GAPDHP68

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)8.03875424
2regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450916.44850522
3cytidine deamination (GO:0009972)6.02188888
4cytidine metabolic process (GO:0046087)6.02188888
5cytidine catabolic process (GO:0006216)6.02188888
6ATP synthesis coupled proton transport (GO:0015986)5.67802819
7energy coupled proton transport, down electrochemical gradient (GO:0015985)5.67802819
8protein neddylation (GO:0045116)5.42798016
9mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.25397157
10pyrimidine ribonucleoside catabolic process (GO:0046133)5.23512605
11establishment of protein localization to mitochondrial membrane (GO:0090151)5.00808403
12mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.79466067
13respiratory electron transport chain (GO:0022904)4.49267341
14electron transport chain (GO:0022900)4.46967536
15chaperone-mediated protein transport (GO:0072321)4.31855607
16GTP biosynthetic process (GO:0006183)4.12122751
17ribosomal small subunit assembly (GO:0000028)4.11073197
18RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.90977458
19tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.90977458
20protein complex biogenesis (GO:0070271)3.88615748
21regulation of cellular amino acid metabolic process (GO:0006521)3.76190961
22proteasome assembly (GO:0043248)3.74385210
23maturation of SSU-rRNA (GO:0030490)3.68223217
24iron-sulfur cluster assembly (GO:0016226)3.60222236
25metallo-sulfur cluster assembly (GO:0031163)3.60222236
26behavioral response to nicotine (GO:0035095)3.60083829
27nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.56913767
28mitochondrial respiratory chain complex assembly (GO:0033108)3.56809929
29purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.55273484
30sequestering of actin monomers (GO:0042989)3.55211001
31purine nucleoside triphosphate biosynthetic process (GO:0009145)3.55169054
32UTP biosynthetic process (GO:0006228)3.54492770
33DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.52728585
34negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.51342233
35protein deneddylation (GO:0000338)3.50822732
36mitochondrial respiratory chain complex I assembly (GO:0032981)3.50526782
37NADH dehydrogenase complex assembly (GO:0010257)3.50526782
38mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.50526782
39cullin deneddylation (GO:0010388)3.47634961
40hydrogen ion transmembrane transport (GO:1902600)3.44785026
41exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.41553686
42signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.40786124
43signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.40786124
44signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.40786124
45intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.38973349
46signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.38973349
47ATP biosynthetic process (GO:0006754)3.37321084
48rRNA modification (GO:0000154)3.36546529
49UTP metabolic process (GO:0046051)3.34970064
50mannosylation (GO:0097502)3.33606032
51transcription elongation from RNA polymerase III promoter (GO:0006385)3.31992284
52termination of RNA polymerase III transcription (GO:0006386)3.31992284
53signal transduction involved in DNA integrity checkpoint (GO:0072401)3.30479881
54signal transduction involved in DNA damage checkpoint (GO:0072422)3.30479881
55signal transduction involved in cell cycle checkpoint (GO:0072395)3.27932546
56water-soluble vitamin biosynthetic process (GO:0042364)3.25095209
57ubiquinone biosynthetic process (GO:0006744)3.23105517
58platelet dense granule organization (GO:0060155)3.20482239
59ribosomal small subunit biogenesis (GO:0042274)3.20034585
60SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.19751789
61negative regulation of telomere maintenance (GO:0032205)3.18600033
62positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.18564550
63viral transcription (GO:0019083)3.17136821
64proton transport (GO:0015992)3.16902010
65negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.16742048
66negative regulation of ligase activity (GO:0051352)3.16742048
67translation (GO:0006412)3.15837477
68cotranslational protein targeting to membrane (GO:0006613)3.14312570
69ribonucleoside triphosphate biosynthetic process (GO:0009201)3.13402142
70translational termination (GO:0006415)3.13060408
71protein targeting to ER (GO:0045047)3.11132878
72hydrogen transport (GO:0006818)3.08720668
73ubiquinone metabolic process (GO:0006743)3.05633162
74oxidative phosphorylation (GO:0006119)3.02444629
75translational elongation (GO:0006414)3.01241371
76pyrimidine ribonucleoside metabolic process (GO:0046131)3.00960596
77regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.00661762
78protein localization to endoplasmic reticulum (GO:0070972)2.99647441
79ribonucleoprotein complex disassembly (GO:0032988)2.99251147
80CTP biosynthetic process (GO:0006241)2.98199162
81CTP metabolic process (GO:0046036)2.98199162
82establishment of protein localization to endoplasmic reticulum (GO:0072599)2.95341842
83DNA damage response, detection of DNA damage (GO:0042769)2.91588185
84intracellular protein transmembrane import (GO:0044743)2.90068292
85pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.89807948
86respiratory chain complex IV assembly (GO:0008535)2.89479155
87guanosine-containing compound biosynthetic process (GO:1901070)2.87449353
88pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.87021890
89protein targeting to mitochondrion (GO:0006626)2.86859866
90protein peptidyl-prolyl isomerization (GO:0000413)2.82259807
91antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.81593032
92nucleoside triphosphate biosynthetic process (GO:0009142)2.80393186
93L-fucose catabolic process (GO:0042355)2.80196912
94fucose catabolic process (GO:0019317)2.80196912
95L-fucose metabolic process (GO:0042354)2.80196912
96regulation of chronic inflammatory response (GO:0002676)2.78846941
97inner mitochondrial membrane organization (GO:0007007)2.77488735
98establishment of protein localization to mitochondrion (GO:0072655)2.76293797
99L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.75318161
100cellular component biogenesis (GO:0044085)2.74512809

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.80234732
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.67504797
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.77906300
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.67645650
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.62445013
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.40893331
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.40144011
8ELF1_17652178_ChIP-ChIP_JURKAT_Human3.26458922
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.26235259
10ETS1_20019798_ChIP-Seq_JURKAT_Human3.14327755
11VDR_23849224_ChIP-Seq_CD4+_Human2.67210620
12EZH2_22144423_ChIP-Seq_EOC_Human2.59589376
13VDR_22108803_ChIP-Seq_LS180_Human2.54059776
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.53645668
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.45388196
16ELK1_19687146_ChIP-ChIP_HELA_Human2.29262920
17PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.26848331
18SRF_21415370_ChIP-Seq_HL-1_Mouse2.26435842
19ZNF274_21170338_ChIP-Seq_K562_Hela2.22992068
20FOXP3_21729870_ChIP-Seq_TREG_Human2.04663399
21TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.04562797
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.99684738
23MYC_18358816_ChIP-ChIP_MESCs_Mouse1.95899088
24FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.95726135
25YY1_21170310_ChIP-Seq_MESCs_Mouse1.95557202
26CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.94297516
27MYC_18555785_ChIP-Seq_MESCs_Mouse1.83296433
28MYC_18940864_ChIP-ChIP_HL60_Human1.74750511
29GABP_19822575_ChIP-Seq_HepG2_Human1.72105062
30DCP1A_22483619_ChIP-Seq_HELA_Human1.67741799
31THAP11_20581084_ChIP-Seq_MESCs_Mouse1.64694533
32HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.58461577
33IRF1_19129219_ChIP-ChIP_H3396_Human1.57877440
34NOTCH1_21737748_ChIP-Seq_TLL_Human1.53032071
35ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.47893905
36TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46949760
37TP53_22573176_ChIP-Seq_HFKS_Human1.45968616
38EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.45373823
39PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43298406
40IGF1R_20145208_ChIP-Seq_DFB_Human1.43032040
41XRN2_22483619_ChIP-Seq_HELA_Human1.41598974
42TTF2_22483619_ChIP-Seq_HELA_Human1.40754762
43CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.40652920
44FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.34530118
45FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.34103855
46FLI1_27457419_Chip-Seq_LIVER_Mouse1.32932254
47ELK1_22589737_ChIP-Seq_MCF10A_Human1.32796153
48E2F1_18555785_ChIP-Seq_MESCs_Mouse1.30466248
49MYC_19030024_ChIP-ChIP_MESCs_Mouse1.30139376
50PCGF2_27294783_Chip-Seq_ESCs_Mouse1.29650989
51MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.29521692
52HOXB4_20404135_ChIP-ChIP_EML_Mouse1.28572522
53EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.28365730
54BP1_19119308_ChIP-ChIP_Hs578T_Human1.27821548
55IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.23696149
56PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.22667382
57CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.22336889
58EWS_26573619_Chip-Seq_HEK293_Human1.18502023
59AR_20517297_ChIP-Seq_VCAP_Human1.17619984
60E2F4_17652178_ChIP-ChIP_JURKAT_Human1.17397668
61POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.16748382
62PCGF2_27294783_Chip-Seq_NPCs_Mouse1.15292552
63RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.12948553
64NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.12016416
65MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.11560342
66NANOG_20526341_ChIP-Seq_ESCs_Human1.10679824
67IRF8_22096565_ChIP-ChIP_GC-B_Human1.10202563
68EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.09904331
69FOXA1_27270436_Chip-Seq_PROSTATE_Human1.08971006
70FOXA1_25329375_ChIP-Seq_VCAP_Human1.08971006
71PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.04148534
72ERA_21632823_ChIP-Seq_H3396_Human1.04101649
73MYC_19829295_ChIP-Seq_ESCs_Human1.03739961
74TAF2_19829295_ChIP-Seq_ESCs_Human1.02896587
75NANOG_19829295_ChIP-Seq_ESCs_Human1.01477489
76SOX2_19829295_ChIP-Seq_ESCs_Human1.01477489
77NCOR_22424771_ChIP-Seq_293T_Human1.00948883
78AUTS2_25519132_ChIP-Seq_293T-REX_Human0.99538884
79EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.99266417
80ETV2_25802403_ChIP-Seq_MESCs_Mouse0.99070113
81GATA3_21878914_ChIP-Seq_MCF-7_Human0.97270913
82SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.96491749
83SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.94758932
84FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94100906
85YY1_22570637_ChIP-Seq_MALME-3M_Human0.93243254
86PADI4_21655091_ChIP-ChIP_MCF-7_Human0.92480564
87TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.90394860
88SRY_22984422_ChIP-ChIP_TESTIS_Rat0.90372114
89P300_19829295_ChIP-Seq_ESCs_Human0.89762980
90CTBP1_25329375_ChIP-Seq_LNCAP_Human0.89703384
91FUS_26573619_Chip-Seq_HEK293_Human0.87463296
92IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.86926114
93POU5F1_16153702_ChIP-ChIP_HESCs_Human0.86504270
94BMI1_23680149_ChIP-Seq_NPCS_Mouse0.86247026
95CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.86229403
96P53_21459846_ChIP-Seq_SAOS-2_Human0.86049498
97PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.85374938
98MYC_19079543_ChIP-ChIP_MESCs_Mouse0.84842473
99CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.84397524
100ERG_20517297_ChIP-Seq_VCAP_Human0.83944494

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002163_abnormal_gland_morphology3.64787202
2MP0002653_abnormal_ependyma_morphology2.96168333
3MP0006292_abnormal_olfactory_placode2.81520276
4MP0005671_abnormal_response_to2.79836734
5MP0009379_abnormal_foot_pigmentation2.59068037
6MP0005379_endocrine/exocrine_gland_phen2.48353982
7MP0002102_abnormal_ear_morphology2.43149504
8MP0006276_abnormal_autonomic_nervous2.33696334
9MP0001529_abnormal_vocalization2.31356769
10MP0006072_abnormal_retinal_apoptosis2.28477027
11MP0008789_abnormal_olfactory_epithelium2.18067497
12MP0004147_increased_porphyrin_level2.16238891
13MP0005084_abnormal_gallbladder_morpholo2.16077485
14MP0001485_abnormal_pinna_reflex2.00225937
15MP0003880_abnormal_central_pattern1.97423115
16MP0000372_irregular_coat_pigmentation1.95048853
17MP0003786_premature_aging1.85117638
18MP0001905_abnormal_dopamine_level1.81513217
19MP0005645_abnormal_hypothalamus_physiol1.77516734
20MP0004142_abnormal_muscle_tone1.73717991
21MP0002837_dystrophic_cardiac_calcinosis1.73100087
22MP0008872_abnormal_physiological_respon1.72542310
23MP0006036_abnormal_mitochondrial_physio1.71643470
24MP0002138_abnormal_hepatobiliary_system1.71052843
25MP0003878_abnormal_ear_physiology1.70440756
26MP0005377_hearing/vestibular/ear_phenot1.70440756
27MP0003646_muscle_fatigue1.68587329
28MP0001968_abnormal_touch/_nociception1.63963480
29MP0002638_abnormal_pupillary_reflex1.60880088
30MP0008877_abnormal_DNA_methylation1.60000707
31MP0002234_abnormal_pharynx_morphology1.57769101
32MP0005394_taste/olfaction_phenotype1.57651752
33MP0005499_abnormal_olfactory_system1.57651752
34MP0008875_abnormal_xenobiotic_pharmacok1.55642169
35MP0002736_abnormal_nociception_after1.47100363
36MP0001873_stomach_inflammation1.43770806
37MP0005253_abnormal_eye_physiology1.35580171
38MP0001293_anophthalmia1.35366325
39MP0001986_abnormal_taste_sensitivity1.34878170
40MP0005551_abnormal_eye_electrophysiolog1.31508972
41MP0004145_abnormal_muscle_electrophysio1.27524535
42MP0002272_abnormal_nervous_system1.27226732
43MP0002277_abnormal_respiratory_mucosa1.25874867
44MP0005167_abnormal_blood-brain_barrier1.24301034
45MP0005389_reproductive_system_phenotype1.21857498
46MP0001984_abnormal_olfaction1.21439199
47MP0009745_abnormal_behavioral_response1.21056627
48MP0009333_abnormal_splenocyte_physiolog1.20745713
49MP0002160_abnormal_reproductive_system1.19576016
50MP0008058_abnormal_DNA_repair1.18604460
51MP0003787_abnormal_imprinting1.16493321
52MP0003806_abnormal_nucleotide_metabolis1.16230111
53MP0009785_altered_susceptibility_to1.13773558
54MP0006035_abnormal_mitochondrial_morpho1.13305774
55MP0000613_abnormal_salivary_gland1.12317290
56MP0004885_abnormal_endolymph1.10291008
57MP0003763_abnormal_thymus_physiology1.08588143
58MP0003186_abnormal_redox_activity1.06874430
59MP0001919_abnormal_reproductive_system1.04767341
60MP0005075_abnormal_melanosome_morpholog1.02922693
61MP0003137_abnormal_impulse_conducting1.02639538
62MP0003195_calcinosis1.00982461
63MP0002095_abnormal_skin_pigmentation1.00382010
64MP0003866_abnormal_defecation0.99643716
65MP0004742_abnormal_vestibular_system0.99194808
66MP0002876_abnormal_thyroid_physiology0.97421944
67MP0000049_abnormal_middle_ear0.94890687
68MP0009046_muscle_twitch0.94762675
69MP0001835_abnormal_antigen_presentation0.93748735
70MP0003011_delayed_dark_adaptation0.91134859
71MP0003693_abnormal_embryo_hatching0.90818844
72MP0005083_abnormal_biliary_tract0.89938623
73MP0002938_white_spotting0.86443927
74MP0000685_abnormal_immune_system0.84039524
75MP0010386_abnormal_urinary_bladder0.83752258
76MP0003122_maternal_imprinting0.81585083
77MP0002006_tumorigenesis0.79611418
78MP0001727_abnormal_embryo_implantation0.79570281
79MP0002067_abnormal_sensory_capabilities0.79256468
80MP0002735_abnormal_chemical_nociception0.78855493
81MP0002752_abnormal_somatic_nervous0.78772719
82MP0000026_abnormal_inner_ear0.77882206
83MP0001963_abnormal_hearing_physiology0.76449409
84MP0003567_abnormal_fetal_cardiomyocyte0.76359489
85MP0000631_abnormal_neuroendocrine_gland0.76159650
86MP0002572_abnormal_emotion/affect_behav0.75936156
87MP0001764_abnormal_homeostasis0.75808755
88MP0001970_abnormal_pain_threshold0.75488770
89MP0008995_early_reproductive_senescence0.73493419
90MP0005195_abnormal_posterior_eye0.72650328
91MP0005636_abnormal_mineral_homeostasis0.71838189
92MP0001790_abnormal_immune_system0.70717437
93MP0005387_immune_system_phenotype0.70717437
94MP0005646_abnormal_pituitary_gland0.69959539
95MP0002210_abnormal_sex_determination0.69480532
96MP0003718_maternal_effect0.69030862
97MP0002166_altered_tumor_susceptibility0.68942787
98MP0002733_abnormal_thermal_nociception0.67887395
99MP0004133_heterotaxia0.67734973
100MP0001486_abnormal_startle_reflex0.67711421

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.00154031
2Mitochondrial inheritance (HP:0001427)4.71805081
3Abnormal mitochondria in muscle tissue (HP:0008316)4.66949500
4Acute encephalopathy (HP:0006846)4.44358831
5Hepatocellular necrosis (HP:0001404)4.26932368
6Increased CSF lactate (HP:0002490)4.17531224
7Abnormality of midbrain morphology (HP:0002418)4.05922556
8Molar tooth sign on MRI (HP:0002419)4.05922556
9Progressive macrocephaly (HP:0004481)4.01301798
103-Methylglutaconic aciduria (HP:0003535)4.00462141
11Hepatic necrosis (HP:0002605)3.96136300
12Increased hepatocellular lipid droplets (HP:0006565)3.77436422
13Pancreatic cysts (HP:0001737)3.52023094
14Lipid accumulation in hepatocytes (HP:0006561)3.41989863
15Increased intramyocellular lipid droplets (HP:0012240)3.41075295
16Pancreatic fibrosis (HP:0100732)3.31679607
17Renal Fanconi syndrome (HP:0001994)3.31124737
18Increased serum lactate (HP:0002151)3.26547346
19Cerebral edema (HP:0002181)3.26191727
20Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.11979681
21Aplastic anemia (HP:0001915)2.92453859
22Absent rod-and cone-mediated responses on ERG (HP:0007688)2.87645677
23Lactic acidosis (HP:0003128)2.82067831
24True hermaphroditism (HP:0010459)2.77893828
25Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.77491722
26Increased muscle lipid content (HP:0009058)2.75286501
27Optic disc pallor (HP:0000543)2.71054193
28Decreased activity of mitochondrial respiratory chain (HP:0008972)2.69388952
29Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.69388952
30Elevated erythrocyte sedimentation rate (HP:0003565)2.51881281
31Respiratory failure (HP:0002878)2.51864244
32Exercise intolerance (HP:0003546)2.49957502
33Medial flaring of the eyebrow (HP:0010747)2.42722726
34Exertional dyspnea (HP:0002875)2.40936597
35Emotional lability (HP:0000712)2.37320171
36Increased IgM level (HP:0003496)2.36207242
37Sclerocornea (HP:0000647)2.35300640
38Methylmalonic aciduria (HP:0012120)2.34604336
39Aplasia/hypoplasia of the uterus (HP:0008684)2.34316341
40Reticulocytopenia (HP:0001896)2.25762951
41Abnormal rod and cone electroretinograms (HP:0008323)2.23929380
42Abnormality of the labia minora (HP:0012880)2.23861585
43Methylmalonic acidemia (HP:0002912)2.23688185
44Nephronophthisis (HP:0000090)2.20982680
45Lethargy (HP:0001254)2.20947551
46Abnormality of the renal cortex (HP:0011035)2.18174767
47Abnormality of cells of the erythroid lineage (HP:0012130)2.17249639
48Pendular nystagmus (HP:0012043)2.16946780
49Abnormality of dicarboxylic acid metabolism (HP:0010995)2.16910037
50Dicarboxylic aciduria (HP:0003215)2.16910037
51Hyperglycinemia (HP:0002154)2.15515288
52Congenital stationary night blindness (HP:0007642)2.13946963
53CNS demyelination (HP:0007305)2.12342649
54Abnormal biliary tract physiology (HP:0012439)2.11953607
55Bile duct proliferation (HP:0001408)2.11953607
56Delayed CNS myelination (HP:0002188)2.11778933
57IgG deficiency (HP:0004315)2.11550314
58Hypomagnesemia (HP:0002917)2.11417866
59Abolished electroretinogram (ERG) (HP:0000550)2.08345269
60Cerebral hypomyelination (HP:0006808)2.07755230
61Leukodystrophy (HP:0002415)2.02488895
62Decreased electroretinogram (ERG) amplitude (HP:0000654)2.02417081
63Abnormal number of erythroid precursors (HP:0012131)2.02116205
64Pancytopenia (HP:0001876)1.99600830
65Abnormality of magnesium homeostasis (HP:0004921)1.98787261
66Tongue fasciculations (HP:0001308)1.98254913
67Absent thumb (HP:0009777)1.98230504
68Abnormality of the renal medulla (HP:0100957)1.97848538
69Type 2 muscle fiber atrophy (HP:0003554)1.96933497
70Congenital, generalized hypertrichosis (HP:0004540)1.95486490
71Abnormality of renal resorption (HP:0011038)1.93166611
72Cystic liver disease (HP:0006706)1.92434091
73Oral leukoplakia (HP:0002745)1.90964229
74Abnormality of urine glucose concentration (HP:0011016)1.90546174
75Glycosuria (HP:0003076)1.90546174
76Hypoplasia of the uterus (HP:0000013)1.89437055
77Renal cortical cysts (HP:0000803)1.88649018
78Severe combined immunodeficiency (HP:0004430)1.88638697
79Respiratory difficulties (HP:0002880)1.86850370
80Nephrogenic diabetes insipidus (HP:0009806)1.85073349
81Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.84175388
82Abnormality of alanine metabolism (HP:0010916)1.84175388
83Hyperalaninemia (HP:0003348)1.84175388
84Muscle fiber atrophy (HP:0100295)1.83199838
85Microvesicular hepatic steatosis (HP:0001414)1.83117932
86Aplasia/Hypoplasia of the spleen (HP:0010451)1.82152404
87Tubular atrophy (HP:0000092)1.80556897
88Hypoproteinemia (HP:0003075)1.80158739
89Congenital primary aphakia (HP:0007707)1.79773945
90Preaxial hand polydactyly (HP:0001177)1.79140341
91Postaxial foot polydactyly (HP:0001830)1.78950196
92Gait imbalance (HP:0002141)1.78781251
93Anencephaly (HP:0002323)1.77142872
94Macrocytic anemia (HP:0001972)1.77084087
95Optic nerve coloboma (HP:0000588)1.76969612
96X-linked dominant inheritance (HP:0001423)1.75106140
97Progressive microcephaly (HP:0000253)1.74007063
98Microretrognathia (HP:0000308)1.73369731
99Asplenia (HP:0001746)1.72945370
100Retinal dysplasia (HP:0007973)1.71139686

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.55450282
2TXK3.34892651
3MAP4K23.10674446
4BCKDK3.09331991
5ZAK2.99582770
6TLK12.98060599
7KDR2.71090041
8TESK22.28821960
9TIE12.23384439
10STK162.21730004
11GRK12.16136446
12BUB12.05946619
13ADRBK22.03153072
14WNK41.94789088
15VRK11.89388807
16NUAK11.88354260
17WNK31.82184247
18NEK11.71245785
19LIMK11.70972621
20MAP3K121.59315846
21BMPR1B1.57934637
22TRIM281.54892997
23SRPK11.52045946
24TSSK61.39134126
25PINK11.38549713
26MST41.37373927
27FRK1.34221154
28TESK11.22214099
29DYRK21.17131186
30MAP2K71.11297365
31INSRR1.09916808
32MYLK1.05927482
33TAOK31.05053793
34CSNK1G31.04956516
35NME10.98836534
36STK390.96474447
37BLK0.94324339
38MAP4K10.93184065
39DAPK10.91513046
40NME20.90240133
41CSNK1G20.85463138
42CDK190.84780533
43OXSR10.84044429
44TAF10.83119349
45MUSK0.82406022
46EIF2AK10.80327742
47ITK0.79140834
48EPHA40.78639808
49CSNK1G10.78219214
50PIM20.77346640
51DAPK30.73359671
52PDK20.72208457
53CSNK1A1L0.72030543
54CAMKK20.71313600
55BCR0.70927773
56RPS6KA50.70787859
57SCYL20.68219962
58PLK30.67440359
59EIF2AK30.66855388
60AURKA0.66110934
61TEC0.64560296
62CDK80.64305638
63PAK30.62525702
64MAP2K60.60617137
65GRK50.59656655
66MAPKAPK30.59528927
67TNIK0.58213956
68SYK0.57286573
69PRKCQ0.56701423
70RPS6KA40.52623532
71PHKG20.51862013
72PHKG10.51862013
73KIT0.51363849
74OBSCN0.51190520
75PRKCG0.49608607
76AURKB0.46610692
77TGFBR10.46239897
78CSNK2A10.42932816
79PIK3CA0.42327150
80CSNK2A20.42255947
81CDC70.41926195
82ABL20.41676234
83FES0.41346460
84CAMK2A0.39678660
85GRK70.39116320
86IKBKB0.38820146
87PRKACA0.38450476
88ADRBK10.37770564
89PLK10.37664000
90MINK10.37402088
91MAP3K40.36888870
92EIF2AK20.35809530
93CAMK10.35243561
94LCK0.35018090
95CSNK1A10.34939433
96ATR0.34764614
97PLK20.33506234
98PRKCE0.32737217
99MAPK130.32632676
100FLT30.32523906

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.61416821
2Oxidative phosphorylation_Homo sapiens_hsa001904.43596746
3Parkinsons disease_Homo sapiens_hsa050123.90158849
4Ribosome_Homo sapiens_hsa030103.61516157
5Protein export_Homo sapiens_hsa030602.62462129
6Huntingtons disease_Homo sapiens_hsa050162.62400614
7Alzheimers disease_Homo sapiens_hsa050102.61713214
8RNA polymerase_Homo sapiens_hsa030202.58095231
9Cardiac muscle contraction_Homo sapiens_hsa042602.22086627
10Primary immunodeficiency_Homo sapiens_hsa053402.18027940
11Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.13564940
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.86650900
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.83414258
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.80806773
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.68605665
16Sulfur metabolism_Homo sapiens_hsa009201.61028906
17Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.45182313
18Propanoate metabolism_Homo sapiens_hsa006401.42734827
19Sulfur relay system_Homo sapiens_hsa041221.39605936
20Pyrimidine metabolism_Homo sapiens_hsa002401.38923860
21One carbon pool by folate_Homo sapiens_hsa006701.36818027
22alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.35591732
23RNA degradation_Homo sapiens_hsa030181.35313909
24DNA replication_Homo sapiens_hsa030301.33813889
25Homologous recombination_Homo sapiens_hsa034401.33190056
26Mismatch repair_Homo sapiens_hsa034301.32255903
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.31367118
28Fatty acid elongation_Homo sapiens_hsa000621.25016920
29Spliceosome_Homo sapiens_hsa030401.24889847
30Autoimmune thyroid disease_Homo sapiens_hsa053201.22328014
31Peroxisome_Homo sapiens_hsa041461.14227030
32Antigen processing and presentation_Homo sapiens_hsa046121.13176719
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.12965928
34Linoleic acid metabolism_Homo sapiens_hsa005911.11288690
35Allograft rejection_Homo sapiens_hsa053301.10732132
36Fanconi anemia pathway_Homo sapiens_hsa034601.10321882
37Basal transcription factors_Homo sapiens_hsa030221.09834669
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.05911288
39Nucleotide excision repair_Homo sapiens_hsa034201.02283352
402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.02049009
41Graft-versus-host disease_Homo sapiens_hsa053321.01597552
42Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.98344120
43Type I diabetes mellitus_Homo sapiens_hsa049400.93927983
44Steroid biosynthesis_Homo sapiens_hsa001000.93606874
45Purine metabolism_Homo sapiens_hsa002300.91509885
46Cysteine and methionine metabolism_Homo sapiens_hsa002700.91156478
47Intestinal immune network for IgA production_Homo sapiens_hsa046720.88086578
48Butanoate metabolism_Homo sapiens_hsa006500.87859952
49Asthma_Homo sapiens_hsa053100.85531198
50Base excision repair_Homo sapiens_hsa034100.83719234
51Tryptophan metabolism_Homo sapiens_hsa003800.82708608
52Collecting duct acid secretion_Homo sapiens_hsa049660.81441897
53Phototransduction_Homo sapiens_hsa047440.81114052
54Metabolic pathways_Homo sapiens_hsa011000.80515893
55Rheumatoid arthritis_Homo sapiens_hsa053230.78426058
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.77889953
57RNA transport_Homo sapiens_hsa030130.77083472
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.72253908
59Folate biosynthesis_Homo sapiens_hsa007900.71415745
60Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.70309490
61Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.69536137
62Systemic lupus erythematosus_Homo sapiens_hsa053220.68502441
63Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.67563290
64Hematopoietic cell lineage_Homo sapiens_hsa046400.66529347
65Glutathione metabolism_Homo sapiens_hsa004800.62925132
66Nitrogen metabolism_Homo sapiens_hsa009100.61945847
67Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.60335920
68Ether lipid metabolism_Homo sapiens_hsa005650.59412969
69Chemical carcinogenesis_Homo sapiens_hsa052040.56299880
70Carbon metabolism_Homo sapiens_hsa012000.54624131
71Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.54607595
72Pyruvate metabolism_Homo sapiens_hsa006200.54096327
73Maturity onset diabetes of the young_Homo sapiens_hsa049500.53506545
74Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.53083700
75Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.52424189
76Primary bile acid biosynthesis_Homo sapiens_hsa001200.51262852
77Nicotine addiction_Homo sapiens_hsa050330.48773976
78Fatty acid degradation_Homo sapiens_hsa000710.47960801
79Regulation of autophagy_Homo sapiens_hsa041400.47669234
80Fatty acid metabolism_Homo sapiens_hsa012120.47582393
81Arachidonic acid metabolism_Homo sapiens_hsa005900.45699250
82Caffeine metabolism_Homo sapiens_hsa002320.43591129
83Fat digestion and absorption_Homo sapiens_hsa049750.43218755
84N-Glycan biosynthesis_Homo sapiens_hsa005100.42831128
85Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.42568845
86Retinol metabolism_Homo sapiens_hsa008300.42092730
87Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.41678060
88Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40889775
89Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.40731024
90Steroid hormone biosynthesis_Homo sapiens_hsa001400.40162308
91Biosynthesis of amino acids_Homo sapiens_hsa012300.39069024
92Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.37232169
93Selenocompound metabolism_Homo sapiens_hsa004500.35211716
94Olfactory transduction_Homo sapiens_hsa047400.33196340
95T cell receptor signaling pathway_Homo sapiens_hsa046600.31717613
96Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.30056230
97Pentose and glucuronate interconversions_Homo sapiens_hsa000400.29792990
98Non-homologous end-joining_Homo sapiens_hsa034500.27525167
99Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.26103578
100Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.25799893

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