

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA deamination (GO:0045006) | 7.31273518 |
| 2 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 6.05189394 |
| 3 | proteasome assembly (GO:0043248) | 5.50622244 |
| 4 | cytidine deamination (GO:0009972) | 5.33369380 |
| 5 | cytidine metabolic process (GO:0046087) | 5.33369380 |
| 6 | cytidine catabolic process (GO:0006216) | 5.33369380 |
| 7 | ATP synthesis coupled proton transport (GO:0015986) | 4.65813765 |
| 8 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 4.65813765 |
| 9 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 4.65024901 |
| 10 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.59759084 |
| 11 | pyrimidine ribonucleoside catabolic process (GO:0046133) | 4.50987439 |
| 12 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 4.28028520 |
| 13 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 4.28028520 |
| 14 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.27713251 |
| 15 | regulation of cellular amino acid metabolic process (GO:0006521) | 4.22842432 |
| 16 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 4.11417144 |
| 17 | protein neddylation (GO:0045116) | 4.04523018 |
| 18 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.99190712 |
| 19 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.99190712 |
| 20 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.99190712 |
| 21 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.98362749 |
| 22 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.98362749 |
| 23 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.95403934 |
| 24 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.95165550 |
| 25 | termination of RNA polymerase III transcription (GO:0006386) | 3.92444825 |
| 26 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.92444825 |
| 27 | chaperone-mediated protein transport (GO:0072321) | 3.92116086 |
| 28 | water-soluble vitamin biosynthetic process (GO:0042364) | 3.84796390 |
| 29 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.81982583 |
| 30 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.80674566 |
| 31 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.80674566 |
| 32 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.77165559 |
| 33 | negative regulation of ligase activity (GO:0051352) | 3.77056417 |
| 34 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.77056417 |
| 35 | protein deneddylation (GO:0000338) | 3.75226770 |
| 36 | protein complex biogenesis (GO:0070271) | 3.74705892 |
| 37 | respiratory electron transport chain (GO:0022904) | 3.58376554 |
| 38 | cullin deneddylation (GO:0010388) | 3.55839588 |
| 39 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.55829899 |
| 40 | electron transport chain (GO:0022900) | 3.55535894 |
| 41 | rRNA modification (GO:0000154) | 3.53174995 |
| 42 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.52245363 |
| 43 | respiratory chain complex IV assembly (GO:0008535) | 3.49578129 |
| 44 | mannosylation (GO:0097502) | 3.46887636 |
| 45 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.42090625 |
| 46 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.40723444 |
| 47 | NADH dehydrogenase complex assembly (GO:0010257) | 3.40723444 |
| 48 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.40723444 |
| 49 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.39789265 |
| 50 | Arp2/3 complex-mediated actin nucleation (GO:0034314) | 3.39291164 |
| 51 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.38600436 |
| 52 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.25543928 |
| 53 | cytochrome complex assembly (GO:0017004) | 3.18552528 |
| 54 | GTP biosynthetic process (GO:0006183) | 3.14428248 |
| 55 | positive regulation of ligase activity (GO:0051351) | 3.13819022 |
| 56 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 3.12850117 |
| 57 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 3.10729558 |
| 58 | pseudouridine synthesis (GO:0001522) | 3.08039605 |
| 59 | positive regulation of cell cycle arrest (GO:0071158) | 3.07409726 |
| 60 | actin nucleation (GO:0045010) | 3.03662200 |
| 61 | regulation of cellular amine metabolic process (GO:0033238) | 3.03130602 |
| 62 | rRNA methylation (GO:0031167) | 2.98800011 |
| 63 | behavioral response to nicotine (GO:0035095) | 2.90741396 |
| 64 | preassembly of GPI anchor in ER membrane (GO:0016254) | 2.89907006 |
| 65 | platelet dense granule organization (GO:0060155) | 2.89076992 |
| 66 | tRNA processing (GO:0008033) | 2.87621225 |
| 67 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 2.84325189 |
| 68 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 2.81200384 |
| 69 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 2.78757139 |
| 70 | protein targeting to mitochondrion (GO:0006626) | 2.78086072 |
| 71 | hydrogen ion transmembrane transport (GO:1902600) | 2.77195267 |
| 72 | intracellular protein transmembrane import (GO:0044743) | 2.74486763 |
| 73 | regulation of mitochondrial translation (GO:0070129) | 2.74383854 |
| 74 | negative regulation of telomere maintenance (GO:0032205) | 2.74190187 |
| 75 | DNA catabolic process, exonucleolytic (GO:0000738) | 2.71552037 |
| 76 | proton transport (GO:0015992) | 2.71053200 |
| 77 | ubiquinone biosynthetic process (GO:0006744) | 2.70645982 |
| 78 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 2.70391306 |
| 79 | iron-sulfur cluster assembly (GO:0016226) | 2.70043952 |
| 80 | metallo-sulfur cluster assembly (GO:0031163) | 2.70043952 |
| 81 | antigen processing and presentation of peptide antigen via MHC class I (GO:0002474) | 2.69175994 |
| 82 | regulation of isotype switching to IgG isotypes (GO:0048302) | 2.68868428 |
| 83 | establishment of protein localization to mitochondrion (GO:0072655) | 2.68849422 |
| 84 | sequestering of actin monomers (GO:0042989) | 2.68383941 |
| 85 | branched-chain amino acid catabolic process (GO:0009083) | 2.67617853 |
| 86 | ATP biosynthetic process (GO:0006754) | 2.67492578 |
| 87 | positive regulation of defense response to virus by host (GO:0002230) | 2.67280495 |
| 88 | deoxyribonucleoside triphosphate metabolic process (GO:0009200) | 2.65031279 |
| 89 | positive regulation of prostaglandin secretion (GO:0032308) | 2.63794884 |
| 90 | hydrogen transport (GO:0006818) | 2.63688820 |
| 91 | pyrimidine ribonucleoside metabolic process (GO:0046131) | 2.63180500 |
| 92 | regulation of ligase activity (GO:0051340) | 2.62996881 |
| 93 | guanosine-containing compound biosynthetic process (GO:1901070) | 2.60554939 |
| 94 | protein-cofactor linkage (GO:0018065) | 2.60459092 |
| 95 | regulation of cell cycle arrest (GO:0071156) | 2.60440387 |
| 96 | UTP biosynthetic process (GO:0006228) | 2.60052625 |
| 97 | tRNA metabolic process (GO:0006399) | 2.59254954 |
| 98 | GPI anchor metabolic process (GO:0006505) | 2.57869621 |
| 99 | negative regulation of protein ubiquitination (GO:0031397) | 2.56426829 |
| 100 | protein maturation by protein folding (GO:0022417) | 2.56109638 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 5.01999058 |
| 2 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.58867339 |
| 3 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.92425171 |
| 4 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.63983261 |
| 5 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.60275034 |
| 6 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.59172074 |
| 7 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 3.50090119 |
| 8 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.33878372 |
| 9 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.99313990 |
| 10 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.96871096 |
| 11 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.61706689 |
| 12 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.58821787 |
| 13 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.54335221 |
| 14 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.51619383 |
| 15 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 2.46653309 |
| 16 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.46265721 |
| 17 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.35550815 |
| 18 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.26425701 |
| 19 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 2.24797485 |
| 20 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.07494941 |
| 21 | VDR_22108803_ChIP-Seq_LS180_Human | 2.04120564 |
| 22 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.97665983 |
| 23 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.92004280 |
| 24 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.91097736 |
| 25 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 1.87812426 |
| 26 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.85626805 |
| 27 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.76765085 |
| 28 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.75411179 |
| 29 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.74060704 |
| 30 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.72272063 |
| 31 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.71439183 |
| 32 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.65995739 |
| 33 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.64758041 |
| 34 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.63482079 |
| 35 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.58837387 |
| 36 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.58593195 |
| 37 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.58139382 |
| 38 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.56578237 |
| 39 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.51004658 |
| 40 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.48625161 |
| 41 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.45728510 |
| 42 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.45646946 |
| 43 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.44075549 |
| 44 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 1.42904890 |
| 45 | E2F7_22180533_ChIP-Seq_HELA_Human | 1.42835862 |
| 46 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.40116907 |
| 47 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.38403331 |
| 48 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 1.37835185 |
| 49 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.36833564 |
| 50 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.36300362 |
| 51 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.36253813 |
| 52 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.35690157 |
| 53 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.33183143 |
| 54 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.30731460 |
| 55 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.29127208 |
| 56 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 1.28940148 |
| 57 | AR_20517297_ChIP-Seq_VCAP_Human | 1.26345357 |
| 58 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.25423788 |
| 59 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.24179725 |
| 60 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.23316478 |
| 61 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.23316478 |
| 62 | EWS_26573619_Chip-Seq_HEK293_Human | 1.23024804 |
| 63 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.20438050 |
| 64 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.18915674 |
| 65 | GATA3_26560356_Chip-Seq_TH2_Human | 1.18913724 |
| 66 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.15173720 |
| 67 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.14433038 |
| 68 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 1.09748014 |
| 69 | RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 1.09705496 |
| 70 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.09467884 |
| 71 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.07311763 |
| 72 | MYB_26560356_Chip-Seq_TH2_Human | 1.06777733 |
| 73 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.04804155 |
| 74 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.04571843 |
| 75 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.03694492 |
| 76 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 1.02282164 |
| 77 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.02103123 |
| 78 | ERG_20517297_ChIP-Seq_VCAP_Human | 1.01994115 |
| 79 | NCOR_22424771_ChIP-Seq_293T_Human | 1.01596877 |
| 80 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.97418975 |
| 81 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 0.97186951 |
| 82 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 0.96825466 |
| 83 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 0.96812047 |
| 84 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 0.95796995 |
| 85 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.95640673 |
| 86 | GATA3_21878914_ChIP-Seq_MCF-7_Human | 0.95450195 |
| 87 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 0.94662714 |
| 88 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.94480687 |
| 89 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 0.94477881 |
| 90 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 0.94089366 |
| 91 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.93497276 |
| 92 | MYC_19829295_ChIP-Seq_ESCs_Human | 0.92783768 |
| 93 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.91425896 |
| 94 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 0.89465652 |
| 95 | NANOG_20526341_ChIP-Seq_ESCs_Human | 0.89278890 |
| 96 | FUS_26573619_Chip-Seq_HEK293_Human | 0.87313674 |
| 97 | TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.87070742 |
| 98 | SOX2_19829295_ChIP-Seq_ESCs_Human | 0.86129684 |
| 99 | NANOG_19829295_ChIP-Seq_ESCs_Human | 0.86129684 |
| 100 | HOXB7_26014856_ChIP-Seq_BT474_Human | 0.85325112 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0005671_abnormal_response_to | 3.68319404 |
| 2 | MP0008058_abnormal_DNA_repair | 2.96008551 |
| 3 | MP0004147_increased_porphyrin_level | 2.87741381 |
| 4 | MP0002102_abnormal_ear_morphology | 2.67738285 |
| 5 | MP0002163_abnormal_gland_morphology | 2.57373483 |
| 6 | MP0008875_abnormal_xenobiotic_pharmacok | 2.48007914 |
| 7 | MP0008877_abnormal_DNA_methylation | 2.29531572 |
| 8 | MP0006072_abnormal_retinal_apoptosis | 2.24644802 |
| 9 | MP0003786_premature_aging | 2.23667820 |
| 10 | MP0009785_altered_susceptibility_to | 2.22807819 |
| 11 | MP0005084_abnormal_gallbladder_morpholo | 2.19645984 |
| 12 | MP0002166_altered_tumor_susceptibility | 2.06924908 |
| 13 | MP0001835_abnormal_antigen_presentation | 2.06012476 |
| 14 | MP0010094_abnormal_chromosome_stability | 2.05590596 |
| 15 | MP0002736_abnormal_nociception_after | 2.03232694 |
| 16 | MP0002006_tumorigenesis | 2.00460686 |
| 17 | MP0000372_irregular_coat_pigmentation | 1.96684121 |
| 18 | MP0006036_abnormal_mitochondrial_physio | 1.89472194 |
| 19 | MP0008872_abnormal_physiological_respon | 1.81186850 |
| 20 | MP0001529_abnormal_vocalization | 1.80263418 |
| 21 | MP0001968_abnormal_touch/_nociception | 1.78360511 |
| 22 | MP0009333_abnormal_splenocyte_physiolog | 1.74417187 |
| 23 | MP0006035_abnormal_mitochondrial_morpho | 1.71698684 |
| 24 | MP0003806_abnormal_nucleotide_metabolis | 1.69654159 |
| 25 | MP0006292_abnormal_olfactory_placode | 1.63705171 |
| 26 | MP0004957_abnormal_blastocyst_morpholog | 1.61879446 |
| 27 | MP0002148_abnormal_hypersensitivity_rea | 1.60758772 |
| 28 | MP0005551_abnormal_eye_electrophysiolog | 1.58000917 |
| 29 | MP0005379_endocrine/exocrine_gland_phen | 1.51121324 |
| 30 | MP0000685_abnormal_immune_system | 1.50619403 |
| 31 | MP0001905_abnormal_dopamine_level | 1.49252408 |
| 32 | MP0003186_abnormal_redox_activity | 1.45977589 |
| 33 | MP0003763_abnormal_thymus_physiology | 1.44461774 |
| 34 | MP0005645_abnormal_hypothalamus_physiol | 1.44411970 |
| 35 | MP0001800_abnormal_humoral_immune | 1.41188938 |
| 36 | MP0001984_abnormal_olfaction | 1.37510011 |
| 37 | MP0005075_abnormal_melanosome_morpholog | 1.37496188 |
| 38 | MP0003718_maternal_effect | 1.37300064 |
| 39 | MP0005253_abnormal_eye_physiology | 1.34578453 |
| 40 | MP0003195_calcinosis | 1.31478376 |
| 41 | MP0004142_abnormal_muscle_tone | 1.27791555 |
| 42 | MP0005000_abnormal_immune_tolerance | 1.21397759 |
| 43 | MP0002837_dystrophic_cardiac_calcinosis | 1.20992716 |
| 44 | MP0005389_reproductive_system_phenotype | 1.18848109 |
| 45 | MP0003950_abnormal_plasma_membrane | 1.18591996 |
| 46 | MP0004145_abnormal_muscle_electrophysio | 1.17150451 |
| 47 | MP0001501_abnormal_sleep_pattern | 1.17047168 |
| 48 | MP0001764_abnormal_homeostasis | 1.16568495 |
| 49 | MP0005410_abnormal_fertilization | 1.16204061 |
| 50 | MP0005387_immune_system_phenotype | 1.14092328 |
| 51 | MP0001790_abnormal_immune_system | 1.14092328 |
| 52 | MP0002138_abnormal_hepatobiliary_system | 1.13331091 |
| 53 | MP0002723_abnormal_immune_serum | 1.13088584 |
| 54 | MP0002933_joint_inflammation | 1.12877760 |
| 55 | MP0006276_abnormal_autonomic_nervous | 1.12020230 |
| 56 | MP0002420_abnormal_adaptive_immunity | 1.09819215 |
| 57 | MP0006054_spinal_hemorrhage | 1.09070987 |
| 58 | MP0003646_muscle_fatigue | 1.08874212 |
| 59 | MP0001819_abnormal_immune_cell | 1.08263992 |
| 60 | MP0002876_abnormal_thyroid_physiology | 1.07772872 |
| 61 | MP0003866_abnormal_defecation | 1.07436123 |
| 62 | MP0005167_abnormal_blood-brain_barrier | 1.06065091 |
| 63 | MP0002938_white_spotting | 1.05625115 |
| 64 | MP0003011_delayed_dark_adaptation | 1.05611143 |
| 65 | MP0008789_abnormal_olfactory_epithelium | 1.00531637 |
| 66 | MP0001919_abnormal_reproductive_system | 0.97942217 |
| 67 | MP0005025_abnormal_response_to | 0.96749922 |
| 68 | MP0002452_abnormal_antigen_presenting | 0.96017657 |
| 69 | MP0003252_abnormal_bile_duct | 0.95101545 |
| 70 | MP0002160_abnormal_reproductive_system | 0.94043092 |
| 71 | MP0002234_abnormal_pharynx_morphology | 0.93896243 |
| 72 | MP0005085_abnormal_gallbladder_physiolo | 0.92878830 |
| 73 | MP0001873_stomach_inflammation | 0.91299627 |
| 74 | MP0009764_decreased_sensitivity_to | 0.90932394 |
| 75 | MP0000689_abnormal_spleen_morphology | 0.90361962 |
| 76 | MP0000647_abnormal_sebaceous_gland | 0.90252117 |
| 77 | MP0002693_abnormal_pancreas_physiology | 0.90243243 |
| 78 | MP0008007_abnormal_cellular_replicative | 0.88217883 |
| 79 | MP0001293_anophthalmia | 0.88100150 |
| 80 | MP0001485_abnormal_pinna_reflex | 0.86250896 |
| 81 | MP0005636_abnormal_mineral_homeostasis | 0.85656662 |
| 82 | MP0000358_abnormal_cell_content/ | 0.84539382 |
| 83 | MP0008775_abnormal_heart_ventricle | 0.84364769 |
| 84 | MP0002277_abnormal_respiratory_mucosa | 0.84120766 |
| 85 | MP0002095_abnormal_skin_pigmentation | 0.84062056 |
| 86 | MP0009745_abnormal_behavioral_response | 0.82620954 |
| 87 | MP0003693_abnormal_embryo_hatching | 0.82491880 |
| 88 | MP0000716_abnormal_immune_system | 0.82341271 |
| 89 | MP0002398_abnormal_bone_marrow | 0.82140113 |
| 90 | MP0002132_abnormal_respiratory_system | 0.81906176 |
| 91 | MP0001986_abnormal_taste_sensitivity | 0.81227315 |
| 92 | MP0003567_abnormal_fetal_cardiomyocyte | 0.80993504 |
| 93 | MP0003787_abnormal_imprinting | 0.79281622 |
| 94 | MP0009046_muscle_twitch | 0.77526097 |
| 95 | MP0000427_abnormal_hair_cycle | 0.77123561 |
| 96 | MP0003137_abnormal_impulse_conducting | 0.75732856 |
| 97 | MP0002019_abnormal_tumor_incidence | 0.75388271 |
| 98 | MP0001845_abnormal_inflammatory_respons | 0.75315354 |
| 99 | MP0001119_abnormal_female_reproductive | 0.74778420 |
| 100 | MP0000703_abnormal_thymus_morphology | 0.74471917 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 4.80944525 |
| 2 | Mitochondrial inheritance (HP:0001427) | 4.55953145 |
| 3 | Hepatocellular necrosis (HP:0001404) | 4.37976708 |
| 4 | Abnormal mitochondria in muscle tissue (HP:0008316) | 4.36288520 |
| 5 | Increased CSF lactate (HP:0002490) | 4.22390893 |
| 6 | Acute encephalopathy (HP:0006846) | 4.11303037 |
| 7 | Progressive macrocephaly (HP:0004481) | 3.95786690 |
| 8 | Hepatic necrosis (HP:0002605) | 3.94138422 |
| 9 | IgG deficiency (HP:0004315) | 3.66576835 |
| 10 | Severe combined immunodeficiency (HP:0004430) | 3.38575369 |
| 11 | Pancreatic cysts (HP:0001737) | 3.35052954 |
| 12 | Increased hepatocellular lipid droplets (HP:0006565) | 3.34130737 |
| 13 | 3-Methylglutaconic aciduria (HP:0003535) | 3.22763421 |
| 14 | Increased serum lactate (HP:0002151) | 3.11900162 |
| 15 | Aplastic anemia (HP:0001915) | 3.10413419 |
| 16 | Hypoproteinemia (HP:0003075) | 3.09502957 |
| 17 | Lipid accumulation in hepatocytes (HP:0006561) | 3.09186614 |
| 18 | Type I transferrin isoform profile (HP:0003642) | 3.07295675 |
| 19 | Cerebral edema (HP:0002181) | 3.04649423 |
| 20 | Pancreatic fibrosis (HP:0100732) | 3.03965158 |
| 21 | B lymphocytopenia (HP:0010976) | 2.97729866 |
| 22 | True hermaphroditism (HP:0010459) | 2.93168232 |
| 23 | Abnormality of B cell number (HP:0010975) | 2.88566782 |
| 24 | Renal Fanconi syndrome (HP:0001994) | 2.75659260 |
| 25 | Thyroiditis (HP:0100646) | 2.71800254 |
| 26 | Lactic acidosis (HP:0003128) | 2.71308602 |
| 27 | T lymphocytopenia (HP:0005403) | 2.66823349 |
| 28 | Combined immunodeficiency (HP:0005387) | 2.65252364 |
| 29 | Pancytopenia (HP:0001876) | 2.62654446 |
| 30 | Optic disc pallor (HP:0000543) | 2.59849143 |
| 31 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.58666207 |
| 32 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.58666207 |
| 33 | Abnormal protein glycosylation (HP:0012346) | 2.58546688 |
| 34 | Abnormal glycosylation (HP:0012345) | 2.58546688 |
| 35 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.58546688 |
| 36 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.58546688 |
| 37 | Abnormality of the pons (HP:0007361) | 2.53144777 |
| 38 | Increased intramyocellular lipid droplets (HP:0012240) | 2.52602684 |
| 39 | Respiratory failure (HP:0002878) | 2.52124579 |
| 40 | Methylmalonic aciduria (HP:0012120) | 2.50730304 |
| 41 | Abnormality of midbrain morphology (HP:0002418) | 2.47383660 |
| 42 | Molar tooth sign on MRI (HP:0002419) | 2.47383660 |
| 43 | Congenital, generalized hypertrichosis (HP:0004540) | 2.45772174 |
| 44 | CNS demyelination (HP:0007305) | 2.43807337 |
| 45 | Abnormality of T cell number (HP:0011839) | 2.40286881 |
| 46 | Abolished electroretinogram (ERG) (HP:0000550) | 2.39947457 |
| 47 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 2.37315976 |
| 48 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.35817410 |
| 49 | Exercise intolerance (HP:0003546) | 2.31534897 |
| 50 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.30556237 |
| 51 | Aplasia/hypoplasia of the uterus (HP:0008684) | 2.28166776 |
| 52 | Type II lissencephaly (HP:0007260) | 2.28073416 |
| 53 | Increased IgM level (HP:0003496) | 2.27507072 |
| 54 | Oral leukoplakia (HP:0002745) | 2.27168964 |
| 55 | Renal cortical cysts (HP:0000803) | 2.26859532 |
| 56 | Hypoplasia of the pons (HP:0012110) | 2.24267718 |
| 57 | Abnormality of T cells (HP:0002843) | 2.23025310 |
| 58 | Stomatitis (HP:0010280) | 2.22906248 |
| 59 | Abnormality of the renal cortex (HP:0011035) | 2.21564326 |
| 60 | Lethargy (HP:0001254) | 2.21179927 |
| 61 | Methylmalonic acidemia (HP:0002912) | 2.20873988 |
| 62 | Nephronophthisis (HP:0000090) | 2.20512730 |
| 63 | Abnormality of eosinophils (HP:0001879) | 2.17111037 |
| 64 | Elevated erythrocyte sedimentation rate (HP:0003565) | 2.16563984 |
| 65 | Abnormality of alanine metabolism (HP:0010916) | 2.14346664 |
| 66 | Hyperalaninemia (HP:0003348) | 2.14346664 |
| 67 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.14346664 |
| 68 | Exertional dyspnea (HP:0002875) | 2.12978438 |
| 69 | Congenital stationary night blindness (HP:0007642) | 2.10180563 |
| 70 | Increased muscle lipid content (HP:0009058) | 2.06749293 |
| 71 | Leukodystrophy (HP:0002415) | 2.05972475 |
| 72 | Pendular nystagmus (HP:0012043) | 2.02236909 |
| 73 | Sclerocornea (HP:0000647) | 2.01262765 |
| 74 | Abnormality of the renal collecting system (HP:0004742) | 2.01014693 |
| 75 | Progressive microcephaly (HP:0000253) | 1.99864160 |
| 76 | Duplicated collecting system (HP:0000081) | 1.97669339 |
| 77 | Eosinophilia (HP:0001880) | 1.96749266 |
| 78 | Hypoplasia of the thymus (HP:0000778) | 1.95806408 |
| 79 | Cerebral hypomyelination (HP:0006808) | 1.93816613 |
| 80 | Medial flaring of the eyebrow (HP:0010747) | 1.93080595 |
| 81 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 1.92775849 |
| 82 | Dicarboxylic aciduria (HP:0003215) | 1.92775849 |
| 83 | Emotional lability (HP:0000712) | 1.92320089 |
| 84 | Attenuation of retinal blood vessels (HP:0007843) | 1.90341994 |
| 85 | Panhypogammaglobulinemia (HP:0003139) | 1.87660396 |
| 86 | Cellular immunodeficiency (HP:0005374) | 1.81864303 |
| 87 | Large for gestational age (HP:0001520) | 1.81721444 |
| 88 | Retinal dysplasia (HP:0007973) | 1.79525211 |
| 89 | IgM deficiency (HP:0002850) | 1.78594818 |
| 90 | Generalized aminoaciduria (HP:0002909) | 1.76751890 |
| 91 | Reduced antithrombin III activity (HP:0001976) | 1.74094536 |
| 92 | Erythroderma (HP:0001019) | 1.73105692 |
| 93 | Aplasia/Hypoplasia of the tongue (HP:0010295) | 1.72593038 |
| 94 | Hypoplasia of the uterus (HP:0000013) | 1.72365841 |
| 95 | Constricted visual fields (HP:0001133) | 1.71680075 |
| 96 | Opisthotonus (HP:0002179) | 1.70862685 |
| 97 | Cerebral palsy (HP:0100021) | 1.70430075 |
| 98 | Postaxial foot polydactyly (HP:0001830) | 1.70273750 |
| 99 | Colon cancer (HP:0003003) | 1.69944214 |
| 100 | Abnormality of the renal medulla (HP:0100957) | 1.69681431 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | VRK2 | 4.28692580 |
| 2 | TXK | 3.91746746 |
| 3 | TESK2 | 3.07742802 |
| 4 | ZAK | 3.04507888 |
| 5 | TLK1 | 2.95609586 |
| 6 | BUB1 | 2.93791530 |
| 7 | BCKDK | 2.81921860 |
| 8 | KDR | 2.60810400 |
| 9 | VRK1 | 2.51655039 |
| 10 | MST4 | 2.39700001 |
| 11 | TESK1 | 2.37146264 |
| 12 | LIMK1 | 2.18273026 |
| 13 | NUAK1 | 2.10160626 |
| 14 | MAP4K2 | 2.09034129 |
| 15 | NEK1 | 1.76079329 |
| 16 | TRIM28 | 1.73690456 |
| 17 | EIF2AK3 | 1.71291555 |
| 18 | FRK | 1.69319545 |
| 19 | MAP3K12 | 1.62233806 |
| 20 | DAPK1 | 1.58066179 |
| 21 | ADRBK2 | 1.57614235 |
| 22 | SRPK1 | 1.53890050 |
| 23 | STK16 | 1.50742128 |
| 24 | GRK1 | 1.48036504 |
| 25 | EIF2AK1 | 1.40221262 |
| 26 | BMPR1B | 1.37926613 |
| 27 | TAOK3 | 1.37330141 |
| 28 | CSNK1G3 | 1.31526939 |
| 29 | TSSK6 | 1.30372070 |
| 30 | WNK4 | 1.19890162 |
| 31 | PLK3 | 1.16225985 |
| 32 | CSNK1G1 | 1.07887310 |
| 33 | CSNK1G2 | 1.06923241 |
| 34 | NME1 | 1.06172198 |
| 35 | TAF1 | 1.04364253 |
| 36 | GRK7 | 1.03623292 |
| 37 | CSNK1A1L | 1.02923267 |
| 38 | CAMKK2 | 1.02575858 |
| 39 | TIE1 | 1.02101901 |
| 40 | MAPKAPK3 | 0.99032315 |
| 41 | PDK2 | 0.98579496 |
| 42 | ITK | 0.94268137 |
| 43 | WNK3 | 0.90106188 |
| 44 | EIF2AK2 | 0.89885549 |
| 45 | MAP4K1 | 0.87180993 |
| 46 | RPS6KA4 | 0.85384189 |
| 47 | DYRK2 | 0.80834473 |
| 48 | PIK3CG | 0.80766925 |
| 49 | GRK5 | 0.78784442 |
| 50 | PLK2 | 0.77193302 |
| 51 | PINK1 | 0.76531227 |
| 52 | INSRR | 0.75629592 |
| 53 | SCYL2 | 0.72817077 |
| 54 | STK39 | 0.70666052 |
| 55 | PBK | 0.70445333 |
| 56 | CDK19 | 0.69753754 |
| 57 | IKBKE | 0.69143027 |
| 58 | PHKG2 | 0.68738927 |
| 59 | PHKG1 | 0.68738927 |
| 60 | OXSR1 | 0.66166532 |
| 61 | AURKA | 0.65300139 |
| 62 | MAP2K6 | 0.64938330 |
| 63 | MYLK | 0.64874838 |
| 64 | RPS6KA5 | 0.64581329 |
| 65 | CDC7 | 0.62852428 |
| 66 | PRKCQ | 0.60446347 |
| 67 | IKBKB | 0.59635200 |
| 68 | LMTK2 | 0.55900691 |
| 69 | MAP2K7 | 0.55321181 |
| 70 | BCR | 0.54406324 |
| 71 | PLK1 | 0.53055896 |
| 72 | ADRBK1 | 0.52076237 |
| 73 | AURKB | 0.50769750 |
| 74 | SYK | 0.45889557 |
| 75 | MAPK13 | 0.43759663 |
| 76 | STK10 | 0.43371868 |
| 77 | LCK | 0.43213389 |
| 78 | ERBB3 | 0.42086654 |
| 79 | DAPK2 | 0.41849443 |
| 80 | ATR | 0.41577942 |
| 81 | CSNK2A1 | 0.39236587 |
| 82 | KIT | 0.39087020 |
| 83 | CSNK1A1 | 0.38071841 |
| 84 | FES | 0.37116582 |
| 85 | TEC | 0.35538092 |
| 86 | DAPK3 | 0.34115044 |
| 87 | PRKCG | 0.32746318 |
| 88 | WEE1 | 0.31575692 |
| 89 | NME2 | 0.31263004 |
| 90 | CSNK2A2 | 0.31072386 |
| 91 | PAK3 | 0.29966666 |
| 92 | PLK4 | 0.29083846 |
| 93 | LYN | 0.28809832 |
| 94 | PTK2B | 0.28354209 |
| 95 | OBSCN | 0.28341186 |
| 96 | IGF1R | 0.28180370 |
| 97 | TBK1 | 0.27780105 |
| 98 | MINK1 | 0.27560554 |
| 99 | PRKCE | 0.26997038 |
| 100 | PAK1 | 0.26236318 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 5.14405082 |
| 2 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.55585800 |
| 3 | Parkinsons disease_Homo sapiens_hsa05012 | 2.95166329 |
| 4 | RNA polymerase_Homo sapiens_hsa03020 | 2.92563836 |
| 5 | Protein export_Homo sapiens_hsa03060 | 2.78377564 |
| 6 | Primary immunodeficiency_Homo sapiens_hsa05340 | 2.38252059 |
| 7 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 2.19981323 |
| 8 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 2.10560809 |
| 9 | DNA replication_Homo sapiens_hsa03030 | 2.05730629 |
| 10 | Huntingtons disease_Homo sapiens_hsa05016 | 2.01189533 |
| 11 | Alzheimers disease_Homo sapiens_hsa05010 | 1.96702556 |
| 12 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.89008391 |
| 13 | Ribosome_Homo sapiens_hsa03010 | 1.88731901 |
| 14 | Homologous recombination_Homo sapiens_hsa03440 | 1.88041576 |
| 15 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.80215520 |
| 16 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.77496091 |
| 17 | Mismatch repair_Homo sapiens_hsa03430 | 1.72135193 |
| 18 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.64299972 |
| 19 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.55756776 |
| 20 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.53209138 |
| 21 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.51783569 |
| 22 | Base excision repair_Homo sapiens_hsa03410 | 1.47188558 |
| 23 | RNA degradation_Homo sapiens_hsa03018 | 1.45159044 |
| 24 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.44263777 |
| 25 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.38866318 |
| 26 | Basal transcription factors_Homo sapiens_hsa03022 | 1.33119021 |
| 27 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.31169312 |
| 28 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.30079924 |
| 29 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.28386039 |
| 30 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.22353252 |
| 31 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.21582432 |
| 32 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.21066406 |
| 33 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.20923998 |
| 34 | Peroxisome_Homo sapiens_hsa04146 | 1.19221802 |
| 35 | Spliceosome_Homo sapiens_hsa03040 | 1.16125481 |
| 36 | Purine metabolism_Homo sapiens_hsa00230 | 1.16037132 |
| 37 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.15853020 |
| 38 | Allograft rejection_Homo sapiens_hsa05330 | 1.15743317 |
| 39 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.12839266 |
| 40 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.11522887 |
| 41 | Phototransduction_Homo sapiens_hsa04744 | 1.10668411 |
| 42 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.09622076 |
| 43 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.06936145 |
| 44 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.03511891 |
| 45 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.01761755 |
| 46 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.00870625 |
| 47 | RNA transport_Homo sapiens_hsa03013 | 1.00130609 |
| 48 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.98825386 |
| 49 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.95076309 |
| 50 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.93477667 |
| 51 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.89050066 |
| 52 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.87458758 |
| 53 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.85519166 |
| 54 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.84214990 |
| 55 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.83362332 |
| 56 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.83334601 |
| 57 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.80270164 |
| 58 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.79622341 |
| 59 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.78369620 |
| 60 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.77799178 |
| 61 | Metabolic pathways_Homo sapiens_hsa01100 | 0.77541726 |
| 62 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.77366824 |
| 63 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.76690975 |
| 64 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.76070977 |
| 65 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.74734187 |
| 66 | Asthma_Homo sapiens_hsa05310 | 0.73799219 |
| 67 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.70362694 |
| 68 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.69214760 |
| 69 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.68440936 |
| 70 | Carbon metabolism_Homo sapiens_hsa01200 | 0.67552572 |
| 71 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.62357984 |
| 72 | Sulfur relay system_Homo sapiens_hsa04122 | 0.62200653 |
| 73 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.61145850 |
| 74 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.60817212 |
| 75 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.59880237 |
| 76 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.57311307 |
| 77 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.55867055 |
| 78 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.55508880 |
| 79 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.55452516 |
| 80 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.55093147 |
| 81 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.53500839 |
| 82 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.51993756 |
| 83 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.50500814 |
| 84 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.49682211 |
| 85 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.49508610 |
| 86 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.48091576 |
| 87 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.47380563 |
| 88 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.46344954 |
| 89 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.43678911 |
| 90 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.43677987 |
| 91 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.43620435 |
| 92 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.42953997 |
| 93 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.42721454 |
| 94 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.42417001 |
| 95 | Retinol metabolism_Homo sapiens_hsa00830 | 0.39817410 |
| 96 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.39238856 |
| 97 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.37718814 |
| 98 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.37048029 |
| 99 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.34973681 |
| 100 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.32952957 |

