ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	6.59019077
2	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	5.19700994
3	water-soluble vitamin biosynthetic process (GO:0042364)	5.07649561
4	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.53908400
5	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.32181034
6	ATP synthesis coupled proton transport (GO:0015986)	4.32181034
7	behavioral response to nicotine (GO:0035095)	4.28178782
8	protein complex biogenesis (GO:0070271)	4.21221220
9	mitochondrial respiratory chain complex assembly (GO:0033108)	3.91557570
10	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.87406737
11	NADH dehydrogenase complex assembly (GO:0010257)	3.87406737
12	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.87406737
13	response to pheromone (GO:0019236)	3.85159406
14	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.83094684
15	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.83094684
16	platelet dense granule organization (GO:0060155)	3.77881829
17	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.68332816
18	cytidine metabolic process (GO:0046087)	3.67822556
19	cytidine catabolic process (GO:0006216)	3.67822556
20	cytidine deamination (GO:0009972)	3.67822556
21	chaperone-mediated protein transport (GO:0072321)	3.61968758
22	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.58190733
23	sperm motility (GO:0030317)	3.49254943
24	protein polyglutamylation (GO:0018095)	3.35201030
25	fucose catabolic process (GO:0019317)	3.34143989
26	L-fucose metabolic process (GO:0042354)	3.34143989
27	L-fucose catabolic process (GO:0042355)	3.34143989
28	termination of RNA polymerase III transcription (GO:0006386)	3.23477588
29	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.23477588
30	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.19331327
31	negative regulation of telomere maintenance (GO:0032205)	3.17892711
32	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.16050729
33	rRNA modification (GO:0000154)	3.15065164
34	multicellular organism reproduction (GO:0032504)	3.13329016
35	protein neddylation (GO:0045116)	3.13157977
36	acrosome reaction (GO:0007340)	3.12921732
37	electron transport chain (GO:0022900)	3.10732259
38	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.09620590
39	respiratory electron transport chain (GO:0022904)	3.08028850
40	cellular ketone body metabolic process (GO:0046950)	3.05856309
41	epithelial cilium movement (GO:0003351)	3.05806620
42	respiratory chain complex IV assembly (GO:0008535)	3.04309027
43	rRNA methylation (GO:0031167)	3.02401364
44	protein-cofactor linkage (GO:0018065)	2.96096927
45	cytochrome complex assembly (GO:0017004)	2.93369132
46	axoneme assembly (GO:0035082)	2.85520163
47	intestinal epithelial cell development (GO:0060576)	2.85339546
48	negative regulation of mast cell activation (GO:0033004)	2.85002513
49	piRNA metabolic process (GO:0034587)	2.81930132
50	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.81885735
51	tryptophan catabolic process (GO:0006569)	2.80385623
52	indole-containing compound catabolic process (GO:0042436)	2.80385623
53	indolalkylamine catabolic process (GO:0046218)	2.80385623
54	ketone body metabolic process (GO:1902224)	2.79232203
55	indolalkylamine metabolic process (GO:0006586)	2.76716189
56	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.75976454
57	centriole replication (GO:0007099)	2.75468893
58	single strand break repair (GO:0000012)	2.71402617
59	regulation of cilium movement (GO:0003352)	2.71118427
60	hydrogen ion transmembrane transport (GO:1902600)	2.70298126
61	tRNA processing (GO:0008033)	2.68985794
62	proton transport (GO:0015992)	2.65281973
63	kidney morphogenesis (GO:0060993)	2.63826287
64	intracellular protein transmembrane import (GO:0044743)	2.63734238
65	retinal cone cell development (GO:0046549)	2.63254611
66	kynurenine metabolic process (GO:0070189)	2.62859281
67	neuron fate determination (GO:0048664)	2.62311743
68	hydrogen transport (GO:0006818)	2.61631394
69	tRNA modification (GO:0006400)	2.60807104
70	tryptophan metabolic process (GO:0006568)	2.60375312
71	protein K6-linked ubiquitination (GO:0085020)	2.57176076
72	ATP biosynthetic process (GO:0006754)	2.56552644
73	regulation of action potential (GO:0098900)	2.56160116
74	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.52398496
75	cilium movement (GO:0003341)	2.51644043
76	microtubule depolymerization (GO:0007019)	2.50331968
77	vitamin biosynthetic process (GO:0009110)	2.49662842
78	GPI anchor metabolic process (GO:0006505)	2.49545101
79	calcium ion-dependent exocytosis (GO:0017156)	2.49473769
80	organic cation transport (GO:0015695)	2.46262438
81	synaptic transmission, cholinergic (GO:0007271)	2.45590383
82	mannosylation (GO:0097502)	2.45315178
83	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.42378466
84	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.42348084
85	fusion of sperm to egg plasma membrane (GO:0007342)	2.41464126
86	male meiosis I (GO:0007141)	2.36276154
87	protein localization to cilium (GO:0061512)	2.35530806
88	pseudouridine synthesis (GO:0001522)	2.35216628
89	recombinational repair (GO:0000725)	2.33552188
90	cAMP catabolic process (GO:0006198)	2.33073380
91	DNA catabolic process, exonucleolytic (GO:0000738)	2.33021990
92	negative regulation of T cell differentiation in thymus (GO:0033085)	2.32953508
93	double-strand break repair via homologous recombination (GO:0000724)	2.31713335
94	spinal cord motor neuron differentiation (GO:0021522)	2.31339556
95	dopamine transport (GO:0015872)	2.31075404
96	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.31028458
97	membrane repolarization during cardiac muscle cell action potential (GO:0086013)	2.31017573
98	detection of light stimulus involved in visual perception (GO:0050908)	2.30974942
99	detection of light stimulus involved in sensory perception (GO:0050962)	2.30974942
100	intraciliary transport (GO:0042073)	2.30223596

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	VDR_22108803_ChIP-Seq_LS180_Human	3.48133775
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.44737694
3	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.99280394
4	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.84272831
5	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.83814907
6	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.82367504
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.68106433
8	EZH2_22144423_ChIP-Seq_EOC_Human	2.36118082
9	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.31838140
10	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.31047241
11	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.15359789
12	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.98961096
13	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.92845054
14	FUS_26573619_Chip-Seq_HEK293_Human	1.90746873
15	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.86534116
16	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.81878123
17	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.81419858
18	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.75356110
19	P300_19829295_ChIP-Seq_ESCs_Human	1.73171099
20	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.72409616
21	IGF1R_20145208_ChIP-Seq_DFB_Human	1.70573321
22	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.68565976
23	EWS_26573619_Chip-Seq_HEK293_Human	1.66374131
24	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.66219232
25	CBP_20019798_ChIP-Seq_JUKART_Human	1.66219232
26	GBX2_23144817_ChIP-Seq_PC3_Human	1.64845625
27	VDR_23849224_ChIP-Seq_CD4+_Human	1.64699970
28	ELK1_19687146_ChIP-ChIP_HELA_Human	1.64037415
29	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.59883812
30	MYC_18940864_ChIP-ChIP_HL60_Human	1.58287489
31	TAF15_26573619_Chip-Seq_HEK293_Human	1.58030112
32	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.57542476
33	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.57106360
34	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.55241007
35	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.54316318
36	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.53860548
37	TP53_22573176_ChIP-Seq_HFKS_Human	1.50731419
38	NANOG_19829295_ChIP-Seq_ESCs_Human	1.50670087
39	SOX2_19829295_ChIP-Seq_ESCs_Human	1.50670087
40	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.47500984
41	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.42325591
42	IRF1_19129219_ChIP-ChIP_H3396_Human	1.42056537
43	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.41431094
44	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.41113632
45	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.40738121
46	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.40738121
47	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.36955560
48	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.36422166
49	ER_23166858_ChIP-Seq_MCF-7_Human	1.35355495
50	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.34146075
51	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.32642415
52	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.27082302
53	NCOR_22424771_ChIP-Seq_293T_Human	1.25712740
54	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.22939956
55	MYC_19829295_ChIP-Seq_ESCs_Human	1.22672625
56	AR_20517297_ChIP-Seq_VCAP_Human	1.21956809
57	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.21140543
58	FOXP3_21729870_ChIP-Seq_TREG_Human	1.20227099
59	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.19125184
60	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.18147859
61	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.17932677
62	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.17123126
63	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.16790380
64	TAF2_19829295_ChIP-Seq_ESCs_Human	1.16687015
65	AR_25329375_ChIP-Seq_VCAP_Human	1.16441468
66	NANOG_20526341_ChIP-Seq_ESCs_Human	1.16140038
67	TCF4_22108803_ChIP-Seq_LS180_Human	1.15884352
68	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.13879354
69	BCAT_22108803_ChIP-Seq_LS180_Human	1.13706173
70	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.13120738
71	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.12590953
72	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.12590953
73	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.12264623
74	RNF2_27304074_Chip-Seq_NSC_Mouse	1.12147989
75	ERA_21632823_ChIP-Seq_H3396_Human	1.12120065
76	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.10675876
77	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.10133791
78	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.09254971
79	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.08986279
80	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.08457900
81	HOXB7_26014856_ChIP-Seq_BT474_Human	1.07900615
82	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.07518431
83	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.05970700
84	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.04490673
85	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.04442016
86	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.03867902
87	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.01082344
88	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.99141977
89	REST_21632747_ChIP-Seq_MESCs_Mouse	0.99083013
90	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.98598722
91	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.98084010
92	SMAD4_21799915_ChIP-Seq_A2780_Human	0.97369633
93	RUNX2_22187159_ChIP-Seq_PCA_Human	0.96881882
94	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.96674321
95	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.96009806
96	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.95567805
97	P53_21459846_ChIP-Seq_SAOS-2_Human	0.95213882
98	STAT3_23295773_ChIP-Seq_U87_Human	0.94487992
99	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.94225758
100	ERG_20517297_ChIP-Seq_VCAP_Human	0.92809553

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003283_abnormal_digestive_organ	4.61750149
2	MP0002102_abnormal_ear_morphology	3.00026233
3	MP0006292_abnormal_olfactory_placode	2.90063736
4	MP0002138_abnormal_hepatobiliary_system	2.73557865
5	MP0005410_abnormal_fertilization	2.48212436
6	MP0008877_abnormal_DNA_methylation	2.35293718
7	MP0003011_delayed_dark_adaptation	2.28223059
8	MP0008875_abnormal_xenobiotic_pharmacok	2.11961113
9	MP0003195_calcinosis	2.03604804
10	MP0001968_abnormal_touch/_nociception	2.02874838
11	MP0005551_abnormal_eye_electrophysiolog	2.02223852
12	MP0006072_abnormal_retinal_apoptosis	2.00705844
13	MP0002163_abnormal_gland_morphology	1.97136336
14	MP0001485_abnormal_pinna_reflex	1.96064417
15	MP0005646_abnormal_pituitary_gland	1.92161871
16	MP0005379_endocrine/exocrine_gland_phen	1.90336743
17	MP0002837_dystrophic_cardiac_calcinosis	1.89417802
18	MP0002876_abnormal_thyroid_physiology	1.86621063
19	MP0004142_abnormal_muscle_tone	1.80328083
20	MP0002736_abnormal_nociception_after	1.78165348
21	MP0004885_abnormal_endolymph	1.75948484
22	MP0005645_abnormal_hypothalamus_physiol	1.73691963
23	MP0005084_abnormal_gallbladder_morpholo	1.72995301
24	MP0002938_white_spotting	1.72906711
25	MP0005253_abnormal_eye_physiology	1.68663993
26	MP0008872_abnormal_physiological_respon	1.66629969
27	MP0003646_muscle_fatigue	1.61132238
28	MP0000372_irregular_coat_pigmentation	1.59318993
29	MP0000631_abnormal_neuroendocrine_gland	1.55099443
30	MP0009745_abnormal_behavioral_response	1.54261272
31	MP0003718_maternal_effect	1.52038506
32	MP0000049_abnormal_middle_ear	1.51274603
33	MP0002638_abnormal_pupillary_reflex	1.50259482
34	MP0002272_abnormal_nervous_system	1.48839569
35	MP0003878_abnormal_ear_physiology	1.47541391
36	MP0005377_hearing/vestibular/ear_phenot	1.47541391
37	MP0006276_abnormal_autonomic_nervous	1.47330961
38	MP0004742_abnormal_vestibular_system	1.45676185
39	MP0009046_muscle_twitch	1.44027046
40	MP0008789_abnormal_olfactory_epithelium	1.36699351
41	MP0002751_abnormal_autonomic_nervous	1.35371840
42	MP0009379_abnormal_foot_pigmentation	1.35240572
43	MP0001905_abnormal_dopamine_level	1.34975981
44	MP0002277_abnormal_respiratory_mucosa	1.28006823
45	MP0002234_abnormal_pharynx_morphology	1.25212771
46	MP0001986_abnormal_taste_sensitivity	1.23104064
47	MP0002733_abnormal_thermal_nociception	1.20376513
48	MP0003787_abnormal_imprinting	1.18692841
49	MP0002735_abnormal_chemical_nociception	1.14590855
50	MP0001984_abnormal_olfaction	1.14405446
51	MP0002095_abnormal_skin_pigmentation	1.09598823
52	MP0001929_abnormal_gametogenesis	1.08788532
53	MP0001486_abnormal_startle_reflex	1.08427358
54	MP0008058_abnormal_DNA_repair	1.08035448
55	MP0003698_abnormal_male_reproductive	1.06680442
56	MP0005389_reproductive_system_phenotype	1.05756987
57	MP0000026_abnormal_inner_ear	1.05513980
58	MP0005332_abnormal_amino_acid	1.03702096
59	MP0004147_increased_porphyrin_level	1.03194369
60	MP0001970_abnormal_pain_threshold	1.02505797
61	MP0001293_anophthalmia	1.02426548
62	MP0003119_abnormal_digestive_system	1.02003326
63	MP0005075_abnormal_melanosome_morpholog	1.00669139
64	MP0002160_abnormal_reproductive_system	1.00052723
65	MP0003136_yellow_coat_color	0.99806420
66	MP0003880_abnormal_central_pattern	0.99439899
67	MP0003252_abnormal_bile_duct	0.98948707
68	MP0003122_maternal_imprinting	0.98855295
69	MP0004145_abnormal_muscle_electrophysio	0.98201068
70	MP0001529_abnormal_vocalization	0.96091992
71	MP0000427_abnormal_hair_cycle	0.95389522
72	MP0004133_heterotaxia	0.94115172
73	MP0005499_abnormal_olfactory_system	0.93924382
74	MP0005394_taste/olfaction_phenotype	0.93924382
75	MP0005174_abnormal_tail_pigmentation	0.92651179
76	MP0003950_abnormal_plasma_membrane	0.91469632
77	MP0002734_abnormal_mechanical_nocicepti	0.90597874
78	MP0001501_abnormal_sleep_pattern	0.89831390
79	MP0004134_abnormal_chest_morphology	0.88347219
80	MP0003938_abnormal_ear_development	0.88340259
81	MP0002210_abnormal_sex_determination	0.86908933
82	MP0001963_abnormal_hearing_physiology	0.86743716
83	MP0005195_abnormal_posterior_eye	0.85560496
84	MP0002557_abnormal_social/conspecific_i	0.85242992
85	MP0002572_abnormal_emotion/affect_behav	0.84696208
86	MP0000613_abnormal_salivary_gland	0.84078768
87	MP0008995_early_reproductive_senescence	0.83646387
88	MP0003786_premature_aging	0.83377326
89	MP0002909_abnormal_adrenal_gland	0.82962613
90	MP0002067_abnormal_sensory_capabilities	0.82960830
91	MP0000516_abnormal_urinary_system	0.82207399
92	MP0005367_renal/urinary_system_phenotyp	0.82207399
93	MP0001919_abnormal_reproductive_system	0.81050342
94	MP0002064_seizures	0.80072727
95	MP0003121_genomic_imprinting	0.79968833
96	MP0003567_abnormal_fetal_cardiomyocyte	0.79116906
97	MP0010386_abnormal_urinary_bladder	0.77172674
98	MP0002752_abnormal_somatic_nervous	0.76216950
99	MP0003186_abnormal_redox_activity	0.75541155
100	MP0000653_abnormal_sex_gland	0.75458923

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	3.75017590
2	Mitochondrial inheritance (HP:0001427)	3.61116015
3	Pancreatic cysts (HP:0001737)	3.55088332
4	Pancreatic fibrosis (HP:0100732)	3.31348037
5	Abnormality of midbrain morphology (HP:0002418)	3.30451637
6	Molar tooth sign on MRI (HP:0002419)	3.30451637
7	Increased hepatocellular lipid droplets (HP:0006565)	3.25571329
8	Increased CSF lactate (HP:0002490)	3.23614682
9	Abnormal mitochondria in muscle tissue (HP:0008316)	3.22912541
10	Acute encephalopathy (HP:0006846)	3.22199975
11	Congenital stationary night blindness (HP:0007642)	3.21274640
12	Progressive macrocephaly (HP:0004481)	3.20681350
13	Renal Fanconi syndrome (HP:0001994)	3.17456257
14	Lipid accumulation in hepatocytes (HP:0006561)	3.14655522
15	Nephronophthisis (HP:0000090)	3.09523035
16	Abnormality of the renal cortex (HP:0011035)	3.04480324
17	Methylmalonic acidemia (HP:0002912)	2.96522706
18	True hermaphroditism (HP:0010459)	2.92909037
19	Hepatocellular necrosis (HP:0001404)	2.86760024
20	Pendular nystagmus (HP:0012043)	2.85328369
21	Methylmalonic aciduria (HP:0012120)	2.84331039
22	Abnormality of the renal medulla (HP:0100957)	2.79435317
23	Hepatic necrosis (HP:0002605)	2.76927813
24	Abnormal drinking behavior (HP:0030082)	2.73711251
25	Polydipsia (HP:0001959)	2.73711251
26	Attenuation of retinal blood vessels (HP:0007843)	2.67773735
27	Congenital, generalized hypertrichosis (HP:0004540)	2.66270357
28	Clumsiness (HP:0002312)	2.65959200
29	Abnormality of the labia minora (HP:0012880)	2.61225448
30	Abnormal rod and cone electroretinograms (HP:0008323)	2.53760820
31	Abolished electroretinogram (ERG) (HP:0000550)	2.52332898
32	Hypoplasia of the pons (HP:0012110)	2.51870612
33	Abnormality of the pons (HP:0007361)	2.47941120
34	Hyperglycinemia (HP:0002154)	2.44110345
35	Type II lissencephaly (HP:0007260)	2.40852544
36	Severe visual impairment (HP:0001141)	2.39953829
37	Polyuria (HP:0000103)	2.39617579
38	Optic disc pallor (HP:0000543)	2.38498476
39	Sclerocornea (HP:0000647)	2.34836401
40	Disproportionate short-trunk short stature (HP:0003521)	2.29080410
41	Renal cortical cysts (HP:0000803)	2.27839558
42	Cerebral edema (HP:0002181)	2.27792295
43	Glycosuria (HP:0003076)	2.24594644
44	Abnormality of urine glucose concentration (HP:0011016)	2.24594644
45	Adrenal hypoplasia (HP:0000835)	2.23991453
46	Abnormality of renal resorption (HP:0011038)	2.22790752
47	Tubular atrophy (HP:0000092)	2.22669184
48	Chronic hepatic failure (HP:0100626)	2.21958362
49	Abnormal respiratory epithelium morphology (HP:0012253)	2.19679025
50	Abnormal respiratory motile cilium morphology (HP:0005938)	2.19679025
51	Exertional dyspnea (HP:0002875)	2.19611847
52	Increased intramyocellular lipid droplets (HP:0012240)	2.19406117
53	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.18103783
54	3-Methylglutaconic aciduria (HP:0003535)	2.17237389
55	Cystic liver disease (HP:0006706)	2.15369014
56	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.15273789
57	Megalencephaly (HP:0001355)	2.14537583
58	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.06734016
59	Absent/shortened dynein arms (HP:0200106)	2.06734016
60	Decreased central vision (HP:0007663)	2.06260765
61	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.05430787
62	Abnormality of alanine metabolism (HP:0010916)	2.05430787
63	Hyperalaninemia (HP:0003348)	2.05430787
64	Increased serum lactate (HP:0002151)	2.05335017
65	Abnormal number of erythroid precursors (HP:0012131)	2.03409114
66	Increased corneal curvature (HP:0100692)	2.03277513
67	Keratoconus (HP:0000563)	2.03277513
68	Medial flaring of the eyebrow (HP:0010747)	2.03216292
69	Lactic acidosis (HP:0003128)	2.00034421
70	Abnormal urine output (HP:0012590)	1.98962552
71	Abnormal ciliary motility (HP:0012262)	1.97450005
72	Colon cancer (HP:0003003)	1.92545430
73	Abnormal biliary tract physiology (HP:0012439)	1.91605610
74	Bile duct proliferation (HP:0001408)	1.91605610
75	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.90417149
76	Reticulocytopenia (HP:0001896)	1.87972301
77	Poor suck (HP:0002033)	1.86970951
78	Aplasia/Hypoplasia involving the musculature (HP:0001460)	1.86351576
79	Bony spicule pigmentary retinopathy (HP:0007737)	1.85814176
80	Lethargy (HP:0001254)	1.84985018
81	Anencephaly (HP:0002323)	1.82709803
82	Respiratory failure (HP:0002878)	1.82053310
83	Hypomagnesemia (HP:0002917)	1.82035842
84	Abnormality of renal excretion (HP:0011036)	1.81068311
85	Type 2 muscle fiber atrophy (HP:0003554)	1.79931098
86	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.79387409
87	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.78289220
88	Increased muscle lipid content (HP:0009058)	1.77931229
89	Abnormality of serum amino acid levels (HP:0003112)	1.77232496
90	Abnormality of cells of the erythroid lineage (HP:0012130)	1.77119361
91	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.73735393
92	Congenital sensorineural hearing impairment (HP:0008527)	1.72792360
93	Abnormality of macular pigmentation (HP:0008002)	1.72560444
94	Abnormal respiratory motile cilium physiology (HP:0012261)	1.72207219
95	Severe muscular hypotonia (HP:0006829)	1.69441292
96	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.69097555
97	Cerebellar dysplasia (HP:0007033)	1.68611808
98	Short tibia (HP:0005736)	1.68584806
99	Thyroid-stimulating hormone excess (HP:0002925)	1.68362471
100	Ketosis (HP:0001946)	1.68194682

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TLK1	5.33133547
2	MAP4K2	3.71221259
3	FRK	3.53895345
4	BUB1	2.84745422
5	NUAK1	2.65861312
6	ZAK	2.63620345
7	ADRBK2	2.61308191
8	PLK4	2.53767594
9	VRK2	2.44617828
10	GRK1	2.33373881
11	BMPR1B	2.28130407
12	INSRR	2.17940666
13	WNK3	1.92860550
14	VRK1	1.84165389
15	WNK4	1.81266682
16	PINK1	1.81010938
17	TXK	1.74343370
18	PLK2	1.60807873
19	TRIM28	1.56068122
20	BCKDK	1.54572716
21	TAOK3	1.47472029
22	LIMK1	1.29185625
23	PHKG2	1.25360112
24	PHKG1	1.25360112
25	STK39	1.25135742
26	TIE1	1.23508971
27	STK16	1.23422540
28	MAPK13	1.19859163
29	MST4	1.12043889
30	DYRK2	1.10857107
31	OXSR1	1.10160034
32	CSNK1G1	1.04565613
33	NME1	1.01695771
34	STK38L	1.00529762
35	CSNK1G3	0.98175363
36	TNIK	0.97029049
37	PRKCG	0.94437903
38	CSNK1G2	0.93308762
39	TESK1	0.91748544
40	PLK3	0.90203271
41	TGFBR1	0.82897857
42	DAPK2	0.77685492
43	TAF1	0.76763367
44	MKNK2	0.76054116
45	PAK3	0.72329817
46	MUSK	0.69817061
47	RPS6KA5	0.68959312
48	PRKCE	0.68567159
49	IKBKB	0.68353922
50	ACVR1B	0.66885399
51	ADRBK1	0.66593273
52	MAP2K7	0.64935295
53	PDK2	0.63271424
54	CSNK1A1L	0.62919451
55	NEK2	0.60253292
56	PIK3CA	0.59635413
57	MAPK15	0.57624025
58	PRKCQ	0.56807886
59	CSNK1A1	0.55296312
60	MAP3K4	0.53180170
61	PLK1	0.51662811
62	EPHB2	0.51027209
63	CASK	0.50956927
64	CDC7	0.50830753
65	PRKACA	0.50014071
66	GRK5	0.48212429
67	PTK2B	0.47387771
68	MAPKAPK5	0.47308470
69	MARK1	0.45399171
70	BRSK2	0.44529658
71	PRKG1	0.43992733
72	FGFR2	0.43716257
73	PIK3CG	0.43167354
74	PNCK	0.42414783
75	NTRK3	0.42019811
76	OBSCN	0.40935145
77	MAP2K6	0.40527746
78	WNK1	0.40061119
79	PRKCI	0.39768693
80	CCNB1	0.39648821
81	PKN1	0.39313700
82	STK3	0.39237188
83	BCR	0.38716330
84	CDK8	0.37777176
85	KDR	0.37174429
86	EPHA4	0.36455702
87	MYLK	0.35878684
88	CSNK2A1	0.35514405
89	PRKCA	0.34653559
90	PASK	0.33442868
91	CAMK2A	0.33277636
92	CAMK1	0.31476774
93	KIT	0.30862920
94	AURKA	0.30494300
95	NTRK2	0.30320648
96	TEC	0.29409574
97	CSNK2A2	0.29217851
98	GRK7	0.28866940
99	WEE1	0.26592741
100	IGF1R	0.26191172

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.62972213
2	Parkinsons disease_Homo sapiens_hsa05012	2.91848599
3	Ribosome_Homo sapiens_hsa03010	2.67940460
4	Proteasome_Homo sapiens_hsa03050	2.63041787
5	Protein export_Homo sapiens_hsa03060	2.55718975
6	RNA polymerase_Homo sapiens_hsa03020	2.49101382
7	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.35944315
8	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.10205815
9	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.07631369
10	Huntingtons disease_Homo sapiens_hsa05016	2.05879259
11	Phototransduction_Homo sapiens_hsa04744	1.96248526
12	Alzheimers disease_Homo sapiens_hsa05010	1.94319898
13	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.90941711
14	Cardiac muscle contraction_Homo sapiens_hsa04260	1.87523055
15	Butanoate metabolism_Homo sapiens_hsa00650	1.86203521
16	Selenocompound metabolism_Homo sapiens_hsa00450	1.85488593
17	Sulfur relay system_Homo sapiens_hsa04122	1.72364163
18	Linoleic acid metabolism_Homo sapiens_hsa00591	1.70050467
19	Homologous recombination_Homo sapiens_hsa03440	1.65734129
20	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.64966416
21	Nitrogen metabolism_Homo sapiens_hsa00910	1.56532047
22	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.53696844
23	Basal transcription factors_Homo sapiens_hsa03022	1.50845954
24	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.50653930
25	Caffeine metabolism_Homo sapiens_hsa00232	1.45356433
26	Tryptophan metabolism_Homo sapiens_hsa00380	1.42008365
27	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.41322741
28	RNA degradation_Homo sapiens_hsa03018	1.37335310
29	Fanconi anemia pathway_Homo sapiens_hsa03460	1.36787321
30	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.36624843
31	One carbon pool by folate_Homo sapiens_hsa00670	1.36497374
32	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.30360056
33	Nicotine addiction_Homo sapiens_hsa05033	1.29038677
34	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.25660887
35	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.23205907
36	Propanoate metabolism_Homo sapiens_hsa00640	1.21668283
37	Primary immunodeficiency_Homo sapiens_hsa05340	1.19144908
38	Pyrimidine metabolism_Homo sapiens_hsa00240	1.16881117
39	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.13575394
40	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.13561098
41	Purine metabolism_Homo sapiens_hsa00230	1.12821952
42	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.12582086
43	Sulfur metabolism_Homo sapiens_hsa00920	1.12092613
44	Type I diabetes mellitus_Homo sapiens_hsa04940	1.09352439
45	Peroxisome_Homo sapiens_hsa04146	1.07468556
46	Ether lipid metabolism_Homo sapiens_hsa00565	1.06871269
47	Asthma_Homo sapiens_hsa05310	1.03882603
48	Olfactory transduction_Homo sapiens_hsa04740	1.01079795
49	Allograft rejection_Homo sapiens_hsa05330	1.00214100
50	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.99832771
51	Collecting duct acid secretion_Homo sapiens_hsa04966	0.95982895
52	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.95898982
53	Chemical carcinogenesis_Homo sapiens_hsa05204	0.93805348
54	Retinol metabolism_Homo sapiens_hsa00830	0.85770737
55	Taste transduction_Homo sapiens_hsa04742	0.85275440
56	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.84106267
57	Mismatch repair_Homo sapiens_hsa03430	0.83558473
58	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.83065873
59	Regulation of autophagy_Homo sapiens_hsa04140	0.82818019
60	Morphine addiction_Homo sapiens_hsa05032	0.82580363
61	Graft-versus-host disease_Homo sapiens_hsa05332	0.82320948
62	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.80733339
63	Folate biosynthesis_Homo sapiens_hsa00790	0.80695788
64	Metabolic pathways_Homo sapiens_hsa01100	0.78705265
65	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.77045567
66	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.76878516
67	Fat digestion and absorption_Homo sapiens_hsa04975	0.76098661
68	DNA replication_Homo sapiens_hsa03030	0.71780113
69	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.69500553
70	Nucleotide excision repair_Homo sapiens_hsa03420	0.69365902
71	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.66738019
72	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.66651585
73	Fatty acid elongation_Homo sapiens_hsa00062	0.65440404
74	Glycerolipid metabolism_Homo sapiens_hsa00561	0.65070026
75	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.64672877
76	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.63376449
77	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.61571052
78	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.61504054
79	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.61338447
80	Insulin secretion_Homo sapiens_hsa04911	0.60662630
81	beta-Alanine metabolism_Homo sapiens_hsa00410	0.59335578
82	Non-homologous end-joining_Homo sapiens_hsa03450	0.58737154
83	Base excision repair_Homo sapiens_hsa03410	0.57242491
84	Antigen processing and presentation_Homo sapiens_hsa04612	0.52644939
85	RNA transport_Homo sapiens_hsa03013	0.51859064
86	GABAergic synapse_Homo sapiens_hsa04727	0.51027964
87	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.50824362
88	Fatty acid degradation_Homo sapiens_hsa00071	0.50110417
89	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.50108371
90	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.49394606
91	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.47132205
92	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.46202389
93	Rheumatoid arthritis_Homo sapiens_hsa05323	0.44692425
94	Mineral absorption_Homo sapiens_hsa04978	0.44490546
95	Serotonergic synapse_Homo sapiens_hsa04726	0.39201081
96	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.38286708
97	Steroid biosynthesis_Homo sapiens_hsa00100	0.37968883
98	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.33201955
99	ABC transporters_Homo sapiens_hsa02010	0.32858261
100	Glutathione metabolism_Homo sapiens_hsa00480	0.31899516

GAPDHP72

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »