	2.88252118
69	regulation of nitric-oxide synthase biosynthetic process (GO:0051769)	2.84969591
70	DNA dealkylation (GO:0035510)	2.83166680
71	protein K6-linked ubiquitination (GO:0085020)	2.82445528
72	pantothenate metabolic process (GO:0015939)	2.82131346
73	regulation of alternative mRNA splicing, via spliceosome (GO:0000381)	2.79509386
74	mitochondrial RNA metabolic process (GO:0000959)	2.79420693
75	neural tube formation (GO:0001841)	2.76602915
76	protein import into peroxisome matrix (GO:0016558)	2.72936312
77	coenzyme A metabolic process (GO:0015936)	2.71549248
78	glial cell proliferation (GO:0014009)	2.66249803
79	negative regulation of dendrite development (GO:2000171)	2.64321878
80	regulation of development, heterochronic (GO:0040034)	2.63660235
81	ribonucleoside bisphosphate biosynthetic process (GO:0034030)	2.63213291
82	nucleoside bisphosphate biosynthetic process (GO:0033866)	2.63213291
83	purine nucleoside bisphosphate biosynthetic process (GO:0034033)	2.63213291
84	DNA deamination (GO:0045006)	2.59117176
85	kinetochore assembly (GO:0051382)	2.58363180
86	cell wall macromolecule catabolic process (GO:0016998)	2.57272238
87	metallo-sulfur cluster assembly (GO:0031163)	2.54854056
88	iron-sulfur cluster assembly (GO:0016226)	2.54854056
89	intraciliary transport (GO:0042073)	2.53161314
90	termination of RNA polymerase III transcription (GO:0006386)	2.52444327
91	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.52444327
92	retinal ganglion cell axon guidance (GO:0031290)	2.50661538
93	DNA damage response, detection of DNA damage (GO:0042769)	2.48109198
94	platelet dense granule organization (GO:0060155)	2.47679255
95	C-terminal protein lipidation (GO:0006501)	2.47239429
96	respiratory chain complex IV assembly (GO:0008535)	2.46324702
97	regulation of antigen receptor-mediated signaling pathway (GO:0050854)	2.45340857
98	sympathetic nervous system development (GO:0048485)	2.45302843
99	pyrimidine nucleobase catabolic process (GO:0006208)	2.41350336
100	negative regulation of circadian rhythm (GO:0042754)	2.39070506

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	5.23423767
2	VDR_22108803_ChIP-Seq_LS180_Human	4.83619747
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.88227178
4	GATA1_22025678_ChIP-Seq_K562_Human	3.75757910
5	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.25998042
6	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.19273545
7	ZNF274_21170338_ChIP-Seq_K562_Hela	3.14900506
8	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.61512898
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.47836574
10	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.45747776
11	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.38247541
12	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.26698406
13	ELK1_19687146_ChIP-ChIP_HELA_Human	2.24689732
14	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.19907144
15	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.10598789
16	TAF15_26573619_Chip-Seq_HEK293_Human	2.08972665
17	EWS_26573619_Chip-Seq_HEK293_Human	2.07356239
18	P300_19829295_ChIP-Seq_ESCs_Human	2.01923717
19	FUS_26573619_Chip-Seq_HEK293_Human	2.00660473
20	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.97225131
21	GBX2_23144817_ChIP-Seq_PC3_Human	1.92692502
22	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.86755783
23	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.84786562
24	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.83906560
25	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.76536546
26	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.74498473
27	VDR_23849224_ChIP-Seq_CD4+_Human	1.72758431
28	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.72569576
29	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.71350322
30	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.66082284
31	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.65384793
32	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.62745546
33	IRF1_19129219_ChIP-ChIP_H3396_Human	1.62721606
34	BCAT_22108803_ChIP-Seq_LS180_Human	1.61577196
35	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.58306445
36	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.53242154
37	IGF1R_20145208_ChIP-Seq_DFB_Human	1.52477850
38	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.49843458
39	AR_21572438_ChIP-Seq_LNCaP_Human	1.46977851
40	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.46840855
41	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.46715571
42	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.46512378
43	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.43012105
44	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.43012105
45	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.37115765
46	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.36604144
47	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.35710990
48	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.33727693
49	TP53_22573176_ChIP-Seq_HFKS_Human	1.32780998
50	FOXP3_21729870_ChIP-Seq_TREG_Human	1.32201268
51	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.29745012
52	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.28684837
53	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.28420821
54	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.27385315
55	TCF4_22108803_ChIP-Seq_LS180_Human	1.25434082
56	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.25184248
57	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.20453520
58	ER_23166858_ChIP-Seq_MCF-7_Human	1.20342582
59	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.16717716
60	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.16675544
61	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.13215339
62	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.13077512
63	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.11573842
64	TP53_16413492_ChIP-PET_HCT116_Human	1.11256259
65	CBP_20019798_ChIP-Seq_JUKART_Human	1.10671328
66	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.10671328
67	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.10252819
68	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.09152994
69	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.06990199
70	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.06772011
71	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.06567467
72	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.05605619
73	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.05282994
74	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.05217818
75	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.04726036
76	NANOG_19829295_ChIP-Seq_ESCs_Human	1.03584202
77	SOX2_19829295_ChIP-Seq_ESCs_Human	1.03584202
78	SMAD4_21799915_ChIP-Seq_A2780_Human	1.03114719
79	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.01744602
80	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.01322256
81	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.01322256
82	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.00040313
83	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	0.99934558
84	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.99512184
85	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.99401223
86	RUNX2_22187159_ChIP-Seq_PCA_Human	0.97376341
87	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	0.97159798
88	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.96829122
89	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.95679572
90	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.95111280
91	P53_22387025_ChIP-Seq_ESCs_Mouse	0.94157610
92	AR_25329375_ChIP-Seq_VCAP_Human	0.93674035
93	STAT3_23295773_ChIP-Seq_U87_Human	0.92252594
94	RNF2_27304074_Chip-Seq_NSC_Mouse	0.92122558
95	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.91638509
96	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	0.91591127
97	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.90118552
98	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.89929541
99	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	0.89851095
100	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.88434893

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000566_synostosis	9.91361274
2	MP0003303_peritoneal_inflammation	3.11600521
3	MP0008058_abnormal_DNA_repair	2.65560203
4	MP0002751_abnormal_autonomic_nervous	2.55121860
5	MP0000383_abnormal_hair_follicle	2.48281788
6	MP0008877_abnormal_DNA_methylation	2.41611557
7	MP0003693_abnormal_embryo_hatching	2.21301046
8	MP0002736_abnormal_nociception_after	2.11778618
9	MP0002102_abnormal_ear_morphology	2.05613713
10	MP0008057_abnormal_DNA_replication	2.01357576
11	MP0001919_abnormal_reproductive_system	1.98228811
12	MP0003011_delayed_dark_adaptation	1.95139974
13	MP0000467_abnormal_esophagus_morphology	1.93741310
14	MP0003880_abnormal_central_pattern	1.91981654
15	MP0003937_abnormal_limbs/digits/tail_de	1.91596149
16	MP0001293_anophthalmia	1.86044317
17	MP0008789_abnormal_olfactory_epithelium	1.74948157
18	MP0006082_CNS_inflammation	1.74259290
19	MP0006292_abnormal_olfactory_placode	1.67407672
20	MP0002938_white_spotting	1.60020292
21	MP0000372_irregular_coat_pigmentation	1.58645747
22	MP0010094_abnormal_chromosome_stability	1.52360872
23	MP0010678_abnormal_skin_adnexa	1.50058265
24	MP0005253_abnormal_eye_physiology	1.47494150
25	MP0003121_genomic_imprinting	1.46333044
26	MP0003115_abnormal_respiratory_system	1.43328587
27	MP0003787_abnormal_imprinting	1.42819639
28	MP0001664_abnormal_digestion	1.40243464
29	MP0002282_abnormal_trachea_morphology	1.39389626
30	MP0001764_abnormal_homeostasis	1.38917891
31	MP0001529_abnormal_vocalization	1.35288398
32	MP0001286_abnormal_eye_development	1.35031432
33	MP0005551_abnormal_eye_electrophysiolog	1.33455498
34	MP0000049_abnormal_middle_ear	1.33067616
35	MP0002210_abnormal_sex_determination	1.28727574
36	MP0001968_abnormal_touch/_nociception	1.28714605
37	MP0005389_reproductive_system_phenotype	1.27767362
38	MP0005394_taste/olfaction_phenotype	1.26276350
39	MP0005499_abnormal_olfactory_system	1.26276350
40	MP0001663_abnormal_digestive_system	1.25633577
41	MP0003136_yellow_coat_color	1.23717160
42	MP0003567_abnormal_fetal_cardiomyocyte	1.20494723
43	MP0005646_abnormal_pituitary_gland	1.19082735
44	MP0000427_abnormal_hair_cycle	1.16129032
45	MP0002233_abnormal_nose_morphology	1.14694367
46	MP0000428_abnormal_craniofacial_morphol	1.14478797
47	MP0002234_abnormal_pharynx_morphology	1.08013622
48	MP0002277_abnormal_respiratory_mucosa	1.07589285
49	MP0002837_dystrophic_cardiac_calcinosis	1.07347320
50	MP0000647_abnormal_sebaceous_gland	1.05742101
51	MP0008872_abnormal_physiological_respon	1.01434671
52	MP0001984_abnormal_olfaction	0.99779183
53	MP0002822_catalepsy	0.98671097
54	MP0000631_abnormal_neuroendocrine_gland	0.93715598
55	MP0003195_calcinosis	0.92671672
56	MP0001145_abnormal_male_reproductive	0.92539954
57	MP0006072_abnormal_retinal_apoptosis	0.91507621
58	MP0005391_vision/eye_phenotype	0.91302274
59	MP0003718_maternal_effect	0.90396558
60	MP0006276_abnormal_autonomic_nervous	0.90008793
61	MP0002876_abnormal_thyroid_physiology	0.89751286
62	MP0002109_abnormal_limb_morphology	0.89441912
63	MP0003755_abnormal_palate_morphology	0.88763499
64	MP0001929_abnormal_gametogenesis	0.88245549
65	MP0005367_renal/urinary_system_phenotyp	0.88025695
66	MP0000516_abnormal_urinary_system	0.88025695
67	MP0001485_abnormal_pinna_reflex	0.87904482
68	MP0000653_abnormal_sex_gland	0.87084977
69	MP0003935_abnormal_craniofacial_develop	0.86855664
70	MP0002095_abnormal_skin_pigmentation	0.85497803
71	MP0000026_abnormal_inner_ear	0.84937554
72	MP0005381_digestive/alimentary_phenotyp	0.83710411
73	MP0003119_abnormal_digestive_system	0.83241419
74	MP0003938_abnormal_ear_development	0.83006619
75	MP0004147_increased_porphyrin_level	0.82955426
76	MP0005085_abnormal_gallbladder_physiolo	0.82864850
77	MP0002184_abnormal_innervation	0.82087085
78	MP0002254_reproductive_system_inflammat	0.82069319
79	MP0004133_heterotaxia	0.81383219
80	MP0003786_premature_aging	0.80643905
81	MP0001486_abnormal_startle_reflex	0.79608652
82	MP0003122_maternal_imprinting	0.78844840
83	MP0003252_abnormal_bile_duct	0.77376098
84	MP0001963_abnormal_hearing_physiology	0.76414080
85	MP0002653_abnormal_ependyma_morphology	0.75906525
86	MP0004142_abnormal_muscle_tone	0.74118561
87	MP0008932_abnormal_embryonic_tissue	0.72292813
88	MP0004145_abnormal_muscle_electrophysio	0.71993844
89	MP0008875_abnormal_xenobiotic_pharmacok	0.71893172
90	MP0009745_abnormal_behavioral_response	0.71766352
91	MP0000534_abnormal_ureter_morphology	0.69774916
92	MP0003936_abnormal_reproductive_system	0.69374967
93	MP0003698_abnormal_male_reproductive	0.67697986
94	MP0003077_abnormal_cell_cycle	0.67532924
95	MP0002752_abnormal_somatic_nervous	0.66436348
96	MP0001188_hyperpigmentation	0.65774823
97	MP0000778_abnormal_nervous_system	0.65715662
98	MP0005377_hearing/vestibular/ear_phenot	0.65220285
99	MP0003878_abnormal_ear_physiology	0.65220285
100	MP0005084_abnormal_gallbladder_morpholo	0.64579022

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	5.01760714
2	Duplicated collecting system (HP:0000081)	4.46159068
3	Hypoplastic pelvis (HP:0008839)	4.44157337
4	Intestinal atresia (HP:0011100)	4.40800008
5	Abnormality of the renal collecting system (HP:0004742)	3.94284483
6	Adactyly (HP:0009776)	3.47384709
7	Large for gestational age (HP:0001520)	3.44066020
8	Broad-based gait (HP:0002136)	3.43759381
9	Long foot (HP:0001833)	3.23839370
10	Abnormality of the labia minora (HP:0012880)	3.22137452
11	Acute lymphatic leukemia (HP:0006721)	3.03716183
12	True hermaphroditism (HP:0010459)	2.97287072
13	Pancreatic cysts (HP:0001737)	2.93337018
14	Pancreatic fibrosis (HP:0100732)	2.92187154
15	Ependymoma (HP:0002888)	2.87461083
16	Abnormality of midbrain morphology (HP:0002418)	2.86462923
17	Molar tooth sign on MRI (HP:0002419)	2.86462923
18	Pendular nystagmus (HP:0012043)	2.83024705
19	Abnormality of fatty-acid metabolism (HP:0004359)	2.82349995
20	Abnormality of the astrocytes (HP:0100707)	2.67136380
21	Astrocytoma (HP:0009592)	2.67136380
22	Abnormal lung lobation (HP:0002101)	2.60198979
23	Volvulus (HP:0002580)	2.59156421
24	Dry hair (HP:0011359)	2.55345882
25	Widely spaced teeth (HP:0000687)	2.55293220
26	Nephronophthisis (HP:0000090)	2.51461834
27	Clubbing of toes (HP:0100760)	2.48343903
28	Severe muscular hypotonia (HP:0006829)	2.44432281
29	Tubular atrophy (HP:0000092)	2.39638052
30	Type II lissencephaly (HP:0007260)	2.39065383
31	Congenital stationary night blindness (HP:0007642)	2.38617924
32	Gastrointestinal atresia (HP:0002589)	2.35692856
33	Ureteral duplication (HP:0000073)	2.32460438
34	Glioma (HP:0009733)	2.30958087
35	Hypoplastic iliac wings (HP:0002866)	2.30551315
36	Abnormal biliary tract physiology (HP:0012439)	2.24058022
37	Bile duct proliferation (HP:0001408)	2.24058022
38	Azoospermia (HP:0000027)	2.21391986
39	Abnormality of the renal cortex (HP:0011035)	2.18735241
40	Abnormality of the renal medulla (HP:0100957)	2.16286720
41	Pulmonary artery stenosis (HP:0004415)	2.14398063
42	Decreased lacrimation (HP:0000633)	2.12155878
43	Steatorrhea (HP:0002570)	2.10765941
44	Abnormal auditory evoked potentials (HP:0006958)	2.06238288
45	Autoamputation (HP:0001218)	2.02976570
46	Medial flaring of the eyebrow (HP:0010747)	2.01153601
47	Polymicrogyria (HP:0002126)	2.00681562
48	Chorioretinal coloboma (HP:0000567)	2.00401412
49	Decreased muscle mass (HP:0003199)	1.99447989
50	Chronic hepatic failure (HP:0100626)	1.97272072
51	Abolished electroretinogram (ERG) (HP:0000550)	1.96426296
52	Wide intermamillary distance (HP:0006610)	1.95696107
53	Male pseudohermaphroditism (HP:0000037)	1.95420426
54	Increased number of teeth (HP:0011069)	1.94665998
55	Oligodactyly (hands) (HP:0001180)	1.93916175
56	Cystic liver disease (HP:0006706)	1.92454704
57	Epidermoid cyst (HP:0200040)	1.92339805
58	Severe visual impairment (HP:0001141)	1.92290511
59	Colon cancer (HP:0003003)	1.90851650
60	Hypoplastic nipples (HP:0002557)	1.90684132
61	Dandy-Walker malformation (HP:0001305)	1.89985683
62	Small hand (HP:0200055)	1.89745216
63	Brushfield spots (HP:0001088)	1.88495242
64	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.86936765
65	Lissencephaly (HP:0001339)	1.83923106
66	Anencephaly (HP:0002323)	1.83436945
67	Scrotal hypoplasia (HP:0000046)	1.82411590
68	Sloping forehead (HP:0000340)	1.82101875
69	Abnormality of lateral ventricle (HP:0030047)	1.81410659
70	Abnormality of the duodenum (HP:0002246)	1.80075342
71	Postaxial foot polydactyly (HP:0001830)	1.77795393
72	Vaginal atresia (HP:0000148)	1.76979347
73	3-Methylglutaconic aciduria (HP:0003535)	1.76607675
74	Hyperventilation (HP:0002883)	1.75636750
75	Rhabdomyosarcoma (HP:0002859)	1.75174154
76	Tubulointerstitial nephritis (HP:0001970)	1.75001805
77	Mesangial abnormality (HP:0001966)	1.74824037
78	Patellar aplasia (HP:0006443)	1.74001446
79	Anhidrosis (HP:0000970)	1.73688892
80	Genital tract atresia (HP:0001827)	1.73548220
81	Aqueductal stenosis (HP:0002410)	1.72547117
82	Gonadotropin excess (HP:0000837)	1.72249888
83	Micropenis (HP:0000054)	1.71261158
84	Growth hormone deficiency (HP:0000824)	1.70982225
85	Bifid tongue (HP:0010297)	1.70507899
86	Synostosis involving the elbow (HP:0003938)	1.70438251
87	Humeroradial synostosis (HP:0003041)	1.70438251
88	Lactic acidosis (HP:0003128)	1.70222911
89	Female pseudohermaphroditism (HP:0010458)	1.69402374
90	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.68257998
91	Progressive muscle weakness (HP:0003323)	1.65652939
92	Calf muscle hypertrophy (HP:0008981)	1.65428064
93	Abnormal spermatogenesis (HP:0008669)	1.65265663
94	Duodenal stenosis (HP:0100867)	1.64848902
95	Small intestinal stenosis (HP:0012848)	1.64848902
96	Absent speech (HP:0001344)	1.64839795
97	Agnosia (HP:0010524)	1.64602426
98	Preaxial hand polydactyly (HP:0001177)	1.64420735
99	Anophthalmia (HP:0000528)	1.64220944
100	Lipid accumulation in hepatocytes (HP:0006561)	1.61907037

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MKNK2	9.07517899
2	MKNK1	5.41027384
3	TAOK1	3.44909281
4	TAOK2	2.95968683
5	TRIM28	2.58821849
6	STK16	2.38564434
7	WNK3	2.26026551
8	FRK	2.10675301
9	SRPK1	2.05430791
10	MAP3K11	2.02025706
11	MAP3K3	1.88615942
12	MAP4K2	1.81519056
13	BMPR1B	1.68725751
14	ACVR1B	1.59927915
15	MARK1	1.59732526
16	EPHA4	1.57648811
17	MAP2K3	1.55272832
18	NUAK1	1.51630312
19	VRK1	1.51087974
20	MAPK13	1.49407200
21	TNIK	1.43439210
22	MST4	1.42922804
23	DYRK1A	1.39381079
24	ABL2	1.35120401
25	BUB1	1.34588422
26	WEE1	1.27081039
27	VRK2	1.20031459
28	ZAK	1.18689228
29	ERBB3	1.17705845
30	PLK3	1.17546912
31	JAK3	1.13477276
32	ADRBK2	1.01310906
33	GRK1	0.98136311
34	CHEK2	0.97977711
35	MAP3K5	0.95620399
36	MAP3K4	0.90799730
37	TNK2	0.89250667
38	CASK	0.87960466
39	NME1	0.86687051
40	CDC7	0.85883220
41	TSSK6	0.82907018
42	BRD4	0.79801810
43	NEK1	0.78924009
44	STK38L	0.76608340
45	BCR	0.76476247
46	STK39	0.74384041
47	EIF2AK3	0.73475834
48	OXSR1	0.67022074
49	CCNB1	0.65277279
50	AKT3	0.63643786
51	PLK4	0.62209278
52	TTK	0.61442795
53	EIF2AK1	0.61102880
54	DYRK2	0.59246684
55	TGFBR1	0.58938612
56	MINK1	0.58402215
57	BRSK2	0.57744479
58	PRKCQ	0.57258335
59	INSRR	0.56206606
60	MARK3	0.52513699
61	PDK2	0.51266546
62	FLT3	0.49449362
63	SIK3	0.48847256
64	TIE1	0.47006288
65	PRKCG	0.46155462
66	PLK2	0.45112423
67	CSNK1A1	0.44137431
68	CSNK1G1	0.42622205
69	ATR	0.41544537
70	PLK1	0.40828211
71	CSNK1G3	0.35314842
72	TLK1	0.35038768
73	PRKCE	0.34635652
74	FER	0.34075602
75	ATM	0.32710562
76	CSNK1G2	0.32031435
77	TEC	0.31200707
78	CSNK1A1L	0.30983403
79	ABL1	0.29928169
80	PAK3	0.29318089
81	ERBB4	0.28965018
82	DYRK3	0.27816504
83	CDK3	0.27512532
84	PBK	0.27465575
85	FGFR2	0.27192078
86	CSNK1E	0.26968938
87	BCKDK	0.26697561
88	PKN1	0.25962620
89	MAP2K7	0.24055830
90	NTRK3	0.23534461
91	IGF1R	0.23319958
92	CSNK2A2	0.23099047
93	YES1	0.23095209
94	CSNK2A1	0.22966004
95	TAOK3	0.21573693
96	OBSCN	0.20724633
97	EIF2AK2	0.20450312
98	CAMK2D	0.18451144
99	NEK2	0.18187741
100	PRKACA	0.17759778

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	RNA polymerase_Homo sapiens_hsa03020	3.35059773
2	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	3.03519054
3	Propanoate metabolism_Homo sapiens_hsa00640	3.01469619
4	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.86744479
5	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	2.85922868
6	Proteasome_Homo sapiens_hsa03050	2.66591571
7	Butanoate metabolism_Homo sapiens_hsa00650	2.63356494
8	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.59027191
9	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.41564050
10	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.25288854
11	Tryptophan metabolism_Homo sapiens_hsa00380	2.19441512
12	Fanconi anemia pathway_Homo sapiens_hsa03460	2.19112120
13	Homologous recombination_Homo sapiens_hsa03440	2.12482536
14	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.12268710
15	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	2.05794131
16	Protein export_Homo sapiens_hsa03060	2.00611293
17	Fatty acid elongation_Homo sapiens_hsa00062	1.97353918
18	Non-homologous end-joining_Homo sapiens_hsa03450	1.93346515
19	Mismatch repair_Homo sapiens_hsa03430	1.85939452
20	Lysine degradation_Homo sapiens_hsa00310	1.79224899
21	One carbon pool by folate_Homo sapiens_hsa00670	1.71012735
22	Base excision repair_Homo sapiens_hsa03410	1.70655143
23	Nitrogen metabolism_Homo sapiens_hsa00910	1.66354001
24	Taste transduction_Homo sapiens_hsa04742	1.64643912
25	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.58169241
26	Nucleotide excision repair_Homo sapiens_hsa03420	1.55463199
27	RNA transport_Homo sapiens_hsa03013	1.52967769
28	Phototransduction_Homo sapiens_hsa04744	1.44514243
29	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.44176561
30	Caffeine metabolism_Homo sapiens_hsa00232	1.42999956
31	beta-Alanine metabolism_Homo sapiens_hsa00410	1.40749570
32	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.39481236
33	Steroid biosynthesis_Homo sapiens_hsa00100	1.25445206
34	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.24347135
35	Peroxisome_Homo sapiens_hsa04146	1.24071008
36	DNA replication_Homo sapiens_hsa03030	1.23690605
37	Nicotine addiction_Homo sapiens_hsa05033	1.23661137
38	Basal transcription factors_Homo sapiens_hsa03022	1.20802273
39	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.19525851
40	Pyrimidine metabolism_Homo sapiens_hsa00240	1.17280126
41	Oxidative phosphorylation_Homo sapiens_hsa00190	1.16524819
42	Fatty acid degradation_Homo sapiens_hsa00071	1.11867122
43	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.06455440
44	RNA degradation_Homo sapiens_hsa03018	1.04446690
45	Linoleic acid metabolism_Homo sapiens_hsa00591	1.03941902
46	Purine metabolism_Homo sapiens_hsa00230	1.02090355
47	Glycerolipid metabolism_Homo sapiens_hsa00561	1.00712691
48	Fatty acid metabolism_Homo sapiens_hsa01212	0.95092131
49	Huntingtons disease_Homo sapiens_hsa05016	0.93691858
50	p53 signaling pathway_Homo sapiens_hsa04115	0.89679478
51	Retinol metabolism_Homo sapiens_hsa00830	0.89435040
52	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.87799810
53	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.86287894
54	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.85206736
55	Parkinsons disease_Homo sapiens_hsa05012	0.85167415
56	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.82039449
57	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.81108935
58	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.81039379
59	Fat digestion and absorption_Homo sapiens_hsa04975	0.78781771
60	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.78608511
61	Pyruvate metabolism_Homo sapiens_hsa00620	0.74121140
62	Chemical carcinogenesis_Homo sapiens_hsa05204	0.71966387
63	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.71784695
64	Oocyte meiosis_Homo sapiens_hsa04114	0.71153127
65	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.70784202
66	Olfactory transduction_Homo sapiens_hsa04740	0.69779637
67	Cell cycle_Homo sapiens_hsa04110	0.67915637
68	Ether lipid metabolism_Homo sapiens_hsa00565	0.65293504
69	mRNA surveillance pathway_Homo sapiens_hsa03015	0.64560388
70	Glutathione metabolism_Homo sapiens_hsa00480	0.63897344
71	Spliceosome_Homo sapiens_hsa03040	0.63444958
72	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.62390662
73	Metabolic pathways_Homo sapiens_hsa01100	0.61216950
74	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.49914695
75	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.49352305
76	ABC transporters_Homo sapiens_hsa02010	0.48685404
77	Mineral absorption_Homo sapiens_hsa04978	0.45347131
78	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.42210840
79	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.40951157
80	Sulfur metabolism_Homo sapiens_hsa00920	0.40428044
81	Collecting duct acid secretion_Homo sapiens_hsa04966	0.37474234
82	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.34329035
83	Basal cell carcinoma_Homo sapiens_hsa05217	0.34049690
84	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.33308023
85	Alzheimers disease_Homo sapiens_hsa05010	0.31249401
86	Amphetamine addiction_Homo sapiens_hsa05031	0.30472859
87	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.29520462
88	Histidine metabolism_Homo sapiens_hsa00340	0.23719099
89	Selenocompound metabolism_Homo sapiens_hsa00450	0.23085758
90	Tyrosine metabolism_Homo sapiens_hsa00350	0.22210808
91	Dopaminergic synapse_Homo sapiens_hsa04728	0.22145933
92	Arginine and proline metabolism_Homo sapiens_hsa00330	0.21948106
93	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.21678898
94	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.17469800
95	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.17440932
96	Wnt signaling pathway_Homo sapiens_hsa04310	0.15822464
97	Regulation of autophagy_Homo sapiens_hsa04140	0.14690564
98	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.14371478
99	Carbon metabolism_Homo sapiens_hsa01200	0.14128366
100	Insulin secretion_Homo sapiens_hsa04911	0.14006703

GAPDHP62

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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