GAPDHP65

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)7.32470212
2cytidine metabolic process (GO:0046087)7.01491316
3cytidine catabolic process (GO:0006216)7.01491316
4cytidine deamination (GO:0009972)7.01491316
5eosinophil chemotaxis (GO:0048245)6.78349270
6protein prenylation (GO:0018342)6.38372728
7prenylation (GO:0097354)6.38372728
8eosinophil migration (GO:0072677)6.11835916
9regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.95310756
10pyrimidine ribonucleoside catabolic process (GO:0046133)5.90035060
11fucose catabolic process (GO:0019317)5.64276385
12L-fucose metabolic process (GO:0042354)5.64276385
13L-fucose catabolic process (GO:0042355)5.64276385
14negative regulation of T cell receptor signaling pathway (GO:0050860)5.32071501
15negative regulation of Ras GTPase activity (GO:0034261)5.07694948
16proteasome assembly (GO:0043248)4.79125950
17positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.69495680
18positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.69495680
19positive regulation of mitotic sister chromatid separation (GO:1901970)4.69495680
20ribosomal small subunit assembly (GO:0000028)4.46774115
21macrophage chemotaxis (GO:0048246)4.35063448
22regulation of mononuclear cell migration (GO:0071675)4.34278807
23negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)4.31362474
24protein deneddylation (GO:0000338)4.00646053
25regulation of T cell receptor signaling pathway (GO:0050856)3.96679864
26chaperone-mediated protein transport (GO:0072321)3.92775447
27DNA demethylation (GO:0080111)3.89897119
28cullin deneddylation (GO:0010388)3.88951178
29protein neddylation (GO:0045116)3.81559065
30positive regulation of growth hormone secretion (GO:0060124)3.81244664
31negative regulation of oligodendrocyte differentiation (GO:0048715)3.73799683
32localization within membrane (GO:0051668)3.73595558
33iron-sulfur cluster assembly (GO:0016226)3.70000431
34metallo-sulfur cluster assembly (GO:0031163)3.70000431
35vesicle fusion (GO:0006906)3.69015333
36ATP synthesis coupled proton transport (GO:0015986)3.68854092
37energy coupled proton transport, down electrochemical gradient (GO:0015985)3.68854092
38regulation of cellular amino acid metabolic process (GO:0006521)3.68551401
39branch elongation of an epithelium (GO:0060602)3.66098733
40DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.62930474
41negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.56499459
42signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.48146571
43intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.48146571
44signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.47327063
45signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.47327063
46signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.47327063
47regulation of timing of cell differentiation (GO:0048505)3.45960618
48mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.40916643
49coenzyme A biosynthetic process (GO:0015937)3.37832494
50regulation of sister chromatid cohesion (GO:0007063)3.35091873
51negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.31459402
52signal transduction involved in DNA integrity checkpoint (GO:0072401)3.29050926
53signal transduction involved in DNA damage checkpoint (GO:0072422)3.29050926
54transcription elongation from RNA polymerase III promoter (GO:0006385)3.27700852
55termination of RNA polymerase III transcription (GO:0006386)3.27700852
56signal transduction involved in cell cycle checkpoint (GO:0072395)3.26858805
57regulation of development, heterochronic (GO:0040034)3.25923272
58positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.25736030
59monocyte chemotaxis (GO:0002548)3.25165302
60spinal cord association neuron differentiation (GO:0021527)3.24169733
61RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.23453211
62tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.23453211
63preassembly of GPI anchor in ER membrane (GO:0016254)3.22859583
64autophagic vacuole fusion (GO:0000046)3.21360695
65forebrain neuron differentiation (GO:0021879)3.14560157
66DNA dealkylation (GO:0035510)3.12721428
67negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.11878367
68negative regulation of ligase activity (GO:0051352)3.11878367
69positive regulation of calcium ion import (GO:0090280)3.10856040
70establishment of protein localization to mitochondrial membrane (GO:0090151)3.10174638
71regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.06364788
72mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.05198137
73detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)3.04876488
74ganglion development (GO:0061548)3.03548855
75membrane budding (GO:0006900)2.95756038
76intracellular protein transmembrane import (GO:0044743)2.93412915
77negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.90852812
78platelet dense granule organization (GO:0060155)2.89005335
79cerebral cortex neuron differentiation (GO:0021895)2.87931458
80olfactory bulb development (GO:0021772)2.86311922
81growth hormone secretion (GO:0030252)2.85863318
82organ growth (GO:0035265)2.85696432
83antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.85224453
84positive regulation of cell cycle arrest (GO:0071158)2.84230145
85regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.80486094
86negative regulation by host of viral transcription (GO:0043922)2.77433199
87acrosome assembly (GO:0001675)2.74741603
88organelle membrane fusion (GO:0090174)2.72803086
89respiratory electron transport chain (GO:0022904)2.72512843
90positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.72462851
91anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.72051402
92electron transport chain (GO:0022900)2.69773613
93GPI anchor biosynthetic process (GO:0006506)2.69619916
94GPI anchor metabolic process (GO:0006505)2.69178856
95pyrimidine nucleoside catabolic process (GO:0046135)2.68284670
96DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.66680657
97protein complex biogenesis (GO:0070271)2.66144326
98oxidative demethylation (GO:0070989)2.66116200
99detection of chemical stimulus involved in sensory perception of taste (GO:0050912)2.63337547
100positive regulation of interleukin-1 beta secretion (GO:0050718)2.62322314

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse6.15222219
2VDR_22108803_ChIP-Seq_LS180_Human4.45093452
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.11273000
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.69751589
5GATA1_22025678_ChIP-Seq_K562_Human3.68158103
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.21016150
7ELF1_17652178_ChIP-ChIP_JURKAT_Human3.15506934
8BP1_19119308_ChIP-ChIP_Hs578T_Human3.13927495
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.90960804
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.67959756
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.57035942
12NOTCH1_21737748_ChIP-Seq_TLL_Human2.56777760
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.40039186
14ZNF274_21170338_ChIP-Seq_K562_Hela2.30911742
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.28099164
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.25022513
17RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.21474830
18FLI1_27457419_Chip-Seq_LIVER_Mouse2.19770332
19YY1_21170310_ChIP-Seq_MESCs_Mouse2.18579035
20SRF_21415370_ChIP-Seq_HL-1_Mouse2.16988303
21VDR_23849224_ChIP-Seq_CD4+_Human2.05063435
22ELK1_19687146_ChIP-ChIP_HELA_Human1.82808837
23SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.77867469
24IGF1R_20145208_ChIP-Seq_DFB_Human1.68313329
25PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.67036693
26CREB1_15753290_ChIP-ChIP_HEK293T_Human1.66231072
27EZH2_22144423_ChIP-Seq_EOC_Human1.66036810
28IRF1_19129219_ChIP-ChIP_H3396_Human1.65153316
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.62578218
30CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.62068324
31PCGF2_27294783_Chip-Seq_ESCs_Mouse1.59567668
32FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.57249254
33FOXP3_21729870_ChIP-Seq_TREG_Human1.47659892
34IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.46656684
35TP53_22573176_ChIP-Seq_HFKS_Human1.45413994
36HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.44806017
37SRY_22984422_ChIP-ChIP_TESTIS_Rat1.41703119
38TAF15_26573619_Chip-Seq_HEK293_Human1.37619025
39ZFP57_27257070_Chip-Seq_ESCs_Mouse1.36024799
40TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31600291
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.29579524
42PCGF2_27294783_Chip-Seq_NPCs_Mouse1.29365479
43GBX2_23144817_ChIP-Seq_PC3_Human1.27876536
44AR_21572438_ChIP-Seq_LNCaP_Human1.25450047
45FUS_26573619_Chip-Seq_HEK293_Human1.24850662
46POU5F1_16153702_ChIP-ChIP_HESCs_Human1.23388004
47IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.22210162
48HTT_18923047_ChIP-ChIP_STHdh_Human1.18373459
49P300_19829295_ChIP-Seq_ESCs_Human1.14815712
50CTBP2_25329375_ChIP-Seq_LNCAP_Human1.13210761
51EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.07911878
52POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.07634332
53POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07546554
54TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07546554
55FOXA1_25329375_ChIP-Seq_VCAP_Human1.06319845
56FOXA1_27270436_Chip-Seq_PROSTATE_Human1.06319845
57BCAT_22108803_ChIP-Seq_LS180_Human1.05270317
58THAP11_20581084_ChIP-Seq_MESCs_Mouse1.04147977
59GABP_19822575_ChIP-Seq_HepG2_Human1.03892009
60NANOG_19829295_ChIP-Seq_ESCs_Human1.02902146
61SOX2_19829295_ChIP-Seq_ESCs_Human1.02902146
62MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.01907552
63CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.01854209
64ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.01672892
65NANOG_20526341_ChIP-Seq_ESCs_Human1.01115031
66NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.99755015
67KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.99590994
68KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.99590994
69KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.99590994
70NCOR_22424771_ChIP-Seq_293T_Human0.98828381
71CBP_20019798_ChIP-Seq_JUKART_Human0.97236618
72IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.97236618
73EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.96619756
74REST_18959480_ChIP-ChIP_MESCs_Mouse0.95778470
75HOXB4_20404135_ChIP-ChIP_EML_Mouse0.95172526
76NFE2_27457419_Chip-Seq_LIVER_Mouse0.94759481
77TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.94414036
78SUZ12_27294783_Chip-Seq_NPCs_Mouse0.94303454
79MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.92313158
80AR_20517297_ChIP-Seq_VCAP_Human0.91585880
81MYC_18940864_ChIP-ChIP_HL60_Human0.89792874
82MYC_18358816_ChIP-ChIP_MESCs_Mouse0.89509156
83FOXH1_21741376_ChIP-Seq_EPCs_Human0.89096931
84EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.88829427
85REST_21632747_ChIP-Seq_MESCs_Mouse0.88584291
86GATA3_26560356_Chip-Seq_TH1_Human0.88079537
87PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.87777608
88GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.86788807
89FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.85683178
90MYC_19829295_ChIP-Seq_ESCs_Human0.85385780
91ERG_20517297_ChIP-Seq_VCAP_Human0.85298722
92GATA3_21878914_ChIP-Seq_MCF-7_Human0.84643938
93RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.84563877
94PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.83048743
95GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.82444327
96CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.82422161
97FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.81082001
98DCP1A_22483619_ChIP-Seq_HELA_Human0.79058203
99KLF5_20875108_ChIP-Seq_MESCs_Mouse0.77868433
100BMI1_23680149_ChIP-Seq_NPCS_Mouse0.77375615

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis6.03477686
2MP0002822_catalepsy4.85539025
3MP0008789_abnormal_olfactory_epithelium3.45176698
4MP0006072_abnormal_retinal_apoptosis3.28421034
5MP0002102_abnormal_ear_morphology3.03181655
6MP0006082_CNS_inflammation2.77521133
7MP0005499_abnormal_olfactory_system2.65651204
8MP0005394_taste/olfaction_phenotype2.65651204
9MP0002751_abnormal_autonomic_nervous2.58999042
10MP0003303_peritoneal_inflammation2.45520823
11MP0005671_abnormal_response_to2.24867265
12MP0001529_abnormal_vocalization2.14177545
13MP0001919_abnormal_reproductive_system2.11123526
14MP0002876_abnormal_thyroid_physiology2.07642807
15MP0000372_irregular_coat_pigmentation2.04595924
16MP0001664_abnormal_digestion1.91450681
17MP0005645_abnormal_hypothalamus_physiol1.86924887
18MP0005253_abnormal_eye_physiology1.83322937
19MP0004145_abnormal_muscle_electrophysio1.81502666
20MP0006276_abnormal_autonomic_nervous1.80487303
21MP0001905_abnormal_dopamine_level1.72551084
22MP0002095_abnormal_skin_pigmentation1.57485879
23MP0002163_abnormal_gland_morphology1.56624091
24MP0005389_reproductive_system_phenotype1.55946628
25MP0005646_abnormal_pituitary_gland1.53138688
26MP0001968_abnormal_touch/_nociception1.50779844
27MP0002638_abnormal_pupillary_reflex1.45477603
28MP0003880_abnormal_central_pattern1.41690470
29MP0009745_abnormal_behavioral_response1.40960138
30MP0001984_abnormal_olfaction1.40321856
31MP0008872_abnormal_physiological_respon1.36632309
32MP0006292_abnormal_olfactory_placode1.35737376
33MP0001986_abnormal_taste_sensitivity1.33511010
34MP0001663_abnormal_digestive_system1.30340428
35MP0002837_dystrophic_cardiac_calcinosis1.28632736
36MP0004270_analgesia1.27459555
37MP0005084_abnormal_gallbladder_morpholo1.23327882
38MP0005551_abnormal_eye_electrophysiolog1.21384018
39MP0000049_abnormal_middle_ear1.19063205
40MP0002234_abnormal_pharynx_morphology1.17459295
41MP0008875_abnormal_xenobiotic_pharmacok1.17424836
42MP0002736_abnormal_nociception_after1.17327698
43MP0004147_increased_porphyrin_level1.16629392
44MP0004142_abnormal_muscle_tone1.16413986
45MP0001188_hyperpigmentation1.15759769
46MP0003786_premature_aging1.15409515
47MP0008877_abnormal_DNA_methylation1.13816181
48MP0005423_abnormal_somatic_nervous1.10862344
49MP0003011_delayed_dark_adaptation1.10067873
50MP0009785_altered_susceptibility_to1.05994504
51MP0003763_abnormal_thymus_physiology1.05538958
52MP0003646_muscle_fatigue1.04467949
53MP0002734_abnormal_mechanical_nocicepti1.01431071
54MP0003937_abnormal_limbs/digits/tail_de0.99975140
55MP0002733_abnormal_thermal_nociception0.99000843
56MP0002735_abnormal_chemical_nociception0.97886466
57MP0004885_abnormal_endolymph0.96315279
58MP0001293_anophthalmia0.93782334
59MP0002277_abnormal_respiratory_mucosa0.93396233
60MP0005379_endocrine/exocrine_gland_phen0.91766723
61MP0002272_abnormal_nervous_system0.89995188
62MP0005377_hearing/vestibular/ear_phenot0.89357922
63MP0003878_abnormal_ear_physiology0.89357922
64MP0000467_abnormal_esophagus_morphology0.89254680
65MP0001970_abnormal_pain_threshold0.87443223
66MP0000631_abnormal_neuroendocrine_gland0.87243688
67MP0002184_abnormal_innervation0.86338669
68MP0005381_digestive/alimentary_phenotyp0.86191659
69MP0005386_behavior/neurological_phenoty0.85222446
70MP0004924_abnormal_behavior0.85222446
71MP0001501_abnormal_sleep_pattern0.84349445
72MP0005083_abnormal_biliary_tract0.83036566
73MP0001485_abnormal_pinna_reflex0.81523891
74MP0002653_abnormal_ependyma_morphology0.79564089
75MP0002752_abnormal_somatic_nervous0.78508199
76MP0002909_abnormal_adrenal_gland0.76718559
77MP0000026_abnormal_inner_ear0.76371280
78MP0008058_abnormal_DNA_repair0.76096209
79MP0009046_muscle_twitch0.75594106
80MP0001502_abnormal_circadian_rhythm0.75312769
81MP0008995_early_reproductive_senescence0.75077622
82MP0002557_abnormal_social/conspecific_i0.73591385
83MP0003787_abnormal_imprinting0.73382615
84MP0002210_abnormal_sex_determination0.72140531
85MP0001963_abnormal_hearing_physiology0.70479161
86MP0002572_abnormal_emotion/affect_behav0.70317762
87MP0009333_abnormal_splenocyte_physiolog0.70252867
88MP0001764_abnormal_homeostasis0.70213638
89MP0005391_vision/eye_phenotype0.69280848
90MP0003866_abnormal_defecation0.68885080
91MP0003195_calcinosis0.68815751
92MP0001873_stomach_inflammation0.68361263
93MP0005167_abnormal_blood-brain_barrier0.66705200
94MP0005166_decreased_susceptibility_to0.65725975
95MP0004742_abnormal_vestibular_system0.63780944
96MP0001486_abnormal_startle_reflex0.63264086
97MP0003635_abnormal_synaptic_transmissio0.63046638
98MP0000778_abnormal_nervous_system0.62605288
99MP0002233_abnormal_nose_morphology0.59546079
100MP0008775_abnormal_heart_ventricle0.58875447

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of long-chain fatty-acid metabolism (HP:0010964)4.76441556
2Acute necrotizing encephalopathy (HP:0006965)4.00018551
3Mitochondrial inheritance (HP:0001427)3.76045416
4Abnormal mitochondria in muscle tissue (HP:0008316)3.60181796
5Abnormality of the renal collecting system (HP:0004742)3.55568439
6Duplicated collecting system (HP:0000081)3.49631891
7Hepatocellular necrosis (HP:0001404)3.45595983
8Adactyly (HP:0009776)3.45537775
9Progressive macrocephaly (HP:0004481)3.36009038
10Acute encephalopathy (HP:0006846)3.29221991
11Large for gestational age (HP:0001520)3.28005302
12Increased CSF lactate (HP:0002490)3.20448079
13Aplastic anemia (HP:0001915)3.14661776
14Hepatic necrosis (HP:0002605)3.10417366
15Severe muscular hypotonia (HP:0006829)3.01355022
16Brushfield spots (HP:0001088)2.90146317
173-Methylglutaconic aciduria (HP:0003535)2.89080008
18Abnormality of fatty-acid metabolism (HP:0004359)2.88684422
19Lactic acidosis (HP:0003128)2.79692142
20Hypoproteinemia (HP:0003075)2.73887237
21Palpebral edema (HP:0100540)2.73756793
22Broad-based gait (HP:0002136)2.60804938
23IgG deficiency (HP:0004315)2.60294613
24Pancreatic cysts (HP:0001737)2.60267264
25Hypoplastic pelvis (HP:0008839)2.60103804
26Autoamputation (HP:0001218)2.59210545
27Increased serum lactate (HP:0002151)2.58989304
28Ureteral stenosis (HP:0000071)2.57802474
29Molar tooth sign on MRI (HP:0002419)2.53386671
30Abnormality of midbrain morphology (HP:0002418)2.53386671
31Increased hepatocellular lipid droplets (HP:0006565)2.48603898
32Long foot (HP:0001833)2.47366195
33True hermaphroditism (HP:0010459)2.47356587
34Pancreatic fibrosis (HP:0100732)2.45147941
35Cerebral edema (HP:0002181)2.45025407
36Dry hair (HP:0011359)2.34561138
37Congenital stationary night blindness (HP:0007642)2.31321375
38Abolished electroretinogram (ERG) (HP:0000550)2.31157756
39Exercise intolerance (HP:0003546)2.30875951
40Ureteral obstruction (HP:0006000)2.30509409
41Acute lymphatic leukemia (HP:0006721)2.30347102
42Optic disc pallor (HP:0000543)2.29103299
43Delayed CNS myelination (HP:0002188)2.25678316
44Renal Fanconi syndrome (HP:0001994)2.24600516
45Lipid accumulation in hepatocytes (HP:0006561)2.22885238
46CNS demyelination (HP:0007305)2.19328063
47Renal cortical cysts (HP:0000803)2.18836854
48Abnormality of the phalanges of the 2nd finger (HP:0009541)2.17455490
49Severe combined immunodeficiency (HP:0004430)2.17183380
50Methylmalonic acidemia (HP:0002912)2.15396118
51Menstrual irregularities (HP:0000858)2.14614690
52Elevated erythrocyte sedimentation rate (HP:0003565)2.13616882
53Respiratory failure (HP:0002878)2.13311890
54Aplasia/hypoplasia of the uterus (HP:0008684)2.12876784
55Increased intramyocellular lipid droplets (HP:0012240)2.12109458
56T lymphocytopenia (HP:0005403)2.10743027
57Thyroiditis (HP:0100646)2.09819137
58Type 2 muscle fiber atrophy (HP:0003554)2.09566028
59Progressive muscle weakness (HP:0003323)2.08463824
60Abnormality of the renal cortex (HP:0011035)2.08298635
61Anhidrosis (HP:0000970)2.07498485
62Methylmalonic aciduria (HP:0012120)2.05662089
63Abnormality of T cell number (HP:0011839)2.05027034
64Decreased muscle mass (HP:0003199)2.02036571
65Reduced subcutaneous adipose tissue (HP:0003758)2.01989947
66Increased IgM level (HP:0003496)1.95277520
67Chorioretinal coloboma (HP:0000567)1.94638457
68Anxiety (HP:0000739)1.93815528
69Medial flaring of the eyebrow (HP:0010747)1.91150594
70Nephronophthisis (HP:0000090)1.90431307
71Emotional lability (HP:0000712)1.87538648
72Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.84183894
73Decreased activity of mitochondrial respiratory chain (HP:0008972)1.84183894
74Decreased electroretinogram (ERG) amplitude (HP:0000654)1.83465683
75Abnormality of the prostate (HP:0008775)1.79348103
76Myoglobinuria (HP:0002913)1.78926807
77Hypomagnesemia (HP:0002917)1.77302330
78Abnormal rod and cone electroretinograms (HP:0008323)1.76626457
79Stenosis of the external auditory canal (HP:0000402)1.76384969
80Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.75188229
81Abnormality of alanine metabolism (HP:0010916)1.75188229
82Hyperalaninemia (HP:0003348)1.75188229
83Hypoplastic nipples (HP:0002557)1.73901249
84Hypoalbuminemia (HP:0003073)1.73681187
85Abnormal albumin level (HP:0012116)1.73681187
86Cerebral hypomyelination (HP:0006808)1.73391771
87Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.73368923
88Lethargy (HP:0001254)1.73157162
89Rhabdomyolysis (HP:0003201)1.72980765
90Abnormality of the labia minora (HP:0012880)1.71900594
91Polydipsia (HP:0001959)1.70964976
92Abnormal drinking behavior (HP:0030082)1.70964976
93Gait imbalance (HP:0002141)1.70935005
94Attenuation of retinal blood vessels (HP:0007843)1.68141603
95Pendular nystagmus (HP:0012043)1.68064177
96Absent rod-and cone-mediated responses on ERG (HP:0007688)1.66714274
97Muscle fiber atrophy (HP:0100295)1.64878068
98Colon cancer (HP:0003003)1.64484237
99Decreased lacrimation (HP:0000633)1.63758548
100Sudden death (HP:0001699)1.63090068

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MKNK27.82298020
2MKNK14.68646620
3TAOK23.02598088
4TAOK12.95128559
5MAP3K112.80402961
6TXK2.56354288
7KDR2.22107820
8TESK22.16253298
9VRK21.99323442
10MAP3K31.93551454
11SRPK11.83922026
12BCKDK1.83152337
13MAP4K21.74123545
14TESK11.64019904
15ABL21.63487757
16TRIM281.58321610
17JAK31.53012052
18ZAK1.51528970
19ADRBK21.49548138
20MAP2K31.47224337
21NUAK11.40690541
22INSRR1.40045057
23DYRK1A1.39616911
24TIE11.36665725
25MST41.35404895
26LIMK11.29437974
27PHKG21.28888738
28PHKG11.28888738
29GRK11.25279459
30FRK1.17515007
31DYRK21.14936952
32TLK11.14431226
33BUB11.14424536
34MAP3K51.13587281
35MAP3K121.13365136
36VRK11.08325892
37BMPR1B1.05222426
38WNK30.98995578
39WNK40.94466245
40CSNK1G20.91131792
41CSNK1G30.86308680
42ITK0.84478439
43BCR0.83500026
44PRKCQ0.79419437
45STK160.76318182
46MARK10.73955887
47MAPK130.73943333
48CSNK1G10.73476861
49PAK60.68610405
50EIF2AK30.66764290
51MAP2K70.65727491
52DAPK10.63833566
53MUSK0.63589704
54OXSR10.62272621
55TAOK30.61857859
56PLK20.61232505
57MAP2K60.60121367
58TSSK60.60092291
59CSNK1A1L0.60090182
60AURKA0.59122263
61CHEK20.58387328
62PINK10.57310634
63OBSCN0.50509657
64PRKCE0.49421994
65CSNK1A10.49160127
66DAPK20.49157807
67FGFR20.48796612
68STK390.48258029
69CASK0.47642240
70TEC0.47056332
71MINK10.46638751
72LMTK20.46315131
73PIK3CA0.44266474
74PLK30.42378502
75GRK50.42344645
76NTRK20.41061409
77FES0.40624472
78TAF10.39876022
79MAPKAPK50.36169171
80NME10.35461749
81MAP3K40.34941049
82SYK0.34654867
83SCYL20.34408447
84PRKCG0.33065200
85CSNK2A10.31486941
86IGF1R0.31004255
87PDK20.29724655
88CAMK2A0.29643685
89MOS0.28816585
90RPS6KA50.27546406
91PRKCA0.27475330
92PRKACA0.26470822
93PRKD30.25823813
94LCK0.25736002
95FLT30.25600261
96MATK0.25432231
97ADRBK10.25253700
98CDK80.25066444
99GRK70.24991585
100CSNK2A20.24655121

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.26062639
2Oxidative phosphorylation_Homo sapiens_hsa001903.33007003
3RNA polymerase_Homo sapiens_hsa030203.15200546
4SNARE interactions in vesicular transport_Homo sapiens_hsa041302.99745914
5Parkinsons disease_Homo sapiens_hsa050122.90687135
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.62254982
7Primary immunodeficiency_Homo sapiens_hsa053402.54040263
8Protein export_Homo sapiens_hsa030602.51713595
9Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.21523480
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.01825654
11Butanoate metabolism_Homo sapiens_hsa006501.96079123
12Huntingtons disease_Homo sapiens_hsa050161.89018126
13Autoimmune thyroid disease_Homo sapiens_hsa053201.86515836
14Alzheimers disease_Homo sapiens_hsa050101.83123448
15Allograft rejection_Homo sapiens_hsa053301.67447807
16Graft-versus-host disease_Homo sapiens_hsa053321.66013761
17Type I diabetes mellitus_Homo sapiens_hsa049401.64339955
18Cardiac muscle contraction_Homo sapiens_hsa042601.61423753
19Ribosome_Homo sapiens_hsa030101.57909599
20Propanoate metabolism_Homo sapiens_hsa006401.56543899
21Phototransduction_Homo sapiens_hsa047441.49496238
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.47512801
23Antigen processing and presentation_Homo sapiens_hsa046121.42521034
24Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.34828568
25Fatty acid elongation_Homo sapiens_hsa000621.32083942
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.29983962
27Peroxisome_Homo sapiens_hsa041461.25971025
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.22647370
29Taste transduction_Homo sapiens_hsa047421.21608635
30Asthma_Homo sapiens_hsa053101.18216805
31RNA degradation_Homo sapiens_hsa030181.13238150
32Caffeine metabolism_Homo sapiens_hsa002321.06440657
33Pyrimidine metabolism_Homo sapiens_hsa002401.06147294
34Tryptophan metabolism_Homo sapiens_hsa003801.05238273
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.04492677
36Rheumatoid arthritis_Homo sapiens_hsa053231.04012330
37Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.03277084
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.02096278
39One carbon pool by folate_Homo sapiens_hsa006701.00123706
40Hematopoietic cell lineage_Homo sapiens_hsa046400.99433873
41Nitrogen metabolism_Homo sapiens_hsa009100.99015734
42Maturity onset diabetes of the young_Homo sapiens_hsa049500.97295135
43Intestinal immune network for IgA production_Homo sapiens_hsa046720.95356072
44Linoleic acid metabolism_Homo sapiens_hsa005910.92947223
45Collecting duct acid secretion_Homo sapiens_hsa049660.88630252
46Purine metabolism_Homo sapiens_hsa002300.85847001
47Regulation of autophagy_Homo sapiens_hsa041400.85609969
48Homologous recombination_Homo sapiens_hsa034400.85516970
49Sulfur metabolism_Homo sapiens_hsa009200.84371965
50Spliceosome_Homo sapiens_hsa030400.82114528
51RNA transport_Homo sapiens_hsa030130.80670884
52Basal transcription factors_Homo sapiens_hsa030220.78683974
53Nicotine addiction_Homo sapiens_hsa050330.78589626
54Nucleotide excision repair_Homo sapiens_hsa034200.75500046
55Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.73960125
56Viral myocarditis_Homo sapiens_hsa054160.68923155
57Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.67859368
58alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.66064038
59Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.65685648
60Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.65337654
61Folate biosynthesis_Homo sapiens_hsa007900.63086363
62Fanconi anemia pathway_Homo sapiens_hsa034600.61948384
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.60978345
64Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.60874115
65GABAergic synapse_Homo sapiens_hsa047270.60710716
66beta-Alanine metabolism_Homo sapiens_hsa004100.60064465
67Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.58476968
68Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58417647
69Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.58228298
70Chemical carcinogenesis_Homo sapiens_hsa052040.57736562
71Salmonella infection_Homo sapiens_hsa051320.57563528
72Metabolic pathways_Homo sapiens_hsa011000.57173341
73Olfactory transduction_Homo sapiens_hsa047400.55501393
74Morphine addiction_Homo sapiens_hsa050320.52926284
752-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.52465902
76Retinol metabolism_Homo sapiens_hsa008300.52277284
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50638300
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50560929
79Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.48679432
80Epstein-Barr virus infection_Homo sapiens_hsa051690.48132470
81Synaptic vesicle cycle_Homo sapiens_hsa047210.47468743
82Mismatch repair_Homo sapiens_hsa034300.46725981
83Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.46077573
84Steroid hormone biosynthesis_Homo sapiens_hsa001400.44830340
85Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.44408294
86Systemic lupus erythematosus_Homo sapiens_hsa053220.44224046
87Primary bile acid biosynthesis_Homo sapiens_hsa001200.43927417
88Carbon metabolism_Homo sapiens_hsa012000.42731389
89Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42612953
90Fatty acid degradation_Homo sapiens_hsa000710.42155579
91Ether lipid metabolism_Homo sapiens_hsa005650.42057512
92Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.40886648
93Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.39435064
94Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.37002902
95Dopaminergic synapse_Homo sapiens_hsa047280.36980729
96Pentose and glucuronate interconversions_Homo sapiens_hsa000400.36785143
97Cysteine and methionine metabolism_Homo sapiens_hsa002700.36355902
98T cell receptor signaling pathway_Homo sapiens_hsa046600.32556839
99Glutathione metabolism_Homo sapiens_hsa004800.32302972
100Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.31325686

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