

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | positive regulation of mitotic metaphase/anaphase transition (GO:0045842) | 9.22606282 |
| 2 | positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101) | 9.22606282 |
| 3 | positive regulation of mitotic sister chromatid separation (GO:1901970) | 9.22606282 |
| 4 | ribosomal small subunit assembly (GO:0000028) | 8.76694759 |
| 5 | negative regulation of Ras GTPase activity (GO:0034261) | 8.54473347 |
| 6 | eosinophil chemotaxis (GO:0048245) | 7.96223087 |
| 7 | negative regulation of T cell receptor signaling pathway (GO:0050860) | 7.94820815 |
| 8 | eosinophil migration (GO:0072677) | 7.19299735 |
| 9 | regulation of sister chromatid cohesion (GO:0007063) | 7.05365178 |
| 10 | fucose catabolic process (GO:0019317) | 6.96980649 |
| 11 | L-fucose metabolic process (GO:0042354) | 6.96980649 |
| 12 | L-fucose catabolic process (GO:0042355) | 6.96980649 |
| 13 | regulation of mononuclear cell migration (GO:0071675) | 6.54614861 |
| 14 | negative regulation of antigen receptor-mediated signaling pathway (GO:0050858) | 6.20720138 |
| 15 | positive regulation of chromosome segregation (GO:0051984) | 6.19323255 |
| 16 | branch elongation of an epithelium (GO:0060602) | 6.14789991 |
| 17 | negative regulation of peptidyl-threonine phosphorylation (GO:0010801) | 6.12097920 |
| 18 | negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037) | 5.67952805 |
| 19 | coenzyme A biosynthetic process (GO:0015937) | 5.60548371 |
| 20 | proteasome assembly (GO:0043248) | 5.59461024 |
| 21 | vesicle fusion (GO:0006906) | 5.50492004 |
| 22 | autophagic vacuole fusion (GO:0000046) | 4.91489833 |
| 23 | regulation of T cell receptor signaling pathway (GO:0050856) | 4.89535971 |
| 24 | macrophage chemotaxis (GO:0048246) | 4.71268936 |
| 25 | double-strand break repair via nonhomologous end joining (GO:0006303) | 4.66500904 |
| 26 | non-recombinational repair (GO:0000726) | 4.66500904 |
| 27 | peptidyl-lysine dimethylation (GO:0018027) | 4.42304102 |
| 28 | localization within membrane (GO:0051668) | 4.31241869 |
| 29 | organ growth (GO:0035265) | 4.25918192 |
| 30 | protein import into peroxisome matrix (GO:0016558) | 4.24360394 |
| 31 | positive regulation of calcium ion import (GO:0090280) | 4.15411716 |
| 32 | establishment of mitotic spindle orientation (GO:0000132) | 4.15361911 |
| 33 | axis elongation (GO:0003401) | 4.12552643 |
| 34 | monocyte chemotaxis (GO:0002548) | 4.11004270 |
| 35 | seminiferous tubule development (GO:0072520) | 3.96916299 |
| 36 | preassembly of GPI anchor in ER membrane (GO:0016254) | 3.95626931 |
| 37 | pantothenate metabolic process (GO:0015939) | 3.89288318 |
| 38 | iron-sulfur cluster assembly (GO:0016226) | 3.84149670 |
| 39 | metallo-sulfur cluster assembly (GO:0031163) | 3.84149670 |
| 40 | fucose metabolic process (GO:0006004) | 3.83262665 |
| 41 | regulation of nitric-oxide synthase biosynthetic process (GO:0051769) | 3.80812975 |
| 42 | ribonucleoside bisphosphate biosynthetic process (GO:0034030) | 3.76841180 |
| 43 | nucleoside bisphosphate biosynthetic process (GO:0033866) | 3.76841180 |
| 44 | purine nucleoside bisphosphate biosynthetic process (GO:0034033) | 3.76841180 |
| 45 | establishment of mitotic spindle localization (GO:0040001) | 3.76637951 |
| 46 | organelle membrane fusion (GO:0090174) | 3.73816265 |
| 47 | detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580) | 3.73000756 |
| 48 | regulation of autophagic vacuole assembly (GO:2000785) | 3.71679221 |
| 49 | oxidative demethylation (GO:0070989) | 3.68365910 |
| 50 | fucosylation (GO:0036065) | 3.65542784 |
| 51 | negative regulation of GTP catabolic process (GO:0033125) | 3.64184514 |
| 52 | negative regulation of GTPase activity (GO:0034260) | 3.64184514 |
| 53 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.59233533 |
| 54 | ATP synthesis coupled proton transport (GO:0015986) | 3.59233533 |
| 55 | coenzyme A metabolic process (GO:0015936) | 3.57656222 |
| 56 | regulation of beta-amyloid formation (GO:1902003) | 3.52438058 |
| 57 | intracellular protein transmembrane import (GO:0044743) | 3.47316136 |
| 58 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.46469552 |
| 59 | termination of RNA polymerase III transcription (GO:0006386) | 3.46469552 |
| 60 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.42735848 |
| 61 | regulation of antigen receptor-mediated signaling pathway (GO:0050854) | 3.41791752 |
| 62 | establishment of spindle orientation (GO:0051294) | 3.38615950 |
| 63 | organelle fusion (GO:0048284) | 3.38321855 |
| 64 | regulation of ER to Golgi vesicle-mediated transport (GO:0060628) | 3.32832959 |
| 65 | negative regulation of macroautophagy (GO:0016242) | 3.31524478 |
| 66 | telomere maintenance via recombination (GO:0000722) | 3.28196952 |
| 67 | acrosome assembly (GO:0001675) | 3.26868691 |
| 68 | DNA deamination (GO:0045006) | 3.25820446 |
| 69 | negative regulation of circadian rhythm (GO:0042754) | 3.25074916 |
| 70 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.15605784 |
| 71 | detection of chemical stimulus involved in sensory perception of taste (GO:0050912) | 3.13779544 |
| 72 | positive chemotaxis (GO:0050918) | 3.09314265 |
| 73 | membrane budding (GO:0006900) | 3.05602613 |
| 74 | RNA methylation (GO:0001510) | 3.05211067 |
| 75 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.04945355 |
| 76 | GTP biosynthetic process (GO:0006183) | 3.03398872 |
| 77 | mitochondrial RNA metabolic process (GO:0000959) | 3.00727610 |
| 78 | regulation of fibroblast growth factor receptor signaling pathway (GO:0040036) | 3.00165053 |
| 79 | regulation of vacuole organization (GO:0044088) | 2.97790289 |
| 80 | imidazole-containing compound metabolic process (GO:0052803) | 2.97186679 |
| 81 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 2.93866265 |
| 82 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 2.93866265 |
| 83 | regulation of cellular amino acid metabolic process (GO:0006521) | 2.92433979 |
| 84 | GPI anchor biosynthetic process (GO:0006506) | 2.91601755 |
| 85 | tRNA modification (GO:0006400) | 2.91555969 |
| 86 | protein neddylation (GO:0045116) | 2.91297988 |
| 87 | ER to Golgi vesicle-mediated transport (GO:0006888) | 2.90235060 |
| 88 | DNA demethylation (GO:0080111) | 2.88530849 |
| 89 | histone H3-K9 methylation (GO:0051567) | 2.86526171 |
| 90 | establishment of protein localization to peroxisome (GO:0072663) | 2.85308205 |
| 91 | protein localization to peroxisome (GO:0072662) | 2.85308205 |
| 92 | protein targeting to peroxisome (GO:0006625) | 2.85308205 |
| 93 | mitotic recombination (GO:0006312) | 2.82030036 |
| 94 | DNA integration (GO:0015074) | 2.81081979 |
| 95 | GPI anchor metabolic process (GO:0006505) | 2.81012378 |
| 96 | 7-methylguanosine mRNA capping (GO:0006370) | 2.77743027 |
| 97 | single-organism membrane fusion (GO:0044801) | 2.77416617 |
| 98 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 2.76924149 |
| 99 | prenylation (GO:0097354) | 11.1662514 |
| 100 | protein prenylation (GO:0018342) | 11.1662514 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 8.41531328 |
| 2 | GATA1_22025678_ChIP-Seq_K562_Human | 5.70467738 |
| 3 | VDR_22108803_ChIP-Seq_LS180_Human | 5.07049799 |
| 4 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.44572678 |
| 5 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.05071625 |
| 6 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 3.49660806 |
| 7 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.96086045 |
| 8 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 2.95060636 |
| 9 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.91575887 |
| 10 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.83464622 |
| 11 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 2.82751987 |
| 12 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.71543058 |
| 13 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 2.70922803 |
| 14 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.57494540 |
| 15 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 2.54261583 |
| 16 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.52217081 |
| 17 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 2.45317481 |
| 18 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.34770935 |
| 19 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 2.31559597 |
| 20 | AR_21572438_ChIP-Seq_LNCaP_Human | 2.25691238 |
| 21 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.07237848 |
| 22 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.99484598 |
| 23 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.94544636 |
| 24 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.93932020 |
| 25 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 1.80306943 |
| 26 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.79422752 |
| 27 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.78961693 |
| 28 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.73164546 |
| 29 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 1.68768713 |
| 30 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.67835539 |
| 31 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.60250216 |
| 32 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.55810633 |
| 33 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 1.52437278 |
| 34 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.49100969 |
| 35 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.48306711 |
| 36 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.46006231 |
| 37 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.36490082 |
| 38 | ZIC3_20872845_ChIP-ChIP_MESCs_Mouse | 1.35626640 |
| 39 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.31315910 |
| 40 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.30795034 |
| 41 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.30395633 |
| 42 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.27686279 |
| 43 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 1.26597978 |
| 44 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 1.26418766 |
| 45 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.25586404 |
| 46 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.25018118 |
| 47 | BCAT_22108803_ChIP-Seq_LS180_Human | 1.20179449 |
| 48 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.16579644 |
| 49 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.14034808 |
| 50 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.09972250 |
| 51 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.09939384 |
| 52 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.09195070 |
| 53 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.05226974 |
| 54 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.02824973 |
| 55 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.02824973 |
| 56 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 0.99570830 |
| 57 | DCP1A_22483619_ChIP-Seq_HELA_Human | 0.97932655 |
| 58 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 0.96990163 |
| 59 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 0.96963006 |
| 60 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.96963006 |
| 61 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 0.94506820 |
| 62 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 0.94251882 |
| 63 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 0.93894732 |
| 64 | NANOG_20526341_ChIP-Seq_ESCs_Human | 0.93477958 |
| 65 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 0.92141978 |
| 66 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 0.91014979 |
| 67 | FOXH1_21741376_ChIP-Seq_EPCs_Human | 0.90853444 |
| 68 | TAF15_26573619_Chip-Seq_HEK293_Human | 0.89862173 |
| 69 | GATA3_26560356_Chip-Seq_TH1_Human | 0.87644338 |
| 70 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.86199409 |
| 71 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 0.85068291 |
| 72 | SOX2_19829295_ChIP-Seq_ESCs_Human | 0.83762896 |
| 73 | NANOG_19829295_ChIP-Seq_ESCs_Human | 0.83762896 |
| 74 | CEBPA_26348894_ChIP-Seq_LIVER_Mouse | 0.83550908 |
| 75 | EZH2_22144423_ChIP-Seq_EOC_Human | 0.83265017 |
| 76 | ERG_20517297_ChIP-Seq_VCAP_Human | 0.83074118 |
| 77 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 0.82542873 |
| 78 | MYC_18940864_ChIP-ChIP_HL60_Human | 0.82325467 |
| 79 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 0.82043281 |
| 80 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 0.81578838 |
| 81 | FUS_26573619_Chip-Seq_HEK293_Human | 0.80480768 |
| 82 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.80465324 |
| 83 | P300_19829295_ChIP-Seq_ESCs_Human | 0.80249294 |
| 84 | RXR_22108803_ChIP-Seq_LS180_Human | 0.79609446 |
| 85 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 0.79502101 |
| 86 | XRN2_22483619_ChIP-Seq_HELA_Human | 0.78355441 |
| 87 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 0.74331366 |
| 88 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 0.74251931 |
| 89 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 0.73629975 |
| 90 | FOXH1_21741376_ChIP-Seq_ESCs_Human | 0.73102121 |
| 91 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 0.72330675 |
| 92 | GATA3_21878914_ChIP-Seq_MCF-7_Human | 0.71063959 |
| 93 | GATA3_21867929_ChIP-Seq_TH1_Mouse | 0.70724077 |
| 94 | RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 0.70182355 |
| 95 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 0.69667479 |
| 96 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 0.68555204 |
| 97 | AR_20517297_ChIP-Seq_VCAP_Human | 0.67205776 |
| 98 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 0.65735602 |
| 99 | TCF4_22108803_ChIP-Seq_LS180_Human | 0.65542031 |
| 100 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 0.65380944 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003303_peritoneal_inflammation | 6.34767170 |
| 2 | MP0006082_CNS_inflammation | 4.18399476 |
| 3 | MP0001919_abnormal_reproductive_system | 3.02459302 |
| 4 | MP0001663_abnormal_digestive_system | 2.96554508 |
| 5 | MP0002163_abnormal_gland_morphology | 2.58602474 |
| 6 | MP0001664_abnormal_digestion | 2.57218482 |
| 7 | MP0000467_abnormal_esophagus_morphology | 2.54383781 |
| 8 | MP0005360_urolithiasis | 2.28228283 |
| 9 | MP0002876_abnormal_thyroid_physiology | 2.26132099 |
| 10 | MP0005381_digestive/alimentary_phenotyp | 2.20282626 |
| 11 | MP0002751_abnormal_autonomic_nervous | 2.19549750 |
| 12 | MP0005389_reproductive_system_phenotype | 2.06353258 |
| 13 | MP0000566_synostosis | 10.1678273 |
| 14 | MP0008058_abnormal_DNA_repair | 1.77176290 |
| 15 | MP0009379_abnormal_foot_pigmentation | 1.75676132 |
| 16 | MP0003115_abnormal_respiratory_system | 1.67645094 |
| 17 | MP0003937_abnormal_limbs/digits/tail_de | 1.60633377 |
| 18 | MP0002102_abnormal_ear_morphology | 1.58140616 |
| 19 | MP0006292_abnormal_olfactory_placode | 1.54029794 |
| 20 | MP0000383_abnormal_hair_follicle | 1.51558763 |
| 21 | MP0005084_abnormal_gallbladder_morpholo | 1.50523874 |
| 22 | MP0005379_endocrine/exocrine_gland_phen | 1.47685967 |
| 23 | MP0003195_calcinosis | 1.44555760 |
| 24 | MP0001293_anophthalmia | 1.42237418 |
| 25 | MP0008875_abnormal_xenobiotic_pharmacok | 1.32306250 |
| 26 | MP0008872_abnormal_physiological_respon | 1.32095764 |
| 27 | MP0003646_muscle_fatigue | 1.28217149 |
| 28 | MP0005671_abnormal_response_to | 1.28105478 |
| 29 | MP0001348_abnormal_lacrimal_gland | 1.26215736 |
| 30 | MP0005166_decreased_susceptibility_to | 1.24370162 |
| 31 | MP0001764_abnormal_homeostasis | 1.19814546 |
| 32 | MP0000490_abnormal_crypts_of | 1.19739646 |
| 33 | MP0002736_abnormal_nociception_after | 1.14723486 |
| 34 | MP0004142_abnormal_muscle_tone | 1.14626792 |
| 35 | MP0000534_abnormal_ureter_morphology | 1.11994890 |
| 36 | MP0001286_abnormal_eye_development | 1.10685071 |
| 37 | MP0000372_irregular_coat_pigmentation | 1.09538560 |
| 38 | MP0006072_abnormal_retinal_apoptosis | 1.08411371 |
| 39 | MP0004145_abnormal_muscle_electrophysio | 1.05711748 |
| 40 | MP0002277_abnormal_respiratory_mucosa | 1.04954761 |
| 41 | MP0005645_abnormal_hypothalamus_physiol | 1.02086857 |
| 42 | MP0010678_abnormal_skin_adnexa | 0.99995101 |
| 43 | MP0001915_intracranial_hemorrhage | 0.99078291 |
| 44 | MP0003763_abnormal_thymus_physiology | 0.92810766 |
| 45 | MP0000026_abnormal_inner_ear | 0.92093159 |
| 46 | MP0001529_abnormal_vocalization | 0.91996672 |
| 47 | MP0008877_abnormal_DNA_methylation | 0.91206546 |
| 48 | MP0001968_abnormal_touch/_nociception | 0.89753760 |
| 49 | MP0001963_abnormal_hearing_physiology | 0.89648063 |
| 50 | MP0005551_abnormal_eye_electrophysiolog | 0.88744318 |
| 51 | MP0003878_abnormal_ear_physiology | 0.88203577 |
| 52 | MP0005377_hearing/vestibular/ear_phenot | 0.88203577 |
| 53 | MP0002210_abnormal_sex_determination | 0.87608528 |
| 54 | MP0001485_abnormal_pinna_reflex | 0.87573591 |
| 55 | MP0005253_abnormal_eye_physiology | 0.86117124 |
| 56 | MP0000358_abnormal_cell_content/ | 0.85020678 |
| 57 | MP0004742_abnormal_vestibular_system | 0.83639930 |
| 58 | MP0005397_hematopoietic_system_phenotyp | 0.83624952 |
| 59 | MP0001545_abnormal_hematopoietic_system | 0.83624952 |
| 60 | MP0002019_abnormal_tumor_incidence | 0.83017711 |
| 61 | MP0004885_abnormal_endolymph | 0.81811538 |
| 62 | MP0006276_abnormal_autonomic_nervous | 0.81802649 |
| 63 | MP0003122_maternal_imprinting | 0.81762392 |
| 64 | MP0002837_dystrophic_cardiac_calcinosis | 0.78909649 |
| 65 | MP0000428_abnormal_craniofacial_morphol | 0.78413119 |
| 66 | MP0001873_stomach_inflammation | 0.77542812 |
| 67 | MP0010155_abnormal_intestine_physiology | 0.76097039 |
| 68 | MP0002184_abnormal_innervation | 0.75300564 |
| 69 | MP0000470_abnormal_stomach_morphology | 0.74772502 |
| 70 | MP0002109_abnormal_limb_morphology | 0.73333015 |
| 71 | MP0000685_abnormal_immune_system | 0.73020423 |
| 72 | MP0005501_abnormal_skin_physiology | 0.68768544 |
| 73 | MP0002234_abnormal_pharynx_morphology | 0.68655142 |
| 74 | MP0001501_abnormal_sleep_pattern | 0.67689755 |
| 75 | MP0005085_abnormal_gallbladder_physiolo | 0.67276104 |
| 76 | MP0003283_abnormal_digestive_organ | 0.67023503 |
| 77 | MP0003252_abnormal_bile_duct | 0.66935946 |
| 78 | MP0003942_abnormal_urinary_system | 0.66313019 |
| 79 | MP0005332_abnormal_amino_acid | 0.65267066 |
| 80 | MP0002938_white_spotting | 0.65062472 |
| 81 | MP0003136_yellow_coat_color | 0.63194941 |
| 82 | MP0003186_abnormal_redox_activity | 0.62733102 |
| 83 | MP0003936_abnormal_reproductive_system | 0.61347471 |
| 84 | MP0004147_increased_porphyrin_level | 0.60554975 |
| 85 | MP0000477_abnormal_intestine_morphology | 0.59407348 |
| 86 | MP0001984_abnormal_olfaction | 0.57013334 |
| 87 | MP0003718_maternal_effect | 0.56595864 |
| 88 | MP0002752_abnormal_somatic_nervous | 0.55645464 |
| 89 | MP0002405_respiratory_system_inflammati | 0.55511242 |
| 90 | MP0001835_abnormal_antigen_presentation | 0.55410640 |
| 91 | MP0000049_abnormal_middle_ear | 0.54666558 |
| 92 | MP0005197_abnormal_uvea_morphology | 0.53857770 |
| 93 | MP0001986_abnormal_taste_sensitivity | 0.53522686 |
| 94 | MP0003453_abnormal_keratinocyte_physiol | 0.53463783 |
| 95 | MP0001119_abnormal_female_reproductive | 0.53379522 |
| 96 | MP0001800_abnormal_humoral_immune | 0.52859315 |
| 97 | MP0005195_abnormal_posterior_eye | 0.52719422 |
| 98 | MP0003121_genomic_imprinting | 0.52258987 |
| 99 | MP0003329_amyloid_beta_deposits | 0.52152728 |
| 100 | MP0003011_delayed_dark_adaptation | 0.51344626 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Abnormality of long-chain fatty-acid metabolism (HP:0010964) | 7.79482478 |
| 2 | Duplicated collecting system (HP:0000081) | 7.05738561 |
| 3 | Abnormality of the renal collecting system (HP:0004742) | 6.43859759 |
| 4 | Large for gestational age (HP:0001520) | 5.81198817 |
| 5 | Long foot (HP:0001833) | 5.54305013 |
| 6 | Abnormality of fatty-acid metabolism (HP:0004359) | 4.71134177 |
| 7 | Adactyly (HP:0009776) | 4.47359156 |
| 8 | Progressive muscle weakness (HP:0003323) | 4.21642465 |
| 9 | Acute necrotizing encephalopathy (HP:0006965) | 4.09292836 |
| 10 | Acute lymphatic leukemia (HP:0006721) | 3.98869979 |
| 11 | Severe muscular hypotonia (HP:0006829) | 3.91461039 |
| 12 | Hypoplastic pelvis (HP:0008839) | 3.87710411 |
| 13 | Ureteral duplication (HP:0000073) | 3.77590492 |
| 14 | Dry hair (HP:0011359) | 3.71308842 |
| 15 | Brushfield spots (HP:0001088) | 3.61133071 |
| 16 | Pulmonary artery stenosis (HP:0004415) | 3.59932601 |
| 17 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.58710231 |
| 18 | Acute encephalopathy (HP:0006846) | 3.57288594 |
| 19 | Ureteral stenosis (HP:0000071) | 3.55315576 |
| 20 | Steatorrhea (HP:0002570) | 3.55056832 |
| 21 | Mitochondrial inheritance (HP:0001427) | 3.52328524 |
| 22 | Progressive macrocephaly (HP:0004481) | 3.33386261 |
| 23 | Broad-based gait (HP:0002136) | 3.30745481 |
| 24 | Increased CSF lactate (HP:0002490) | 3.25813433 |
| 25 | Menstrual irregularities (HP:0000858) | 3.22397990 |
| 26 | Lactic acidosis (HP:0003128) | 3.20283752 |
| 27 | Autoamputation (HP:0001218) | 3.19167330 |
| 28 | Ureteral obstruction (HP:0006000) | 3.15758691 |
| 29 | Increased hepatocellular lipid droplets (HP:0006565) | 3.10142220 |
| 30 | Reduced subcutaneous adipose tissue (HP:0003758) | 2.95288299 |
| 31 | Hepatocellular necrosis (HP:0001404) | 2.94592805 |
| 32 | Lipid accumulation in hepatocytes (HP:0006561) | 2.89036754 |
| 33 | Hepatic necrosis (HP:0002605) | 2.87521901 |
| 34 | Increased serum lactate (HP:0002151) | 2.75456849 |
| 35 | Fat malabsorption (HP:0002630) | 2.74087015 |
| 36 | Hypoplastic nipples (HP:0002557) | 2.70340672 |
| 37 | Decreased muscle mass (HP:0003199) | 2.64121750 |
| 38 | Clubbing of toes (HP:0100760) | 2.62670889 |
| 39 | Cerebral edema (HP:0002181) | 2.48237556 |
| 40 | Exercise intolerance (HP:0003546) | 2.47611771 |
| 41 | Respiratory failure (HP:0002878) | 2.45515063 |
| 42 | Renal Fanconi syndrome (HP:0001994) | 2.43271867 |
| 43 | Congenital stationary night blindness (HP:0007642) | 2.39239926 |
| 44 | Transposition of the great arteries (HP:0001669) | 2.37232622 |
| 45 | Abnormal connection of the cardiac segments (HP:0011545) | 2.37232622 |
| 46 | Abnormal ventriculo-arterial connection (HP:0011563) | 2.37232622 |
| 47 | Sudden death (HP:0001699) | 2.34487377 |
| 48 | Polymicrogyria (HP:0002126) | 2.33895219 |
| 49 | Decreased lacrimation (HP:0000633) | 2.29180152 |
| 50 | Epiphyseal stippling (HP:0010655) | 2.27275526 |
| 51 | Wide intermamillary distance (HP:0006610) | 2.26887372 |
| 52 | CNS demyelination (HP:0007305) | 2.26013026 |
| 53 | Optic disc pallor (HP:0000543) | 2.24997551 |
| 54 | Anhidrosis (HP:0000970) | 2.24732457 |
| 55 | Increased number of teeth (HP:0011069) | 2.22774530 |
| 56 | Rhabdomyolysis (HP:0003201) | 2.21645956 |
| 57 | Abnormal auditory evoked potentials (HP:0006958) | 2.21477854 |
| 58 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 2.16667944 |
| 59 | Palmoplantar hyperkeratosis (HP:0000972) | 2.15315961 |
| 60 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.10718009 |
| 61 | Myoglobinuria (HP:0002913) | 2.08827471 |
| 62 | Anxiety (HP:0000739) | 2.08368374 |
| 63 | Chorioretinal coloboma (HP:0000567) | 2.06912861 |
| 64 | Pendular nystagmus (HP:0012043) | 2.05711457 |
| 65 | 3-Methylglutaconic aciduria (HP:0003535) | 2.02961301 |
| 66 | Palmar hyperkeratosis (HP:0010765) | 1.98621460 |
| 67 | Increased serum pyruvate (HP:0003542) | 1.95922025 |
| 68 | Polyneuropathy (HP:0001271) | 1.94958169 |
| 69 | Exertional dyspnea (HP:0002875) | 1.94874429 |
| 70 | Abnormality of the labia minora (HP:0012880) | 1.94666457 |
| 71 | Female pseudohermaphroditism (HP:0010458) | 1.90505873 |
| 72 | Abnormal rod and cone electroretinograms (HP:0008323) | 1.90108382 |
| 73 | Decreased central vision (HP:0007663) | 1.88029070 |
| 74 | Reticulocytopenia (HP:0001896) | 1.84640943 |
| 75 | Cerebral hypomyelination (HP:0006808) | 1.84268631 |
| 76 | Severe combined immunodeficiency (HP:0004430) | 1.83550350 |
| 77 | Abnormality of urine glucose concentration (HP:0011016) | 1.82959116 |
| 78 | Glycosuria (HP:0003076) | 1.82959116 |
| 79 | Abnormal epiphyseal ossification (HP:0010656) | 1.82792199 |
| 80 | Hypoplastic iliac wings (HP:0002866) | 1.82112324 |
| 81 | Leukodystrophy (HP:0002415) | 1.77526073 |
| 82 | Depressed nasal ridge (HP:0000457) | 1.77052789 |
| 83 | Hypoproteinemia (HP:0003075) | 1.76170852 |
| 84 | Overfolded helix (HP:0000396) | 1.75011813 |
| 85 | Increased intramyocellular lipid droplets (HP:0012240) | 1.74068144 |
| 86 | Abnormality of vision evoked potentials (HP:0000649) | 1.73640068 |
| 87 | Abnormality of cells of the erythroid lineage (HP:0012130) | 1.69084829 |
| 88 | Abnormality of glycolysis (HP:0004366) | 1.68204232 |
| 89 | Plantar hyperkeratosis (HP:0007556) | 1.67677575 |
| 90 | Lethargy (HP:0001254) | 1.67621315 |
| 91 | Pancreatic cysts (HP:0001737) | 1.67221583 |
| 92 | Pancreatic fibrosis (HP:0100732) | 1.65667407 |
| 93 | Spastic tetraplegia (HP:0002510) | 1.64792609 |
| 94 | Hyperglycinemia (HP:0002154) | 1.64097367 |
| 95 | B lymphocytopenia (HP:0010976) | 1.62224956 |
| 96 | Abnormal number of erythroid precursors (HP:0012131) | 1.61827986 |
| 97 | True hermaphroditism (HP:0010459) | 1.61608374 |
| 98 | Thyroiditis (HP:0100646) | 1.60414164 |
| 99 | Large hands (HP:0001176) | 1.60183558 |
| 100 | IgG deficiency (HP:0004315) | 1.59033115 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MKNK1 | 6.37399231 |
| 2 | TAOK2 | 4.69561049 |
| 3 | TAOK1 | 4.60050093 |
| 4 | MAP3K11 | 3.73990857 |
| 5 | MAP3K3 | 3.23524244 |
| 6 | MAP2K3 | 2.90332376 |
| 7 | MKNK2 | 10.9122371 |
| 8 | JAK3 | 1.95289814 |
| 9 | ABL2 | 1.88846853 |
| 10 | VRK2 | 1.67186329 |
| 11 | TLK1 | 1.63992545 |
| 12 | DYRK1A | 1.61355172 |
| 13 | ZAK | 1.49190502 |
| 14 | BUB1 | 1.33385038 |
| 15 | SRPK1 | 1.25341223 |
| 16 | VRK1 | 1.18415112 |
| 17 | WNK4 | 0.97546554 |
| 18 | MAP3K5 | 0.94768778 |
| 19 | CHEK2 | 0.87401392 |
| 20 | TIE1 | 0.81276300 |
| 21 | WNK3 | 0.79005681 |
| 22 | GRK1 | 0.78766197 |
| 23 | TXK | 0.78520993 |
| 24 | MAP4K2 | 0.76866319 |
| 25 | NUAK1 | 0.74801205 |
| 26 | TAF1 | 0.72087073 |
| 27 | ADRBK2 | 0.69300437 |
| 28 | TSSK6 | 0.66228106 |
| 29 | PRKCQ | 0.64834759 |
| 30 | MAP3K8 | 0.55726016 |
| 31 | FRK | 0.55701605 |
| 32 | NEK1 | 0.53250470 |
| 33 | BCKDK | 0.53137168 |
| 34 | PDK2 | 0.52898078 |
| 35 | TRIM28 | 0.50570650 |
| 36 | EIF2AK3 | 0.50043754 |
| 37 | MAP3K1 | 0.47209111 |
| 38 | NME2 | 0.47029620 |
| 39 | PLK3 | 0.45965416 |
| 40 | KDR | 0.45964484 |
| 41 | MAP3K12 | 0.44579306 |
| 42 | STK16 | 0.44142934 |
| 43 | AURKA | 0.44090731 |
| 44 | DYRK2 | 0.40152344 |
| 45 | BMPR1B | 0.39931906 |
| 46 | STK39 | 0.37775369 |
| 47 | DAPK3 | 0.36659895 |
| 48 | NME1 | 0.36323382 |
| 49 | PBK | 0.32851870 |
| 50 | CSNK1A1 | 0.32089453 |
| 51 | PLK4 | 0.31498755 |
| 52 | OXSR1 | 0.30600407 |
| 53 | MST4 | 0.29978847 |
| 54 | INSRR | 0.29758538 |
| 55 | CDC7 | 0.27833987 |
| 56 | CSNK2A2 | 0.27514081 |
| 57 | MYLK | 0.26646388 |
| 58 | CSNK2A1 | 0.23106239 |
| 59 | GRK5 | 0.22119179 |
| 60 | OBSCN | 0.22099286 |
| 61 | PASK | 0.21952960 |
| 62 | PHKG2 | 0.21640766 |
| 63 | PHKG1 | 0.21640766 |
| 64 | MAPK15 | 0.20460398 |
| 65 | LMTK2 | 0.19706763 |
| 66 | DAPK1 | 0.19320181 |
| 67 | RPS6KA5 | 0.19120365 |
| 68 | SMG1 | 0.19043733 |
| 69 | MAP4K1 | 0.18067384 |
| 70 | PRKCG | 0.17755715 |
| 71 | EIF2AK1 | 0.17385673 |
| 72 | CCNB1 | 0.15930719 |
| 73 | IGF1R | 0.15855281 |
| 74 | EIF2AK2 | 0.15499872 |
| 75 | AURKB | 0.15476435 |
| 76 | PLK2 | 0.15390727 |
| 77 | PRKCD | 0.14461697 |
| 78 | PRKCA | 0.14323125 |
| 79 | CSNK1E | 0.13959582 |
| 80 | PRKACA | 0.12871982 |
| 81 | CSNK1G3 | 0.12850243 |
| 82 | STK4 | 0.12731914 |
| 83 | TGFBR1 | 0.12249293 |
| 84 | LIMK1 | 0.11945826 |
| 85 | ABL1 | 0.11360829 |
| 86 | EPHB2 | 0.10795878 |
| 87 | WEE1 | 0.10626260 |
| 88 | EPHA2 | 0.10524121 |
| 89 | GRK7 | 0.10464659 |
| 90 | CDK8 | 0.09224900 |
| 91 | PLK1 | 0.08195172 |
| 92 | CSNK1G2 | 0.08012929 |
| 93 | ADRBK1 | 0.07117356 |
| 94 | ITK | 0.06849200 |
| 95 | MUSK | 0.06725365 |
| 96 | CDK9 | 0.06618699 |
| 97 | CSNK1G1 | 0.06340588 |
| 98 | PINK1 | 0.05762612 |
| 99 | CASK | 0.04416445 |
| 100 | PRKCB | 0.04360632 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 4.32736863 |
| 2 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 4.21169274 |
| 3 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 3.60849364 |
| 4 | RNA polymerase_Homo sapiens_hsa03020 | 3.38908459 |
| 5 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 2.99801013 |
| 6 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.82878074 |
| 7 | Ribosome_Homo sapiens_hsa03010 | 2.67623876 |
| 8 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 2.33325331 |
| 9 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.29300652 |
| 10 | Parkinsons disease_Homo sapiens_hsa05012 | 2.26982913 |
| 11 | Fatty acid elongation_Homo sapiens_hsa00062 | 2.04736747 |
| 12 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.91447662 |
| 13 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.86639844 |
| 14 | Huntingtons disease_Homo sapiens_hsa05016 | 1.85342724 |
| 15 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.80815148 |
| 16 | Protein export_Homo sapiens_hsa03060 | 1.72291964 |
| 17 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 1.66692922 |
| 18 | Tryptophan metabolism_Homo sapiens_hsa00380 | 1.66545839 |
| 19 | Alzheimers disease_Homo sapiens_hsa05010 | 1.53237729 |
| 20 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.49720567 |
| 21 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 1.48621134 |
| 22 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.41172651 |
| 23 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.38456051 |
| 24 | Taste transduction_Homo sapiens_hsa04742 | 1.34426765 |
| 25 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.33859924 |
| 26 | Peroxisome_Homo sapiens_hsa04146 | 1.28500855 |
| 27 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.26864606 |
| 28 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.25890194 |
| 29 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 1.25679126 |
| 30 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.25673026 |
| 31 | Mismatch repair_Homo sapiens_hsa03430 | 1.18216814 |
| 32 | Asthma_Homo sapiens_hsa05310 | 1.16999790 |
| 33 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.15855902 |
| 34 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.15344884 |
| 35 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.14213235 |
| 36 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 1.05242847 |
| 37 | Fatty acid degradation_Homo sapiens_hsa00071 | 1.02830221 |
| 38 | Sulfur relay system_Homo sapiens_hsa04122 | 1.01588628 |
| 39 | DNA replication_Homo sapiens_hsa03030 | 0.99893707 |
| 40 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.99730803 |
| 41 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.98947286 |
| 42 | RNA transport_Homo sapiens_hsa03013 | 0.96336441 |
| 43 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.95006238 |
| 44 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.94612324 |
| 45 | Purine metabolism_Homo sapiens_hsa00230 | 0.92153026 |
| 46 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.91955224 |
| 47 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.90367818 |
| 48 | Basal transcription factors_Homo sapiens_hsa03022 | 0.88665200 |
| 49 | RNA degradation_Homo sapiens_hsa03018 | 0.87731411 |
| 50 | Homologous recombination_Homo sapiens_hsa03440 | 0.87271777 |
| 51 | Allograft rejection_Homo sapiens_hsa05330 | 0.86834759 |
| 52 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.84428966 |
| 53 | Lysine degradation_Homo sapiens_hsa00310 | 0.83274480 |
| 54 | Phototransduction_Homo sapiens_hsa04744 | 0.81435641 |
| 55 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.79532039 |
| 56 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.78266055 |
| 57 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.78124388 |
| 58 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.77137677 |
| 59 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.70409566 |
| 60 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.69951453 |
| 61 | Metabolic pathways_Homo sapiens_hsa01100 | 0.67536059 |
| 62 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.66566237 |
| 63 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.65324702 |
| 64 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.65110221 |
| 65 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.62996624 |
| 66 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.61710743 |
| 67 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.60447597 |
| 68 | Alcoholism_Homo sapiens_hsa05034 | 0.58514001 |
| 69 | Carbon metabolism_Homo sapiens_hsa01200 | 0.58223090 |
| 70 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.57870344 |
| 71 | Retinol metabolism_Homo sapiens_hsa00830 | 0.56700009 |
| 72 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.55342411 |
| 73 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.53925049 |
| 74 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.53067327 |
| 75 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.50385706 |
| 76 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.49647839 |
| 77 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.48394870 |
| 78 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.47847446 |
| 79 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.44263945 |
| 80 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.42525128 |
| 81 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.42095091 |
| 82 | Viral myocarditis_Homo sapiens_hsa05416 | 0.40013299 |
| 83 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.39918554 |
| 84 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.38674080 |
| 85 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.37533275 |
| 86 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.37327438 |
| 87 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.37157971 |
| 88 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.35624345 |
| 89 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.35138926 |
| 90 | Mineral absorption_Homo sapiens_hsa04978 | 0.33797083 |
| 91 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.33774274 |
| 92 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.32781569 |
| 93 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.32471227 |
| 94 | Olfactory transduction_Homo sapiens_hsa04740 | 0.32359366 |
| 95 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.30933855 |
| 96 | Spliceosome_Homo sapiens_hsa03040 | 0.29601337 |
| 97 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.28176185 |
| 98 | Base excision repair_Homo sapiens_hsa03410 | 0.27261430 |
| 99 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.25973034 |
| 100 | Nicotine addiction_Homo sapiens_hsa05033 | 0.25692422 |

