GAPDHP70

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)7.31273518
2regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450916.05189394
3proteasome assembly (GO:0043248)5.50622244
4cytidine deamination (GO:0009972)5.33369380
5cytidine metabolic process (GO:0046087)5.33369380
6cytidine catabolic process (GO:0006216)5.33369380
7ATP synthesis coupled proton transport (GO:0015986)4.65813765
8energy coupled proton transport, down electrochemical gradient (GO:0015985)4.65813765
9mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.65024901
10establishment of protein localization to mitochondrial membrane (GO:0090151)4.59759084
11pyrimidine ribonucleoside catabolic process (GO:0046133)4.50987439
12tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.28028520
13RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.28028520
14negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.27713251
15regulation of cellular amino acid metabolic process (GO:0006521)4.22842432
16DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.11417144
17protein neddylation (GO:0045116)4.04523018
18signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.99190712
19signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.99190712
20signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.99190712
21signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.98362749
22intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.98362749
23positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.95403934
24mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.95165550
25termination of RNA polymerase III transcription (GO:0006386)3.92444825
26transcription elongation from RNA polymerase III promoter (GO:0006385)3.92444825
27chaperone-mediated protein transport (GO:0072321)3.92116086
28water-soluble vitamin biosynthetic process (GO:0042364)3.84796390
29regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.81982583
30signal transduction involved in DNA damage checkpoint (GO:0072422)3.80674566
31signal transduction involved in DNA integrity checkpoint (GO:0072401)3.80674566
32signal transduction involved in cell cycle checkpoint (GO:0072395)3.77165559
33negative regulation of ligase activity (GO:0051352)3.77056417
34negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.77056417
35protein deneddylation (GO:0000338)3.75226770
36protein complex biogenesis (GO:0070271)3.74705892
37respiratory electron transport chain (GO:0022904)3.58376554
38cullin deneddylation (GO:0010388)3.55839588
39nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.55829899
40electron transport chain (GO:0022900)3.55535894
41rRNA modification (GO:0000154)3.53174995
42anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.52245363
43respiratory chain complex IV assembly (GO:0008535)3.49578129
44mannosylation (GO:0097502)3.46887636
45mitochondrial respiratory chain complex assembly (GO:0033108)3.42090625
46mitochondrial respiratory chain complex I assembly (GO:0032981)3.40723444
47NADH dehydrogenase complex assembly (GO:0010257)3.40723444
48mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.40723444
49antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.39789265
50Arp2/3 complex-mediated actin nucleation (GO:0034314)3.39291164
51exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.38600436
52positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.25543928
53cytochrome complex assembly (GO:0017004)3.18552528
54GTP biosynthetic process (GO:0006183)3.14428248
55positive regulation of ligase activity (GO:0051351)3.13819022
56DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.12850117
57antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.10729558
58pseudouridine synthesis (GO:0001522)3.08039605
59positive regulation of cell cycle arrest (GO:0071158)3.07409726
60actin nucleation (GO:0045010)3.03662200
61regulation of cellular amine metabolic process (GO:0033238)3.03130602
62rRNA methylation (GO:0031167)2.98800011
63behavioral response to nicotine (GO:0035095)2.90741396
64preassembly of GPI anchor in ER membrane (GO:0016254)2.89907006
65platelet dense granule organization (GO:0060155)2.89076992
66tRNA processing (GO:0008033)2.87621225
67purine nucleoside triphosphate biosynthetic process (GO:0009145)2.84325189
68L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.81200384
69purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.78757139
70protein targeting to mitochondrion (GO:0006626)2.78086072
71hydrogen ion transmembrane transport (GO:1902600)2.77195267
72intracellular protein transmembrane import (GO:0044743)2.74486763
73regulation of mitochondrial translation (GO:0070129)2.74383854
74negative regulation of telomere maintenance (GO:0032205)2.74190187
75DNA catabolic process, exonucleolytic (GO:0000738)2.71552037
76proton transport (GO:0015992)2.71053200
77ubiquinone biosynthetic process (GO:0006744)2.70645982
78regulation of ubiquitin-protein transferase activity (GO:0051438)2.70391306
79iron-sulfur cluster assembly (GO:0016226)2.70043952
80metallo-sulfur cluster assembly (GO:0031163)2.70043952
81antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.69175994
82regulation of isotype switching to IgG isotypes (GO:0048302)2.68868428
83establishment of protein localization to mitochondrion (GO:0072655)2.68849422
84sequestering of actin monomers (GO:0042989)2.68383941
85branched-chain amino acid catabolic process (GO:0009083)2.67617853
86ATP biosynthetic process (GO:0006754)2.67492578
87positive regulation of defense response to virus by host (GO:0002230)2.67280495
88deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.65031279
89positive regulation of prostaglandin secretion (GO:0032308)2.63794884
90hydrogen transport (GO:0006818)2.63688820
91pyrimidine ribonucleoside metabolic process (GO:0046131)2.63180500
92regulation of ligase activity (GO:0051340)2.62996881
93guanosine-containing compound biosynthetic process (GO:1901070)2.60554939
94protein-cofactor linkage (GO:0018065)2.60459092
95regulation of cell cycle arrest (GO:0071156)2.60440387
96UTP biosynthetic process (GO:0006228)2.60052625
97tRNA metabolic process (GO:0006399)2.59254954
98GPI anchor metabolic process (GO:0006505)2.57869621
99negative regulation of protein ubiquitination (GO:0031397)2.56426829
100protein maturation by protein folding (GO:0022417)2.56109638

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.01999058
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.58867339
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.92425171
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.63983261
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.60275034
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.59172074
7ELF1_17652178_ChIP-ChIP_JURKAT_Human3.50090119
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.33878372
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.99313990
10VDR_23849224_ChIP-Seq_CD4+_Human2.96871096
11CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.61706689
12SRF_21415370_ChIP-Seq_HL-1_Mouse2.58821787
13ELK1_19687146_ChIP-ChIP_HELA_Human2.54335221
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.51619383
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.46653309
16FOXP3_21729870_ChIP-Seq_TREG_Human2.46265721
17ZNF274_21170338_ChIP-Seq_K562_Hela2.35550815
18SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.26425701
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.24797485
20PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.07494941
21VDR_22108803_ChIP-Seq_LS180_Human2.04120564
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.97665983
23CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.92004280
24MYC_18358816_ChIP-ChIP_MESCs_Mouse1.91097736
25MYC_18555785_ChIP-Seq_MESCs_Mouse1.87812426
26E2F4_17652178_ChIP-ChIP_JURKAT_Human1.85626805
27EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.76765085
28DCP1A_22483619_ChIP-Seq_HELA_Human1.75411179
29YY1_21170310_ChIP-Seq_MESCs_Mouse1.74060704
30GABP_19822575_ChIP-Seq_HepG2_Human1.72272063
31MYC_18940864_ChIP-ChIP_HL60_Human1.71439183
32FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.65995739
33HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.64758041
34IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.63482079
35PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58837387
36FLI1_27457419_Chip-Seq_LIVER_Mouse1.58593195
37HOXB4_20404135_ChIP-ChIP_EML_Mouse1.58139382
38NOTCH1_21737748_ChIP-Seq_TLL_Human1.56578237
39BP1_19119308_ChIP-ChIP_Hs578T_Human1.51004658
40E2F1_18555785_ChIP-Seq_MESCs_Mouse1.48625161
41THAP11_20581084_ChIP-Seq_MESCs_Mouse1.45728510
42MYC_19030024_ChIP-ChIP_MESCs_Mouse1.45646946
43FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.44075549
44IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.42904890
45E2F7_22180533_ChIP-Seq_HELA_Human1.42835862
46CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.40116907
47ELK1_22589737_ChIP-Seq_MCF10A_Human1.38403331
48IRF8_22096565_ChIP-ChIP_GC-B_Human1.37835185
49IGF1R_20145208_ChIP-Seq_DFB_Human1.36833564
50TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.36300362
51IRF1_19129219_ChIP-ChIP_H3396_Human1.36253813
52PADI4_21655091_ChIP-ChIP_MCF-7_Human1.35690157
53TP53_22573176_ChIP-Seq_HFKS_Human1.33183143
54ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.30731460
55PCGF2_27294783_Chip-Seq_ESCs_Mouse1.29127208
56PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.28940148
57AR_20517297_ChIP-Seq_VCAP_Human1.26345357
58EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.25423788
59TTF2_22483619_ChIP-Seq_HELA_Human1.24179725
60FOXA1_25329375_ChIP-Seq_VCAP_Human1.23316478
61FOXA1_27270436_Chip-Seq_PROSTATE_Human1.23316478
62EWS_26573619_Chip-Seq_HEK293_Human1.23024804
63SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.20438050
64XRN2_22483619_ChIP-Seq_HELA_Human1.18915674
65GATA3_26560356_Chip-Seq_TH2_Human1.18913724
66CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.15173720
67NELFA_20434984_ChIP-Seq_ESCs_Mouse1.14433038
68EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.09748014
69RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.09705496
70PCGF2_27294783_Chip-Seq_NPCs_Mouse1.09467884
71FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.07311763
72MYB_26560356_Chip-Seq_TH2_Human1.06777733
73GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.04804155
74SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.04571843
75FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03694492
76STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.02282164
77MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.02103123
78ERG_20517297_ChIP-Seq_VCAP_Human1.01994115
79NCOR_22424771_ChIP-Seq_293T_Human1.01596877
80TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.97418975
81IRF8_21731497_ChIP-ChIP_J774_Mouse0.97186951
82YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.96825466
83EGR1_23403033_ChIP-Seq_LIVER_Mouse0.96812047
84AUTS2_25519132_ChIP-Seq_293T-REX_Human0.95796995
85CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.95640673
86GATA3_21878914_ChIP-Seq_MCF-7_Human0.95450195
87MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.94662714
88LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.94480687
89POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.94477881
90MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.94089366
91HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.93497276
92MYC_19829295_ChIP-Seq_ESCs_Human0.92783768
93ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.91425896
94CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.89465652
95NANOG_20526341_ChIP-Seq_ESCs_Human0.89278890
96FUS_26573619_Chip-Seq_HEK293_Human0.87313674
97TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.87070742
98SOX2_19829295_ChIP-Seq_ESCs_Human0.86129684
99NANOG_19829295_ChIP-Seq_ESCs_Human0.86129684
100HOXB7_26014856_ChIP-Seq_BT474_Human0.85325112

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to3.68319404
2MP0008058_abnormal_DNA_repair2.96008551
3MP0004147_increased_porphyrin_level2.87741381
4MP0002102_abnormal_ear_morphology2.67738285
5MP0002163_abnormal_gland_morphology2.57373483
6MP0008875_abnormal_xenobiotic_pharmacok2.48007914
7MP0008877_abnormal_DNA_methylation2.29531572
8MP0006072_abnormal_retinal_apoptosis2.24644802
9MP0003786_premature_aging2.23667820
10MP0009785_altered_susceptibility_to2.22807819
11MP0005084_abnormal_gallbladder_morpholo2.19645984
12MP0002166_altered_tumor_susceptibility2.06924908
13MP0001835_abnormal_antigen_presentation2.06012476
14MP0010094_abnormal_chromosome_stability2.05590596
15MP0002736_abnormal_nociception_after2.03232694
16MP0002006_tumorigenesis2.00460686
17MP0000372_irregular_coat_pigmentation1.96684121
18MP0006036_abnormal_mitochondrial_physio1.89472194
19MP0008872_abnormal_physiological_respon1.81186850
20MP0001529_abnormal_vocalization1.80263418
21MP0001968_abnormal_touch/_nociception1.78360511
22MP0009333_abnormal_splenocyte_physiolog1.74417187
23MP0006035_abnormal_mitochondrial_morpho1.71698684
24MP0003806_abnormal_nucleotide_metabolis1.69654159
25MP0006292_abnormal_olfactory_placode1.63705171
26MP0004957_abnormal_blastocyst_morpholog1.61879446
27MP0002148_abnormal_hypersensitivity_rea1.60758772
28MP0005551_abnormal_eye_electrophysiolog1.58000917
29MP0005379_endocrine/exocrine_gland_phen1.51121324
30MP0000685_abnormal_immune_system1.50619403
31MP0001905_abnormal_dopamine_level1.49252408
32MP0003186_abnormal_redox_activity1.45977589
33MP0003763_abnormal_thymus_physiology1.44461774
34MP0005645_abnormal_hypothalamus_physiol1.44411970
35MP0001800_abnormal_humoral_immune1.41188938
36MP0001984_abnormal_olfaction1.37510011
37MP0005075_abnormal_melanosome_morpholog1.37496188
38MP0003718_maternal_effect1.37300064
39MP0005253_abnormal_eye_physiology1.34578453
40MP0003195_calcinosis1.31478376
41MP0004142_abnormal_muscle_tone1.27791555
42MP0005000_abnormal_immune_tolerance1.21397759
43MP0002837_dystrophic_cardiac_calcinosis1.20992716
44MP0005389_reproductive_system_phenotype1.18848109
45MP0003950_abnormal_plasma_membrane1.18591996
46MP0004145_abnormal_muscle_electrophysio1.17150451
47MP0001501_abnormal_sleep_pattern1.17047168
48MP0001764_abnormal_homeostasis1.16568495
49MP0005410_abnormal_fertilization1.16204061
50MP0005387_immune_system_phenotype1.14092328
51MP0001790_abnormal_immune_system1.14092328
52MP0002138_abnormal_hepatobiliary_system1.13331091
53MP0002723_abnormal_immune_serum1.13088584
54MP0002933_joint_inflammation1.12877760
55MP0006276_abnormal_autonomic_nervous1.12020230
56MP0002420_abnormal_adaptive_immunity1.09819215
57MP0006054_spinal_hemorrhage1.09070987
58MP0003646_muscle_fatigue1.08874212
59MP0001819_abnormal_immune_cell1.08263992
60MP0002876_abnormal_thyroid_physiology1.07772872
61MP0003866_abnormal_defecation1.07436123
62MP0005167_abnormal_blood-brain_barrier1.06065091
63MP0002938_white_spotting1.05625115
64MP0003011_delayed_dark_adaptation1.05611143
65MP0008789_abnormal_olfactory_epithelium1.00531637
66MP0001919_abnormal_reproductive_system0.97942217
67MP0005025_abnormal_response_to0.96749922
68MP0002452_abnormal_antigen_presenting0.96017657
69MP0003252_abnormal_bile_duct0.95101545
70MP0002160_abnormal_reproductive_system0.94043092
71MP0002234_abnormal_pharynx_morphology0.93896243
72MP0005085_abnormal_gallbladder_physiolo0.92878830
73MP0001873_stomach_inflammation0.91299627
74MP0009764_decreased_sensitivity_to0.90932394
75MP0000689_abnormal_spleen_morphology0.90361962
76MP0000647_abnormal_sebaceous_gland0.90252117
77MP0002693_abnormal_pancreas_physiology0.90243243
78MP0008007_abnormal_cellular_replicative0.88217883
79MP0001293_anophthalmia0.88100150
80MP0001485_abnormal_pinna_reflex0.86250896
81MP0005636_abnormal_mineral_homeostasis0.85656662
82MP0000358_abnormal_cell_content/0.84539382
83MP0008775_abnormal_heart_ventricle0.84364769
84MP0002277_abnormal_respiratory_mucosa0.84120766
85MP0002095_abnormal_skin_pigmentation0.84062056
86MP0009745_abnormal_behavioral_response0.82620954
87MP0003693_abnormal_embryo_hatching0.82491880
88MP0000716_abnormal_immune_system0.82341271
89MP0002398_abnormal_bone_marrow0.82140113
90MP0002132_abnormal_respiratory_system0.81906176
91MP0001986_abnormal_taste_sensitivity0.81227315
92MP0003567_abnormal_fetal_cardiomyocyte0.80993504
93MP0003787_abnormal_imprinting0.79281622
94MP0009046_muscle_twitch0.77526097
95MP0000427_abnormal_hair_cycle0.77123561
96MP0003137_abnormal_impulse_conducting0.75732856
97MP0002019_abnormal_tumor_incidence0.75388271
98MP0001845_abnormal_inflammatory_respons0.75315354
99MP0001119_abnormal_female_reproductive0.74778420
100MP0000703_abnormal_thymus_morphology0.74471917

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.80944525
2Mitochondrial inheritance (HP:0001427)4.55953145
3Hepatocellular necrosis (HP:0001404)4.37976708
4Abnormal mitochondria in muscle tissue (HP:0008316)4.36288520
5Increased CSF lactate (HP:0002490)4.22390893
6Acute encephalopathy (HP:0006846)4.11303037
7Progressive macrocephaly (HP:0004481)3.95786690
8Hepatic necrosis (HP:0002605)3.94138422
9IgG deficiency (HP:0004315)3.66576835
10Severe combined immunodeficiency (HP:0004430)3.38575369
11Pancreatic cysts (HP:0001737)3.35052954
12Increased hepatocellular lipid droplets (HP:0006565)3.34130737
133-Methylglutaconic aciduria (HP:0003535)3.22763421
14Increased serum lactate (HP:0002151)3.11900162
15Aplastic anemia (HP:0001915)3.10413419
16Hypoproteinemia (HP:0003075)3.09502957
17Lipid accumulation in hepatocytes (HP:0006561)3.09186614
18Type I transferrin isoform profile (HP:0003642)3.07295675
19Cerebral edema (HP:0002181)3.04649423
20Pancreatic fibrosis (HP:0100732)3.03965158
21B lymphocytopenia (HP:0010976)2.97729866
22True hermaphroditism (HP:0010459)2.93168232
23Abnormality of B cell number (HP:0010975)2.88566782
24Renal Fanconi syndrome (HP:0001994)2.75659260
25Thyroiditis (HP:0100646)2.71800254
26Lactic acidosis (HP:0003128)2.71308602
27T lymphocytopenia (HP:0005403)2.66823349
28Combined immunodeficiency (HP:0005387)2.65252364
29Pancytopenia (HP:0001876)2.62654446
30Optic disc pallor (HP:0000543)2.59849143
31Decreased activity of mitochondrial respiratory chain (HP:0008972)2.58666207
32Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.58666207
33Abnormal protein glycosylation (HP:0012346)2.58546688
34Abnormal glycosylation (HP:0012345)2.58546688
35Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.58546688
36Abnormal protein N-linked glycosylation (HP:0012347)2.58546688
37Abnormality of the pons (HP:0007361)2.53144777
38Increased intramyocellular lipid droplets (HP:0012240)2.52602684
39Respiratory failure (HP:0002878)2.52124579
40Methylmalonic aciduria (HP:0012120)2.50730304
41Abnormality of midbrain morphology (HP:0002418)2.47383660
42Molar tooth sign on MRI (HP:0002419)2.47383660
43Congenital, generalized hypertrichosis (HP:0004540)2.45772174
44CNS demyelination (HP:0007305)2.43807337
45Abnormality of T cell number (HP:0011839)2.40286881
46Abolished electroretinogram (ERG) (HP:0000550)2.39947457
47Decreased electroretinogram (ERG) amplitude (HP:0000654)2.37315976
48Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.35817410
49Exercise intolerance (HP:0003546)2.31534897
50Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.30556237
51Aplasia/hypoplasia of the uterus (HP:0008684)2.28166776
52Type II lissencephaly (HP:0007260)2.28073416
53Increased IgM level (HP:0003496)2.27507072
54Oral leukoplakia (HP:0002745)2.27168964
55Renal cortical cysts (HP:0000803)2.26859532
56Hypoplasia of the pons (HP:0012110)2.24267718
57Abnormality of T cells (HP:0002843)2.23025310
58Stomatitis (HP:0010280)2.22906248
59Abnormality of the renal cortex (HP:0011035)2.21564326
60Lethargy (HP:0001254)2.21179927
61Methylmalonic acidemia (HP:0002912)2.20873988
62Nephronophthisis (HP:0000090)2.20512730
63Abnormality of eosinophils (HP:0001879)2.17111037
64Elevated erythrocyte sedimentation rate (HP:0003565)2.16563984
65Abnormality of alanine metabolism (HP:0010916)2.14346664
66Hyperalaninemia (HP:0003348)2.14346664
67Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.14346664
68Exertional dyspnea (HP:0002875)2.12978438
69Congenital stationary night blindness (HP:0007642)2.10180563
70Increased muscle lipid content (HP:0009058)2.06749293
71Leukodystrophy (HP:0002415)2.05972475
72Pendular nystagmus (HP:0012043)2.02236909
73Sclerocornea (HP:0000647)2.01262765
74Abnormality of the renal collecting system (HP:0004742)2.01014693
75Progressive microcephaly (HP:0000253)1.99864160
76Duplicated collecting system (HP:0000081)1.97669339
77Eosinophilia (HP:0001880)1.96749266
78Hypoplasia of the thymus (HP:0000778)1.95806408
79Cerebral hypomyelination (HP:0006808)1.93816613
80Medial flaring of the eyebrow (HP:0010747)1.93080595
81Abnormality of dicarboxylic acid metabolism (HP:0010995)1.92775849
82Dicarboxylic aciduria (HP:0003215)1.92775849
83Emotional lability (HP:0000712)1.92320089
84Attenuation of retinal blood vessels (HP:0007843)1.90341994
85Panhypogammaglobulinemia (HP:0003139)1.87660396
86Cellular immunodeficiency (HP:0005374)1.81864303
87Large for gestational age (HP:0001520)1.81721444
88Retinal dysplasia (HP:0007973)1.79525211
89IgM deficiency (HP:0002850)1.78594818
90Generalized aminoaciduria (HP:0002909)1.76751890
91Reduced antithrombin III activity (HP:0001976)1.74094536
92Erythroderma (HP:0001019)1.73105692
93Aplasia/Hypoplasia of the tongue (HP:0010295)1.72593038
94Hypoplasia of the uterus (HP:0000013)1.72365841
95Constricted visual fields (HP:0001133)1.71680075
96Opisthotonus (HP:0002179)1.70862685
97Cerebral palsy (HP:0100021)1.70430075
98Postaxial foot polydactyly (HP:0001830)1.70273750
99Colon cancer (HP:0003003)1.69944214
100Abnormality of the renal medulla (HP:0100957)1.69681431

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.28692580
2TXK3.91746746
3TESK23.07742802
4ZAK3.04507888
5TLK12.95609586
6BUB12.93791530
7BCKDK2.81921860
8KDR2.60810400
9VRK12.51655039
10MST42.39700001
11TESK12.37146264
12LIMK12.18273026
13NUAK12.10160626
14MAP4K22.09034129
15NEK11.76079329
16TRIM281.73690456
17EIF2AK31.71291555
18FRK1.69319545
19MAP3K121.62233806
20DAPK11.58066179
21ADRBK21.57614235
22SRPK11.53890050
23STK161.50742128
24GRK11.48036504
25EIF2AK11.40221262
26BMPR1B1.37926613
27TAOK31.37330141
28CSNK1G31.31526939
29TSSK61.30372070
30WNK41.19890162
31PLK31.16225985
32CSNK1G11.07887310
33CSNK1G21.06923241
34NME11.06172198
35TAF11.04364253
36GRK71.03623292
37CSNK1A1L1.02923267
38CAMKK21.02575858
39TIE11.02101901
40MAPKAPK30.99032315
41PDK20.98579496
42ITK0.94268137
43WNK30.90106188
44EIF2AK20.89885549
45MAP4K10.87180993
46RPS6KA40.85384189
47DYRK20.80834473
48PIK3CG0.80766925
49GRK50.78784442
50PLK20.77193302
51PINK10.76531227
52INSRR0.75629592
53SCYL20.72817077
54STK390.70666052
55PBK0.70445333
56CDK190.69753754
57IKBKE0.69143027
58PHKG20.68738927
59PHKG10.68738927
60OXSR10.66166532
61AURKA0.65300139
62MAP2K60.64938330
63MYLK0.64874838
64RPS6KA50.64581329
65CDC70.62852428
66PRKCQ0.60446347
67IKBKB0.59635200
68LMTK20.55900691
69MAP2K70.55321181
70BCR0.54406324
71PLK10.53055896
72ADRBK10.52076237
73AURKB0.50769750
74SYK0.45889557
75MAPK130.43759663
76STK100.43371868
77LCK0.43213389
78ERBB30.42086654
79DAPK20.41849443
80ATR0.41577942
81CSNK2A10.39236587
82KIT0.39087020
83CSNK1A10.38071841
84FES0.37116582
85TEC0.35538092
86DAPK30.34115044
87PRKCG0.32746318
88WEE10.31575692
89NME20.31263004
90CSNK2A20.31072386
91PAK30.29966666
92PLK40.29083846
93LYN0.28809832
94PTK2B0.28354209
95OBSCN0.28341186
96IGF1R0.28180370
97TBK10.27780105
98MINK10.27560554
99PRKCE0.26997038
100PAK10.26236318

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.14405082
2Oxidative phosphorylation_Homo sapiens_hsa001903.55585800
3Parkinsons disease_Homo sapiens_hsa050122.95166329
4RNA polymerase_Homo sapiens_hsa030202.92563836
5Protein export_Homo sapiens_hsa030602.78377564
6Primary immunodeficiency_Homo sapiens_hsa053402.38252059
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.19981323
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.10560809
9DNA replication_Homo sapiens_hsa030302.05730629
10Huntingtons disease_Homo sapiens_hsa050162.01189533
11Alzheimers disease_Homo sapiens_hsa050101.96702556
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.89008391
13Ribosome_Homo sapiens_hsa030101.88731901
14Homologous recombination_Homo sapiens_hsa034401.88041576
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.80215520
16Non-homologous end-joining_Homo sapiens_hsa034501.77496091
17Mismatch repair_Homo sapiens_hsa034301.72135193
18Pyrimidine metabolism_Homo sapiens_hsa002401.64299972
19Propanoate metabolism_Homo sapiens_hsa006401.55756776
20Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.53209138
21Nucleotide excision repair_Homo sapiens_hsa034201.51783569
22Base excision repair_Homo sapiens_hsa034101.47188558
23RNA degradation_Homo sapiens_hsa030181.45159044
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.44263777
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.38866318
26Basal transcription factors_Homo sapiens_hsa030221.33119021
27Fatty acid elongation_Homo sapiens_hsa000621.31169312
28Cardiac muscle contraction_Homo sapiens_hsa042601.30079924
29Fanconi anemia pathway_Homo sapiens_hsa034601.28386039
30One carbon pool by folate_Homo sapiens_hsa006701.22353252
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.21582432
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.21066406
33Sulfur metabolism_Homo sapiens_hsa009201.20923998
34Peroxisome_Homo sapiens_hsa041461.19221802
35Spliceosome_Homo sapiens_hsa030401.16125481
36Purine metabolism_Homo sapiens_hsa002301.16037132
37Antigen processing and presentation_Homo sapiens_hsa046121.15853020
38Allograft rejection_Homo sapiens_hsa053301.15743317
39Butanoate metabolism_Homo sapiens_hsa006501.12839266
40Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.11522887
41Phototransduction_Homo sapiens_hsa047441.10668411
42Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.09622076
43Autoimmune thyroid disease_Homo sapiens_hsa053201.06936145
44Graft-versus-host disease_Homo sapiens_hsa053321.03511891
45Pyruvate metabolism_Homo sapiens_hsa006201.01761755
46Nitrogen metabolism_Homo sapiens_hsa009101.00870625
47RNA transport_Homo sapiens_hsa030131.00130609
48alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.98825386
49Linoleic acid metabolism_Homo sapiens_hsa005910.95076309
50Steroid biosynthesis_Homo sapiens_hsa001000.93477667
51Cysteine and methionine metabolism_Homo sapiens_hsa002700.89050066
52Intestinal immune network for IgA production_Homo sapiens_hsa046720.87458758
53Type I diabetes mellitus_Homo sapiens_hsa049400.85519166
54Selenocompound metabolism_Homo sapiens_hsa004500.84214990
55Glutathione metabolism_Homo sapiens_hsa004800.83362332
56Caffeine metabolism_Homo sapiens_hsa002320.83334601
57Tryptophan metabolism_Homo sapiens_hsa003800.80270164
58Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.79622341
59Hematopoietic cell lineage_Homo sapiens_hsa046400.78369620
60Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.77799178
61Metabolic pathways_Homo sapiens_hsa011000.77541726
622-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.77366824
63Vitamin B6 metabolism_Homo sapiens_hsa007500.76690975
64Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.76070977
65Regulation of autophagy_Homo sapiens_hsa041400.74734187
66Asthma_Homo sapiens_hsa053100.73799219
67Rheumatoid arthritis_Homo sapiens_hsa053230.70362694
68Folate biosynthesis_Homo sapiens_hsa007900.69214760
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.68440936
70Carbon metabolism_Homo sapiens_hsa012000.67552572
71Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.62357984
72Sulfur relay system_Homo sapiens_hsa041220.62200653
73Chemical carcinogenesis_Homo sapiens_hsa052040.61145850
74Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.60817212
75Systemic lupus erythematosus_Homo sapiens_hsa053220.59880237
76Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.57311307
77Primary bile acid biosynthesis_Homo sapiens_hsa001200.55867055
78Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55508880
79Collecting duct acid secretion_Homo sapiens_hsa049660.55452516
80Biosynthesis of amino acids_Homo sapiens_hsa012300.55093147
81Maturity onset diabetes of the young_Homo sapiens_hsa049500.53500839
82Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.51993756
83Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.50500814
84Fatty acid metabolism_Homo sapiens_hsa012120.49682211
85Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.49508610
86Arachidonic acid metabolism_Homo sapiens_hsa005900.48091576
87Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.47380563
88Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.46344954
89Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.43678911
90Fatty acid degradation_Homo sapiens_hsa000710.43677987
91N-Glycan biosynthesis_Homo sapiens_hsa005100.43620435
92Ether lipid metabolism_Homo sapiens_hsa005650.42953997
93Steroid hormone biosynthesis_Homo sapiens_hsa001400.42721454
94Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.42417001
95Retinol metabolism_Homo sapiens_hsa008300.39817410
96Pentose and glucuronate interconversions_Homo sapiens_hsa000400.39238856
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37718814
98Epstein-Barr virus infection_Homo sapiens_hsa051690.37048029
99Drug metabolism - other enzymes_Homo sapiens_hsa009830.34973681
100Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.32952957

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