ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	8.45389948
2	protein prenylation (GO:0018342)	8.26322106
3	prenylation (GO:0097354)	8.26322106
4	positive regulation of mitotic sister chromatid separation (GO:1901970)	7.97642428
5	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	7.97642428
6	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	7.97642428
7	negative regulation of Ras GTPase activity (GO:0034261)	7.70361993
8	eosinophil chemotaxis (GO:0048245)	6.03510188
9	regulation of sister chromatid cohesion (GO:0007063)	5.87991134
10	negative regulation of T cell receptor signaling pathway (GO:0050860)	5.71860726
11	branch elongation of an epithelium (GO:0060602)	5.54518709
12	fucose catabolic process (GO:0019317)	5.46788214
13	L-fucose metabolic process (GO:0042354)	5.46788214
14	L-fucose catabolic process (GO:0042355)	5.46788214
15	eosinophil migration (GO:0072677)	5.41147969
16	negative regulation of peptidyl-threonine phosphorylation (GO:0010801)	5.21843308
17	negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)	4.98998274
18	positive regulation of chromosome segregation (GO:0051984)	4.85710116
19	organ growth (GO:0035265)	4.68547400
20	regulation of mononuclear cell migration (GO:0071675)	4.45809617
21	response to gravity (GO:0009629)	4.37206647
22	coenzyme A biosynthetic process (GO:0015937)	4.37078662
23	vesicle fusion (GO:0006906)	4.32686081
24	negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)	4.15827613
25	forebrain neuron differentiation (GO:0021879)	4.13546173
26	protein neddylation (GO:0045116)	3.97572229
27	ganglion development (GO:0061548)	3.92894004
28	peptidyl-lysine dimethylation (GO:0018027)	3.90836695
29	localization within membrane (GO:0051668)	3.89159361
30	negative regulation of muscle hypertrophy (GO:0014741)	3.86962373
31	negative regulation of oligodendrocyte differentiation (GO:0048715)	3.85736959
32	proteasome assembly (GO:0043248)	3.82977350
33	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.80680394
34	axis elongation (GO:0003401)	3.77317054
35	regulation of timing of cell differentiation (GO:0048505)	3.74207011
36	chaperone-mediated protein transport (GO:0072321)	3.58645508
37	acrosome assembly (GO:0001675)	3.49784041
38	termination of RNA polymerase III transcription (GO:0006386)	3.48232230
39	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.48232230
40	auditory behavior (GO:0031223)	3.47783265
41	detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)	3.40698515
42	regulation of T cell receptor signaling pathway (GO:0050856)	3.38083409
43	protein import into peroxisome matrix (GO:0016558)	3.37923318
44	regulation of stem cell maintenance (GO:2000036)	3.34438527
45	positive regulation of calcium ion import (GO:0090280)	3.32688648
46	ATP synthesis coupled proton transport (GO:0015986)	3.32484160
47	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.32484160
48	regulation of skeletal muscle contraction (GO:0014819)	3.25428416
49	autophagic vacuole fusion (GO:0000046)	3.24189695
50	cullin deneddylation (GO:0010388)	3.22261117
51	positive regulation of growth hormone secretion (GO:0060124)	3.22045865
52	regulation of fibroblast growth factor receptor signaling pathway (GO:0040036)	3.18840049
53	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.17749365
54	monocyte chemotaxis (GO:0002548)	3.16995502
55	viral transcription (GO:0019083)	3.15477372
56	non-recombinational repair (GO:0000726)	3.15265121
57	double-strand break repair via nonhomologous end joining (GO:0006303)	3.15265121
58	establishment of mitotic spindle orientation (GO:0000132)	3.14893293
59	regulation of development, heterochronic (GO:0040034)	3.13792631
60	dendritic spine morphogenesis (GO:0060997)	3.11665557
61	macrophage chemotaxis (GO:0048246)	3.11269590
62	negative regulation of circadian rhythm (GO:0042754)	3.11048889
63	oxidative demethylation (GO:0070989)	3.06665406
64	intracellular protein transmembrane import (GO:0044743)	3.05971300
65	response to muscle activity (GO:0014850)	3.05968508
66	translational termination (GO:0006415)	3.02547554
67	protein deneddylation (GO:0000338)	2.99258901
68	behavioral response to nicotine (GO:0035095)	2.99114523
69	regulation of autophagic vacuole assembly (GO:2000785)	2.98894344
70	negative regulation of GTP catabolic process (GO:0033125)	2.98644579
71	negative regulation of GTPase activity (GO:0034260)	2.98644579
72	spinal cord association neuron differentiation (GO:0021527)	2.96081464
73	establishment of spindle orientation (GO:0051294)	2.93238958
74	positive chemotaxis (GO:0050918)	2.91636912
75	translational initiation (GO:0006413)	2.90593853
76	seminiferous tubule development (GO:0072520)	2.87810381
77	preassembly of GPI anchor in ER membrane (GO:0016254)	2.85995600
78	regulation of nitric-oxide synthase biosynthetic process (GO:0051769)	2.85966977
79	translational elongation (GO:0006414)	2.82431376
80	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.80880245
81	NADH dehydrogenase complex assembly (GO:0010257)	2.80880245
82	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.80880245
83	detection of chemical stimulus involved in sensory perception of taste (GO:0050912)	2.80831733
84	muscle filament sliding (GO:0030049)	2.74356532
85	actin-myosin filament sliding (GO:0033275)	2.74356532
86	mechanosensory behavior (GO:0007638)	2.73683402
87	protein complex biogenesis (GO:0070271)	2.68815766
88	establishment of mitotic spindle localization (GO:0040001)	2.67371371
89	lung secretory cell differentiation (GO:0061140)	2.65954533
90	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.63736673
91	DNA demethylation (GO:0080111)	2.63090046
92	organelle fusion (GO:0048284)	2.61467383
93	musculoskeletal movement (GO:0050881)	2.60106629
94	multicellular organismal movement (GO:0050879)	2.60106629
95	protein targeting to ER (GO:0045047)	2.59561605
96	organelle membrane fusion (GO:0090174)	2.59108411
97	cotranslational protein targeting to membrane (GO:0006613)	2.59052360
98	postsynaptic membrane organization (GO:0001941)	2.58633719
99	DNA deamination (GO:0045006)	2.58584833
100	membrane budding (GO:0006900)	2.57878716

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	7.47656919
2	VDR_22108803_ChIP-Seq_LS180_Human	6.39022542
3	GATA1_22025678_ChIP-Seq_K562_Human	5.43508878
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.56489195
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.32960124
6	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.82538165
7	EZH2_22144423_ChIP-Seq_EOC_Human	2.76981759
8	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.54480231
9	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.54053331
10	YY1_21170310_ChIP-Seq_MESCs_Mouse	2.53707925
11	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.51311870
12	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.46428409
13	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.42691737
14	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	2.27134282
15	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	2.27134282
16	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	2.27134282
17	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.27087042
18	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.26252443
19	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.11129295
20	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.99152322
21	AR_21572438_ChIP-Seq_LNCaP_Human	1.94320305
22	IRF1_19129219_ChIP-ChIP_H3396_Human	1.80861955
23	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.75779428
24	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.73292957
25	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.69579514
26	TAF15_26573619_Chip-Seq_HEK293_Human	1.65151939
27	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.63911934
28	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.62746149
29	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.62023818
30	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.61815118
31	ELK1_19687146_ChIP-ChIP_HELA_Human	1.59723791
32	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.52909398
33	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.52850840
34	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.51936537
35	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.51240743
36	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.49994691
37	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.49750313
38	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.45677668
39	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.44969160
40	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.44799923
41	FUS_26573619_Chip-Seq_HEK293_Human	1.43776537
42	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.42877504
43	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.42877504
44	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.41293615
45	VDR_23849224_ChIP-Seq_CD4+_Human	1.41232599
46	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.38793494
47	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.36793871
48	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.30367812
49	ZIC3_20872845_ChIP-ChIP_MESCs_Mouse	1.25992831
50	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.21921157
51	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.20787071
52	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.19437347
53	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.19041713
54	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.16302249
55	TTF2_22483619_ChIP-Seq_HELA_Human	1.12631318
56	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.11518763
57	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.10073208
58	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.08683208
59	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.08520177
60	REST_21632747_ChIP-Seq_MESCs_Mouse	1.08175156
61	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.07737989
62	ZNF274_21170338_ChIP-Seq_K562_Hela	1.07337990
63	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.06749786
64	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.05559674
65	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.03562493
66	FOXP3_21729870_ChIP-Seq_TREG_Human	1.02247570
67	TP53_22573176_ChIP-Seq_HFKS_Human	1.01460154
68	P300_19829295_ChIP-Seq_ESCs_Human	1.01002705
69	BCAT_22108803_ChIP-Seq_LS180_Human	1.00444028
70	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.98814777
71	RXR_22108803_ChIP-Seq_LS180_Human	0.97642001
72	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	0.96879239
73	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.96482253
74	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	0.94672762
75	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.94393308
76	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.93125602
77	MYC_18358816_ChIP-ChIP_MESCs_Mouse	0.92245693
78	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.92143069
79	RNF2_18974828_ChIP-Seq_MESCs_Mouse	0.90596040
80	EZH2_18974828_ChIP-Seq_MESCs_Mouse	0.90596040
81	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	0.90322253
82	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.90134085
83	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.89981700
84	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	0.88708767
85	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.85845314
86	GBX2_23144817_ChIP-Seq_PC3_Human	0.84067006
87	SUZ12_27294783_Chip-Seq_ESCs_Mouse	0.84022236
88	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.82218326
89	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.81914817
90	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.80801954
91	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.77425294
92	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.77152419
93	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.76454941
94	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	0.75477048
95	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.75395204
96	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.75284194
97	GABP_19822575_ChIP-Seq_HepG2_Human	0.73979271
98	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.73159372
99	WDR5_24793694_ChIP-Seq_LNCAP_Human	0.72139188
100	RING1B_27294783_Chip-Seq_NPCs_Mouse	0.71420683

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000566_synostosis	9.02965935
2	MP0003303_peritoneal_inflammation	4.09326916
3	MP0002822_catalepsy	3.38165613
4	MP0008789_abnormal_olfactory_epithelium	3.12236975
5	MP0002751_abnormal_autonomic_nervous	2.56756022
6	MP0005499_abnormal_olfactory_system	2.42439238
7	MP0005394_taste/olfaction_phenotype	2.42439238
8	MP0000372_irregular_coat_pigmentation	2.33026067
9	MP0002876_abnormal_thyroid_physiology	2.16866629
10	MP0000383_abnormal_hair_follicle	2.13949704
11	MP0006072_abnormal_retinal_apoptosis	2.04820685
12	MP0003937_abnormal_limbs/digits/tail_de	2.03820846
13	MP0002102_abnormal_ear_morphology	2.00052577
14	MP0002138_abnormal_hepatobiliary_system	1.95739768
15	MP0004142_abnormal_muscle_tone	1.95201078
16	MP0001663_abnormal_digestive_system	1.88344219
17	MP0001664_abnormal_digestion	1.86704919
18	MP0006292_abnormal_olfactory_placode	1.83970374
19	MP0001919_abnormal_reproductive_system	1.74443476
20	MP0000049_abnormal_middle_ear	1.67159804
21	MP0000467_abnormal_esophagus_morphology	1.62182129
22	MP0002277_abnormal_respiratory_mucosa	1.59756291
23	MP0006082_CNS_inflammation	1.56906260
24	MP0010030_abnormal_orbit_morphology	1.55178850
25	MP0004885_abnormal_endolymph	1.53287743
26	MP0001529_abnormal_vocalization	1.53090656
27	MP0005423_abnormal_somatic_nervous	1.52024388
28	MP0005381_digestive/alimentary_phenotyp	1.48510653
29	MP0004145_abnormal_muscle_electrophysio	1.47786692
30	MP0001293_anophthalmia	1.46427693
31	MP0001968_abnormal_touch/_nociception	1.41221736
32	MP0002638_abnormal_pupillary_reflex	1.39282404
33	MP0003880_abnormal_central_pattern	1.28073941
34	MP0002184_abnormal_innervation	1.21360349
35	MP0000534_abnormal_ureter_morphology	1.20642632
36	MP0006276_abnormal_autonomic_nervous	1.19902507
37	MP0005389_reproductive_system_phenotype	1.19680104
38	MP0000778_abnormal_nervous_system	1.18689542
39	MP0001286_abnormal_eye_development	1.16479559
40	MP0009745_abnormal_behavioral_response	1.16100218
41	MP0010678_abnormal_skin_adnexa	1.13386564
42	MP0008058_abnormal_DNA_repair	1.10400715
43	MP0000631_abnormal_neuroendocrine_gland	1.10370654
44	MP0009379_abnormal_foot_pigmentation	1.10313034
45	MP0000537_abnormal_urethra_morphology	1.08478867
46	MP0003787_abnormal_imprinting	1.06471581
47	MP0004270_analgesia	1.05670259
48	MP0003115_abnormal_respiratory_system	1.04912539
49	MP0002095_abnormal_skin_pigmentation	1.03060448
50	MP0000428_abnormal_craniofacial_morphol	1.00612868
51	MP0005253_abnormal_eye_physiology	1.00418995
52	MP0002736_abnormal_nociception_after	0.99540369
53	MP0000026_abnormal_inner_ear	0.99227021
54	MP0001879_abnormal_lymphatic_vessel	0.98439918
55	MP0001486_abnormal_startle_reflex	0.93302415
56	MP0002735_abnormal_chemical_nociception	0.92635160
57	MP0003315_abnormal_perineum_morphology	0.92433119
58	MP0002734_abnormal_mechanical_nocicepti	0.91319287
59	MP0001440_abnormal_grooming_behavior	0.90883964
60	MP0008877_abnormal_DNA_methylation	0.90806484
61	MP0002733_abnormal_thermal_nociception	0.89931777
62	MP0001502_abnormal_circadian_rhythm	0.89865963
63	MP0000747_muscle_weakness	0.89140529
64	MP0001905_abnormal_dopamine_level	0.87870964
65	MP0004036_abnormal_muscle_relaxation	0.86834617
66	MP0002210_abnormal_sex_determination	0.84986370
67	MP0002272_abnormal_nervous_system	0.83933440
68	MP0000955_abnormal_spinal_cord	0.82532658
69	MP0005083_abnormal_biliary_tract	0.82372424
70	MP0001485_abnormal_pinna_reflex	0.81723896
71	MP0003635_abnormal_synaptic_transmissio	0.81289597
72	MP0002752_abnormal_somatic_nervous	0.80396270
73	MP0005084_abnormal_gallbladder_morpholo	0.80060836
74	MP0002163_abnormal_gland_morphology	0.79464814
75	MP0005377_hearing/vestibular/ear_phenot	0.79104739
76	MP0003878_abnormal_ear_physiology	0.79104739
77	MP0008872_abnormal_physiological_respon	0.78643002
78	MP0001873_stomach_inflammation	0.78372099
79	MP0002233_abnormal_nose_morphology	0.78213414
80	MP0003942_abnormal_urinary_system	0.77282387
81	MP0002109_abnormal_limb_morphology	0.77140394
82	MP0003136_yellow_coat_color	0.76820504
83	MP0009250_abnormal_appendicular_skeleto	0.76098166
84	MP0001348_abnormal_lacrimal_gland	0.75002814
85	MP0001963_abnormal_hearing_physiology	0.73390865
86	MP0001986_abnormal_taste_sensitivity	0.71801258
87	MP0001970_abnormal_pain_threshold	0.71064529
88	MP0003959_abnormal_lean_body	0.69457598
89	MP0004133_heterotaxia	0.67611664
90	MP0002572_abnormal_emotion/affect_behav	0.67137683
91	MP0003935_abnormal_craniofacial_develop	0.66908355
92	MP0000749_muscle_degeneration	0.66775889
93	MP0003123_paternal_imprinting	0.65385841
94	MP0002938_white_spotting	0.64467126
95	MP0004811_abnormal_neuron_physiology	0.64293041
96	MP0001915_intracranial_hemorrhage	0.64176288
97	MP0002837_dystrophic_cardiac_calcinosis	0.64043852
98	MP0001984_abnormal_olfaction	0.63480704
99	MP0003122_maternal_imprinting	0.63157265
100	MP0005551_abnormal_eye_electrophysiolog	0.62275787

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	5.80149731
2	Duplicated collecting system (HP:0000081)	4.76332215
3	Abnormality of the renal collecting system (HP:0004742)	4.63225032
4	Large for gestational age (HP:0001520)	4.51559510
5	Adactyly (HP:0009776)	4.48273529
6	Hypoplastic pelvis (HP:0008839)	4.42640974
7	Long foot (HP:0001833)	4.32600893
8	Broad-based gait (HP:0002136)	3.81176431
9	Palpebral edema (HP:0100540)	3.66196952
10	Abnormality of the phalanges of the 2nd finger (HP:0009541)	3.51345447
11	Dry hair (HP:0011359)	3.34322009
12	Acute lymphatic leukemia (HP:0006721)	3.26605071
13	Acute necrotizing encephalopathy (HP:0006965)	3.23236226
14	Severe muscular hypotonia (HP:0006829)	3.21370208
15	Stenosis of the external auditory canal (HP:0000402)	3.15058768
16	Reduced subcutaneous adipose tissue (HP:0003758)	3.04511155
17	Septo-optic dysplasia (HP:0100842)	2.97885360
18	Increased number of teeth (HP:0011069)	2.87427522
19	Menstrual irregularities (HP:0000858)	2.86850533
20	Abnormality of fatty-acid metabolism (HP:0004359)	2.78821770
21	Progressive muscle weakness (HP:0003323)	2.76370309
22	Mitochondrial inheritance (HP:0001427)	2.75189650
23	Abnormal mitochondria in muscle tissue (HP:0008316)	2.75121356
24	Absent septum pellucidum (HP:0001331)	2.73746060
25	Abnormality of the labia minora (HP:0012880)	2.69386378
26	Brushfield spots (HP:0001088)	2.66019522
27	Progressive macrocephaly (HP:0004481)	2.65236677
28	Pulmonary artery stenosis (HP:0004415)	2.58636608
29	Acute encephalopathy (HP:0006846)	2.49799565
30	Pancreatic cysts (HP:0001737)	2.49405140
31	Autoamputation (HP:0001218)	2.43317961
32	Hypoplastic nipples (HP:0002557)	2.41105339
33	Chorioretinal coloboma (HP:0000567)	2.39739175
34	3-Methylglutaconic aciduria (HP:0003535)	2.37428096
35	Increased CSF lactate (HP:0002490)	2.34543630
36	Decreased lacrimation (HP:0000633)	2.34543278
37	Myoglobinuria (HP:0002913)	2.29416886
38	Reticulocytopenia (HP:0001896)	2.26139757
39	Congenital stationary night blindness (HP:0007642)	2.25585559
40	Abnormal auditory evoked potentials (HP:0006958)	2.25550336
41	Anhidrosis (HP:0000970)	2.25069579
42	Decreased muscle mass (HP:0003199)	2.23965829
43	Ureteral stenosis (HP:0000071)	2.23863672
44	Abnormality of the septum pellucidum (HP:0007375)	2.22594105
45	Lactic acidosis (HP:0003128)	2.22067785
46	Wide intermamillary distance (HP:0006610)	2.19621524
47	Hepatocellular necrosis (HP:0001404)	2.16005681
48	Hypoplastic iliac wings (HP:0002866)	2.15356411
49	Calcaneovalgus deformity (HP:0001848)	2.11486982
50	Pancreatic fibrosis (HP:0100732)	2.10496067
51	Colon cancer (HP:0003003)	2.09971804
52	Congenital, generalized hypertrichosis (HP:0004540)	2.09141012
53	Absent phalangeal crease (HP:0006109)	2.08059248
54	Ureteral duplication (HP:0000073)	2.07468965
55	Exercise intolerance (HP:0003546)	2.06892442
56	Abnormality of the parietal bone (HP:0002696)	2.06364285
57	Deformed tarsal bones (HP:0008119)	2.05399987
58	Abnormality of cells of the erythroid lineage (HP:0012130)	2.05285017
59	Abnormality of the 2nd finger (HP:0004100)	2.05187715
60	Delayed CNS myelination (HP:0002188)	2.02022480
61	Depressed nasal ridge (HP:0000457)	2.00082273
62	Sudden death (HP:0001699)	1.99513645
63	Ureteral obstruction (HP:0006000)	1.98747223
64	Anxiety (HP:0000739)	1.98267372
65	Abnormal ventriculo-arterial connection (HP:0011563)	1.91282928
66	Transposition of the great arteries (HP:0001669)	1.91282928
67	Abnormal connection of the cardiac segments (HP:0011545)	1.91282928
68	Sleep apnea (HP:0010535)	1.90958243
69	Increased hepatocellular lipid droplets (HP:0006565)	1.88596633
70	Fibular aplasia (HP:0002990)	1.86280632
71	Hepatic necrosis (HP:0002605)	1.84888514
72	Polymicrogyria (HP:0002126)	1.84686782
73	Optic disc pallor (HP:0000543)	1.83711387
74	Abnormal rod and cone electroretinograms (HP:0008323)	1.83095679
75	Hypoventilation (HP:0002791)	1.83060320
76	Increased serum lactate (HP:0002151)	1.83010380
77	Nemaline bodies (HP:0003798)	1.83009553
78	Optic nerve hypoplasia (HP:0000609)	1.82551794
79	Abnormality of the middle phalanges of the toes (HP:0010183)	1.81329888
80	Maternal diabetes (HP:0009800)	1.79642244
81	Distal arthrogryposis (HP:0005684)	1.78388588
82	Spastic tetraplegia (HP:0002510)	1.77633634
83	Widely spaced teeth (HP:0000687)	1.77471315
84	Myokymia (HP:0002411)	1.76815948
85	Mask-like facies (HP:0000298)	1.76779605
86	Molar tooth sign on MRI (HP:0002419)	1.76757521
87	Abnormality of midbrain morphology (HP:0002418)	1.76757521
88	Steatorrhea (HP:0002570)	1.73349113
89	Round ear (HP:0100830)	1.73005498
90	2-3 toe syndactyly (HP:0004691)	1.70930707
91	True hermaphroditism (HP:0010459)	1.70910486
92	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.69001082
93	Respiratory failure (HP:0002878)	1.68129941
94	Symphalangism affecting the phalanges of the hand (HP:0009773)	1.66885311
95	Synostosis involving the elbow (HP:0003938)	1.65299409
96	Humeroradial synostosis (HP:0003041)	1.65299409
97	Overfolded helix (HP:0000396)	1.63561718
98	Abnormal number of erythroid precursors (HP:0012131)	1.63279428
99	Rhabdomyolysis (HP:0003201)	1.63275183
100	Exercise-induced muscle cramps (HP:0003710)	1.62498551

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MKNK1	5.87193731
2	TAOK1	4.29908335
3	TAOK2	4.25098921
4	MAP3K11	3.32463158
5	MAP3K3	2.83349286
6	MAP2K3	2.45355129
7	TIE1	2.28415990
8	MKNK2	10.0610229
9	PHKG1	1.84765987
10	PHKG2	1.84765987
11	DYRK1A	1.76636721
12	JAK3	1.73532807
13	ABL2	1.69018086
14	SRPK1	1.65867698
15	VRK2	1.39829884
16	TXK	1.39357050
17	WNK4	1.23212101
18	EPHB2	1.12839595
19	FGFR2	1.12799778
20	TSSK6	1.11976993
21	TRIM28	1.08694529
22	NME2	1.07793545
23	TLK1	1.06946354
24	TNIK	1.03317616
25	DYRK2	1.01363913
26	WNK3	0.99552884
27	MAP3K12	0.94714716
28	CASK	0.92423189
29	CHEK2	0.90925516
30	ZAK	0.87996167
31	NUAK1	0.87276604
32	STK16	0.84674570
33	MARK1	0.77850021
34	MAP3K5	0.77165203
35	STK39	0.70837437
36	TAF1	0.69543335
37	OBSCN	0.69319258
38	BUB1	0.68243931
39	INSRR	0.68158667
40	VRK1	0.65122391
41	GRK1	0.58105984
42	MOS	0.55562936
43	CSNK1G2	0.54495570
44	TYRO3	0.53784507
45	MAP3K1	0.52087937
46	BMPR1B	0.51352272
47	AURKA	0.48375279
48	BCKDK	0.47433433
49	PLK3	0.47147421
50	BCR	0.44928250
51	CDK8	0.43358486
52	WNK1	0.43297993
53	PRKCQ	0.43258700
54	PAK6	0.43106089
55	PRKD3	0.41981643
56	MST4	0.40687891
57	MAP3K8	0.40645246
58	MAPK13	0.40464095
59	CCNB1	0.37723487
60	ADRBK2	0.35419441
61	CSNK1G3	0.35388998
62	EIF2AK3	0.34828611
63	MAP4K2	0.34398073
64	CSNK1A1	0.33259979
65	PLK2	0.32179634
66	CSNK1G1	0.31759031
67	MINK1	0.31490826
68	CSNK1A1L	0.30120283
69	PRKCE	0.29859260
70	IRAK1	0.27335920
71	LIMK1	0.25156435
72	CSNK2A1	0.24875985
73	NTRK2	0.24677278
74	CSNK2A2	0.24109923
75	PRKCG	0.23165262
76	MUSK	0.22532369
77	OXSR1	0.20795048
78	PINK1	0.20607416
79	EPHA3	0.20603900
80	CAMKK2	0.19830736
81	PIK3CA	0.19534967
82	FGFR1	0.19215439
83	TEC	0.19192095
84	SGK494	0.18476696
85	SGK223	0.18476696
86	NME1	0.18464072
87	PRKG1	0.17725880
88	SIK3	0.16655892
89	PRKACA	0.16197059
90	CSNK1E	0.15656214
91	FRK	0.15467233
92	RPS6KA5	0.15459875
93	DAPK3	0.14195883
94	NLK	0.13998933
95	NEK1	0.13640755
96	TESK1	0.12306588
97	NEK9	0.11066247
98	EPHA4	0.09775518
99	CDK9	0.09107489
100	PRKCD	0.08816533

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.62836029
2	Proteasome_Homo sapiens_hsa03050	4.47539696
3	RNA polymerase_Homo sapiens_hsa03020	3.89446410
4	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	3.81638318
5	Oxidative phosphorylation_Homo sapiens_hsa00190	3.15989973
6	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	2.93105180
7	Parkinsons disease_Homo sapiens_hsa05012	2.73339672
8	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.44770289
9	Huntingtons disease_Homo sapiens_hsa05016	2.26786631
10	Cardiac muscle contraction_Homo sapiens_hsa04260	2.18033375
11	Alzheimers disease_Homo sapiens_hsa05010	1.91671938
12	Protein export_Homo sapiens_hsa03060	1.86391212
13	Taste transduction_Homo sapiens_hsa04742	1.80693663
14	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.73647034
15	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.47177072
16	Nicotine addiction_Homo sapiens_hsa05033	1.43692142
17	Nitrogen metabolism_Homo sapiens_hsa00910	1.42298800
18	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.34394928
19	RNA transport_Homo sapiens_hsa03013	1.32201218
20	Butanoate metabolism_Homo sapiens_hsa00650	1.30714506
21	Phototransduction_Homo sapiens_hsa04744	1.29044855
22	Basal transcription factors_Homo sapiens_hsa03022	1.27264644
23	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.27149329
24	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.26226736
25	Nucleotide excision repair_Homo sapiens_hsa03420	1.23136681
26	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.22012285
27	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.20844437
28	RNA degradation_Homo sapiens_hsa03018	1.20609986
29	Spliceosome_Homo sapiens_hsa03040	1.18464606
30	Tight junction_Homo sapiens_hsa04530	1.17751148
31	One carbon pool by folate_Homo sapiens_hsa00670	1.15980211
32	Morphine addiction_Homo sapiens_hsa05032	1.10653590
33	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.08172485
34	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.04297107
35	Pyrimidine metabolism_Homo sapiens_hsa00240	1.00441073
36	Fatty acid elongation_Homo sapiens_hsa00062	0.99426686
37	Mismatch repair_Homo sapiens_hsa03430	0.96957410
38	Insulin secretion_Homo sapiens_hsa04911	0.90262443
39	Propanoate metabolism_Homo sapiens_hsa00640	0.88793094
40	Dopaminergic synapse_Homo sapiens_hsa04728	0.87429875
41	GABAergic synapse_Homo sapiens_hsa04727	0.84711731
42	Purine metabolism_Homo sapiens_hsa00230	0.80506494
43	Basal cell carcinoma_Homo sapiens_hsa05217	0.79407809
44	Cholinergic synapse_Homo sapiens_hsa04725	0.76932683
45	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.75884653
46	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.73809215
47	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.72858164
48	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.71922645
49	Folate biosynthesis_Homo sapiens_hsa00790	0.70991556
50	Fanconi anemia pathway_Homo sapiens_hsa03460	0.70563905
51	Tryptophan metabolism_Homo sapiens_hsa00380	0.68645248
52	Asthma_Homo sapiens_hsa05310	0.66970801
53	Wnt signaling pathway_Homo sapiens_hsa04310	0.65590885
54	Serotonergic synapse_Homo sapiens_hsa04726	0.64010272
55	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.63877432
56	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.61066393
57	Lysine degradation_Homo sapiens_hsa00310	0.59909634
58	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.58525376
59	Linoleic acid metabolism_Homo sapiens_hsa00591	0.58044340
60	Cocaine addiction_Homo sapiens_hsa05030	0.57727893
61	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.56528783
62	Peroxisome_Homo sapiens_hsa04146	0.55496970
63	Circadian entrainment_Homo sapiens_hsa04713	0.53652424
64	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.52080926
65	Glutathione metabolism_Homo sapiens_hsa00480	0.51507082
66	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.51205630
67	mRNA surveillance pathway_Homo sapiens_hsa03015	0.50887132
68	Chemical carcinogenesis_Homo sapiens_hsa05204	0.50459754
69	Glutamatergic synapse_Homo sapiens_hsa04724	0.50332156
70	beta-Alanine metabolism_Homo sapiens_hsa00410	0.50135242
71	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.48997802
72	Oocyte meiosis_Homo sapiens_hsa04114	0.45937746
73	Alcoholism_Homo sapiens_hsa05034	0.45088964
74	Homologous recombination_Homo sapiens_hsa03440	0.44821626
75	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.44315839
76	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.43214626
77	Arginine biosynthesis_Homo sapiens_hsa00220	0.41856947
78	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.41756643
79	Collecting duct acid secretion_Homo sapiens_hsa04966	0.40970878
80	Hippo signaling pathway_Homo sapiens_hsa04390	0.40317834
81	Axon guidance_Homo sapiens_hsa04360	0.39885530
82	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.39766216
83	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.38236825
84	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.38214656
85	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.37562740
86	Gastric acid secretion_Homo sapiens_hsa04971	0.36340747
87	MAPK signaling pathway_Homo sapiens_hsa04010	0.35624309
88	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.34553046
89	Olfactory transduction_Homo sapiens_hsa04740	0.34097200
90	Circadian rhythm_Homo sapiens_hsa04710	0.33938927
91	Salivary secretion_Homo sapiens_hsa04970	0.33692544
92	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.33683307
93	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.33547110
94	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.32274831
95	Amphetamine addiction_Homo sapiens_hsa05031	0.31636093
96	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.31449436
97	Retinol metabolism_Homo sapiens_hsa00830	0.29882301
98	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.29790341
99	Mineral absorption_Homo sapiens_hsa04978	0.29560283
100	Metabolic pathways_Homo sapiens_hsa01100	0.29495244

GAPDHP63

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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