ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	negative regulation of synaptic transmission, GABAergic (GO:0032229)	4.64037407
2	DNA double-strand break processing (GO:0000729)	4.46929484
3	cullin deneddylation (GO:0010388)	4.23720685
4	behavioral response to nicotine (GO:0035095)	4.05347806
5	protein deneddylation (GO:0000338)	4.02873310
6	DNA deamination (GO:0045006)	4.02799215
7	replication fork processing (GO:0031297)	3.98456231
8	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.81721974
9	respiratory chain complex IV assembly (GO:0008535)	3.80331344
10	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.78313307
11	water-soluble vitamin biosynthetic process (GO:0042364)	3.76519586
12	chaperone-mediated protein transport (GO:0072321)	3.70111457
13	DNA strand renaturation (GO:0000733)	3.62579545
14	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.58850520
15	ATP synthesis coupled proton transport (GO:0015986)	3.58850520
16	peptidyl-histidine modification (GO:0018202)	3.58554574
17	cerebral cortex radially oriented cell migration (GO:0021799)	3.56566055
18	negative regulation of astrocyte differentiation (GO:0048712)	3.49724876
19	response to pheromone (GO:0019236)	3.49547304
20	rRNA modification (GO:0000154)	3.45526043
21	regulation of cilium movement (GO:0003352)	3.37940893
22	C4-dicarboxylate transport (GO:0015740)	3.36448723
23	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.35717052
24	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.35717052
25	regulation of helicase activity (GO:0051095)	3.32930725
26	DNA damage response, detection of DNA damage (GO:0042769)	3.23066345
27	maturation of 5.8S rRNA (GO:0000460)	3.22833506
28	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.19905140
29	negative regulation of JAK-STAT cascade (GO:0046426)	3.14063516
30	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.06132913
31	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.06114004
32	protein-cofactor linkage (GO:0018065)	3.04583558
33	protein neddylation (GO:0045116)	3.04578714
34	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.04106358
35	cytochrome complex assembly (GO:0017004)	3.03728446
36	proteasome assembly (GO:0043248)	3.02701025
37	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	3.02471981
38	pseudouridine synthesis (GO:0001522)	3.00043896
39	recombinational repair (GO:0000725)	2.96983078
40	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.94300621
41	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.94300621
42	NADH dehydrogenase complex assembly (GO:0010257)	2.94300621
43	double-strand break repair via homologous recombination (GO:0000724)	2.93827817
44	DNA catabolic process, exonucleolytic (GO:0000738)	2.90961002
45	protein complex biogenesis (GO:0070271)	2.90021404
46	termination of RNA polymerase III transcription (GO:0006386)	2.83929219
47	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.83929219
48	axoneme assembly (GO:0035082)	2.80849299
49	rRNA methylation (GO:0031167)	2.80464564
50	L-fucose catabolic process (GO:0042355)	2.78042116
51	fucose catabolic process (GO:0019317)	2.78042116
52	L-fucose metabolic process (GO:0042354)	2.78042116
53	gamma-aminobutyric acid transport (GO:0015812)	2.77927982
54	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.73878506
55	platelet dense granule organization (GO:0060155)	2.71195352
56	chromatin remodeling at centromere (GO:0031055)	2.71132677
57	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.71085339
58	negative regulation of protein localization to cell surface (GO:2000009)	2.70628142
59	CENP-A containing nucleosome assembly (GO:0034080)	2.69609601
60	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.66852003
61	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.66852003
62	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.66852003
63	regulation of mitotic spindle checkpoint (GO:1903504)	2.66829696
64	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.66829696
65	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.66783601
66	oxidative demethylation (GO:0070989)	2.66200753
67	regulation of action potential (GO:0098900)	2.65152241
68	DNA demethylation (GO:0080111)	2.63945615
69	cell migration in hindbrain (GO:0021535)	2.63646062
70	tRNA processing (GO:0008033)	2.63451963
71	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.63347865
72	mitochondrial respiratory chain complex assembly (GO:0033108)	2.63061345
73	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class	2.62730893
74	piRNA metabolic process (GO:0034587)	2.62684522
75	indolalkylamine metabolic process (GO:0006586)	2.62046905
76	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.62009672
77	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.62009672
78	mannosylation (GO:0097502)	2.60674976
79	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.58914169
80	negative regulation of DNA recombination (GO:0045910)	2.58468154
81	tachykinin receptor signaling pathway (GO:0007217)	2.55609837
82	regulation of timing of cell differentiation (GO:0048505)	2.55352169
83	protein polyglutamylation (GO:0018095)	2.53937407
84	regulation of collateral sprouting (GO:0048670)	2.53337455
85	intracellular protein transmembrane import (GO:0044743)	2.53096884
86	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.52363068
87	tryptophan metabolic process (GO:0006568)	2.51930078
88	negative regulation of mast cell activation (GO:0033004)	2.51826212
89	signal peptide processing (GO:0006465)	2.51593074
90	retinal cone cell development (GO:0046549)	2.51492578
91	regulation of telomere maintenance (GO:0032204)	2.51344109
92	regulation of cellular amino acid metabolic process (GO:0006521)	2.50776614
93	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.50729587
94	indole-containing compound catabolic process (GO:0042436)	2.50285914
95	indolalkylamine catabolic process (GO:0046218)	2.50285914
96	tryptophan catabolic process (GO:0006569)	2.50285914
97	negative regulation of telomere maintenance (GO:0032205)	2.49098968
98	regulation of meiosis I (GO:0060631)	2.48328893
99	cilium morphogenesis (GO:0060271)	2.47875262
100	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.45467762

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.10593825
2	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.52290793
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.46943791
4	ZNF274_21170338_ChIP-Seq_K562_Hela	3.43421886
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.06361343
6	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.98602331
7	VDR_22108803_ChIP-Seq_LS180_Human	2.89389828
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.69850459
9	IGF1R_20145208_ChIP-Seq_DFB_Human	2.66158304
10	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.60825238
11	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.40720272
12	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.27732420
13	EWS_26573619_Chip-Seq_HEK293_Human	2.24507366
14	FUS_26573619_Chip-Seq_HEK293_Human	2.19406785
15	GBX2_23144817_ChIP-Seq_PC3_Human	2.19375505
16	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.15893359
17	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.15822319
18	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.13027458
19	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.00608538
20	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.99923453
21	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.99873713
22	VDR_23849224_ChIP-Seq_CD4+_Human	1.93945008
23	ELK1_19687146_ChIP-ChIP_HELA_Human	1.93616899
24	P300_19829295_ChIP-Seq_ESCs_Human	1.91322452
25	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.90578921
26	EZH2_22144423_ChIP-Seq_EOC_Human	1.87408800
27	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.86281675
28	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.82231290
29	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.80166090
30	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.78508754
31	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.73591123
32	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.60431760
33	FOXP3_21729870_ChIP-Seq_TREG_Human	1.57498233
34	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.53366187
35	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.50202915
36	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.50061869
37	CBP_20019798_ChIP-Seq_JUKART_Human	1.49096539
38	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.49096539
39	IRF1_19129219_ChIP-ChIP_H3396_Human	1.45099094
40	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.44545360
41	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.41061670
42	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.34677458
43	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.34179059
44	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.32998818
45	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.32073438
46	ER_23166858_ChIP-Seq_MCF-7_Human	1.32018500
47	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.30832145
48	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.29989417
49	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.29906723
50	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.29820134
51	MYC_18940864_ChIP-ChIP_HL60_Human	1.29765052
52	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.28671996
53	TAF15_26573619_Chip-Seq_HEK293_Human	1.26401083
54	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.26288297
55	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.26125941
56	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.24344777
57	TP53_22573176_ChIP-Seq_HFKS_Human	1.23540301
58	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.23472057
59	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.22683540
60	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.20153646
61	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.19988697
62	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.18811470
63	TCF4_22108803_ChIP-Seq_LS180_Human	1.18791533
64	NANOG_19829295_ChIP-Seq_ESCs_Human	1.17650157
65	SOX2_19829295_ChIP-Seq_ESCs_Human	1.17650157
66	AR_25329375_ChIP-Seq_VCAP_Human	1.16740692
67	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.15239982
68	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.15200117
69	TCF4_23295773_ChIP-Seq_U87_Human	1.14953253
70	BCAT_22108803_ChIP-Seq_LS180_Human	1.14528041
71	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.14190579
72	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.13662299
73	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.13662299
74	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.12321809
75	GABP_19822575_ChIP-Seq_HepG2_Human	1.08019390
76	SMAD4_21799915_ChIP-Seq_A2780_Human	1.07776306
77	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.07520662
78	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.07167498
79	NCOR_22424771_ChIP-Seq_293T_Human	1.06215919
80	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.06070368
81	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.06070368
82	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.05465299
83	RUNX2_22187159_ChIP-Seq_PCA_Human	1.03805537
84	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.03513904
85	STAT3_23295773_ChIP-Seq_U87_Human	1.02283774
86	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.00349565
87	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	0.98710086
88	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.98335131
89	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.95011492
90	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.93455853
91	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.93330680
92	REST_21632747_ChIP-Seq_MESCs_Mouse	0.92699258
93	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.90832612
94	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.90475577
95	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.88940950
96	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.88893474
97	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.88468931
98	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.88303585
99	HOXB7_26014856_ChIP-Seq_BT474_Human	0.87562954
100	P53_22387025_ChIP-Seq_ESCs_Mouse	0.87236887

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	4.17541811
2	MP0000372_irregular_coat_pigmentation	3.20483689
3	MP0008877_abnormal_DNA_methylation	2.93487865
4	MP0008789_abnormal_olfactory_epithelium	2.48339051
5	MP0005551_abnormal_eye_electrophysiolog	2.48157581
6	MP0005408_hypopigmentation	2.44682642
7	MP0004147_increased_porphyrin_level	2.36804033
8	MP0001968_abnormal_touch/_nociception	2.31605363
9	MP0008058_abnormal_DNA_repair	2.22409159
10	MP0002736_abnormal_nociception_after	2.17554276
11	MP0003195_calcinosis	2.04341337
12	MP0003693_abnormal_embryo_hatching	2.00747282
13	MP0001293_anophthalmia	1.99275251
14	MP0002102_abnormal_ear_morphology	1.98673842
15	MP0002938_white_spotting	1.95887071
16	MP0002234_abnormal_pharynx_morphology	1.89440691
17	MP0004270_analgesia	1.89230431
18	MP0000427_abnormal_hair_cycle	1.88621355
19	MP0004885_abnormal_endolymph	1.87934972
20	MP0006072_abnormal_retinal_apoptosis	1.84180143
21	MP0003136_yellow_coat_color	1.82066549
22	MP0005075_abnormal_melanosome_morpholog	1.80856504
23	MP0005499_abnormal_olfactory_system	1.78480400
24	MP0005394_taste/olfaction_phenotype	1.78480400
25	MP0010094_abnormal_chromosome_stability	1.76716367
26	MP0001984_abnormal_olfaction	1.71655784
27	MP0003718_maternal_effect	1.69755106
28	MP0009745_abnormal_behavioral_response	1.69502605
29	MP0002837_dystrophic_cardiac_calcinosis	1.64353750
30	MP0000631_abnormal_neuroendocrine_gland	1.63910221
31	MP0001529_abnormal_vocalization	1.63473899
32	MP0002751_abnormal_autonomic_nervous	1.57405178
33	MP0002095_abnormal_skin_pigmentation	1.52304095
34	MP0002272_abnormal_nervous_system	1.48535352
35	MP0005253_abnormal_eye_physiology	1.46991240
36	MP0004145_abnormal_muscle_electrophysio	1.46063273
37	MP0004381_abnormal_hair_follicle	1.45790959
38	MP0003011_delayed_dark_adaptation	1.43284623
39	MP0003880_abnormal_central_pattern	1.41438238
40	MP0008057_abnormal_DNA_replication	1.39072133
41	MP0004742_abnormal_vestibular_system	1.35119781
42	MP0003786_premature_aging	1.33576097
43	MP0002163_abnormal_gland_morphology	1.30007572
44	MP0002822_catalepsy	1.29278056
45	MP0002735_abnormal_chemical_nociception	1.28720335
46	MP0006035_abnormal_mitochondrial_morpho	1.28304156
47	MP0002734_abnormal_mechanical_nocicepti	1.26698159
48	MP0004133_heterotaxia	1.26516563
49	MP0004142_abnormal_muscle_tone	1.25761253
50	MP0000647_abnormal_sebaceous_gland	1.24169994
51	MP0003787_abnormal_imprinting	1.24074666
52	MP0003646_muscle_fatigue	1.23551368
53	MP0001986_abnormal_taste_sensitivity	1.22982635
54	MP0001486_abnormal_startle_reflex	1.20344298
55	MP0008872_abnormal_physiological_respon	1.19349565
56	MP0006276_abnormal_autonomic_nervous	1.19251614
57	MP0001177_atelectasis	1.16869203
58	MP0003186_abnormal_redox_activity	1.16138477
59	MP0002572_abnormal_emotion/affect_behav	1.15053133
60	MP0003121_genomic_imprinting	1.14739240
61	MP0001501_abnormal_sleep_pattern	1.11391922
62	MP0003635_abnormal_synaptic_transmissio	1.11240552
63	MP0002653_abnormal_ependyma_morphology	1.10549367
64	MP0002733_abnormal_thermal_nociception	1.06498403
65	MP0003122_maternal_imprinting	1.03133993
66	MP0001485_abnormal_pinna_reflex	1.01945258
67	MP0005379_endocrine/exocrine_gland_phen	0.99914278
68	MP0008875_abnormal_xenobiotic_pharmacok	0.98502125
69	MP0005451_abnormal_body_composition	0.98171838
70	MP0005195_abnormal_posterior_eye	0.98154769
71	MP0002752_abnormal_somatic_nervous	0.97108900
72	MP0000778_abnormal_nervous_system	0.96737782
73	MP0009046_muscle_twitch	0.96165896
74	MP0001970_abnormal_pain_threshold	0.93141545
75	MP0006036_abnormal_mitochondrial_physio	0.90582528
76	MP0001764_abnormal_homeostasis	0.90285707
77	MP0000569_abnormal_digit_pigmentation	0.89273766
78	MP0005646_abnormal_pituitary_gland	0.88725963
79	MP0002067_abnormal_sensory_capabilities	0.88603927
80	MP0002064_seizures	0.88232648
81	MP0005391_vision/eye_phenotype	0.87871998
82	MP0002638_abnormal_pupillary_reflex	0.86590257
83	MP0002557_abnormal_social/conspecific_i	0.86461299
84	MP0002233_abnormal_nose_morphology	0.81337752
85	MP0005310_abnormal_salivary_gland	0.79059339
86	MP0005377_hearing/vestibular/ear_phenot	0.78398400
87	MP0003878_abnormal_ear_physiology	0.78398400
88	MP0004957_abnormal_blastocyst_morpholog	0.77542513
89	MP0003937_abnormal_limbs/digits/tail_de	0.76851757
90	MP0005174_abnormal_tail_pigmentation	0.75864686
91	MP0002138_abnormal_hepatobiliary_system	0.74509500
92	MP0002063_abnormal_learning/memory/cond	0.74392553
93	MP0005389_reproductive_system_phenotype	0.74310038
94	MP0000026_abnormal_inner_ear	0.74111601
95	MP0002098_abnormal_vibrissa_morphology	0.73920963
96	MP0008995_early_reproductive_senescence	0.73905427
97	MP0000358_abnormal_cell_content/	0.72967402
98	MP0002184_abnormal_innervation	0.72769140
99	MP0000049_abnormal_middle_ear	0.71954464
100	MP0005084_abnormal_gallbladder_morpholo	0.71334043

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	3.94947145
2	True hermaphroditism (HP:0010459)	3.81626461
3	Pancreatic fibrosis (HP:0100732)	3.78078846
4	Congenital stationary night blindness (HP:0007642)	3.73441212
5	Abnormality of the labia minora (HP:0012880)	3.44576673
6	Colon cancer (HP:0003003)	3.40922755
7	Abnormality of midbrain morphology (HP:0002418)	3.32735410
8	Molar tooth sign on MRI (HP:0002419)	3.32735410
9	Adrenal hypoplasia (HP:0000835)	3.10343716
10	Medial flaring of the eyebrow (HP:0010747)	3.08481374
11	Increased CSF lactate (HP:0002490)	3.04579370
12	Chronic hepatic failure (HP:0100626)	2.99562984
13	Acute necrotizing encephalopathy (HP:0006965)	2.95663850
14	Congenital, generalized hypertrichosis (HP:0004540)	2.93520579
15	Mitochondrial inheritance (HP:0001427)	2.93404848
16	Abnormality of the renal medulla (HP:0100957)	2.89610328
17	Nephronophthisis (HP:0000090)	2.85552840
18	Abnormality of the renal cortex (HP:0011035)	2.85321209
19	Methylmalonic acidemia (HP:0002912)	2.85133309
20	Acute encephalopathy (HP:0006846)	2.83269166
21	Gait imbalance (HP:0002141)	2.78222983
22	Pendular nystagmus (HP:0012043)	2.77241623
23	Congenital primary aphakia (HP:0007707)	2.68519974
24	Abnormal biliary tract physiology (HP:0012439)	2.64533881
25	Bile duct proliferation (HP:0001408)	2.64533881
26	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.63650343
27	Hepatocellular necrosis (HP:0001404)	2.60385922
28	Progressive macrocephaly (HP:0004481)	2.56228024
29	Increased hepatocellular lipid droplets (HP:0006565)	2.49943129
30	Cystic liver disease (HP:0006706)	2.49507764
31	Broad-based gait (HP:0002136)	2.49323581
32	Nephrogenic diabetes insipidus (HP:0009806)	2.46882547
33	Increased serum lactate (HP:0002151)	2.44156754
34	Abnormality of alanine metabolism (HP:0010916)	2.44122670
35	Hyperalaninemia (HP:0003348)	2.44122670
36	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.44122670
37	Renal cortical cysts (HP:0000803)	2.43548233
38	Abnormal mitochondria in muscle tissue (HP:0008316)	2.42430308
39	Lipid accumulation in hepatocytes (HP:0006561)	2.37953963
40	Optic disc pallor (HP:0000543)	2.37628753
41	Progressive inability to walk (HP:0002505)	2.34189539
42	Hyperventilation (HP:0002883)	2.30554967
43	Hepatic necrosis (HP:0002605)	2.29593983
44	Thyroid-stimulating hormone excess (HP:0002925)	2.25835005
45	Genital tract atresia (HP:0001827)	2.25604639
46	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.24540413
47	Vaginal atresia (HP:0000148)	2.20337570
48	Gaze-evoked nystagmus (HP:0000640)	2.17906012
49	Methylmalonic aciduria (HP:0012120)	2.13993374
50	Abnormality of the metopic suture (HP:0005556)	2.13873119
51	Anencephaly (HP:0002323)	2.13828223
52	Oligodactyly (hands) (HP:0001180)	2.13735232
53	Postaxial foot polydactyly (HP:0001830)	2.13493972
54	Type II lissencephaly (HP:0007260)	2.12188008
55	Abnormal rod and cone electroretinograms (HP:0008323)	2.11641239
56	Occipital encephalocele (HP:0002085)	2.11055390
57	Inability to walk (HP:0002540)	2.08236062
58	Abnormality of macular pigmentation (HP:0008002)	2.08220070
59	Sclerocornea (HP:0000647)	2.05781715
60	Attenuation of retinal blood vessels (HP:0007843)	2.04634538
61	Preaxial hand polydactyly (HP:0001177)	2.04432924
62	Lissencephaly (HP:0001339)	2.04281941
63	Keratoconus (HP:0000563)	2.03452864
64	Increased corneal curvature (HP:0100692)	2.03452864
65	Astigmatism (HP:0000483)	1.99411650
66	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.99399383
67	Supernumerary spleens (HP:0009799)	1.98253682
68	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.92976857
69	Dandy-Walker malformation (HP:0001305)	1.92234659
70	Male pseudohermaphroditism (HP:0000037)	1.90065597
71	Type 2 muscle fiber atrophy (HP:0003554)	1.88044302
72	Disproportionate short-trunk short stature (HP:0003521)	1.87727506
73	Abnormal lung lobation (HP:0002101)	1.87103757
74	Sloping forehead (HP:0000340)	1.86356089
75	Chorioretinal atrophy (HP:0000533)	1.85761701
76	Oligodactyly (HP:0012165)	1.84904658
77	Narrow forehead (HP:0000341)	1.83255459
78	Abolished electroretinogram (ERG) (HP:0000550)	1.82635984
79	Renal hypoplasia (HP:0000089)	1.82278515
80	Lactic acidosis (HP:0003128)	1.81758452
81	Meckel diverticulum (HP:0002245)	1.81509112
82	Abnormality of the ileum (HP:0001549)	1.80643468
83	Natal tooth (HP:0000695)	1.80166810
84	Hypomagnesemia (HP:0002917)	1.77861707
85	Pachygyria (HP:0001302)	1.77808244
86	Decreased central vision (HP:0007663)	1.77338038
87	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.76935126
88	Abnormality of serum amino acid levels (HP:0003112)	1.76214230
89	Abnormality of methionine metabolism (HP:0010901)	1.74495270
90	Optic nerve coloboma (HP:0000588)	1.74474087
91	Abnormality of glycolysis (HP:0004366)	1.74079911
92	Cerebral edema (HP:0002181)	1.74034653
93	Poor coordination (HP:0002370)	1.73859100
94	Postaxial hand polydactyly (HP:0001162)	1.73812590
95	Increased serum pyruvate (HP:0003542)	1.73628281
96	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.72324293
97	3-Methylglutaconic aciduria (HP:0003535)	1.72250971
98	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.71685203
99	Congenital hepatic fibrosis (HP:0002612)	1.71655529
100	Broad foot (HP:0001769)	1.70143160

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	4.43103733
2	TNIK	3.51140968
3	VRK2	3.17613814
4	TRIM28	3.07105275
5	FRK	2.93599234
6	BUB1	2.44248000
7	GRK1	2.35340025
8	MST4	2.33942500
9	NUAK1	2.26494970
10	EIF2AK1	2.26470471
11	NME1	2.19530068
12	WNK3	2.09402408
13	CASK	2.06113866
14	EIF2AK3	1.86467024
15	TSSK6	1.67535203
16	ADRBK2	1.66828777
17	CSNK1G3	1.62234462
18	PLK3	1.61236823
19	BMPR1B	1.60467095
20	SRPK1	1.57728947
21	ZAK	1.56599800
22	TAF1	1.54645248
23	GRK5	1.53844765
24	CSNK1G1	1.53193022
25	CSNK1A1L	1.51071077
26	DYRK2	1.49172315
27	MARK1	1.46486407
28	MAPK13	1.41023291
29	CSNK1G2	1.34936576
30	PDK2	1.33622147
31	MAP3K4	1.33571226
32	VRK1	1.33137422
33	PLK2	1.26618044
34	MKNK2	1.25934964
35	BCR	1.25895634
36	EPHA4	1.20850233
37	TAOK3	1.19240428
38	PNCK	1.10713514
39	STK16	1.09861957
40	PHKG1	1.08154914
41	PHKG2	1.08154914
42	OXSR1	1.02211614
43	CDC7	1.01474576
44	CCNB1	0.95960760
45	MKNK1	0.94569803
46	WEE1	0.93310420
47	PRKCG	0.92900241
48	PINK1	0.89374371
49	PLK4	0.87198210
50	INSRR	0.84951417
51	STK39	0.84761285
52	DAPK1	0.81717143
53	STK38L	0.80489571
54	TXK	0.77303333
55	EIF2AK2	0.75980061
56	PLK1	0.72053109
57	TLK1	0.71574428
58	CSNK1A1	0.65780116
59	MAP2K7	0.64869216
60	WNK4	0.64189458
61	DAPK2	0.63865137
62	SIK3	0.63273297
63	ADRBK1	0.62774946
64	NEK1	0.62505448
65	PAK3	0.59577641
66	ATR	0.59394850
67	PRKCE	0.59012853
68	PBK	0.57435601
69	MAPKAPK5	0.56204513
70	ACVR1B	0.53736141
71	BCKDK	0.51156400
72	BRSK2	0.50772279
73	NEK2	0.49226762
74	CHEK2	0.47003634
75	TIE1	0.45036639
76	TGFBR1	0.44318635
77	PRKCI	0.43846099
78	EPHB2	0.43421072
79	STK3	0.42742049
80	CDK8	0.40589821
81	ATM	0.38115154
82	CSNK2A1	0.37931351
83	TTK	0.37863827
84	CSNK1E	0.36290978
85	MINK1	0.36094005
86	MAP3K12	0.34803419
87	CDK18	0.33908443
88	ERBB3	0.33048545
89	TNK2	0.32093682
90	PRKACA	0.31268144
91	PRKD3	0.31134733
92	CDK14	0.31063328
93	CSNK1D	0.29862829
94	PRKDC	0.29711934
95	CDK5	0.28675455
96	CHEK1	0.28096166
97	CAMK2A	0.28020874
98	CSNK2A2	0.27802993
99	CDK15	0.27785330
100	AURKB	0.27446251

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.87526923
2	Homologous recombination_Homo sapiens_hsa03440	3.05383977
3	Protein export_Homo sapiens_hsa03060	2.88438053
4	Oxidative phosphorylation_Homo sapiens_hsa00190	2.69017439
5	Non-homologous end-joining_Homo sapiens_hsa03450	2.63776201
6	RNA polymerase_Homo sapiens_hsa03020	2.50496819
7	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.31076977
8	Parkinsons disease_Homo sapiens_hsa05012	2.29651098
9	Mismatch repair_Homo sapiens_hsa03430	2.19341789
10	Fanconi anemia pathway_Homo sapiens_hsa03460	2.15232034
11	Phototransduction_Homo sapiens_hsa04744	2.14609688
12	Basal transcription factors_Homo sapiens_hsa03022	2.03995426
13	RNA degradation_Homo sapiens_hsa03018	2.00171932
14	Nicotine addiction_Homo sapiens_hsa05033	1.96961071
15	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.95875358
16	Propanoate metabolism_Homo sapiens_hsa00640	1.88539585
17	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.75957804
18	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.68349577
19	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.68017333
20	Base excision repair_Homo sapiens_hsa03410	1.62475736
21	Huntingtons disease_Homo sapiens_hsa05016	1.53054468
22	One carbon pool by folate_Homo sapiens_hsa00670	1.45875590
23	RNA transport_Homo sapiens_hsa03013	1.39258122
24	Caffeine metabolism_Homo sapiens_hsa00232	1.35104811
25	Pyrimidine metabolism_Homo sapiens_hsa00240	1.34959023
26	Alzheimers disease_Homo sapiens_hsa05010	1.34689373
27	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.31388107
28	Selenocompound metabolism_Homo sapiens_hsa00450	1.28439675
29	Purine metabolism_Homo sapiens_hsa00230	1.26777742
30	Tryptophan metabolism_Homo sapiens_hsa00380	1.26696307
31	Linoleic acid metabolism_Homo sapiens_hsa00591	1.24060557
32	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.23243283
33	DNA replication_Homo sapiens_hsa03030	1.22511065
34	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.16786454
35	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.16189665
36	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.15259593
37	Nitrogen metabolism_Homo sapiens_hsa00910	1.14141552
38	Nucleotide excision repair_Homo sapiens_hsa03420	1.13451413
39	Sulfur metabolism_Homo sapiens_hsa00920	1.12293184
40	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.11650861
41	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.09750914
42	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.08575139
43	Peroxisome_Homo sapiens_hsa04146	1.08457723
44	Steroid biosynthesis_Homo sapiens_hsa00100	1.07732175
45	Spliceosome_Homo sapiens_hsa03040	1.07465958
46	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.03477377
47	Taste transduction_Homo sapiens_hsa04742	1.02835720
48	Ribosome_Homo sapiens_hsa03010	1.02116444
49	Cardiac muscle contraction_Homo sapiens_hsa04260	0.98560639
50	Butanoate metabolism_Homo sapiens_hsa00650	0.97514536
51	Morphine addiction_Homo sapiens_hsa05032	0.96820762
52	Folate biosynthesis_Homo sapiens_hsa00790	0.95128845
53	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.92842997
54	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.87945149
55	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.83455097
56	Chemical carcinogenesis_Homo sapiens_hsa05204	0.82833026
57	Ether lipid metabolism_Homo sapiens_hsa00565	0.81704193
58	Olfactory transduction_Homo sapiens_hsa04740	0.78684558
59	Pyruvate metabolism_Homo sapiens_hsa00620	0.76241375
60	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.75932641
61	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.75376775
62	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.75270176
63	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.74935947
64	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.74610066
65	Glutamatergic synapse_Homo sapiens_hsa04724	0.74302745
66	Fatty acid elongation_Homo sapiens_hsa00062	0.73307127
67	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.72279528
68	Metabolic pathways_Homo sapiens_hsa01100	0.72068017
69	Glutathione metabolism_Homo sapiens_hsa00480	0.70948481
70	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.68098296
71	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.67647024
72	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.67505957
73	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.67099551
74	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.65073060
75	Collecting duct acid secretion_Homo sapiens_hsa04966	0.64039715
76	beta-Alanine metabolism_Homo sapiens_hsa00410	0.63488634
77	Fatty acid degradation_Homo sapiens_hsa00071	0.62510347
78	GABAergic synapse_Homo sapiens_hsa04727	0.60847465
79	Fatty acid metabolism_Homo sapiens_hsa01212	0.58232583
80	Regulation of autophagy_Homo sapiens_hsa04140	0.58092296
81	Oocyte meiosis_Homo sapiens_hsa04114	0.56853651
82	Retinol metabolism_Homo sapiens_hsa00830	0.51362974
83	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.47293920
84	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.44170529
85	Glycerolipid metabolism_Homo sapiens_hsa00561	0.43860521
86	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.43593361
87	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.42387533
88	Asthma_Homo sapiens_hsa05310	0.41187972
89	Dopaminergic synapse_Homo sapiens_hsa04728	0.41032515
90	mRNA surveillance pathway_Homo sapiens_hsa03015	0.40658105
91	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.40356886
92	Primary immunodeficiency_Homo sapiens_hsa05340	0.38938009
93	Serotonergic synapse_Homo sapiens_hsa04726	0.38654365
94	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.37781663
95	Fat digestion and absorption_Homo sapiens_hsa04975	0.37037614
96	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.36507047
97	Amphetamine addiction_Homo sapiens_hsa05031	0.36282480
98	Circadian entrainment_Homo sapiens_hsa04713	0.36246659
99	Cell cycle_Homo sapiens_hsa04110	0.34601336
100	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.34593024

GAPDHP66

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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