ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of mitotic sister chromatid separation (GO:1901970)	9.95670111
2	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	9.95670111
3	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	9.95670111
4	negative regulation of Ras GTPase activity (GO:0034261)	9.42600912
5	eosinophil chemotaxis (GO:0048245)	8.79064109
6	negative regulation of T cell receptor signaling pathway (GO:0050860)	8.53226520
7	ribosomal small subunit assembly (GO:0000028)	8.43207535
8	eosinophil migration (GO:0072677)	7.94144024
9	fucose catabolic process (GO:0019317)	7.84955142
10	L-fucose metabolic process (GO:0042354)	7.84955142
11	L-fucose catabolic process (GO:0042355)	7.84955142
12	regulation of sister chromatid cohesion (GO:0007063)	7.74966143
13	regulation of mononuclear cell migration (GO:0071675)	6.96563041
14	negative regulation of peptidyl-threonine phosphorylation (GO:0010801)	6.91748573
15	negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)	6.56971590
16	negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)	6.52772427
17	positive regulation of chromosome segregation (GO:0051984)	6.49327456
18	branch elongation of an epithelium (GO:0060602)	6.48928798
19	coenzyme A biosynthetic process (GO:0015937)	6.23901613
20	vesicle fusion (GO:0006906)	6.18287808
21	autophagic vacuole fusion (GO:0000046)	5.65302723
22	macrophage chemotaxis (GO:0048246)	5.39360073
23	peptidyl-lysine dimethylation (GO:0018027)	5.35987087
24	organ growth (GO:0035265)	5.22428487
25	protein import into peroxisome matrix (GO:0016558)	5.16719683
26	regulation of T cell receptor signaling pathway (GO:0050856)	5.14540879
27	double-strand break repair via nonhomologous end joining (GO:0006303)	5.10329912
28	non-recombinational repair (GO:0000726)	5.10329912
29	proteasome assembly (GO:0043248)	4.98078293
30	positive regulation of calcium ion import (GO:0090280)	4.94242848
31	organelle membrane fusion (GO:0090174)	4.86962031
32	localization within membrane (GO:0051668)	4.76574743
33	axis elongation (GO:0003401)	4.49718994
34	regulation of beta-amyloid formation (GO:1902003)	4.46477003
35	regulation of nitric-oxide synthase biosynthetic process (GO:0051769)	4.43253775
36	monocyte chemotaxis (GO:0002548)	4.40933860
37	preassembly of GPI anchor in ER membrane (GO:0016254)	4.39297545
38	fucosylation (GO:0036065)	4.37357152
39	oxidative demethylation (GO:0070989)	4.36500807
40	negative regulation of GTP catabolic process (GO:0033125)	4.29516714
41	negative regulation of GTPase activity (GO:0034260)	4.29516714
42	detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)	4.28739329
43	establishment of mitotic spindle orientation (GO:0000132)	4.23715977
44	seminiferous tubule development (GO:0072520)	4.12894601
45	fucose metabolic process (GO:0006004)	4.11562823
46	pantothenate metabolic process (GO:0015939)	4.00752608
47	metallo-sulfur cluster assembly (GO:0031163)	3.97895824
48	iron-sulfur cluster assembly (GO:0016226)	3.97895824
49	organelle fusion (GO:0048284)	3.93598842
50	negative regulation of circadian rhythm (GO:0042754)	3.92107477
51	acrosome assembly (GO:0001675)	3.91836040
52	regulation of autophagic vacuole assembly (GO:2000785)	3.90735300
53	coenzyme A metabolic process (GO:0015936)	3.82815362
54	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	3.80667815
55	detection of chemical stimulus involved in sensory perception of taste (GO:0050912)	3.78567319
56	positive chemotaxis (GO:0050918)	3.77409936
57	purine nucleoside bisphosphate biosynthetic process (GO:0034033)	3.76006142
58	ribonucleoside bisphosphate biosynthetic process (GO:0034030)	3.76006142
59	nucleoside bisphosphate biosynthetic process (GO:0033866)	3.76006142
60	establishment of mitotic spindle localization (GO:0040001)	3.75954814
61	protein localization to peroxisome (GO:0072662)	3.72432588
62	protein targeting to peroxisome (GO:0006625)	3.72432588
63	establishment of protein localization to peroxisome (GO:0072663)	3.72432588
64	telomere maintenance via recombination (GO:0000722)	3.69651954
65	histone H3-K9 methylation (GO:0051567)	3.64251200
66	DNA demethylation (GO:0080111)	3.60229899
67	intracellular protein transmembrane import (GO:0044743)	3.57512068
68	regulation of antigen receptor-mediated signaling pathway (GO:0050854)	3.49448283
69	regulation of amyloid precursor protein catabolic process (GO:1902991)	3.45664780
70	membrane budding (GO:0006900)	3.45320465
71	establishment of spindle orientation (GO:0051294)	3.44661196
72	regulation of fibroblast growth factor receptor signaling pathway (GO:0040036)	3.35849124
73	single-organism membrane fusion (GO:0044801)	3.35517710
74	peroxisomal transport (GO:0043574)	3.31429116
75	regulation of stem cell maintenance (GO:2000036)	3.27527288
76	GPI anchor biosynthetic process (GO:0006506)	3.20865396
77	regulation of vacuole organization (GO:0044088)	3.16615115
78	DNA integration (GO:0015074)	3.13635026
79	mitochondrial RNA metabolic process (GO:0000959)	3.13625800
80	negative regulation of macroautophagy (GO:0016242)	3.09924263
81	mitotic recombination (GO:0006312)	3.08614959
82	RNA methylation (GO:0001510)	3.08214400
83	ER to Golgi vesicle-mediated transport (GO:0006888)	3.05714985
84	imidazole-containing compound metabolic process (GO:0052803)	3.04373416
85	folic acid-containing compound biosynthetic process (GO:0009396)	3.03728894
86	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.00987532
87	termination of RNA polymerase III transcription (GO:0006386)	3.00987532
88	GPI anchor metabolic process (GO:0006505)	2.98345068
89	protein sumoylation (GO:0016925)	2.94361189
90	protein targeting to lysosome (GO:0006622)	2.93374357
91	establishment of protein localization to vacuole (GO:0072666)	2.93374357
92	protein targeting to vacuole (GO:0006623)	2.93374357
93	DNA dealkylation (GO:0035510)	2.93116732
94	ATP synthesis coupled proton transport (GO:0015986)	2.87230872
95	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.87230872
96	sodium-independent organic anion transport (GO:0043252)	2.86130723
97	3-UTR-mediated mRNA stabilization (GO:0070935)	2.83876978
98	negative regulation of nucleoside metabolic process (GO:0045978)	2.78933312
99	protein prenylation (GO:0018342)	10.8250634
100	prenylation (GO:0097354)	10.8250634

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	8.05036190
2	GATA1_22025678_ChIP-Seq_K562_Human	7.02158057
3	VDR_22108803_ChIP-Seq_LS180_Human	5.80471930
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.23329148
5	NOTCH1_21737748_ChIP-Seq_TLL_Human	3.99109502
6	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.62288856
7	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.54606781
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.84172667
9	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.83171240
10	YY1_21170310_ChIP-Seq_MESCs_Mouse	2.70677193
11	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.56110441
12	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.49391165
13	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.46108784
14	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.45650985
15	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.41928549
16	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.40792088
17	AR_21572438_ChIP-Seq_LNCaP_Human	2.20297084
18	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.09911437
19	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.07937692
20	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.02938399
21	ZNF274_21170338_ChIP-Seq_K562_Hela	1.96641877
22	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.89617288
23	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.88670338
24	VDR_23849224_ChIP-Seq_CD4+_Human	1.83112021
25	IRF1_19129219_ChIP-ChIP_H3396_Human	1.81476960
26	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.79733999
27	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.75176914
28	ELK1_19687146_ChIP-ChIP_HELA_Human	1.65503649
29	ZIC3_20872845_ChIP-ChIP_MESCs_Mouse	1.54528218
30	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.53730227
31	TAF15_26573619_Chip-Seq_HEK293_Human	1.42233392
32	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.37695587
33	BCAT_22108803_ChIP-Seq_LS180_Human	1.36934657
34	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.36727545
35	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.29142037
36	FOXP3_21729870_ChIP-Seq_TREG_Human	1.28733127
37	FUS_26573619_Chip-Seq_HEK293_Human	1.26859479
38	TP53_22573176_ChIP-Seq_HFKS_Human	1.25762296
39	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.25411110
40	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.25411110
41	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.24407927
42	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.23625763
43	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.22978704
44	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.16257457
45	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.15124963
46	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.15116848
47	RXR_22108803_ChIP-Seq_LS180_Human	1.14292358
48	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.12972628
49	GATA3_26560356_Chip-Seq_TH1_Human	1.12753812
50	ZNF263_19887448_ChIP-Seq_K562_Human	1.12350736
51	GABP_19822575_ChIP-Seq_HepG2_Human	1.11192888
52	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.09817008
53	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.08707522
54	P300_19829295_ChIP-Seq_ESCs_Human	1.06441315
55	GBX2_23144817_ChIP-Seq_PC3_Human	1.05013016
56	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.04696918
57	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.01963671
58	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.01963671
59	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.01558245
60	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.00585409
61	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.00312759
62	TTF2_22483619_ChIP-Seq_HELA_Human	0.99094777
63	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	0.97048268
64	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.95022088
65	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.89740734
66	DCP1A_22483619_ChIP-Seq_HELA_Human	0.88741889
67	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.88353705
68	NANOG_19829295_ChIP-Seq_ESCs_Human	0.88166667
69	SOX2_19829295_ChIP-Seq_ESCs_Human	0.88166667
70	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	0.86995765
71	TCF4_22108803_ChIP-Seq_LS180_Human	0.86270394
72	STAT3_1855785_ChIP-Seq_MESCs_Mouse	0.86126322
73	HTT_18923047_ChIP-ChIP_STHdh_Human	0.85885457
74	ERG_20517297_ChIP-Seq_VCAP_Human	0.85511546
75	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.84963883
76	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	0.82909593
77	EZH2_22144423_ChIP-Seq_EOC_Human	0.82621188
78	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.82235587
79	NANOG_20526341_ChIP-Seq_ESCs_Human	0.81181252
80	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.81174385
81	AR_20517297_ChIP-Seq_VCAP_Human	0.79809974
82	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.79245028
83	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.78265747
84	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.77286453
85	MYC_18940864_ChIP-ChIP_HL60_Human	0.76177867
86	GATA3_21867929_ChIP-Seq_TH1_Mouse	0.76135306
87	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.76067858
88	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	0.74439501
89	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.72494994
90	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.72353258
91	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.72338548
92	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.70445397
93	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.69772003
94	WDR5_24793694_ChIP-Seq_LNCAP_Human	0.69338394
95	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.69032453
96	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.66553807
97	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.66171760
98	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.65237013
99	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.64753921
100	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.64582748

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003303_peritoneal_inflammation	7.49575395
2	MP0006082_CNS_inflammation	4.66046494
3	MP0001663_abnormal_digestive_system	2.95557453
4	MP0001919_abnormal_reproductive_system	2.85921537
5	MP0002751_abnormal_autonomic_nervous	2.64532238
6	MP0001664_abnormal_digestion	2.62642693
7	MP0000467_abnormal_esophagus_morphology	2.60125476
8	MP0000383_abnormal_hair_follicle	2.16930580
9	MP0005381_digestive/alimentary_phenotyp	2.15832469
10	MP0001293_anophthalmia	2.12292776
11	MP0005389_reproductive_system_phenotype	2.01851348
12	MP0000566_synostosis	11.0746991
13	MP0003115_abnormal_respiratory_system	1.84950609
14	MP0002876_abnormal_thyroid_physiology	1.80436149
15	MP0003937_abnormal_limbs/digits/tail_de	1.66722659
16	MP0003195_calcinosis	1.51230476
17	MP0008058_abnormal_DNA_repair	1.50920141
18	MP0005166_decreased_susceptibility_to	1.44358163
19	MP0000372_irregular_coat_pigmentation	1.43597141
20	MP0001286_abnormal_eye_development	1.41818365
21	MP0001986_abnormal_taste_sensitivity	1.31632726
22	MP0010678_abnormal_skin_adnexa	1.26650134
23	MP0006292_abnormal_olfactory_placode	1.21832907
24	MP0001764_abnormal_homeostasis	1.21337022
25	MP0006072_abnormal_retinal_apoptosis	1.17916596
26	MP0005253_abnormal_eye_physiology	1.14757711
27	MP0000534_abnormal_ureter_morphology	1.10407387
28	MP0008875_abnormal_xenobiotic_pharmacok	1.10364336
29	MP0008877_abnormal_DNA_methylation	1.08436544
30	MP0000358_abnormal_cell_content/	1.08054016
31	MP0003136_yellow_coat_color	1.07729578
32	MP0001963_abnormal_hearing_physiology	1.05685467
33	MP0000428_abnormal_craniofacial_morphol	1.04033977
34	MP0006276_abnormal_autonomic_nervous	1.03495342
35	MP0002277_abnormal_respiratory_mucosa	1.02923007
36	MP0000026_abnormal_inner_ear	1.01596239
37	MP0000490_abnormal_crypts_of	1.00190119
38	MP0005084_abnormal_gallbladder_morpholo	0.99688119
39	MP0001915_intracranial_hemorrhage	0.96830795
40	MP0002102_abnormal_ear_morphology	0.96815328
41	MP0008872_abnormal_physiological_respon	0.96508890
42	MP0002938_white_spotting	0.95514684
43	MP0001485_abnormal_pinna_reflex	0.95439882
44	MP0005377_hearing/vestibular/ear_phenot	0.92750998
45	MP0003878_abnormal_ear_physiology	0.92750998
46	MP0002019_abnormal_tumor_incidence	0.92698016
47	MP0002163_abnormal_gland_morphology	0.90736551
48	MP0002210_abnormal_sex_determination	0.89545789
49	MP0005075_abnormal_melanosome_morpholog	0.89513389
50	MP0002109_abnormal_limb_morphology	0.88644214
51	MP0002736_abnormal_nociception_after	0.88322381
52	MP0001529_abnormal_vocalization	0.87765605
53	MP0004885_abnormal_endolymph	0.86877581
54	MP0001968_abnormal_touch/_nociception	0.86742158
55	MP0002837_dystrophic_cardiac_calcinosis	0.86023419
56	MP0003942_abnormal_urinary_system	0.85166538
57	MP0003011_delayed_dark_adaptation	0.81780250
58	MP0005501_abnormal_skin_physiology	0.81205370
59	MP0004142_abnormal_muscle_tone	0.77893562
60	MP0005551_abnormal_eye_electrophysiolog	0.76463013
61	MP0002184_abnormal_innervation	0.75434715
62	MP0005645_abnormal_hypothalamus_physiol	0.73471400
63	MP0002638_abnormal_pupillary_reflex	0.72092862
64	MP0002735_abnormal_chemical_nociception	0.71661633
65	MP0004742_abnormal_vestibular_system	0.70306952
66	MP0005379_endocrine/exocrine_gland_phen	0.69254460
67	MP0005391_vision/eye_phenotype	0.69098050
68	MP0003936_abnormal_reproductive_system	0.68787741
69	MP0005423_abnormal_somatic_nervous	0.68496398
70	MP0001984_abnormal_olfaction	0.67878949
71	MP0003567_abnormal_fetal_cardiomyocyte	0.67253367
72	MP0005408_hypopigmentation	0.67114836
73	MP0005332_abnormal_amino_acid	0.64490948
74	MP0002234_abnormal_pharynx_morphology	0.64061264
75	MP0003122_maternal_imprinting	0.63916931
76	MP0003880_abnormal_central_pattern	0.62291926
77	MP0009379_abnormal_foot_pigmentation	0.62137821
78	MP0003763_abnormal_thymus_physiology	0.60840719
79	MP0004145_abnormal_muscle_electrophysio	0.60699432
80	MP0002752_abnormal_somatic_nervous	0.60674962
81	MP0005197_abnormal_uvea_morphology	0.60315379
82	MP0005195_abnormal_posterior_eye	0.58364778
83	MP0000470_abnormal_stomach_morphology	0.56429194
84	MP0004147_increased_porphyrin_level	0.55849910
85	MP0004133_heterotaxia	0.55831857
86	MP0003638_abnormal_response/metabolism_	0.53924406
87	MP0002115_abnormal_skeleton_extremities	0.52996582
88	MP0009763_increased_sensitivity_to	0.51225808
89	MP0005671_abnormal_response_to	0.51055285
90	MP0002272_abnormal_nervous_system	0.50473433
91	MP0010155_abnormal_intestine_physiology	0.50424683
92	MP0003186_abnormal_redox_activity	0.49577563
93	MP0000049_abnormal_middle_ear	0.47359106
94	MP0003077_abnormal_cell_cycle	0.47301851
95	MP0003453_abnormal_keratinocyte_physiol	0.46744283
96	MP0009745_abnormal_behavioral_response	0.46125304
97	MP0003121_genomic_imprinting	0.44731839
98	MP0003646_muscle_fatigue	0.43891638
99	MP0008789_abnormal_olfactory_epithelium	0.43527508
100	MP0001905_abnormal_dopamine_level	0.42988361

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	9.39248609
2	Duplicated collecting system (HP:0000081)	7.80892637
3	Abnormality of the renal collecting system (HP:0004742)	7.03133616
4	Large for gestational age (HP:0001520)	6.65324918
5	Long foot (HP:0001833)	6.55681972
6	Adactyly (HP:0009776)	5.34103311
7	Hypoplastic pelvis (HP:0008839)	5.18002185
8	Abnormality of fatty-acid metabolism (HP:0004359)	4.91160817
9	Acute lymphatic leukemia (HP:0006721)	4.82746850
10	Dry hair (HP:0011359)	4.60282515
11	Brushfield spots (HP:0001088)	4.55893601
12	Progressive muscle weakness (HP:0003323)	4.46997977
13	Autoamputation (HP:0001218)	4.31468766
14	Ureteral duplication (HP:0000073)	4.19990438
15	Severe muscular hypotonia (HP:0006829)	3.67716184
16	Steatorrhea (HP:0002570)	3.65284558
17	Ureteral stenosis (HP:0000071)	3.57713606
18	Broad-based gait (HP:0002136)	3.48259274
19	Hypoplastic nipples (HP:0002557)	3.44926058
20	Pulmonary artery stenosis (HP:0004415)	3.40570893
21	Ureteral obstruction (HP:0006000)	3.24786278
22	Abnormal auditory evoked potentials (HP:0006958)	3.23306998
23	Menstrual irregularities (HP:0000858)	3.17089761
24	Acute necrotizing encephalopathy (HP:0006965)	2.86090802
25	Increased number of teeth (HP:0011069)	2.84166736
26	Decreased muscle mass (HP:0003199)	2.81373631
27	Lactic acidosis (HP:0003128)	2.79073832
28	Anhidrosis (HP:0000970)	2.76761039
29	Transposition of the great arteries (HP:0001669)	2.76047009
30	Abnormal connection of the cardiac segments (HP:0011545)	2.76047009
31	Abnormal ventriculo-arterial connection (HP:0011563)	2.76047009
32	Reduced subcutaneous adipose tissue (HP:0003758)	2.73162556
33	Sudden death (HP:0001699)	2.71481502
34	Clubbing of toes (HP:0100760)	2.70427573
35	Fat malabsorption (HP:0002630)	2.69977409
36	Wide intermamillary distance (HP:0006610)	2.64580169
37	Myoglobinuria (HP:0002913)	2.63207850
38	Epiphyseal stippling (HP:0010655)	2.56921903
39	Mitochondrial inheritance (HP:0001427)	2.56173716
40	Acute encephalopathy (HP:0006846)	2.53746833
41	Abnormal mitochondria in muscle tissue (HP:0008316)	2.53420065
42	Increased serum lactate (HP:0002151)	2.47949177
43	Female pseudohermaphroditism (HP:0010458)	2.44899198
44	Chorioretinal coloboma (HP:0000567)	2.42873984
45	Palmoplantar hyperkeratosis (HP:0000972)	2.42702795
46	Increased CSF lactate (HP:0002490)	2.37886701
47	Decreased lacrimation (HP:0000633)	2.32885656
48	Hepatocellular necrosis (HP:0001404)	2.31965808
49	Palmar hyperkeratosis (HP:0010765)	2.30491085
50	Polymicrogyria (HP:0002126)	2.26809967
51	Progressive macrocephaly (HP:0004481)	2.26575171
52	Rhabdomyolysis (HP:0003201)	2.24577500
53	Polyneuropathy (HP:0001271)	2.19863879
54	Exercise intolerance (HP:0003546)	2.19087033
55	Abnormality of vision evoked potentials (HP:0000649)	2.18895357
56	CNS demyelination (HP:0007305)	2.15712565
57	Septo-optic dysplasia (HP:0100842)	2.13213785
58	Increased hepatocellular lipid droplets (HP:0006565)	2.09236767
59	Hepatic necrosis (HP:0002605)	2.05000353
60	Respiratory failure (HP:0002878)	2.02066483
61	Posterior embryotoxon (HP:0000627)	2.01945851
62	Broad nasal tip (HP:0000455)	2.01786506
63	Postnatal microcephaly (HP:0005484)	1.98864757
64	True hermaphroditism (HP:0010459)	1.98228094
65	Abnormality of the line of Schwalbe (HP:0008048)	1.97522080
66	Lipid accumulation in hepatocytes (HP:0006561)	1.96231687
67	Spastic tetraplegia (HP:0002510)	1.94446518
68	Widely spaced teeth (HP:0000687)	1.91354249
69	Large hands (HP:0001176)	1.90100530
70	Plantar hyperkeratosis (HP:0007556)	1.89237631
71	Depressed nasal ridge (HP:0000457)	1.88216167
72	Flat face (HP:0012368)	1.87628410
73	Generalized amyotrophy (HP:0003700)	1.87538529
74	Congenital stationary night blindness (HP:0007642)	1.87032898
75	Pancreatic cysts (HP:0001737)	1.85331786
76	Primary adrenal insufficiency (HP:0008207)	1.83107892
77	Molar tooth sign on MRI (HP:0002419)	1.81376762
78	Abnormality of midbrain morphology (HP:0002418)	1.81376762
79	Overfolded helix (HP:0000396)	1.79181494
80	Renal Fanconi syndrome (HP:0001994)	1.78075697
81	Hypoplastic iliac wings (HP:0002866)	1.76689401
82	Abnormal epiphyseal ossification (HP:0010656)	1.76266525
83	Reticulocytopenia (HP:0001896)	1.75842827
84	Abnormality of the labia minora (HP:0012880)	1.75206208
85	Pancreatic fibrosis (HP:0100732)	1.74320921
86	Scrotal hypoplasia (HP:0000046)	1.70257604
87	Congenital, generalized hypertrichosis (HP:0004540)	1.69706360
88	Cerebral edema (HP:0002181)	1.69213634
89	Thickened nuchal skin fold (HP:0000474)	1.67713941
90	External ear malformation (HP:0008572)	1.66613967
91	Aplasia/Hypoplasia of the nipples (HP:0006709)	1.65241898
92	Anxiety (HP:0000739)	1.63027859
93	3-Methylglutaconic aciduria (HP:0003535)	1.62855056
94	Metabolic acidosis (HP:0001942)	1.58637368
95	Aplasia/hypoplasia of the uterus (HP:0008684)	1.56075729
96	Optic disc pallor (HP:0000543)	1.55528951
97	Abnormal respiratory epithelium morphology (HP:0012253)	1.54974590
98	Abnormal respiratory motile cilium morphology (HP:0005938)	1.54974590
99	Medial flaring of the eyebrow (HP:0010747)	1.53798944
100	Absent septum pellucidum (HP:0001331)	1.53495816

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MKNK1	6.78853257
2	TAOK2	4.97655301
3	TAOK1	4.73723871
4	MAP3K11	3.55980627
5	MAP3K3	3.45826283
6	MAP2K3	3.13405562
7	JAK3	2.10004920
8	MKNK2	11.2040257
9	ABL2	1.86899832
10	DYRK1A	1.60723765
11	SRPK1	1.58652602
12	VRK2	1.30997089
13	MAP4K2	1.23197245
14	MAP3K5	1.17221722
15	WNK3	0.87652067
16	GRK1	0.80618296
17	CHEK2	0.79512797
18	ZAK	0.74738981
19	VRK1	0.73382594
20	TIE1	0.70638130
21	TSSK6	0.65621267
22	MAP3K1	0.65246718
23	ADRBK2	0.63726641
24	MAP3K8	0.60609585
25	WNK4	0.60183425
26	EIF2AK3	0.58236865
27	BCKDK	0.56857761
28	PRKCQ	0.53836352
29	TLK1	0.52917076
30	BMPR1B	0.52243515
31	NUAK1	0.51664662
32	NEK1	0.50455768
33	PLK3	0.47000804
34	BUB1	0.46688710
35	DYRK2	0.43578980
36	TRIM28	0.42608311
37	TXK	0.41025823
38	STK16	0.39041522
39	MST4	0.38473229
40	PASK	0.37464825
41	PLK2	0.36857794
42	STK39	0.36380884
43	FRK	0.34322450
44	OXSR1	0.32304522
45	EIF2AK1	0.31245969
46	CSNK1A1	0.29995627
47	TAF1	0.28403707
48	NME1	0.27788396
49	INSRR	0.27423261
50	CASK	0.26835197
51	PINK1	0.23526328
52	PHKG2	0.23022908
53	PHKG1	0.23022908
54	EPHB2	0.22064138
55	CSNK2A2	0.22045911
56	TEC	0.21084773
57	PDK2	0.20704807
58	GRK5	0.20645555
59	PRKCG	0.20483611
60	CDC7	0.20454666
61	CSNK1G1	0.20188555
62	TGFBR1	0.20001884
63	PLK4	0.19773048
64	PAK3	0.17950882
65	PBK	0.17916278
66	WEE1	0.17914213
67	TNIK	0.17676877
68	MAP3K12	0.17505604
69	OBSCN	0.17213244
70	DAPK3	0.16939109
71	CSNK1G3	0.16805744
72	MYLK	0.15708889
73	EIF2AK2	0.15184656
74	CSNK1E	0.15092988
75	IGF1R	0.14550080
76	CSNK2A1	0.13711850
77	PRKCD	0.13453399
78	CSNK1G2	0.12021230
79	PRKCE	0.11214449
80	AURKA	0.10560597
81	PRKCA	0.10500708
82	FLT3	0.10090765
83	ABL1	0.09713374
84	DAPK1	0.08932518
85	CCNB1	0.08867086
86	MAP2K6	0.08077742
87	CDK8	0.07993587
88	ADRBK1	0.07514033
89	PRKACA	0.06888444
90	MAP2K7	0.06795308
91	PLK1	0.06716810
92	MATK	0.05858740
93	MUSK	0.05823207
94	STK4	0.05344421
95	CSNK1A1L	0.04783254
96	PRKCB	0.04288460
97	ATR	0.03517060
98	AURKB	0.03254552
99	KIT	0.03024512
100	PIM2	0.02748113

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	4.84022342
2	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	4.33419875
3	Proteasome_Homo sapiens_hsa03050	4.17890142
4	RNA polymerase_Homo sapiens_hsa03020	3.36117581
5	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.21598465
6	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.84834627
7	Oxidative phosphorylation_Homo sapiens_hsa00190	2.45350862
8	Fatty acid elongation_Homo sapiens_hsa00062	2.40378038
9	One carbon pool by folate_Homo sapiens_hsa00670	2.38820352
10	Ribosome_Homo sapiens_hsa03010	2.30150382
11	Butanoate metabolism_Homo sapiens_hsa00650	2.21754539
12	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	2.20536897
13	Propanoate metabolism_Homo sapiens_hsa00640	2.19637233
14	Parkinsons disease_Homo sapiens_hsa05012	1.99799075
15	Taste transduction_Homo sapiens_hsa04742	1.81892734
16	Huntingtons disease_Homo sapiens_hsa05016	1.63271228
17	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.62777493
18	Tryptophan metabolism_Homo sapiens_hsa00380	1.56901784
19	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.51266784
20	Protein export_Homo sapiens_hsa03060	1.49516637
21	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.46222511
22	beta-Alanine metabolism_Homo sapiens_hsa00410	1.36650739
23	Peroxisome_Homo sapiens_hsa04146	1.27818733
24	Alzheimers disease_Homo sapiens_hsa05010	1.21485614
25	Pyrimidine metabolism_Homo sapiens_hsa00240	1.18713409
26	Lysine degradation_Homo sapiens_hsa00310	1.17269978
27	Fatty acid degradation_Homo sapiens_hsa00071	1.14072315
28	Nucleotide excision repair_Homo sapiens_hsa03420	1.13903784
29	RNA transport_Homo sapiens_hsa03013	1.12761568
30	Homologous recombination_Homo sapiens_hsa03440	1.10729295
31	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.09003457
32	Cardiac muscle contraction_Homo sapiens_hsa04260	1.04315164
33	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.03595840
34	Asthma_Homo sapiens_hsa05310	0.98347269
35	Linoleic acid metabolism_Homo sapiens_hsa00591	0.97912273
36	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.97701164
37	Caffeine metabolism_Homo sapiens_hsa00232	0.96659549
38	Fatty acid metabolism_Homo sapiens_hsa01212	0.95670345
39	Mismatch repair_Homo sapiens_hsa03430	0.94170589
40	Phototransduction_Homo sapiens_hsa04744	0.93955960
41	Glycerolipid metabolism_Homo sapiens_hsa00561	0.92438789
42	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.91478559
43	RNA degradation_Homo sapiens_hsa03018	0.88622652
44	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.88506596
45	Purine metabolism_Homo sapiens_hsa00230	0.88204288
46	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.87928671
47	Primary immunodeficiency_Homo sapiens_hsa05340	0.87922448
48	Steroid biosynthesis_Homo sapiens_hsa00100	0.84856449
49	Allograft rejection_Homo sapiens_hsa05330	0.84592084
50	DNA replication_Homo sapiens_hsa03030	0.83413302
51	Nitrogen metabolism_Homo sapiens_hsa00910	0.81766235
52	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.73254088
53	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.72681439
54	Type I diabetes mellitus_Homo sapiens_hsa04940	0.68845674
55	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.68354815
56	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.68029581
57	Fanconi anemia pathway_Homo sapiens_hsa03460	0.67770021
58	Graft-versus-host disease_Homo sapiens_hsa05332	0.65263581
59	Metabolic pathways_Homo sapiens_hsa01100	0.64765518
60	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.64235607
61	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.61771492
62	Folate biosynthesis_Homo sapiens_hsa00790	0.61089865
63	Carbon metabolism_Homo sapiens_hsa01200	0.60677848
64	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.60085253
65	Basal transcription factors_Homo sapiens_hsa03022	0.59873480
66	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.57928212
67	Nicotine addiction_Homo sapiens_hsa05033	0.57118766
68	Chemical carcinogenesis_Homo sapiens_hsa05204	0.55867539
69	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.55815777
70	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.54938870
71	Non-homologous end-joining_Homo sapiens_hsa03450	0.53525883
72	Pyruvate metabolism_Homo sapiens_hsa00620	0.50764758
73	Retinol metabolism_Homo sapiens_hsa00830	0.50722978
74	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.50565015
75	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.49525831
76	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.47211350
77	Selenocompound metabolism_Homo sapiens_hsa00450	0.45520288
78	Fat digestion and absorption_Homo sapiens_hsa04975	0.45271571
79	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.45233829
80	Viral myocarditis_Homo sapiens_hsa05416	0.44130965
81	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.43866812
82	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.43692387
83	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.43403432
84	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.43390865
85	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.40660926
86	Glutathione metabolism_Homo sapiens_hsa00480	0.40139326
87	Ether lipid metabolism_Homo sapiens_hsa00565	0.39987033
88	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.39284560
89	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.39242275
90	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.38327239
91	Olfactory transduction_Homo sapiens_hsa04740	0.35207441
92	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.34950510
93	Rheumatoid arthritis_Homo sapiens_hsa05323	0.34419802
94	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.30908905
95	Antigen processing and presentation_Homo sapiens_hsa04612	0.30669703
96	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.30663165
97	Base excision repair_Homo sapiens_hsa03410	0.28653168
98	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.28258472
99	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.27928045
100	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.27166689

GAPDHP64

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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