ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	negative regulation of Ras GTPase activity (GO:0034261)	9.04156572
2	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	9.01899123
3	positive regulation of mitotic sister chromatid separation (GO:1901970)	9.01899123
4	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	9.01899123
5	eosinophil chemotaxis (GO:0048245)	8.93259360
6	ribosomal small subunit assembly (GO:0000028)	8.92919182
7	eosinophil migration (GO:0072677)	8.07769647
8	negative regulation of T cell receptor signaling pathway (GO:0050860)	7.91114974
9	regulation of sister chromatid cohesion (GO:0007063)	7.34119473
10	L-fucose catabolic process (GO:0042355)	7.01846977
11	fucose catabolic process (GO:0019317)	7.01846977
12	L-fucose metabolic process (GO:0042354)	7.01846977
13	regulation of mononuclear cell migration (GO:0071675)	6.88629402
14	negative regulation of peptidyl-threonine phosphorylation (GO:0010801)	6.71646107
15	branch elongation of an epithelium (GO:0060602)	6.38207396
16	negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)	6.16294174
17	negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)	6.02060368
18	coenzyme A biosynthetic process (GO:0015937)	5.88703887
19	positive regulation of chromosome segregation (GO:0051984)	5.71918100
20	macrophage chemotaxis (GO:0048246)	5.69404500
21	vesicle fusion (GO:0006906)	5.67454266
22	autophagic vacuole fusion (GO:0000046)	5.12556675
23	localization within membrane (GO:0051668)	5.08006285
24	monocyte chemotaxis (GO:0002548)	4.92365233
25	peptidyl-lysine dimethylation (GO:0018027)	4.79990959
26	regulation of T cell receptor signaling pathway (GO:0050856)	4.78198675
27	protein import into peroxisome matrix (GO:0016558)	4.74761265
28	positive regulation of calcium ion import (GO:0090280)	4.73283792
29	axis elongation (GO:0003401)	4.53784746
30	seminiferous tubule development (GO:0072520)	4.50197348
31	double-strand break repair via nonhomologous end joining (GO:0006303)	4.49870386
32	non-recombinational repair (GO:0000726)	4.49870386
33	organ growth (GO:0035265)	4.39558178
34	proteasome assembly (GO:0043248)	4.34291399
35	establishment of mitotic spindle orientation (GO:0000132)	4.23016597
36	organelle membrane fusion (GO:0090174)	4.09769254
37	preassembly of GPI anchor in ER membrane (GO:0016254)	4.07886532
38	DNA deamination (GO:0045006)	4.07825466
39	metallo-sulfur cluster assembly (GO:0031163)	4.04046983
40	iron-sulfur cluster assembly (GO:0016226)	4.04046983
41	DNA demethylation (GO:0080111)	4.00586154
42	detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)	3.90173024
43	oxidative demethylation (GO:0070989)	3.88379731
44	regulation of nitric-oxide synthase biosynthetic process (GO:0051769)	3.87738085
45	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	3.87609852
46	establishment of mitotic spindle localization (GO:0040001)	3.83308993
47	negative regulation of GTPase activity (GO:0034260)	3.80512297
48	negative regulation of GTP catabolic process (GO:0033125)	3.80512297
49	positive chemotaxis (GO:0050918)	3.74771717
50	ribonucleoside bisphosphate biosynthetic process (GO:0034030)	3.69624099
51	nucleoside bisphosphate biosynthetic process (GO:0033866)	3.69624099
52	purine nucleoside bisphosphate biosynthetic process (GO:0034033)	3.69624099
53	fucose metabolic process (GO:0006004)	3.67844797
54	coenzyme A metabolic process (GO:0015936)	3.66534941
55	pantothenate metabolic process (GO:0015939)	3.66233211
56	intracellular protein transmembrane import (GO:0044743)	3.61070018
57	acrosome assembly (GO:0001675)	3.56878062
58	fucosylation (GO:0036065)	3.56308601
59	telomere maintenance via recombination (GO:0000722)	3.50849347
60	negative regulation of circadian rhythm (GO:0042754)	3.50488489
61	protein localization to peroxisome (GO:0072662)	3.46658213
62	protein targeting to peroxisome (GO:0006625)	3.46658213
63	establishment of protein localization to peroxisome (GO:0072663)	3.46658213
64	establishment of spindle orientation (GO:0051294)	3.45855307
65	DNA dealkylation (GO:0035510)	3.42077473
66	detection of chemical stimulus involved in sensory perception of taste (GO:0050912)	3.35606180
67	DNA integration (GO:0015074)	3.34789685
68	organelle fusion (GO:0048284)	3.33089902
69	regulation of antigen receptor-mediated signaling pathway (GO:0050854)	3.30759019
70	regulation of fibroblast growth factor receptor signaling pathway (GO:0040036)	3.26851858
71	cytidine metabolic process (GO:0046087)	3.24861719
72	cytidine catabolic process (GO:0006216)	3.24861719
73	cytidine deamination (GO:0009972)	3.24861719
74	regulation of autophagic vacuole assembly (GO:2000785)	3.20301191
75	regulation of beta-amyloid formation (GO:1902003)	3.19148871
76	histone H3-K9 methylation (GO:0051567)	3.16441107
77	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.16120654
78	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.12169844
79	membrane budding (GO:0006900)	3.10250685
80	peroxisomal transport (GO:0043574)	3.06539809
81	imidazole-containing compound metabolic process (GO:0052803)	3.01376205
82	regulation of T cell apoptotic process (GO:0070232)	2.97122533
83	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.97068583
84	ATP synthesis coupled proton transport (GO:0015986)	2.97068583
85	regulation of stem cell maintenance (GO:2000036)	2.90859452
86	mitotic recombination (GO:0006312)	2.90288428
87	termination of RNA polymerase III transcription (GO:0006386)	2.88238350
88	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.88238350
89	GPI anchor biosynthetic process (GO:0006506)	2.86207550
90	positive regulation of interleukin-1 beta secretion (GO:0050718)	2.85264503
91	negative regulation of macroautophagy (GO:0016242)	2.84129034
92	regulation of cellular amino acid metabolic process (GO:0006521)	2.83466447
93	ER to Golgi vesicle-mediated transport (GO:0006888)	2.82722087
94	regulation of calcium ion import (GO:0090279)	2.80789191
95	protein sumoylation (GO:0016925)	2.79299274
96	sodium-independent organic anion transport (GO:0043252)	2.78959518
97	GPI anchor metabolic process (GO:0006505)	2.77917963
98	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.77036533
99	protein prenylation (GO:0018342)	10.4282491
100	prenylation (GO:0097354)	10.4282491

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	8.37936297
2	GATA1_22025678_ChIP-Seq_K562_Human	6.23525517
3	VDR_22108803_ChIP-Seq_LS180_Human	5.53515042
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.91257184
5	NOTCH1_21737748_ChIP-Seq_TLL_Human	3.55633895
6	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.39444211
7	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.11940247
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.87607709
9	YY1_21170310_ChIP-Seq_MESCs_Mouse	2.70223288
10	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.54830928
11	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.47769983
12	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.41219369
13	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.38070999
14	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.36768266
15	EZH2_22144423_ChIP-Seq_EOC_Human	2.36018885
16	AR_21572438_ChIP-Seq_LNCaP_Human	2.24177953
17	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.22275916
18	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.21474975
19	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.17704915
20	SRY_22984422_ChIP-ChIP_TESTIS_Rat	2.12690748
21	ZNF274_21170338_ChIP-Seq_K562_Hela	2.10417288
22	IRF1_19129219_ChIP-ChIP_H3396_Human	2.03100728
23	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.92062009
24	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.86577420
25	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.80370878
26	VDR_23849224_ChIP-Seq_CD4+_Human	1.79979874
27	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.79830162
28	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.74944715
29	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.70133273
30	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.67081615
31	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.65712709
32	TAF15_26573619_Chip-Seq_HEK293_Human	1.46378011
33	ZIC3_20872845_ChIP-ChIP_MESCs_Mouse	1.42447480
34	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.41247871
35	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.39463713
36	TP53_22573176_ChIP-Seq_HFKS_Human	1.36532765
37	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.33890652
38	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.28121129
39	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.28121129
40	ELK1_19687146_ChIP-ChIP_HELA_Human	1.24163257
41	FOXP3_21729870_ChIP-Seq_TREG_Human	1.23929234
42	BCAT_22108803_ChIP-Seq_LS180_Human	1.23511800
43	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.22520381
44	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.17027130
45	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.15839372
46	FUS_26573619_Chip-Seq_HEK293_Human	1.15798066
47	RXR_22108803_ChIP-Seq_LS180_Human	1.14514599
48	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.13445357
49	P300_19829295_ChIP-Seq_ESCs_Human	1.12685245
50	GABP_19822575_ChIP-Seq_HepG2_Human	1.11554579
51	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.10550180
52	ZNF263_19887448_ChIP-Seq_K562_Human	1.08156651
53	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.07519064
54	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.06420116
55	GBX2_23144817_ChIP-Seq_PC3_Human	1.04590489
56	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.04219806
57	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.03201505
58	NANOG_20526341_ChIP-Seq_ESCs_Human	1.00772251
59	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.00465284
60	CREB1_15753290_ChIP-ChIP_HEK293T_Human	0.99472746
61	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.98882721
62	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.98882721
63	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.98134539
64	NANOG_19829295_ChIP-Seq_ESCs_Human	0.97866661
65	SOX2_19829295_ChIP-Seq_ESCs_Human	0.97866661
66	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.97421735
67	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.95319958
68	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.95222507
69	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.93489278
70	HTT_18923047_ChIP-ChIP_STHdh_Human	0.93225405
71	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.93176974
72	GATA3_26560356_Chip-Seq_TH1_Human	0.91658704
73	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.90990071
74	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.89615502
75	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.87257442
76	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.84675298
77	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.83038721
78	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.81067848
79	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.81047022
80	TCF4_22108803_ChIP-Seq_LS180_Human	0.81006671
81	TTF2_22483619_ChIP-Seq_HELA_Human	0.80128364
82	ERG_20517297_ChIP-Seq_VCAP_Human	0.78125551
83	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.77977819
84	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.77478572
85	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.76025255
86	AR_20517297_ChIP-Seq_VCAP_Human	0.75782282
87	NCOR_22424771_ChIP-Seq_293T_Human	0.75574274
88	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.75386204
89	GATA3_21867929_ChIP-Seq_TH1_Mouse	0.74793812
90	CBP_20019798_ChIP-Seq_JUKART_Human	0.73219954
91	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.73219954
92	WDR5_24793694_ChIP-Seq_LNCAP_Human	0.72943034
93	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	0.72053713
94	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.69828785
95	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.69771275
96	MYC_18940864_ChIP-ChIP_HL60_Human	0.69662548
97	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.69401690
98	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.68933793
99	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.68866386
100	DCP1A_22483619_ChIP-Seq_HELA_Human	0.68795778

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003303_peritoneal_inflammation	6.42093010
2	MP0006082_CNS_inflammation	4.26450000
3	MP0001663_abnormal_digestive_system	2.78157375
4	MP0001919_abnormal_reproductive_system	2.75287012
5	MP0000467_abnormal_esophagus_morphology	2.53615334
6	MP0002751_abnormal_autonomic_nervous	2.45404058
7	MP0001664_abnormal_digestion	2.43955529
8	MP0005389_reproductive_system_phenotype	2.16103733
9	MP0005381_digestive/alimentary_phenotyp	2.01692163
10	MP0000566_synostosis	10.2947249
11	MP0006292_abnormal_olfactory_placode	1.95239179
12	MP0002876_abnormal_thyroid_physiology	1.93730057
13	MP0003937_abnormal_limbs/digits/tail_de	1.81312910
14	MP0003115_abnormal_respiratory_system	1.60795094
15	MP0005645_abnormal_hypothalamus_physiol	1.59372887
16	MP0001293_anophthalmia	1.48172167
17	MP0005084_abnormal_gallbladder_morpholo	1.47789522
18	MP0003878_abnormal_ear_physiology	1.42594086
19	MP0005377_hearing/vestibular/ear_phenot	1.42594086
20	MP0003880_abnormal_central_pattern	1.40674517
21	MP0002102_abnormal_ear_morphology	1.38198663
22	MP0005166_decreased_susceptibility_to	1.34666234
23	MP0006276_abnormal_autonomic_nervous	1.28721157
24	MP0008058_abnormal_DNA_repair	1.27257645
25	MP0000383_abnormal_hair_follicle	1.25756609
26	MP0001286_abnormal_eye_development	1.25434009
27	MP0001764_abnormal_homeostasis	1.25099195
28	MP0003122_maternal_imprinting	1.22695004
29	MP0000372_irregular_coat_pigmentation	1.21855037
30	MP0005671_abnormal_response_to	1.19435469
31	MP0000534_abnormal_ureter_morphology	1.17781648
32	MP0008875_abnormal_xenobiotic_pharmacok	1.15850851
33	MP0000026_abnormal_inner_ear	1.09983903
34	MP0001963_abnormal_hearing_physiology	1.07052671
35	MP0004142_abnormal_muscle_tone	1.04545485
36	MP0003136_yellow_coat_color	1.04491068
37	MP0002163_abnormal_gland_morphology	1.01989836
38	MP0005253_abnormal_eye_physiology	1.00488159
39	MP0005551_abnormal_eye_electrophysiolog	0.99597292
40	MP0003942_abnormal_urinary_system	0.98772814
41	MP0002210_abnormal_sex_determination	0.98495789
42	MP0000049_abnormal_middle_ear	0.98478130
43	MP0008872_abnormal_physiological_respon	0.95704895
44	MP0009379_abnormal_foot_pigmentation	0.95614521
45	MP0001915_intracranial_hemorrhage	0.95441121
46	MP0002234_abnormal_pharynx_morphology	0.94657030
47	MP0003011_delayed_dark_adaptation	0.94302629
48	MP0002736_abnormal_nociception_after	0.91545940
49	MP0002837_dystrophic_cardiac_calcinosis	0.90679669
50	MP0003283_abnormal_digestive_organ	0.90577914
51	MP0008789_abnormal_olfactory_epithelium	0.90541573
52	MP0008877_abnormal_DNA_methylation	0.88838403
53	MP0002160_abnormal_reproductive_system	0.88299972
54	MP0000428_abnormal_craniofacial_morphol	0.87092038
55	MP0000490_abnormal_crypts_of	0.86705658
56	MP0002184_abnormal_innervation	0.86262750
57	MP0001529_abnormal_vocalization	0.86110250
58	MP0001485_abnormal_pinna_reflex	0.83780176
59	MP0001968_abnormal_touch/_nociception	0.83550120
60	MP0000358_abnormal_cell_content/	0.81895192
61	MP0004145_abnormal_muscle_electrophysio	0.81418620
62	MP0002109_abnormal_limb_morphology	0.80775231
63	MP0001905_abnormal_dopamine_level	0.80561654
64	MP0002138_abnormal_hepatobiliary_system	0.80402911
65	MP0002019_abnormal_tumor_incidence	0.79854446
66	MP0003195_calcinosis	0.79650572
67	MP0004885_abnormal_endolymph	0.79138759
68	MP0005085_abnormal_gallbladder_physiolo	0.78191568
69	MP0002938_white_spotting	0.75633922
70	MP0002752_abnormal_somatic_nervous	0.75505897
71	MP0006072_abnormal_retinal_apoptosis	0.74955583
72	MP0003646_muscle_fatigue	0.74319852
73	MP0010678_abnormal_skin_adnexa	0.72813657
74	MP0005646_abnormal_pituitary_gland	0.72631571
75	MP0002653_abnormal_ependyma_morphology	0.70601763
76	MP0005195_abnormal_posterior_eye	0.68797463
77	MP0002272_abnormal_nervous_system	0.67802103
78	MP0002822_catalepsy	0.67583020
79	MP0005501_abnormal_skin_physiology	0.67235996
80	MP0004133_heterotaxia	0.66306763
81	MP0001986_abnormal_taste_sensitivity	0.66241349
82	MP0005379_endocrine/exocrine_gland_phen	0.65675586
83	MP0005394_taste/olfaction_phenotype	0.64239094
84	MP0005499_abnormal_olfactory_system	0.64239094
85	MP0003936_abnormal_reproductive_system	0.63331314
86	MP0000631_abnormal_neuroendocrine_gland	0.61818954
87	MP0002735_abnormal_chemical_nociception	0.61431730
88	MP0002115_abnormal_skeleton_extremities	0.60131918
89	MP0005360_urolithiasis	0.59977110
90	MP0005197_abnormal_uvea_morphology	0.59893825
91	MP0002095_abnormal_skin_pigmentation	0.58497942
92	MP0005391_vision/eye_phenotype	0.58238362
93	MP0005423_abnormal_somatic_nervous	0.57941060
94	MP0009745_abnormal_behavioral_response	0.56546632
95	MP0008932_abnormal_embryonic_tissue	0.56227653
96	MP0009785_altered_susceptibility_to	0.56079945
97	MP0002277_abnormal_respiratory_mucosa	0.54559262
98	MP0003763_abnormal_thymus_physiology	0.54545401
99	MP0009763_increased_sensitivity_to	0.54141932
100	MP0003252_abnormal_bile_duct	0.53733172

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	8.74803225
2	Duplicated collecting system (HP:0000081)	6.90401861
3	Abnormality of the renal collecting system (HP:0004742)	6.54741179
4	Long foot (HP:0001833)	5.66007923
5	Large for gestational age (HP:0001520)	5.31247081
6	Adactyly (HP:0009776)	5.06165509
7	Hypoplastic pelvis (HP:0008839)	4.88633558
8	Abnormality of fatty-acid metabolism (HP:0004359)	4.72640082
9	Progressive muscle weakness (HP:0003323)	4.27533838
10	Brushfield spots (HP:0001088)	4.14249280
11	Dry hair (HP:0011359)	4.04901711
12	Acute lymphatic leukemia (HP:0006721)	3.88162898
13	Ureteral stenosis (HP:0000071)	3.67427326
14	Pulmonary artery stenosis (HP:0004415)	3.54712548
15	Autoamputation (HP:0001218)	3.53976715
16	Ureteral duplication (HP:0000073)	3.51239400
17	Menstrual irregularities (HP:0000858)	3.34456742
18	Severe muscular hypotonia (HP:0006829)	3.31089173
19	Ureteral obstruction (HP:0006000)	3.26224717
20	Acute necrotizing encephalopathy (HP:0006965)	3.25340177
21	Hypoplastic nipples (HP:0002557)	3.21819893
22	Steatorrhea (HP:0002570)	3.15123178
23	Mitochondrial inheritance (HP:0001427)	3.04917462
24	Broad-based gait (HP:0002136)	3.03277388
25	Lactic acidosis (HP:0003128)	2.98861373
26	Abnormal mitochondria in muscle tissue (HP:0008316)	2.91722309
27	Reduced subcutaneous adipose tissue (HP:0003758)	2.85066227
28	Hepatocellular necrosis (HP:0001404)	2.80135150
29	Acute encephalopathy (HP:0006846)	2.78653485
30	Increased CSF lactate (HP:0002490)	2.74081390
31	Decreased muscle mass (HP:0003199)	2.72239063
32	Increased serum lactate (HP:0002151)	2.58682162
33	Rhabdomyolysis (HP:0003201)	2.56010627
34	Anhidrosis (HP:0000970)	2.54507496
35	Progressive macrocephaly (HP:0004481)	2.52862441
36	Fat malabsorption (HP:0002630)	2.50517653
37	Epiphyseal stippling (HP:0010655)	2.49489746
38	Sudden death (HP:0001699)	2.49239270
39	Hepatic necrosis (HP:0002605)	2.47559862
40	Transposition of the great arteries (HP:0001669)	2.47169829
41	Abnormal connection of the cardiac segments (HP:0011545)	2.47169829
42	Abnormal ventriculo-arterial connection (HP:0011563)	2.47169829
43	Clubbing of toes (HP:0100760)	2.45013025
44	Wide intermamillary distance (HP:0006610)	2.44261725
45	Increased number of teeth (HP:0011069)	2.43468391
46	Decreased lacrimation (HP:0000633)	2.42457990
47	Pancreatic fibrosis (HP:0100732)	2.41161419
48	Abnormal auditory evoked potentials (HP:0006958)	2.38627905
49	Increased hepatocellular lipid droplets (HP:0006565)	2.33669767
50	Pancreatic cysts (HP:0001737)	2.32660312
51	Chorioretinal coloboma (HP:0000567)	2.31766536
52	Polymicrogyria (HP:0002126)	2.29551683
53	3-Methylglutaconic aciduria (HP:0003535)	2.24799130
54	Lipid accumulation in hepatocytes (HP:0006561)	2.23436421
55	True hermaphroditism (HP:0010459)	2.23304003
56	Septo-optic dysplasia (HP:0100842)	2.21170307
57	Myoglobinuria (HP:0002913)	2.20149528
58	Female pseudohermaphroditism (HP:0010458)	2.19964510
59	Polyneuropathy (HP:0001271)	2.19592845
60	Exercise intolerance (HP:0003546)	2.19109188
61	CNS demyelination (HP:0007305)	2.18925885
62	Palmoplantar hyperkeratosis (HP:0000972)	2.18909374
63	Depressed nasal ridge (HP:0000457)	2.16748408
64	Respiratory failure (HP:0002878)	2.15911336
65	Congenital stationary night blindness (HP:0007642)	2.14020872
66	Cerebral edema (HP:0002181)	2.12167365
67	Renal Fanconi syndrome (HP:0001994)	2.11541124
68	Abnormality of the labia minora (HP:0012880)	2.11337687
69	Posterior embryotoxon (HP:0000627)	2.09583772
70	Palmar hyperkeratosis (HP:0010765)	2.06062087
71	Abnormality of the line of Schwalbe (HP:0008048)	2.04350146
72	Spastic tetraplegia (HP:0002510)	1.97510880
73	Pendular nystagmus (HP:0012043)	1.93949733
74	Supernumerary spleens (HP:0009799)	1.91823355
75	Anxiety (HP:0000739)	1.85549483
76	Reticulocytopenia (HP:0001896)	1.83775433
77	Abnormality of midbrain morphology (HP:0002418)	1.76797348
78	Molar tooth sign on MRI (HP:0002419)	1.76797348
79	Abnormal epiphyseal ossification (HP:0010656)	1.76503549
80	Aplasia/Hypoplasia of the nipples (HP:0006709)	1.76211932
81	Postnatal microcephaly (HP:0005484)	1.74137565
82	Abnormality of vision evoked potentials (HP:0000649)	1.73907751
83	Overfolded helix (HP:0000396)	1.73553051
84	Optic disc pallor (HP:0000543)	1.71314624
85	Flat face (HP:0012368)	1.69602463
86	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.68929963
87	Plantar hyperkeratosis (HP:0007556)	1.65323732
88	Thickened nuchal skin fold (HP:0000474)	1.64687656
89	Colon cancer (HP:0003003)	1.64079733
90	Medial flaring of the eyebrow (HP:0010747)	1.63844063
91	External ear malformation (HP:0008572)	1.62546241
92	Elevated erythrocyte sedimentation rate (HP:0003565)	1.61584191
93	Decreased central vision (HP:0007663)	1.61104165
94	Hypoplastic iliac wings (HP:0002866)	1.60379866
95	Sclerocornea (HP:0000647)	1.59943456
96	Prenatal maternal abnormality (HP:0002686)	1.56673818
97	Abolished electroretinogram (ERG) (HP:0000550)	1.56374163
98	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.54704015
99	Purpura (HP:0000979)	1.54239206
100	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.53138979

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MKNK1	6.43736208
2	TAOK1	4.66361105
3	TAOK2	4.65309060
4	MAP3K11	3.67419960
5	MAP3K3	3.24076783
6	MAP2K3	2.88430550
7	JAK3	2.24840502
8	MKNK2	10.7816859
9	ABL2	1.79386083
10	DYRK1A	1.65496253
11	SRPK1	1.51263888
12	ZAK	1.47477542
13	VRK2	1.34754364
14	MAP3K5	1.17102879
15	BCKDK	1.16583066
16	TLK1	1.14730533
17	BUB1	1.12728559
18	VRK1	1.09066657
19	TXK	0.92284663
20	CHEK2	0.89821442
21	WNK3	0.87851334
22	MAP4K2	0.85934955
23	TRIM28	0.83345643
24	WNK4	0.83022130
25	KDR	0.80531598
26	TIE1	0.79453516
27	GRK1	0.78487802
28	PRKCQ	0.74355659
29	NUAK1	0.71069262
30	ADRBK2	0.65581124
31	DYRK2	0.60176922
32	MAP3K8	0.51684151
33	CCNB1	0.50721268
34	NEK1	0.46605297
35	STK16	0.46424859
36	MAP3K1	0.45830995
37	CDC7	0.45207610
38	PLK3	0.42602426
39	PINK1	0.42548952
40	TESK2	0.41828523
41	AURKA	0.39912554
42	EPHA4	0.39795289
43	STK39	0.38979312
44	INSRR	0.38017129
45	MST4	0.36996688
46	TSSK6	0.36604610
47	PLK4	0.36331072
48	FRK	0.35965840
49	EPHB2	0.35660254
50	CSNK1G3	0.35616940
51	DAPK3	0.35297043
52	CSNK1A1	0.32133073
53	OXSR1	0.31578631
54	CSNK1G2	0.31117969
55	EIF2AK1	0.29935693
56	PDK2	0.29697412
57	TAF1	0.29455814
58	CSNK2A2	0.26655090
59	OBSCN	0.26493613
60	PIK3CA	0.26328905
61	CSNK1G1	0.24842172
62	WEE1	0.24832818
63	CSNK2A1	0.24041788
64	PHKG2	0.23757580
65	PHKG1	0.23757580
66	RPS6KA5	0.23372905
67	CSNK1A1L	0.22125352
68	MAPK13	0.22071249
69	PRKCG	0.21992350
70	CDK19	0.20800071
71	EIF2AK3	0.20646442
72	PLK2	0.20197781
73	DAPK1	0.20128065
74	IGF1R	0.18935763
75	MAP2K6	0.18647706
76	PRKCD	0.18396384
77	LIMK1	0.18318983
78	GRK5	0.15581859
79	MAP2K7	0.15128815
80	PLK1	0.14296550
81	PRKACA	0.13800893
82	AURKB	0.13551067
83	CSNK1E	0.13229552
84	PRKCA	0.13064428
85	TEC	0.12613625
86	ITK	0.12469338
87	PASK	0.12126580
88	ATR	0.11912667
89	PKN1	0.11148277
90	BMPR1B	0.10812586
91	ABL1	0.10734921
92	SMG1	0.09529756
93	CAMK2A	0.08523261
94	PRKCE	0.07963577
95	MAP3K12	0.07534123
96	PBK	0.07523976
97	MINK1	0.07207939
98	PRKCB	0.06374226
99	MYLK	0.05678862
100	SYK	0.05336132

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	4.44882350
2	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	4.28711485
3	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	3.86751603
4	RNA polymerase_Homo sapiens_hsa03020	3.10049723
5	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.03172981
6	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.90684759
7	Oxidative phosphorylation_Homo sapiens_hsa00190	2.71434975
8	Parkinsons disease_Homo sapiens_hsa05012	2.32842300
9	Fatty acid elongation_Homo sapiens_hsa00062	2.25104019
10	Butanoate metabolism_Homo sapiens_hsa00650	2.18224440
11	Ribosome_Homo sapiens_hsa03010	2.14425460
12	One carbon pool by folate_Homo sapiens_hsa00670	2.05975252
13	Propanoate metabolism_Homo sapiens_hsa00640	2.04512246
14	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.97773747
15	Huntingtons disease_Homo sapiens_hsa05016	1.76379729
16	Tryptophan metabolism_Homo sapiens_hsa00380	1.60533079
17	Taste transduction_Homo sapiens_hsa04742	1.57065602
18	Primary immunodeficiency_Homo sapiens_hsa05340	1.52820204
19	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.49188712
20	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.43624974
21	Alzheimers disease_Homo sapiens_hsa05010	1.43571584
22	Peroxisome_Homo sapiens_hsa04146	1.41071231
23	Cardiac muscle contraction_Homo sapiens_hsa04260	1.35877693
24	beta-Alanine metabolism_Homo sapiens_hsa00410	1.35739362
25	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.30813246
26	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.29743015
27	Nucleotide excision repair_Homo sapiens_hsa03420	1.25618894
28	Caffeine metabolism_Homo sapiens_hsa00232	1.22969500
29	Pyrimidine metabolism_Homo sapiens_hsa00240	1.22559861
30	DNA replication_Homo sapiens_hsa03030	1.21295096
31	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.20261243
32	Glycerolipid metabolism_Homo sapiens_hsa00561	1.18546359
33	Fatty acid degradation_Homo sapiens_hsa00071	1.17033063
34	Protein export_Homo sapiens_hsa03060	1.14751163
35	Homologous recombination_Homo sapiens_hsa03440	1.11259674
36	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.08979363
37	Phototransduction_Homo sapiens_hsa04744	1.08691875
38	RNA transport_Homo sapiens_hsa03013	1.08134014
39	Fatty acid metabolism_Homo sapiens_hsa01212	1.06304307
40	Mismatch repair_Homo sapiens_hsa03430	1.03824788
41	Sulfur relay system_Homo sapiens_hsa04122	1.01860902
42	Nitrogen metabolism_Homo sapiens_hsa00910	0.97461202
43	Asthma_Homo sapiens_hsa05310	0.93508794
44	Lysine degradation_Homo sapiens_hsa00310	0.90434869
45	Purine metabolism_Homo sapiens_hsa00230	0.86887822
46	Fanconi anemia pathway_Homo sapiens_hsa03460	0.84845590
47	Alcoholism_Homo sapiens_hsa05034	0.84729832
48	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.84345234
49	Steroid biosynthesis_Homo sapiens_hsa00100	0.83568510
50	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.83113861
51	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.80113936
52	RNA degradation_Homo sapiens_hsa03018	0.79750207
53	Linoleic acid metabolism_Homo sapiens_hsa00591	0.78309928
54	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.76130121
55	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.75843557
56	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.73557465
57	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.69933022
58	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.69141870
59	Folate biosynthesis_Homo sapiens_hsa00790	0.66823753
60	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.66098405
61	Metabolic pathways_Homo sapiens_hsa01100	0.65269795
62	Graft-versus-host disease_Homo sapiens_hsa05332	0.63591553
63	Type I diabetes mellitus_Homo sapiens_hsa04940	0.62698549
64	Retinol metabolism_Homo sapiens_hsa00830	0.62575621
65	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.61789185
66	Chemical carcinogenesis_Homo sapiens_hsa05204	0.61645009
67	Fat digestion and absorption_Homo sapiens_hsa04975	0.59272893
68	Allograft rejection_Homo sapiens_hsa05330	0.59216395
69	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.58093725
70	Sulfur metabolism_Homo sapiens_hsa00920	0.57428053
71	Nicotine addiction_Homo sapiens_hsa05033	0.55408956
72	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.54792098
73	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.54577071
74	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.54429711
75	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.50840667
76	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.50070383
77	Antigen processing and presentation_Homo sapiens_hsa04612	0.50035861
78	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.50031527
79	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.49975906
80	Carbon metabolism_Homo sapiens_hsa01200	0.49645427
81	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.49366421
82	Olfactory transduction_Homo sapiens_hsa04740	0.45744419
83	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.44537260
84	Rheumatoid arthritis_Homo sapiens_hsa05323	0.43131738
85	Basal transcription factors_Homo sapiens_hsa03022	0.41378561
86	Viral myocarditis_Homo sapiens_hsa05416	0.40713895
87	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.38527577
88	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.38304350
89	Base excision repair_Homo sapiens_hsa03410	0.38018456
90	Glutathione metabolism_Homo sapiens_hsa00480	0.36653007
91	Non-homologous end-joining_Homo sapiens_hsa03450	0.34954303
92	Spliceosome_Homo sapiens_hsa03040	0.32423940
93	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.30048505
94	Pyruvate metabolism_Homo sapiens_hsa00620	0.26621598
95	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.24031901
96	Salmonella infection_Homo sapiens_hsa05132	0.23591624
97	Ether lipid metabolism_Homo sapiens_hsa00565	0.22757369
98	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.22742100
99	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.22516921
100	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.22467204

GAPDHP73

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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