ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	eosinophil chemotaxis (GO:0048245)	9.61872507
2	negative regulation of Ras GTPase activity (GO:0034261)	9.42118159
3	eosinophil migration (GO:0072677)	8.69499229
4	negative regulation of T cell receptor signaling pathway (GO:0050860)	8.59749537
5	fucose catabolic process (GO:0019317)	8.01848484
6	L-fucose metabolic process (GO:0042354)	8.01848484
7	L-fucose catabolic process (GO:0042355)	8.01848484
8	ribosomal small subunit assembly (GO:0000028)	7.90103596
9	regulation of sister chromatid cohesion (GO:0007063)	7.79741276
10	regulation of mononuclear cell migration (GO:0071675)	7.66240847
11	negative regulation of peptidyl-threonine phosphorylation (GO:0010801)	7.35314949
12	negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)	6.78265901
13	branch elongation of an epithelium (GO:0060602)	6.75982822
14	positive regulation of chromosome segregation (GO:0051984)	6.62262936
15	vesicle fusion (GO:0006906)	6.40974925
16	negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)	6.40572567
17	autophagic vacuole fusion (GO:0000046)	5.83900199
18	regulation of T cell receptor signaling pathway (GO:0050856)	5.54847174
19	macrophage chemotaxis (GO:0048246)	5.50872406
20	coenzyme A biosynthetic process (GO:0015937)	5.48473477
21	seminiferous tubule development (GO:0072520)	5.28105127
22	organ growth (GO:0035265)	5.22451999
23	peptidyl-lysine dimethylation (GO:0018027)	5.18059009
24	positive regulation of calcium ion import (GO:0090280)	5.05221219
25	proteasome assembly (GO:0043248)	4.91389393
26	monocyte chemotaxis (GO:0002548)	4.84138302
27	establishment of mitotic spindle orientation (GO:0000132)	4.80775703
28	protein import into peroxisome matrix (GO:0016558)	4.74678592
29	localization within membrane (GO:0051668)	4.71804284
30	axis elongation (GO:0003401)	4.58840427
31	organelle membrane fusion (GO:0090174)	4.52634032
32	oxidative demethylation (GO:0070989)	4.40957578
33	fucose metabolic process (GO:0006004)	4.40820863
34	double-strand break repair via nonhomologous end joining (GO:0006303)	4.40262721
35	non-recombinational repair (GO:0000726)	4.40262721
36	fucosylation (GO:0036065)	4.39609980
37	negative regulation of GTPase activity (GO:0034260)	4.27036942
38	negative regulation of GTP catabolic process (GO:0033125)	4.27036942
39	establishment of mitotic spindle localization (GO:0040001)	4.26341221
40	regulation of nitric-oxide synthase biosynthetic process (GO:0051769)	4.24456195
41	membrane budding (GO:0006900)	4.20366755
42	regulation of beta-amyloid formation (GO:1902003)	4.13778910
43	detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)	4.13338909
44	regulation of antigen receptor-mediated signaling pathway (GO:0050854)	4.07592125
45	negative regulation of circadian rhythm (GO:0042754)	3.96165458
46	establishment of spindle orientation (GO:0051294)	3.93989776
47	organelle fusion (GO:0048284)	3.89081700
48	DNA demethylation (GO:0080111)	3.77029812
49	positive chemotaxis (GO:0050918)	3.72082825
50	preassembly of GPI anchor in ER membrane (GO:0016254)	3.71637081
51	histone H3-K9 methylation (GO:0051567)	3.71316962
52	acrosome assembly (GO:0001675)	3.70190943
53	pantothenate metabolic process (GO:0015939)	3.68518376
54	metallo-sulfur cluster assembly (GO:0031163)	3.66192256
55	iron-sulfur cluster assembly (GO:0016226)	3.66192256
56	purine nucleoside bisphosphate biosynthetic process (GO:0034033)	3.60891347
57	ribonucleoside bisphosphate biosynthetic process (GO:0034030)	3.60891347
58	nucleoside bisphosphate biosynthetic process (GO:0033866)	3.60891347
59	detection of chemical stimulus involved in sensory perception of taste (GO:0050912)	3.57825696
60	signal peptide processing (GO:0006465)	3.36709802
61	regulation of autophagic vacuole assembly (GO:2000785)	3.33633952
62	cardiolipin metabolic process (GO:0032048)	3.28922560
63	single-organism membrane fusion (GO:0044801)	3.27851069
64	protein localization to peroxisome (GO:0072662)	3.23154504
65	protein targeting to peroxisome (GO:0006625)	3.23154504
66	establishment of protein localization to peroxisome (GO:0072663)	3.23154504
67	RNA methylation (GO:0001510)	3.19114357
68	regulation of fibroblast growth factor receptor signaling pathway (GO:0040036)	3.15761616
69	regulation of amyloid precursor protein catabolic process (GO:1902991)	3.11200695
70	negative regulation of macroautophagy (GO:0016242)	3.10341293
71	establishment of protein localization to vacuole (GO:0072666)	3.10191072
72	protein targeting to vacuole (GO:0006623)	3.10191072
73	protein targeting to lysosome (GO:0006622)	3.10191072
74	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	3.09480654
75	mitochondrial RNA metabolic process (GO:0000959)	3.09291773
76	coenzyme A metabolic process (GO:0015936)	3.08486109
77	DNA deamination (GO:0045006)	3.06791219
78	ER to Golgi vesicle-mediated transport (GO:0006888)	3.06232923
79	3-UTR-mediated mRNA stabilization (GO:0070935)	3.02373815
80	DNA dealkylation (GO:0035510)	2.95192938
81	regulation of stem cell maintenance (GO:2000036)	2.93023388
82	peroxisomal transport (GO:0043574)	2.92755495
83	DNA integration (GO:0015074)	2.91209312
84	intracellular protein transmembrane import (GO:0044743)	2.85875791
85	telomere maintenance via recombination (GO:0000722)	2.85813132
86	regulation of calcium ion import (GO:0090279)	2.83378795
87	regulation of mammary gland epithelial cell proliferation (GO:0033599)	2.81195008
88	histone H3-K9 modification (GO:0061647)	2.80567102
89	regulation of T cell apoptotic process (GO:0070232)	2.80145856
90	sodium-independent organic anion transport (GO:0043252)	2.79530685
91	positive regulation of interleukin-1 beta secretion (GO:0050718)	2.79396365
92	imidazole-containing compound metabolic process (GO:0052803)	2.79162269
93	negative regulation of purine nucleotide catabolic process (GO:0033122)	2.78698617
94	establishment of spindle localization (GO:0051293)	2.77670116
95	cytidine catabolic process (GO:0006216)	2.74100839
96	protein prenylation (GO:0018342)	12.6686532
97	prenylation (GO:0097354)	12.6686532
98	positive regulation of mitotic sister chromatid separation (GO:1901970)	10.2500132
99	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	10.2500132
100	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	10.2500132

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GATA1_22025678_ChIP-Seq_K562_Human	8.48156305
2	VDR_22108803_ChIP-Seq_LS180_Human	6.21505803
3	NOTCH1_21737748_ChIP-Seq_TLL_Human	3.58193683
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.44534473
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.18793630
6	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.01776456
7	AR_21572438_ChIP-Seq_LNCaP_Human	2.90703388
8	YY1_21170310_ChIP-Seq_MESCs_Mouse	2.85477971
9	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.69295134
10	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.60395028
11	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.54657829
12	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.13656253
13	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.11939339
14	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	2.07401170
15	ZNF263_19887448_ChIP-Seq_K562_Human	2.03402732
16	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	10.2998970
17	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.97354111
18	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.96655582
19	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.94910661
20	ZNF274_21170338_ChIP-Seq_K562_Hela	1.92182846
21	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.90462500
22	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.82081496
23	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.80146920
24	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.75356723
25	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.68619159
26	ZIC3_20872845_ChIP-ChIP_MESCs_Mouse	1.66887316
27	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.64302573
28	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.54928569
29	VDR_23849224_ChIP-Seq_CD4+_Human	1.41981727
30	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.41741254
31	BCAT_22108803_ChIP-Seq_LS180_Human	1.38684094
32	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.25971605
33	RXR_22108803_ChIP-Seq_LS180_Human	1.22775575
34	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.19486541
35	GATA3_26560356_Chip-Seq_TH1_Human	1.18048435
36	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.16340927
37	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.16340927
38	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.16147275
39	IRF1_19129219_ChIP-ChIP_H3396_Human	1.15062605
40	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.11013011
41	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.09863381
42	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.07908508
43	TP53_22573176_ChIP-Seq_HFKS_Human	1.07426737
44	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.04529970
45	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.03961989
46	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.01879855
47	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.01879855
48	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.01784311
49	FOXP3_21729870_ChIP-Seq_TREG_Human	1.00196473
50	RUNX_20019798_ChIP-Seq_JUKART_Human	0.98116073
51	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.95839687
52	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.93173665
53	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.92951669
54	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.91814875
55	NANOG_20526341_ChIP-Seq_ESCs_Human	0.90559218
56	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.90512189
57	MYC_18358816_ChIP-ChIP_MESCs_Mouse	0.89550063
58	NANOG_19829295_ChIP-Seq_ESCs_Human	0.87750487
59	SOX2_19829295_ChIP-Seq_ESCs_Human	0.87750487
60	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.85370890
61	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.84835164
62	CREB1_15753290_ChIP-ChIP_HEK293T_Human	0.84067398
63	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	0.83244212
64	FUS_26573619_Chip-Seq_HEK293_Human	0.82816692
65	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	0.81965014
66	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.81930860
67	ELK1_19687146_ChIP-ChIP_HELA_Human	0.81340540
68	TCF4_22108803_ChIP-Seq_LS180_Human	0.79982815
69	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.79537044
70	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.78378906
71	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.78238249
72	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.78036129
73	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.75906856
74	EZH2_22144423_ChIP-Seq_EOC_Human	0.74725370
75	ERG_20517297_ChIP-Seq_VCAP_Human	0.74393231
76	GABP_19822575_ChIP-Seq_HepG2_Human	0.74129615
77	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.73265528
78	AR_20517297_ChIP-Seq_VCAP_Human	0.72827458
79	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.71437393
80	STAT1_20625510_ChIP-Seq_HELA_Human	0.70641453
81	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.69716512
82	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	0.68775713
83	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	0.68775713
84	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	0.68775713
85	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	0.67946992
86	TAF15_26573619_Chip-Seq_HEK293_Human	0.67904544
87	SOX3_22085726_ChIP-Seq_MUSCLE_Mouse	0.67850956
88	NANOG_18358816_ChIP-ChIP_MESCs_Mouse	0.67134318
89	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.67033152
90	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.66284448
91	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.65892723
92	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	0.65758178
93	P300_19829295_ChIP-Seq_ESCs_Human	0.65577982
94	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.65308925
95	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	0.63845001
96	BCL6_27268052_Chip-Seq_Bcells_Human	0.63801759
97	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.63584341
98	P53_21459846_ChIP-Seq_SAOS-2_Human	0.61540333
99	WDR5_24793694_ChIP-Seq_LNCAP_Human	0.60576112
100	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.60479336

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003303_peritoneal_inflammation	8.09597246
2	MP0006082_CNS_inflammation	4.87961343
3	MP0001663_abnormal_digestive_system	3.25853016
4	MP0001664_abnormal_digestion	2.93614066
5	MP0001919_abnormal_reproductive_system	2.73797400
6	MP0009379_abnormal_foot_pigmentation	2.64211786
7	MP0000467_abnormal_esophagus_morphology	2.64148738
8	MP0005381_digestive/alimentary_phenotyp	2.49398089
9	MP0002751_abnormal_autonomic_nervous	2.42008067
10	MP0001545_abnormal_hematopoietic_system	2.11545401
11	MP0005397_hematopoietic_system_phenotyp	2.11545401
12	MP0000566_synostosis	10.9634061
13	MP0005389_reproductive_system_phenotype	1.90756645
14	MP0000383_abnormal_hair_follicle	1.88749113
15	MP0002876_abnormal_thyroid_physiology	1.75535780
16	MP0003115_abnormal_respiratory_system	1.74753477
17	MP0005166_decreased_susceptibility_to	1.73646705
18	MP0008058_abnormal_DNA_repair	1.67314836
19	MP0005645_abnormal_hypothalamus_physiol	1.67014769
20	MP0000534_abnormal_ureter_morphology	1.54215709
21	MP0005671_abnormal_response_to	1.46890194
22	MP0004145_abnormal_muscle_electrophysio	1.34432397
23	MP0003646_muscle_fatigue	1.34360723
24	MP0005360_urolithiasis	1.32162775
25	MP0000490_abnormal_crypts_of	1.31324607
26	MP0003937_abnormal_limbs/digits/tail_de	1.19402913
27	MP0010155_abnormal_intestine_physiology	1.19376652
28	MP0001293_anophthalmia	1.15292963
29	MP0001764_abnormal_homeostasis	1.12569883
30	MP0003195_calcinosis	1.10272661
31	MP0010678_abnormal_skin_adnexa	1.09563256
32	MP0003763_abnormal_thymus_physiology	1.08723979
33	MP0001915_intracranial_hemorrhage	1.00393627
34	MP0001286_abnormal_eye_development	0.99990105
35	MP0002822_catalepsy	0.99574494
36	MP0001873_stomach_inflammation	0.97630351
37	MP0008872_abnormal_physiological_respon	0.90497523
38	MP0003011_delayed_dark_adaptation	0.89828097
39	MP0003878_abnormal_ear_physiology	0.88915902
40	MP0005377_hearing/vestibular/ear_phenot	0.88915902
41	MP0005501_abnormal_skin_physiology	0.86296902
42	MP0002019_abnormal_tumor_incidence	0.83891892
43	MP0001986_abnormal_taste_sensitivity	0.82555802
44	MP0005551_abnormal_eye_electrophysiolog	0.80621357
45	MP0000477_abnormal_intestine_morphology	0.80321984
46	MP0002405_respiratory_system_inflammati	0.79424720
47	MP0002102_abnormal_ear_morphology	0.79206439
48	MP0006292_abnormal_olfactory_placode	0.78947864
49	MP0002736_abnormal_nociception_after	0.77901290
50	MP0001968_abnormal_touch/_nociception	0.75278365
51	MP0009785_altered_susceptibility_to	0.74154740
52	MP0003453_abnormal_keratinocyte_physiol	0.73725586
53	MP0002109_abnormal_limb_morphology	0.73159779
54	MP0000372_irregular_coat_pigmentation	0.72970175
55	MP0008875_abnormal_xenobiotic_pharmacok	0.72297044
56	MP0000428_abnormal_craniofacial_morphol	0.71940599
57	MP0000470_abnormal_stomach_morphology	0.71734783
58	MP0001835_abnormal_antigen_presentation	0.71633501
59	MP0002210_abnormal_sex_determination	0.71270573
60	MP0002234_abnormal_pharynx_morphology	0.71124053
61	MP0001790_abnormal_immune_system	0.70380468
62	MP0005387_immune_system_phenotype	0.70380468
63	MP0005085_abnormal_gallbladder_physiolo	0.70128504
64	MP0005253_abnormal_eye_physiology	0.69284314
65	MP0004019_abnormal_vitamin_homeostasis	0.67089112
66	MP0000026_abnormal_inner_ear	0.65567954
67	MP0002115_abnormal_skeleton_extremities	0.65180966
68	MP0000358_abnormal_cell_content/	0.65163810
69	MP0001963_abnormal_hearing_physiology	0.64427642
70	MP0005025_abnormal_response_to	0.64284597
71	MP0001800_abnormal_humoral_immune	0.61035053
72	MP0005332_abnormal_amino_acid	0.60865336
73	MP0009763_increased_sensitivity_to	0.60166282
74	MP0003942_abnormal_urinary_system	0.58838049
75	MP0009333_abnormal_splenocyte_physiolog	0.58022159
76	MP0003136_yellow_coat_color	0.56543328
77	MP0003936_abnormal_reproductive_system	0.56273664
78	MP0002168_other_aberrant_phenotype	0.55549295
79	MP0001666_abnormal_nutrient_absorption	0.52384269
80	MP0002837_dystrophic_cardiac_calcinosis	0.52045026
81	MP0002184_abnormal_innervation	0.51799189
82	MP0005379_endocrine/exocrine_gland_phen	0.51404923
83	MP0002277_abnormal_respiratory_mucosa	0.50704413
84	MP0003718_maternal_effect	0.48648256
85	MP0002735_abnormal_chemical_nociception	0.47928904
86	MP0002163_abnormal_gland_morphology	0.47843659
87	MP0003283_abnormal_digestive_organ	0.47547060
88	MP0000858_altered_metastatic_potential	0.46886603
89	MP0002452_abnormal_antigen_presenting	0.46711455
90	MP0003448_altered_tumor_morphology	0.46520164
91	MP0009672_abnormal_birth_weight	0.45783454
92	MP0005000_abnormal_immune_tolerance	0.45560310
93	MP0006072_abnormal_retinal_apoptosis	0.45321709
94	MP0005084_abnormal_gallbladder_morpholo	0.44832276
95	MP0006276_abnormal_autonomic_nervous	0.44596267
96	MP0005395_other_phenotype	0.44503306
97	MP0004782_abnormal_surfactant_physiolog	0.43869862
98	MP0003866_abnormal_defecation	0.43762175
99	MP0000538_abnormal_urinary_bladder	0.43418713
100	MP0002139_abnormal_hepatobiliary_system	0.42693275

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	9.01595641
2	Duplicated collecting system (HP:0000081)	7.97626596
3	Abnormality of the renal collecting system (HP:0004742)	7.35009014
4	Long foot (HP:0001833)	6.39377698
5	Large for gestational age (HP:0001520)	6.18321739
6	Abnormality of fatty-acid metabolism (HP:0004359)	6.06155414
7	Adactyly (HP:0009776)	5.46129425
8	Acute lymphatic leukemia (HP:0006721)	4.80984617
9	Dry hair (HP:0011359)	4.70089355
10	Hypoplastic pelvis (HP:0008839)	4.68146307
11	Absent rod-and cone-mediated responses on ERG (HP:0007688)	4.29191687
12	Menstrual irregularities (HP:0000858)	4.25660446
13	Progressive muscle weakness (HP:0003323)	4.16255123
14	Brushfield spots (HP:0001088)	4.13531011
15	Ureteral duplication (HP:0000073)	4.07868789
16	Pendular nystagmus (HP:0012043)	4.01203781
17	Ureteral stenosis (HP:0000071)	3.97657610
18	Autoamputation (HP:0001218)	3.75209317
19	Steatorrhea (HP:0002570)	3.74536809
20	Severe muscular hypotonia (HP:0006829)	3.65773123
21	Pulmonary artery stenosis (HP:0004415)	3.65383810
22	Ureteral obstruction (HP:0006000)	3.65086980
23	Broad-based gait (HP:0002136)	3.47560943
24	Reduced subcutaneous adipose tissue (HP:0003758)	3.44783763
25	Hypoplastic nipples (HP:0002557)	3.39529708
26	Abnormal auditory evoked potentials (HP:0006958)	3.20588011
27	Decreased muscle mass (HP:0003199)	3.13042377
28	Abnormal rod and cone electroretinograms (HP:0008323)	3.09885298
29	Decreased central vision (HP:0007663)	3.02947392
30	Anhidrosis (HP:0000970)	2.95964523
31	Fat malabsorption (HP:0002630)	2.92269564
32	Sudden death (HP:0001699)	2.89971310
33	Palmoplantar hyperkeratosis (HP:0000972)	2.86380700
34	Abnormal ventriculo-arterial connection (HP:0011563)	2.80227430
35	Transposition of the great arteries (HP:0001669)	2.80227430
36	Abnormal connection of the cardiac segments (HP:0011545)	2.80227430
37	Decreased lacrimation (HP:0000633)	2.80041305
38	Palmar hyperkeratosis (HP:0010765)	2.70178742
39	Polyneuropathy (HP:0001271)	2.70062631
40	Clubbing of toes (HP:0100760)	2.65977306
41	Acanthocytosis (HP:0001927)	2.53816876
42	Anxiety (HP:0000739)	2.51260605
43	Lactic acidosis (HP:0003128)	2.49445589
44	Abnormality of vision evoked potentials (HP:0000649)	2.45712579
45	Increased number of teeth (HP:0011069)	2.41962433
46	Increased corneal curvature (HP:0100692)	2.39287607
47	Keratoconus (HP:0000563)	2.39287607
48	Hypoplastic iliac wings (HP:0002866)	2.33720330
49	Attenuation of retinal blood vessels (HP:0007843)	2.30512290
50	Acute necrotizing encephalopathy (HP:0006965)	2.27323101
51	Plantar hyperkeratosis (HP:0007556)	2.26748511
52	Myoglobinuria (HP:0002913)	2.21978306
53	Polymicrogyria (HP:0002126)	2.21074469
54	Epiphyseal stippling (HP:0010655)	2.19540785
55	Congenital stationary night blindness (HP:0007642)	2.14363037
56	Rhabdomyolysis (HP:0003201)	2.12363014
57	Cerebral hypomyelination (HP:0006808)	2.12139533
58	Broad nasal tip (HP:0000455)	2.11021955
59	Chorioretinal coloboma (HP:0000567)	2.08998286
60	Wide intermamillary distance (HP:0006610)	2.06130619
61	Postnatal microcephaly (HP:0005484)	2.02187831
62	Generalized amyotrophy (HP:0003700)	1.96786074
63	Mitochondrial inheritance (HP:0001427)	1.94824634
64	Thickened calvaria (HP:0002684)	1.94088373
65	CNS demyelination (HP:0007305)	1.93181654
66	Metabolic acidosis (HP:0001942)	1.91026111
67	Abnormal mitochondria in muscle tissue (HP:0008316)	1.89544890
68	Female pseudohermaphroditism (HP:0010458)	1.86122015
69	Progressive macrocephaly (HP:0004481)	1.84279957
70	Purpura (HP:0000979)	1.83300496
71	Abnormal epiphyseal ossification (HP:0010656)	1.82831956
72	Acute encephalopathy (HP:0006846)	1.82755134
73	Widely spaced teeth (HP:0000687)	1.82317096
74	Spastic tetraplegia (HP:0002510)	1.82224570
75	Elevated erythrocyte sedimentation rate (HP:0003565)	1.80951566
76	Basal ganglia calcification (HP:0002135)	1.80331354
77	Large hands (HP:0001176)	1.76813830
78	IgG deficiency (HP:0004315)	1.76477680
79	Exercise intolerance (HP:0003546)	1.74897274
80	Increased serum lactate (HP:0002151)	1.73981737
81	Respiratory failure (HP:0002878)	1.70675767
82	Prenatal maternal abnormality (HP:0002686)	1.69672611
83	Increased CSF lactate (HP:0002490)	1.69492752
84	Flat face (HP:0012368)	1.67823790
85	Aplasia/Hypoplasia of the nipples (HP:0006709)	1.63818245
86	Overfolded helix (HP:0000396)	1.60706632
87	Congenital onset (HP:0003577)	1.59861223
88	Stomatitis (HP:0010280)	1.58910145
89	Gangrene (HP:0100758)	1.57995053
90	Optic disc pallor (HP:0000543)	1.57914014
91	Acute hepatic failure (HP:0006554)	1.57561807
92	3-Methylglutaconic aciduria (HP:0003535)	1.56586179
93	Abnormality of the basal ganglia (HP:0002134)	1.54095923
94	Abnormality of the line of Schwalbe (HP:0008048)	1.53626946
95	Self-mutilation (HP:0000742)	1.52767942
96	Posterior embryotoxon (HP:0000627)	1.51500922
97	Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)	1.49460561
98	External ear malformation (HP:0008572)	1.48512337
99	Alkalosis (HP:0001948)	1.47907758
100	Primary adrenal insufficiency (HP:0008207)	1.47882007

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MKNK1	6.63252044
2	TAOK2	5.21758457
3	TAOK1	4.95823878
4	MAP3K11	3.96554163
5	MAP3K3	3.72800548
6	MAP2K3	3.49636165
7	JAK3	2.27456620
8	MKNK2	11.1105010
9	ABL2	1.85562663
10	DYRK1A	1.52048035
11	MAP3K5	1.13454362
12	SRPK1	1.07310619
13	VRK2	1.06566573
14	NME2	0.98814750
15	WNK3	0.86675174
16	TXK	0.81927576
17	CHEK2	0.77160572
18	MAP3K1	0.75189774
19	ADRBK2	0.68093708
20	PRKCQ	0.66775391
21	ZAK	0.64589566
22	TAF1	0.62894415
23	MAP4K2	0.58301671
24	NUAK1	0.58066464
25	VRK1	0.57851530
26	MAP3K8	0.56879190
27	TIE1	0.56528045
28	GRK1	0.56365763
29	MAP4K1	0.56242660
30	EIF2AK3	0.55933649
31	TLK1	0.54642357
32	WNK4	0.54226637
33	KDR	0.52673513
34	MST4	0.47944381
35	NEK1	0.47049488
36	MAP2K6	0.45403556
37	TSSK6	0.44037886
38	FRK	0.40827798
39	INSRR	0.37976669
40	BUB1	0.35602349
41	BMPR1B	0.32399725
42	PLK3	0.32033533
43	GRK7	0.31254299
44	BMPR2	0.30605611
45	RIPK4	0.27853844
46	CSNK1A1	0.24948632
47	OBSCN	0.24943626
48	MUSK	0.24936833
49	STK39	0.24870137
50	PDK2	0.24301675
51	ACVR1B	0.23893677
52	BCKDK	0.23364110
53	GRK6	0.22986495
54	GRK5	0.22799862
55	OXSR1	0.20267921
56	PLK4	0.19117607
57	NME1	0.19036439
58	MYLK	0.18680913
59	CSNK2A1	0.16911032
60	CSNK2A2	0.15816338
61	PASK	0.15547855
62	IGF1R	0.15434190
63	PIK3CG	0.14803950
64	TEC	0.14608463
65	PRKCG	0.13361180
66	STK16	0.13259074
67	PRKCA	0.12580055
68	TRIM28	0.11976440
69	TGFBR1	0.11893977
70	PRKACA	0.11686746
71	PLK2	0.11668751
72	PHKG1	0.11345257
73	PHKG2	0.11345257
74	TAOK3	0.11267150
75	AURKA	0.11243317
76	ITK	0.09585972
77	ADRBK1	0.08490509
78	MAP3K12	0.08452079
79	ABL1	0.08154359
80	PRKCD	0.08123396
81	MAPKAPK5	0.06776374
82	PINK1	0.06531212
83	KIT	0.06282722
84	MATK	0.06135822
85	PRKCB	0.05776136
86	DYRK2	0.04775531
87	PBK	0.03495305
88	DAPK3	0.03176596
89	DAPK1	0.03002086
90	SYK	0.02746758
91	CAMK2A	0.02536681
92	CSNK1E	0.01767233
93	RPS6KA5	0.01334572
94	EPHA4	0.00840753
95	PRKCE	0.00668085
96	MAPK13	0.00582276
97	TNIK	-0.0183043
98	EIF2AK2	-0.0118931
99	IKBKE	-0.0037701
100	LCK	-0.0025147

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	5.58909691
2	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	4.48818371
3	Proteasome_Homo sapiens_hsa03050	4.17274936
4	RNA polymerase_Homo sapiens_hsa03020	3.33369368
5	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.07904177
6	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.31400093
7	Butanoate metabolism_Homo sapiens_hsa00650	2.29358760
8	Fatty acid elongation_Homo sapiens_hsa00062	2.27178668
9	Taste transduction_Homo sapiens_hsa04742	2.15812865
10	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.14396243
11	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.90487353
12	One carbon pool by folate_Homo sapiens_hsa00670	1.86968013
13	Ribosome_Homo sapiens_hsa03010	1.77841655
14	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.75001116
15	Tryptophan metabolism_Homo sapiens_hsa00380	1.72532470
16	Oxidative phosphorylation_Homo sapiens_hsa00190	1.69719675
17	Primary immunodeficiency_Homo sapiens_hsa05340	1.67146913
18	Propanoate metabolism_Homo sapiens_hsa00640	1.57845601
19	beta-Alanine metabolism_Homo sapiens_hsa00410	1.47503908
20	Allograft rejection_Homo sapiens_hsa05330	1.41884659
21	Asthma_Homo sapiens_hsa05310	1.36771925
22	Parkinsons disease_Homo sapiens_hsa05012	1.36332972
23	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.36312843
24	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.33370734
25	Glycerolipid metabolism_Homo sapiens_hsa00561	1.31694070
26	Graft-versus-host disease_Homo sapiens_hsa05332	1.26725888
27	Caffeine metabolism_Homo sapiens_hsa00232	1.21715168
28	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.18630500
29	Fatty acid degradation_Homo sapiens_hsa00071	1.16534699
30	Peroxisome_Homo sapiens_hsa04146	1.13928391
31	Pyrimidine metabolism_Homo sapiens_hsa00240	1.13867200
32	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.13678047
33	Protein export_Homo sapiens_hsa03060	1.11142859
34	Huntingtons disease_Homo sapiens_hsa05016	1.08382426
35	Type I diabetes mellitus_Homo sapiens_hsa04940	1.03810099
36	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.02928870
37	Linoleic acid metabolism_Homo sapiens_hsa00591	0.97660046
38	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.94055817
39	Retinol metabolism_Homo sapiens_hsa00830	0.93335747
40	Sulfur metabolism_Homo sapiens_hsa00920	0.92177994
41	Fat digestion and absorption_Homo sapiens_hsa04975	0.88989448
42	Lysine degradation_Homo sapiens_hsa00310	0.87527475
43	Purine metabolism_Homo sapiens_hsa00230	0.85184913
44	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.83394540
45	Chemical carcinogenesis_Homo sapiens_hsa05204	0.81354240
46	Alzheimers disease_Homo sapiens_hsa05010	0.80448497
47	Phototransduction_Homo sapiens_hsa04744	0.79309311
48	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.79113461
49	Antigen processing and presentation_Homo sapiens_hsa04612	0.78513607
50	Fatty acid metabolism_Homo sapiens_hsa01212	0.78187535
51	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.76231348
52	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.72707536
53	RNA transport_Homo sapiens_hsa03013	0.72484205
54	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.72397132
55	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.71854581
56	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.71640352
57	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.71106342
58	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.69448233
59	Viral myocarditis_Homo sapiens_hsa05416	0.67558811
60	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.62682908
61	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.62626620
62	Cardiac muscle contraction_Homo sapiens_hsa04260	0.62127170
63	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.62032879
64	Nucleotide excision repair_Homo sapiens_hsa03420	0.61689988
65	Mineral absorption_Homo sapiens_hsa04978	0.60402554
66	RNA degradation_Homo sapiens_hsa03018	0.60250642
67	Renin-angiotensin system_Homo sapiens_hsa04614	0.60051506
68	Nicotine addiction_Homo sapiens_hsa05033	0.59336809
69	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.58659543
70	Amoebiasis_Homo sapiens_hsa05146	0.57713827
71	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.57383485
72	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.53825754
73	Rheumatoid arthritis_Homo sapiens_hsa05323	0.52887246
74	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.52587633
75	Nitrogen metabolism_Homo sapiens_hsa00910	0.52570221
76	Metabolic pathways_Homo sapiens_hsa01100	0.51288988
77	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.50208111
78	Protein digestion and absorption_Homo sapiens_hsa04974	0.49819752
79	Olfactory transduction_Homo sapiens_hsa04740	0.49071725
80	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.48636742
81	Selenocompound metabolism_Homo sapiens_hsa00450	0.46666379
82	Homologous recombination_Homo sapiens_hsa03440	0.44184304
83	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.44073875
84	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.42777499
85	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.41055322
86	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.39640083
87	Sulfur relay system_Homo sapiens_hsa04122	0.36301416
88	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.35775488
89	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.35458531
90	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.30848206
91	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.28868679
92	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.27451889
93	Complement and coagulation cascades_Homo sapiens_hsa04610	0.26779458
94	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.25005213
95	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.23328792
96	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.23230827
97	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.23062307
98	ABC transporters_Homo sapiens_hsa02010	0.21816630
99	Histidine metabolism_Homo sapiens_hsa00340	0.21234400
100	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.21115146

GAPDHP71

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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