ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	negative regulation of T cell receptor signaling pathway (GO:0050860)	9.78924243
2	eosinophil migration (GO:0072677)	9.38517462
3	regulation of sister chromatid cohesion (GO:0007063)	8.87817084
4	regulation of mononuclear cell migration (GO:0071675)	8.72497310
5	negative regulation of peptidyl-threonine phosphorylation (GO:0010801)	8.46070278
6	L-fucose catabolic process (GO:0042355)	8.12234253
7	fucose catabolic process (GO:0019317)	8.12234253
8	L-fucose metabolic process (GO:0042354)	8.12234253
9	ribosomal small subunit assembly (GO:0000028)	7.88159968
10	branch elongation of an epithelium (GO:0060602)	7.73841856
11	negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)	7.56657274
12	negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)	7.21396828
13	positive regulation of chromosome segregation (GO:0051984)	7.15660806
14	vesicle fusion (GO:0006906)	7.09242381
15	coenzyme A biosynthetic process (GO:0015937)	6.92744140
16	autophagic vacuole fusion (GO:0000046)	6.70362130
17	peptidyl-lysine dimethylation (GO:0018027)	6.62030652
18	macrophage chemotaxis (GO:0048246)	6.29630002
19	organ growth (GO:0035265)	6.17182860
20	protein import into peroxisome matrix (GO:0016558)	6.04587757
21	localization within membrane (GO:0051668)	5.85481781
22	positive regulation of calcium ion import (GO:0090280)	5.67396363
23	axis elongation (GO:0003401)	5.56122443
24	establishment of mitotic spindle orientation (GO:0000132)	5.54379056
25	regulation of T cell receptor signaling pathway (GO:0050856)	5.46298111
26	monocyte chemotaxis (GO:0002548)	5.37149804
27	regulation of nitric-oxide synthase biosynthetic process (GO:0051769)	5.34274516
28	negative regulation of GTPase activity (GO:0034260)	5.26204973
29	negative regulation of GTP catabolic process (GO:0033125)	5.26204973
30	regulation of beta-amyloid formation (GO:1902003)	5.25151774
31	organelle membrane fusion (GO:0090174)	5.22568032
32	non-recombinational repair (GO:0000726)	5.03640621
33	double-strand break repair via nonhomologous end joining (GO:0006303)	5.03640621
34	acrosome assembly (GO:0001675)	4.94511355
35	establishment of mitotic spindle localization (GO:0040001)	4.85818940
36	establishment of spindle orientation (GO:0051294)	4.74603027
37	oxidative demethylation (GO:0070989)	4.66938231
38	detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)	4.47054768
39	organelle fusion (GO:0048284)	4.42700324
40	fucosylation (GO:0036065)	4.37298634
41	ribonucleoside bisphosphate biosynthetic process (GO:0034030)	4.33414078
42	nucleoside bisphosphate biosynthetic process (GO:0033866)	4.33414078
43	purine nucleoside bisphosphate biosynthetic process (GO:0034033)	4.33414078
44	fucose metabolic process (GO:0006004)	4.33053841
45	3-UTR-mediated mRNA stabilization (GO:0070935)	4.28698263
46	positive chemotaxis (GO:0050918)	4.26898008
47	regulation of stem cell maintenance (GO:2000036)	4.26375565
48	histone H3-K9 methylation (GO:0051567)	4.26361783
49	pantothenate metabolic process (GO:0015939)	4.23714911
50	seminiferous tubule development (GO:0072520)	4.23166242
51	negative regulation of circadian rhythm (GO:0042754)	4.15772248
52	regulation of autophagic vacuole assembly (GO:2000785)	4.14219546
53	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	4.10454930
54	coenzyme A metabolic process (GO:0015936)	4.08524682
55	regulation of amyloid precursor protein catabolic process (GO:1902991)	4.07113642
56	detection of chemical stimulus involved in sensory perception of taste (GO:0050912)	3.92240560
57	protein localization to peroxisome (GO:0072662)	3.90186092
58	protein targeting to peroxisome (GO:0006625)	3.90186092
59	establishment of protein localization to peroxisome (GO:0072663)	3.90186092
60	sodium-independent organic anion transport (GO:0043252)	3.85738600
61	regulation of antigen receptor-mediated signaling pathway (GO:0050854)	3.84425886
62	preassembly of GPI anchor in ER membrane (GO:0016254)	3.81841147
63	protein targeting to vacuole (GO:0006623)	3.78421495
64	protein targeting to lysosome (GO:0006622)	3.78421495
65	establishment of protein localization to vacuole (GO:0072666)	3.78421495
66	negative regulation of macroautophagy (GO:0016242)	3.77849700
67	positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)	3.77395832
68	metallo-sulfur cluster assembly (GO:0031163)	3.74090917
69	iron-sulfur cluster assembly (GO:0016226)	3.74090917
70	DNA integration (GO:0015074)	3.72336458
71	peroxisomal transport (GO:0043574)	3.65980209
72	proteasome assembly (GO:0043248)	3.63697016
73	single-organism membrane fusion (GO:0044801)	3.63583729
74	mitochondrial RNA metabolic process (GO:0000959)	3.62327792
75	regulation of fibroblast growth factor receptor signaling pathway (GO:0040036)	3.59284104
76	negative regulation of purine nucleotide catabolic process (GO:0033122)	3.52222655
77	DNA demethylation (GO:0080111)	3.49671875
78	establishment of spindle localization (GO:0051293)	3.49010360
79	folic acid-containing compound biosynthetic process (GO:0009396)	3.45459616
80	regulation of mammary gland epithelial cell proliferation (GO:0033599)	3.42271477
81	negative regulation of nucleotide catabolic process (GO:0030812)	3.40590029
82	telomere maintenance via recombination (GO:0000722)	3.38711766
83	RNA methylation (GO:0001510)	3.38335800
84	negative regulation of nucleoside metabolic process (GO:0045978)	3.37537398
85	ER to Golgi vesicle-mediated transport (GO:0006888)	3.36745590
86	histone H3-K9 modification (GO:0061647)	3.36032413
87	regulation of vacuole organization (GO:0044088)	3.35231611
88	regulation of calcium ion import (GO:0090279)	3.33527564
89	membrane budding (GO:0006900)	3.31114095
90	vesicle targeting (GO:0006903)	3.30063191
91	regulation of cellular amide metabolic process (GO:0034248)	3.25411390
92	regulation of peptidyl-threonine phosphorylation (GO:0010799)	3.15830850
93	imidazole-containing compound metabolic process (GO:0052803)	3.14300862
94	prenylation (GO:0097354)	12.9947411
95	protein prenylation (GO:0018342)	12.9947411
96	negative regulation of Ras GTPase activity (GO:0034261)	11.7295695
97	positive regulation of mitotic sister chromatid separation (GO:1901970)	11.1809613
98	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	11.1809613
99	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	11.1809613
100	eosinophil chemotaxis (GO:0048245)	10.3865944

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GATA1_22025678_ChIP-Seq_K562_Human	9.77790249
2	VDR_22108803_ChIP-Seq_LS180_Human	6.13766256
3	NOTCH1_21737748_ChIP-Seq_TLL_Human	4.66884390
4	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.75973469
5	AR_21572438_ChIP-Seq_LNCaP_Human	2.94569534
6	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.87427201
7	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.70086917
8	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.61739931
9	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.41935553
10	YY1_21170310_ChIP-Seq_MESCs_Mouse	2.37820807
11	SRY_22984422_ChIP-ChIP_TESTIS_Rat	2.35385916
12	ZNF263_19887448_ChIP-Seq_K562_Human	2.19190421
13	ZIC3_20872845_ChIP-ChIP_MESCs_Mouse	2.11659630
14	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	2.05196795
15	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	10.4756866
16	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.99341625
17	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.91434320
18	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.82155722
19	ZNF274_21170338_ChIP-Seq_K562_Hela	1.69296124
20	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.67748068
21	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.59480935
22	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.59190651
23	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.59190651
24	RXR_22108803_ChIP-Seq_LS180_Human	1.58889148
25	BCAT_22108803_ChIP-Seq_LS180_Human	1.58820710
26	TAF15_26573619_Chip-Seq_HEK293_Human	1.52315424
27	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.49117551
28	IRF1_19129219_ChIP-ChIP_H3396_Human	1.45414890
29	GBX2_23144817_ChIP-Seq_PC3_Human	1.41426500
30	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.36517532
31	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.36501807
32	GATA3_26560356_Chip-Seq_TH1_Human	1.35912262
33	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.28698043
34	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.28344789
35	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.24266973
36	TP53_16413492_ChIP-PET_HCT116_Human	1.22719758
37	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.11498646
38	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.10444092
39	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.09988274
40	TP53_22573176_ChIP-Seq_HFKS_Human	1.08284065
41	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.07898633
42	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.04506413
43	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.03879700
44	MYC_18555785_ChIP-Seq_MESCs_Mouse	0.99656879
45	EZH2_22144423_ChIP-Seq_EOC_Human	0.92367423
46	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.89657370
47	WDR5_24793694_ChIP-Seq_LNCAP_Human	0.89363554
48	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.88682131
49	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.88682131
50	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.88236369
51	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	0.84609732
52	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.84291086
53	GATA3_21867929_ChIP-Seq_TH1_Mouse	0.83467766
54	NANOG_20526341_ChIP-Seq_ESCs_Human	0.83194751
55	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.82080052
56	GATA2_21666600_ChIP-Seq_HMVEC_Human	0.80336498
57	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.79326796
58	ERG_20517297_ChIP-Seq_VCAP_Human	0.78730759
59	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	0.78605558
60	VDR_23849224_ChIP-Seq_CD4+_Human	0.78184401
61	STAT1_20625510_ChIP-Seq_HELA_Human	0.76457981
62	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	0.76310507
63	SOX3_22085726_ChIP-Seq_MUSCLE_Mouse	0.76008436
64	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	0.74834456
65	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	0.74834456
66	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	0.74834456
67	CTCF_21964334_Chip-Seq_Bcells_Human	0.74475263
68	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.73476286
69	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.73451807
70	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.72763415
71	TCF4_22108803_ChIP-Seq_LS180_Human	0.70662623
72	NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human	0.70366698
73	LUZP1_20508642_ChIP-Seq_ESCs_Mouse	0.68631534
74	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.68626699
75	P300_19829295_ChIP-Seq_ESCs_Human	0.68623276
76	FUS_26573619_Chip-Seq_HEK293_Human	0.66790321
77	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.66094956
78	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	0.65925053
79	GABP_19822575_ChIP-Seq_HepG2_Human	0.65436642
80	SOX2_19829295_ChIP-Seq_ESCs_Human	0.64743781
81	NANOG_19829295_ChIP-Seq_ESCs_Human	0.64743781
82	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.62735871
83	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.62620241
84	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	0.62032135
85	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.61874391
86	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.61566635
87	OCT4_20526341_ChIP-Seq_ESCs_Human	0.61285855
88	NCOR_22424771_ChIP-Seq_293T_Human	0.61016695
89	TBX3_20139965_ChIP-Seq_MESCs_Mouse	0.60302349
90	RUNX_20019798_ChIP-Seq_JUKART_Human	0.60238931
91	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.59865057
92	CBP_20019798_ChIP-Seq_JUKART_Human	0.59865057
93	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	0.59747722
94	TBX3_20139965_ChIP-Seq_ESCs_Mouse	0.58892125
95	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.58876524
96	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.58438825
97	OCT1_27270436_Chip-Seq_PROSTATE_Human	0.57544721
98	P53_21459846_ChIP-Seq_SAOS-2_Human	0.57273843
99	GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse	0.57179424
100	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.55850756

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003303_peritoneal_inflammation	8.85429600
2	MP0006082_CNS_inflammation	5.09629630
3	MP0001664_abnormal_digestion	3.04257936
4	MP0001663_abnormal_digestive_system	3.03380412
5	MP0000467_abnormal_esophagus_morphology	3.01215362
6	MP0001919_abnormal_reproductive_system	2.76024907
7	MP0002751_abnormal_autonomic_nervous	2.75062935
8	MP0000383_abnormal_hair_follicle	2.36668650
9	MP0005381_digestive/alimentary_phenotyp	2.33866922
10	MP0003115_abnormal_respiratory_system	2.25894687
11	MP0002876_abnormal_thyroid_physiology	2.13749829
12	MP0000566_synostosis	12.7441626
13	MP0000534_abnormal_ureter_morphology	1.93385555
14	MP0005389_reproductive_system_phenotype	1.87141954
15	MP0003937_abnormal_limbs/digits/tail_de	1.57972650
16	MP0003283_abnormal_digestive_organ	1.57177264
17	MP0005166_decreased_susceptibility_to	1.57111091
18	MP0010678_abnormal_skin_adnexa	1.47546366
19	MP0002736_abnormal_nociception_after	1.45076522
20	MP0001915_intracranial_hemorrhage	1.29648057
21	MP0000428_abnormal_craniofacial_morphol	1.16392992
22	MP0001764_abnormal_homeostasis	1.15805752
23	MP0001968_abnormal_touch/_nociception	1.11044938
24	MP0001293_anophthalmia	1.09024205
25	MP0001286_abnormal_eye_development	1.04028397
26	MP0003942_abnormal_urinary_system	1.02590778
27	MP0000490_abnormal_crypts_of	1.00652482
28	MP0001545_abnormal_hematopoietic_system	0.99972946
29	MP0005397_hematopoietic_system_phenotyp	0.99972946
30	MP0003453_abnormal_keratinocyte_physiol	0.99343313
31	MP0001963_abnormal_hearing_physiology	0.99241722
32	MP0000026_abnormal_inner_ear	0.96538553
33	MP0005501_abnormal_skin_physiology	0.95589508
34	MP0005360_urolithiasis	0.93685391
35	MP0003763_abnormal_thymus_physiology	0.92259507
36	MP0002735_abnormal_chemical_nociception	0.81580780
37	MP0000470_abnormal_stomach_morphology	0.80076500
38	MP0003646_muscle_fatigue	0.79472903
39	MP0002109_abnormal_limb_morphology	0.77058374
40	MP0002019_abnormal_tumor_incidence	0.76851770
41	MP0004147_increased_porphyrin_level	0.76838380
42	MP0008872_abnormal_physiological_respon	0.76617775
43	MP0000858_altered_metastatic_potential	0.73937341
44	MP0003329_amyloid_beta_deposits	0.72448031
45	MP0000358_abnormal_cell_content/	0.72386623
46	MP0008058_abnormal_DNA_repair	0.71505192
47	MP0010155_abnormal_intestine_physiology	0.71204087
48	MP0005076_abnormal_cell_differentiation	0.71178630
49	MP0002184_abnormal_innervation	0.71136433
50	MP0003195_calcinosis	0.69591918
51	MP0005253_abnormal_eye_physiology	0.68839538
52	MP0002837_dystrophic_cardiac_calcinosis	0.67673844
53	MP0002210_abnormal_sex_determination	0.66187955
54	MP0002115_abnormal_skeleton_extremities	0.66105820
55	MP0004885_abnormal_endolymph	0.65043623
56	MP0005645_abnormal_hypothalamus_physiol	0.60921735
57	MP0009763_increased_sensitivity_to	0.60388119
58	MP0005332_abnormal_amino_acid	0.59985803
59	MP0000477_abnormal_intestine_morphology	0.59937696
60	MP0004742_abnormal_vestibular_system	0.56673726
61	MP0003638_abnormal_response/metabolism_	0.55380179
62	MP0001986_abnormal_taste_sensitivity	0.53336701
63	MP0005508_abnormal_skeleton_morphology	0.51764393
64	MP0003252_abnormal_bile_duct	0.51490988
65	MP0008875_abnormal_xenobiotic_pharmacok	0.51109324
66	MP0002938_white_spotting	0.50859932
67	MP0005646_abnormal_pituitary_gland	0.49947049
68	MP0009046_muscle_twitch	0.48877222
69	MP0008995_early_reproductive_senescence	0.48868368
70	MP0000538_abnormal_urinary_bladder	0.48457252
71	MP0000432_abnormal_head_morphology	0.48180524
72	MP0005197_abnormal_uvea_morphology	0.47486055
73	MP0003936_abnormal_reproductive_system	0.46649741
74	MP0002752_abnormal_somatic_nervous	0.45603735
75	MP0005085_abnormal_gallbladder_physiolo	0.45482258
76	MP0002136_abnormal_kidney_physiology	0.44640924
77	MP0002272_abnormal_nervous_system	0.44341118
78	MP0005377_hearing/vestibular/ear_phenot	0.42665858
79	MP0003878_abnormal_ear_physiology	0.42665858
80	MP0000681_abnormal_thyroid_gland	0.40275633
81	MP0009672_abnormal_birth_weight	0.38471634
82	MP0002160_abnormal_reproductive_system	0.38429266
83	MP0002405_respiratory_system_inflammati	0.37660715
84	MP0000372_irregular_coat_pigmentation	0.37633129
85	MP0000604_amyloidosis	0.36374941
86	MP0005551_abnormal_eye_electrophysiolog	0.35964487
87	MP0002113_abnormal_skeleton_development	0.35375212
88	MP0001175_abnormal_lung_morphology	0.35090921
89	MP0000049_abnormal_middle_ear	0.34687983
90	MP0005391_vision/eye_phenotype	0.33960878
91	MP0002557_abnormal_social/conspecific_i	0.32916366
92	MP0005025_abnormal_response_to	0.31731721
93	MP0004019_abnormal_vitamin_homeostasis	0.30982602
94	MP0003890_abnormal_embryonic-extraembry	0.30824049
95	MP0002139_abnormal_hepatobiliary_system	0.30383401
96	MP0002102_abnormal_ear_morphology	0.29819068
97	MP0001970_abnormal_pain_threshold	0.29553436
98	MP0009745_abnormal_behavioral_response	0.29248349
99	MP0009643_abnormal_urine_homeostasis	0.29047185
100	MP0000163_abnormal_cartilage_morphology	0.28702633

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Duplicated collecting system (HP:0000081)	8.72865977
2	Long foot (HP:0001833)	8.16868362
3	Abnormality of the renal collecting system (HP:0004742)	7.88380139
4	Large for gestational age (HP:0001520)	7.00963782
5	Abnormality of fatty-acid metabolism (HP:0004359)	6.21573518
6	Adactyly (HP:0009776)	6.07880036
7	Acute lymphatic leukemia (HP:0006721)	6.07838375
8	Hypoplastic pelvis (HP:0008839)	5.85748959
9	Progressive muscle weakness (HP:0003323)	5.56591420
10	Dry hair (HP:0011359)	5.48693604
11	Autoamputation (HP:0001218)	5.09649524
12	Brushfield spots (HP:0001088)	4.93278916
13	Ureteral duplication (HP:0000073)	4.89532900
14	Ureteral stenosis (HP:0000071)	4.87958966
15	Pulmonary artery stenosis (HP:0004415)	4.78015269
16	Reduced subcutaneous adipose tissue (HP:0003758)	4.62837740
17	Steatorrhea (HP:0002570)	4.62618091
18	Ureteral obstruction (HP:0006000)	4.50954846
19	Hypoplastic nipples (HP:0002557)	4.39678572
20	Menstrual irregularities (HP:0000858)	4.38640316
21	Severe muscular hypotonia (HP:0006829)	4.17519205
22	Abnormal ventriculo-arterial connection (HP:0011563)	3.76105545
23	Transposition of the great arteries (HP:0001669)	3.76105545
24	Abnormal connection of the cardiac segments (HP:0011545)	3.76105545
25	Abnormal auditory evoked potentials (HP:0006958)	3.68768477
26	Broad-based gait (HP:0002136)	3.62845722
27	Sudden death (HP:0001699)	3.59422123
28	Fat malabsorption (HP:0002630)	3.59051330
29	Increased number of teeth (HP:0011069)	3.52894004
30	Anhidrosis (HP:0000970)	3.36957532
31	Polyneuropathy (HP:0001271)	3.19945443
32	Palmoplantar hyperkeratosis (HP:0000972)	3.15999447
33	Polymicrogyria (HP:0002126)	3.07171061
34	Wide intermamillary distance (HP:0006610)	3.06294198
35	Abnormality of vision evoked potentials (HP:0000649)	3.02216839
36	Decreased muscle mass (HP:0003199)	2.99986866
37	Palmar hyperkeratosis (HP:0010765)	2.98116818
38	Decreased lacrimation (HP:0000633)	2.97655351
39	Epiphyseal stippling (HP:0010655)	2.82643677
40	Rhabdomyolysis (HP:0003201)	2.76182146
41	Flat face (HP:0012368)	2.75545514
42	Myoglobinuria (HP:0002913)	2.72429724
43	Clubbing of toes (HP:0100760)	2.71021791
44	Broad nasal tip (HP:0000455)	2.59143932
45	Chorioretinal coloboma (HP:0000567)	2.58994985
46	Plantar hyperkeratosis (HP:0007556)	2.50327289
47	Anxiety (HP:0000739)	2.45943629
48	Female pseudohermaphroditism (HP:0010458)	2.44979291
49	Generalized amyotrophy (HP:0003700)	2.42959109
50	Large hands (HP:0001176)	2.38338496
51	Lactic acidosis (HP:0003128)	2.25464542
52	Posterior embryotoxon (HP:0000627)	2.24437972
53	Hypoplastic iliac wings (HP:0002866)	2.21754219
54	Abnormality of the line of Schwalbe (HP:0008048)	2.21127655
55	Purpura (HP:0000979)	2.10034734
56	Overfolded helix (HP:0000396)	2.09409795
57	Widely spaced teeth (HP:0000687)	2.08874794
58	Basal ganglia calcification (HP:0002135)	2.02297715
59	Spastic tetraplegia (HP:0002510)	2.00948225
60	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	11.8205487
61	Abnormal epiphyseal ossification (HP:0010656)	1.99133108
62	Steppage gait (HP:0003376)	1.97045567
63	Aplasia/Hypoplasia of the nipples (HP:0006709)	1.93936817
64	Arterial thrombosis (HP:0004420)	1.91305379
65	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.87787507
66	Gangrene (HP:0100758)	1.85827139
67	External ear malformation (HP:0008572)	1.82636153
68	Prenatal maternal abnormality (HP:0002686)	1.79873057
69	Arthrogryposis multiplex congenita (HP:0002804)	1.78532725
70	Congenital onset (HP:0003577)	1.76637164
71	Thickened calvaria (HP:0002684)	1.76458829
72	Abnormally folded helix (HP:0008544)	1.75944838
73	Primary adrenal insufficiency (HP:0008207)	1.75593997
74	Metabolic acidosis (HP:0001942)	1.75422645
75	Birth length less than 3rd percentile (HP:0003561)	1.74183613
76	Pulmonary embolism (HP:0002204)	1.74175681
77	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.74078923
78	Abnormality of alanine metabolism (HP:0010916)	1.74078923
79	Hyperalaninemia (HP:0003348)	1.74078923
80	Foot dorsiflexor weakness (HP:0009027)	1.72682278
81	Congenital sensorineural hearing impairment (HP:0008527)	1.69026270
82	Absent toe (HP:0010760)	1.67523605
83	Generalized muscle weakness (HP:0003324)	1.65570377
84	Dysdiadochokinesis (HP:0002075)	1.63520743
85	Pendular nystagmus (HP:0012043)	1.62718035
86	Abnormality of the foot musculature (HP:0001436)	1.60869739
87	Scrotal hypoplasia (HP:0000046)	1.59442205
88	Thickened nuchal skin fold (HP:0000474)	1.59177023
89	Depressed nasal ridge (HP:0000457)	1.52044889
90	Hyperammonemia (HP:0001987)	1.46377151
91	Retinopathy (HP:0000488)	1.46106608
92	Stereotypic behavior (HP:0000733)	1.46102147
93	Short philtrum (HP:0000322)	1.45257461
94	Hammertoe (HP:0001765)	1.43930741
95	Brachycephaly (HP:0000248)	1.42770832
96	Abnormal respiratory motile cilium physiology (HP:0012261)	1.41846187
97	Congenital stationary night blindness (HP:0007642)	1.41675378
98	Increased serum lactate (HP:0002151)	1.41007950
99	Postnatal growth retardation (HP:0008897)	1.36247381
100	Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)	1.35328436

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MKNK1	6.77597845
2	TAOK2	5.33270816
3	TAOK1	5.29851756
4	MAP2K3	4.07636511
5	MAP3K3	4.02862449
6	MAP3K11	3.97674980
7	JAK3	2.49127192
8	MKNK2	11.4208798
9	ABL2	1.93100455
10	DYRK1A	1.71279537
11	MAP3K5	1.37996751
12	SRPK1	1.14691318
13	MAP3K1	0.86519498
14	CHEK2	0.79272524
15	WNK4	0.56913275
16	MAP3K8	0.54966604
17	PRKCQ	0.54244929
18	ADRBK2	0.43175488
19	GRK1	0.38609432
20	VRK2	0.34360375
21	WNK3	0.32732310
22	TIE1	0.32684737
23	CSNK1A1	0.28657765
24	TXK	0.23617919
25	INSRR	0.22378570
26	MAP2K6	0.21815073
27	FRK	0.21102024
28	TLK1	0.18049671
29	PINK1	0.18034073
30	GRK7	0.16778723
31	OBSCN	0.16402201
32	IGF1R	0.15856581
33	PRKCD	0.15742001
34	ACVR1B	0.15654190
35	ABL1	0.14596085
36	GRK5	0.14481310
37	VRK1	0.13922161
38	MAP4K2	0.13881198
39	ZAK	0.11502150
40	ADRBK1	0.10201969
41	TSSK6	0.10164706
42	CSNK2A2	0.09936066
43	DYRK2	0.09460275
44	PRKCA	0.08372656
45	PHKG1	0.07795842
46	PHKG2	0.07795842
47	AURKA	0.07750688
48	CSNK2A1	0.07406515
49	MUSK	0.06851540
50	TNIK	0.06634818
51	CSNK1E	0.06164719
52	MAPK13	0.06045850
53	MAP4K1	0.05767485
54	PRKCG	0.04422627
55	KDR	0.04190462
56	BMPR1B	0.04150479
57	EIF2AK3	0.03197937
58	NEK1	0.03180749
59	PRKACA	0.03144169
60	TGFBR1	0.02284838
61	CAMK2D	0.01567159
62	PRKCE	0.01349346
63	PRKCB	0.00598085
64	TAOK3	0.00394157
65	PIM2	0.00339211
66	CAMK2A	0.00329460
67	FGR	-0.0637126
68	SYK	-0.0631103
69	CSNK1G3	-0.0616022
70	CCNB1	-0.0563113
71	MARK1	-0.0554440
72	CSNK1G1	-0.0510072
73	DAPK3	-0.0501388
74	MAPK15	-0.0497410
75	EPHA4	-0.0492066
76	STK16	-0.0477602
77	KIT	-0.0473043
78	ERBB4	-0.0472764
79	DDR2	-0.0443843
80	TAF1	-0.0435972
81	WNK1	-0.0427841
82	SRC	-0.0417422
83	PLK2	-0.0391688
84	MATK	-0.0357598
85	BCKDK	-0.0354783
86	TGFBR2	-0.0333927
87	CAMK2B	-0.0313081
88	PIK3CG	-0.0276103
89	PLK3	-0.0267386
90	PLK4	-0.0255503
91	MYLK	-0.0196213
92	CAMK2G	-0.0181070
93	NTRK2	-0.0155147
94	ITK	-0.0138449
95	NUAK1	-0.0120485
96	EIF2AK1	-0.0074076
97	DAPK2	-0.0051177
98	STK39	-0.0027460
99	OXSR1	-0.0005545
100	TEC	-0.0003777

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	7.18472630
2	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	5.75543847
3	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.46212078
4	RNA polymerase_Homo sapiens_hsa03020	3.15851949
5	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	3.15333483
6	Taste transduction_Homo sapiens_hsa04742	3.13285967
7	Proteasome_Homo sapiens_hsa03050	2.90677660
8	Butanoate metabolism_Homo sapiens_hsa00650	2.80107083
9	One carbon pool by folate_Homo sapiens_hsa00670	2.55366484
10	Fatty acid elongation_Homo sapiens_hsa00062	2.45509246
11	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	2.39562770
12	Propanoate metabolism_Homo sapiens_hsa00640	2.08450528
13	Tryptophan metabolism_Homo sapiens_hsa00380	1.96814028
14	beta-Alanine metabolism_Homo sapiens_hsa00410	1.87897867
15	Lysine degradation_Homo sapiens_hsa00310	1.83773673
16	Glycerolipid metabolism_Homo sapiens_hsa00561	1.63622675
17	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.40853983
18	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.34220174
19	Peroxisome_Homo sapiens_hsa04146	1.19576998
20	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.17707981
21	Nicotine addiction_Homo sapiens_hsa05033	1.07167602
22	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.02773843
23	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.01155571
24	Caffeine metabolism_Homo sapiens_hsa00232	0.96367814
25	Fatty acid degradation_Homo sapiens_hsa00071	0.96035028
26	Amoebiasis_Homo sapiens_hsa05146	0.94931430
27	Linoleic acid metabolism_Homo sapiens_hsa00591	0.91840825
28	Fatty acid metabolism_Homo sapiens_hsa01212	0.90314421
29	Sulfur metabolism_Homo sapiens_hsa00920	0.89667705
30	Asthma_Homo sapiens_hsa05310	0.87687935
31	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.82222368
32	Pyrimidine metabolism_Homo sapiens_hsa00240	0.81848421
33	Retinol metabolism_Homo sapiens_hsa00830	0.80944275
34	Viral myocarditis_Homo sapiens_hsa05416	0.79512254
35	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.76514760
36	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.75283721
37	Fat digestion and absorption_Homo sapiens_hsa04975	0.74199567
38	Phototransduction_Homo sapiens_hsa04744	0.73791907
39	Oxidative phosphorylation_Homo sapiens_hsa00190	0.69632677
40	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.68318561
41	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.67400865
42	Nucleotide excision repair_Homo sapiens_hsa03420	0.66892520
43	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.64908075
44	Allograft rejection_Homo sapiens_hsa05330	0.62631665
45	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.61184732
46	Huntingtons disease_Homo sapiens_hsa05016	0.61178676
47	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.60295837
48	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.56941895
49	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.56471051
50	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.54976120
51	Purine metabolism_Homo sapiens_hsa00230	0.54622233
52	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.54413566
53	Nitrogen metabolism_Homo sapiens_hsa00910	0.52700122
54	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.51339454
55	Complement and coagulation cascades_Homo sapiens_hsa04610	0.50702063
56	Olfactory transduction_Homo sapiens_hsa04740	0.50069572
57	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.48937108
58	Primary immunodeficiency_Homo sapiens_hsa05340	0.48765500
59	Type I diabetes mellitus_Homo sapiens_hsa04940	0.48703869
60	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.46975954
61	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.46153201
62	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.45919924
63	Chemical carcinogenesis_Homo sapiens_hsa05204	0.45707535
64	Graft-versus-host disease_Homo sapiens_hsa05332	0.44875971
65	Parkinsons disease_Homo sapiens_hsa05012	0.43860077
66	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.43364628
67	Metabolic pathways_Homo sapiens_hsa01100	0.43201942
68	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.43191120
69	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.42863208
70	RNA transport_Homo sapiens_hsa03013	0.41333543
71	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.41150655
72	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.40009599
73	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.39050907
74	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.38079730
75	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.36933119
76	Cholinergic synapse_Homo sapiens_hsa04725	0.35412336
77	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.34977871
78	Collecting duct acid secretion_Homo sapiens_hsa04966	0.33985790
79	ABC transporters_Homo sapiens_hsa02010	0.32765560
80	Cardiac muscle contraction_Homo sapiens_hsa04260	0.31190661
81	Calcium signaling pathway_Homo sapiens_hsa04020	0.29789605
82	Ether lipid metabolism_Homo sapiens_hsa00565	0.28598767
83	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.27251830
84	GABAergic synapse_Homo sapiens_hsa04727	0.26853423
85	Sulfur relay system_Homo sapiens_hsa04122	0.25980950
86	Homologous recombination_Homo sapiens_hsa03440	0.25938505
87	Morphine addiction_Homo sapiens_hsa05032	0.24844042
88	Antigen processing and presentation_Homo sapiens_hsa04612	0.24284187
89	Rheumatoid arthritis_Homo sapiens_hsa05323	0.24241391
90	Arginine biosynthesis_Homo sapiens_hsa00220	0.24238552
91	Glutamatergic synapse_Homo sapiens_hsa04724	0.24197787
92	Ribosome_Homo sapiens_hsa03010	0.23322642
93	AMPK signaling pathway_Homo sapiens_hsa04152	0.22053994
94	Serotonergic synapse_Homo sapiens_hsa04726	0.20337688
95	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.18001450
96	Selenocompound metabolism_Homo sapiens_hsa00450	0.17743796
97	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.16987923
98	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.16857710
99	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.16689994
100	Alzheimers disease_Homo sapiens_hsa05010	0.16526493

GAPDHP67

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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